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BackgroundSurvivors of Islamic State of Iraq and Syria (ISIS) captivity are at high risk of developing mental disorders such as post-traumatic stress disorder (PTSD).AimsThis study looks at the correlation between sexual abuse, shame, somatoform or bodily distress disorders, and dissociative seizures (psychogenic non-epileptic seizures).MethodThe psychological effects of traumatic events and dissociative seizure were assessed in Yazidi women who were held captive by ISIS in Northern Iraq between 2014 and 2018. These effects were examined comparing 64 women who were held captive and sexually abused by ISIS with 60 women suffering from PTSD who were not held captive and sexually abused by ISIS. Structured clinical-psychological interviews and established psychometric questionnaires were used to assess mental disorders especially dissociative seizures and somatoform disorders, and shame related to trauma.ResultsWomen who were held captive by ISIS showed a significantly higher prevalence of dissociative seizures (43.7%; P = 0.02) and somatisation disorder (38.7%; P = 0.02), as well as depressive (75.0%; P = 0.42) and anxiety disorders (62.5%; P = 0.44), than women who were not held captive and sexually abused by ISIS. Dissociative disorders were identified in 40.6% (P = 0.36) of those female Yazidi who experienced sexual violence while being held captive.ConclusionsShame in connection with sexual violence seems to play an important role in negative self-perception after rape. Dissociation not only plays an important role in unprocessed childhood trauma with feelings of shame, but also in more recent trauma experiences with shame.

Background: Thus far, most researchers on genocide and transgenerational transmissions have focused on the National Socialist Holocaust as the most abhorrent example of this severe human rights violation. Few data have been published on other ethnic or religious groups affected by genocidal actions in this context. Methodology: Using a mixed-method approach integrating qualitative interviews with standardized instruments (SCID and PDS), this study examines how individual and collective trauma have been handed down across three generations in an Alevi Kurd community whose members (have) suffered genocidal perpetrations over a longer time period (a “genocidal environment”). Qualitative, open-ended interviews with members of three generations answering questions yielded information on (a) how their lives are shaped by the genocidal experiences from the previous generation and related victim experiences, (b) how the genocidal events were communicated in family narratives, and (c) coping strategies used. The first generation is the generation which directly suffered the genocidal actions. The second generation consists of children of those parents who survived the genocidal actions. Together with their family (children, partner, relatives), this generation suffered forced displacement. Members of the third generation were born in the diaspora where they also grew up. Results: Participants reported traumatic memories, presented in examples in this publication. The most severe traumatic memories included the Dersim massacre in 1937–1938 in Turkey, with 70,000–80,000 victims killed, and the enforced resettlement in western Turkey. A content analysis revealed that the transgenerational transmission of trauma continued across three generations. SCID and PDS data indicated high rates of distress in all generations. Conclusions: Genocidal environments such as that of the Kurdish Alevis lead to transgenerational transmission mediated by complex factors.

International audience; Experiencing pleasure and displeasure is a fundamental part of life. Hedonics guide behavior, affect decision-making, induce learning, and much more. As the positive and negative valence of feelings, hedonics are core processes that accompany emotion, motivation, and bodily states. Here, the affective neuroscience of pleasure and displeasure that has largely focused on the investigation of reward and pain processing, is reviewed. We describe the neurobiological systems of hedonics and factors that modulate hedonic experiences (e.g., cognition, learning, sensory input). Further, we review maladaptive and adaptive pleasure and displeasure functions in mental disorders and well-being, as well as the experience of aesthetics. As a centerpiece of the Human Affectome Project, language used to express pleasure and displeasure was also analyzed, and showed that most of these analyzed words overlap with expressions of emotions, actions, and bodily states. Our review shows that hedonics are typically investigated as processes that accompany other functions, but the mechanisms of hedonics (as core processes) have not been fully elucidated.

Following the severe attacks by the so-called “Islamic State of Iraq and Syria” on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities and towns in Baden-Württemberg to receive integrated care. Here, we report for the first time on the cases of four Yazidi women living in Ulm, Germany, focusing on the clinically observed and psychometrically assessed mental phenomena or disorders. Our primary aim was to explore what International Classification of Diseases, 10th Revision diagnoses are present in this population. Although highly traumatized, these women were suffering primarily from adjustment disorder rather than posttraumatic stress disorder according to official classification systems. Despite their symptoms of depression and anxiety, the women’s responses to self-assessment questionnaires provided no evidence of compulsion, somatization, or eating disorders. The results suggest that further investigation of the individual-level effects of rape and torture, as well the historic, systemic, and collective effects, e.g., on families and societies, is required.

