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3. Gate-Tunable Transmon Using Selective-Area-Grown Superconductor-Semiconductor Hybrid Structures on Silicon

Author

Hertel, A., Eichinger, M., Andersen, L. O., van Zanten, D. M. T., Kallatt, S., Scarlino, P., Kringhøj, A., Chavez-Garcia, J. M., Gardner, G. C., Gronin, S., Manfra, M. J., Gyenis, A., Kjaergaard, M., Marcus, C. M., and Petersson, K. D.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We present a gate-voltage tunable transmon qubit (gatemon) based on planar InAs nanowires that are selectively grown on a high resistivity silicon substrate using III-V buffer layers. We show that low loss superconducting resonators with an internal quality of $2\times 10^5$ can readily be realized using these substrates after the removal of buffer layers. We demonstrate coherent control and readout of a gatemon device with a relaxation time, $T_{1}\approx 700\,\mathrm{ns}$, and dephasing times, $T_2^{\ast}\approx 20\,\mathrm{ns}$ and $T_{\mathrm{2,echo}} \approx 1.3\,\mathrm{\mu s}$. Further, we infer a high junction transparency of $0.4 - 0.9$ from an analysis of the qubit anharmonicity.

Published
2022
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4. Electrical Properties of Selective-Area-Grown Superconductor-Semiconductor Hybrid Structures on Silicon

Author

Hertel, A., Andersen, L. O., van Zanten, D. M. T., Eichinger, M., Scarlino, P., Yadav, S., Karthik, J., Gronin, S., Gardner, G. C., Manfra, M. J., Marcus, C. M., and Petersson, K. D.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Superconductivity
Abstract

We present a superconductor-semiconductor material system that is both scalable and monolithically integrated on a silicon substrate. It uses selective area growth of Al-InAs hybrid structures on a planar III-V buffer layer, grown directly on a high resistivity silicon substrate. We characterized the electrical properties of this material system at millikelvin temperatures and observed a high average field-effect mobility of $\mu \approx 3200\,\mathrm{cm^2/Vs}$ for the InAs channel, and a hard induced superconducting gap. Josephson junctions exhibited a high interface transmission, $\mathcal{T} \approx 0.75 $, gate voltage tunable switching current with a product of critical current and normal state resistance, $I_{\mathrm{C}}R_{\mathrm{N}} \approx 83\,\mathrm{\mu V}$, and signatures of multiple Andreev reflections. These results pave the way for scalable and high coherent gate voltage tunable transmon devices and other superconductor-semiconductor hybrids fabricated directly on silicon.

Published
2021
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7. Absorption and luminescence spectroscopy of mass-selected Flavin Adenine Dinucleotide mono-anions

Author

Giacomozzi, L., Kjær, C., Knudsen, J. Langeland, Andersen, L. H., Nielsen, S. Brøndsted, and Stockett, M. H.

Subjects
Physics - Chemical Physics
Abstract

We report the absorption profile of isolated Flavin Adenine Dinucleotide (FAD) mono-anions recorded using Photo-Induced Dissociation action spectroscopy. In this charge state, one of the phosphoric acid groups is deprotonated and the chromophore itself is in its neutral oxidized state. These measurements cover the first four optical transitions of FAD with excitation energies from 2.3 to 6.0~eV (210--550~nm). The $S_0\rightarrow S_2$ transition is strongly blue-shifted relative to aqueous solution, supporting the view that this transition has significant charge-transfer character. The remaining bands are close to their solution-phase positions. This confirms that the large discrepancy between quantum chemical calculations of vertical transition energies and solution-phase band maxima can not be explained by solvent effects. We also report the luminescence spectrum of FAD mono-anions \textit{in vacuo}. The gas-phase Stokes shift for $S_1$ is 3000~cm$^{-1}$, which is considerably larger than any previously reported for other molecular ions and consistent with a significant displacement of the ground and excited state potential energy surfaces. Consideration of vibronic structure is thus essential for simulating the absorption and luminescence spectra of flavins.

Published
2018
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10. Photo-stability of super-hydrogenated PAHs determined by action spectroscopy experiments

Author

Wolf, M., Kiefer, H. V., Langeland, J., Andersen, L. H., Zettergren, H., Schmidt, H. T., Cederquist, H., and Stockett, M. H.

Subjects
Astrophysics - Astrophysics of Galaxies, Physics - Atomic and Molecular Clusters
Abstract

We have investigated the photo-stability of pristine and super-hydrogenated pyrene cations C$_{16}$H$_{10+m}^+, m = 0,6, \mathrm{\ or\ } 16$) by means of gas-phase action spectroscopy. Optical absorption spectra and photo-induced dissociation mass spectra are presented. By measuring the yield of mass-selected photo-fragment ions as a function of laser pulse intensity, the number of photons (and hence the energy) needed for fragmentation of the carbon backbone was determined. Backbone fragmentation of pristine pyrene ions (C$_{16}$H$_{10}^+$) requires absorption of three photons of energy just below 3 eV, whereas super-hydrogenated hexahydropyrene (C$_{16}$H$_{16}^+$) must absorb two such photons and fully hydrogenated hexadecahydropyrene (C$_{16}$H$_{26}^+$) only a single photon. These results are consistent with previously reported dissociation energies for these ions. Our experiments clearly demonstrate that the increased heat capacity from the additional hydrogen atoms does not compensate for the weakening of the carbon backbone when pyrene is hydrogenated. In photodissociation regions, super-hydrogenated Polycyclic Aromatic Hydrocarbons (PAHs) have been proposed to serve as catalysts for H$_2$-formation. Our results indicate that carbon backbone fragmentation may be a serious competitor to H$_2$-formation at least for small hydrogenated PAHs like pyrene., Comment: 6 pages, 4 figures, accepted in The Astrophysical Journal

Published
2016
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11. Anisotropy study of multiferroicity in the pyroxene NaFeGe$_2$O$_6$

Author

Ackermann, M., Andersen, L., Lorenz, T., Bohaty, L., and Becker, P.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We present a study of the anisotropy of the dielectric, magnetic and magnetoelastic properties of the multiferroic clinopyroxene NaFeGe$_2$O$_6$. Pyroelectric currents, dielectric constants and magnetic susceptibilities as well as the thermal expansion and the magnetostriction were examined on large synthetic single crystals of NaFeGe$_2$O$_6$. The spontaneous electric polarization detected below $T_{\rm C}\simeq 11.6$ K in an antiferromagnetically ordered state ($T_{\rm N}\simeq 13$ K) is mainly lying within the $ac$ plane with a small component along $b$, indicating a triclinic symmetry of the multiferroic phase of NaFeGe$_2$O$_6$. The electric polarization can be strongly modified by applying magnetic fields along different directions. We derive detailed magnetic-field versus temperature phase diagrams and identify three multiferroic low-temperature phases, which are separated by a non-ferroelectric, antiferromagnetically ordered state from the paramagnetic high-temperature phase., Comment: 14 pages, 8 figures. (minor modifications and corrections of the text)

Published
2014
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12. A just world on a safe planet: a Lancet Planetary Health–Earth Commission report on Earth-system boundaries, translations, and transformations

Author

Gupta, J. Bai, X. Liverman, D. M. Rockström, J. Qin, D. Stewart-Koster, B. Rocha, J. C. Jacobson, L. Abrams, J. F. Andersen, L. S. Armstrong McKay, D. I. Bala, G. Bunn, S. E. Ciobanu, D. DeClerck, F. Ebi, K. L. Gifford, L. Gordon, C. Hasan, S. Kanie, N. Lenton, T. M. Loriani, S. Mohamed, A. Nakicenovic, N. Obura, D. Ospina, D. Prodani, K. Rammelt, C. Sakschewski, B. Scholtens, J. Tharammal, T. van Vuuren, D. Verburg, P. H. Winkelmann, R. Zimm, C. Bennett, E. Bjørn, A. Bringezu, S. Broadgate, W. J. Bulkeley, H. Crona, B. Green, P. A. Hoff, H. Huang, L. Hurlbert, M. Inoue, C. Y. A. Kılkış, Ş Lade, S. J. Liu, J. Nadeem, I. Ndehedehe, C. Okereke, C. Otto, I. M. Pedde, S. Pereira, L. Schulte-Uebbing, L. Tàbara, J. D. de Vries, W. Whiteman, G. Xiao, C. Xu, X. Zafra-Calvo, N. Zhang, X. Fezzigna, P. Gentile, G. and Gupta, J. Bai, X. Liverman, D. M. Rockström, J. Qin, D. Stewart-Koster, B. Rocha, J. C. Jacobson, L. Abrams, J. F. Andersen, L. S. Armstrong McKay, D. I. Bala, G. Bunn, S. E. Ciobanu, D. DeClerck, F. Ebi, K. L. Gifford, L. Gordon, C. Hasan, S. Kanie, N. Lenton, T. M. Loriani, S. Mohamed, A. Nakicenovic, N. Obura, D. Ospina, D. Prodani, K. Rammelt, C. Sakschewski, B. Scholtens, J. Tharammal, T. van Vuuren, D. Verburg, P. H. Winkelmann, R. Zimm, C. Bennett, E. Bjørn, A. Bringezu, S. Broadgate, W. J. Bulkeley, H. Crona, B. Green, P. A. Hoff, H. Huang, L. Hurlbert, M. Inoue, C. Y. A. Kılkış, Ş Lade, S. J. Liu, J. Nadeem, I. Ndehedehe, C. Okereke, C. Otto, I. M. Pedde, S. Pereira, L. Schulte-Uebbing, L. Tàbara, J. D. de Vries, W. Whiteman, G. Xiao, C. Xu, X. Zafra-Calvo, N. Zhang, X. Fezzigna, P. Gentile, G.

Abstract

The health of the planet and its people are at risk. The deterioration of the global commons—ie, the natural systems that support life on Earth—is exacerbating energy, food, and water insecurity, and increasing the risk of disease, disaster, displacement, and conflict. In this Commission, we quantify safe and just Earth-system boundaries (ESBs) and assess minimum access to natural resources required for human dignity and to enable escape from poverty. Collectively, these describe a safe and just corridor that is essential to ensuring sustainable and resilient human and planetary health and thriving in the Anthropocene. We then discuss the need for translation of ESBs across scales to inform science-based targets for action by key actors (and the challenges in doing so), and conclude by identifying the system transformations necessary to bring about a safe and just future. Our concept of the safe and just corridor advances research on planetary boundaries and the justice and Earth-system aspects of the Sustainable Development Goals. We define safe as ensuring the biophysical stability of the Earth system, and our justice principles include minimising harm, meeting minimum access needs, and redistributing resources and responsibilities to enhance human health and wellbeing. The ceiling of the safe and just corridor is defined by the more stringent of the safe and just ESBs to minimise significant harm and ensure Earth-system stability. The base of the corridor is defined by the impacts of minimum global access to food, water, energy, and infrastructure for the global population, in the domains of the variables for which we defined the ESBs. Living within the corridor is necessary, because exceeding the ESBs and not meeting basic needs threatens human health and life on Earth. However, simply staying within the corridor does not guarantee justice because within the corridor resources can also be inequitably distributed, aggravating human health and causing environmenta

Published
2024
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13. Living within the safe and just Earth system boundaries for blue water

Author

Stewart-Koster, B. Bunn, S. E. Green, P. Ndehedehe, C. Andersen, L. S. Armstrong McKay, D. I. Bai, X. DeClerck, F. Ebi, K. L. Gordon, C. Gupta, J. Hasan, S. Jacobson, L. Lade, S. J. Liverman, D. Loriani, S. Mohamed, A. Nakicenovic, N. Obura, D. Qin, D. Rammelt, C. Rocha, J. C. Rockström, J. Verburg, P. H. Zimm, C. and Stewart-Koster, B. Bunn, S. E. Green, P. Ndehedehe, C. Andersen, L. S. Armstrong McKay, D. I. Bai, X. DeClerck, F. Ebi, K. L. Gordon, C. Gupta, J. Hasan, S. Jacobson, L. Lade, S. J. Liverman, D. Loriani, S. Mohamed, A. Nakicenovic, N. Obura, D. Qin, D. Rammelt, C. Rocha, J. C. Rockström, J. Verburg, P. H. Zimm, C.

Abstract

Safe and just Earth system boundaries (ESBs) for surface water and groundwater (blue water) have been defined for sustainable water management in the Anthropocene. Here we assessed whether minimum human needs could be met with surface water from within individual river basins alone and, where this is not possible, quantified how much groundwater would be required. Approximately 2.6 billion people live in river basins where groundwater is needed because they are already outside the surface water ESB or have insufficient surface water to meet human needs and the ESB. Approximately 1.4 billion people live in river basins where demand-side transformations would be required as they either exceed the surface water ESB or face a decline in groundwater recharge and cannot meet minimum needs within the ESB. A further 1.5 billion people live in river basins outside the ESB, with insufficient surface water to meet minimum needs, requiring both supply- and demand-side transformations. These results highlight the challenges and opportunities of meeting even basic human access needs to water and protecting aquatic ecosystems.

Published
2024
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14. The role of citizen science in addressing grand challenges in food and agriculture research

Author

Ryan, S. F., Adamson, N. L., Aktipis, A., Andersen, L. K., Austin, R., Barnes, L., Beasley, M. R., Bedell, K. D., Briggs, S., Chapman, B., Cooper, C. B., Corn, J. O., Creamer, N. G., Delborne, J. A., Domenico, P., Driscoll, E., Goodwin, J., Hjarding, A., Hulbert, J. M., Isard, S., Just, M. G., Gupta, K. Kar, López-Uribe, M. M., O’Sullivan, J., Landis, E. A., Madden, A. A., McKenney, E. A., Nichols, L. M., Reading, B. J., Russell, S., Sengupta, N., Shapiro, L. R., Shell, L. K., Sheard, J. K., Shoemaker, D. D., Sorger, D. M., Starling, C., Thakur, S., Vatsavai, R. R., Weinstein, M., Winfrey, P., and Dunn, R. R.

