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1. Current status of MELCOR 2.2 for fusion safety analyses

Author

Mascari, F., Bersano, A., Adorni, M., D'Ovidio, G., Martín-Fuertes, F., Jin, X.Z., Mazzini, G., Gonfiotti, B., Georgiev, G., Leskovar, M., Bertani, C., Testoni, R., Giannetti, F., D'Onorio, M., Agnello, G., Di Maio, P.A., Angelucci, M., Paci, S., Grippo, G., Fernández-Cosials, K., Dongiovanni, D., and Malicki, M.

Published
2023
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2. Nuclear Fuel Modelling During Power Ramp

Author

Cantini, F., Adorni, M., and D'Auria, FRANCESCO SAVERIO

Subjects
Energy (miscellaneous)
Abstract

Fuel rods operating for several years in a LWR can experience fuel-cladding gap closure as a result of the phenomena due to temperature and irradiation. Local power increase induces circumferential stresses in the cladding as a result of the different expansion in the cladding and the pellet. In presence of corrosive fission products (i.e. Iodine) and beyond specific stress threshold and level of burnup, cracks may grow-up from the internal to the external cladding surface, causing fuel rod failure. The phenomenon, known as pellet cladding interaction-stress corrosion cracking PCI/SCC, or PCI, has been identified as a problem since the 70's. The PWR Super-Ramp experiment (part of OECD/NEA “International Fuel Performance Experiments (IFPE) database”) twenty eight fuel rods behaviour has been simulated using TRANSURANUS code version “v1m1j11”. Two sets (“Reference” and “Improved”) of suitable input decks modelling the fuel rods, based on the available literature are used to run the simulations. Focus is given to the main phenomena which are involved or may influence the cladding failure. Systematic comparison of the code results with the experimental data are performed for the parameters relevant for the PCI phenomenon. Sensitivity calculations on fission gas release models implemented in TRANSURANUS code are also performed in order to address the impact on the results. The results show the ability of TRANSURANUS version “v1m1j11” in conservatively predicting the rods failure due to PCI in PWR fuel and Zircaloy-4 cladding. Increased availability of experimental data would help to perform a deeper analysis.

Published
2022

3. Advanced low grade serous ovarian cancer: A retrospective analysis of surgical and chemotherapeutic management in two high volume oncological centers

Author

Di Lorenzo P., Conteduca V., Scarpi E., Adorni M., Multinu F., Garbi A., Betella I., Grassi T., Bianchi T., Di Martino G., Amadori A., Maniglio P., Strada I., Carinelli S., Jaconi M., Aletti G., Zanagnolo V., Maggioni A., Savelli L., De Giorgi U., Landoni F., Colombo N., Fruscio R., Di Lorenzo, P, Conteduca, V, Scarpi, E, Adorni, M, Multinu, F, Garbi, A, Betella, I, Grassi, T, Bianchi, T, Di Martino, G, Amadori, A, Maniglio, P, Strada, I, Carinelli, S, Jaconi, M, Aletti, G, Zanagnolo, V, Maggioni, A, Savelli, L, De Giorgi, U, Landoni, F, Colombo, N, and Fruscio, R

Subjects
low-grade serous ovarian cancer, Cancer Research, Oncology, primary cytoreduction, adjuvant treatment, residual disease, secondary cytoreductive surgery, neoadjuvant chemotherapy
Abstract

Simple summaryLow-grade serous ovarian cancer (LGSOC) represents an uncommon histotype of serous ovarian cancer (accounting for approximately 5% of all ovarian cancer) with a distinct behavior compared to its high-grade serous counterpart, characterized by a better prognosis and low response rate to chemotherapeutic agents. Similar to high-grade serous ovarian cancer, cytoreductive surgery is considered crucial for patient survival. This retrospective study aimed to analyze the outcomes of women affected by advanced stages (III–IV FIGO) of LGSOC from two high-volume oncological centers for ovarian neoplasm. In particular, we sought to evaluate the impact on survival outcomes of optimal cytoreductive surgery [i.e., residual disease (RD) BackgroundLow-grade serous ovarian cancer (LGSOC) is a rare entity with different behavior compared to high-grade serous (HGSOC). Because of its general low chemosensitivity, complete cytoreductive surgery with no residual disease is crucial in advanced stage LGSOC. We evaluated the impact of optimal cytoreduction on survival outcome both at first diagnosis and at recurrence.MethodsWe retrospectively studied consecutive patients diagnosed with advanced LGSOCs who underwent cytoreductive surgery in two oncological centers from January 1994 to December 2018. Survival curves were estimated by the Kaplan–Meier method, and 95% confidence intervals (95% CI) were estimated using the Greenwood formula.ResultsA total of 92 patients were included (median age was 47 years, IQR 35–64). The median overall survival (OS) was 142.3 months in patients with no residual disease (RD), 86.4 months for RD 1–10 mm and 35.2 months for RD >10 mm (p = 0.002). Progression-free survival (PFS) was inversely related to RD after primary cytoreductive surgery (RD = 0 vs RD = 1–10 mm vs RD >10 mm, p = 0.002). On multivariate analysis, RD 1–10 mm (HR = 2.30, 95% CI 1.30–4.06, p = 0.004), RD >10 mm (HR = 3.89, 95% CI 1.92–7.88, p = 0.0004), FIGO stage IV (p = 0.001), and neoadjuvant chemotherapy (NACT) (p = 0.010) were independent predictors of PFS. RD >10 mm (HR = 3.13, 95% CI 1.52–6.46, p = 0.004), FIGO stage IV (p ConclusionsOptimal cytoreductive surgery improves survival outcomes in advanced stage LGSOCs. When complete debulking is impossible, a RD 10 mm in this setting of patients.

Published
2022

4. Current status of Melcor 2.2 for fusion safety analyses

Author

Mascari, F., Bersano, A., Adorni, M., D`Ovidio, G., Martin-Fuertes, F., Jin, X. Z., Mazzini, G., Gonfiotti, B., Georgiev, G., Leskovar, M., Bertani, C., Testoni, R., Giannetti, F., D`Onorio, M., Agnello, G., Maio, P. A. Di, Angelucci, M., Paci, S., Grippo, G., Malicki, M., Fernandez-Cosials, K., Dongiovanni, D., and Luxat, D.

Subjects
Technology, ddc:600
Published
2022
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5. Un primo contributo alla definizione delle fitocenosi dominate da specie aliene in Italia

Author

Bolpagni, R., Acosta, A. T. C., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A., Genovesi, P., Gentili, R., Gigante, D., Lazzaro, L., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., Lastrucci, L., AA.VV., Bolpagni, R., Acosta, A. T. C., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A., Genovesi, P., Gentili, R., Gigante, D., Lazzaro, L., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E., Pirone, Gianfranco, Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., and Lastrucci, L.

Subjects
Alien species, habitat, vegettion, Italy
Published
2018

6. An assessment of the impacts of invasive alien plants on habitats in Italy: first results from the ISPRA-SISV convention

Author

Lazzaro L., Bolpagni R., Acosta A. T. R., Adorni M., Aleffi M., Allegrezza M., Angiolini C., Assini S. P., Bagella S., Bonari G., Bovio M., Bracco F., Brundu G., Buffa G., Caccianiga M., Carnevali L., Ceschin S., Ciaschetti G, Cogoni A., Di Cecco V., Foggi B., Frattaroli A. R., Genovesi P., Gentili R., Gigante D., Lonati M., Lucchese F., Mainetti A., Mariotti M., Minissale P., Paura B., Pellizzari M., Perrino E. V., Pirone G., Poggio L., Poldini L., Poponessi S., Prisco I., Prosser F., Puglisi M., Rosati L., Selvaggi A., Sottovia L., Spampinato G., Stanisci A., Stinca A., Venanzoni R., Viciani D., Vidali M., Villani C., Lastrucci L., AA.VV., Lazzaro, L., Bolpagni, R., Acosta, A. T. R., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G, Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A. R., Genovesi, P., Gentili, R., Gigante, D., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E. V., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., and Lastrucci, L.

Subjects
Invasive alien plants, habitat, Habitat, invasive alien species, Habitat, invasive alien species
Published
2018

7. Il Reporting ex-Art. 17 degli Habitat di All. I alla Direttiva 92/43/CEE in Italia: metodi, criticità, stato dell'arte e prospettive future

Author

Gigante, D., Selvaggi, A., Acosta, A. T. R., Adorni, M., Allegrezza, M., Angiolini, C., Armiraglio, S., Assini, S., Attorre, F., Bagella, S., Barcella, M., Bazan, G., Bertacchi, A., Bolpagni, R., Bonari, G., Buffa, G., Caccianiga, M., Cacciatori, C., Caria, M. C., Casavecchia, S., Casella, L., Cerabolini, B. E. L., Ciaschetti, G., Ciccarelli, D., Cogoni, A., Cutini, M., De Sanctis, M., De Simone, W., Del Vecchio, S., Di Cecco, V., Di Martino, L., Di Musciano, M., Fantinato, E., Filesi, L., Foggi, B., Forte, L., Frattaroli, A. R., Galdenzi, D., Gangale, C., Gianguzzi, L., Giusso Del Galdo, G., Grignetti, A., Guarino, R., Lasen, C., Maneli, F., Marcenò, C., Mariotti, M. G., Oriolo, G., Paura, B., Perrino, E., Pesaresi, S., Pezzi, G., Pisanu, S., Poponessi, S., Prisco, I., Puglisi, M., Rivieccio, G., Sciandrello, S., Spampinato, G., Stinca, A., Strumia, S., Taffetani, F., Tesei, G., Tomaselli, V., Venanzoni, R., Viciani, D., Villani, M., Wagensommer, R., Zanatta, K., and Angelini, P.

Subjects
Habitat, conservation, Europeand Directive
Published
2019

8. An overview of the Italian forest biodiversity and its conservation level, based on the first outcomes of the 4th Habitat Report ex-Art. 17

Author

Gigante, D., Selvaggi, A., Acosta Alicia, T., Adorni, M., Allegrezza, M., Angiolini, C., Armiraglio, S., Assini, S., Attorre, F., Bagella, S., Barcella, M., Giuseppe Bazan, Bertacchi, A., Bolpagni, R., Bonari, G., Buffa, G., Caccianiga Marco Stefano, Cacciatori, C., Carmela, C., Casavecchia, S., Casella, L., Cerabolini Bruno, E., Ciaschetti, G., Ciccarelli, D., Cogoni, A., Cutini, M., De Sanctis Michele, De Simone Walter, Del Vecchio Silvia, Di Cecco Valter, Di Martino Luciano, Di Musciano Michele, Fantinato, E., Filesi, L., Foggi, B., Forte, L., Frattaroli Anna Rita, Galdenzi, D., Gangale, C., lorenzo gianguzzi, Giusso Del Galdo Gianpietro, Grignetti, A., Riccardo Guarino, Lasen, C., Maneli, F., Marcenò, C., Mariotti Mauro Giorgio, Oriolo, G., Paura, B., Perrino, E., Pesaresi, S., Pezzi, G., Pisanu, S., Poponessi, S., Prisco, I., Puglisi, M., Rivieccio, G., Sciandrello, S., Spampinato, G., Stinca, A., Strumia, S., Taffetani, F., Tesei, G., Tomaselli, V., Venanzoni, R., Viciani, D., Villani, M., Wagensommer Robert Philipp, Zanatta, K., Angelini, P., Società Botanica Italiana, Gigante, Daniela, Selvaggi, Alberto, Acosta Alicia, T. R., Adorni, Michele, Allegrezza, Marina, Angiolini, Claudia, Armiraglio, Stefano, Assini, Silvia, Attorre, Fabio, Bagella, Simonetta, Barcella, Matteo, Bazan, Giuseppe, Bertacchi, Andrea, Bolpagni, Rossano, Bonari, Gianmaria, Buffa, Gabriella, Caccianiga Marco, Stefano, Cacciatori, Cecilia, Caria Maria, Carmela, Casavecchia, Simona, Casella, Laura, Cerabolini Bruno, E. L., Ciaschetti, Giampiero, Ciccarelli, Daniela, Cogoni, Annalena, Cutini, Maurizio, De Sanctis, Michele, De Simone, Walter, Del Vecchio, Silvia, Di Cecco, Valter, Di Martino, Luciano, Di Musciano, Michele, Fantinato, Edy, Filesi, Leonardo, Foggi, Bruno, Forte, Luigi, Frattaroli Anna, Rita, Galdenzi, Diana, Gangale, Carmen, Gianguzzi, Lorenzo, Giusso Del Galdo, Gianpietro, Grignetti, Alessandra, Guarino, Riccardo, Lasen, Cesare, Maneli, Fabio, Marcenò, Corrado, Mariotti Mauro, Giorgio, Oriolo, Giuseppe, Paura, Bruno, Perrino, Enrico, Pesaresi, Simone, Pezzi, Giovanna, Pisanu, Stefania, Poponessi, Silvia, Prisco, Irene, Puglisi, Marta, Rivieccio, Giovanni, Sciandrello, Saverio, Spampinato, Giovanni, Stinca, Adriano, Strumia, Sandro, Taffetani, Fabio, Tesei, Giulio, Tomaselli, Valeria, Venanzoni, Roberto, Viciani, Daniele, Villani, Mariacristina, Wagensommer Robert, Philipp, Zanatta, Katia, Angelini, Paola, and Gigante Daniela, Selvaggi Alberto, Acosta Alicia T.R., Adorni Michele, Allegrezza Marina, Angiolini Claudia, Armiraglio Stefano, Assini Silvia, Attorre Fabio, Bagella Simonetta, Barcella Matteo, Bazan Giuseppe, Bertacchi Andrea, Bolpagni Rossano, Bonari Gianmaria, Buffa Gabriella, Caccianiga Marco Stefano, Cacciatori Cecilia, Caria Maria.Carmela, Casavecchia Simona, Casella Laura, Cerabolini Bruno E.L., Ciaschetti Giampiero, Ciccarelli Daniela, Cogoni Annalena, Cutini Maurizio, De Sanctis Michele, De Simone Walter, Del Vecchio Silvia, Di Cecco Valter, Di Martino Luciano, Di Musciano Michele, Fantinato Edy, Filesi Leonardo, Foggi Bruno, Forte Luigi, Frattaroli Anna Rita, Galdenzi Diana, Gangale Carmen, Gianguzzi Lorenzo, Giusso Del Galdo Gianpietro, Grignetti Alessandra, Guarino Riccardo, Lasen Cesare, Maneli Fabio, Marcenò Corrado, Mariotti Mauro Giorgio, Oriolo Giuseppe, Paura Bruno, Perrino Enrico, Pesaresi Simone, Pezzi Giovanna, Pisanu Stefania, Poponessi Silvia, Prisco Irene, Puglisi Marta, Rivieccio Giovanni, Sciandrello Saverio, Spampinato Giovanni, Stinca Adriano, Strumia Sandro, Taffetani Fabio, Tesei Giulio, Tomaselli Valeria, Venanzoni Roberto, Viciani Daniele, Villani Mariacristina, Wagensommer Robert Philipp, Zanatta Katia, Angelini Paola

