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2 results on '"Acetohydrazide analogues"'

1. In vitro studies of the antileishmanial activity of the newer 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues

Author

Mohamed Jawed Ahsan, Md Yousuf Ansari, Praveen Kumar, Monika Soni, Sabina Yasmin, Surender Singh Jadav, and Ganesh Chandra Sahoo

Subjects
Acetohydrazide analogues, Antileishmanial activity, Leishmania donovani, Medicine (General), R5-920, Science
Abstract

A series of new 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues (8a-n) were synthesized in search of potential therapeutics for leishmaniasis. All the compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The compounds were further evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani as per the standard protocol reported elsewhere. 2-(2,4-Dichlorophenoxy)-N′-{[4-(morpholin-4-yl)phenyl]methylidene}acetohydrazide (8k) showed the most promising antileishmanial activity with IC50 of 48.10 µM, free from cytotoxicity (>153.08 µM).

Published
2016
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2. In vitro studies of the antileishmanial activity of the newer 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues

Author

Sabina Yasmin, Ganesh Chandra Sahoo, Praveen Kumar, Yousuf Ansari, Mohamed Jawed Ahsan, Monika Soni, and Surender Singh Jadav

Subjects
0301 basic medicine, lcsh:R5-920, biology, Stereochemistry, Acetohydrazide analogues, Aryl, 030106 microbiology, Leishmania donovani, Pharmaceutical Science, Medicine (miscellaneous), Antileishmanial activity, biology.organism_classification, Agricultural and Biological Sciences (miscellaneous), In vitro, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Standard protocol, lcsh:Q, Cytotoxicity, lcsh:Medicine (General), lcsh:Science
Abstract

A series of new 2-(substitutedphenoxy)- N -[(aryl)methylidene]acetohydrazide analogues ( 8a-n ) were synthesized in search of potential therapeutics for leishmaniasis. All the compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The compounds were further evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani as per the standard protocol reported elsewhere. 2-(2,4-Dichlorophenoxy)- N ′-{[4-(morpholin-4-yl)phenyl]methylidene}acetohydrazide ( 8k ) showed the most promising antileishmanial activity with IC 50 of 48.10 µM, free from cytotoxicity (>153.08 µM).

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