Published
2018

19. During heat stress in Myxococcus xanthus, the CdbS PilZ domain protein, in concert with two PilZ-DnaK chaperones, perturbs chromosome organization and accelerates cell death

Author

Seidel, M., Skotnicka, D., Glatter, T., https://orcid.org/0000-0001-8716-8516, Søgaard-Andersen, L., and https://orcid.org/0000-0002-0674-0013

Abstract

Author summary The nucleotide-based second messenger c-di-GMP in bacteria controls numerous processes in response to environmental or cellular cues. Typically, these processes are related to lifestyle transitions between motile and sessile behaviors. However, c-di-GMP also regulates other processes. In Myxococcus xanthus, CdbA is a DNA-binding and nucleoid-associated protein that helps to organize the large chromosome. CdbA binds c-di-GMP and DNA in a mutually exclusive manner. While other nucleoid-associated proteins are not essential, CdbA is essential. Here, we show that the crucial function of CdbA is to maintain the level of the c-di-GMP-binding PilZ-domain protein CdbS appropriately low. The CdbS level is not only increased upon depletion of CdbA but also in response to heat stress. Under both conditions, the increased CdbS level perturbs chromosome organization and ultimately causes cell death. The CdbA/CdbS system represents a unique system that contributes to regulated cell death in M. xanthus and suggests a link between c-di-GMP signaling and regulated cell death.

Published
2023

20. COVIDiSTRESS diverse dataset on psychological and behavioural outcomes one year into the COVID-19 pandemic

Author

Blackburn, A, Vestergren, S, Tran, T, Stockli, S, Griffin, S, Ntontis, E, Jeftic, A, Chrona, S, Ikizer, G, Han, H, Milfont, T, Parry, D, Byrne, G, Gomez-Lopez, M, Acosta, A, Kowal, M, De Leon, G, Gallegos, A, Perez, M, Abdelrahman, M, Ahern, E, Yar, A, Ahmed, O, Alami, N, Amin, R, Andersen, L, Araujo, B, Asongu, N, Bartsch, F, Bavolar, J, Bhatta, K, Bircan, T, Bita, S, Bombuwala, H, Brik, T, Cakal, H, Caniels, M, Carballo, M, Carvalho, N, Cely, L, Chang, S, Chayinska, M, Chen, F, Ch'Ng, B, Chukwuorji, J, Costa, A, Dalizu, V, Deschrijver, E, Dilekler Aldemir, I, Doherty, A, Doller, R, Dubrov, D, Elegbede, S, Elizalde, J, Ermagan-Caglar, E, Fernandez-Morales, R, Garcia-Castro, J, Gelpi, R, Ghafori, S, Goldberg, X, Gonzalez-Uribe, C, Alpizar-Rojas, H, Haugestad, C, Higuera, D, Hoorelbeke, K, Hristova, E, Hubena, B, Huq, H, Ihaya, K, Jayathilake, G, Jen, E, Jinadasa, A, Joksimovic, J, Kacmar, P, Kadreva, V, Kalinova, K, Kandeel, H, Kellezi, B, Khan, S, Kontogianni, M, Koszalkowska, K, Krzysztof, H, Lacko, D, Landa-Blanco, M, Lee, Y, Lieberoth, A, Lins, S, Liutsko, L, Londero-Santos, A, Mauritsen, A, Maegli, M, Magidie, P, Maharjan, R, Makaveeva, T, Makhubela, M, Malagon, M, Malykh, S, Mamede, S, Mandillah, S, Mansoor, M, Mari, S, Marin-Lopez, I, Marot, T, Martinez, S, Mauka, J, Moss, S, Mushtaq, A, Musliu, A, Mususa, D, Najmussaqib, A, Nasheeda, A, Nasr, R, Machado, N, Natividade, J, Ngowi, H, Nyarangi, C, Ogunbode, C, Onyutha, C, Padmakumar, K, Paniagua, W, Pena, M, Pirko, M, Portela, M, Pouretemad, H, Rachev, N, Ratodi, M, Reifler, J, Sadeghi, S, Sahayanathan, H, Sanchez, E, Sandbakken, E, Sandesh, D, Sanjesh, S, Schrotter, J, Shanthakumar, S, Sikka, P, Slaveykova, K, Studzinska, A, Subandi, F, Subedi, N, Sullivan, G, Tag, B, Delphine, T, Tamayo-Agudelo, W, Travaglino, G, Tuominen, J, Turk-Kurtca, T, Vakai, M, Volkodav, T, Wang, A, Williams, A, Wu, C, Yamada, Y, Yaneva, T, Yanez, N, Yeh, Y, Zoletic, E, Blackburn A. M., Vestergren S., Tran T. P., Stockli S., Griffin S. M., Ntontis E., Jeftic A., Chrona S., Ikizer G., Han H., Milfont T. L., Parry D., Byrne G., Gomez-Lopez M., Acosta A., Kowal M., De Leon G., Gallegos A., Perez M., Abdelrahman M., Ahern E., Yar A. W. A., Ahmed O., Alami N. H., Amin R., Andersen L. E., Araujo B. O., Asongu N. A., Bartsch F., Bavolar J., Bhatta K. R., Bircan T., Bita S., Bombuwala H., Brik T., Cakal H., Caniels M., Carballo M., Carvalho N. M., Cely L., Chang S., Chayinska M., Chen F. -Y., Ch'ng B., Chukwuorji J. B. C., Costa A. R., Dalizu V. L., Deschrijver E., Dilekler Aldemir I., Doherty A. M., Doller R., Dubrov D., Elegbede S., Elizalde J., Ermagan-Caglar E., Fernandez-Morales R., Garcia-Castro J. D., Gelpi R., Ghafori S., Goldberg X., Gonzalez-Uribe C., Alpizar-Rojas H., Haugestad C. A. P., Higuera D., Hoorelbeke K., Hristova E., Hubena B., Huq H., Ihaya K., Jayathilake G., Jen E., Jinadasa A., Joksimovic J., Kacmar P., Kadreva V., Kalinova K., Kandeel H. A. A., Kellezi B., Khan S., Kontogianni M., Koszalkowska K., Krzysztof H., Lacko D., Landa-Blanco M., Lee Y., Lieberoth A., Lins S., Liutsko L., Londero-Santos A., Mauritsen A. L., Maegli M. A., Magidie P., Maharjan R., Makaveeva T., Makhubela M., Malagon M. G., Malykh S., Mamede S., Mandillah S., Mansoor M. S., Mari S., Marin-Lopez I., Marot T. A., Martinez S., Mauka J., Moss S. M., Mushtaq A., Musliu A., Mususa D., Najmussaqib A., Nasheeda A., Nasr R., Machado N. N., Natividade J. C., Ngowi H. P., Nyarangi C., Ogunbode C., Onyutha C., Padmakumar K., Paniagua W., Pena M. C., Pirko M., Portela M., Pouretemad H., Rachev N., Ratodi M., Reifler J., Sadeghi S., Sahayanathan H. S., Sanchez E., Sandbakken E. M., Sandesh D., Sanjesh S., Schrotter J., Shanthakumar S., Sikka P., Slaveykova K., Studzinska A., Subandi F. D., Subedi N., Sullivan G. B., Tag B., Delphine T. E. A., Tamayo-Agudelo W., Travaglino G. A., Tuominen J., Turk-Kurtca T., Vakai M., Volkodav T., Wang A. H. -E. W., Williams A., Wu C., Yamada Y., Yaneva T., Yanez N., Yeh Y. -Y., Zoletic E., Blackburn, A, Vestergren, S, Tran, T, Stockli, S, Griffin, S, Ntontis, E, Jeftic, A, Chrona, S, Ikizer, G, Han, H, Milfont, T, Parry, D, Byrne, G, Gomez-Lopez, M, Acosta, A, Kowal, M, De Leon, G, Gallegos, A, Perez, M, Abdelrahman, M, Ahern, E, Yar, A, Ahmed, O, Alami, N, Amin, R, Andersen, L, Araujo, B, Asongu, N, Bartsch, F, Bavolar, J, Bhatta, K, Bircan, T, Bita, S, Bombuwala, H, Brik, T, Cakal, H, Caniels, M, Carballo, M, Carvalho, N, Cely, L, Chang, S, Chayinska, M, Chen, F, Ch'Ng, B, Chukwuorji, J, Costa, A, Dalizu, V, Deschrijver, E, Dilekler Aldemir, I, Doherty, A, Doller, R, Dubrov, D, Elegbede, S, Elizalde, J, Ermagan-Caglar, E, Fernandez-Morales, R, Garcia-Castro, J, Gelpi, R, Ghafori, S, Goldberg, X, Gonzalez-Uribe, C, Alpizar-Rojas, H, Haugestad, C, Higuera, D, Hoorelbeke, K, Hristova, E, Hubena, B, Huq, H, Ihaya, K, Jayathilake, G, Jen, E, Jinadasa, A, Joksimovic, J, Kacmar, P, Kadreva, V, Kalinova, K, Kandeel, H, Kellezi, B, Khan, S, Kontogianni, M, Koszalkowska, K, Krzysztof, H, Lacko, D, Landa-Blanco, M, Lee, Y, Lieberoth, A, Lins, S, Liutsko, L, Londero-Santos, A, Mauritsen, A, Maegli, M, Magidie, P, Maharjan, R, Makaveeva, T, Makhubela, M, Malagon, M, Malykh, S, Mamede, S, Mandillah, S, Mansoor, M, Mari, S, Marin-Lopez, I, Marot, T, Martinez, S, Mauka, J, Moss, S, Mushtaq, A, Musliu, A, Mususa, D, Najmussaqib, A, Nasheeda, A, Nasr, R, Machado, N, Natividade, J, Ngowi, H, Nyarangi, C, Ogunbode, C, Onyutha, C, Padmakumar, K, Paniagua, W, Pena, M, Pirko, M, Portela, M, Pouretemad, H, Rachev, N, Ratodi, M, Reifler, J, Sadeghi, S, Sahayanathan, H, Sanchez, E, Sandbakken, E, Sandesh, D, Sanjesh, S, Schrotter, J, Shanthakumar, S, Sikka, P, Slaveykova, K, Studzinska, A, Subandi, F, Subedi, N, Sullivan, G, Tag, B, Delphine, T, Tamayo-Agudelo, W, Travaglino, G, Tuominen, J, Turk-Kurtca, T, Vakai, M, Volkodav, T, Wang, A, Williams, A, Wu, C, Yamada, Y, Yaneva, T, Yanez, N, Yeh, Y, Zoletic, E, Blackburn A. M., Vestergren S., Tran T. P., Stockli S., Griffin S. M., Ntontis E., Jeftic A., Chrona S., Ikizer G., Han H., Milfont T. L., Parry D., Byrne G., Gomez-Lopez M., Acosta A., Kowal M., De Leon G., Gallegos A., Perez M., Abdelrahman M., Ahern E., Yar A. W. A., Ahmed O., Alami N. H., Amin R., Andersen L. E., Araujo B. O., Asongu N. A., Bartsch F., Bavolar J., Bhatta K. R., Bircan T., Bita S., Bombuwala H., Brik T., Cakal H., Caniels M., Carballo M., Carvalho N. M., Cely L., Chang S., Chayinska M., Chen F. -Y., Ch'ng B., Chukwuorji J. B. C., Costa A. R., Dalizu V. L., Deschrijver E., Dilekler Aldemir I., Doherty A. M., Doller R., Dubrov D., Elegbede S., Elizalde J., Ermagan-Caglar E., Fernandez-Morales R., Garcia-Castro J. D., Gelpi R., Ghafori S., Goldberg X., Gonzalez-Uribe C., Alpizar-Rojas H., Haugestad C. A. P., Higuera D., Hoorelbeke K., Hristova E., Hubena B., Huq H., Ihaya K., Jayathilake G., Jen E., Jinadasa A., Joksimovic J., Kacmar P., Kadreva V., Kalinova K., Kandeel H. A. A., Kellezi B., Khan S., Kontogianni M., Koszalkowska K., Krzysztof H., Lacko D., Landa-Blanco M., Lee Y., Lieberoth A., Lins S., Liutsko L., Londero-Santos A., Mauritsen A. L., Maegli M. A., Magidie P., Maharjan R., Makaveeva T., Makhubela M., Malagon M. G., Malykh S., Mamede S., Mandillah S., Mansoor M. S., Mari S., Marin-Lopez I., Marot T. A., Martinez S., Mauka J., Moss S. M., Mushtaq A., Musliu A., Mususa D., Najmussaqib A., Nasheeda A., Nasr R., Machado N. N., Natividade J. C., Ngowi H. P., Nyarangi C., Ogunbode C., Onyutha C., Padmakumar K., Paniagua W., Pena M. C., Pirko M., Portela M., Pouretemad H., Rachev N., Ratodi M., Reifler J., Sadeghi S., Sahayanathan H. S., Sanchez E., Sandbakken E. M., Sandesh D., Sanjesh S., Schrotter J., Shanthakumar S., Sikka P., Slaveykova K., Studzinska A., Subandi F. D., Subedi N., Sullivan G. B., Tag B., Delphine T. E. A., Tamayo-Agudelo W., Travaglino G. A., Tuominen J., Turk-Kurtca T., Vakai M., Volkodav T., Wang A. H. -E. W., Williams A., Wu C., Yamada Y., Yaneva T., Yanez N., Yeh Y. -Y., and Zoletic E.