In recent years, Islamic terrorism has manifested itself with an unexpectedly destructive force. Despite the fact that Islamic terrorism commences locally in most cases, it has spread its terror worldwide. In August 2014, when troops of the self-proclaimed ‘Islamic State’ conquered areas of northern Iraq, they turned on the long-established religious minorities in the area with tremendous brutality, especially towards the Yazidis. Vast numbers of men were executed, and women and children were abducted and willfully subjected to sexual violence. With the aim of systematic destruction of the Yazidi community, the religious minority was to be eliminated and the will of the victims broken. The medical and mental health issues arising from the combination of subjective, collective, and cultural traumatization, as well as the subsequent migrant and refugee crisis, are therefore extraordinary and require novel and wise concepts of integrated medical care.

The ICD-10 offers the possibility of double coding of diagnoses in functional disorders on the one hand, somatoform disorders on the other side. The current S3 guideline for "dealing with patients with non-specific, functional and somatoform physical complaints" states that "[...] in most cases, the specialty of the (initial) examiner and not the clinical constellation seems to define how a diagnosis is made". Based on selective routine data of the Daimler BKK for the years 2008-2010 frequencies of specific functional diagnoses were compared with those of somatoform disorders, additional diagnoses analyzed and compared with epidemiological data from the Federal Health Monitoring System. The incidence found in epidemiological studies of somatoform disorders cannot be found in present routine data. Functional disorders were more frequently diagnosed than somatoform disorders. Certain additional diagnoses that may provide clues to etiological relations are rarely used. As the validity, reliability and purpose of ICD-10 invoicing diagnoses is debatable, there seems to be an imbalance relevant for the health care system. Non-adherence to the guidelines may prevent adequate quality and quantity of patient care.

Background: In many Western countries, after a motor vehicle collision, those involved seek health care for the assessment of injuries and for insurance documentation purposes. In contrast, in many less wealthy countries, there may be limited access to care and no insurance or compensation system. Objective: The purpose of this infodemiology study was to investigate the global pattern of evolving Internet usage in countries with and without insurance and the corresponding compensation systems for whiplash injury. Methods: We used the Internet search engine analytics via Google Trends to study the health information-seeking behavior concerning whiplash injury at national population levels in Europe. Results: We found that the search for “whiplash” is strikingly and consistently often associated with the search for “compensation” in countries or cultures with a tort system. Frequent or traumatic painful injuries; diseases or disorders such as arthritis, headache, radius, and hip fracture; depressive disorders; and fibromyalgia were not associated similarly with searches on “compensation.” Conclusions: In this study, we present evidence from the evolving viewpoint of naturalistic Internet search engine analytics that the expectations for receiving compensation may influence Internet search behavior in relation to whiplash injury. [JMIR Public Health Surveill 2017;3(1):e15]

Background: Without stimulation, the human brain spontaneously produces highly organized, low-frequency fluctuations of neural activity in intrinsic connectivity networks (ICNs). Furthermore, without adequate explanatory nociceptive input, patients with somatoform pain disorder experience pain symptoms, thus implicating a central dysregulation of pain homeostasis. The present study aimed to test whether interactions among pain-related ICNs, such as the default mode network (DMN), cingular‐insular network (CIN) and sensorimotor network (SMN), are altered in somatoform pain during resting conditions. Methods: Patients with somatoform pain disorder and healthy controls underwent resting functional magnetic resonance imaging that lasted 370 seconds. Using a data-driven approach, the ICNs were isolated, and the functional network connectivity (FNC) was computed. Results: Twenty-one patients and 19 controls enrolled in the study. Significant FNC (p < 0.05, corrected for false discovery rate) was detected between the CIN and SMN/anterior DMN, the anterior DMN and posterior DMN/SMN, and the posterior DMN and SMN. Interestingly, no group differences in FNC were detected. Limitations: The most important limitation of this study was the relatively short resting state paradigm. Conclusion: To our knowledge, our results demonstrated for the first time the resting FNC among pain-related ICNs. However, our results suggest that FNC signatures alone are not able to characterize the putative central dysfunction underpinning somatoform pain disorder.

