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6 results on '"Alexiou, Aikaterina"'

1. Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Published
2022
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2. An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium

Author

Worm, Margitta, primary, Alexiou, Aikaterina, additional, Höfer, Veronika, additional, Birkner, Till, additional, Jeanrenaud, Alexander C. S. N., additional, Fauchère, Florent, additional, Pazur, Kristijan, additional, Steinert, Carolin, additional, Arnau‐Soler, Aleix, additional, Banerjee, Priyanka, additional, Diefenbach, Andreas, additional, Dobbertin‐Welsch, Josefine, additional, Dölle‐Bierke, Sabine, additional, Francuzik, Wojciech, additional, Ghauri, Ahla, additional, Heller, Stephanie, additional, Kalb, Birgit, additional, Löber, Ulrike, additional, Marenholz, Ingo, additional, Markó, Lajos, additional, Scheffel, Jörg, additional, Potapenko, Olena, additional, Roll, Stephanie, additional, Lau, Susanne, additional, Lee, Young‐Ae, additional, Braun, Julian, additional, Thiel, Andreas, additional, Babina, Magda, additional, Altrichter, Sabine, additional, Forslund, Sofia Kirke, additional, and Beyer, Kirsten, additional

Published
2022
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3. An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium

Author

Worm, Margitta M., Alexiou, Aikaterina, Höfer, Veronika, Birkner, Till, Jeanrenaud, Alexander C.S.N., Fauchère, Florent, Pažur, Kristijan, Steinert, Carolin, Arnau-Soler, Aleix, Banerjee, Priyanka, Diefenbach, Andreas, Dobbertin-Welsch, Josefine, Dölle-Bierke, Sabine, Francuzik, W., Ghauri, Ahla, Heller, Stephanie, Kalb, Birgit, Löber, Ulrike, Marenholz, Ingo, Markó, Lajos, Scheffel, Jörg, Potapenko, Olena, Roll, Stephanie, Lau, Susanne, Lee, Young-ae, Braun, Julian, Thiel, Andreas, Babina, Magda, Altrichter, Sabine, Forslund, Sofia Kirke, Beyer, Kirsten, and Publica

Subjects
food allergy, epigenetics, Cardiovascular and Metabolic Diseases, biomarker, microbiome, peanut allergy
Abstract

Background: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. Methods: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.

Published
2022

4. Additional file 3 of Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Abstract

Additional file 3. Consent Form (in German).

Published
2022
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5. Additional file 1 of Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Abstract

Additional file 1. The SPIRIT Checklist.

Published
2022
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