Abstract

During the onset of the COVID-19 pandemic, the COVIDiSTRESS Consortium launched an open-access global survey to understand and improve individuals’ experiences related to the crisis. A year later, we extended this line of research by launching a new survey to address the dynamic landscape of the pandemic. This survey was released with the goal of addressing diversity, equity, and inclusion by working with over 150 researchers across the globe who collected data in 48 languages and dialects across 137 countries. The resulting cleaned dataset described here includes 15,740 of over 20,000 responses. The dataset allows cross-cultural study of psychological wellbeing and behaviours a year into the pandemic. It includes measures of stress, resilience, vaccine attitudes, trust in government and scientists, compliance, and information acquisition and misperceptions regarding COVID-19. Open-access raw and cleaned datasets with computed scores are available. Just as our initial COVIDiSTRESS dataset has facilitated government policy decisions regarding health crises, this dataset can be used by researchers and policy makers to inform research, decisions, and policy.

Published
2022

21. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis

Author

Allotey, J, Whittle, R, Snell, K, Smuk, M, Townsend, R, von Dadelszen, P, Heazell, A, Magee, L, Smith, G, Sandall, J, Thilaganathan, B, Zamora, J, Riley, R, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, A, Salvesen, K, Bhattacharya, S, Uiterwaal, C, Staff, A, Andersen, L, Olive, E, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramirez, J, Masse, J, Audibert, F, Magnus, P, Jenum, A, Baschat, A, Ohkuchi, A, Mcauliffe, F, West, J, Askie, L, Mone, F, Farrar, D, Zimmerman, P, Smits, L, Riddell, C, Kingdom, J, van de Post, J, Illanes, S, Holzman, C, van Kuijk, S, Carbillon, L, Villa, P, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, van Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, C, Nagata, C, Brown, M, Vollebregt, K, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, J, Figueiro, E, Lapaire, O, Laivuori, H, Lykke, J, Conde-Agudelo, A, Galindo, A, Mbah, A, Betran, A, Herraiz, I, Trogstad, L, Steegers, E, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, W, Browne, J, Allen, R, Costa, F, Klipstein-Grobusch Browne, K, Crowther, C, Jorgensen, J, Forest, J, Rumbold, A, Mol, B, Giguere, Y, Kenny, L, Ganzevoort, W, Odibo, A, Myers, J, Yeo, S, Goffinet, F, Mccowan, L, Pajkrt, E, Teede, H, Haddad, B, Dekker, G, Kleinrouweler, E, Lecarpentier, E, Roberts, C, Groen, H, Skrastad, R, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, J, Monterio, I, Pillalis, A, Souza, R, Hawkins, L, Gabbay-Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K, Allotey J., Whittle R., Snell K. I. E., Smuk M., Townsend R., von Dadelszen P., Heazell A. E. P., Magee L., Smith G. C. S., Sandall J., Thilaganathan B., Zamora J., Riley R. D., Khalil A., Thangaratinam S., Coomarasamy A., Kwong A., Savitri A. I., Salvesen K. A., Bhattacharya S., Uiterwaal C. S. P. M., Staff A. C., Andersen L. B., Olive E. L., Redman C., Sletner L., Daskalakis G., Macleod M., Abdollahain M., Ramirez J. A., Masse J., Audibert F., Magnus P. M., Jenum A. K., Baschat A., Ohkuchi A., McAuliffe F. M., West J., Askie L. M., Mone F., Farrar D., Zimmerman P. A., Smits L. J. M., Riddell C., Kingdom J. C., van de Post J., Illanes S. E., Holzman C., van Kuijk S. M. J., Carbillon L., Villa P. M., Eskild A., Chappell L., Prefumo F., Velauthar L., Seed P., van Oostwaard M., Verlohren S., Poston L., Ferrazzi E., Vinter C. A., Nagata C., Brown M., Vollebregt K. C., Takeda S., Langenveld J., Widmer M., Saito S., Haavaldsen C., Carroli G., Olsen J., Wolf H., Zavaleta N., Eisensee I., Vergani P., Lumbiganon P., Makrides M., Facchinetti F., Sequeira E., Gibson R., Ferrazzani S., Frusca T., Norman J. E., Figueiro E. A., Lapaire O., Laivuori H., Lykke J. A., Conde-Agudelo A., Galindo A., Mbah A., Betran A. P., Herraiz I., Trogstad L., Smith G. G. S., Steegers E. A. P., Salim R., Huang T., Adank A., Zhang J., Meschino W. S., Browne J. L., Allen R. E., Costa F. D. S., Klipstein-Grobusch Browne K., Crowther C. A., Jorgensen J. S., Forest J. -C., Rumbold A. R., Mol B. W., Giguere Y., Kenny L. C., Ganzevoort W., Odibo A. O., Myers J., Yeo S. A., Goffinet F., McCowan L., Pajkrt E., Teede H. J., Haddad B. G., Dekker G., Kleinrouweler E. C., LeCarpentier E., Roberts C. T., Groen H., Skrastad R. B., Heinonen S., Eero K., Anggraini D., Souka A., Cecatti J. G., Monterio I., Pillalis A., Souza R., Hawkins L. A., Gabbay-Benziv R., Crovetto F., Figuera F., Jorgensen L., Dodds J., Patel M., Aviram A., Papageorghiou A., Khan K., Allotey, J, Whittle, R, Snell, K, Smuk, M, Townsend, R, von Dadelszen, P, Heazell, A, Magee, L, Smith, G, Sandall, J, Thilaganathan, B, Zamora, J, Riley, R, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, A, Salvesen, K, Bhattacharya, S, Uiterwaal, C, Staff, A, Andersen, L, Olive, E, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramirez, J, Masse, J, Audibert, F, Magnus, P, Jenum, A, Baschat, A, Ohkuchi, A, Mcauliffe, F, West, J, Askie, L, Mone, F, Farrar, D, Zimmerman, P, Smits, L, Riddell, C, Kingdom, J, van de Post, J, Illanes, S, Holzman, C, van Kuijk, S, Carbillon, L, Villa, P, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, van Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, C, Nagata, C, Brown, M, Vollebregt, K, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, J, Figueiro, E, Lapaire, O, Laivuori, H, Lykke, J, Conde-Agudelo, A, Galindo, A, Mbah, A, Betran, A, Herraiz, I, Trogstad, L, Steegers, E, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, W, Browne, J, Allen, R, Costa, F, Klipstein-Grobusch Browne, K, Crowther, C, Jorgensen, J, Forest, J, Rumbold, A, Mol, B, Giguere, Y, Kenny, L, Ganzevoort, W, Odibo, A, Myers, J, Yeo, S, Goffinet, F, Mccowan, L, Pajkrt, E, Teede, H, Haddad, B, Dekker, G, Kleinrouweler, E, Lecarpentier, E, Roberts, C, Groen, H, Skrastad, R, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, J, Monterio, I, Pillalis, A, Souza, R, Hawkins, L, Gabbay-Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K, Allotey J., Whittle R., Snell K. I. E., Smuk M., Townsend R., von Dadelszen P., Heazell A. E. P., Magee L., Smith G. C. S., Sandall J., Thilaganathan B., Zamora J., Riley R. D., Khalil A., Thangaratinam S., Coomarasamy A., Kwong A., Savitri A. I., Salvesen K. A., Bhattacharya S., Uiterwaal C. S. P. M., Staff A. C., Andersen L. B., Olive E. L., Redman C., Sletner L., Daskalakis G., Macleod M., Abdollahain M., Ramirez J. A., Masse J., Audibert F., Magnus P. M., Jenum A. K., Baschat A., Ohkuchi A., McAuliffe F. M., West J., Askie L. M., Mone F., Farrar D., Zimmerman P. A., Smits L. J. M., Riddell C., Kingdom J. C., van de Post J., Illanes S. E., Holzman C., van Kuijk S. M. J., Carbillon L., Villa P. M., Eskild A., Chappell L., Prefumo F., Velauthar L., Seed P., van Oostwaard M., Verlohren S., Poston L., Ferrazzi E., Vinter C. A., Nagata C., Brown M., Vollebregt K. C., Takeda S., Langenveld J., Widmer M., Saito S., Haavaldsen C., Carroli G., Olsen J., Wolf H., Zavaleta N., Eisensee I., Vergani P., Lumbiganon P., Makrides M., Facchinetti F., Sequeira E., Gibson R., Ferrazzani S., Frusca T., Norman J. E., Figueiro E. A., Lapaire O., Laivuori H., Lykke J. A., Conde-Agudelo A., Galindo A., Mbah A., Betran A. P., Herraiz I., Trogstad L., Smith G. G. S., Steegers E. A. P., Salim R., Huang T., Adank A., Zhang J., Meschino W. S., Browne J. L., Allen R. E., Costa F. D. S., Klipstein-Grobusch Browne K., Crowther C. A., Jorgensen J. S., Forest J. -C., Rumbold A. R., Mol B. W., Giguere Y., Kenny L. C., Ganzevoort W., Odibo A. O., Myers J., Yeo S. A., Goffinet F., McCowan L., Pajkrt E., Teede H. J., Haddad B. G., Dekker G., Kleinrouweler E. C., LeCarpentier E., Roberts C. T., Groen H., Skrastad R. B., Heinonen S., Eero K., Anggraini D., Souka A., Cecatti J. G., Monterio I., Pillalis A., Souza R., Hawkins L. A., Gabbay-Benziv R., Crovetto F., Figuera F., Jorgensen L., Dodds J., Patel M., Aviram A., Papageorghiou A., and Khan K.

Abstract

Objective: Stillbirth is a potentially preventable complication of pregnancy. Identifying women at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of delivery in order to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none has yet been validated externally. In this study, we externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis to assess their predictive performance. Methods: MEDLINE, EMBASE, DH-DATA and AMED databases were searched from inception to December 2020 to identify studies reporting stillbirth prediction models. Studies that developed or updated prediction models for stillbirth for use at any time during pregnancy were included. IPD from cohorts within the International Prediction of Pregnancy Complications (IPPIC) Network were used to validate externally the identified prediction models whose individual variables were available in the IPD. The risk of bias of the models and cohorts was assessed using the Prediction study Risk Of Bias ASsessment Tool (PROBAST). The discriminative performance of the models was evaluated using the C-statistic, and calibration was assessed using calibration plots, calibration slope and calibration-in-the-large. Performance measures were estimated separately in each cohort, as well as summarized across cohorts using random-effects meta-analysis. Clinical utility was assessed using net benefit. Results: Seventeen studies reporting the development of 40 prognostic models for stillbirth were identified. None of the models had been previously validated externally, and the full model equation was reported for only one-fifth (20%, 8/40) of the models. External validation was possible for three of these models, using IPD from 19 cohorts (491 201 pregnant women) within the IPPIC Network database. Based on evaluation of the model development studies, all three models had an overa

Published
2022

22. Living within the safe and just Earth system boundaries for blue water

Author

Stewart-Koster, B., Bunn, S.E., Green, P., Ndehedehe, C., Andersen, L., Armstrong McKay, D., Bai, X., DeClerck, F., Ebi, K., Gordon, C., Gupta, J., Hasan, S., Jacobson, L., Lade, S., Liverman, D., Loriani, S., Mohamed, A., Nakicenovic, N., Obura, D., Qin, D., Rammelt, C., Rocha, J., Rockström, J., Verburg, P., Zimm, C., Stewart-Koster, B., Bunn, S.E., Green, P., Ndehedehe, C., Andersen, L., Armstrong McKay, D., Bai, X., DeClerck, F., Ebi, K., Gordon, C., Gupta, J., Hasan, S., Jacobson, L., Lade, S., Liverman, D., Loriani, S., Mohamed, A., Nakicenovic, N., Obura, D., Qin, D., Rammelt, C., Rocha, J., Rockström, J., Verburg, P., and Zimm, C.

Abstract

Safe and just Earth system boundaries (ESBs) for surface water and groundwater (blue water) have been defined for sustainable water management in the Anthropocene. Here we assessed whether minimum human needs could be met with surface water from within individual river basins alone and, where this is not possible, quantified how much groundwater would be required. Approximately 2.6 billion people live in river basins where groundwater is needed because they are already outside the surface water ESB or have insufficient surface water to meet human needs and the ESB. Approximately 1.4 billion people live in river basins where demand-side transformations would be required as they either exceed the surface water ESB or face a decline in groundwater recharge and cannot meet minimum needs within the ESB. A further 1.5 billion people live in river basins outside the ESB, with insufficient surface water to meet minimum needs, requiring both supply- and demand-side transformations. These results highlight the challenges and opportunities of meeting even basic human access needs to water and protecting aquatic ecosystems.

Published
2023
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23. General practitioners’ stay-at-work practices in patients with musculoskeletal disorders:using Intervention Mapping to develop a training program

Author

Møller, A., Bond, C. B., Andersen, L. N., Hartvigsen, J., Stochkendahl, M. J., Møller, A., Bond, C. B., Andersen, L. N., Hartvigsen, J., and Stochkendahl, M. J.