Functional disorders in urology are troubling for both patients and physicians. Moreover, advances in recent research promise to provide biological insights into psycho-neuro-endocrino-immunological pathways that are one important facet of chronic urogenital inflammations. We present a case of a middle-aged woman with long-lasting recurrent cystitis for which especially a psychosomatic approach helped to understand and cure the disorder. Altogether, as practitioners treat subjects, not illnesses, a biopsychosocial understanding of human disease should be taken into account in cases of chronic recurrent cystitis.

The ICD-10 offers the possibility of double coding of diagnoses in functional disorders on the one hand, somatoform disorders on the other side. The current S3 guideline for "dealing with patients with non-specific, functional and somatoform physical complaints" states that "[...] in most cases, the specialty of the (initial) examiner and not the clinical constellation seems to define how a diagnosis is made". Based on selective routine data of the Daimler BKK for the years 2008-2010 frequencies of specific functional diagnoses were compared with those of somatoform disorders, additional diagnoses analyzed and compared with epidemiological data from the Federal Health Monitoring System. The incidence found in epidemiological studies of somatoform disorders cannot be found in present routine data. Functional disorders were more frequently diagnosed than somatoform disorders. Certain additional diagnoses that may provide clues to etiological relations are rarely used. As the validity, reliability and purpose of ICD-10 invoicing diagnoses is debatable, there seems to be an imbalance relevant for the health care system. Non-adherence to the guidelines may prevent adequate quality and quantity of patient care.

The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), are critically important for growth, survival and activity-dependent synaptic strengthening in the central nervous system. These TrkB-mediated actions occur in a highly cell-type specific manner. Here we report that cerebellar Purkinje cells, which are richly endowed with TrkB receptors, develop a normal morphology in trkB-deficient mice. Thus, in contrast to other types of neurons, Purkinje cells do not need TrkB for dendritic growth and spine formation. Instead, we find a moderate delay in the maturation of GABAergic synapses and, more importantly, an abnormal multiple climbing fiber innervation in Purkinje cells in trkB-deficient mice. Thus, our results demonstrate an involvement of TrkB receptors in synapse elimination and reveal a new role for receptor tyrosine kinases in the brain.

Background: Successful social interaction relies on the ability to attribute mental states to other people. Previous functional neuroimaging studies have shown that this process, described as Theory of Mind (ToM) or mentalization, is reliably associated with activation of the medial prefrontal cortex (mPFC). However, this study presents a novel and surprising finding that provides new insight into the role of the mPFC in mentalization tasks. Methodology/Principal Findings: Twenty healthy individuals were recruited from a wide range of ages and social backgrounds. Participants underwent functional magnetic resonance imaging (fMRI) while viewing a well-established ToM visual paradigm involving moving triangles. Functional MRI data were analyzed using a classical general linear model. No activation was detected in the medial prefrontal cortex (mPFC) during movement patterns that typically elicit ToM. However, increased activity was observed in the right middle occipital gyrus, right temporoparietal junction (TPJ), left middle occipital gyrus and right inferior frontal gyrus. No correlation was found between participants’ age and BOLD response. Conclusions/Significance: In contrast with previous neuroimaging research, our findings support the notion that mPFC function is not critical for reasoning about the mental states of others; furthermore, our data indicate that the right TPJ and right inferior frontal gyrus are able to perform mentalization without any contributions from the mPFC.

Conversion disorder is a medical condition in which a person has paralysis, blindness, or other neurological symptoms that cannot be clearly explained physiologically. To date, there is neither specific nor conclusive treatment. In this paper, we draw together a number of disparate pieces of knowledge to propose a novel intervention to provide transient alleviation for this condition. As caloric vestibular stimulation (CVS) has been demonstrated to modulate transiently a variety of cognitive functions associated with brain activations, especially in the temporal-parietal cortex, anterior cingulate cortex, and insular cortex, there is evidence to assume an effect in specific mental disorders. Therefore, we go on to hypothesize that lateralized cold vestibular caloric stimulation will be effective in treating conversion disorder and we present provisional evidence from one patient that supports this conclusion. If our hypothesis is correct, this will be the first time in psychiatry and neurology that a clinically well-known mental disorder, long considered difficult to understand and to treat, is relieved by a simple or common, non-invasive medical procedure.

