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Existing literature from high-resource settings suggests that exposure to traumatic life events is associated with increased risk for psychosis. Research on how people with psychosis in South Africa perceive and make sense of their past traumatic life events is lacking. This study aimed to understand the lived experiences of persons living with psychosis in KwaZulu-Natal (KZN), South Africa. The study explored how individuals living with psychosis describe and conceptualize their traumatic life experiences and how it impacted them. We used a qualitative narrative research study design. Individual in-depth interviews were conducted in English and/or isiZulu with 19 adult patients with early psychosis who were receiving treatment at provincial hospitals in the eThekwini district in KZN, South Africa (mean age = 28.7±7.6, mostly male (68%) and unemployed (74%)). We analysed transcribed data using interpretive phenomenological analysis. Participants’ descriptions of traumatic life experiences included parent-child relationship disruption during their formative years and other adverse events associated with being separated from their parental figures including residential instability, financial hardship, sexual and physical abuse, and peer and community violence. Participants also described the experience of psychosis as a traumatic event. These traumatic experiences led to sense of loss for some participants, while others described post-traumatic stress symptoms including reexperiencing their trauma memories through psychotic episodes. The study provides clinical insight on the experiences of trauma among people with psychosis and highlights the need for adopting a trauma-informed service model in early psychosis care in South Africa.

By examining the sedimentary records from two new cores collected from the Sabrina Coast slope, we have developed an age model spanning from the late Pliocene to the present. From multiproxy sediment analyses of the piston and kasten core, PC03, and KC03, collected during the IN2017_V01 survey on the Sabrina Coast (East Antarctica) offshore the Totten Glacier, we here present the outcomes derived within the seismostratigraphic record coupled with the sedimentological, geochemical paleomagnetic, and biostratigraphic contexts. Our results highlight that the area has been affected by recurrent sediment slides facilitated by siliceous deposits, both biogenic and from an unprecedented tephra layer, during some of the major paleoclimatological events of the late Pliocene. Diatoms contributed not only to the biostratigraphic and depositional environmental definition but also to the instability of the slope, together with the tephra layer, as documented offshore the Sabrina–Aurora Basin for the first time.

Abstract The intrusion of relatively warm water onto the continental shelf is widely recognized as a threat to Antarctic ice shelves and glaciers grounded below sea level, as enhanced ocean heat increases their basal melt. While the circulation of warm water has been documented on the East Antarctic continental shelf, the modes of warm water transport from the deep ocean onto the shelf are still uncertain. This makes predicting the future responses of major East Antarctic marine-grounded glaciers, such as Totten and Ninnis glaciers, particularly challenging. Here, we outline the key role of submarine canyons to convey southward flowing currents that transport warm Circumpolar Deep Water toward the East Antarctic shelf break, thus facilitating warm water intrusion on the continental shelf. Sediment drifts on the eastern flank of the canyons provide evidence for sustained southward-directed flows. These morpho-sedimentary features thus highlight areas potentially prone to enhanced ocean heat transport toward the continental shelf, with repercussions for past, present, and future glacial melting and consequent sea level rise.

The effects of climate change have been studied and publicized by experts, civil society movements and organizations, international organizations, and felt in different ways around the world. To combat climate change, an energy transition to renewable sources is necessary, in addition to other policies and measures, including combating deforestation and forest degradation. In the Amazon, the energy transition has driven the expansion of hydroelectricity, in some cases, such as in Brazil, the region being considered the new energy frontier. However, the energy transition cannot ignore social inequalities and environmental impacts, it needs to be just, leaving no one behind. And this challenge of a just transition that faces the Amazon region, a provider of hydroelectric energy, but with a large part of its population without access to energy, or with access to energy from thermoelectric plants. This article seeks to discuss the challenges of a just energy transition in the Amazon, taking into account the difficulty of accessing energy in the region and the expansion of hydroelectricity, with its socio-environmental impacts.

