Search

Your search keyword '"Albrecht-Schgoer, Karin"' showing total 14 results
Start Over Author "Albrecht-Schgoer, Karin" Search Limiters Full Text
14 results on '"Albrecht-Schgoer, Karin"'

5. Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

Author

Peer, Sebastian, Cappellano, Giuseppe, Hermann-Kleiter, Natascha, Albrecht-Schgoer, Karin, Hinterleitner, Reinhard, Baier, Gottfried, and Gruber, Thomas

Subjects
CD4-Positive T-Lymphocytes, Mice, Knockout, Encephalomyelitis, Autoimmune, Experimental, Immunology, experimental autoimmune encephalomyelitis, Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF, Autoimmunity, adaptive immunity, multiple sclerosis, Mice, Inbred C57BL, Gene Expression Regulation, Cbl-b, Animals, Interleukin-3, Proto-Oncogene Proteins c-cbl, Promoter Regions, Genetic, Original Research, Adaptor Proteins, Signal Transducing
Abstract

Genome-wide association studies as well as lymphatic expression analyses have linked both Cbl-b and GM-CSF to human multiple sclerosis as well as other autoimmune diseases. Both Cbl-b and GM-CSF have been shown to play a prominent role in the development of murine encephalomyelitis; however, no functional connection between the two has yet been established. In this study, we show that Cblb knockout mice demonstrated significantly exacerbated severity of experimental autoimmune encephalomyelitis (EAE), augmented T cell infiltration into the central nervous system (CNS) and strongly increased production of GM-CSF in T cells in vitro and in vivo.GM-CSF neutralization demonstrated that the increased susceptibility of Cblb−/− mice to EAE was dependent on GM-CSF. Mechanistically, p50 binding to the GM-CSF promoter and the IL-3/GM-CSF enhancer element “CNSa” was strongly increased in nuclear extracts from Cbl-b-deficient T cells. This study suggests that Cbl-b limits autoimmunity by preventing the pathogenic effects of GM-CSF overproduction in T cells.

Published
2018

6. Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice

Author

Pfeifhofer-Obermair, Christa, Albrecht-Schgoer, Karin, Peer, Sebastian, Nairz, Manfred, Siegmund, Kerstin, Klepsch, Victoria, Haschka, David, Thuille, Nikolaus, Hermann-Kleiter, Natascha, Gruber, Thomas, Weiss, Günter, and Baier, Gottfried

Subjects
Salmonella typhimurium, Innate immunity, Research, Macrophages, Cell Biology, Macrophage Activation, Interleukin-10, Isoenzymes, Mice, Inbred C57BL, Interferon-gamma, Mice, Protein Kinase C-theta, Macrophage polarization, IL-10, Salmonella Infections, Animals, Protein kinase C theta, Interleukin-4, Molecular Biology, Cells, Cultured, Protein Kinase C
Abstract

Background The serine/threonine protein kinase C (PKC) theta has been firmly implicated in T cell-mediated immunity. Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta−/−) mice in order to investigate if PKCtheta plays a role in macrophage-mediated immune responses during bacterial infections. Results Our results demonstrate that PKCtheta plays an important role in host defense against the Gram-negative, intracellular bacterium Salmonella typhimurium, as reflected both by markedly decreased survival and a significantly enhanced number of bacteria in spleen and liver of PKCtheta−/− mice, when compared to wild-type mice. Of note, albeit macrophages do not express detectable PKCtheta, PKCtheta mRNA expression was found to be profoundly upregulated during the first hours of lipopolysaccharide (LPS)/interferon-gamma (IFNgamma)-, but not IL-4-mediated cell polarization conditions in vitro. Mechanistically, despite expressing normal levels of classically activated macrophage (CAM) markers, PKCtheta-deficient CAMs expressed significantly higher levels of the anti-inflammatory cytokine IL-10 in vivo and in vitro when challenged with S. typhimurium or LPS/IFNgamma. Neutralization of IL-10 recovered immune control to S. typhimurium infection in PKCtheta-deficient macrophages. Conclusions Taken together, our data provide genetic evidence that PKCtheta promotes a potent pro-inflammatory CAM phenotype that is instrumental to mounting protective anti-bacterial immunity. Mechanistically, PKCtheta exerts a host-protective role against S. typhimurium infection, and acts as an essential link between TLR4/IFNgammaR signaling and selective suppression of the anti-inflammatory cytokine IL-10 at the onset of CAM differentiation in the course of a bacterial infection.