In 1998, Eric Kandel wrote in his intriguing paper titled “A new intellectual framework for psychiatry” (Kandel, 1998) that “the unique domain which psychiatry occupies within academic medicine, the analysis of the interaction between social and biological determinants of behavior, can best be studied by also having a full understanding of the biological components of behavior.” Fifteen years later, much like surfers who continue a frustrated and longing pursuit for the next “big one” (Cowan et al., 2000; Kandel, 2006), we are, according to Henrik Walter, in the midst of the third wave of biological psychiatry (Walter, 2013). Because a wave is, in a physical sense, a disturbance that propagates through space and time while transferring energy, there are at least three reoccurring “thermodynamic sinks” that I would like to also emphasize with Walter to ultimately better understand the complexity of the human brain in action (Bassett, 2011). First is the rediscovery of the coequal contributions of emotions and affects toward normal brain functioning (Damasio, 2003; Tsuchiya and Adolphs, 2007). After Michael Gazzaniga and George Miller “invented” “cognitive neuroscience” in the late 1980s (Zorumski and Rubin, 2011), the predominance of a cognition-centered view of “higher” (and perhaps as one facet: more noble?) brain functions was able to again delay necessary and not so new “insults” to our species and misdirect (in its top-down-view of brain functioning) the conceptualization and treatment of mental disorders (Cromwell and Panksepp, 2011; Almada et al., 2013). Neurobiology helps us recalibrate the human wishful thinking we had come to appreciate regarding the “higher” and “lower” of the “conditio humana” imprinted in our (neuro)physiology. As the world divides into facts, there is in fact no such hierarchy imprinted in our brains. Rather, the brain seems to favor “dynamic coalitions of networks of brain areas with a high degree of connectivity,” and these networks - or the connectome - should not be conceptualized as being specifically affective or cognitive (Pessoa, 2008). Second is the rediscovery of the body in biological psychiatry. Walter mentions the “4Es” (embodiment, embeddedness, enactivism, extended cognition) and the challenge of so-called “situatedness” (Walter, 2013). However, the very first step toward valuing the operant inter-wovenness of mind and body might be a simpler one. Interestingly of ectodermal origin, neural tissue emerged enabling motor control in an evolutionary beneficial way. The brain originates in relation to a body that again, in relation to the outer world, actively moves – and, not least, gained the ability to interact with other bodies. Sensory information about the “situation,” the re-flective information involved in reflexes, is primarily able to close the loop and help coordinate movement. If Antonio R. Damasio is right, there is a need for emotions before we can feel anything, and these emotions are intimately connected with “more or less the complex reactions the body has to certain stimuli” (Damsio, 2005). These so-called “somatic markers” (Damasio, 1996) apparently make us capable of making predominantly beneficial decisions for self-preservation and the (we have to admit: biologically sexual) preservation of our species. It is designative that the brain is the “unmoved mover.” However, changes are also reflected in the brain itself if the “motor-sensory” connections to the body are disturbed, e.g., in paraplegia (Wiens, 2005; Lenggenhager et al., 2012). The fantasy of an ever-dreaming, monolithic (but nonetheless self-conscious) “brain in a vat” that could reasonably think (or meaningfully simulate) about “what is it like to be a bat” (Nagel, 1974) currently suffers from not only solipsistic but also neurobiological-Darwinistic (so to say “inborn”) pitfalls. In this manifold context, it is interesting that today's “modern or third wave” of psychiatry is more willing to pay increased attention to enigmatic somatic symptom disorders (other than at first glance mere “brain disorders” such as schizophrenia, depression, addiction, and dementia) and attempts to incorporate the body and its imprinted neural representation into a genuine, more holistic understanding of the field. One could interpret it as a new esteem of anciently quirky psychosomatics in biological psychiatry that overcomes its centro-centric monodimensionality. Third is the rediscovery of the importance of “being in relation” for reasonable neural functioning, especially in terms of social relationships for the human brain. From birth until death, human mammals need the “significant other(s),” and it is perhaps the most integrating framework covering cognitive and affective neurosciences that will give rise to emerging social neurosciences (Eisenberger and Cole, 2012; Singer, 2012). Newly emerging imaging techniques, such as hyperscanning (Babiloni and Astolfi, 2012), i.e., the simultaneous recording of brain activity of different subjects that allows “the study of inter-brain correlations between the cerebral activity of a group of interacting subjects as a unique system” (Babiloni and Astolfi, 2012), will help us understand the brain and perhaps pave the way to a central second-person neuroscience (Schilbach et al., 2013). Against this background, and only as one important example, empathy and the question of its quality and quantity in men have gained more and more attention in modern neuroscience (Gonzalez-Liencres et al., 2013). Psychotherapy and its proven impact on mental health (Etkin et al., 2005), before any technical question, fundamentally relies on the quality of the relation between two human beings (like patient and therapist) (Ardito and Rabellino, 2011). One could, again, interpret this rediscovery as the new esteem of anciently subordinate psychotherapy in biological psychiatry. Finally, after three waves, a fourth wave seems inevitable. I would venture to predict that this “new wave” will belong to the computational neurosciences (Wen et al., 2011; Poldrack et al., 2012) and arise from the background of information integration theory (Tononi, 2005). The Human Brain Project (Markram, 2012) which was awarded one of the European Union's Flagship grants in 2013, worth more than €1 billion ($1.35 billion) over the next ten years, aims for the first time to tie or link up all knowledge of and to simulate the complete human brain from the molecule to the cortex on supercomputers to better understand how it functions (or even malfunctions), is ultimately the first step into a new era of real cooperativeness among neuroscientists and brains (Markram, 2013). Unfortunately, largely without “third wave” psychiatry. Just as affect and cognition, body and soul, the body-bound brain and the brain of my conspecific, and psychiatry and psychosomatics grow together, entities that belong together grow together. We have the opportunity to see the emergence of a new, non-reductionist science of fractal brains, as we examine mental orders and disorders differently, in a “brainy way,” with more cooperation and integration than ever before. In one word, in accordance with Henry Markram (Kandel et al., 2013): exciting!