This article aims to bring a discussion about inclusion in times of biopolitics and neoliberalism and, for that, we will present concepts and understandings about normalization, medicalization, and neoliberalism. In the search for an analytical movement and using the methodology of bibliographic research, we selected three academic works defended by the GEduMaD research group and we read them from the theoretical lens presented at the beginning of the text.

One of the metals used for bone implants is 316L Stainless Steel, which is succesfully coated with hydroxyapatite to increase its low biocompatibility. Therefore, this study aims to carry out sonication, alkali, and heating treatment on 316L Stainless Steel substrates, determine the effect of temperature (A) sonication time (B), acetone concentration (C), bidirectional interaction of sonication temperature and time (AB), bidirectional interaction of sonication time and acetone concentration (BC), bidirectional interaction of sonication temperature and acetone concentration (AC) and the three-way interaction of sonication temperature, time and acetone concentration (ABC), a suitable empirical model for the coating process, and concentration of cleaning solution on the bond strength of the hydroxyapatite layer. The empirical model of the bond strength of the hydroxyapatite layer used was y = 426.1 – 11.50A – 19.25B – 6.229C + 0.6505AB + 0.1944AC + 0.2737 BCE – 0.00933 ABC with an R2 value of 99.49%. The result showed that the layer's bond strength increases with the sonication temperature. It also showed that the longer the sonication time and the acetone concentration, the lower the bond strength value. The highest hydroxyapatite bond strength was produced at a sonication temperature, time, acetone concentration volume and bond strength of 45 °C, 15 min, 99%, and 91.35 Mpa, respectively.

The effects of high-pressure processing (HPP) (450 MPa/600 MPa/3 min) on the carotenoid and vitamin E contents of smoothies made from strawberry, orange juice, banana and apple, and the same smoothies enriched with dietary fiber from discarded carrots were compared. The contents and bioaccessibilities of these compounds were also evaluated over the course of 28 days at 4 °C. The application of HPP in the formulations significantly increased the contents of β-cryptoxanthin, α-carotene and β-carotene and retained the contents of lutein, zeaxanthin and vitamin E compared to untreated samples. A decreasing trend in the content of each compound was observed with an increase in storage time. The application of HPP initially led to reductions in the bioaccessibility of individual compounds. However, overall, during storage, there was an increase in bioaccessibility. This suggests that HPP influences cell structure, favoring compound release and micelle formation. HPP is a sustainable method that preserves or enhances carotenoid extractability in ready-to-drink fruit beverages. Furthermore, the incorporation of dietary fiber from carrot processing discards supports circular economy practices and enhances the health potential of the product.

O zoólogo suíço o Jean Louis Rodolphe Agassiz (1807-1873) criticou duramente a proposta de Charles Darwin logo após a publicação do Origin of species (1859). O objetivo deste artigo é discutir sobre a visão de Agassiz em relação às espécies no período compreendido entre 1857 e 1874, procurando detectar se houve mudanças. Esta pesquisa levou à conclusão de que no período considerado, Agassiz manteve sua posição fixista e criacionista e fez as mesmas críticas à proposta de Darwin. Estas diziam respeito principalmente à seleção natural, concepção de espécie e falta de evidências do gradualismo. Assim, não houve mudanças em sua posição.

Abstract We investigated the spatial relationships among 18 known seismogenic faults and 1651 wells drilled for gas exploitation in the main hydrocarbon province of northern-central Italy, a unique dataset worldwide. We adopted a GIS approach and a robust statistical technique, and found a significant anticorrelation between the location of productive wells and of the considered seismogenic faults, which are often overlain or encircled by unproductive wells. Our observations suggest that (a) earthquake ruptures encompassing much of the upper crust may cause gas to be lost to the atmosphere over geological time, and that (b) reservoirs underlain by smaller or aseismic faults are more likely to be intact. These findings, which are of inherently global relevance, have crucial implications for future hydrocarbon exploitation, for assessing the seismic–aseismic behaviour of large reverse faults, and for the public acceptance of underground energy and CO2 storage facilities—a pillar of future low carbon energy systems—in tectonically active areas.

