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1. Mortality and risk factors of vaccinated and unvaccinated frail patients with COVID-19 treated with anti-SARS-CoV-2 monoclonal antibodies: A real-world study

Author

Nevola, Riccardo, Feola, Giovanni, Ruocco, Rachele, Russo, Antonio, Villani, Angela, Fusco, Raffaele, De Pascalis, Stefania, Core, Micol Del, Cirigliano, Giovanna, Pisaturo, Mariantonietta, Loffredo, Giuseppe, Rinaldi, Luca, Marrone, Aldo, Starace, Mario, Sposito, Pellegrino De Lucia, Cozzolino, Domenico, Salvatore, Teresa, Lettieri, Miriam, Marfella, Raffaele, Sasso, Ferdinando Carlo, Coppola, Nicola, and Adinolfi, Luigi Elio

Published
2023
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2. The number of risk factors not at target is associated with cardiovascular risk in a type 2 diabetic population with albuminuria in primary cardiovascular prevention. Post-hoc analysis of the NID-2 trial

Author

Sasso, Ferdinando Carlo, Simeon, Vittorio, Galiero, Raffaele, Caturano, Alfredo, De Nicola, Luca, Chiodini, Paolo, Rinaldi, Luca, Salvatore, Teresa, Lettieri, Miriam, Nevola, Riccardo, Sardu, Celestino, Docimo, Giovanni, Loffredo, Giuseppe, Marfella, Raffaele, Adinolfi, Luigi Elio, and Minutolo, Roberto

Published
2022
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4. Non-invasive respiratory support in SARS-CoV-2 related acute respiratory distress syndrome: when is it most appropriate to start treatment?

Author

Nevola, Riccardo, Russo, Antonio, Scuotto, Samuel, Imbriani, Simona, Aprea, Concetta, Abitabile, Marianna, Beccia, Domenico, Brin, Chiara, Carusone, Caterina, Cinone, Francesca, Cirigliano, Giovanna, Colantuoni, Sara, Cozzolino, Domenico, Cuomo, Giovanna, Del Core, Micol, Gjeloshi, Klodian, Marrone, Aldo, Medicamento, Giulia, Meo, Luciana Agnese, Nappo, Francesco, Padula, Andrea, Pafundi, Pia Clara, Ranieri, Roberta, Ricozzi, Carmen, Rinaldi, Luca, Romano, Ciro Pasquale, Ruocco, Rachele, Ruosi, Carolina, Salvati, Annabella, Sasso, Ferdinando Carlo, Sellitto, Ausilia, Sommese, Pino, Villani, Angela, Coppola, Nicola, and Adinolfi, Luigi Elio

Published
2022
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6. Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study

Author

Caturano, Alfredo, primary, Galiero, Raffaele, additional, Vetrano, Erica, additional, Medicamento, Giulia, additional, Alfano, Maria, additional, Beccia, Domenico, additional, Brin, Chiara, additional, Colantuoni, Sara, additional, Di Salvo, Jessica, additional, Epifani, Raffaella, additional, Nevola, Riccardo, additional, Marfella, Raffaele, additional, Sardu, Celestino, additional, Coppola, Carmine, additional, Scarano, Ferdinando, additional, Maggi, Paolo, additional, Calabrese, Cecilia, additional, De Lucia Sposito, Pellegrino, additional, Rescigno, Carolina, additional, Sbreglia, Costanza, additional, Fraganza, Fiorentino, additional, Parrella, Roberto, additional, Romano, Annamaria, additional, Calabria, Giosuele, additional, Polverino, Benedetto, additional, Pagano, Antonio, additional, Numis, Fabio Giuliano, additional, Bologna, Carolina, additional, Nunziata, Mariagrazia, additional, Esposito, Vincenzo, additional, Coppola, Nicola, additional, Maturo, Nicola, additional, Nasti, Rodolfo, additional, Di Micco, Pierpaolo, additional, Perrella, Alessandro, additional, Adinolfi, Luigi Elio, additional, Di Domenico, Marina, additional, Monda, Marcellino, additional, Russo, Vincenzo, additional, Ruggiero, Roberto, additional, Docimo, Giovanni, additional, Rinaldi, Luca, additional, and Sasso, Ferdinando Carlo, additional