Corticotropin-releasing hormone (CRH) plays an important role in a substantial number of patients with stress-related mental disorders, such as anxiety disorders and depression. CRH has been shown to increase neuronal excitability in the hippocampus, but the underlying mechanisms are poorly understood. The effects of CRH on neuronal excitability were investigated in acute hippocampal brain slices. Population spikes (PS) and field excitatory postsynaptic potentials (fEPSP) were evoked by stimulating Schaffer-collaterals and recorded simultaneously from the somatic and dendritic region of CA1 pyramidal neurons. CRH was found to increase PS amplitudes (mean ± Standard error of the mean; 231.8 ± 31.2% of control; n = 10) while neither affecting fEPSPs (104.3 ± 4.2%; n = 10) nor long-term potentiation (LTP). However, when Schaffer-collaterals were excited via action potentials (APs) generated by stimulation of CA3 pyramidal neurons, CRH increased fEPSP amplitudes (119.8 ± 3.6%; n = 8) and the magnitude of LTP in the CA1 region. Experiments in slices from transgenic mice revealed that the effect on PS amplitude is mediated exclusively by CRH receptor 1 (CRHR1) expressed on glutamatergic neurons. The effects of CRH on PS were dependent on phosphatase-2B, L- and T-type calcium channels and voltage-gated potassium channels but independent on intracellular Ca(2+)-elevation. In patch-clamp experiments, CRH increased the frequency and decay times of APs and decreased currents through A-type and delayed-rectifier potassium channels. These results suggest that CRH does not affect synaptic transmission per se, but modulates voltage-gated ion currents important for the generation of APs and hence elevates by this route overall neuronal activity.

Three decades ago, such terms as computer art, virtual reality and computer animation had not yet entered our vocabulary. This was a time for the experimentation and innovation that produced today's industry of computer art and animation, along with new media for creative experiences with computers. The author has used digital computers in a variety of the visual arts, including still images, stereoscopic images, computer holography, three-dimensional animation, four-dimensional animation, interactive stereoscopic displays and input devices and, ultimately, three-dimensional force-feedback, the latter becoming a major component of today's virtual reality. This research and experimentation in computer art was performed during the 1960s, and in this article he reminisces and decribes his early work.