Published
2016

7. Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Author

Holfeld, Johannes, primary, Tepeköylü, Can, additional, Reissig, Christin, additional, Lobenwein, Daniela, additional, Scheller, Bertram, additional, Kirchmair, Elke, additional, Kozaryn, Radoslaw, additional, Albrecht-Schgoer, Karin, additional, Krapf, Christoph, additional, Zins, Karin, additional, Urbschat, Anja, additional, Zacharowski, Kai, additional, Grimm, Michael, additional, Kirchmair, Rudolf, additional, and Paulus, Patrick, additional

Published
2015
Full Text
View/download PDF

8. Further Evaluation of Pro-Atherogenic and Anti-Angiogenic Effects of Nilotinib in Mice and in Patients with Ph-Chromosome+ CML

Author

Hadzijusufovic, Emir, primary, Albrecht-Schgoer, Karin, additional, Huber, Kilian, additional, Grebien, Florian, additional, Eisenwort, Gregor, additional, Schgoer, Wilfried, additional, Kaun, Christoph, additional, Herndlhofer, Susanne, additional, Theurl, Markus, additional, Cerny-Reiterer, Sabine, additional, Hoermann, Gregor, additional, Sperr, Wolfgang R, additional, Rix, Uwe, additional, Sadovnik, Irina, additional, Jilma, Bernd, additional, Schernthaner, Gerit Holger, additional, Wojta, Johann, additional, Wolf, Dominik, additional, Superti-Furga, Giulio, additional, Kirchmair, Rudolf, additional, and Valent, Peter, additional

Published
2014
Full Text
View/download PDF

9. Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E−/− mice without influencing systemic atherosclerosis

Author

Theurl, Markus, primary, Schgoer, Wilfried, additional, Albrecht-Schgoer, Karin, additional, Lener, Daniela, additional, Wolf, Dominik, additional, Wolf, Maria, additional, Demetz, Egon, additional, Tymoszuk, Piotr, additional, Tancevski, Ivan, additional, Fischer-Colbrie, Reiner, additional, Franz, Wolfgang-Michael, additional, Marschang, Peter, additional, and Kirchmair, Rudolf, additional

Published
2014
Full Text
View/download PDF

10. Abstract 18112: Low-Energy Shock Wave Treatment Induces Angiogenesis in Ischemic Muscle by Stimulation of Toll-Like Receptor 3 Signaling

Author

Holfeld, Johannes, primary, Tepeköylü, Can, additional, Kozaryn, Radoslaw, additional, Albrecht-Schgoer, Karin, additional, Krapf, Christoph, additional, Kirchmair, Rudolf, additional, Bernhard, David, additional, Zacharowski, Kai, additional, Urbschat, Anja, additional, Grimm, Michael, additional, and Paulus, Patrick, additional

Published
2013
Full Text
View/download PDF

11. Nilotinib Exerts Direct Pro-Atherogenic and Anti-Angiogenic Effects On Vascular Endothelial Cells: A Potential Explanation For Drug-Induced Vasculopathy In CML

Author

Emir, Hadzijusufovic, primary, Albrecht-Schgoer, Karin, additional, Huber, Kilian, additional, Grebien, Florian, additional, Eisenwort, Gregor, additional, Schgoer, Wilfried, additional, Kaun, Christoph, additional, Herndlhofer, Susanne, additional, Theurl, Markus, additional, Cerny-Reiterer, Sabine, additional, Hoermann, Gregor, additional, Sperr, Wolfgang R, additional, Uwe, Rix, additional, Wojta, Johann, additional, Wolf, Dominik, additional, Superti-Furga, Giulio, additional, Kirchmair, Rudolf, additional, and Valent, Peter, additional

Published
2013
Full Text
View/download PDF

14. The Angiogenic Factor Secretoneurin Induces Coronary Angiogenesis in a Model of Myocardial Infarction by Stimulation of Vascular Endothelial Growth Factor Signaling in Endothelial Cells

Author

Albrecht-Schgoer, Karin, primary, Schgoer, Wilfried, additional, Holfeld, Johannes, additional, Theurl, Markus, additional, Wiedemann, Dominik, additional, Steger, Christina, additional, Gupta, Rajesh, additional, Semsroth, Severin, additional, Fischer-Colbrie, Reiner, additional, Beer, Arno G.E., additional, Stanzl, Ursula, additional, Huber, Eva, additional, Misener, Sol, additional, Dejaco, Daniel, additional, Kishore, Raj, additional, Pachinger, Otmar, additional, Grimm, Michael, additional, Bonaros, Nikolaos, additional, and Kirchmair, Rudolf, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results