Current glacier melt rates in West Antarctica substantially exceed those around the East Antarctic margin. The exception is Wilkes Land, where for example Totten Glacier underwent significant retreat between 2000 and 2012, underlining its sensitivity to climate change. This process is strongly influenced by ocean dynamics, which in turn changes in accordance with the evolution of the ice caps. Here, we present new oceanographic data (temperature, salinity, and dissolved oxygen) collected during austral summer 2017 offshore the Sabrina Coast (East Antarctica) from the continental shelf break to ca 3000 m depth. This area is characterized by very few oceanographic in situ observations. The main water masses of the study area, identified by analysing thermohaline properties, are the Antarctic Surface Water with potential temperature θ>-1.5 ∘C and salinity S (σθ kg m−3), the Winter Water with -1.92<θ<-1.75 ∘C and 34.00 ∘C and S>34.5 (σθ>27.7 kg m−3), and Antarctic Bottom Water with -0.50<θ<0 ∘C and 34.6328.30 kg m−3). The latter is a mixture of dense waters from the Ross Sea and Adélie Land continental shelves. Such waters are influenced by the mixing processes they undergo as they move westward along the Antarctic margin, also interacting with the warmer Circumpolar Deep Water. The spatial distribution of water masses offshore the Sabrina Coast also appears to be strongly linked with the complex morpho-bathymetry of the slope and rise area, supporting the hypothesis that downslope processes contribute to shaping the architecture of the distal portion of the continental margin. Oceanographic data presented here can be downloaded from https://doi.org/10.25919/yyex-t381 (CSIRO; Van Graas, 2021).

Uma aula e seis estudantes de um curso de Licenciatura em Matemática e um professor e um mestrando e um desafio (discutir Ética) e … O desafio foi lançado pelos estudantes, trazendo com ele outro: como fazê-lo? Escolhemos o (des)caminho da literatura. Para tal, inventamos três situações fictícias e convidamos os estudantes a fazerem um exercício de pensamento considerando a Ética enquanto campo da Filosofia. Durante as discussões, alguns temas atravessaram a discussão: punição, avaliação, relações familiares, amizade, aborto, legalidade e ilegalidade, classe, gênero, raça, moral, dentre outros. A partir da gravação e transcrição da aula, que foi realizada virtualmente, escrevemos um conto. Inspirados nos estudantes, lançamos um desafio a você que está lendo este artigo: como tens mobilizado a Ética em sua vida?

Premature birth is unpredictable and can result from social, economic and/or health-related factors for women and newborns. This study aimed to analyze the sociodemographic profile of parents of premature newborns admitted to a Neonatal Intensive Care Unit (NICU). Furthermore, it is a descriptive, exploratory, and quantitative study, carried out from March to August 2019 in an NICU. Demographic, socioeconomic, and data related to the newborn and the pregnancy process were collected with a questionnaire containing closed and open questions, which were analyzed and compared with related studies. 31 mothers and 19 fathers participated. Most of them were young and completed high school. Almost all fathers had paying jobs, while only half of mothers worked, and not all of them contributed to social security (INSS). Fathers received 30% more than mothers, even with similar functions and working hours. 47% of the families lived with an income of up to 2 minimum wages per month. Half of the pregnancies were unplanned. Births with gestational ages (GA) ≥ 32 weeks predominated. On average, the mothers had more than 8 prenatal consultations and displayed hypertension as the most prevalent maternal risk factor. Knowing the families of newborns can support measures to promote maternal and child health.