Abstract

Objectives To describe current stay-at-work practices among Danish general practitioners (GPs) in relation to patients with musculoskeletal disorders, to identify potential avenues for improvement, and to suggest a training program for the GPs. Design and Setting We followed the principles of Intervention Mapping. Data were collected by means of literature searches, focus group interviews with GPs, and interaction with stakeholder representatives from the Danish labour market. Results GPs’ current stay-at-work practices were influenced by systemic, organisational, and legislative factors, and by personal determinants, including knowledge and skills relating to stay-at-work principles and musculoskeletal disorders, recognition of the patient’s risk of long-term work disability, their role as a GP, and expectations of interactions with other stay-at-work stakeholders. GPs described themselves as important partners and responsible for the diagnostic and holistic assessments of the patient but placed themselves on the side line relying on the patient or workplace stakeholders to act. Their practices are influenced both by patients, employers, and by other stakeholders. We propose a training course for GPs that incorporate both concrete tools and behaviour change techniques. Conclusions We have identified varied perspectives on the roles and responsibilities of GPs, as well as legislative and organisational barriers, and proposed a training program. Not all barriers identified can be addressed by a training course, and some questions are left unanswered, among others - who are best suited to help patients staying at work?, Objectives: To describe current stay-at-work practices among Danish general practitioners (GPs) in relation to patients with musculoskeletal disorders, to identify potential avenues for improvement, and to suggest a training program for the GPs. Design and Setting: We followed the principles of Intervention Mapping. Data were collected by means of literature searches, focus group interviews with GPs, and interaction with stakeholder representatives from the Danish labour market. Results: GPs’ current stay-at-work practices were influenced by systemic, organisational, and legislative factors, and by personal determinants, including knowledge and skills relating to stay-at-work principles and musculoskeletal disorders, recognition of the patient’s risk of long-term work disability, their role as a GP, and expectations of interactions with other stay-at-work stakeholders. GPs described themselves as important partners and responsible for the diagnostic and holistic assessments of the patient but placed themselves on the side line relying on the patient or workplace stakeholders to act. Their practices are influenced both by patients, employers, and by other stakeholders. We propose a training course for GPs that incorporate both concrete tools and behaviour change techniques. Conclusions: We have identified varied perspectives on the roles and responsibilities of GPs, as well as legislative and organisational barriers, and proposed a training program. Not all barriers identified can be addressed by a training course, and some questions are left unanswered, among others - who are best suited to help patients staying at work?.

Published
2023

24. Extracorporeal cardiopulmonary resuscitation for cardiac arrest: An updated systematic review

Author

Holmberg, M. J., Granfeldt, A., Guerguerian, A. -M., Sandroni, Claudio, Hsu, C. H., Gardner, R. M., Lind, P. C., Eggertsen, M. A., Johannsen, C. M., Andersen, L. W., Sandroni C. (ORCID:0000-0002-8878-2611), Holmberg, M. J., Granfeldt, A., Guerguerian, A. -M., Sandroni, Claudio, Hsu, C. H., Gardner, R. M., Lind, P. C., Eggertsen, M. A., Johannsen, C. M., Andersen, L. W., and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

Objectives: To provide an updated systematic review on the use of extracorporeal cardiopulmonary resuscitation (ECPR) compared with manual or mechanical cardiopulmonary resuscitation during cardiac arrest. Methods: This was an update of a systematic review published in 2018. OVID Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched for randomized trials and observational studies between January 1, 2018, and June 21, 2022. The population included adults and children with out-of-hospital or in-hospital cardiac arrest. Two investigators reviewed studies for relevance, extracted data, and assessed bias. The certainty of evidence was evaluated using GRADE. Results: The search identified 3 trials, 27 observational studies, and 6 cost-effectiveness studies. All trials included adults with out-of-hospital cardiac arrest and were terminated before enrolling the intended number of subjects. One trial found a benefit of ECPR in survival and favorable neurological status, whereas two trials found no statistically significant differences in outcomes. There were 23 observational studies in adults with out-of-hospital cardiac arrest or in combination with in-hospital cardiac arrest, and 4 observational studies in children with in-hospital cardiac arrest. Results of individual studies were inconsistent, although many studies favored ECPR. The risk of bias was intermediate for trials and critical for observational studies. The certainty of evidence was very low to low. Study heterogeneity precluded meta-analyses. The cost-effectiveness varied depending on the setting and the analysis assumptions. Conclusions: Recent randomized trials suggest potential benefit of ECPR, but the certainty of evidence remains low. It is unclear which patients might benefit from ECPR.

Published
2023

25. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Berg, K. M., Bray, J. E., Ng, K. -C., Liley, H. G., Greif, R., Carlson, J. N., Morley, P. T., Drennan, I. R., Smyth, M., Scholefield, B. R., Weiner, G. M., Cheng, A., Djarv, T., Abelairas-Gomez, C., Acworth, J., Andersen, L. W., Atkins, D. L., Berry, D. C., Bhanji, F., Bierens, J., Couto, T. B., Borra, V., Bottiger, B. W., Bradley, R. N., Breckwoldt, J., Cassan, P., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Dassanayake, V., Davis, P. G., Dawson, J. A., de Almeida, M. F., De Caen, A. R., Deakin, C. D., Dicker, B., Douma, M. J., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Fijacko, N., Finn, J. C., Flores, G. E., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M. E., Kloeck, D. A., Kudenchuk, P., Kule, A., Kurosawa, H., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y., Lockey, A. S., Macneil, F., Maconochie, I. K., Madar, R. J., Hansen, C. M., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Monnelly, V., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., Ohshimo, S., Olasveengen, T. M., Ong, Y. -K. G., Orkin, A. M., Parr, M. J., Patocka, C., Perkins, G. D., Perlman, J. M., Rabi, Y., Raitt, J., Ramachandran, S., Ramaswamy, V. V., Raymond, T. T., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Singletary, E. M., Skrifvars, M. B., Smith, C. M., Soar, J., Stassen, W., Sugiura, T., Tijssen, J. A., Topjian, A. A., Trevisanuto, D., Vaillancourt, C., Wyckoff, M. H., Wyllie, J. P., Yang, C. -W., Yeung, J., Zelop, C. M., Zideman, D. A., Nolan, J. P., Barcala-Furelos, R., Beerman, S. B., Bruckner, M., Castren, M., Chong, S., Claesson, A., Dunne, C. L., Finan, E., Fukuda, T., Ganesan, S. L., Gately, C., Gois, A., Gray, S., Halamek, L. P., Hoover, A. V., Hurst, C., Josephsen, J., Kollander, L., Kamlin, C. O., Kool, M., Li, L., Mecrow, T. S., Montgomery, W., Ristau, P., Jayashree, M., Schmidt, A., Scquizzato, T. -M., Seesink, J., Sempsrott, J., Solevag, A. L., Strand, M. L., Szpilman, D., Szyld, E., Thom, O., Tobin, J. M., Trang, J., Webber, J., Webster, H. K., Wellsford, M., Sandroni C. (ORCID:0000-0002-8878-2611), Berg, K. M., Bray, J. E., Ng, K. -C., Liley, H. G., Greif, R., Carlson, J. N., Morley, P. T., Drennan, I. R., Smyth, M., Scholefield, B. R., Weiner, G. M., Cheng, A., Djarv, T., Abelairas-Gomez, C., Acworth, J., Andersen, L. W., Atkins, D. L., Berry, D. C., Bhanji, F., Bierens, J., Couto, T. B., Borra, V., Bottiger, B. W., Bradley, R. N., Breckwoldt, J., Cassan, P., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Dassanayake, V., Davis, P. G., Dawson, J. A., de Almeida, M. F., De Caen, A. R., Deakin, C. D., Dicker, B., Douma, M. J., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Fijacko, N., Finn, J. C., Flores, G. E., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M. E., Kloeck, D. A., Kudenchuk, P., Kule, A., Kurosawa, H., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y., Lockey, A. S., Macneil, F., Maconochie, I. K., Madar, R. J., Hansen, C. M., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Monnelly, V., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., Ohshimo, S., Olasveengen, T. M., Ong, Y. -K. G., Orkin, A. M., Parr, M. J., Patocka, C., Perkins, G. D., Perlman, J. M., Rabi, Y., Raitt, J., Ramachandran, S., Ramaswamy, V. V., Raymond, T. T., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Singletary, E. M., Skrifvars, M. B., Smith, C. M., Soar, J., Stassen, W., Sugiura, T., Tijssen, J. A., Topjian, A. A., Trevisanuto, D., Vaillancourt, C., Wyckoff, M. H., Wyllie, J. P., Yang, C. -W., Yeung, J., Zelop, C. M., Zideman, D. A., Nolan, J. P., Barcala-Furelos, R., Beerman, S. B., Bruckner, M., Castren, M., Chong, S., Claesson, A., Dunne, C. L., Finan, E., Fukuda, T., Ganesan, S. L., Gately, C., Gois, A., Gray, S., Halamek, L. P., Hoover, A. V., Hurst, C., Josephsen, J., Kollander, L., Kamlin, C. O., Kool, M., Li, L., Mecrow, T. S., Montgomery, W., Ristau, P., Jayashree, M., Schmidt, A., Scquizzato, T. -M., Seesink, J., Sempsrott, J., Solevag, A. L., Strand, M. L., Szpilman, D., Szyld, E., Thom, O., Tobin, J. M., Trang, J., Webber, J., Webster, H. K., Wellsford, M., and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

The International Liaison Committee on Resuscitation engages in a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation and first aid science. Draft Consensus on Science With Treatment Recommendations are posted online throughout the year, and this annual summary provides more concise versions of the final Consensus on Science With Treatment Recommendations from all task forces for the year. Topics addressed by systematic reviews this year include resuscitation of cardiac arrest from drowning, extracorporeal cardiopulmonary resuscitation for adults and children, calcium during cardiac arrest, double sequential defibrillation, neuroprognostication after cardiac arrest for adults and children, maintaining normal temperature after preterm birth, heart rate monitoring methods for diagnostics in neonates, detection of exhaled carbon dioxide in neonates, family presence during resuscitation of adults, and a stepwise approach to resuscitation skills training. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, using Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence-to-Decision Framework Highlights sections. In addition, the task forces list priority knowledge gaps for further research. Additional topics are addressed with scoping reviews and evidence updates.

Published
2023

28. Molecular basis and design principles of switchable front-rear polarity and directional migration in Myxococcus xanthus

Author

Carreira, L., Szadkowski, D., Lometto, S., Hochberg, G., https://orcid.org/0000-0002-7155-0451, Søgaard-Andersen, L., and https://orcid.org/0000-0002-0674-0013

Abstract

During cell migration, front-rear polarity is spatiotemporally regulated; however, the underlying design of regulatory interactions varies. In rod-shaped Myxococcus xanthus cells, a spatial toggle switch dynamically regulates front-rear polarity. The polarity module establishes front-rear polarity by guaranteeing front pole-localization of the small GTPase MglA. Conversely, the Frz chemosensory system, by acting on the polarity module, causes polarity inversions. MglA localization depends on the RomR/RomX GEF and MglB/RomY GAP complexes that localize asymmetrically to the poles by unknown mechanisms. Here, we show that RomR and the MglB and MglC roadblock domain proteins generate a positive feedback by forming a RomR/MglC/MglB complex, thereby establishing the rear pole with high GAP activity that is non-permissive to MglA. MglA at the front engages in negative feedback that breaks the RomR/MglC/MglB positive feedback allosterically, thus ensuring low GAP activity at this pole. These findings unravel the design principles of a system for switchable front-rear polarity.

Published
2023

29. Gender differences in the distribution of children's physical activity: evidence from nine countries.

Author

Kretschmer, Luke, Salali, Gul Deniz, Andersen, Lars Bo, Hallal, Pedro C., Northstone, Kate, Sardinha, Luís B., Dyble, Mark, Bann, David, Andersen, L. B., Anderssen, S., Cardon, G., Davey, R., Jago, R., Janz, K. F., Kriemler, S., Møller, N., Northstone, K., Pate, R., Puder, J. J., and Reilly, J.