As a complementary medical procedure, acupuncture has a significant impact on the treatment of acute and chronic pain. Though the physiological mechanisms behind this method are still unclear, acupuncture has been claimed to rely also on changes in the central nervous system. Recent functional imaging studies indicate that the so-called default mode network (DMN) which consists of cortical midline structures and lateral parietal regions plays an important role in these processes. This brief overview describes the effects of analgesic acupuncture on the DMN architecture. The stronger interplay between systems dedicated to endogenous analgesia (periaqueductal gray), affective processing (anterior cingulate cortex, amygdala), memory (hippocampus), and self-projective thinking (DMN) following this therapy supports the notion that acupuncture is a mind-body therapy which helps to reintegrate important neural dimensions of inner life and to establish psychophysical pain homeostasis.

BackgroundMultisomatoform disorder is characterised by severe and disabling bodily symptoms, and pain is one of the most common and impairing of these. Furthermore, these bodily symptoms cannot be explained by an underlying organic disorder. Patients with multisomatoform disorder are commonly found at all levels of healthcare and are typically difficult to treat for physicians as well as for mental health specialists.AimsTo test whether brief psychodynamic interpersonal therapy (PIT) effectively improves the physical quality of life in patients who have had multisomatoform disorder for at least 2 years.MethodWe recruited 211 patients (from six German academic out-patient centres) who met the criteria for multisomatoform disorder for a randomised, controlled, 12-week, parallel-group trial from 1 July 2006 to 1 January 2009 (International Standard Randomised Controlled Trial Number ISRCTN23215121). We randomly assigned the patients to receive either 12 weekly sessions of PIT (n = 107) or three sessions of enhanced medical care (EMC, n = 104). The physical component summary of the Short Form Health Survey (SF-36) was the pre-specified primary outcome at a 9-month follow-up.ResultsPsychodynamic interpersonal therapy improved patients' physical quality of life at follow-up better than EMC (mean improvement in SF-36 score: PIT 5.3, EMC 2.2), with a small to medium between-group effect size (d = 0.42, 95% CI 0.15–0.69, P = 0.001). We also observed a significant improvement in somatisation but not in depression, health anxiety or healthcare utilisation.ConclusionsThis trial documents the long-term efficacy of brief PIT for improving the physical quality of life in patients with multiple, difficult-to-treat, medically unexplained symptoms.

Background: Asthma is a frequently disabling and almost invariably distressing disease that has a high overall prevalence. Although relaxation techniques and hypnotherapeutic interventions have proven their effectiveness in numerous trials, relaxation therapies are still not recommended in treatment guidelines due to a lack of methodological quality in many of the trials. Therefore, this study aims to investigate the efficacy of the brief relaxation technique of functional relaxation (FR) and guided imagery (GI) in adult asthmatics in a randomized controlled trial. Methods: 64 patients with extrinsic bronchial asthma were treated over a 4-week period and assessed at baseline, after treatment and after 4 months, for follow-up. 16 patients completed FR, 14 GI, 15 both FR and GI (FR/GI) and 13 received a placebo relaxation technique as the control intervention (CI). The forced expiratory volume in the first second (FEV1) as well as the specific airway resistance (sRaw) were employed as primary outcome measures. Results: Participation in FR, GI and FR/GI led to increases in FEV1 (% predicted) of 7.6 ± 13.2, 3.3 ± 9.8, and 8.3 ± 21.0, respectively, as compared to –1.8 ± 11.1 in the CI group at the end of the therapy. After follow-up, the increases in FEV1 were 6.9 ± 10.3 in the FR group, 4.4 ± 7.3 in the GI and 4.5 ± 8.1 in the FR/GI, compared to –2.8 ± 9.2 in the CI. Improvements in sRaw (% predicted) were in keeping with the changes in FEV1 in all groups. Conclusions: Our study confirms a positive effect of FR on respiratory parameters and suggests a clinically relevant long-term benefit from FR as a nonpharmacological and complementary therapy treatment option.

