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Introduction Renal scintigraphy (RS) is occasionally performed to assess the risk of persistent renal failure (PRF) in patients with acute kidney disease (AKD). However, its diagnostic performance has never been assessed. Methods We identified all patients with AKD for whom RS was performed in our institution between 2010 and 2017. PRF was defined as persistently low ( Results Among 97 patients included, 57 (59%) fulfilled the criteria for PRF. The PRF score was able to predict PRF with an AUC of 0.63. Similarly, the accumulation index and accumulation slope respective AUCs were 0.64 and 0.63. None of these parameters were able to improve the performance of the clinical model. Among new parameters, the 3rd/2nd minute activity ratio and 3rd/2nd minute activity slope had fair diagnostic performance (AUC 0.72 and 0.74, respectively) and improved the performance of the clinical model. Results were confirmed in sensitivity analyses. Conclusion Conventional renal scintigraphy can identify patients at high risk of PRF with a high specificity but a low sensitivity. New parameters, with comparable diagnostic abilities can be obtained within three minutes of injection. Graphical abstract

IntroductionPrevious studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity of AKI after surgery. However, the effects of the care bundle in broader population of patients undergoing surgery require confirmation.Methods and analysisThe BigpAK-2 trial is an international, randomised, controlled, multicentre trial. The trial aims to enrol 1302 patients undergoing major surgery who are subsequently admitted to the intensive care or high dependency unit and are at high-risk for postoperative AKI as identified by urinary biomarkers (tissue inhibitor of metalloproteinases 2*insulin like growth factor binding protein 7 (TIMP-2)*IGFBP7)). Eligible patients will be randomised to receive either standard of care (control) or a KDIGO-based AKI care bundle (intervention). The primary endpoint is the incidence of moderate or severe AKI (stage 2 or 3) within 72 hours after surgery, according to the KDIGO 2012 criteria. Secondary endpoints include adherence to the KDIGO care bundle, occurrence and severity of any stage of AKI, change in biomarker values during 12 hours after initial measurement of (TIMP-2)*(IGFBP7), number of free days of mechanical ventilation and vasopressors, need for renal replacement therapy (RRT), duration of RRT, renal recovery, 30-day and 60-day mortality, intensive care unit length-of-stay and hospital length-of-stay and major adverse kidney events. An add-on study will investigate blood and urine samples from recruited patients for immunological functions and kidney damage.Ethics and disseminationThe BigpAK-2 trial was approved by the Ethics Committee of the Medical Faculty of the University of Münster and subsequently by the corresponding Ethics Committee of the participating sites. A study amendment was approved subsequently. In the UK, the trial was adopted as an NIHR portfolio study. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and will guide patient care and further research.Trial registration numberNCT04647396.

HBM4EU chromates study team: Kukka Aimonen8, Guillaume Antoine1, Rob Anzion9, Manuella Burgart1, Andrea Cattaneo11, Domenico M. Cavallo11, Alcina Costa12, Giuseppe De Palma13, Flavien Denis1, Giovanni Forte3, Angela Gambelunghe14, Ogier Hanser1, Carina Ladeira15, Elisabeth Leese16, Risto Lehtinen8, Henriqueta Louro7 Piero Lovreglio17, Nicole Majery18, Philippe Marsan1, Mathieu Melczer1, Armandida Miranda12, Edna Ribeiro15, Françoise Schaefers4, Marta Senofonte3, Filomena Seuanes12, Maurice van Dael9, Riitta Velin8 1French National Research and Safety Institute, Vandoeuvre-les-Nancy, France 2Department of Public Health, University of Naples Federico II, Naples, Italy 3 Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy 4Department of Health Protection, Laboratoire National de Santé (LNS), Dudelange, Luxembourg 5Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven (University of Leuven), Kapucijnenvoer 35, 3000, Leuven, Belgium 6Nofer Institute of Occupational Medicine, Lodz, Poland 7National Institute of Health Dr. Ricardo Jorge, Department of Human Genetics and Environmental Health Lisbon, Portugal 8Finnish Institute of Occupational Health, Helsinki, Finland 9Radboud Institute for Health Sciences, Radboudumc, Nijmegen, the Netherlands 10NOVA NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, 1600–560 Lisbon, Portugal; Comprehensive Health Research Center (CHRC), 1169–056 Lisbon, Portugal. 11Department of Science and High Technology, University of Insubria, Como, Italy 12National Institute of Health Dr. Ricardo Jorge, Department of Health Promotion, Lisbon, Portugal 13Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy 14Departement of Medicine and Surgery, University of Perugia, Perugia, Italy 15H&TRC- Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa; Comprehensive Health Research Center (CHRC), 1169–056 Lisbon, Portugal 16Health and Safety Executive, Buxton, SK17 9JN, United Kingdom 17Interdisciplinary Departement of Medecine, University of Bari, Bari, Italy 18Service de Santé Au Travail Multisectoriel (STM), Luxembourg Occupational exposures to hexavalent Chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful when more specific infor-mation on systemic and intracellular bioavailability is necessary. To this aim, concentrations of Cr in red blood cells (RBC-Cr) and in plasma (P–Cr) were analyzed in 345 Cr(VI) exposed workers and 175 controls to understand how these biomarkers may be affected by variable levels of exposure and job procedures. Compared to controls, significantly higher RBC-Cr levels were observed in bath plating and paint application workers, but not in welders, while all the 3 groups had significantly greater P–Cr concentrations. RBC-Cr and P–Cr in chrome platers showed a high correlation with Cr(VI) in inhalable dust, outside respiratory protective equipment (RPE), while such correlation could not be determined in welders. In platers, the use of RPE had a significant impact on the relationship between blood biomarkers and Cr(VI) in inhalable and respirable dust. Low correlations between P–Cr and RBC-Cr may reflect a difference in kinetics. This study showed that Cr-blood-based biomarkers can provide information on how workplace exposure translates into systemic availability of Cr(III) (extracellular, P–Cr) and Cr(VI) (intracellular, RBC-Cr). Further studies are needed to fully appreciate their use in an occupational health and safety context. Highlights: Suitability of blood biomarkers was evaluated to assess occupational Cr(VI)exposure; Bath platers and painters had higher Red Blood Cells-Cr levels compared to controls; Bath platers, painters and welders had higher plasma-Cr levels compared to controls; Red Blood Cells- and Plasma-Cr were highly correlated with inhalable Cr(VI) in platers; Blood-Cr biomarkers can provide information on systemic and intracellular availability. This work has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means. info:eu-repo/semantics/publishedVersion