Published
2024
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7. Impact of chronic liver disease on SARS-CoV-2 infection outcomes: Roles of stage, etiology and vaccination

Author

Nevola, Riccardo, Criscuolo, Livio, Beccia, Domenico, Delle Femine, Augusto, Ruocco, Rachele, Imbriani, Simona, Alfano, Maria, Villani, Angela, Russo, Antonio, Perillo, Pasquale, Marfella, Raffaele, Adinolfi, Luigi Elio, Sasso, Ferdinando Carlo, Marrone, Aldo, Rinaldi, Luca, Nevola, Riccardo, Criscuolo, Livio, Beccia, Domenico, Delle Femine, Augusto, Ruocco, Rachele, Imbriani, Simona, Alfano, Maria, Villani, Angela, Russo, Antonio, Perillo, Pasquale, Marfella, Raffaele, Adinolfi, Luigi Elio, Sasso, Ferdinando Carlo, Marrone, Aldo, and Rinaldi, Luca

Subjects
Cirrhosi, SARS-CoV-2 infection, Chronic liver disease, Gastroenterology, COVID-19, General Medicine, Liver injury, Non-alcoholic fatty liver disease
Abstract

Since the first identification in December of 2019 and the fast spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, it has represented a dramatic global public health concern. Though affecting mainly the respiratory system, SARS-CoV-2 disease, defined as coronavirus disease 2019 (COVID-19), may have a systemic involvement leading to multiple organ dysfunction. Experimental evidence about the SARS-CoV-2 tropism for the liver and the increasing of hepatic cytolysis enzymes during infection support the presence of a pathophysiological relationship between liver and SARS-CoV-2. On the other side, patients with chronic liver disease have been demonstrated to have a poor prognosis with COVID-19. In particular, patients with liver cirrhosis appear extremely vulnerable to infection. Moreover, the etiology of liver disease and the vaccination status could affect the COVID-19 outcomes. This review analyzes the impact of the disease stage and the related causes on morbidity and mortality, clinical outcomes during SARS-CoV-2 infection, as well as the efficacy of vaccination in patients with chronic liver disease.

Published
2023
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8. Liver Involvement during SARS-CoV-2 Infection Is Associated with a Worse Respiratory Outcome in COVID-19 Patients

Author

Romano, Ciro, primary, Cozzolino, Domenico, additional, Nevola, Riccardo, additional, Abitabile, Marianna, additional, Carusone, Caterina, additional, Cinone, Francesca, additional, Cuomo, Giovanna, additional, Nappo, Francesco, additional, Sellitto, Ausilia, additional, Umano, Giuseppina Rosaria, additional, Adinolfi, Luigi Elio, additional, Marrone, Aldo, additional, and Rinaldi, Luca, additional

Published
2023
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9. Long-Term Prognosis among COVID-19 Patients: The Predictive Role Played by Hyperinflammation and Arrhythmic Disorders in Fatal Outcome

Author

Cozzolino, Domenico, primary, Romano, Ciro, additional, Sardu, Celestino, additional, Nevola, Riccardo, additional, Umano, Giuseppina Rosaria, additional, Rinaldi, Luca, additional, Adinolfi, Luigi Elio, additional, Catalini, Christian, additional, Marrone, Aldo, additional, Municinò, Maurizio, additional, Sasso, Ferdinando Carlo, additional, and Marfella, Raffaele, additional

Published
2023
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10. Incidence and risk factors of early HCC occurrence in HCV patients treated with direct acting antivirals: a prospective multicentre study