Subjects
DATABASES, SEDENTARY lifestyles, CHILD development, SEX distribution, PHYSICAL activity, ACCELEROMETRY, DESCRIPTIVE statistics, RESEARCH funding, EXERCISE, EXERCISE intensity, DATA analysis software
Abstract

Background: Physical activity in childhood is thought to influences health and development. Previous studies have found that boys are typically more active than girls, yet the focus has largely been on differences in average levels or proportions above a threshold rather than the full distribution of activity across all intensities. We thus examined differences in the distribution of physical activity between girls and boys in a multi-national sample of children. Methods: We used the harmonised International Children Accelerometry Database (ICAD), including waist-worn accelerometry data from 15,461 individuals (Boys: 48.3%) from 9 countries. Employing Generalised Additive Models of Location, Shape, and Scale (GAMLSS) we investigated gender differences in the distribution of individuals, including comparisons of variability (SD) and average physical activity levels (mean and median) and skewness. We conducted this analysis for each activity intensity (Sedentary, Light, and Moderate-to-Vigorous (MVPA)) and a summary measure (counts per minute (CPM)). Results: Sizable gender differences in the distribution of activity were found for moderate to vigorous activity and counts per minute, with boys having higher average levels (38% higher mean volumes of MVPA, 20% higher CPM), yet substantially more between-person variability (30% higher standard deviation (SD) for MVPA, 17% higher SD for CPM); boys' distributions were less positively skewed than girls. Conversely, there was little to no difference between girls and boys in the distribution of sedentary or light-intensity activity. Conclusions: Inequality in activity between girls and boys was driven by MVPA. The higher mean volumes of MVPA in boys occurred alongside greater variability. This suggests a need to consider the underlying distribution of activity in future research; for example, interventions which target gender inequality in MVPA may inadvertently lead to increased inequality within girls. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial

Author

Jensen, Jens-Ulrik S., Itenov, Theis S., Thormar, Katrin M., Hein, Lars, Mohr, Thomas T., Andersen, Mads H., Løken, Jesper, Tousi, Hamid, Lundgren, Bettina, Boesen, Hans Christian, Johansen, Maria E., Ostrowski, Sisse R., Johansson, Pär I., Grarup, Jesper, Vestbo, Jørgen, Lundgren, Jens D., Steensen, M., Thornberg, K., Bestle, M., Strange, D., Lauritsen, A. Ø., Søe-Jensen, P., Reiter, N., Drenck, N. E., Fjeldborg, P., Fox, Z., Kjær, J., Kristensen, D., Rasmussen, M. B., Hallas, C. S.v., Zacho, M., Østergaard, C., Petersen, P. L., Hougaard, S., Mantoni, T., Nebrich, L., Bendtsen, A., Andersen, L. H., Bærentzen, F., Eversbusch, Andreas, Bømler, B., Martusevicius, R., Nielsen, T., Bådstøløkken, P. M., Grevstad, U., Hallas, P., Lindhardt, A., Galle, T., Graeser, K., Hohwu-Christensen, E., Gregersen, P., Pedersen, L. M., Rye, I., Cordtz, J., Madsen, K. R., Kirkegaard, P. R. C., Findsen, L., Nielsen, L. H., Pedersen, D. H., Andersen, J. H., Albrechtsen, C., Jacobsen, A., Jansen, T., Jensen, A. G., Jørgensen, H. H., Vazin, M., Lipsius, L., Skielboe, M., Thage, B., Thoft, C., Uldbjerg, M., Anderlo, E., Engsig, M., Hani, F., Jacobsen, R. B., Mulla, L., Skram, U., Waldau, T., Faber, T., Andersen, B., Gillesberg, I., Christensen, A., Hartmann, C., Albret, R., Dinesen, D. S., Gani, K., Ibsen, M., Petersen, J. A., Carl, P., Gade, E., Solevad, D., Heiring, C., Jørgensen, M., Ekelund, K., Afshari, A., Hammer, N., Bitsch, M., Hansen, J. S., Wamberg, C., Clausen, T. D., Winkel, R., Huusom, J., Buck, D. L., Grevstad, U., Lenz, K., Mellado, P., Karacan, H., Hidestål, J., Høgagard, J., Højbjerg, J., Højlund, J., Hestad, S., Østergaard, M., Wesche, N., Nielsen, S. A., Christensen, H., Blom, H., Jensen, C. H., Nielsen, K., Holler, N. G., Rossau, C. D., Glæemose, M., Wranér, M. B., Thomsen, C. B., Rasmussen, B., Lund-Rasmussen, C., Bech, B., Bjerregaard, K., Spliid, L., Nielsen, L. L. W., Larsen, K. M., Goldinger, M., Illum, D., Jessen, C., Christiansen, A., Berg, A., Elkmann, T., Pedersen, J. A. K., Simonsen, M., Joensen†, H., Alstrøm, H., Svane, C., Engquist, A., and For The Procalcitonin And Survival Study (PASS) Group

Published
2016
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31. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016

Author

Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Endacott, R., Maistry, N., van Wijk, A., Rouw, N., van Galen, T., Evelein-Brugman, S., Taggu, A., Krishna, B., Sampath, S., Putzu, A., Fang, M., Berto, M. Boscolo, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, S. T., Toh, C. H., Han, H. S., Gil, E. M., Lee, D. S., Park, C. M., Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, M. W., Huang, W. C., Chiang, C. H., Hung, W. T., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Shu, C. W., Kang, P. L., Mar, G. Y., Liu, C. P., Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, M. F., Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, J. L., Garcia-Gigorro, R., Peiretti, M. A. Corres, Lopez-Gude, M. 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E., Ackerley, C., Yoshida, T., Zabini, D., Otulakowski, G., Post, M., Kuebler, W. M., McNamara, P. J., Kavanagh, B. P., Pirracchio, R., Rigon, M. Resche, Carone, M., Chevret, S., Annane, D., Eladawy, S., El-Hamamsy, M., Bazan, N., Elgendy, M., De Pascale, G., Vallecoccia, M. S., Cutuli, S. L., Di Gravio, V., Pennisi, M. A., Conti, G., Antonelli, M., Andreis, D. T., Khaliq, W., Singer, M., Hartmann, J., Harm, S., Carmona, S. Alcantara, Almudevar, P. Matia, Abellán, A. Naharro, Ramos, J. Veganzones, Pérez, L. Pérez, Valbuena, B. Lobo, Sanz, N. Martínez, Simón, I. Fernández, Arrigo, M., Feliot, E., Deye, N., Cariou, A., Guidet, B., Jaber, S., Leone, M., Resche-Rigon, M., Baron, A. Vieillard, Legrand, M., Gayat, E., Mebazaa, A., Balik, M., Kolnikova, I., Maly, M., Waldauf, P., Tavazzi, G., Kristof, J., Herpain, A., Su, F., Post, E., Taccone, F., Vincent, J. L., Creteur, J., Lee, C., Hatib, F., Jian, Z., Buddi, S., Cannesson, M., Fileković, S., Turel, M., Knafelj, R., Gorjup, V., Stanić, R., Gradišek, P., Cerović, O., Mirković, T., Noč, M., Tirkkonen, J., Hellevuo, H., Olkkola, K. T., Hoppu, S., Lin, K. C., Hung, W. T., Chiang, C. C., Huang, W. C., Juan, W. C., Lin, S. C., Cheng, C. C., Lin, P. H., Fong, K. Y., Hou, D. S., Kang, P. L., Wann, S. R., Chen, Y. S., Mar, G. Y., Liu, C. P., Paul, M., Bougouin, W., Geri, G., Dumas, F., Champigneulle, B., Legriel, S., Charpentier, J., Mira, J. P., Sandroni, C., Cariou, A., Zimmerman, J., Sullivan, E., Noursadeghi, M., Fox, B., Sampson, D., McHugh, L., Yager, T., Cermelli, S., Seldon, T., Bhide, S., Brandon, R. A., Brandon, R. B., Zwaag, J., Beunders, R., Pickkers, P., Kox, M., Gul, F., Arslantas, M. K., Genc, D., Zibandah, N., Topcu, L., Akkoc, T., Cinel, I., Greco, E., Lauretta, M. P., Andreis, D. T., Singer, M., Garcia, I. Palacios, Cordero, M., Martin, A. Diaz, Pallás, T. Aldabó, Montero, J. 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2016
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32. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis

Author

Allotey, J., Whittle, R., Snell, K. I. E., Smuk, M., Townsend, R., von Dadelszen, P., Heazell, A. E. P., Magee, L., Smith, G. C. S., Sandall, J., Thilaganathan, B., Zamora, J., Riley, R. D., Khalil, A., Thangaratinam, S., Coomarasamy, A., Kwong, A., Savitri, A. I., Salvesen, K. A., Bhattacharya, S., Uiterwaal, C. S. P. M., Staff, A. C., Andersen, L. B., Olive, E. L., Redman, C., Sletner, L., Daskalakis, G., Macleod, M., Abdollahain, M., Ramirez, J. A., Masse, J., Audibert, F., Magnus, P. M., Jenum, A. K., Baschat, A., Ohkuchi, A., Mcauliffe, F. M., West, J., Askie, L. M., Mone, F., Farrar, D., Zimmerman, P. A., Smits, L. J. M., Riddell, C., Kingdom, J. C., van de Post, J., Illanes, S. E., Holzman, C., van Kuijk, S. M. J., Carbillon, L., Villa, P. M., Eskild, A., Chappell, L., Prefumo, F., Velauthar, L., Seed, P., van Oostwaard, M., Verlohren, S., Poston, L., Ferrazzi, E., Vinter, C. A., Nagata, C., Brown, M., Vollebregt, K. C., Takeda, S., Langenveld, J., Widmer, M., Saito, S., Haavaldsen, C., Carroli, G., Olsen, J., Wolf, H., Zavaleta, N., Eisensee, I., Vergani, P., Lumbiganon, P., Makrides, M., Facchinetti, F., Sequeira, E., Gibson, R., Ferrazzani, S., Frusca, T., Norman, J. E., Figueiro, E. A., Lapaire, O., Laivuori, H., Lykke, J. A., Conde-Agudelo, A., Galindo, A., Mbah, A., Betran, A. P., Herraiz, I., Trogstad, L., Smith, G. G. S., Steegers, E. A. P., Salim, R., Huang, T., Adank, A., Zhang, J., Meschino, W. S., Browne, J. L., Allen, R. E., Costa, F. D. S., Klipstein-Grobusch Browne, K., Crowther, C. A., Jorgensen, J. S., Forest, J. -C., Rumbold, A. R., Mol, B. W., Giguere, Y., Kenny, L. C., Ganzevoort, W., Odibo, A. O., Myers, J., Yeo, S. A., Goffinet, F., Mccowan, L., Pajkrt, E., Teede, H. J., Haddad, B. G., Dekker, G., Kleinrouweler, E. C., Lecarpentier, E., Roberts, C. T., Groen, H., Skrastad, R. B., Heinonen, S., Eero, K., Anggraini, D., Souka, A., Cecatti, J. G., Monterio, I., Pillalis, A., Souza, R., Hawkins, L. A., Gabbay-Benziv, R., Crovetto, F., Figuera, F., Jorgensen, L., Dodds, J., Patel, M., Aviram, A., Papageorghiou, A., Khan, K., Clinicum, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital, Allotey, J, Whittle, R, Snell, K, Smuk, M, Townsend, R, von Dadelszen, P, Heazell, A, Magee, L, Smith, G, Sandall, J, Thilaganathan, B, Zamora, J, Riley, R, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, A, Salvesen, K, Bhattacharya, S, Uiterwaal, C, Staff, A, Andersen, L, Olive, E, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramirez, J, Masse, J, Audibert, F, Magnus, P, Jenum, A, Baschat, A, Ohkuchi, A, Mcauliffe, F, West, J, Askie, L, Mone, F, Farrar, D, Zimmerman, P, Smits, L, Riddell, C, Kingdom, J, van de Post, J, Illanes, S, Holzman, C, van Kuijk, S, Carbillon, L, Villa, P, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, van Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, C, Nagata, C, Brown, M, Vollebregt, K, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, J, Figueiro, E, Lapaire, O, Laivuori, H, Lykke, J, Conde-Agudelo, A, Galindo, A, Mbah, A, Betran, A, Herraiz, I, Trogstad, L, Steegers, E, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, W, Browne, J, Allen, R, Costa, F, Klipstein-Grobusch Browne, K, Crowther, C, Jorgensen, J, Forest, J, Rumbold, A, Mol, B, Giguere, Y, Kenny, L, Ganzevoort, W, Odibo, A, Myers, J, Yeo, S, Goffinet, F, Mccowan, L, Pajkrt, E, Teede, H, Haddad, B, Dekker, G, Kleinrouweler, E, Lecarpentier, E, Roberts, C, Groen, H, Skrastad, R, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, J, Monterio, I, Pillalis, A, Souza, R, Hawkins, L, Gabbay-Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K, Tampere University, Obstetrics and Gynaecology, APH - Quality of Care, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, APH - Digital Health, and Obstetrics and gynaecology

Subjects
Calibration (statistics), Perinatal Death, Overfitting, Cohort Studies, Fetal Development, 0302 clinical medicine, Discriminative model, 3123 Gynaecology and paediatrics, Models, Pregnancy, GROWTH RESTRICTION, Statistics, Medicine, Prenatal, 030212 general & internal medicine, Ultrasonography, RISK, 030219 obstetrics & reproductive medicine, PRETERM, Radiological and Ultrasound Technology, LOW-DOSE ASPIRIN, DIAGNOSIS TRIPOD, Obstetrics and Gynecology, General Medicine, Statistical, Stillbirth, Prognosis, Pregnancy Complication, external validation, individual participant data, intrauterine death, prediction model, stillbirth, Female, Humans, Infant, Newborn, Models, Statistical, Pregnancy Complications, Regression Analysis, Risk Assessment, Ultrasonography, Prenatal, 3. Good health, PREECLAMPSIA, Meta-analysis, Human, Cohort study, Prognosi, MEDLINE, Regression Analysi, WEEKS GESTATION, 03 medical and health sciences, VELOCIMETRY, Radiology, Nuclear Medicine and imaging, RECURRENCE, business.industry, Infant, Newborn, R1, HYPERTENSIVE DISORDERS, Reproductive Medicine, Sample size determination, Cohort Studie, RG, business, RA, Predictive modelling
Abstract