Dendritic cells (DC) play a major role during the priming phase of anti-tumor immunization, as they are required for an efficient tumor-associated antigens presentation. At least one dendritic cell-based therapy has already been successfully approved by regulators for clinical application in prostate cancer patients. Moreover, DC development is dependent on the granulocyte macrophage colony stimulating factor (GM-CSF), a cytokine that has been successfully used as a potent inducer of anti-tumoral immunity. To better understand the relation between DC and GM-CSF in anti-tumor immunity, we studied the DC function in mice lacking the cytokine receptor common subunit beta (βc-/-) for GM-CSF, IL-3 and IL-5 and immunized with irradiated tumor cells. Such immunization induces a protective, specific tumor immunization in wild-type mice, while βc-/- mice failed to mount an immune response. Upon in vitro stimulation, DC from βc-/- mice (DCβc-/-) are unable to undergo a full maturation level. In vivo experiments show that they lack the ability to prevent tumor growth, in contrast to DCWT. Moreover, matured DCWT rescued immunization in βc-/- mice. DC maturation is dependent on a functional pathway involving GM-CSF signaling through a biologically functional receptor. These findings may contribute to new strategies for efficient anti-tumor immunotherapies.

Lago Argentino hosts a series of calving glaciers originating from the Southern Patagonian Icefield, the largest temperate ice cap of the southern hemisphere. Brazo Rico and Brazo Sur are two basins located in the southern part of Lago Argentino, where a series of high-resolution seismic profiles have allowed reconstruction of its depositional setting and sedimentary architecture, and to produce the following maps: top of the acoustic basement, top of the glacial sequence, and thickness of the glacio-lacustrine deposits. Data reveal the role of basement highs in the complex dynamic behavior of the two main glaciers, Perito Moreno and Frías glaciers, which fluctuated along Brazo Rico and Brazo Sur since the end of the Last Glacial Maximum. Their advances and retreats are testified by the presence of several moraine fronts buried beneath a generally undisturbed, glacio-lacustrine and lacustrine sequence, which records the depositional history of the southern arms of Lago Argentino.

Este texto reúne onze dispositivos oficiais voltados à promoção da inclusão no Ensino Superior no Brasil. De posse dos textos, focaliza-se as prerrogativas conferidas aos universitários surdos a fim de evidenciar as possibilidades, os limites e as contradições existentes quanto à garantia do atendimento à diferença linguística deste público em todo o processo educacional que compreende a formação em nível superior. Para tanto, é estabelecida a relação dialógica entre os enunciados dos textos investigados e conclui-se que rejeitar a subordinação da Libras à Língua Portuguesa é um ato político de repúdio às práticas educacionais excludentes dirigidas aos universitários surdos. Afinal, ao supor que todos devam aprender na mesma língua, as propostas educacionais não deixam de estar ancoradas em uma construção profundamente universalista da identidade humana, que por assentarem-se na ideia de constituição inalterável do ser, define seus contornos excluindo os estudantes não-ouvintes.

Therapy by adoptive transfer of ex vivo-expanded tumor-infiltrating or genetically modified T cells may lead to impressive clinical responses. However, there is a need to improve in vivo persistence and functionality of the transferred T cells, in particular, to face the highly immunosuppressive environment of solid tumors. Here, we investigate the potential of miR-155, a microRNA known to play an important role in CD8+ T cell fitness. We show that forced expression of miR-155 in tumor antigen-specific T cells improves the tumor control of B16 tumors expressing a low-affinity antigen ligand. Importantly, miR-155-transduced T cells exhibit increased proliferation and effector functions associated with a higher glycolytic activity independent of exogenous glucose. Altogether, these data suggest that miR-155 may optimize the antitumor activity of adoptively transferred low-affinity tumor-infiltrating lymphocytes (TILs), in particular, by rendering them more resistant to the glucose-deprived environment of solid tumors. Thus, transgenic expression of miR-155 may enable therapeutic targeting of self-antigen-specific T cells in addition to neoantigen-specific ones. Keywords: microRNA-155, CD8+ T cells, TCR antigen affinity, therapeutic vaccine, adoptive cell transfer, oncoimmunology

Abstract In the last decades, geological degassing in shallow marine environments has been recognized as a significant contributor to atmospheric methane, hence to the global‐warming potential. Especially in shallow water environments, a proper assessment of the distribution, quantification and migration pathways of methane within the sediments is fundamental to help forecasting the amount that could leak and eventually reach the atmosphere. Traditionally, velocity anomalies from seismic data are the ones used to assess the occurrence of gas and its concentration. However, in shallow‐waters (

Resenha do livro de Maria Cecília Fantinato, Adriano Vargas Freitas. Etnomatemática: concepções, dinâmicas e desafios. Jundiaí: Editora Paco Editorial, 2018.