Author

Rinaldi, Luca, Perrella, Alessandro, Guarino, Maria, De Luca, Massimo, Piai, Guido, Coppola, Nicola, Pafundi, Pia Clara, Ciardiello, Fortunato, Fasano, Morena, Martinelli, Erika, Valente, Giovanna, Nevola, Riccardo, Monari, Caterina, Miglioresi, Lucia, Guerrera, Barbara, Berretta, Massimiliano, Sasso, Ferdinando Carlo, Morisco, Filomena, Izzi, Antonio, and Adinolfi, Luigi Elio

Published
2019
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11. Sodium-Glucose Co-Transporters Family: Current Evidence, Clinical Applications and Perspectives

Author

Nevola, Riccardo, primary, Villani, Angela, primary, Imbriani, Simona, primary, Alfano, Maria, primary, Criscuolo, Livio, primary, Beccia, Domenico, primary, Ruocco, Rachele, primary, Femine, Augusto Delle, primary, Gragnano, Felice, primary, Cozzolino, Domenico, primary, Marfella, Raffaele, primary, Adinolfi, Luigi Elio, primary, Sasso, Ferdinando Carlo, primary, and Rinaldi, Luca, primary

Published
2023
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12. HBV Infection and Host Interactions: The Role in Viral Persistence and Oncogenesis

Author

Nevola, Riccardo, primary, Beccia, Domenico, additional, Rosato, Valerio, additional, Ruocco, Rachele, additional, Mastrocinque, Davide, additional, Villani, Angela, additional, Perillo, Pasquale, additional, Imbriani, Simona, additional, Delle Femine, Augusto, additional, Criscuolo, Livio, additional, Alfano, Maria, additional, La Montagna, Marco, additional, Russo, Antonio, additional, Marfella, Raffaele, additional, Cozzolino, Domenico, additional, Sasso, Ferdinando Carlo, additional, Rinaldi, Luca, additional, Marrone, Aldo, additional, Adinolfi, Luigi Elio, additional, and Claar, Ernesto, additional

Published
2023
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13. Predictors of early and late hepatocellular carcinoma recurrence

Author

Nevola, Riccardo, primary, Ruocco, Rachele, additional, Criscuolo, Livio, additional, Villani, Angela, additional, Alfano, Maria, additional, Beccia, Domenico, additional, Imbriani, Simona, additional, Claar, Ernesto, additional, Cozzolino, Domenico, additional, Sasso, Ferdinando Carlo, additional, Marrone, Aldo, additional, Adinolfi, Luigi Elio, additional, and Rinaldi, Luca, additional

Published
2023
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16. Association between Renal Function at Admission and COVID-19 in-Hospital Mortality in Southern Italy: Findings from the Prospective Multicenter Italian COVOCA Study