Subjects
Habitat, Habitat, Italian forests, Vegetation Science, Natura 2000, Biodiversity conservation, Italian forests
Abstract

In 2019 the 4th Report ex-Art. 17 on the conservation status (CS) of Annex I Habitats of the 92/43/EEC Directive was expected by every EU/28 country, with reference to the period 2013-18. In Italy, the process was in charge to the Italian Institute for Environmental Protection and Research (ISPRA), on behalf of the Ministry for Environment, Land and Sea Protection (MATTM), with the scientific support of the Italian Botanical Society (SBI). A large group of thematic and territorial experts elaborated the available data concerning the 124 types of terrestrial and inland water Habitats present in Italy, 39 of which are represented by Forest Habitats (Group 9),. The main aim of the work was the evaluation of the overall CS of each Habitat by Biogeographic Region (Mediterranean, Continental and Alpine), for a total amount of 294 assessments. A high proportion of these (92, corresponding to 31% of the total) referred to Forest Habitats, including 20 marginal types for which the CS was not requested. The analysis was carried out at different scales: a) administrative territory, through the data contained in the ISPRA database, whose compilation was in charge to the Regions and Autonomous Provinces; b) Natura 2000 site, with the latest updates available (Standard Data Forms updated to 2018); c) national scale, implementing the distribution maps for each Habitat based on the European grid ETRS89-LAEA5210 (10x10 km2 mesh); d) Biogeographic Region, scale of the final assessment. Cartographic outcomes, associated databases and additional data used for the assessments will be available online on the ISPRA Portal as soon as the validation process by the European Commission will be completed. A dedicated archive named "HAB_IT" has been created in the national database "VegItaly" (1), managed by the Italian Society of Vegetation Science, where the phytosociological relevés representative of the various Annex I Habitats in Italy will be archived and freely accessible. An overview of the results regarding the Forest habitats is here provided, including a comparison with the outcomes of the former reporting cycle, the 3rd Report ex-Art. 17 (2). In several cases (e.g. 9120, 91L0), the distribution maps have been remarkably improved due to better knowledge and more fitful interpretation. The conservation status resulted as Favourable (FV) for 6,7%, Inadequate (U1) for 58,7% and Bad (U1) for 32,0% of the 72 assessed forest Habitat types. In no case there was an improvement of the conservation status, while in 6 cases a worsening of the conditions resulted from the data analysis, pointing out the Habitats types with a higher need of action. Similarly to other projects carried out as a team by the network of Annex I Habitat experts of the Italian Botanical Society and the Italian Society for Vegetation Science (e.g. 3, 4), this is another step in the direction of supporting the implementation of the 92/43/EEC "Habitat" Directive in Italy and Europe. On this ground, the high biodiversity of the Italian forest Habitats could be emphasized, however results pointed out that some rare or endemic types (e.g. Alnus cordata or Betula aetnensis-dominated forests) are still scarcely acknowledged by the most prominent EU conservation tools such as the Annex I to the "Habitat" Directive. 1) F. Landucci et al. (2012) Plant Biosyst., 146(4), 756-763 2) P. Genovesi et al. (2014) ISPRA, Serie Rapporti, 194/2014 3) E. Biondi et al. (2009) Società Botanica Italiana, MATTM, D.P.N., http://vnr.unipg.it/habitat/ 4) D. Gigante et al. (2016) Plant Sociology, 53(2), 77-87

Published
2019

9. An overview of the Italian forest biodiversity and its conservation level, based on the first outcomes of the 4th Habitat Report ex-Art. 17. Communication IX

Author

Gigante, D., Selvaggi, A., Acosta, A. T. R., Adorni, M., Allegrezza, M., Angiolini, C., Armiraglio, S., Assini, S., Attorre, F., Bagella, S., Barcella, M., Bazan, G., Bertacchi, A., Bolpagni, R., Bonari, G., Buffa, G., Caccianiga, M., Cacciatori, C., Caria, M. C., Casavecchia, S., Casella, L., Cerabolini, B. E. L., Ciaschetti, G., Ciccarelli, D., Cogoni, A., Cutini, M., De Sanctis, M., De Simone, W., Del Vecchio, S., Di Cecco, V., Di Martino, L., Di Musciano, M., Fantinato, E., Filesi, L., Foggi, B., Forte, L., Frattaroli, A. R., Galdenzi, D., Gangale, C., Gianguzzi, L., Giusso Del Galdo, G., Grignetti, A., Guarino, R., Lasen, C., Maneli, F., Marcenò, C., Mariotti, M. G., Oriolo, G., Paura, B., Perrino, E., Pesaresi, S., Pezzi, G., Pisanu, S., Poponessi, S., Prisco, I., Puglisi, M., Rivieccio, G., Sciandrello, S., Spampinato, G., Stinca, A., Strumia, S., Taffetani, F., Tesei, G., Tomaselli, V., Venanzoni, R., Viciani, D., Villani, M., Wagensommer, R., Zanatta, K., and Angelini, P.

Subjects
Habitat, forests, conservation, monitoring, 92/43/EEC
Published
2019

11. Una valutazione degli impatti delle piante alloctone invasive sugli habitat in Italia: primi risultati dalla convenzione ISPRA-SISV

Author

Lazzaro, L., Acosta, A. T. C., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S. P., Bagella, S., Bolpagni, R., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A., Genovesi, P., Gentili, R., Gigante, D., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, C., and Lastrucci, L.

Subjects
Alien plant, habitat, vegetation, Italy
Published
2018

14. Cellular cholesterol efflux and cholesterol loading capacity of serum: effects of LDL-apheresis

Author

Adorni, M. P., Zimetti, F., Puntoni, M., Bigazzi, F., Sbrana, F., Minichilli, F., Bernini, F., Ronda, N., Favari, E., and Sampietro, T.

Abstract

High LDL-cholesterol (LDL-C) characterizes familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH). LDL-apheresis, used in these patients to reduce LDL-C levels, has been shown to also affect HDL levels and composition. We studied LDL-apheresis effects on six FH and nine FCH subjects’ serum capacity to modulate cellular cholesterol efflux, an index of HDL functionality, and to load macrophages with cholesterol. Serum cholesterol efflux capacity (CEC) and macrophage cholesterol loading capacity (CLC) were measured before, immediately after, and two days after LDL-apheresis. The procedure reduced total cholesterol (TC), LDL-C, and apoB plasma levels (–69%, –80% and –74%, respectively), parameters only partially restored two days later. HDL-C and apoA-I plasma levels, reduced after LDL-apheresis (–27% and –16%, respectively), were restored to almost normal levels two days later. LDL-apheresis reduced serum aqueous diffusion (AD) CEC, SR-BI-CEC, and ABCA1-CEC. AD and SR-BI were fully restored whereas ABCA1-CEC remained low two days later. Sera immediately and two days after LDL-apheresis had a lower CLC than pre-LDL-apheresis sera. In conclusion, LDL-apheresis transiently reduces HDL-C levels and serum CEC, but it also reduces also serum capacity to deliver cholesterol to macrophages. Despite a potentially negative effect on HDL levels and composition, LDL-apheresis may counteract foam cells formation.

Published
2012

15. Notulae to the Italian alien vascular flora: 9

Author

C. Villano, Mauro Fois, Gianmaria Bonari, Michele Mugnai, G. Buccomino, Paolo Castagnini, Nicodemo G. Passalacqua, Alberto Selvaggi, Liliana Bernardo, F. Menini, Marco Sarigu, Andrea Mainetti, M. Aversa, Sergio Buono, Filippo Prosser, Simonetta Fascetti, Nicole Hofmann, Lorenzo Lazzaro, F. Bonali, M. Apruzzese, Marco Pittarello, Giovanni Spampinato, S. Ravetto Enri, Chiara Toffolo, Rodolfo Gentili, A. Ilari, Silvia Paola Assini, J. Lupoletti, G. Tomasi, Lorenzo Pinzani, Giuseppe Brundu, Andrea Milani, Adriano Stinca, Nicola M. G. Ardenghi, Filippo Scafidi, Lina Podda, G. Barberis, Valentina Laface, Mauro Mariotti, Andrea Lallai, Vanessa Lozano, M. Adorni, Gabriele Gheza, Luigi Minuto, Fabrizio Bartolucci, Claudia Turcato, D. Marchetti, Marco Merli, Alessio Bertolli, L. Onnis, Simonetta Peccenini, Duilio Iamonico, Antonio Pica, Giulio Ferretti, A. Di Turi, S. Ceschin, A. Kiraly, Francesco Bracco, Sara Magrini, L. Gubellini, Lorenzo Peruzzi, Giacomo Calvia, Ilaria Bonini, Davide Dagnino, Salvatore Cambria, Saverio Sciandrello, Daniela Longo, Gianmarco Tavilla, Gianluigi Bacchetta, F. Mariani, Michele Lonati, Francesco Roma-Marzio, Carmelo Maria Musarella, Claudia Angiolini, M. Manca, Enrico Banfi, Chiara Nepi, Gianniantonio Domina, Gergely Király, Nicola Olivieri, Giacomo Mei, E. Di Gristina, Leonardo Rosati, Gabriele Galasso, R. Masin, Galasso G., Domina G., Adorni M., Angiolini C., Apruzzese M., Ardenghi N.M.G., Assini S., Aversa M., Bacchetta G., Banfi E., Barberis G., Bartolucci F., Bernardo L., Bertolli A., Bonali F., Bonari G., Bonini I., Bracco F., Brundu G., Buccomino G., Buono S., Calvia G., Cambria S., Castagnini P., Ceschin S., Dagnino D., Di Gristina E., Di Turi A., Fascetti S., Ferretti G., Fois M., Gentili R., Gheza G., Gubellini L., Hofmann N., Iamonico D., Ilari A., Kiraly A., Kiraly G., Laface V.L.A., Lallai A., Lazzaro L., Lonati M., Longo D., Lozano V., Lupoletti J., Magrini S., Mainetti A., Manca M., Marchetti D., Mariani F., Mariotti M.G., Masin R.R., Mei G., Menini F., Merli M., Milani A., Minuto L., Mugnai M., Musarella C.M., Olivieri N., Onnis L., Passalacqua N.G., Peccenini S., Peruzzi L., Pica A., Pinzani L., Pittarello M., Podda L., Prosser F., Enri S.R., Roma-Marzio F., Rosati L., Sarigu M., Scafidi F., Sciandrello S., Selvaggi A., Spampinato G., Stinca A., Tavilla G., Toffolo C., Tomasi G., Turcato C., Villano C., Nepi C., Galasso, G, Domina, G, Adorni, M, Angiolini, C, Apruzzese, M, Ardenghi, N, Assini, S, Aversa, M, Bacchetta, G, Banfi, E, Barberis, G, Bartolucci, F, Bernardo, L, Bertolli, A, Bonali, F, Bonari, G, Bonini, I, Bracco, F, Brundu, G, Buccomino, G, Buono, S, Calvia, G, Cambria, S, Castagnini, P, Ceschin, S, Dagnino, D, Di Gristina, E, Di Turi, A, Fascetti, S, Ferretti, G, Fois, M, Gentili, R, Gheza, G, Gubellini, L, Hofmann, N, Iamonico, D, Ilari, A, Kiraly, A, Kiraly, G, Laface, V, Lallai, A, Lazzaro, L, Lonati, M, Longo, D, Lozano, V, Lupoletti, J, Magrini, S, Mainetti, A, Manca, M, Marchetti, D, Mariani, F, Mariotti, M, Masin, R, Mei, G, Menini, F, Merli, M, Milani, A, Minuto, L, Mugnai, M, Musarella, C, Olivieri, N, Onnis, L, Passalacqua, N, Peccenini, S, Peruzzi, L, Pica, A, Pinzani, L, Pittarello, M, Podda, L, Prosser, F, Enri, S, Roma-Marzio, F, Rosati, L, Sarigu, M, Scafidi, F, Sciandrello, S, Selvaggi, A, Spampinato, G, Stinca, A, Tavilla, G, Toffolo, C, Tomasi, G, Turcato, C, Villano, C, Nepi, C, Galasso, G., Domina, G., Adorni, M., Angiolini, C., Apruzzese, M., Ardenghi, N. M. G., Assini, S., Aversa, M., Bacchetta, G., Banfi, E., Barberis, G., Bartolucci, F., Bernardo, L., Bertolli, A., Bonali, F., Bonari, G., Bonini, I., Bracco, F., Brundu, G., Buccomino, G., Buono, S., Calvia, G., Cambria, S., Castagnini, P., Ceschin, S., Dagnino, D., Di Gristina, E., Di Turi, A., Fascetti, S., Ferretti, G., Fois, M., Gentili, R., Gheza, G., Gubellini, L., Hofmann, N., Iamonico, D., Ilari, A., Kiraly, A., Kiraly, G., Laface, V. L. A., Lallai, A., Lazzaro, L., Lonati, M., Longo, D., Lozano, V., Lupoletti, J., Magrini, S., Mainetti, A., Manca, M., Marchetti, D., Mariani, F., Mariotti, M. G., Masin, R. R., Mei, G., Menini, F., Merli, M., Milani, A., Minuto, L., Mugnai, M., Musarella, C. M., Olivieri, N., Onnis, L., Passalacqua, N. G., Peccenini, S., Peruzzi, L., Pica, A., Pinzani, L., Pittarello, M., Podda, L., Prosser, F., Enri, S. R., Roma-Marzio, F., Rosati, L., Sarigu, M., Scafidi, F., Sciandrello, S., Selvaggi, A., Spampinato, G., Stinca, A., Tavilla, G., Toffolo, C., Tomasi, G., Turcato, C., Villano, C., and Nepi, C.