Situation-Background-Assessment-Recommendation (SBAR) is a tool for structuring communication between healthcare professionals. SBAR reduces medical errors, however few studies have evaluated its quality in real practice.To describe the quality of SBAR utilization by intensive care unit (ICU) nurses during phone conversations with physicians. To assess the influence of nurses' training, professional experience, and call circumstances on this quality.This observational study was conducted in the adult ICU of a university hospital in French speaking Switzerland. All consecutive telephone calls from nurses to physicians during a calendar month, were recorded. Those related to a change in patients' clinical status were selected and analysed. The quality of SBAR utilization was assessed using a pre-defined analysis grid. Scores ranged from 0 (worst quality) to 100% (best quality). Nurses' sociodemographics and training record were collected. Multiple regression was used to assess determinants of SBAR quality including nurses characteristics and level of training.We analysed 290 phone calls, made by 99 nurses. The median SBAR quality score was 41% (interquartile range [IQR] 33-48). Quality scores varied across the four items of SBAR: Situation 88% (81-94), Background 17% (6-27), Assessment 17% (0-33), and Recommendation 33% (17-40). Factors independently associated with higher SBAR quality were age (-0.66%, p = .002, 95% CI [-1.07; -0.25]), primary language other than French (-8.40%, p = .017, 95% CI [-15.29; -1.51]), lack of ICU expertise (-9.25%, p = .013, 95% CI [-16.5;1-1.99]), and SBAR training in pre-graduate nursing education (+11.53%, p = .028, 95% CI [1.27; 22.79]).The quality of SBAR utilization remains low in ICU clinical practice. Pre- and post-graduate training seem to improve its quality.Pre-graduate mandatory training associated with multiple repetitions could improve nurses' SBAR utilization. Training using the SBAR tool should be combined with the development of nursing skills in assessment and clinical judgment.

Madelung's deformity is a rare congenital condition of the wrist that can cause pain, aesthetic concerns, reduced range of motion and grip strength. Currently, there is no consensus on the optimal age for surgery or whether operative procedures can be isolated or combined depending on the extent of the deformity. The main objective of our study was to analyze the postoperative functional clinical results at a minimum of 3-years follow-up in patients operated on for Madelung's deformity. The secondary objectives were (1) comparison of preoperative and postoperative radiographic parameters, and (2) to assess whether certain preoperative radiographic parameters influence the choice of surgical procedure.The surgery offered at our center achieves clinical and radiological result necessary for long-term activities of daily living, and varies according to the severity of the distal radial deformity.We carried out a retrospective observational monocentric study including patients operated on between 2004 and 2016. Clinical (VAS, mobility), functional (PRWE score), and radiographic assessments were performed before and after the last follow-up.The study included 11 patients (12 wrists) with a mean age of 17±7.3 years and a mean follow-up of 8.1 years (4-12.3). The mean VAS was 2.3 (0-6) and the mean PRWE score was 37 (0-108). The mean flexion-extension arc was 134° and that of pronation and supination was 142°. The mean grip strength was 25.8±11.8kg. Four out of 6 radiographic criteria were significantly improved. An isolated radial osteotomy or combined radioulnar osteotomy was performed when the sagittal radial tilt was greater than 30° and protrusion of the lunate greater than 5mm, otherwise below these values, an isolated ulnar osteotomy was performed.Our center offers surgical management of Madelung's deformity by osteotomy which improves the majority of postoperative radiographic parameters and gives satisfactory clinical and radiographic results after a mean follow-up of 8.1 years. The surgery is influenced by the severity of the distal radial deformity, including protrusion of the lunate and sagittal radial tilt.IV, Retrospective study.