Author

Galiero, Raffaele, Simeon, Vittorio, Loffredo, Giuseppe, Caturano, Alfredo, Rinaldi, Luca, Vetrano, Erica, Medicamento, Giulia, Alfano, Maria, Beccia, Domenico, Brin, Chiara, Colantuoni, Sara, Di Salvo, Jessica, Epifani, Raffaella, Nevola, Riccardo, Marfella, Raffaele, Sardu, Celestino, Coppola, Carmine, Scarano, Ferdinando, Maggi, Paolo, Calabrese, Cecilia, De Lucia Sposito, Pellegrino, Rescigno, Carolina, Sbreglia, Costanza, Fraganza, Fiorentino, Parrella, Roberto, Romano, Annamaria, Calabria, Giosuele, Polverino, Benedetto, Pagano, Antonio, Numis, Fabio Giuliano, Bologna, Carolina, Nunziata, Mariagrazia, Esposito, Vincenzo, Coppola, Nicola, Maturo, Nicola, Nasti, Rodolfo, Di Micco, Pierpaolo, Perrella, Alessandro, Lettieri, Miriam, Adinolfi, Luigi Elio, Chiodini, Paolo, Sasso, Ferdinando Carlo, On Behalf Of Covoca Study Group, null, Galiero, Raffaele, Simeon, Vittorio, Loffredo, Giuseppe, Caturano, Alfredo, Rinaldi, Luca, Vetrano, Erica, Medicamento, Giulia, Alfano, Maria, Beccia, Domenico, Brin, Chiara, Colantuoni, Sara, Di Salvo, Jessica, Epifani, Raffaella, Nevola, Riccardo, Marfella, Raffaele, Sardu, Celestino, Coppola, Carmine, Scarano, Ferdinando, Maggi, Paolo, Calabrese, Cecilia, De Lucia Sposito, Pellegrino, Rescigno, Carolina, Sbreglia, Costanza, Fraganza, Fiorentino, Parrella, Roberto, Romano, Annamaria, Calabria, Giosuele, Polverino, Benedetto, Pagano, Antonio, Numis, Fabio Giuliano, Bologna, Carolina, Nunziata, Mariagrazia, Esposito, Vincenzo, Coppola, Nicola, Maturo, Nicola, Nasti, Rodolfo, Di Micco, Pierpaolo, Perrella, Alessandro, Lettieri, Miriam, Adinolfi, Luigi Elio, Chiodini, Paolo, Sasso, Ferdinando Carlo, and On Behalf Of Covoca Study Group, Null

Subjects
COVID-19, chronic kidney diseases, in-hospital mortality, General Medicine, chronic kidney disease
Abstract

Background. Evidence has shown a close association between COVID-19 infection and renal complications in both individuals with previously normal renal function and those with chronic kidney disease (CKD). Methods. The aim of this study is to evaluate the in-hospital mortality of SARS-CoV-2 patients according to their clinical history of CKD or estimated glomerular filtration rate (eGFR). This is a prospective multicenter observational cohort study which involved adult patients (≥18 years old) who tested positive with SARS-CoV-2 infection and completed their hospitalization in the period between November 2020 and June 2021. Results. 1246 patients were included in the study, with a mean age of 64 years (SD 14.6) and a median duration of hospitalization of 15 days (IQR 9–22 days). Cox’s multivariable regression model revealed that mortality risk was strongly associated with the stage of renal impairment and the Kaplan–Meier survival analysis showed a progressive and statistically significant difference (p < 0.0001) in mortality according to the stage of CKD. Conclusion. This study further validates the association between CKD stage at admission and mortality in patients hospitalized for COVID-19. The risk stratification based on eGFR allows clinicians to identify the subjects with the highest risk of intra-hospital mortality despite the duration of hospitalization.

Published
2022

19. Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department

Author

Giordano, Mauro, primary, Trotta, Maria Consiglia, additional, Ciarambino, Tiziana, additional, D’Amico, Michele, additional, Schettini, Federico, additional, Sisto, Angela Di, additional, D’Auria, Valentina, additional, Voza, Antonio, additional, Malatino, Lorenzo Salvatore, additional, Biolo, Gianni, additional, Mearelli, Filippo, additional, Franceschi, Francesco, additional, Paolisso, Giuseppe, additional, and Adinolfi, Luigi Elio, additional

Published
2022
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20. Prediction of SARS-CoV-2-Related Lung Inflammation Spreading by V:ERITAS (Vanvitelli Early Recognition of Inflamed Thoracic Areas Spreading)

Author

Romano, Ciro, primary, Cozzolino, Domenico, additional, Cuomo, Giovanna, additional, Abitabile, Marianna, additional, Carusone, Caterina, additional, Cinone, Francesca, additional, Nappo, Francesco, additional, Nevola, Riccardo, additional, Sellitto, Ausilia, additional, Auricchio, Annamaria, additional, Cardella, Francesca, additional, Del Sorbo, Giovanni, additional, Lieto, Eva, additional, Galizia, Gennaro, additional, Adinolfi, Luigi Elio, additional, Marrone, Aldo, additional, and Rinaldi, Luca, additional

Published
2022
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21. Epidemiology of HCV and HBV in a High Endemic Area of Southern Italy: Opportunities from the COVID-19 Pandemic—Standardized National Screening or One Tailored to Local Epidemiology?