Subjects
0106 biological sciences, Flora, Alien species, Floristic data, Italy, New combinations, Nomenclature, new combinations, Plant Science, Alien, Biology, 010603 evolutionary biology, 01 natural sciences, floristic data, lcsh:Botany, Alien species floristic data Italy new combinations nomenclature, Alien specie, Ecology, Evolution, Behavior and Systematics, BIO/03 - BOTANICA AMBIENTALE E APPLICATA, Ecology, Alien species, Floristic data, Italy, New combinations, Nomenclature, lcsh:QK1-989, BIO/02 - BOTANICA SISTEMATICA, Settore BIO/03 - Botanica Ambientale E Applicata, nomenclature, New combination, 010606 plant biology & botany
Abstract

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, exclusions, and status changes for Italy or for Italian administrative regions. Furthermore, three new combinations are proposed. Nomenclatural and distribution updates published elsewhere are provided as Suppl. material 1.

Published
2020

16. Impact of invasive alien plants on native plant communities and Natura 2000 habitats: State of the art, gap analysis and perspectives in Italy

Author

Alberto Selvaggi, Mariacristina Villani, Michele Aleffi, Andrea Mainetti, Lorenzo Lazzaro, S. Ceschin, Rodolfo Gentili, V. Di Cecco, Marina Allegrezza, L. Carnevali, Annalena Cogoni, Giovanni Spampinato, Fernando Lucchese, M. Bovio, Michele Lonati, A. Acosta, L. Sottovia, Simonetta Bagella, Francesco Bracco, Silvia Paola Assini, M. Vidali, L. Poggio, Adriano Stinca, Gianfranco Pirone, Bruno Paura, M. Adorni, Piero Genovesi, Anna Rita Frattaroli, Giuseppe Brundu, Bruno Foggi, Enrico V. Perrino, Rossano Bolpagni, Angela Stanisci, Roberto Venanzoni, Marco Caccianiga, Leonardo Rosati, Marta Puglisi, Daniele Viciani, Marcella Maria Mariotti, Gianmaria Bonari, Lorenzo Lastrucci, Daniela Gigante, M. Pellizzari, Livio Poldini, Filippo Prosser, Gabriella Buffa, S. Poponessi, Claudia Angiolini, I. Prisco, Giampiero Ciaschetti, Pietro Minissale, Lazzaro, L, Bolpagni, R, Buffa, G, Gentili, R, Lonati, M, Stinca, A, Acosta, A, Adorni, M, Aleffi, M, Allegrezza, M, Angiolini, C, Assini, S, Bagella, S, Bonari, G, Bovio, M, Bracco, F, Brundu, G, Caccianiga, M, Carnevali, L, Di Cecco, V, Ceschin, S, Ciaschetti, G, Cogoni, A, Foggi, B, Frattaroli, A, Genovesi, P, Gigante, D, Lucchese, F, Mainetti, A, Mariotti, M, Minissale, P, Paura, B, Pellizzari, M, Perrino, E, Pirone, G, Poggio, L, Poldini, L, Poponessi, S, Prisco, I, Prosser, F, Puglisi, M, Rosati, L, Selvaggi, A, Sottovia, L, Spampinato, G, Stanisci, A, Venanzoni, R, Viciani, D, Vidali, M, Villani, M, Lastrucci, L, Lazzaro, L., Bolpagni, R., Buffa, G., Gentili, R., Lonati, M., Stinca, A., Acosta, A. T. R., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Caccianiga, M., Carnevali, L., Di Cecco, V., Ceschin, S., Ciaschetti, G., Cogoni, A., Foggi, B., Frattaroli, A. R., Genovesi, P., Gigante, D., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E. V., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Venanzoni, R., Viciani, D., Vidali, M., Villani, M., and Lastrucci, L.

Subjects
Competition, Ecological impact, Expert survey, Impact mechanism, Impact outcome, Natura 2000 network, Environmental Engineering, 0208 environmental biotechnology, Biodiversity, Introduced species, 02 engineering and technology, Alien, 010501 environmental sciences, Management, Monitoring, Policy and Law, 01 natural sciences, Italy, Plants, Ecosystem, Introduced Species, media_common.cataloged_instance, European union, Waste Management and Disposal, 0105 earth and related environmental sciences, media_common, BIO/03 - BOTANICA AMBIENTALE E APPLICATA, Ecology, Plant community, General Medicine, Plant, Native plant, 020801 environmental engineering, Geography, Habitat, Natura 2000, Settore BIO/03 - Botanica Ambientale e Applicata
Abstract

Invasive alien plants are a major threat to biodiversity and they contribute to the unfavourable conservation status of habitats of interest to the European Community. In order to favour implementation of European Union Regulation no. 1143/2014 on invasive alien species, the Italian Society of Vegetation Science carried out a large survey led by a task force of 49 contributors with expertise in vegetation across all the Italian administrative regions. The survey summed up the knowledge on impact mechanisms of invasive alien plants in Italy and their outcomes on plant communities and the EU habitats of Community Interest, in accordance with Directive no. 92/43/EEC. The survey covered 241 alien plant species reported as having deleterious ecological impacts. The data collected illustrate the current state of the art, highlight the main gaps in knowledge, and suggest topics to be further investigated. In particular, the survey underlined competition as being the main mechanism of ecological impact on plant communities and Natura 2000 habitats. Of the 241 species, only Ailanthus altissima was found to exert an ecological impact on plant communities and Natura 2000 habitats in all Italian regions; while a further 20 species impact up to ten out of the 20 Italian administrative regions. Our data indicate that 84 out of 132 Natura 2000 Habitats (64%) are subjected to some degree of impact by invasive alien plants. Freshwater habitats and natural and semi-natural grassland formations were impacted by the highest number of alien species, followed by coastal sand dunes and inland dunes, and forests. Although not exhaustive, this research is the first example of nationwide evaluation of the ecological impacts of invasive alien plants on plant communities and Natura 2000 Habitats.

Published
2020

17. A first checklist of the alien-dominated vegetation in Italy

Author

Viciani, Daniele, Vidali, Marisa, Gigante, Daniela, Bolpagni, Rossano, Villani, Mariacristina, Acosta, Alicia Teresa Rosario, Adorni, Michele, Aleffi, Michele, Allegrezza, Marina, Angiolini, Claudia, Assini, Silvia, Bagella, Simonetta, Bonari, Gianmaria, Bovio, Maurizio, Bracco, Francesco, Brundu, Giuseppe, Buffa, Gabriella, Caccianiga, Marco, Carnevali, Lucilla, Ceschin, Simona, Ciaschetti, Giampiero, Cogoni, Annalena, Di Cecco, Valter, Foggi, Bruno, Frattaroli, Anna Rita, Genovesi, Piero, Gentili, Rodolfo, Lazzaro, Lorenzo, Lonati, Michele, Lucchese, Fernando, Mainetti, Andrea, Mariotti, Mauro, Minissale, Pietro, Paura, Bruno, Pellizzari, Mauro, Perrino, Enrico Vito, Pirone, Gianfranco, Poggio, Laura, Poldini, Livio, Poponessi, Silvia, Prisco, Irene, Prosser, Filippo, Puglisi, Marta, Rosati, Leonardo, Selvaggi, Alberto, Sottovia, Lucio, Spampinato, Giovanni, Stanisci, Angela, Stinca, Adriano, Venanzoni, Roberto, Lastrucci, Lorenzo, Viciani, D., Vidali, M., Gigante, D., Bolpagni, R., Villani, M., Acosta, A. T. R., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S., Bagella, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Cecco, V. D., Foggi, B., Frattaroli, A. R., Genovesi, P., Gentili, R., Lazzaro, L., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E. V., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., Lastrucci, L., Viciani, D, Vidali, M, Gigante, D, Bolpagni, R, Villani, M, Acosta, A, Adorni, M, Aleffi, M, Allegrezza, M, Angiolini, C, Assini, S, Bagella, S, Bonari, G, Bovio, M, Bracco, F, Brundu, G, Buffa, G, Caccianiga, M, Carnevali, L, Ceschin, S, Ciaschetti, G, Cogoni, A, Di Cecco, V, Foggi, B, Frattaroli, A, Genovesi, P, Gentili, R, Lazzaro, L, Lonati, M, Lucchese, F, Mainetti, A, Mariotti, M, Minissale, P, Paura, B, Pellizzari, M, Perrino, E, Pirone, G, Poggio, L, Poldini, L, Poponessi, S, Prisco, I, Prosser, F, Puglisi, M, Rosati, L, Selvaggi, A, Sottovia, L, Spampinato, G, Stanisci, A, Stinca, A, Venanzoni, R, Lastrucci, L, Viciani, Daniele, Vidali, Marisa, Gigante, Daniela, Bolpagni, Rossano, Villani, Mariacristina, Acosta, Alicia Teresa Rosario, Adorni, Michele, Aleffi, Michele, Allegrezza, Marina, Angiolini, Claudia, Assini, Silvia, Bagella, Simonetta, Bonari, Gianmaria, Bovio, Maurizio, Bracco, Francesco, Brundu, Giuseppe, Buffa, Gabriella, Caccianiga, Marco, Carnevali, Lucilla, Ceschin, Simona, Ciaschetti, Giampiero, Cogoni, Annalena, Di Cecco, Valter, Foggi, Bruno, Frattaroli, Anna Rita, Genovesi, Piero, Gentili, Rodolfo, Lazzaro, Lorenzo, Lonati, Michele, Lucchese, Fernando, Mainetti, Andrea, Mariotti, Mauro, Minissale, Pietro, Paura, Bruno, Pellizzari, Mauro, Perrino, Enrico Vito, Pirone, Gianfranco, Poggio, Laura, Poldini, Livio, Poponessi, Silvia, Prisco, Irene, Prosser, Filippo, Puglisi, Marta, Rosati, Leonardo, Selvaggi, Alberto, Sottovia, Lucio, Spampinato, Giovanni, Stanisci, Angela, Stinca, Adriano, Venanzoni, Roberto, and Lastrucci, Lorenzo

Subjects
BIO/03 - BOTANICA AMBIENTALE E APPLICATA, Plant communitie, Plant communities, Syntaxonomy, Plant culture, biodiversity conservation habitat Invasive Alien Species phytosociology plant communities syntaxonomy threats, Invasive alien species, Biodiversity, Conservation, biodiversity, conservation, habitat, Invasive Alien Species, phytosociology, plant communities, syntaxonomy, threats, SB1-1110, Habitat, QK900-989, Threats, Plant ecology, Invasive alien specie, Phytosociology, Threat, Settore BIO/03 - Botanica Ambientale e Applicata
Abstract

This study provides a first step toward the knowledge of the alien-dominated and co-dominated plant communities present in Italy. The first ever checklist of the alien phytocoenoses described or reported in literature for the Italian territory has been compiled, produced by data-mining in national and local thematic literature. The resulting vegetation-type draft-list has been checked in the light of the most recent syntaxonomic documentation and updated with regards to syntaxonomy and nomenclature, with special reference to the frame proposed in the Italian Vegetation Prodrome. The list includes 27 vascular and one bryophyte vegetation classes, hosting 194 low rank alien-dominated syntaxa. The different vegetation types detected for each syntaxonomic class and macro-vegetation group, defined by physiognomical and ecological attributes, are discussed.

Published
2020

18. Distribution map of Ambrosia artemisiifolia L. (Asteraceae) in Italy

Author

Simonetta Peccenini, F Bonafede, Daniela Bouvet, Rodolfo Gentili, F. Fiandri, G. Faggi, A. Truzzi, F Gilardelli, M. Vignodelli, S. Scortegagna, S. Montanari, T. Wilhalm, Alessandra Ghiani, C. Montagnani, Enzo Bona, P. L. Nimis, L. Bagli, Alberto Selvaggi, Luigi Ghillani, M. Adorni, M. Pellizzari, Nicola M. G. Ardenghi, Filippo Prosser, Elena Barni, Fabrizio Martini, M. Bonini, F. Giordana, R. Masin, Consolata Siniscalco, A. Alessandrini, Rossella Marcucci, V. Morelli, M. Sirotti, Gabriella Buffa, S Ciappetta, Sandra Citterio, E. Romani, D. Saiani, Gentili, R, Gilardelli, F, Bona, E, Prosser, F, Selvaggi, A, Alessandrini, A, Martini, F, Nimis, P, Wilhalm, T, Adorni, M, Ardenghi, N, Barni, E, Bonafede, F, Bonini, M, Bouvet, D, Buffa, G, Ciappetta, S, Giordana, F, Faggi, G, Ghiani, A, Ghillani, L, Marcucci, R, Masin, R, Morelli, V, Montagnani, C, Montanari, S, Peccenini, S, Pellizzari, M, Romani, E, Saiani, D, Scortegagna, S, Sirotti, M, Truzzi, A, Vignodelli, M, Bagli, L, Fiandri, F, Siniscalco, C, Citterio, S, Gilardelli, F., Bona, E., Prosser, F., Selvaggi, A., Alessandrini, A., Martini, F., Nimis, Pierluigi, Wilhalm, T., Adorni, M., Ardenghi, N. M. G., Barni, E., Bonafede, F., Bonini, M., Bouvet, D., Buffa, G., Ciappetta, S., Giordana, F., Faggi, G., Ghiani, A., Ghillani, L., Marcucci, R., Masin, R., Morelli, V., Montagnani, C., Montanari, S., Peccenini, S., Pellizzari, M., Romani, E., Saiani, D., Scortegagna, S., Sirotti, M., Truzzi, A., Vignodelli, M., Bagli, L., Fiandri, F., Siniscalco, C., and Citterio, S.