O presente artigo objetiva traçar o panorama da equipe de profissionais responsáveis pelo ensino em Libras e da Libras para a consecução da educação bilíngue atenta aos direitos linguísticos dos surdos, no Brasil. De caráter documental, o estudo envolveu a coleta dos Planos Nacional, Estaduais e Distrital de Educação, disponíveis no portal “PNE em Movimento”. Na sequência, os documentos foram lidos na íntegra, de modo a selecionar excertos que caracterizassem o perfil dos profissionais responsáveis pelo atendimento educacional dos estudantes surdos e exibi-los em mapas respeitando a ocorrência e distribuição por estados. Assim, foi possível comparar as escolhas efetuadas nos contextos locais, explicitar tendências e exceções e ativar a interlocução com os enunciados contidos nos Planos de Educação investigados e demais dispositivos oficiais a eles associados. Por intermédio das análises, múltiplas composições do quadro funcional foram identificadas e diferentes denominações apontaram atributos profissionais que denotam concepções distintas de educação bilíngue, as quais conferem valor diferenciado à Libras e, por conseguinte, aos estudantes surdos, no processo educacional. Em ordem decrescente, os Planos investigados indicam a provisão de intérpretes de Libras, professores do Atendimento Educacional Especializado, professores bilíngues e professores e/ou instrutores de Libras, prioritariamente surdos, para atender às demandas de escolarização dos estudantes surdos. Tais constatações permitiram problematizar propostas que concebem a Libras como recurso para o ensino em português, e evidenciar disposições que têm a língua de sinais como língua constitutiva das pessoas surdas que integram o sistema de ensino brasileiro.

Keluarga Berencana (KB) adalah salah satu program kebijakan pemerintah Indonesia yang berupaya untuk meningkatkan kesehatan reproduksi masyarakat sekaligus menurunkan laju pertumbuhan penduduk. Penelitian ini bertujuan untuk mengetahui pengaruh antara perempuan yang memiliki anak lahir hidup (X) terhadap keputusannya menggunakan alat/cara KB(Y) di Kabupaten Bogor dan Kota Bogor. Pendekatan rancangan dalam penelitian ini adalah kasus kontrol (case-control study) yang merupakan bagian dari penelitian observasional. Data yang digunakan berasal dari hasil survei yang dilakukan oleh Badan Pusat Statistik yaitu Survei Penduduk Antar Sensus (SUPAS) Tahun 2015. Hasil uji McNemar dengan koreksi kontinuitas menyatakan bahwa ada pengaruh yang nyata peubah X terhadap peubah Y yang dipadankan berdasarkan tingkat pendidikannya dan juga status kepemilikan bangunan tempat tinggal. Perhitungan rasio odds (RO) diperoleh nilai 31.71. Hal ini berarti kecenderungan perempuan berumur 10-54 tahun berstatus kawin yang memiliki anak untuk menggunakan KB adalah sebesar 31.71 kali dibandingkan dengan yang tidak atau belum memiliki anak lahir hidup.

We present a high-resolution swath bathymetric and backscatter map of the entire sector of the Marine Reserve Area (MRA) of the Asinara Island, along with a geological and sediment thickness map derived from the interpretation of a large set of high-resolution seismic profiles, and an airborne-derived hyperspectral image of the Asinara Island. Acquired data show that most of the eastern marine sector of the Asinara Island is characterized by quite gentle bathymetric gradients, whereas the western coastline appears to be very indented, with an articulated and rough morphology of the seafloor, which deepens sharply towards the open sea. The maps presented in this study at the 1:50.000 scale do not only provide the first, high-resolution bathymetry of the MRA of the Asinara Island but also may furnish the base for the creation of a benthic habitat map and a more comprehensive maritime spatial planning of this protected area.