Author

Nevola, Riccardo, primary, Messina, Vincenzo, additional, Marrone, Aldo, additional, Coppola, Nicola, additional, Rescigno, Carolina, additional, Esposito, Vincenzo, additional, Sangiovanni, Vincenzo, additional, Claar, Ernesto, additional, Pisaturo, Mariantonietta, additional, Fusco, Francesco Maria, additional, Rosario, Pietro, additional, Izzi, Antonio, additional, Pisapia, Raffaella, additional, Rosato, Valerio, additional, Maggi, Paolo, additional, and Adinolfi, Luigi Elio, additional

Published
2022
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23. Additional file 1 of The number of risk factors not at target is associated with cardiovascular risk in a type 2 diabetic population with albuminuria in primary cardiovascular prevention. Post-hoc analysis of the NID-2 trial

Author

Sasso, Ferdinando Carlo, Simeon, Vittorio, Galiero, Raffaele, Caturano, Alfredo, De Nicola, Luca, Chiodini, Paolo, Rinaldi, Luca, Salvatore, Teresa, Lettieri, Miriam, Nevola, Riccardo, Sardu, Celestino, Docimo, Giovanni, Loffredo, Giuseppe, Marfella, Raffaele, Adinolfi, Luigi Elio, and Minutolo, Roberto

Abstract

Additional file 1: Table S1. Test of Likelihood ratio for interaction term. Table S2. Test of proportional-hazards assumption. Table S3. Sensitivity analysis comparing patients with absent information for at least one of the variables included in the score (missing group) and those without missing data. Table S4. Risks for MACEs and all-cause mortality by risk group at univariate Cox model and after adjustment for confounding variables. Figure S1. Sensitivity analysis comparing survival estimates for MACE and overall survival (OS) in patients with absent information for at least one of the variables included in the score (missing group) and those without missing data.

Published
2022
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25. Efficacy and durability of multifactorial intervention on mortality and MACEs:a randomized clinical trial in type-2 diabetic kidney disease

Author

Sasso, F. C., Pafundi, Pia Clara, Simeon, Vittorio, De Nicola, L., Chiodini, Paolo, Galiero, Raffaele, Rinaldi, Luca, Nevola, Riccardo, Salvatore, Teresa, Sardu, Celestino, Marfella, Raffaele, Adinolfi, Luigi Elio, Minutolo, R., Amelia, U., Acierno, C., Calatola, P., Carbonara, O., Caturano, A., Conte, G., Corigliano, G., Corigliano, M., D’Urso, R., De Matteo, A., De Rosa, N., Del Vecchio, E., Di Giovanni, G., Gatti, A., Gentile, S., Gesuè, L., Improta, L., Lampitella, A., Lanzilli, A., Lascar, N., Masi, S., Mattei, P., Mastrilli, V., Memoli, P., Nasti, R., Pagano, A., Pentangelo, M., Pisa, E., Rossi, E., Sorrentino, S., Torella, R., Troise, R., Trucillo, P., and NID-2 Study Group Investigators