Subjects
0106 biological sciences, Range (biology), Distribution (economics), Plant Science, 010603 evolutionary biology, 01 natural sciences, Floristics, invasion history, alien species prioritization, black list, control actions, neobiota, control action, Plant science, Black list, Ambrosia artemisiifolia, Ecology, Evolution, Behavior and Systematics, biology, Ecology, business.industry, Alien species prioritization, black list, control actions, invasion history, neobiota, Asteraceae, biology.organism_classification, Alien species prioritization, business, 010606 plant biology & botany, Settore BIO/03 - Botanica Ambientale e Applicata
Abstract

The spread of the invasive and allergenic Ambrosia artemisiifolia L. in Italy was analysed and mapped using distribution data from a wide range of sources. Ambrosia artemisiifolia occupies 1057 floristic quadrants which are mostly distributed in the Po plain. The distribution obtained represents the basis to implement urgent management strategies.

Published
2017

19. Genome-wide Copy-number Alterations in Circulating Tumor DNA as a Novel Biomarker for Patients with High-grade Serous Ovarian Cancer

Author

Davide Ippolito, Maurizio D'Incalci, Robert Fruscio, Martina Delle Marchette, Tommaso Grassi, Giulia Siravegna, Lara Paracchini, Chiara Romualdi, Alessia Inglesi, Marco Adorni, Sergio Marchini, Fabio Landoni, Luca Beltrame, Marta Jaconi, Mariachiara Paderno, Paracchini, L, Beltrame, L, Grassi, T, Inglesi, A, Fruscio, R, Landoni, F, Ippolito, D, Delle Marchette, M, Paderno, M, Adorni, M, Jaconi, M, Romualdi, C, D'Incalci, M, Siravegna, G, and Marchini, S

Subjects
Adult, Diagnostic Imaging, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Multivariate analysis, DNA Copy Number Variations, Somatic cell, Disease, SCNA, Sensitivity and Specificity, Circulating Tumor DNA, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Text mining, Ovarian cancer, Internal medicine, Biomarkers, Tumor, medicine, Humans, Aged, Neoplasm Staging, Aged, 80 and over, Ovarian Neoplasms, business.industry, Liquid Biopsy, Middle Aged, medicine.disease, Combined Modality Therapy, Cystadenocarcinoma, Serous, Serous fluid, Treatment Outcome, 030104 developmental biology, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Neoplasm Grading, business, Genome-Wide Association Study
Abstract

Purpose: High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor heterogeneity. Biomarkers serving to monitor drug response and detect disease recurrence are lacking, a fact which reflects an unmet clinical need. Experimental Design: A total of 185 plasma samples and 109 matched tumor biopsies were collected from 46 patients with HGS-EOC, and analyzed by shallow whole-genome sequencing (sWGS). The percentage of tumor fraction (TF) in the plasma was used to study the biological features of the disease at the time of diagnosis (T0) and correlated with patients' survival. Longitudinal analysis of TF was correlated with CA-125 levels and radiological images to monitor disease recurrence. Results: Gain in the clonal regions, 3q26.2 and 8q24.3, was observed in the 87.8% and 78.05% of plasma samples, suggesting that plasma sWGS mirrors solid biopsies. At T0, multivariate analysis revealed that plasma TF levels were an independent prognostic marker of relapse (P < 0.022). After platinum (Pt)-based treatment, circulating tumor DNA (ctDNA) analysis showed a change in the heterogeneous pattern of genomic amplification, including an increased frequency of amplification, compared with before Pt-based treatment in the 19p31.11 and 19q13.42 regions. TF in serially collected ctDNA samples outperformed CA-125 in anticipating clinical and radiological progression by 240 days (range, 37–491). Conclusions: Our results support the notion that sWGS is an inexpensive and useful tool for the genomic analysis of ctDNA in patients with HGS-EOC to monitor disease evolution and to anticipate relapse better than serum CA-125, the routinely used clinical biomarker. See related commentary by Dhani, p. 2372

Published
2020

20. Reference Architecture and Framework

Author

Barbara Pernici, P. Losi, Carla Simone, Paolo Cappellari, Andrea Maurino, M. Riva, C. Franza, M Adorni, Tiziana Catarci, Claudia Raibulet, Pierluigi Plebani, E. Mussi, C. Pandolfo, Francesco Tisato, Daniela Micucci, A. Limonta, Stefano Modafferi, Davide Ragazzi, R. Torlone, M. Melideo, Antonio Zilli, Gianluca Solazzo, Cinzia Cappiello, A. A. Bianchi, Gianluca Lorenzo, G. Giunta, Francesca Arcelli, V. De Antonellis, L. Negri, Giuseppe Vizzari, M. Brioschi, N. Simeoni, A. Caforio, Andrea Calì, Stefania Bandini, Carlo Batini, Angelo Corallo, Luciano Baresi, Devis Bianchini, Pernici, B, Adorni, M, ARCELLI FONTANA, F, Bandini, S, Baresi, L, Batini, C, Bianchi, A, Bianchini, D, Brioschi, M, Caforio, A, Cal`i, A, Cappellari, P, Cappiello, C, Catarci, T, Corallo, A, De Antonellis, V, Franza, C, Giunta, G, Limonta, A, Lorenzo, G, Losi, P, Maurino, A, Melideo, M, Micucci, D, Modafferi, S, Mussi, E, Negri, L, Pandolfo, C, Plebani, P, Ragazzi, D, Raibulet, C, Riva, M, Simeoni, N, Simone, C, Vizzari, G, Solazzo, G, Tisato, F, Torlone, R, Zilli, A, Adorni, M., Arcelli, F., Bandini, Tullio, Baresi, L., Batini, C., Bianchi, A., Brioschi, M., Caforio, A., Calì, A., Cappellari, P., Cappiello, C., Catarci, T., Corallo, A., De Antonellis, V., Franza, Cosimo, Giunta, G., Limonta, A., Lorenzo, G., Losi, P., Maurino, A., Melideo, M., and Micucci, D.

Subjects
software architecture, business.industry, Multichannel information systems, media_common.quotation_subject, INF/01 - INFORMATICA, Art, reference architecture, architectural model, adaptive information systems, Smart card, Reference architecture, business, Humanities, media_common
Abstract

The goal of the MAIS system is to provide support for flexible and adaptive execution of applications in a distributed, multichannel, mobile information system. In such a system, a fundamental requirement is an ability to describe the continuously evolving execution environment and user characteristics. Service requests are therefore satisfied by considering both the request itself and its provisioning environment. The first part of this chapter presents the general architecture of the MAIS system. The MAIS architecture allows us to define a set of “pluggable” modules which can be composed to provide adaptivity at different levels in the MAIS system. The main architectural components are introduced in Sect. 2.2; more details of the components are provided in the rest of the book. The MAIS reference framework, illustrated in the second part of this chapter, provides the essential basis for all of the adaptive mechanisms that are illustrated in the book. The MAIS reference framework defines a common understanding of the elements of a mobile information system that are used to enable communication among the various modules of a MAIS system during information exchange and service provisioning. The reference framework is composed of a set of models: the functional model, the architectural model, and the context model. These are described in the second part of this chapter.