Kondisi pembangunan manusia di suatu wilayah dapat digambarkan dengan perhitungan Indeks Pembangunan Manusia (IPM). Komponen yang membentuk IPM cenderung memiliki korelasi yang kuat antara satu dan yang lain, kondisi ini sering disebut multikolinieritas. Penelitian ini bertujuan untuk mengatasi masalah multikolinieritas dalam data IPM Provinsi DKI Jakarta pada periode 2010-2016. Penerapan metode PLS dalam penelitian ini mampu mengatasi masalah multikolinieritas dan membuat asumsi Gauss Markov dalam regresi linier berganda terpenuhi. Kata Kunci. Asumsi Gauss Markov, IPM, Multikolinearitas, PLS

ABSTRACT Objective: To identify and characterize music projects in the health area, their therapeutic goals, theoretical frameworks, evaluation/monitoring, and dissemination of their results for a possible structure model for this process. Method: Descriptive study with multiple cases and documental analysis. Results: Nine projects have participated in this study; these were predominantly in São Paulo and conducted with the adult population in public institutions. The coordinators were mostly women, specialists, with a qualification in health, music, or both. The interventions were performed live, with a mean of 60 minutes per week and repertoires selected by patients. Less than half indicated basing their activities in some theoretical framework or any type of project monitoring. Therapeutic goals related to social insertion and restoring self-esteem, citizenship, protagonism, and communication were pointed out. Conclusion: The theoretical indication of the music projects was scarce. Around half the analyzed projects indicated some type of evaluation and dissemination of the performed activities. Two projects only had some risk surveillance and scientific production out of their results, which has not enabled proposing a monitoring model for these initiatives.

The integrated analysis using different seismic wave types in a record is a very efficient approach for a comprehensive characterization of marine sediments, especially in shallow water conditions. The proposed integrated method to analyze seismic data in post-critical conditions consists of: 1) the inversion of Scholte waves to obtain a reliable Vs distribution of the near seafloor; 2) pre-processing of seismic data; 3) construction of the P-wave velocity field by using all available information, including available well data; and 4) the application of the wave equation datuming and post-processing, such as pre-stack time migration. We demonstrate how this approach could be successfully applied on seismic datasets characterized by post-critical conditions and the occurrence of the Scholte waves, which may be exploited to provide fundamental information instead of being only an unwanted effect. The integrated analysis of seismic events can thus help, together with data processing, by providing better seismic imaging, which is a priority for a reliable seismostratigraphic interpretation.

Este artigo objetiva vislumbrar linhas de fugas, intuir resistências e possibilidades outras para as aulas de Matemática. Para tal articulação, partiremos da noção de Educação Maior relacionando-a a Matemática Escolar e em contraposição, deslocando os conceitos de literatura menor de Gilles Deleuze e Félix Guattari e de educação menor de Sílvio Gallo, discutiremos o conceito de educação matemática menor. Por fim, na última seção, apresentaremos uma possibilidade de prática em educação matemática menor. Destacamos que a educação matemática menor potencializa resistências aos mecanismos de controle social e a Matemática Escolar.

PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are reduced to a group of patients. The research in combined therapies, which allow for a greater response, is strongly encouraging. We previously characterized a polyphenol-rich extract from Caesalpinia spinosa (P2Et) with antitumor activity in both melanoma and breast carcinoma, as well as immunomodulatory activity. We hypothesize that the combined treatment with P2Et and anti-PD-L1 can improve the antitumor response through an additive antitumor effect. We investigated the antitumor and immunomodulatory activity of P2Et and anti-PD-L1 combined therapy in B16-F10 melanoma and 4T1 breast carcinoma. We analyzed tumor growth, hematologic parameters, T cell counts, cytokine expression, and T cell cytotoxicity. In the melanoma model, combined P2Et and anti-PD-L1 therapy has the following effects: decrease in tumor size; increase in the number of activated CD4+ and CD8+ T cells; decrease in the number of suppressor myeloid cells; increase in PD-L1 expression; decrease in the frequency of CD8+ T cell expressing PD-1; improvement in the cytotoxic activity of T cells; and increase in the IFNγ secretion. In the breast cancer model, P2Et and PD-L1 alone or in combination show antitumor effect with no clear additive effect. This study shows that combined therapy of P2Et and anti-PD-L1 can improve antitumor response in a melanoma model by activating the immune response and neutralizing immunosuppressive mechanisms.

O presente artigo visa trazer algumas compreensões a respeito da Educação no Campo no contexto da Educação Inclusiva e da Educação Matemática. Nessa perspectiva, o texto começa com uma introdução ao conceito de Educação Inclusiva com um olhar para as singularidades e um desprendimento às categorizações, além de fazer uma relação entre a inclusão, em seu sentido mais amplo, e a Educação no Campo. Em um segundo momento, apresenta-se ideias centrais sobre Educação no Campo e apresentamos duas pesquisas que estão sendo realizadas no Programa de Pós-Graduação em Educação Matemática da Universidade Federal de Mato Grosso do Sul. Como considerações, há um convite à reflexão com a apresentação de excertos de narrativas, aproximações e intersecções entre a Educação Inclusiva e a Educação Matemática.

Resumo De caráter ensaístico, este texto contempla o diálogo entre os estudos surdos com viés pós-estruturalista e a filosofia da linguagem para abordar a diferença como não coincidência. Nele, a experiência da surdez é tratada como um evento singular, problematizando o aprisionamento dos corpos dos surdos às representações fixas, em nome de um projeto homogeneizador marcado pela reprodução da identidade. Ninguém se afirma, pois a força universalista da padronização linguística é diretamente proporcional a invisibilidade daqueles que ouvem e oralizam. Entretanto, afirmar-se evidencia a insubmissão dos surdos ao projeto monolíngue e monocultural ouvinte e denuncia a tentativa de fixação da identidade ditada pelos cânones da normalidade. As relações opositivas que marcam a identidade surda e a normalidade ouvinte trazem consigo a impossibilidade do diálogo, mantendo invisíveis os clamores das mãos que sinalizam nos territórios habitados por vozes inacessíveis aos ouvidos dos surdos, na contramão da alteridade.

Abstract Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that CART cells progressively upregulate Fas, FasL, DR5 and TRAIL, which result in their programmed cell death, independently of antigen-mediated TCR or CAR activation. CART cell apoptosis occurs even when the CAR contains a single (co-)activatory domain such as CD3ζ, CD28 or 4-1BB. Importantly, the dominant role of the Fas and DR5 pathways in CART cell apoptosis is demonstrated by the significant rescue of CART cells upon in vivo blockade by combined Fas-Fc and DR5-Fc recombinant proteins. These observations are of crucial importance for the long-term persistence of CART cells and for the development of new applications including the combined TCR and CAR activation against solid tumors.

The development of inclusive policies and the commitment to universalize the basic education leaded to interventions guided to the expansion of the Higher Education. Thus, students with disabilities have started to plead vacancies in the Higher Education. Under those circumstances, we propose to investigate the rules which guide the entrance examinations in three Brazilian public uni- versities, in order to identity the explanations given to the disabled candidates concerning registration, test applying and correction. According to a theoreti- cal-documental approach, processing and analysis of the collected materials were inferred from the contributions of the theoretical approach to the sense production, proposed by Spink. Results showed restrictions in offering specia- lized attendance to candidates with disabilities, as well as a lack of compliance to the educational recommendations and rules in force.