Abstract

Background: Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the risk of a poor outcome. DKD is associated with a very high cardiovascular risk, which requires simultaneous treatment of these risk factors by implementing an intensified multifactorial treatment approach. However, the efficacy of a multifactorial intervention on major fatal/non-fatal cardiovascular events (MACEs) in DKD patients has been poorly investigated. Methods: Nephropathy in Diabetes type 2 (NID-2) study is a multicentre, cluster-randomized, open-label clinical trial enrolling 395 DKD patients with albuminuria, diabetic retinopathy (DR) and negative history of CV events in 14 Italian diabetology clinics. Centres were randomly assigned to either Standard-of-Care (SoC) (n = 188) or multifactorial intensive therapy (MT, n = 207) of main cardiovascular risk factors (blood pressure < 130/80 mmHg, glycated haemoglobin < 7%, LDL, HDL and total cholesterol < 100 mg/dL, > 40/50 mg/dL for men/women and < 175 mg/dL, respectively). Primary endpoint was MACEs occurrence by end of follow-up phase. Secondary endpoints included single components of primary endpoint and all-cause death. Results: At the end of intervention period (median 3.84 and 3.40 years in MT and SoC group, respectively), targets achievement was significantly higher in MT. During 13.0 years (IQR 12.4–13.3) of follow-up, 262 MACEs were recorded (116 in MT vs. 146 in SoC). The adjusted Cox shared-frailty model demonstrated 53% lower risk of MACEs in MT arm (adjusted HR 0.47, 95%CI 0.30–0.74, P = 0.001). Similarly, all-cause death risk was 47% lower (adjusted HR 0.53, 95%CI 0.29–0.93, P = 0.027). Conclusion: MT induces a remarkable benefit on the risk of MACEs and mortality in high-risk DKD patients. Clinical Trial Registration ClinicalTrials.gov number, NCT00535925. https://clinicaltrials.gov/ct2/show/NCT00535925

Published
2021

27. Additional file 1 of Efficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease

Author

Sasso, Ferdinando Carlo, Pafundi, Pia Clara, Simeon, Vittorio, De Nicola, Luca, Chiodini, Paolo, Galiero, Raffaele, Rinaldi, Luca, Nevola, Riccardo, Salvatore, Teresa, Sardu, Celestino, Marfella, Raffaele, Adinolfi, Luigi Elio, and Minutolo, Roberto

Abstract

Additional file 1: Appendix S1. Intervention by randomization.

Published
2021
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29. Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly: A study of the Cancer of the Liver Italian Program (CLIP)

Author

Pignata, Sandro, Gallo, Ciro, Daniele, Bruno, Elba, Silvana, Giorgio, Antonio, Capuano, Gaetano, Adinolfi, Luigi Elio, De Sio, Ilario, Izzo, Francesco, Farinati, Fabio, Naja, Carlo Del, Stanzione, Maria, Castiglione, Fabiana, Marone, Giampiero, Cuomo, Oreste, Felder, Martina, Gaeta, Giovanni Battista, Maio, Ermelinda De, Maio, Massimo Di, Signoriello, Giuseppe, and Perrone, Francesco

Published
2006
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31. Sustained virological response in patients with HCV treated with daclatasvir plus sofosbuvir, with or without ribavirin: a large, field-practice study

Author

Sacco, Rodolfo, primary, Messina, Vincenzo, additional, Vespasiani Gentilucci, Umberto, additional, Adinolfi, Luigi Elio, additional, Ascione, Antonio, additional, Barbarini, Giorgio, additional, Barlattani, Angelo, additional, Cariti, Giuseppe, additional, Cozzolongo, Raffaele, additional, Fimiani, Basilio, additional, Francavilla, Ruggiero, additional, Furlan, Caterina, additional, Garrucciu, Giovanni, additional, Iovinella, Vincenzo, additional, Rinaldi, Luca, additional, Marignani, Massimo, additional, Begini, Paola, additional, Palitti, Valeria Pace, additional, Pellicelli, Adriano M, additional, Scifo, Gaetano, additional, Facciorusso, Antonio, additional, Giacomelli, Luca, additional, Shah, Aashni, additional, Bertino, Gaetano, additional, Perazzo, Serena, additional, Bresci, Giampaolo, additional, and Izzi, Antonio, additional

Published
2020
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32. Circulating MiRNA-195-5p and -451a in Diabetic Patients with Transient and Acute Ischemic Stroke in the Emergency Department