Published
2006

21. Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study

Author

Fronczek, Jakub, Polok, Kamil, de Lange, Dylan W., Jung, Christian, Beil, Michael, Rhodes, Andrew, Fjølner, Jesper, Górka, Jacek, Andersen, Finn H., Artigas, Antonio, Cecconi, Maurizio, Christensen, Steffen, Joannidis, Michael, Leaver, Susannah, Marsh, Brian, Morandi, Alessandro, Moreno, Rui, Oeyen, Sandra, Agvald-Öhman, Christina, Bollen Pinto, Bernardo, Schefold, Joerg C., Valentin, Andreas, Walther, Sten, Watson, Ximena, Zafeiridis, Tilemachos, Sviri, Sigal, van Heerden, Peter Vernon, Flaatten, Hans, Guidet, Bertrand, Szczeklik, Wojciech, Schmutz, R., Wimmer, F., Eller, P., Joannidis, M., De Buysscher, P., De Neve, N., Oeyen, S., Swinnen, W., Bollen Pinto, B., Abraham, P., Hergafi, L., Schefold, J. C., Biskup, E., Piza, P., Taliadoros, I., Fjølner, J., Dey, N., Sølling, C., Rasmussen, B. S., Christensen, S., Forceville, X., Besch, G., Mentec, H., Michel, P., Mateu, P., Vettoretti, L., Bourenne, J., Marin, N., Guillot, M., Aissaoui, N., Goulenok, C., Thieulot-Rolin, N., Messika, J., Lamhaut, L., Guidet, B., Charron, C., Lauten, A., Sacher, A. L., Brenner, T., Franz, M., Bloos, F., Ebelt, H., Schaller, S. J., Fuest, K., Rabe, C., Dieck, T., Steiner, S., Graf, T., Nia, A. M., Jung, C., Janosi, R. A., Meybohm, P., Simon, P., Utzolino, S., Rahmel, T., Barth, E., Schuster, M., Aidoni, Z., Aloizos, S., Tasioudis, P., Lampiri, K., Zisopoulou, V., Ravani, I., Pagaki, E., Antoniou, A., Katsoulas, T. A., Kounougeri, A., Marinakis, G., Tsimpoukas, F., Spyropoulou, A., Zygoulis, P., Kyparissi, A., Gupta, M., Gurjar, M., Maji, I. M., Hayes, I., Marsh, B., Kelly, Y., Westbrook, A., Fitzpatrick, G., Maheshwari, D., Motherway, C., Negri, G., Spadaro, S., Nattino, G., Pedeferri, M., Boscolo, A., Rossi, S., Calicchio, G., Cubattoli, L., Di Lascio, G., Barbagallo, M., Berruto, F., Codazzi, D., Bottazzi, A., Fumagalli, P., Negro, G., Lupi, G., Savelli, F., Vulcano, G. A., Fumagalli, R., Marudi, A., Lefons, U., Lembo, R., Babini, M., Paggioro, A., Parrini, V., Zaccaria, M., Clementi, S., Gigliuto, C., Facondini, F., Pastorini, S., Munaron, S., Calamai, I., Bocchi, A., Adorni, A., Bocci, M. G., Cortegiani, A., Casalicchio, T., Mellea, S., Graziani, E., Barattini, M., Brizio, E., Rossi, M., Hahn, M., Flaatten, H., Kemmerer, N., Strietzel, H. F., Dybwik, K., Legernaes, T., Klepstad, P., Olaussen, E. B., Olsen, K. I., Brresen, O. M., Bjorsvik, G., Andersen, F. H., Maini, S., Fehrle, L., Czuczwar, M., Krawczyk, P., Ziętkiewicz, M., Nowak, Ł. R., Kotfis, K., Cwyl, K., Gajdosz, R., Biernawska, J., Bohatyrewicz, R., Gawda, R., Grudzień, P., Nasiłowski, P., Popek, N., Cyrankiewicz, W., Wawrzyniak, K., Wnuk, M., Maciejewski, D., Studzińska, D., Żukowski, M., Bernas, S., Piechota, M., Szczeklik, W., Nowak-Kózka, I., Fronczek, J., Serwa, M., Machała, W., Stefaniak, J., Wujtewicz, M., Maciejewski, P., Szymkowiak, M., Adamik, B., Polok, K., Górka, J., Catorze, N., Branco, M. C., Barros, N., Barros, I., Krystopchuk, A., Honrado, T., Sousa, C., Munoz, F., Rebelo, M., Gomes, R., Nunes, J., Dias, C., Fernandes, A. M., Petrisor, C., Constantin, B., Belskiy, V., Boskholov, B., Rodriguez, E., Aguilar, G., Masdeu, G., Jaimes, M. I., Mira, A. P., Bodi, M. A., Mendoza, J. A. B., López-Cuenca, S., Guzman, M. H., Rico-Feijoo, J., Ibarz, M., Alvarez, J. Trenado, Kawati, R., Sivik, J., Nauska, J., Smole, D., Parenmark, F., Lyrén, J., Rockstroh, K., Rydén, S., Spångfors, M., Strinnholm, M., Walther, S., De Geer, L., Nordlund, P., Pålsson, S., Zetterquist, H., Nilsson, A., Thiringer, K., Jungner, M., Bark, B., Nordling, B., Sköld, H., Brorsson, C., Persson, S., Bergström, A., Berkius, J., Holmström, J., van Dijk, I., van Lelyveld-Haas, L. E. M., Jansen, T., Nooteboom, F., van der Voort, P. H. J., de Lange, D., Dieperink, W., de Waard, M. C., de Smet, A. G. E., Bormans, L., Dormans, T., Dempsey, G., Mathew, S. J., Raj, A. S., Grecu, I., Cupitt, J., Lawton, T., Clark, R., Popescu, M., Spittle, N., Faulkner, M., Cowton, A., Williams, P., Elloway, E., Reay, M., Chukkambotla, S., Kumar, R., Al-Subaie, N., Kent, L., Tamm, T., Kajtor, I., Burns, K., Pugh, R., Ostermann, M., Kam, E., Bowyer, H., Smith, N., Templeton, M., Henning, J., Goffin, K., Kapoor, R., Laha, S., Chilton, P., Khaliq, W., Crayford, A., Coetzee, S., Tait, M., Stoker, W., Gimenez, M., Pope, A., Camsooksai, J., Pogson, D., Quigley, K., Ritzema, J., Hormis, A., Boulanger, C., Balasubramaniam, M., Vamplew, L., Burt, K., Martin, D., Craig, J., Prowle, J., Doyle, N., Shelton, J., Scott, C., Donnison, P., Shelton, S., Frey, C., Ryan, C., Spray, D., Barnes, V., Barnes, K., Ridgway, S., Saha, R., Clark, T., Wood, J., Bolger, C., Bassford, C., Lewandowski, J., Zhao, X., Humphreys, S., Dowling, S., Richardson, N., Burtenshaw, A., Stevenson, C., Wilcock, D., Nalapko, Y., Helbok, R., Nollet, J., de Neve, N., Mikačić, M., Bastiansen, A., Husted, A., Dahle, B. E. S., Cramer, C., Ørsnes, D., Thomsen, J. Edelberg, Pedersen, J. J., Enevoldsen, M. Hummelmose, Elkmann, T., Kubisz-Pudelko, A., Collins, A., Hart, C., Randell, G., Filipe, H., Welters, I. D., Evans, J., Lord, J., Jones, J., Ball, J., North, J., Salaunkey, K., De Gordoa, L. Ortiz-Ruiz, Bell, L., Vizcaychipi, M., Mupudzi, M., Lea-Hagerty, M., Spivey, M., Love, N., White, N., Morgan, P., Wakefield, P., Savine, R., Jacob, R., Innes, R., Rose, S., Leaver, S., Mane, T., Ogbeide, V., Baird, Y., Romen, A., Galbois, A., Vinsonneau, C., Thevenin, D., Guerot, E., Savary, G., Chagnon, J. L., Rigaud, J. P., Quenot, J. P., Castaneray, J., Rosman, J., Maizel, J., Tiercelet, K., Hovaere, M. M., Messika, M., Djibré, M., Rolin, N., Burtin, P., Garcon, P., Nseir, S., Valette, X., Horacek, M., Bruno, R. Romano, Allgäuer, S., Dubler, S., Schering, S., Koutsikou, A., Vakalos, A., Raitsiou, B., Flioni, E. N., Neou, E., Papathanakos, G., Koutsodimitropoulos, I., Aikaterini, K., Rovina, N., Kourelea, S., Polychronis, T., Zidianakis, V., Konstantinia, V., Read, C., Martin-Loeches, I., Cracchiolo, A. Neville, Morigi, A., Brusa, S., Elhadi, A., Tarek, A., Khaled, A., Ahmed, H., Belkhair, W. Ali, Cornet, A. D., Gommers, D., van Boven, E., Haringman, J., Haas, L., van den Berg, L., Hoiting, O., de Jager, P., Gerritsen, R. T., Breidablik, A., Slapgard, A., Rime, A. K., Jannestad, B., Sjøbøe, B., Rice, E., Jensen, J. P., Langørgen, J., Tøien, K., Strand, K., Biernacka, A., Kluzik, A., Kudlinski, B., Hymczak, H., Solek-Pastuszka, J., Zorska, J., Krzych, Ł. J., Zukowski, M., Lipińska-Gediga, M., Pietruszko, M., Kozera, N., Sendur, P., Zatorski, P., Galkin, P., Kościuczuk, U., Gola, W., Pinto, A. F., Santos, A. R., Ferreira, I. A., Blanco, J. B., Carvalho, J. T., Maia, J., Candeias, N., Lores, A., Cilloniz, C., Perez-Torres, D., Maseda, E., Prol-Silva, E., Eixarch, G., Gomà, G., Velasco, G. Navarro, Jaimes, M. Irazábal, Villamayor, M. Ibarz, Fernández, N. Llamas, Cubero, P. Jimeno, Tomasa, T., Sjöqvist, A., Schiöler, F., Westberg, H., Thiringer, K. Kleiven, Boroli, F., Eckert, P., Yıldız, I., Yovenko, I., for the VIP1, [missing], VIP2 study group, [missing], Fronczek, Jakub, Polok, Kamil, de Lange, Dylan W, Jung, Christian, Beil, Michael, Rhodes, Andrew, Fjølner, Jesper, Górka, Jacek, Andersen, Finn H, Artigas, Antonio, Cecconi, Maurizio, Christensen, Steffen, Joannidis, Michael, Leaver, Susannah, Marsh, Brian, Morandi, Alessandro, Moreno, Rui, Oeyen, Sandra, Agvald-Öhman, Christina, Bollen Pinto, Bernardo, Schefold, Joerg C, Valentin, Andrea, Walther, Sten, Watson, Ximena, Zafeiridis, Tilemacho, Sviri, Sigal, van Heerden, Peter Vernon, Flaatten, Han, Guidet, Bertrand, Szczeklik, Wojciech, R Schmutz, F Wimmer, P Eller, M Joannidis, P De Buysscher, N De Neve, S Oeyen, W Swinnen, B Bollen Pinto, P Abraham, L Hergafi, J C Schefold, E Biskup, P Piza, I Taliadoros, J Fjølner, N Dey, C Sølling, B S Rasmussen, S Christensen, X Forceville, G Besch, H Mentec, P Michel, P Mateu, P Michel, L Vettoretti, J Bourenne, N Marin, M Guillot, N Aissaoui, C Goulenok, N Thieulot-Rolin, J Messika, L Lamhaut, B Guidet, C Charron, A Lauten, A L Sacher, T Brenner, M Franz, F Bloos, H Ebelt, S J Schaller, K Fuest, C Rabe, T Dieck, S Steiner, T Graf, A M Nia, C Jung, R A Janosi, P Meybohm, P Simon, S Utzolino, T Rahmel, E Barth, C Jung, M Schuster, Z Aidoni, S Aloizos, P Tasioudis, K Lampiri, V Zisopoulou, I Ravani, E Pagaki, A Antoniou, T A Katsoulas, A Kounougeri, G Marinakis, F Tsimpoukas, A Spyropoulou, P Zygoulis, A Kyparissi, M Gupta, M Gurjar, I M Maji, I Hayes, B Marsh, Y Kelly, A Westbrook, G Fitzpatrick, D Maheshwari, C Motherway, G Negri, S Spadaro, G Nattino, M Pedeferri, A Boscolo, S Rossi, G Calicchio, L Cubattoli, G Di Lascio, M Barbagallo, F Berruto, D Codazzi, A Bottazzi, P Fumagalli, G Negro, G Lupi, F Savelli, G A Vulcano, R Fumagalli, A Marudi, U Lefons, R Lembo, M Babini, A Paggioro, V Parrini, M Zaccaria, S Clementi, C Gigliuto, F Facondini, S Pastorini, S Munaron, I Calamai, A Bocchi, A Adorni, M G Bocci, A Cortegiani, T Casalicchio, S Mellea, E Graziani, M Barattini, E Brizio, M Rossi, M Hahn, H Flaatten, N Kemmerer, H F Strietzel, K Dybwik, T Legernaes, P Klepstad, E B Olaussen, K I Olsen, O M Brresen, G Bjorsvik, F H Andersen, S Maini, L Fehrle, M Czuczwar, P Krawczyk, M Ziętkiewicz, Ł R Nowak, K Kotfis, K Cwyl, R Gajdosz, J Biernawska, R Bohatyrewicz, R Gawda, P Grudzień, P Nasiłowski, N Popek, W Cyrankiewicz, K Wawrzyniak, M Wnuk, D Maciejewski, D Studzińska, M Żukowski, S Bernas, M Piechota, W Szczeklik, I Nowak-Kózka, J Fronczek, M Serwa, W Machała, J Stefaniak, M Wujtewicz, P Maciejewski, M Szymkowiak, B Adamik, K Polok, J Górka, N Catorze, M C Branco, N Barros, I Barros, A Krystopchuk, T Honrado, C Sousa, F Munoz, M Rebelo, R Gomes, J Nunes, C Dias, A M Fernandes, C Petrisor, B Constantin, V Belskiy, B Boskholov, E Rodriguez, G Aguilar, G Masdeu, M I Jaimes, A P Mira, M A Bodi, J A B Mendoza, S López-Cuenca, M H Guzman, J Rico-Feijoo, M Ibarz, J Trenado Alvarez, R Kawati, J Sivik, J Nauska, D Smole, F Parenmark, J Lyrén, K Rockstroh, S Rydén, M Spångfors, M Strinnholm, S Walther, L De Geer, P Nordlund, S Pålsson, H Zetterquist, A Nilsson, K Thiringer, M Jungner, B Bark, B Nordling, H Sköld, C Brorsson, S Persson, A Bergström, J Berkius, J Holmström, I van Dijk, L E M van Lelyveld-Haas, T Jansen, F Nooteboom, P H J van der Voort, D de Lange, W Dieperink, M C de Waard, A G E de Smet, L Bormans, T Dormans, G Dempsey, S J Mathew, A S Raj, I Grecu, J Cupitt, T Lawton, R Clark, M Popescu, N Spittle, M Faulkner, A Cowton, P Williams, E Elloway, M Reay, S Chukkambotla, R Kumar, N Al-Subaie, L Kent, T Tamm, I Kajtor, K Burns, R Pugh, M Ostermann, E Kam, H Bowyer, N Smith, M Templeton, J Henning, K Goffin, R Kapoor, S Laha, P Chilton, W Khaliq, A Crayford, S Coetzee, M Tait, W Stoker, M Gimenez, A Pope, J Camsooksai, D Pogson, K Quigley, J Ritzema, A Hormis, C Boulanger, M Balasubramaniam, L Vamplew, K Burt, D Martin, I Grecu, J Craig, J Prowle, N Doyle, J Shelton, C Scott, P Donnison, S Shelton, C Frey, C Ryan, D Spray, C Ryan, V Barnes, K Barnes, S Ridgway, R Saha, L Kent, T Clark, J Wood, C Bolger, C Bassford, A Cowton, J Lewandowski, X Zhao, S Humphreys, S Dowling, N Richardson, A Burtenshaw, C Stevenson, D Wilcock, Y Nalapko, M Joannidis, P Eller, R Helbok, R Schmutz, J Nollet, N de Neve, P De Buysscher, S Oeyen, W Swinnen, M Mikačić, A Bastiansen, A Husted, B E S Dahle, C Cramer, C Sølling, D Ørsnes, J Edelberg Thomsen, J J Pedersen, M Hummelmose Enevoldsen, T Elkmann, A Kubisz-Pudelko, A Pope, A Collins, A S Raj, C Boulanger, C Frey, C Hart, C Bolger, D Spray, G Randell, H Filipe, I D Welters, I Grecu, J Evans, J Cupitt, J Lord, J Henning, J Jones, J Ball, J North, K Salaunkey, L Ortiz-Ruiz De Gordoa, L Bell, M Balasubramaniam, M Vizcaychipi, M Faulkner, M Mupudzi, M Lea-Hagerty, M Reay, M Spivey, N Love, N Spittle, N White, P Williams, P Morgan, P Wakefield, R Savine, R Jacob, R Innes, R Kapoor, S Humphreys, S Rose, S Dowling, S Leaver, T Mane, T Lawton, V Ogbeide, W Khaliq, Y Baird, A Romen, A Galbois, B Guidet, C Vinsonneau, C Charron, D Thevenin, E Guerot, G Besch, G Savary, H Mentec, J L Chagnon, J P Rigaud, J P Quenot, J Castaneray, J Rosman, J Maizel, K Tiercelet, L Vettoretti, M M Hovaere, M Messika, M Djibré, N Rolin, P Burtin, P Garcon, S Nseir, X Valette, C Rabe, E Barth, H Ebelt, K Fuest, M Franz, M Horacek, M Schuster, P Meybohm, R Romano Bruno, S Allgäuer, S Dubler, S J Schaller, S Schering, S Steiner, T Dieck, T Rahmel, T Graf, A Koutsikou, A Vakalos, B Raitsiou, E N Flioni, E Neou, F Tsimpoukas, G Papathanakos, G Marinakis, I Koutsodimitropoulos, K Aikaterini, N Rovina, S Kourelea, T Polychronis, V Zidianakis, V Konstantinia, Z Aidoni, B Marsh, C Motherway, C Read, I Martin-Loeches, A Neville Cracchiolo, A Morigi, I Calamai, S Brusa, A Elhadi, A Tarek, A Khaled, H Ahmed, W Ali Belkhair, A D Cornet, D Gommers, D de Lange, E van Boven, J Haringman, L Haas, L van den Berg, O Hoiting, P de Jager, R T Gerritsen, T Dormans, W Dieperink, A Breidablik, A Slapgard, A K Rime, B Jannestad, B Sjøbøe, E Rice, F H Andersen, H F Strietzel, J P Jensen, J Langørgen, K Tøien, K Strand, M Hahn, P Klepstad, A Biernacka, A Kluzik, B Kudlinski, D Maciejewski, D Studzińska, H Hymczak, J Stefaniak, J Solek-Pastuszka, J Zorska, K Cwyl, Ł J Krzych, M Zukowski, M Lipińska-Gediga, M Pietruszko, M Piechota, M Serwa, M Czuczwar, M Ziętkiewicz, N Kozera, P Nasiłowski, P Sendur, P Zatorski, P Galkin, R Gawda, U Kościuczuk, W Cyrankiewicz, W Gola, A F Pinto, A M Fernandes, A R Santos, C Sousa, I Barros, I A Ferreira, J B Blanco, J T Carvalho, J Maia, N Candeias, N Catorze, V Belskiy, A Lores, A P Mira, C Cilloniz, D Perez-Torres, E Maseda, E Rodriguez, E Prol-Silva, G Eixarch, G Gomà, G Aguilar, G Navarro Velasco, M Irazábal Jaimes, M Ibarz Villamayor, N Llamas Fernández, P Jimeno Cubero, S López-Cuenca, T Tomasa, A Sjöqvist, C Brorsson, F Schiöler, H Westberg, J Nauska, J Sivik, J Berkius, K Kleiven Thiringer, L De Geer, S Walther, F Boroli, J C Schefold, L Hergafi, P Eckert, I Yıldız, I Yovenko, Y Nalapko, R Pugh, and Critical Care