Objective Stillbirth is a potentially preventable complication of pregnancy. Identifying women at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of delivery in order to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none has yet been validated externally. In this study, we externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis to assess their predictive performance. Methods MEDLINE, EMBASE, DH-DATA and AMED databases were searched from inception to December 2020 to identify studies reporting stillbirth prediction models. Studies that developed or updated prediction models for stillbirth for use at any time during pregnancy were included. IPD from cohorts within the International Prediction of Pregnancy Complications (IPPIC) Network were used to validate externally the identified prediction models whose individual variables were available in the IPD. The risk of bias of the models and cohorts was assessed using the Prediction study Risk Of Bias ASsessment Tool (PROBAST). The discriminative performance of the models was evaluated using the C-statistic, and calibration was assessed using calibration plots, calibration slope and calibration-in-the-large. Performance measures were estimated separately in each cohort, as well as summarized across cohorts using random-effects meta-analysis. Clinical utility was assessed using net benefit. Results Seventeen studies reporting the development of 40 prognostic models for stillbirth were identified. None of the models had been previously validated externally, and the full model equation was reported for only one-fifth (20%, 8/40) of the models. External validation was possible for three of these models, using IPD from 19 cohorts (491 201 pregnant women) within the IPPIC Network database. Based on evaluation of the model development studies, all three models had an overall high risk of bias, according to PROBAST. In the IPD meta-analysis, the models had summary C-statistics ranging from 0.53 to 0.65 and summary calibration slopes ranging from 0.40 to 0.88, with risk predictions that were generally too extreme compared with the observed risks. The models had little to no clinical utility, as assessed by net benefit. However, there remained uncertainty in the performance of some models due to small available sample sizes. Conclusions The three validated stillbirth prediction models showed generally poor and uncertain predictive performance in new data, with limited evidence to support their clinical application. The findings suggest methodological shortcomings in their development, including overfitting. Further research is needed to further validate these and other models, identify stronger prognostic factors and develop more robust prediction models. (c) 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Published
2022
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35. The unexplored role of sedentary time and physical activity in glucose and lipid metabolism-related placental mRNAs in pregnant women who are obese:the DALI lifestyle randomised controlled trial

Author

Acosta-Manzano, P., Leopold-Posch, B., Simmons, D., Devlieger, R., Galjaard, S., Corcoy, R., Adelantado, J. M., Dunne, F., Harreiter, J., Kautzky-Willer, A., Damm, P., Mathiesen, E. R., Jensen, D. M., Andersen, L. L., Tanvig, M., Lapolla, A., Dalfra, M. G., Bertolotto, A., Wender-Ozegowska, E., Zawiejska, A., Hill, D. J., Snoek, F. J., Jelsma, J. G.M., Desoye, G., van Poppel, M. N.M., Acosta-Manzano, P., Leopold-Posch, B., Simmons, D., Devlieger, R., Galjaard, S., Corcoy, R., Adelantado, J. M., Dunne, F., Harreiter, J., Kautzky-Willer, A., Damm, P., Mathiesen, E. R., Jensen, D. M., Andersen, L. L., Tanvig, M., Lapolla, A., Dalfra, M. G., Bertolotto, A., Wender-Ozegowska, E., Zawiejska, A., Hill, D. J., Snoek, F. J., Jelsma, J. G.M., Desoye, G., and van Poppel, M. N.M.

Published
2022

36. COVIDiSTRESS diverse dataset on psychological and behavioural outcomes one year into the COVID-19 pandemic

Author

Blackburn, A. M., Vestergren, S., Tran, T. P., Stöckli, S., Griffin, S. M., Ntontis, E., Jeftic, A., Chrona, S., Ikizer, G., Mandillah, S., Chang, S., Sahayanathan, H. S., Sanchez, E., Sandbakken, E. M., Sandesh, D., Sanjesh, S., Schrötter, J., Shanthakumar, S., Sikka, P., Slaveykova, K., Studzinska, A., Chayinska, M., Byrne, G., Subandi, F. D., Subedi, N., Sullivan, G. B., Tag, B., Delphine, T. E. A., Tamayo-Agudelo, W., Travaglino, G. A., Tuominen, J., Türk-Kurtça, T., Chen, F. -Y., Vakai, M., Gómez-López, M., Volkodav, T., Wang, A. H. -E. W., Williams, A., Wu, C., Yamada, Y., Yaneva, T., Yañez, N., Yeh, Y. -Y., Ch’ng, B., Zoletic, E., Acosta, A., Kowal, M., De, Leon, G., Gallegos, A., Perez, M., Abdelrahman, M., Ahern, E., Yar, A. W. A., Ahmed, O., Chukwuorji, J. B. C., Alami, N. H., Amin, R., Andersen, L. E., Araújo, B. O., Asongu, N. A., Bartsch, F., Bavoľár, J., Bhatta, K. R., Bircan, T., Bita, S., Costa, A. R., Bombuwala, H., Brik, T., Cakal, H., Caniëls, M., Carballo, M., Carvalho, N. M., Cely, L., Dalizu, V. L., Deschrijver, E., Dilekler, Aldemir, İ., Doherty, A. M., Mansoor, M. S., Doller, R., Dubrov, D., Elegbede, S., Elizalde, J., Ermagan-Caglar, E., Fernández-Morales, R., García-Castro, J. D., Gelpí, R., Ghafori, S., Goldberg, X., Mari, S., González-Uribe, C., Alpízar-Rojas, H., Haugestad, C. A. P., Higuera, D., Hoorelbeke, K., Hristova, E., Hubená, B., Huq, H., Ihaya, K., Jayathilake, G., Marín-López, I., Jen, E., Jinadasa, A., Joksimovic, J., Kačmár, P., Kadreva, V., Kalinova, K., Kandeel, H. A. A., Kellezi, B., Khan, S., Kontogianni, M., Marot, T. A., Koszałkowska, K., Krzysztof, H., Lacko, D., Landa-Blanco, M., Lee, Y., Lieberoth, A., Lins, S., Liutsko, L., Londero-Santos, A., Mauritsen, A. L., Martínez, S., Maegli, M. A., Magidie, P., Maharjan, R., Makaveeva, T., Makhubela, M., Malagón, M. G., Malykh, S., Mamede, S., Mauka, J., Moss, S. M., Mushtaq, A., Musliu, A., Han, H., Mususa, D., Najmussaqib, A., Nasheeda, A., Nasr, R., Machado, N. N., Natividade, J. C., Ngowi, H. P., Nyarangi, C., Ogunbode, C., Onyutha, C., Milfont, T. L., Padmakumar, K., Paniagua, W., Pena, M. C., Pírko, M., Portela, M., Pouretemad, H., Rachev, N., Ratodi, M., Reifler, J., Sadeghi, S., Parry, D., Blackburn, A. M., Vestergren, S., Tran, T. P., Stöckli, S., Griffin, S. M., Ntontis, E., Jeftic, A., Chrona, S., Ikizer, G., Mandillah, S., Chang, S., Sahayanathan, H. S., Sanchez, E., Sandbakken, E. M., Sandesh, D., Sanjesh, S., Schrötter, J., Shanthakumar, S., Sikka, P., Slaveykova, K., Studzinska, A., Chayinska, M., Byrne, G., Subandi, F. D., Subedi, N., Sullivan, G. B., Tag, B., Delphine, T. E. A., Tamayo-Agudelo, W., Travaglino, G. A., Tuominen, J., Türk-Kurtça, T., Chen, F. -Y., Vakai, M., Gómez-López, M., Volkodav, T., Wang, A. H. -E. W., Williams, A., Wu, C., Yamada, Y., Yaneva, T., Yañez, N., Yeh, Y. -Y., Ch’ng, B., Zoletic, E., Acosta, A., Kowal, M., De, Leon, G., Gallegos, A., Perez, M., Abdelrahman, M., Ahern, E., Yar, A. W. A., Ahmed, O., Chukwuorji, J. B. C., Alami, N. H., Amin, R., Andersen, L. E., Araújo, B. O., Asongu, N. A., Bartsch, F., Bavoľár, J., Bhatta, K. R., Bircan, T., Bita, S., Costa, A. R., Bombuwala, H., Brik, T., Cakal, H., Caniëls, M., Carballo, M., Carvalho, N. M., Cely, L., Dalizu, V. L., Deschrijver, E., Dilekler, Aldemir, İ., Doherty, A. M., Mansoor, M. S., Doller, R., Dubrov, D., Elegbede, S., Elizalde, J., Ermagan-Caglar, E., Fernández-Morales, R., García-Castro, J. D., Gelpí, R., Ghafori, S., Goldberg, X., Mari, S., González-Uribe, C., Alpízar-Rojas, H., Haugestad, C. A. P., Higuera, D., Hoorelbeke, K., Hristova, E., Hubená, B., Huq, H., Ihaya, K., Jayathilake, G., Marín-López, I., Jen, E., Jinadasa, A., Joksimovic, J., Kačmár, P., Kadreva, V., Kalinova, K., Kandeel, H. A. A., Kellezi, B., Khan, S., Kontogianni, M., Marot, T. A., Koszałkowska, K., Krzysztof, H., Lacko, D., Landa-Blanco, M., Lee, Y., Lieberoth, A., Lins, S., Liutsko, L., Londero-Santos, A., Mauritsen, A. L., Martínez, S., Maegli, M. A., Magidie, P., Maharjan, R., Makaveeva, T., Makhubela, M., Malagón, M. G., Malykh, S., Mamede, S., Mauka, J., Moss, S. M., Mushtaq, A., Musliu, A., Han, H., Mususa, D., Najmussaqib, A., Nasheeda, A., Nasr, R., Machado, N. N., Natividade, J. C., Ngowi, H. P., Nyarangi, C., Ogunbode, C., Onyutha, C., Milfont, T. L., Padmakumar, K., Paniagua, W., Pena, M. C., Pírko, M., Portela, M., Pouretemad, H., Rachev, N., Ratodi, M., Reifler, J., Sadeghi, S., and Parry, D.

Abstract

During the onset of the COVID-19 pandemic, the COVIDiSTRESS Consortium launched an open-access global survey to understand and improve individuals’ experiences related to the crisis. A year later, we extended this line of research by launching a new survey to address the dynamic landscape of the pandemic. This survey was released with the goal of addressing diversity, equity, and inclusion by working with over 150 researchers across the globe who collected data in 48 languages and dialects across 137 countries. The resulting cleaned dataset described here includes 15,740 of over 20,000 responses. The dataset allows cross-cultural study of psychological wellbeing and behaviours a year into the pandemic. It includes measures of stress, resilience, vaccine attitudes, trust in government and scientists, compliance, and information acquisition and misperceptions regarding COVID-19. Open-access raw and cleaned datasets with computed scores are available. Just as our initial COVIDiSTRESS dataset has facilitated government policy decisions regarding health crises, this dataset can be used by researchers and policy makers to inform research, decisions, and policy. © 2022, The Author(s).

Published
2022

37. 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations: Summary from the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; And First Aid Task Forces

Author

Wyckoff, M. H., Greif, R., Morley, P. T., Ng, K. -C., Olasveengen, T. M., Singletary, E. M., Soar, J., Cheng, A., Drennan, I. R., Liley, H. G., Scholefield, B. R., Smyth, M. A., Welsford, M., Zideman, D. A., Acworth, J., Aickin, R., Andersen, L. W., Atkins, D., Berry, D. C., Bhanji, F., Bierens, J., Borra, V., Bottiger, B. W., Bradley, R. N., Bray, J. E., Breckwoldt, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Couto, T. B., Dainty, K. N., Davis, P. G., De Almeida, M. F., De Caen, A. R., Deakin, C. D., Djarv, T., Donnino, M. W., Douma, M. J., Duff, J. P., Dunne, C. L., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Finn, J., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M., Kloeck, D. A., Kudenchuk, P. J., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y. (., Lockey, A. S., Maconochie, I. K., Madar, R. J., Malta Hansen, C., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Morgan, P., Morrison, L. J., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., O'Neill, B. J., Ong, Y. -K. G., Orkin, A. M., Paiva, E. F., Parr, M. J., Patocka, C., Pellegrino, J. L., Perkins, G. D., Perlman, J. M., Rabi, Y., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Skrifvars, M. B., Smith, C. M., Sugiura, T., Tijssen, J. A., Trevisanuto, D., Van De Voorde, P., Wang, T. -L., Weiner, G. M., Wyllie, J. P., Yang, C. -W., Yeung, J., Nolan, J. P., Berg, K. M., Burdick, M. C., Cartledge, S., Dawson, J. A., Elgohary, M. M., Ersdal, H. L., Finan, E., Flaatten, H. I., Flores, G. E., Fuerch, J., Garg, R., Gately, C., Goh, M., Halamek, L. P., Handley, A. J., Hatanaka, T., Hoover, A., Issa, M., Johnson, S., Kamlin, C. O., Ko, Y. -C., Kule, A., Leone, T. A., Mackenzie, E., Macneil, F., Montgomery, W., O'Dochartaigh, D., Ohshimo, S., Palazzo, F. S., Picard, C., Quek, B. H., Raitt, J., Ramaswamy, V. V., Scapigliati, Andrea, Shah, B. A., Stewart, C., Strand, M. L., Szyld, E., Thio, M., Topjian, A. A., Udaeta, E., Vaillancourt, C., Wetsch, W. A., Wigginton, J., Yamada, N. K., Yao, S., Zace, D., Zelop, C. M., Sandroni C. (ORCID:0000-0002-8878-2611), Scapigliati A. (ORCID:0000-0002-4044-2343), Wyckoff, M. H., Greif, R., Morley, P. T., Ng, K. -C., Olasveengen, T. M., Singletary, E. M., Soar, J., Cheng, A., Drennan, I. R., Liley, H. G., Scholefield, B. R., Smyth, M. A., Welsford, M., Zideman, D. A., Acworth, J., Aickin, R., Andersen, L. W., Atkins, D., Berry, D. C., Bhanji, F., Bierens, J., Borra, V., Bottiger, B. W., Bradley, R. N., Bray, J. E., Breckwoldt, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Couto, T. B., Dainty, K. N., Davis, P. G., De Almeida, M. F., De Caen, A. R., Deakin, C. D., Djarv, T., Donnino, M. W., Douma, M. J., Duff, J. P., Dunne, C. L., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Finn, J., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M., Kloeck, D. A., Kudenchuk, P. J., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y. (., Lockey, A. S., Maconochie, I. K., Madar, R. J., Malta Hansen, C., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Morgan, P., Morrison, L. J., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., O'Neill, B. J., Ong, Y. -K. G., Orkin, A. M., Paiva, E. F., Parr, M. J., Patocka, C., Pellegrino, J. L., Perkins, G. D., Perlman, J. M., Rabi, Y., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Skrifvars, M. B., Smith, C. M., Sugiura, T., Tijssen, J. A., Trevisanuto, D., Van De Voorde, P., Wang, T. -L., Weiner, G. M., Wyllie, J. P., Yang, C. -W., Yeung, J., Nolan, J. P., Berg, K. M., Burdick, M. C., Cartledge, S., Dawson, J. A., Elgohary, M. M., Ersdal, H. L., Finan, E., Flaatten, H. I., Flores, G. E., Fuerch, J., Garg, R., Gately, C., Goh, M., Halamek, L. P., Handley, A. J., Hatanaka, T., Hoover, A., Issa, M., Johnson, S., Kamlin, C. O., Ko, Y. -C., Kule, A., Leone, T. A., Mackenzie, E., Macneil, F., Montgomery, W., O'Dochartaigh, D., Ohshimo, S., Palazzo, F. S., Picard, C., Quek, B. H., Raitt, J., Ramaswamy, V. V., Scapigliati, Andrea, Shah, B. A., Stewart, C., Strand, M. L., Szyld, E., Thio, M., Topjian, A. A., Udaeta, E., Vaillancourt, C., Wetsch, W. A., Wigginton, J., Yamada, N. K., Yao, S., Zace, D., Zelop, C. M., Sandroni C. (ORCID:0000-0002-8878-2611), and Scapigliati A. (ORCID:0000-0002-4044-2343)