Author

Giordano, Mauro, primary, Trotta, Maria Consiglia, additional, Ciarambino, Tiziana, additional, D’Amico, Michele, additional, Galdiero, Marilena, additional, Schettini, Federico, additional, Paternosto, Diego, additional, Salzillo, Marta, additional, Alfano, Roberto, additional, Andreone, Vincenzo, additional, Malatino, Lorenzo Salvatore, additional, Biolo, Gianni, additional, Paolisso, Giuseppe, additional, and Adinolfi, Luigi Elio, additional

Published
2020
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34. Atypical Presentation of a Rare Parasitic Infection with Fasciola hepatica: A Multidisciplinary Case Report

Author

Rinaldi, Luca, primary, Folliero, Veronica, additional, Restivo, Luciano, additional, Foglia, Francesco, additional, Franci, Gianluigi, additional, Chianese, Annalisa, additional, Iuliano, Natalina, additional, De Luca, Serena, additional, Guerrera, Barbara, additional, Del Viscovo, Luca, additional, and Adinolfi, Luigi Elio, additional

Published
2020
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36. Risk of Hepatocellular Carcinoma after HCV Clearance by Direct-Acting Antivirals Treatment Predictive Factors and Role of Epigenetics

Author

Rinaldi, Luca, primary, Nevola, Riccardo, additional, Franci, Gianluigi, additional, Perrella, Alessandro, additional, Corvino, Giusy, additional, Marrone, Aldo, additional, Berretta, Massimiliano, additional, Morone, Maria Vittoria, additional, Galdiero, Marilena, additional, Giordano, Mauro, additional, Adinolfi, Luigi Elio, additional, and Sasso, Ferdinando Carlo, additional

Published
2020
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37. Tocilizumab in Paget's Disease of Bone and Rheumatoid Arthritis: A Case Report

Author

Adinolfi Luigi Elio, Frongillo Elisabetta Maria, Cuomo Giovanna, Romano Ciro, Scognamiglio Gaetano, Cuomo, Giovanna, Romano, Ciro Pasquale, Frongillo, Elisabetta Maria, Scognamiglio, Gaetano, and Adinolfi, Luigi Elio

Subjects
chemistry.chemical_compound, medicine.medical_specialty, Tocilizumab, Paget's disease of bone, chemistry, business.industry, Rheumatoid arthritis, medicine, medicine.disease, business, Dermatology
Published
2018

39. Efficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease.

Author

Sasso, Ferdinando Carlo, Pafundi, Pia Clara, Simeon, Vittorio, De Nicola, Luca, Chiodini, Paolo, Galiero, Raffaele, Rinaldi, Luca, Nevola, Riccardo, Salvatore, Teresa, Sardu, Celestino, Marfella, Raffaele, Adinolfi, Luigi Elio, Minutolo, Roberto, NID-2 Study Group Investigators, Amelia, U., Acierno, C., Calatola, P., Carbonara, O., Caturano, A., and Conte, G.

Subjects
DIABETIC nephropathies, CLINICAL trials, HDL cholesterol, TYPE 2 diabetes, DIABETIC retinopathy, MAJOR adverse cardiovascular events
Abstract