Long-term depression (LTD) of Purkinje cell–parallel fiber synaptic transmission is a critical determinant of normal cerebellar function. Impairment of LTD through, for example, disruption of the metabotropic glutamate receptor–IP(3)–calcium signaling cascade in mutant mice results in severe deficits of both synaptic transmission and cerebellar motor control. Here, we demonstrate that selective genetic deletion of the calcium-binding protein calbindin D-28k (calbindin) from cerebellar Purkinje cells results in distinctly different cellular and behavioral alterations. These mutants display marked permanent deficits of motor coordination and sensory processing. This occurs in the absence of alterations in a form of LTD implicated in the control of behavior. Analysis of synaptically evoked calcium transients in spines and dendrites of Purkinje cells demonstrated an alteration of time course and amplitude of fast calcium transients after parallel or climbing fiber stimulation. By contrast, the delayed metabotropic glutamate receptor-mediated calcium transients were normal. Our results reveal a unique role of Purkinje cell calbindin in a specific form of motor control and suggest that rapid calcium buffering may directly control behaviorally relevant neuronal signal integration.

Considerable excitement has been generated in Europe and North America in videotex - namely, the concept of electronic access in the home to centrally - located computerized databases containing vast amounts of data. However, the public offering of such services has thus far been unsuccessful in achieving significant penetrations in the residential market. Videotex is examined in this paper to illuminate possible reasons for its failure thus far in the residential marketplace. Comparisons are made with somewhat similar on-line systems for accessing computerized data-bases and for performing transactions and transmitting messages to other people. The final conclusion is that most consumers simply do not have a need nor a desire to access vast computerized data-bases of general information. Videotex or any other similar system that attempts to satisfy consumer needs for information in such a fashion will surely fail.

A spectrum analyzer based on a definition of short‐time power spectra has been designed and simulated on a digital computer. The analyzer is primarily intended for use in speech analysis. It has been designed to operate in real time, and to produce high‐resolution spectra without utilizing either heterodyning methods or bandpass filter banks. The logarithm of each consecutive amplitude spectrum thus obtained can be used as the input to a second similar spectrum analyzer. The output of this analyzer is then the “cepstrum” or power spectrum of the logarithm spectrum. The cepstrum of a speech signal has a peak corresponding to the fundamental period for voiced speech but no peak for unvoiced speech. Thus, a cepstrum analyzer can function both as a pitch and as a voiced‐unvoiced detector. Cepstral pitch detection has the important advantages that it is insensitive to phase distortion, and is also resistant to additive noise and amplitude distortion of the speech signal. The method does not require the presence of the fundamental frequency in the speech signal, and will give several separate cepstral peaks if several different pitch periods are present. Cepstral techniques appear to be even more reliable and efficient than visual methods for pitch detection. The short‐time spectrum and cepstrum analyzers described in this paper were simulated by a sampled‐data system on an IBM‐7090 digital computer. The simulation was programmed with the assistance of a special block‐diagram compiler.

A digital computer and automatic plotter have been used to generate three-dimensional stereoscopic movies of the three-dimensional parallel and perspective projections of four-dimensional hyperobjects rotating in four-dimensional space. The observed projections and their motions were a direct extension of three-dimensional experience, but no profound "feeling" or insight into the fourth spatial dimension was obtained. The technique can be generalized to n-dimensions and applied to any n-dimensional hyperobject or hypersurface.

The cepstrum, defined as the power spectrum of the logarithm of the power spectrum, has a strong peak corresponding to the pitch period of the voiced‐speech segment being analyzed. Cepstra were calculated on a digital computer and were automatically plotted on microfilm. Algorithms were developed heuristically for picking those peaks corresponding to voiced‐speech segments and the vocal pitch periods. This information was then used to derive the excitation for a computer‐simulated channel vocoder. The pitch quality of the vocoded speech was judged by experienced listeners in informal comparison tests to be indistinguishable from the original speech.

A television-like scanned-display system has been successfully implemented on a Honeywell DDP-224 computer installation. The scanned image is stored in the core memory of the computer, and software scan conversion is used to convert the rectangular coordinates of a point to the appropriate word and bit in an output display array in core storage. Results thus far indicate that flicker-free displays of large amounts of data are possible with reasonably fast graphical interaction. A scanned image of size 240 X 254 points is displayed at a 30 frame-per-second rate.

Digital computers are now being used to produce musical sounds and to generate artistic visual images. The artist or composer interacts directly with the computer through a console. This article explores the possibilities of the computer as an artistic medium and makes some predictions about the art of the future.