Abstract

This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. Topics covered by systematic reviews include cardiopulmonary resuscitation during transport; approach to resuscitation after drowning; passive ventilation; minimizing pauses during cardiopulmonary resuscitation; temperature management after cardiac arrest; use of diagnostic point-of-care ultrasound during cardiac arrest; use of vasopressin and corticosteroids during cardiac arrest; coronary angiography after cardiac arrest; public-access defibrillation devices for children; pediatric early warning systems; maintaining normal temperature immediately after birth; suctioning of amniotic fluid at birth; tactile stimulation for resuscitation immediately after birth; use of continuous positive airway pressure for respiratory distress at term birth; respiratory and heart rate monitoring in the delivery room; supraglottic airway use in neonates; prearrest prediction of in-hospital cardiac arrest mortality; basic life support training for likely rescuers of high-risk populations; effect of resuscitation team training; blended learning for life support training; training and recertification for resuscitation instructors; and recovery position for maintenance of breathing and prevention of cardiac arrest. Members from 6 task forces have assessed, discussed, and debated the quality of the evidence using Grading of Recommendations Assessment, Development, and Evaluation criteria and generated consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence-to-Decision Framework Highlights sections, and priority knowledge gaps for futu

Published
2022

38. Drugs for advanced life support

Author

Andersen, L. W., Nolan, J. P., Sandroni, Claudio, Sandroni C. (ORCID:0000-0002-8878-2611), Andersen, L. W., Nolan, J. P., Sandroni, Claudio, and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

Background. Treatment of patients with cardiac arrest includes basic and advanced life support (ALS) as outlined by the European Resuscitation Council. Until recently, there has been limited evidence to show that administration of these drugs improved patient outcomes. However, several randomized clinical trials testing various drugs during cardiac arrest have been published within the last years. Methods. We review these in this article. Results. Adrenergics have a small effect on survival after cardiac arrest, and survival rates in trials on ALS drugs are generally low. There is a continuing need for high-quality clinical trials to test new drugs to improve outcomes for patients with heart failure.

Published
2022

39. ImpACT+, a coping intervention to improve clinical outcomes for women living with HIV and sexual trauma in South Africa:study protocol for a randomized controlled trial

Author

Sikkema, K. J., Rabie, S., King, A., Watt, M. H., Mulawa, M. I., Andersen, L. S., Wilson, P. A., Marais, A., Ndwandwa, E., Majokweni, S., Orrell, C., Joska, J. A., Sikkema, K. J., Rabie, S., King, A., Watt, M. H., Mulawa, M. I., Andersen, L. S., Wilson, P. A., Marais, A., Ndwandwa, E., Majokweni, S., Orrell, C., and Joska, J. A.

Abstract

Background: Addressing sexual trauma in the context of HIV care is essential to improve clinical outcomes and mental health among women in South Africa. Women living with HIV (WLH) report disproportionately high levels of sexual trauma and have higher rates of posttraumatic stress disorder. Adherence to antiretroviral therapy (ART) may be difficult for traumatized women, as sexual trauma compounds the stress associated with managing HIV and is often comorbid with other mental health disorders, further compromising care engagement and adherence. ART initiation represents a unique window of opportunity for intervention to enhance motivation, increase care engagement, and address the negative effects of trauma on avoidant coping behaviors. Mental health interventions delivered by non-specialists in low- and middle-income countries have potential to treat depression, trauma, and effects of intimate partner violence among WLH. This study will examine the effectiveness of Improving AIDS Care after Trauma (ImpACT +), a task-shared, trauma-focused coping intervention, to promote viral suppression among WLH initiating ART in a South African clinic setting. Methods: This study will be conducted in Khayelitsha, a peri-urban settlement situated near Cape Town, South Africa. Using a hybrid type 1 effectiveness-implementation design, we will randomize 350 WLH initiating ART to the ImpACT + experimental condition or the control condition (three weekly sessions of adapted problem-solving therapy) to examine the effectiveness of ImpACT + on viral suppression, ART adherence, and the degree to which mental health outcomes mediate intervention effects. ImpACT + participants will receive six once-a-week coping intervention sessions and six monthly maintenance sessions over the follow-up period. We will conduct mental health and bio-behavioral assessments at baseline, 4, 8, and 12 months, with care engagement data extracted from medical records. We will explore scalability using the C

Published
2022

41. First-time anterior cruciate ligament injury in adolescent female elite athletes:a prospective cohort study to identify modifiable risk factors

Author

Zebis, M. K., Aagaard, P., Andersen, L. L., Hölmich, P., Clausen, M. B., Brandt, M., Husted, R. S., Lauridsen, H. B., Curtis, D. J., Bencke, J., Zebis, M. K., Aagaard, P., Andersen, L. L., Hölmich, P., Clausen, M. B., Brandt, M., Husted, R. S., Lauridsen, H. B., Curtis, D. J., and Bencke, J.

Abstract

Purpose: To identify modifiable biomechanical and neuromuscular anterior cruciate ligament (ACL) injury risk factors for first-time ACL injury in adolescent female elite football and team handball players. Methods: Adolescent female elite football and handball players with no previous ACL injury participated in the present study. At baseline, players were tested during side-cutting manoeuvres performed in a 3-dimensional motion analysis laboratory with concomitant electromyography (EMG) measurements. Maximal isometric lower limb muscle strength was assessed by handheld dynamometry. Players were prospectively followed for 2 years after baseline testing, and all magnetic resonance imaging (MRI) verified ACL injuries were registered. The effect of 16 risk factor candidates on the relative risk (RR) of ACL injury was estimated using Poisson regression analysis. Results: Ninety players (age 16.9 ± 1.2 years) were included in the analyses. Nine first-time ACL injuries (injury incidence 10.0% (95% confidence interval (CI) 5.4–18.6%)) were registered during the 2-year follow-up period. Four risk factor candidates were significantly associated with the risk of ACL injury: (1) hip flexion angle at initial contact (IC) [RR 0.56, 95% confidence interval (CI) 0.34–0.92], (2) internal knee rotation angle at IC [RR 1.13, 95% CI 1.08–1.19], (3) semitendinosus EMG activity 50 ms prior to IC [RR: 0.62, 95% CI 0.43–0.89], and (4) external hip rotator strength [RR: 0.77, 95% CI 0.66–0.89]. Conclusion: Four distinct ACL injury risk factors related to the side-cutting manoeuvre were identified in a population of adolescent female elite football and team handball players with no previous ACL injury. As ACL injury typically occur during side-cutting, intervention programmes to modify these risk factors pose a promising strategy for ACL injury prevention in adolescent female elite football and team handball. Level of evidence: II.

Published
2022

42. ERC-ESICM guidelines on temperature control after cardiac arrest in adults

Author

Sandroni, Claudio, Nolan, J. P., Andersen, L. W., Bottiger, B. W., Cariou, A., Cronberg, T., Friberg, H., Genbrugge, C., Lilja, G., Morley, P. T., Nikolaou, N., Olasveengen, T. M., Skrifvars, M. B., Taccone, F. S., Soar, J., Sandroni C. (ORCID:0000-0002-8878-2611), Sandroni, Claudio, Nolan, J. P., Andersen, L. W., Bottiger, B. W., Cariou, A., Cronberg, T., Friberg, H., Genbrugge, C., Lilja, G., Morley, P. T., Nikolaou, N., Olasveengen, T. M., Skrifvars, M. B., Taccone, F. S., Soar, J., and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

The aim of these guidelines is to provide evidence‐based guidance for temperature control in adults who are comatose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying cardiac rhythm. These guidelines replace the recommendations on temperature management after cardiac arrest included in the 2021 post-resuscitation care guidelines co-issued by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM). The guideline panel included thirteen international clinical experts who authored the 2021 ERC-ESICM guidelines and two methodologists who participated in the evidence review completed on behalf of the International Liaison Committee on Resuscitation (ILCOR) of whom ERC is a member society. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations. The panel provided suggestions on guideline implementation and identified priorities for future research. The certainty of evidence ranged from moderate to low. In patients who remain comatose after cardiac arrest, we recommend continuous monitoring of core temperature and actively preventing fever (defined as a temperature > 37.7 °C) for at least 72 h. There was insufficient evidence to recommend for or against temperature control at 32–36 °C or early cooling after cardiac arrest. We recommend not actively rewarming comatose patients with mild hypothermia after return of spontaneous circulation (ROSC) to achieve normothermia. We recommend not using prehospital cooling with rapid infusion of large volumes of cold intravenous fluids immediately after ROSC.

Published
2022

43. Importance of frequency and intensity of strength training for work ability among physical therapists

Author

Calatayud J, Morera A, Ezzatvar Y, Lopez-Bueno R, Andersen L, Cuenca-Martinez F, Suso-Marti L, Sanchis-Sanchez E, Lopez-Bueno L, and Casana J

Abstract

The aim of the study was to evaluate the association between frequency and intensity of strength training participation and work ability among physical therapists (PTs). The Work Ability Index questionnaire (WAI) and a questionnaire about participation in strength training during leisure time were administered to a sample of Spanish PTs. In addition, participants provided information on gender, age, body mass index, education, substance use, working experience and working hours per week. The odds for having excellent WAI (score 44-49) as a function of intensity or frequency of strength training participation were determined using binary logistic regression controlled for various confounders. Data from 981 PTs were analysed. High-intensity strength training (> 80% 1 RM) showed strong associations with excellent WAI (odds ratio = 9.7; 95% confidence interval, 2.9-31.6). In addition, performing strength training more than 3 times per week was associated with excellent WAI (odds ratio = 1.79; 95% confidence interval, 1.24-2.59), however, no significant associations were found with lower levels of frequency and intensities. High-intensity strength training 3 times per week is associated with excellent WAI among PTs. Training programs meeting these features may importantly contribute to maintain or improve WAI.