Subjects
Male, Short term mortality, Critical Care and Intensive Care Medicine, Cohort Studies, 0302 clinical medicine, kwetsbaarheid, Medicine and Health Sciences, 80 and over, Medicine, 610 Medicine & health, Prospective cohort study, Correlation of Data, 11 Medical and Health Sciences, Aged, 80 and over, OUTCOMES, Intensive care units, Frailty, VIP1, Aged,&nbsp, Medical emergencies. Critical care. Intensive care. First aid, Scale (social sciences), Female, prospectief onderzoek, Life Sciences & Biomedicine, CRITICALLY-ILL PATIENTS, Study groups, medicine.medical_specialty, Anestesi och intensivvård, 80 jaar en ouder, INTENSIVE-CARE, BED AVAILABILITY, NO, 03 medical and health sciences, Critical Care Medicine, Intensive care, sterfte, General & Internal Medicine, Humans, Aged, Prospective studies, Mortality, In patient, ddc:610, Intensive Care Units, Logistic Models, Prospective Studies, Science & Technology, Anesthesiology and Intensive Care, business.industry, RC86-88.9, Research, 030208 emergency & critical care medicine, ADULTS, Aged, 80 and over, Emergency & Critical Care Medicine, 030228 respiratory system, intensivecareafdelingen, Critical illness, Emergency medicine, VIP2 study group, &nbsp, CRITICAL ILLNESS, business
Abstract

Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient’s age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. Results The median age in the sample of 7487 consecutive patients was 84 years (IQR 81–87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p p Conclusion Knowledge about a patient’s frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2)

Published
2021

22. Global and regional IUCN Red List assessments: 7

Author

Daniele Viciani, Simone Orsenigo, Filippo Prosser, Mariacristina Villani, Stefano Armiraglio, Chiara Montagnani, Alberto Selvaggi, Matilde Gennai, Sara Magrini, Giuseppe Fenu, Miris Castello, Luigi Forte, A. Alessandrini, Pietro Medagli, Robert P. Wagensommer, M. Adorni, Orsenigo, S., Adorni, M., Alessandrini, A., Armiraglio, S., Castello, M., Forte, L., Gennai, M., Magrini, S., Medagli, P., Montagnani, C., Prosser, F., Selvaggi, A., Villani, M., Viciani, D., Wagensommer, R. P., and Fenu, G.

Subjects
0106 biological sciences, Extinction risk, Conservation, Plant Science, IUCN protocol, Threats, 010603 evolutionary biology, 01 natural sciences, lcsh:QK1-989, Fishery, Geography, lcsh:Botany, IUCN Red List, Ecology, Evolution, Behavior and Systematics, 010606 plant biology & botany
Abstract

In this contribution, the conservation status assessment of four vascular plants according to IUCN categories and criteria are presented. It includes the assessments of Aurinialeucadea (Guss.) K.Koch, Chondrillachondrilloides (Ard.) H.Karst., Daphnecneorum L., and Ophioglossumazoricum C.Presl at regional level (Italy).

Published
2019

23. Informing predictive models against Students Dropout

Author

Andrea Zanellati, Stefano Pio Zingaro, Francesca Del Bonifro, Maurizio Gabbrielli, Olivia Levrini, Chiara Panciroli, G. Adorni, M. Allegra, S. Gaglio, M. Gentile, N. Scarabottolo, Andrea Zanellati, Stefano Pio Zingaro, Francesca Del Bonifro, Maurizio Gabbrielli, Olivia Levrini, and Chiara Panciroli

Subjects
Machine Learning, Predictive Analytic Model, Skills assessment, Artificial Intelligence, Dropout, School system
Abstract

Students’ dropout is a complex widespread phenomenon which often lead to conditions of social, educational and professional exclusion. The design of Early Predictive Analytic Models can be a valid tool to counteract this phenomenon, which can be further enhanced by using Machine Learning. In this position paper we aim to contribute with two main points. First of all, we introduce the prominent position of the skills assessment, considered both as a target or as input data for the model, as essential integration to demographic and of economic, social and cultural status variables, often used as predictors for dropout risk. This leads us also to give a definition of implicit dropout, i.e. failure to achieve the expected skills, applicable in different educational contexts. Furthermore, we highlight the importance of integrate the predictive models in a broader framework described as a sequence of phases. The framework stresses the need to make the model “informed” at three levels: a reference pedagogical theory (a theory-laden dimension in a data-intensive approach); the persistence of the initial information and their integration together with the life cycle of the model (its creation, use and update); the guidelines to enable the explainability and transparency of the model outcomes, in accordance with the principles of Trustworthy AI. These contributions are presented both through an abstract description and an undergoing case study in Italian school system.

Published
2021

24. Richer, greener, and more thermophilous? – a first overview of global warming induced changes in the Italian alpine plant communities within the new GLORIA ITALIA NETWORK

Author

Francesco Porro, Simone Orsenigo, Thomas Abeli, Andrea Mondoni, Anna Corli, Fiona J. White, Silvano Lodetti, Marcello Tomaselli, Alessandro Petraglia, Michele Carbognani, Matteo Gualmini, T’ai G. W. Forte, Brigitta Erschbamer, Lena Nicklas, Pau Carnicero, Martin Mallaun, Peter Unterluggauer, Angela Stanisci, Carmen Giancola, Luciano di Martino, Elena Barni, Ludovica Oddi, Umberto Morra di Cella, Rodolfo Gentili, Roberto Dellavedova, Michele Adorni, Harald Pauli, Graziano Rossi, Porro, F, Orsenigo, S, Abeli, T, Mondoni, A, Corli, A, White, Fj, Lodetti, S, Tomaselli, M, Petraglia, A, Carbognani, M, Gualmini, M, Forte, Tgw, Erschbamer, B, Nicklas, L, Carnicero, P, Mallaun, M, Unterluggauer, P, Stanisci, A, Giancola, C, di Martino, L, Barni, E, Oddi, L, di Cella, Um, Gentili, R, Dellavedova, R, Adorni, M, Pauli, H, Rossi, G, White, F, Forte, T, and Morra di Cella, U

Subjects
BIO/03 - BOTANICA AMBIENTALE E APPLICATA, Apennine, Apennines, Alps, Plant Science, Biomonitoring, citizen science, climate change, plant diversity, BIO/01 - BOTANICA GENERALE, Alp, Ecology, Evolution, Behavior and Systematics
Abstract

We announce the formation of the “GLORIA ITALIA NETWORK” and present an overview of the Italian alpine plant communities changes that have occurred in the last 20 years. This network will provide coordination between Italian GLORIA sites and enhance public awareness of changes in alpine plant diversity under climate change.

Published
2021

25. Impact of Bevacizumab-containing Primary Treatment on Outcome of Recurrent Ovarian Cancer: An Italian Study

Author

Anna Maria Ferrero, Valentina Zizioli, Enrico Sartori, Stefania Cosio, Andrea Lissoni, Fabio Landoni, Marco Adorni, Angiolo Gadducci, Gadducci, A, Cosio, S, Lissoni, A, Zizioli, V, Adorni, M, Ferrero, A, Landoni, F, and Sartori, E

Subjects
Oncology, Adult, Cancer Research, medicine.medical_specialty, recurrence, Bevacizumab, Paclitaxel, medicine.medical_treatment, Carcinoma, Ovarian Epithelial, chemotherapy, complete response, Carboplatin, chemistry.chemical_compound, Epithelial ovarian cancer, bevacizumab, carboplatin, paclitaxel, primary debulking surgery, Aged, Antineoplastic Combined Chemotherapy Protocols, Cytoreduction Surgical Procedures, Female, Humans, Italy, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Ovarian Neoplasms, Retrospective Studies, Survival Rate, Treatment Outcome, Ovarian Epithelial, Internal medicine, medicine, Chemotherapy, Performance status, business.industry, Carcinoma, General Medicine, Serous fluid, Neoplasm Recurrence, Local, chemistry, Recurrent Ovarian Cancer, Primary treatment, business, medicine.drug
Abstract

Background/Aim: The aim of the study was to assess the outcome of advanced ovarian cancer patients who i) underwent primary surgery followed by carboplatin/paclitaxel-based chemotherapy with or without bevacizumab, ii) were in complete response after chemotherapy, iii) and subsequently recurred. Patients and Methods: The hospital records of 138 complete responders after chemotherapy with (n=58) or without (n=80) bevacizumab were reviewed. Results: Both survival after recurrence and overall survival were related to age (=61 vs. >61 years, p=0.002 and p=0.0001), performance status (0 vs. =1, p=0.002 and p=0.001), histotype (serous vs. non serous, p=0.005 and p=0.01), time to recurrence (=12 vs.

Published
2020

26. Verso una checklist della vegetazione alloctona in Italia

Author

S. Bagella, D. Viciani, M. Vidali, D. Gigante, R. Bolpagni, M. Villani, A. T. R. Acosta, M. Adorni, M. Aleffi, M. Allegrezza, C. Angiolini, S. Assini, G. Bonari, M. Bovio, F. Bracco, G. Brundu, G. Buffa, M. Caccianiga, L. Carnevali, S. Ceschin, G. Ciaschetti, A. Cogoni, V. Di Cecco, B. Foggi, A. R. Frattaroli, P. Genovesi, R. Gentili, L. Lazzaro, M. Lonati, F. Lucchese, A. Mainetti, M. Mariotti, P. Minissale, B. Paura, M. Pellizzari, E. V. Perrino, G. Pirone, L. Poggio, L. Poldini, S. Poponessi, I. Prisco, F. Prosser, M. Puglisi, L. Rosati, A. Selvaggi, L. Sottovia, G. Spampinato, A. Stanisci, A. Stinca, R. Venanzoni, L. Lastrucci, Bagella, S., Viciani, D., Vidali, M., Gigante, D., Bolpagni, R., Villani, M., Acosta, A. T. R., Adorni, M., Aleffi, M., Allegrezza, M., Angiolini, C., Assini, S., Bonari, G., Bovio, M., Bracco, F., Brundu, G., Buffa, G., Caccianiga, M., Carnevali, L., Ceschin, S., Ciaschetti, G., Cogoni, A., Di Cecco, V., Foggi, B., Frattaroli, A. R., Genovesi, P., Gentili, R., Lazzaro, L., Lonati, M., Lucchese, F., Mainetti, A., Mariotti, M., Minissale, P., Paura, B., Pellizzari, M., Perrino, E. V., Pirone, G., Poggio, L., Poldini, L., Poponessi, S., Prisco, I., Prosser, F., Puglisi, M., Rosati, L., Selvaggi, A., Sottovia, L., Spampinato, G., Stanisci, A., Stinca, A., Venanzoni, R., and Lastrucci, L.

Published
2019

27. Lomitapide affects HDL composition and function

Author

J.E. Roeters van Lennep, Monique T. Mulder, Maria Pia Adorni, Laura Calabresi, Angelo B. Cefalù, Franco Bernini, R. Yahya, Eric J.G. Sijbrands, Elda Favari, Monica Gomaraschi, Maurizio Averna, Adrie J.M. Verhoeven, Francesca Zimetti, Yahya, R., Favari, E., Calabresi, L., Verhoeven, A., Zimetti, F., Adorni, M., Gomaraschi, M., Averna, M., Cefalù, A., Bernini, F., Sijbrands, E., Mulder, M., Roeters van Lennep, J., and Internal Medicine

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Settore MED/09 - Medicina Interna, HDL, Homozygous familial hypercholesterolemia, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Hyperlipoproteinemia Type II, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Humans, Medicine, In patient, Clinical efficacy, Cholesterol, business.industry, Cholesterol, HDL, Homozygote, nutritional and metabolic diseases, Cholesterol, LDL, Cholesterol efflux capacity, Atherosclerosis, medicine.disease, Cholesterol lowering drugs, Lomitapide, Phenotype, Treatment Outcome, 030104 developmental biology, Endocrinology, chemistry, Benzimidazoles, Female, lipids (amino acids, peptides, and proteins), Composition (visual arts), Cholesterol lowering drug, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lipoproteins, HDL, Cardiology and Cardiovascular Medicine, business, ATP Binding Cassette Transporter 1
Abstract

Background Lomitapide reduces low-density lipoprotein-cholesterol (LDL-C) but also high-density lipoprotein-cholesterol (HDL-C) levels. The latter may reduce the clinical efficacy of lomitapide. We investigated the effect of lomitapide on HDL-C levels and on cholesterol efflux capacity (CEC) of HDL in patients with homozygous familial hypercholesterolemia (HoFH). Methods and results Four HoFH patients were treated with increasing dosages of lomitapide. Lomitapide decreased LDL-C (range −34 to −89%). Total HDL-C levels decreased (range −16 to −34%) with a shift to buoyant HDL. ABCA1-mediated CEC decreased in all patients (range −39 to −99%). The changes of total, ABCG1- and SR-BI-mediated CEC were less consistent. Conclusion Lomitapide decreased LDL-C and HDL-C levels. Our report raises the hypothesis that the anti-atherogenic potential of HDL seems to be unaffected as total CEC did not seem to change consistently. Combined with the reduction of atherogenic lipoproteins, the net effect of lomitapide appears to be beneficial in HoFH patients.

Published
2016

28. Restoring population structure and dynamics in translocated species: learning from wild populations

Author

M. Adorni, Ilda Vagge, Gilberto Parolo, Paolo Cauzzi, Graziano Rossi, Simone Orsenigo, Thomas Abeli, Abeli, Thoma, Cauzzi, Paolo, Rossi, Graziano, Adorni, Michele, Vagge, Ilda, Parolo, Gilberto, Orsenigo, Simone, Cauzzi, P., Adorni, M., Vagge, I., Parolo, G., and Orsenigo, S.

