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2. PMP22 overexpression causes dysmyelination in mice

Author

Robaglia-Schlupp, A., Pizant, J., Norreel, J.-C., Passage, E., Sabéran-Djoneidi, D., Ansaldi, J.-L., Vinay, L., Figarella-Branger, D., Lévy, N., Clarac, F., Cau, P., Pellissier, J.-F., and Fontés, M.

Published
2002

3. Oral Communication Abstracts

Author

Jumeau, C, Rupin, A, Villeneuve, N, Mougenot, N, Ansaldi, J, Alessi, Mc, Hatem, S, David-Dufilho, M, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), SERVIER, Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut de Recherche International Servier - Grant number 2012/0374

Subjects
Pharmacology, business.industry, [SDV]Life Sciences [q-bio], CCR3, 030226 pharmacology & pharmacy, Blockade, 03 medical and health sciences, [SPI]Engineering Sciences [physics], 0302 clinical medicine, Medicine, Pharmacology (medical), business, 030217 neurology & neurosurgery, Collagen-induced arthritis
Published
2016

4. Fish oil supplementation prevents diabetes-induced nerve conduction velocity and neuroanatomical changes in rats.

Author

Gerbi, Alain, Maixent, Jean-Michel, Gerbi, A, Maixent, J M, Ansaldi, J L, Pierlovisi, M, Coste, T, Pelissier, J F, Vague, P, and Raccah, D

Subjects
FISH oils, SCIATIC nerve, PHYSIOLOGY, ADENOSINE triphosphatase, ANIMAL experimentation, COMPARATIVE studies, DIABETES, DIETARY supplements, RESEARCH methodology, MEDICAL cooperation, NEURAL conduction, NEURONS, RATS, RESEARCH, TIME, EVALUATION research
Abstract

Diabetic neuropathy has been associated with a decrease in nerve conduction velocity, Na,K-ATPase activity and characteristic histological damage of the sciatic nerve. The aim of this study was to evaluate the potential effect of a dietary supplementation with fish oil [(n-3) fatty acids] on the sciatic nerve of diabetic rats. Diabetes was induced by intravenous streptozotocin injection. Diabetic animals (n = 20) were fed a nonpurified diet supplemented with either olive oil (DO) or fish oil (DM), and control animals (n = 10) were fed a nonpurified diet supplemented with olive oil at a daily dose of 0.5 g/kg by gavage for 8 wk. Nerves were characterized by their conduction velocity, morphometric analysis and membrane Na, K-ATPase activity. Nerve conduction velocity, as well as Na,K-ATPase activity, was improved by fish oil treatment. A correlation was found between these two variables (R = 0.999, P < 0.05). Moreover, a preventive effect of fish oil was observed on nerve histological damage [endoneurial edema, axonal degeneration (by 10-15%) with demyelination]. Moreover, the normal bimodal distribution of the internal diameter of myelinated fibers was absent in the DO group and was restored in the DM group. These data suggest that fish oil therapy may be effective in the prevention of diabetic neuropathy. [ABSTRACT FROM AUTHOR]

Published
1999
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5. Morphological polarization of human polymorphonuclear leucocytes in response to three different chemoattractants: an effector response independent of calcium rise and tyrosine kinases.

Author

Lepidi, H, Zaffran, Y, Ansaldi, J L, Mege, J L, and Capo, C

Abstract

Chemoattractants such as interleukin-8, C5a and N-formylmethionyl-leucyl-phenylalanine induce a cytosolic calcium rise involved in triggering the secretory functions of human polymorphonuclear leucocytes. We studied the possible role of calcium rise in membrane ruffling, actin polymerization, filamentous actin distribution, and morphological polarization, which are all events contributing to chemotaxis. Membrane ruffling was assessed by right-angle light-scatter changes, the cellular content of polymerized actin by fluorescence of bodipy phallacidin, the intracellular distribution of filamentous actin by fluorescence microscopy and image digitization, and morphological polarization by scanning electron microscopy. Pretreatment of polymorphonuclear leucocytes with 50 microM BAPTA/AM, an intracellular calcium chelator, lowered the basal level in cell calcium and inhibited the transient calcium rise stimulated by 2 nM interleukin-8, 2 nM C5a, and 10 nM N-formylmethionyl-leucyl-phenylalanine. However, BAPTA pretreatment of polymorphonuclear leucocytes did not modify membrane ruffling, actin polymerization, filamentous actin distribution, and morphological polarization stimulated by chemoattractants. Downstream effectors may be protein tyrosine kinases. However, the tyrosine kinase inhibitor tyrphostin did not affect the cytoskeletal characteristics elicited by chemoattractants. Taken together, our results suggest that the transductional pathway leading to cytoskeleton organization and morphological polarization of polymorphonuclear leucocytes is different from that leading to secretion.

Published
1995

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