Background: Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the risk of a poor outcome. DKD is associated with a very high cardiovascular risk, which requires simultaneous treatment of these risk factors by implementing an intensified multifactorial treatment approach. However, the efficacy of a multifactorial intervention on major fatal/non-fatal cardiovascular events (MACEs) in DKD patients has been poorly investigated. Methods: Nephropathy in Diabetes type 2 (NID-2) study is a multicentre, cluster-randomized, open-label clinical trial enrolling 395 DKD patients with albuminuria, diabetic retinopathy (DR) and negative history of CV events in 14 Italian diabetology clinics. Centres were randomly assigned to either Standard-of-Care (SoC) (n = 188) or multifactorial intensive therapy (MT, n = 207) of main cardiovascular risk factors (blood pressure < 130/80 mmHg, glycated haemoglobin < 7%, LDL, HDL and total cholesterol < 100 mg/dL, > 40/50 mg/dL for men/women and < 175 mg/dL, respectively). Primary endpoint was MACEs occurrence by end of follow-up phase. Secondary endpoints included single components of primary endpoint and all-cause death. Results: At the end of intervention period (median 3.84 and 3.40 years in MT and SoC group, respectively), targets achievement was significantly higher in MT. During 13.0 years (IQR 12.4–13.3) of follow-up, 262 MACEs were recorded (116 in MT vs. 146 in SoC). The adjusted Cox shared-frailty model demonstrated 53% lower risk of MACEs in MT arm (adjusted HR 0.47, 95%CI 0.30–0.74, P = 0.001). Similarly, all-cause death risk was 47% lower (adjusted HR 0.53, 95%CI 0.29–0.93, P = 0.027). Conclusion: MT induces a remarkable benefit on the risk of MACEs and mortality in high-risk DKD patients. Clinical Trial Registration ClinicalTrials.gov number, NCT00535925. https://clinicaltrials.gov/ct2/show/NCT00535925 [ABSTRACT FROM AUTHOR]

Published
2021
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40. Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes

Author

Sasso, Ferdinando Carlo, Rinaldi, Luca, Lascar, Nadia, Marrone, Aldo, Pafundi, Pia Clara, Adinolfi, Luigi Elio, and Marfella, Raffaele

Subjects
Article Subject
Abstract

Both incidence and mortality of acute coronary syndrome (ACS) among diabetic patients are much higher than those among nondiabetics. Actually, there are many studies that addressed glycemic control and CV risk, whilst the literature on the role of tight glycemic control during ACS is currently poor. Therefore, in this review, we critically discussed the studies that investigated this specific topic. Hyperglycemia is implicated in vascular damage and cardiac myocyte death through different molecular mechanisms as advanced glycation end products, protein kinase C, polyol pathway flux, and the hexosamine pathway. Moreover, high FFA concentrations may be toxic in acute ischemic myocardium due to several mechanisms, thus leading to endothelial dysfunction. A reduction in free fatty acid plasma levels and an increased availability of glucose can be achieved by using a glucose-insulin-potassium infusion (GIKi) during AMI. The GIKi is associated with an improvement of either long-term prognosis or left ventricular mechanical performance. DIGAMI studies suggested blood glucose level as a significant and independent mortality predictor among diabetic patients with recent ACS, enhancing the important role of glucose control in their management. Several mechanisms supporting the protective role of tight glycemic control during ACS, as well as position statements of Scientific Societies, were highlighted.

Published
2018
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43. Effect of a Cooperation Strategy between Primary Care Physicians and Hospital Liver Units on HBV Care in Campania, Italy

Author

Zampino, Rosa, primary, Capoluongo, Nicolina, additional, Boemio, Adriana, additional, Macera, Margherita, additional, Vitrone, Martina, additional, Adinolfi, Luigi Elio, additional, Filippini, Pietro, additional, Sagnelli, Evangelista, additional, Sagnelli, Caterina, additional, Durante-Mangoni, Emanuele, additional, and Coppola, Nicola, additional

Published
2018
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47. Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis

Author

Rinaldi, Luca, primary, Nascimbeni, Fabio, additional, Giordano, Mauro, additional, Masetti, Chiara, additional, Guerrera, Barbara, additional, Amelia, Annalisa, additional, Fascione, Maria Chiara, additional, Ballestri, Stefano, additional, Romagnoli, Dante, additional, Zampino, Rosa, additional, Nevola, Riccardo, additional, Baldelli, Enrica, additional, Iuliano, Natalina, additional, Rosato, Valerio, additional, Lonardo, Amedeo, additional, and Adinolfi, Luigi Elio, additional

Published
2017
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49. Reply to Klein

Author

Tripodi, Marie-Francoise, Adinolfi, Luigi Elio, and Utili, Riccardo

Subjects
Health, Health care industry
Published
2004

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