Subjects
0106 biological sciences, Leucojum aestivum, Population, Biodiversity, Density, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, Population density, Pollinator attraction, education, Fragmentation (reproduction), education.field_of_study, Habitat fragmentation, Ecology, Reintroduction, Reproduction, food and beverages, biology.organism_classification, Plant ecology, 010606 plant biology & botany, Woody plant
Abstract

Conservation of Leucojum aestivum, a wetland-dependent species distributed in Europe and west Asia, should aim to reduce the fragmentation of wild stands, through the establishment of new populations. However, density-dependent dynamics occur in L. a estivum. For instance, fruit set and seed set increase with increasing plant density. In this study, we evaluate the effect of plant density on translocation success of two recently established populations of L. a estivum. Twenty-six populations of L. a estivum were investigated in northern Italy to find out differences in population traits (size, density, age structure, and reproductive performance) between populations from different habitats. Data obtained were used to establish two new populations of the species differing for population density (high H, mirroring the typical plant density of a wild population in Salix alba woods and low L, in which plant density was halved compared to H), to evaluate the role of density-dependent dynamics on the translocation success. 4 years after the translocation, H produced seedlings, while L did not. Moreover, H produced a significantly higher number of fruits per fruiting plant and higher fruit set. Seed set was also greater in H than in L, while mortality was greater in L than in H, but differences were not significant. Our results suggest that population density is an important factor to account for in newly established populations, especially in those species showing density-dependent population dynamics. Moreover, the imitation of successful within-population dynamics occurring in natural stable populations may increase the translocation success.

Published
2015

29. Notulae to the Italian native vascular flora: 1

Author

Lorenzo Peruzzi, Luigi Ghillani, Nicola M. G. Ardenghi, Chiara Nepi, Gianniantonio Domina, G. Gestri, Franco Fenaroli, G. Barberis, Francesco Scutellà, Gianni Bedini, Nicola Olivieri, Günter Gottschlich, Fabrizio Bartolucci, Valerio Lazzeri, Gianluca Nicolella, Giovanni Russo, Gianmaria Bonari, Adriano Stinca, Francesco Angiulli, Robert P. Wagensommer, Giuseppe Pisani, M. Adorni, A. Alessandrini, Mauro Iberite, Francesco Roma-Marzio, Enrico V. Perrino, Giuseppe Silletti, Mario Calbi, Enrico Banfi, Marta Latini, Gabriele Galasso, Bartolucci, F, Domina, G, Adorni, M, Alessandrini, A, Angiulli, F, Ardenghi, NMG, Banfi, E, Barberis, G, Bedini, G, Bonari, G, Calbi, M, Fenaroli, F, Galasso, G, Gestri, G, Ghillani, L, Gottschlich, G, Iberite, M, Latini, M, Lazzeri, V, Nicolella, G, Olivieri, N, Perrino, E, Peruzzi, L, Pisani, G, Roma-Marzio, F, Russo, G, Scutellà, F, Silletti, G, Stinca, A, Wagensommer, R, and Nepi, C

Subjects
0106 biological sciences, 0301 basic medicine, Flora, Floristic data, Italy, Settore BIO/02 - Botanica Sistematica, Zoology, Floristic data, Biology, 010603 evolutionary biology, 01 natural sciences, lcsh:QK1-989, 03 medical and health sciences, 030104 developmental biology, Italy, lcsh:Botany, Settore BIO/03 - Botanica Ambientale E Applicata
Abstract

In this contribution, new data concerning the Italian distribution of native vascular flora are presented. It includes new records, exclusions, and confirmations pertaining to the Italian administrative regions for taxa in the genera Arundo, Bromopsis, Cistus, Crocus, Festuca, Galeopsis, Genista, Lamium, Leucanthemum, Nerium, Orobanche, Peucedanum, Pilosella, Polycnemum, Stipa and Viola.

Published
2016

30. Notulae to the Italian alien vascular flora: 2

Author

Francesco Roma-Marzio, Fabrizio Buldrini, Mirella Benedetta Campochiaro, Gino Palladino, Sergio Bangoni, Sergio Picollo, Alessandro Rosiello, F Mantino, Federico Selvi, Fabio Conti, Milena Villa, Carlo Argenti, Chiara Nepi, Gianniantonio Domina, C. Gangale, C. Santini, Alessandra Pepe, Lorenzo Peruzzi, Luigi Ghillani, Nicola Olivieri, Domenico Puntillo, Marziano Pascale, Carmen Novaro, Antonia Cristaudo, Giovanni Astuti, Lorenzo Cecchi, Mauro Mariotti, Günter Gottschlich, Luigi Forte, Fabrizio Bartolucci, Adriano Stinca, Francesco Saverio D’Amico, Filippo Scafidi, Anna Scoppola, Giovanni Russo, Franz-Georg Dunkel, M. Adorni, Enrico V. Perrino, Giuseppe D’Auria, Francesca Carruggio, Emilio Di Gristina, Galasso, Gabriele, Domina, Gianniantonio, Ardenghi, Nicola Maria Giuseppe, Arrigoni, Pierfranco, Banfi, Enrico, Bartolucci, Fabrizio, Bonari, Gianmaria, Buccomino, Giovanni, Ciaschetti, Giampiero, Conti, Fabio, Coppi, Andrea, Di Cecco, Valter, Di Martino, Luciano, Guiggi, Alessandro, Lastrucci, Lorenzo, Leporatti, Maria Lucia, López Tirado, Javier, Maiorca, Giovanni, Mossini, Sara, Olivieri, Nicola, Pennesi, Riccardo, Romiti, Bruno, Scoppola, Anna, Soldano, Adriano, Stinca, Adriano, Verloove, Filip, Villa, Milena, Nepi, Chiara, Bartolucci, F, Domina, G, Adorni, M, Argenti, C, Astuti, G, Bangoni, S, Buldrini, F, Campochiaro, MB, Carruggio, F, Cecchi, L, Conti, F, Cristaudo, A, D’Amico, FS, D'Auria, G, Di Gristina, E, Dunkel, F-G, Forte, L, Gangale, C, Ghillani, L, Gottschlich, G, Mantino, F, Mariotti, M, Novaro, C, Olivieri, N, Palladino, G, Pascale, M, Pepe, A, Perrino, EV, Peruzzi, L, Picollo, S, Puntillo, D, Roma-Marzio, F, Rosiello, A, Russo, G, Santini, C, Selvi, F, Scafidi, F, Scoppola, A, Stinca, A, Villa, M, Nepi, C, Fabrizio Bartolucci, Gianniantonio Domina, Michele Adorni, Carlo Argenti, Giovanni Astuti, Sergio Bangoni, Fabrizio Buldrini, Mirella Benedetta Campochiaro, Francesca Carruggio, Lorenzo Cecchi, Fabio Conti, Antonia Cristaudo, Francesco Saverio D’Amico, Giuseppe D’Auria, Emilio Di Gristina, Franz-Georg Dunkel, Luigi Forte, Carmen Gangale, Luigi Ghillani, Günter Gottschlich, Francesca Mantino, Mauro Mariotti, Carmen Novaro, Nicola Olivieri, Gino Palladino, Maurizio Pascale, Alessandra Pepe, Enrico Vito Perrino, Lorenzo Peruzzi, Sergio Picollo, Domenico Puntillo, Francesco Roma-Marzio, Alessandro Rosiello, Giovanni Russo, Claudio Santini, Federico Selvi, Filippo Scafidi, Anna Scoppola, Adriano Stinca, Milena Villa, Chiara Nepi, Galasso, G, Ardenghi, NMG, Arrigoni, P, Banfi, E, Bartolucci, F., Bonari, G., Buccomino, G, Ciaschetti, G, Coppi, A, Di Cecco, V, Di Martino, L, Guiggi, A, Lastrucci, L, Leporatti, M., López Tirado, J, Maiorca, G, Mossini, S, Pennesi, R, Romiti, B, Soldano, A, and Verloove, F

Subjects
0106 biological sciences, new combination, Clerodendrum, Ulmus, Lantana, Ligustrum, Ageratum, Aster, Buddleja, Cedrus, Centranthus, Cephalotaxus, Clerodendrum, Cotoneaster, Cyperus, Honorius, Lantana, Ligustrum, Morus, Muscari, Oenothera, Opuntia, Platycladus, Plumbago, Pseudotsuga, Sedum, Sporobolus, Stachys, Ulmus, Yucca, Zoology, Alien, Plant Science, Ageratum, Platycladus, Biology, Centranthus, 010603 evolutionary biology, 01 natural sciences, Sedum, Cephalotaxus, Sporobolus, lcsh:Botany, Yucca, Cyperus, Cedrus, Ecology, Evolution, Behavior and Systematics, Aster, Plumbago, Floristic data, Italy, Settore BIO/02 - Botanica Sistematica, Honorius, Opuntia, Floristic data, Cotoneaster, Muscari, Pseudotsuga, lcsh:QK1-989, Geography, Italy, Oenothera, Settore BIO/03 - Botanica Ambientale E Applicata, Italian Flora, Stachys, Morus, Buddleja, 010606 plant biology & botany
Abstract

In this contribution, new data concerning the Italian distribution of alien vascular flora are presented. It includes new records, exclusions and confirmations for Italy or for Italian administrative regions for taxa in the genera Ageratum, Aster, Buddleja, Cedrus, Centranthus, Cephalotaxus, Clerodendrum, Cotoneaster, Cyperus, Honorius, Lantana, Ligustrum, Morus, Muscari, Oenothera, Opuntia, Platycladus, Plumbago, Pseudotsuga, Sedum, Sporobolus, Stachys, Ulmus and Yucca. A nomen novum, Stachys talbotii, is proposed as a replacement name for Sideritis purpurea.

Published
2016

31. Middleware and Architectural Reflection

Author

S. Tucci Piergiovanni, Roberto Baldoni, A. Limonta, Carla Simone, P. Losi, Francesca Arcelli, A. Virgillito, Leonardo Querzoni, Carlo Marchetti, Alessia Milani, Roberto Beraldi, Giuseppe Vizzari, Claudia Raibulet, Marcello Sarini, M Adorni, Marco Locatelli, Francesco Tisato, Pernici, B, Adorni, M, ARCELLI FONTANA, F, Baldoni, R, Beraldi, R, Limonta, A, Locatelli, M, Losi, P, Marchetti, C, Milani, A, Querzoni, L, Tucci Piergiovanni, S, Raibulet, C, Sarini, M, Simone, C, Tisato, F, Virgillito, A, and Vizzari, G

Subjects
Computer architecture, middleware design, Computer science, Middleware, architectural reflection, Middle tier, MAIS project, Reflection (computer graphics)
Abstract

The overall goal of the MAIS framework is to support services that are capable of adapting their behavior to changing requirements, environments, user profiles and platforms, in order to provide the user with a suitable quality of service (QoS) [112, 181, 292]. To accomplish this goal, both the front-end and the back-end MAIS environment exploit knowledge about the architecture and configuration of the underlying platform. By platform we mean of all the hardware and software system objects that support the services, for example computing nodes, interaction devices, software components and communication networks. Applications usually rely on abstractions that expose the functional aspects of the system objects. For instance, an application can display something, or send a request through a communication service. System objects also exhibit non functional aspects: in particular, basic QoS features such as bandwidth, availability, screen size, memory size, and battery level [23, 246]. Such features are subject to changes, the rate of which can go from static (e.g., the screen size of a user device) to highly dynamic (e.g., the transfer rate of a network service). In any case, the QoS of the system objects are unknown when the software components that implement the services are being developed. Therefore, in order to provide an adaptive service, such components must be capable of observing and (if possible) of controlling the QoS of the system objects they rely on [24, 25, 26]. Unfortunately, QoS is usually hidden from high-level software components. Sometimes it can be managed via tricky low-level mechanisms. In any case, there are no high-level abstractions that allow an object's QoS to be observed and controlled by high-level, platform-independent software components. To fill this gap, the MAIS project exploits a reflective architecture. The architecture is "reflective" because it allows high-level software components to observe and control the features and the inner state of the system itself. System objects are modeled by meta objects (reflective objects, or R Objects, see [251]) which expose, at a suitable level of abstraction, their meaningful features in terms of QoS. System objects and R Objects are causally connected [241]. The existence of a causal connection means that a state change in the system object causes a state change in the corresponding R Object, and vice versa. Figure 4.1 shows the various layers of the reflective system, in accordance with the general scheme sketched in Fig. 2.6. Functional objects model the functional and non reflective aspects of system objects, as exposed by the technological layer; for instance, a screen is an object where applications can display images. Reflective objects, on the other hand, model the non functional and QoS-related aspects of the system objects; for instance, a screen is modeled by its size, resolution and so on. The figure shows how the reflective mechanisms can be exploited in various ways, which will be discussed in the rest of this chapter. (Figure presented) Reflective applications rely on both domain-specific and reflective knowledge in order to provide adaptive services. Such applications exploit both functional and reflective objects. For instance, a reflective application (Reflective Application B in Fig. 4.1) can exploit both domain knowledge (e.g., user profiles) and reflective knowledge (e.g., QoS features of the devices exposed by the base reflective layer via Base R Objects) in order to provide the end user with an "optimal" service. The base reflective layer is discussed in Sect. 4.2. This approach allows sophisticated solutions to be devised, although they imply that software developers must be aware of the low-level QoS features of the underlying platform. To reduce this drawback, the extended reflective layer provides mechanisms for defining suitable QoS strategies that provide the visibility of extended R Objects. Such objects expose to the applications (Reflective Application A in Fig. 4.1) the QoS of the system objects at a higher level of abstraction. The extended reflective layer is discussed in Sect. 4.3. Reflective middleware is an intermediate tier that exploits reflective knowledge to provide applications with enhanced functional objects (i.e., functional objects with a better QoS). Non stationary distributed systems, i.e. systems where different parts exhibit great diversity in terms of message transfer delays, provide a difficult background for traditional two-tier architectures. In order to provide QoS, such as reliability and availability, for such systems we envisage the use of a three-tier architecture for service replication, where reflective middleware (i.e., an extended reflective layer) is interposed between the client layer and the end tier. The goal of this middle tier is to limit the scope of agreement protocols to well behaved parts of the system (where the middle and end tiers are located), thus relieving non reflective applications from the burden of such protocols. The three-tier scheme is represented on the right side of Fig. 4.1, where the middle tier exploits reflective knowledge to provide applications with the visibility of enhanced functional objects with improved QoS. This approach relieves the applications from the management of non functional issues, although the middle tier is bound to implement best effort policies that do not exploit domain specific knowledge. The three tier scheme for replication is discussed in Sect. 4.4. A simple example may help us to understand the two approaches. Assume that a back-end application generates a streaming video towards a front-end device. If the application itself is reflective, it can observe the QoS in detail via the appropriate R Objects and, possibly, the topology of the underlying communication subsystem as well. Therefore the application may either adapt itself to the available bandwidth (for instance, by tuning the compression rate) or control, whenever possible, the QoS of the communication subsystem (for instance, by choosing an alternate communication path). This allows the application to exploit domain knowledge (for instance, by choosing the communication path according to the requirements exposed by the user profile), at the price of a higher complexity. On the other hand, a reflective middleware layer can be interposed between the base reflective layer and the application. It would be in charge of exploiting some best-effort strategy (for instance, by choosing a communication path) in order to provide the application with a suitable QoS. The application would be simpler, as it would not have to manage reflective issues. The drawback is that the strategies implemented by the reflective middleware cannot exploit specific domain knowledge (for instance, the user profile). The proposed mechanisms can be exploited by higher-level software components, which are denoted in Fig. 4.1 as applications. In this perspective, the higher level components that implement the MAIS framework can be viewed as applications, even if they should more properly be viewed as middleware components. Section 4.2 recalls the concepts related to the computational reflection, and presents the base reflective layer. Section 4.3 describes the extended reflective layer. Section 4.4 discusses the three-tier model for replication. Finally, Section 4.5 sketches two application examples

Published
2006

32. Genome-wide Copy-number Alterations in Circulating Tumor DNA as a Novel Biomarker for Patients with High-grade Serous Ovarian Cancer.