Research in automatic speech production, like research in automatic speech recognition, seems to be regressing at an ever‐increasing rate when compared with the over‐all progress of technology. Both speech production and speech recognition involve human beings and perceptual phenomena about which very little information is available. A negative attitude towards either automatic speech recognition or automatic speech production logically must lead to a negative attitude towards the other. Hence, speech research aimed at automating either the recognition or the production of speech will require many years of effort before anything approaching practical results is obtained. The speech process should ultimately be investigated for its own intrinsic merit—not for satisfying man‐machine communication needs.

Somatoforme Schmerzen sind ein sowohl in der Primärals auch der fachsomatischen Versorgung häufiges Beschwerdebild. Neben somatisch nicht ausreichend zu erklärenden Schmerzen aller Lokalisationen treten häufig auch umschriebene Funktionsstörungen einzelner Organsysteme wie Schwindel, Herz- oder Verdauungsbeschwerden sowie Erschöpfungsbeschwerden auf. Gleichzeitig klagen viele Patienten über depressive oder Angstsymptome. Während psychodynamisch-interaktionelle Modelle eine frühe Beeinträchtigung der Körperbeziehung sowie eine ungenügende Affektdifferenzierung in den Vordergrund stellen, fokussieren kognitiv-behaviorale Modelle somatosensorische Amplifikationsprozesse. Die organische Ursachenüberzeugung der Patienten sowie die im Durchschnitt lange Anamnesedauer mit Enttäuschungen über die zahlreichen, meist unbefriedigenden Behandlungsversuchen bedingen nicht selten interaktionelle Schwierigkeiten in der Arzt-Patienten- Beziehung. Schulenübergreifende Handlungsempfehlungen betonen eine aktive Haltung des Therapeuten, Legitimation der Schmerzbeschwerden sowie Hilfe bei der Symptombewältigung. Psychodynamische Ansätze fokussieren zudem Affektdifferenzierung sowie die Bearbeitung von im Zusammenhang mit Schmerzerleben berichteten Beziehungsepisoden., Patients with severe and disabling pain and bodily distress which cannot be explained by underlying organic pathology are common in all levels of health care and are typically difficult to treat for physicians as well as for mental health specialists. Beside pain in different locations, not fully explained by specific somatic pathology, specific functional complaints such as dizziness, fatigue or vegetative disorders are common. A great proportion of patients with somatoform pain complain of comorbid depressive or anxiety disorder. Psychodynamic-interpersonal psychotherapy particularly emphasises interpersonal processes as well as disturbance of body awareness and self regulation already in childhood. Cognitive-behavioral models focus on the phenomenon of somatosensory amplification. The patients do have a strong believe in an underlying somatic illness, therefore seeking for further diagnostic and somatic therapy. This frequently leads to multiple but ineffective therapeutic attempts in the field of somatic medicine resulting in frustration of the patients and a difficult doctor-patient-relationship. General therapeutic recommendations include an active therapeutic approach with paying tribute for the patients’ suffering and giving support to cope with the pain. A specific psychodynamic approach furthermore focuses on improvement of affect differentiation and the interaction of somatoform pain and interpersonal relationships.

Background Recent functional imaging studies on chronic pain of various organic etiologies have shown significant alterations in both the spatial and the temporal dimensions of the functional connectivity of the human brain in its resting state. However, it remains unclear whether similar changes in intrinsic connectivity networks (ICNs) also occur in patients with chronic pain disorder, defined as persistent, medically unexplained pain. Methods We compared 21 patients who suffered from chronic pain disorder with 19 age- and gender-matched controls using 3T-fMRI. All neuroimaging data were analyzed using both independent component analysis (ICA) and power spectra analysis. Results In patients suffering from chronic pain disorder, the fronto-insular ‘salience’ network (FIN) and the anterior default mode network (aDMN) predominantly oscillated at higher frequencies (0.20 - 0.24 Hz), whereas no significant differences were observed in the posterior DMN (pDMN) and the sensorimotor network (SMN). Conclusions Our results indicate that chronic pain disorder may be a self-sustaining and endogenous mental process that affects temporal organization in terms of a frequency shift in the rhythmical dynamics of cortical networks associated with emotional homeostasis and introspection.