Published
2022

45. External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis

Author

Snell, K, Allotey, J, Smuk, M, Hooper, R, Chan, C, Ahmed, A, Chappell, L, Von Dadelszen, P, Green, M, Kenny, L, Khalil, A, Khan, K, Mol, B, Myers, J, Poston, L, Thilaganathan, B, Staff, A, Smith, G, Ganzevoort, W, Laivuori, H, Odibo, A, Arenas Ramirez, J, Kingdom, J, Daskalakis, G, Farrar, D, Baschat, A, Seed, P, Prefumo, F, da Silva Costa, F, Groen, H, Audibert, F, Masse, J, Skrastad, R, Salvesen, K, Haavaldsen, C, Nagata, C, Rumbold, A, Heinonen, S, Askie, L, Smits, L, Vinter, C, Magnus, P, Eero, K, Villa, P, Jenum, A, Andersen, L, Norman, J, Ohkuchi, A, Eskild, A, Bhattacharya, S, Mcauliffe, F, Galindo, A, Herraiz, I, Carbillon, L, Klipstein-Grobusch, K, Yeo, S, Browne, J, Moons, K, Riley, R, Thangaratinam, S, Vergani, P, Snell K. I. E., Allotey J., Smuk M., Hooper R., Chan C., Ahmed A., Chappell L. C., Von Dadelszen P., Green M., Kenny L., Khalil A., Khan K. S., Mol B. W., Myers J., Poston L., Thilaganathan B., Staff A. C., Smith G. C. S., Ganzevoort W., Laivuori H., Odibo A. O., Arenas Ramirez J., Kingdom J., Daskalakis G., Farrar D., Baschat A. A., Seed P. T., Prefumo F., da Silva Costa F., Groen H., Audibert F., Masse J., Skrastad R. B., Salvesen K. A., Haavaldsen C., Nagata C., Rumbold A. R., Heinonen S., Askie L. M., Smits L. J. M., Vinter C. A., Magnus P., Eero K., Villa P. M., Jenum A. K., Andersen L. B., Norman J. E., Ohkuchi A., Eskild A., Bhattacharya S., McAuliffe F. M., Galindo A., Herraiz I., Carbillon L., Klipstein-Grobusch K., Yeo S. A., Browne J. L., Moons K. G. M., Riley R. D., Thangaratinam S., Vergani P., Snell, K, Allotey, J, Smuk, M, Hooper, R, Chan, C, Ahmed, A, Chappell, L, Von Dadelszen, P, Green, M, Kenny, L, Khalil, A, Khan, K, Mol, B, Myers, J, Poston, L, Thilaganathan, B, Staff, A, Smith, G, Ganzevoort, W, Laivuori, H, Odibo, A, Arenas Ramirez, J, Kingdom, J, Daskalakis, G, Farrar, D, Baschat, A, Seed, P, Prefumo, F, da Silva Costa, F, Groen, H, Audibert, F, Masse, J, Skrastad, R, Salvesen, K, Haavaldsen, C, Nagata, C, Rumbold, A, Heinonen, S, Askie, L, Smits, L, Vinter, C, Magnus, P, Eero, K, Villa, P, Jenum, A, Andersen, L, Norman, J, Ohkuchi, A, Eskild, A, Bhattacharya, S, Mcauliffe, F, Galindo, A, Herraiz, I, Carbillon, L, Klipstein-Grobusch, K, Yeo, S, Browne, J, Moons, K, Riley, R, Thangaratinam, S, Vergani, P, Snell K. I. E., Allotey J., Smuk M., Hooper R., Chan C., Ahmed A., Chappell L. C., Von Dadelszen P., Green M., Kenny L., Khalil A., Khan K. S., Mol B. W., Myers J., Poston L., Thilaganathan B., Staff A. C., Smith G. C. S., Ganzevoort W., Laivuori H., Odibo A. O., Arenas Ramirez J., Kingdom J., Daskalakis G., Farrar D., Baschat A. A., Seed P. T., Prefumo F., da Silva Costa F., Groen H., Audibert F., Masse J., Skrastad R. B., Salvesen K. A., Haavaldsen C., Nagata C., Rumbold A. R., Heinonen S., Askie L. M., Smits L. J. M., Vinter C. A., Magnus P., Eero K., Villa P. M., Jenum A. K., Andersen L. B., Norman J. E., Ohkuchi A., Eskild A., Bhattacharya S., McAuliffe F. M., Galindo A., Herraiz I., Carbillon L., Klipstein-Grobusch K., Yeo S. A., Browne J. L., Moons K. G. M., Riley R. D., Thangaratinam S., and Vergani P.

Abstract

BACKGROUND: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk during pregnancy is required to plan management. Although there are many published prediction models for pre-eclampsia, few have been validated in external data. Our objective was to externally validate published prediction models for pre-eclampsia using individual participant data (IPD) from UK studies, to evaluate whether any of the models can accurately predict the condition when used within the UK healthcare setting. METHODS: IPD from 11 UK cohort studies (217,415 pregnant women) within the International Prediction of Pregnancy Complications (IPPIC) pre-eclampsia network contributed to external validation of published prediction models, identified by systematic review. Cohorts that measured all predictor variables in at least one of the identified models and reported pre-eclampsia as an outcome were included for validation. We reported the model predictive performance as discrimination (C-statistic), calibration (calibration plots, calibration slope, calibration-in-the-large), and net benefit. Performance measures were estimated separately in each available study and then, where possible, combined across studies in a random-effects meta-analysis. RESULTS: Of 131 published models, 67 provided the full model equation and 24 could be validated in 11 UK cohorts. Most of the models showed modest discrimination with summary C-statistics between 0.6 and 0.7. The calibration of the predicted compared to observed risk was generally poor for most models with observed calibration slopes less than 1, indicating that predictions were generally too extreme, although confidence intervals were wide. There was large between-study heterogeneity in each model's calibration-in-the-large, suggesting poor calibration of the predicted overall risk across populations. In a subset of models, the net benefit of using the models to inform clinical decisions

Published
2020

46. An alternative and conserved cell wall enzyme that can substitute for the lipid II synthase MurG

Author

Zhang, L., Ramijan, K., Carrion Bravo, V.J., Aart, L.T. van der, Willemse, J.J., Wezel, G.P. van, Claessen, D., S{ø}gaard-Andersen L, and S{ø}gaard-Andersen L

Subjects
morphology switch, peptidoglycan, N-Acetylglucosaminyltransferases, Microbiology, cell wall biosynthesis, Cell wall, MurG, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Cell Wall, Virology, Gene cluster, Peptide sequence, 030304 developmental biology, L-form, 0303 health sciences, CRISPR interference, ATP synthase, biology, Lipid II, 030306 microbiology, Streptomyces coelicolor, biology.organism_classification, Lipid Metabolism, Lipids, QR1-502, Actinobacteria, chemistry, Biochemistry, biology.protein, lipids (amino acids, peptides, and proteins), Peptidoglycan, Research Article, Bacterial Outer Membrane Proteins
Abstract

Almost all bacteria are surrounded by a cell wall, which protects cells from environmental harm. Formation of the cell wall requires the precursor molecule lipid II, which in bacteria is universally synthesized by the conserved and essential lipid II synthase MurG., The cell wall is a stress-bearing structure and a unifying trait in bacteria. Without exception, synthesis of the cell wall involves formation of the precursor molecule lipid II by the activity of the essential biosynthetic enzyme MurG, which is encoded in the division and cell wall synthesis (dcw) gene cluster. Here, we present the discovery of a cell wall enzyme that can substitute for MurG. A mutant of Kitasatospora viridifaciens lacking a significant part of the dcw cluster, including murG, surprisingly produced lipid II and wild-type peptidoglycan. Genomic analysis identified a distant murG homologue, which encodes a putative enzyme that shares only around 31% amino acid sequence identity with MurG. We show that this enzyme can replace the canonical MurG, and we therefore designated it MglA. Orthologues of mglA are present in 38% of all genomes of Kitasatospora and members of the sister genus Streptomyces. CRISPR interference experiments showed that K. viridifaciens mglA can also functionally replace murG in Streptomyces coelicolor, thus validating its bioactivity and demonstrating that it is active in multiple genera. All together, these results identify MglA as a bona fide lipid II synthase, thus demonstrating plasticity in cell wall synthesis.

Published
2021

47. Corrigendum to 'Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women' [Diab. Res. Clin. Pract. 168 (2020) 108378](S0168822720306318)(10.1016/j.diabres.2020.108378)

Author

Immanuel, J., Simmons, D., Desoye, G., Corcoy, R., Adelantado, J. M., Devlieger, R., Lapolla, A., Dalfra, M. G., Bertolotto, A., Harreiter, J., Wender-Ozegowska, E., Zawiejska, A., Dunne, F. P., Damm, P., Mathiesen, E. R., Jensen, D. M., Andersen, L. L. T., Hill, D. J., Jelsma, J. G. M., Snoek, F. J., Scharnagl, H., Galjaard, S., Kautzky-Willer, A., VAN Poppel, M. N. M., Public and occupational health, Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), and APH - Quality of Care

Abstract

The authors regret that a few lines in Tables 1 and 2 were formatted incorrectly in the published version of the article with numbers all appearing in one line instead of being in separate lines. The correctly formatted tables are shown below. The authors would like to apologise for any inconvenience caused.

Published
2021

49. Sugar-sweetened beverages consumption in relation to changes in body fatness over 6 and 12 years among 9-year-old children: the European Youth Heart Study

Author

Zheng, M., Rangan, A., Olsen, N.J., Andersen, L. Bo, Wedderkopp, N., Kristensen, P., Grontved, A., Ried-Larsen, M., Lempert, S.M., Allman-Farinelli, M., and Heitmann, B.L.

Subjects
Physiological aspects, Research, Health aspects, Child health -- Research, Medical research, Adipose tissue -- Physiological aspects -- Health aspects, Beverages -- Health aspects, Medicine, Experimental, Adipose tissues -- Physiological aspects -- Health aspects, Children -- Health aspects
Abstract

INTRODUCTION In recent years, the consumption of sugar-sweetened beverages (SSB) has steadily increased across the globe. (1) Studies have shown that high SSB consumption is linked with obesity in children [...], BACKGROUND/OBJECTIVES: In parallel with the obesity epidemic, consumption of sugar-sweetened beverages (SSB) has risen over the same period. Our aim was to investigate associations between the consumption of SSB in childhood and adolescence with subsequent changes in body fatness in early adulthood. SUBJECTS/METHODS: A longitudinal study of 9-year-old children (n = 283) enrolled in the Danish part of the European Youth Heart Study with a 6-year and 12-year follow-up. Data were collected at ages 9, 15 and 21 years. Multivariate regression analyses with adjustment for potential confounders were used to evaluate the effect of SSB consumption at 9 and 15 years and change in SSB consumption from 9-15 years on subsequent change in body fatness until 21 years. RESULTS: Subjects who consumed more than one serve of SSB daily at age 15 years had larger increases in body mass index (BMI) (β = 0.92, P = 0.046) and waist circumference (WC) (β = 2.69, P = 0.04) compared to non-consumers over the subsequent 6 years. In addition, subjects who increased their SSB consumption from age 9-15 years also had larger increases in BMI (β = 0.91, P = 0.09) and WC (β = 2.72, P = 0.04) from 15-21 years, compared to those who reported no change in consumption. No significant association was observed from 9-21 years. CONCLUSION: This study provides new evidence that SSB consumption in adolescence and changes in SSB consumption from childhood to adolescence are both significant predictors of change in body fatness later in early adulthood. European Journal of Clinical Nutrition (2014) 68, 77-83; doi: 10.1038/ejcn.2013.243; published online 27 November 2013 Keywords: sugar sweetened beverages; body fatness; insulin sensitivity

Published
2014
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50. Interaction between rs10830962 polymorphism in MTNR1B and lifestyle intervention on maternal and neonatal outcomes: secondary analyses of the DALI lifestyle randomized controlled trial

Author

Van Poppel, M. N. M., Corcoy, R., Hill, D., Simmons, D., Mendizabal, L., Zulueta, M., Simon, L., Desoye, G., Adelantado Perez, J. M., Kautzky-Willer, A., Harreiter, J., Damm, P., Mathiesen, E., Jensen, D. M., Andersen, L. L. T., Dunne, F., Lapolla, A., Dalfra, M. G., Bertolotto, A., Van Poppel, M., Jelsma, J. G. M., Snoek, F. J., Galjaard, S., Wender-Ozegowska, E., Zawiejska, A., Devlieger, R., Public and occupational health, Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), APH - Quality of Care, and Medical Psychology

Subjects
Lifestyle intervention, Blood Glucose, Leptin, medicine.medical_treatment, Medicine (miscellaneous), law.invention, Randomized controlled trial, law, Pregnancy, Insulin, Gestational diabetes, Melatonin, Nutrition and Dietetics, C-Peptide, Diabetes, Pregnancy Outcome, Prenatal Care, Insulin sensitivity, Fetal Blood, Gestational Weight Gain, Cord blood, Gestational, Female, medicine.symptom, Diet, Healthy, Receptor, Adult, medicine.medical_specialty, Genotype, Melatonin receptor 1B, Polymorphism, Alleles, Diabetes, Gestational, Exercise, Humans, Infant, Newborn, Insulin Resistance, Receptor, Melatonin, MT2, Life Style, Polymorphism, Genetic, Insulin resistance, Genetic, Internal medicine, medicine, Healthy, business.industry, MT2, Infant, medicine.disease, Newborn, Diet, business, Weight gain
Abstract

Background: Interactions between polymorphisms of the melatonin receptor 1B (MTNR1B) gene and lifestyle intervention for gestational diabetes have been described. Whether these are specific for physical activity or the healthy eating intervention is unknown. Objectives: The aim was to assess the interaction between MTNR1B rs10830962 and rs10830963 polymorphisms and lifestyle interventions during pregnancy. Methods: Women with a BMI (in kg/m2) of ≥29 (n = 436) received counseling on healthy eating (HE), physical activity (PA), or both. The control group received usual care. This secondary analysis had a factorial design with comparison of HE compared with no HE and PA compared with no PA. Maternal outcomes at 24-28 wk were gestational weight gain (GWG), maternal fasting glucose, insulin, insulin resistance (HOMA-IR), disposition index, and development of GDM. Neonatal outcomes were cord blood leptin and C-peptide and estimated neonatal fat percentage. The interaction between receiving either the HE or PA intervention and genotypes of both rs10830962 and rs10830963 was assessed using multilevel regression analysis. Results: GDM risk was increased in women homozygous for the G allele of rs10830962 (OR: 2.60; 95% CI: 1.34, 5.06) or rs10830963 (OR: 2.83; 95% CI: 1.24, 6.47). Significant interactions between rs10830962 and interventions were found: in women homozygous for the G allele but not in the other genotypes, the PA intervention reduced maternal fasting insulin (β: -0.16; 95% CI: -0.33, 0.02; P = 0.08) and HOMA-IR (β: -0.17; 95% CI: -0.35, 0.01; P = 0.06), and reduced cord blood leptin (β: -0.84; 95% CI: -1.42, -0.25; P = 0.01) and C-peptide (β: -0.62; 95% CI: -1.07, -0.17; P = 0.01). In heterozygous women, the HE intervention had no effect, whereas in women homozygous for the C allele, HE intervention reduced GWG (β: -1.6 kg; 95% CI: -2.4, -0.8 kg). No interactions were found. Conclusions: In women homozygous for the risk allele of MTNR1B rs10830962, GDM risk was increased and PA intervention might be more beneficial than HE intervention for reducing maternal insulin resistance, cord blood C-peptide, and cord blood leptin.

Published
2021
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