Author

Paracchini L, Beltrame L, Grassi T, Inglesi A, Fruscio R, Landoni F, Ippolito D, Delle Marchette M, Paderno M, Adorni M, Jaconi M, Romualdi C, D'Incalci M, Siravegna G, and Marchini S

Subjects
Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Cystadenocarcinoma, Serous blood, Cystadenocarcinoma, Serous therapy, Diagnostic Imaging, Female, Genome-Wide Association Study, Humans, Liquid Biopsy methods, Middle Aged, Neoplasm Grading, Neoplasm Staging, Ovarian Neoplasms blood, Ovarian Neoplasms therapy, Sensitivity and Specificity, Treatment Outcome, Young Adult, Biomarkers, Tumor, Circulating Tumor DNA, Cystadenocarcinoma, Serous diagnosis, Cystadenocarcinoma, Serous genetics, DNA Copy Number Variations, Ovarian Neoplasms diagnosis, Ovarian Neoplasms genetics
Abstract

Purpose: High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor heterogeneity. Biomarkers serving to monitor drug response and detect disease recurrence are lacking, a fact which reflects an unmet clinical need., Experimental Design: A total of 185 plasma samples and 109 matched tumor biopsies were collected from 46 patients with HGS-EOC, and analyzed by shallow whole-genome sequencing (sWGS). The percentage of tumor fraction (TF) in the plasma was used to study the biological features of the disease at the time of diagnosis (T0) and correlated with patients' survival. Longitudinal analysis of TF was correlated with CA-125 levels and radiological images to monitor disease recurrence., Results: Gain in the clonal regions, 3q26.2 and 8q24.3 , was observed in the 87.8% and 78.05% of plasma samples, suggesting that plasma sWGS mirrors solid biopsies. At T0, multivariate analysis revealed that plasma TF levels were an independent prognostic marker of relapse ( P < 0.022). After platinum (Pt)-based treatment, circulating tumor DNA (ctDNA) analysis showed a change in the heterogeneous pattern of genomic amplification, including an increased frequency of amplification, compared with before Pt-based treatment in the 19p31.11 and 19q13.42 regions. TF in serially collected ctDNA samples outperformed CA-125 in anticipating clinical and radiological progression by 240 days (range, 37-491)., Conclusions: Our results support the notion that sWGS is an inexpensive and useful tool for the genomic analysis of ctDNA in patients with HGS-EOC to monitor disease evolution and to anticipate relapse better than serum CA-125, the routinely used clinical biomarker. See related commentary by Dhani, p. 2372 ., (©2020 American Association for Cancer Research.)

Published
2021
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33. Impact of invasive alien plants on native plant communities and Natura 2000 habitats: State of the art, gap analysis and perspectives in Italy.

Author

Lazzaro L, Bolpagni R, Buffa G, Gentili R, Lonati M, Stinca A, Acosta ATR, Adorni M, Aleffi M, Allegrezza M, Angiolini C, Assini S, Bagella S, Bonari G, Bovio M, Bracco F, Brundu G, Caccianiga M, Carnevali L, Di Cecco V, Ceschin S, Ciaschetti G, Cogoni A, Foggi B, Frattaroli AR, Genovesi P, Gigante D, Lucchese F, Mainetti A, Mariotti M, Minissale P, Paura B, Pellizzari M, Perrino EV, Pirone G, Poggio L, Poldini L, Poponessi S, Prisco I, Prosser F, Puglisi M, Rosati L, Selvaggi A, Sottovia L, Spampinato G, Stanisci A, Venanzoni R, Viciani D, Vidali M, Villani M, and Lastrucci L

Subjects
Biodiversity, Italy, Plants, Ecosystem, Introduced Species
Abstract

Invasive alien plants are a major threat to biodiversity and they contribute to the unfavourable conservation status of habitats of interest to the European Community. In order to favour implementation of European Union Regulation no. 1143/2014 on invasive alien species, the Italian Society of Vegetation Science carried out a large survey led by a task force of 49 contributors with expertise in vegetation across all the Italian administrative regions. The survey summed up the knowledge on impact mechanisms of invasive alien plants in Italy and their outcomes on plant communities and the EU habitats of Community Interest, in accordance with Directive no. 92/43/EEC. The survey covered 241 alien plant species reported as having deleterious ecological impacts. The data collected illustrate the current state of the art, highlight the main gaps in knowledge, and suggest topics to be further investigated. In particular, the survey underlined competition as being the main mechanism of ecological impact on plant communities and Natura 2000 habitats. Of the 241 species, only Ailanthus altissima was found to exert an ecological impact on plant communities and Natura 2000 habitats in all Italian regions; while a further 20 species impact up to ten out of the 20 Italian administrative regions. Our data indicate that 84 out of 132 Natura 2000 Habitats (64%) are subjected to some degree of impact by invasive alien plants. Freshwater habitats and natural and semi-natural grassland formations were impacted by the highest number of alien species, followed by coastal sand dunes and inland dunes, and forests. Although not exhaustive, this research is the first example of nationwide evaluation of the ecological impacts of invasive alien plants on plant communities and Natura 2000 Habitats., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Published
2020
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34. Detection of TP53 Clonal Variants in Papanicolaou Test Samples Collected up to 6 Years Prior to High-Grade Serous Epithelial Ovarian Cancer Diagnosis.

Author

Paracchini L, Pesenti C, Delle Marchette M, Beltrame L, Bianchi T, Grassi T, Buda A, Landoni F, Ceppi L, Bosetti C, Paderno M, Adorni M, Vicini D, Perego P, Leone BE, D'Incalci M, Marchini S, and Fruscio R

Subjects
Female, Humans, Mass Screening methods, Mass Screening statistics & numerical data, Middle Aged, Sensitivity and Specificity, Time Factors, Carcinoma, Ovarian Epithelial metabolism, Carcinoma, Ovarian Epithelial pathology, Clone Cells pathology, Cystadenocarcinoma, Serous metabolism, Cystadenocarcinoma, Serous pathology, Early Detection of Cancer methods, Ovarian Neoplasms metabolism, Ovarian Neoplasms pathology, Papanicolaou Test methods, Papanicolaou Test statistics & numerical data, Tumor Suppressor Protein p53 analysis
Abstract

Importance: The low 5-year survival rate of women with high-grade serous epithelial ovarian cancer (HGS-EOC) is related to its late diagnosis; thus, improvement in diagnosis constitutes a crucial step to increase the curability of this disease., Objective: To determine whether the presence of the clonal pathogenic TP53 variant detected in matched primary tumor biopsies can be identified in DNA purified from Papanicolaou test samples collected from women with HGS-EOC years before the diagnosis., Design, Setting, and Participants: This cohort study was conducted among a single-center cohort of women with histologically confirmed diagnosis of HGS-EOC recruited at San Gerardo Hospital, Monza, Italy, from October 15, 2015, to January 4, 2019. Serial dilutions of DNA derived from tumor samples and DNA extracted from healthy women's Papanicolaou test samples were analyzed to define the sensitivity and specificity of droplet digital polymerase chain reaction assays designed to detect the TP53 variants identified in tumors. All available brush-based Papanicolaou test slides performed up to 6 years before diagnosis were investigated at the Mario Negri Institute, Milano, Italy. Data were analyzed from October 2018 to December 2019., Main Outcomes and Measures: The presence of tumor pathogenic TP53 variants was assessed by the droplet digital polymerase chain reaction approach in DNA purified from Papanicolaou test samples obtained from the same patients before diagnosis during cervical cancer screenings., Results: Among 17 included patients (median [interquartile range] age at diagnosis, 60 [53-69] years), Papanicolaou tests withdrawn before diagnosis presented tumor-matched TP53 variants in 11 patients (64%). In 2 patients for whom longitudinal Papanicolaou tests were available, including 1 patient with Papanicolaou tests from 25 and 49 months before diagnosis and 1 patient with Papanicolaou tests from 27 and 68 months before diagnosis, the TP53 clonal variant was detected at all time points., Conclusions and Relevance: These findings suggest that noninvasive early molecular diagnosis of HGS-EOC is potentially achievable through detection of TP53 clonal variants in the DNA purified from Papanicolaou tests performed during cervical cancer screening.

Published
2020
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35. Impact of Bevacizumab-containing Primary Treatment on Outcome of Recurrent Ovarian Cancer: An Italian Study.

Author

Gadducci A, Cosio S, Lissoni AA, Zizioli V, Adorni M, Ferrero AM, Landoni F, and Sartori E

Subjects
Adult, Aged, Bevacizumab administration & dosage, Carboplatin, Carcinoma, Ovarian Epithelial mortality, Carcinoma, Ovarian Epithelial pathology, Cytoreduction Surgical Procedures, Female, Humans, Italy epidemiology, Middle Aged, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Ovarian Neoplasms mortality, Ovarian Neoplasms pathology, Paclitaxel, Retrospective Studies, Survival Rate, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Ovarian Epithelial drug therapy, Neoplasm Recurrence, Local drug therapy, Ovarian Neoplasms drug therapy
Abstract

Background/aim: The aim of the study was to assess the outcome of advanced ovarian cancer patients who i) underwent primary surgery followed by carboplatin/paclitaxel-based chemotherapy with or without bevacizumab, ii) were in complete response after chemotherapy, iii) and subsequently recurred., Patients and Methods: The hospital records of 138 complete responders after chemotherapy with (n=58) or without (n=80) bevacizumab were reviewed., Results: Both survival after recurrence and overall survival were related to age (≤61 vs. >61 years, p=0.002 and p=0.0001), performance status (0 vs. ≥1, p=0.002 and p=0.001), histotype (serous vs. non serous, p=0.005 and p=0.01), time to recurrence (≥12 vs. <12 months, p<0.0001 and p<0.0001) and treatment at recurrence (surgery plus chemotherapy vs. chemotherapy, p=0.01 and p=0.004), but not to first-line treatment., Conclusion: This investigation failed to detect a more aggressive behavior of recurrent ovarian cancer after bevacizumab-containing primary treatment., (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2020
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36. Aerobiological monitoring and mapping of Ambrosia plants in the province of Parma (northern Italy, southern Po valley), a useful tool for targeted preventive measures.

Author

Albertini R, Ugolotti M, Ghillani L, Adorni M, Vitali P, Signorelli C, and Pasquarella C

Subjects
Italy, Seasons, Time Factors, Air Pollutants, Ambrosia, Environmental Monitoring, Pollen, Rhinitis, Allergic, Seasonal prevention & control
Abstract

Background: Ambrosia is an annual anemophilous weed producing allergenic pollen affecting public health in European countries. In Italy, the most infested region is Lombardy where, in some areas, it is the major cause of hay fever. In the Parma district, until 2007, Ambrosia seemed to be very rare, despite an observed increase of Seasonal Pollen Index (SPI), of pollen peak value and of asthma among ragweed sensitized patients. The aims of this study were to calculate ragweed pollen season and trends from 1996 to 2015, to assess the relationships between pollen season characteristics and selected meteorological data, to map plants in the territory and to evaluate the presence of beetle Ophraella communa (Ophraella), known as an eater of Ambrosia leaves., Methods: The following pollination parameters: start, end, duration, peak concentration date, peak values, SPI and the following climatic parameters: temperature, relative humidity, rainfall, were analyzed. The ragweed plants sites were mapped and the presence of Ophraella was assessed during naturalistic activities., Results: Significant SPI and pollen peak value increase until 2011 were observed, but recently, 2012-2015 vs 2009-2011, a strong reduction (about 50%) of these parameters was observed. The spring average air temperature increased significantly. The results of the correlation analysis showed Ambrosia season characteristics significantly related. We identified the sites source of Ambrosia, even downtown at the confluence between Parma and Baganza rivers. Ophraella was observed for the first time in 2014., Conclusions: The results showed the spread of ragweed plants over the territory and the risk of allergy increase that ragweed could cause. It remains to evaluate the role of the Ophraella in the reduction of Ambrosia pollen concentration. It is important to consider the potential risk Ophraella may represent for sunflower and other taxonomically related crop plants and other native and exotic species. The lack of initiatives by the Health Authorities to prevent and to contrast the spread of Ambrosia in the Parma area could cause public health consequences and an increase in health expenditures.

Published
2017
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