This volume is the first book-length presentation of the relatively newly established grammatical category of Associated Motion. It provides a framework for understanding a grammatical phenomenon which, though present in many languages, has gone unrecognised until recently. Previously known mainly from languages of Australia and South America, grammatical AM marking has now been identified in languages from most parts of the world (except Europe) and is becoming an important topic of linguistic typology. The 22 chapters provide a thorough introduction to the subject, discussion of the relation between AM and related grammatical concepts, detailed descriptions of AM in a wide range of the world’s languages, and surveys of AM in particular language families and areas. All of the studies are richly illustrated by means of approximately 2000) example sentences.

Pictures and video stimuli help investigate specific semantic domains and/or grammatical categories. Such stimuli not only help to collect more occurrences of a given (possibly rare) morpheme in a semi-spontaneous setting, but also allow the study of variation across speakers and diversity across languages. The paper describes a stimulus in the form of a storybook, A Hunting Story, specifically conceived to elicit associated motion (AM) morphemes in Ese Ejja, an Amazonian language with a complex system of 14 such morphemes. The pictures of the storybook therefore represent an Amazonian setting, and the scenario incorporates the main parameters established in the AM literature (such as path/directionality, temporal relation, moving argument), as well as less frequent ones (such as aspectual realization). The paper describes the data collected from 14 speakers of Ese Ejja as well as data collected with the same stimulus in other languages, including languages with no morphological AM system.

Additional file 1: Table S1. Demographics of survey responders. Figure S1. VAS (visual analog scale). Figure S2. Study flow chart. Figure S3. Differences between observed and predicted (French speaking Swiss reference population).

IMPORTANCE: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival. Administration of the detoxifying enzyme alkaline phosphatase may improve kidney function and survival. OBJECTIVE: To determine the optimal therapeutic dose, effect on kidney function, and adverse effects of a human recombinant alkaline phosphatase in patients who are critically ill with sepsis-associated AKI. DESIGN, SETTING, AND PARTICIPANTS: The STOP-AKI trial was an international (53 recruiting sites), randomized, double-blind, placebo-controlled, dose-finding, adaptive phase 2a/2b study in 301 adult patients admitted to the intensive care unit with a diagnosis of sepsis and AKI. Patients were enrolled between December 2014 and May 2017, and follow-up was conducted for 90 days. The final date of follow-up was August 14, 2017. INTERVENTIONS: In the intention-to-treat analysis, in part 1 of the trial, patients were randomized to receive recombinant alkaline phosphatase in a dosage of 0.4 mg/kg (n = 31), 0.8 mg/kg (n = 32), or 1.6 mg/kg (n = 29) or placebo (n = 30), once daily for 3 days, to establish the optimal dose. The optimal dose was identified as 1.6 mg/kg based on modeling approaches and adverse events. In part 2, 1.6 mg/kg (n = 82) was compared with placebo (n = 86). MAIN OUTCOMES AND MEASURES: The primary end point was the time-corrected area under the curve of the endogenous creatinine clearance for days 1 through 7, divided by 7 to provide a mean daily creatinine clearance (AUC(1-7) ECC). Incidence of fatal and nonfatal (serious) adverse events ([S]AEs) was also determined. RESULTS: Overall, 301 patients were enrolled (men, 70.7%; median age, 67 years [interquartile range {IQR}, 59-73]). From day 1 to day 7, median ECC increased from 26.0 mL/min (IQR, 8.8 to 59.5) to 65.4 mL/min (IQR, 26.7 to 115.4) in the recombinant alkaline phosphatase 1.6-mg/kg group vs from 35.9 mL/min (IQR, 12.2 to 82.9) to 61.9 mL/min (IQR, 22.7 to 115.2) in the placebo group (absolute difference, 9.5 mL/min [95% CI, −23.9 to 25.5]; P = .47). Fatal adverse events occurred in 26.3% of patients in the 0.4-mg/kg recombinant alkaline phosphatase group; 17.1% in the 0.8-mg/kg group, 17.4% in the 1.6-mg/kg group, and 29.5% in the placebo group. Rates of nonfatal SAEs were 21.0% for the 0.4-mg/kg recombinant alkaline phosphatase group, 14.3% for the 0.8-mg/kg group, 25.7% for the 1.6-mg/kg group, and 20.5% for the placebo group. CONCLUSIONS AND RELEVANCE: Among patients who were critically ill with sepsis-associated acute kidney injury, human recombinant alkaline phosphatase compared with placebo did not significantly improve short-term kidney function. Further research is necessary to assess other clinical outcomes. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02182440

International audience; This article investigates the recently recognized concept of ASSOCIATED MOTION in 66 South American languages located on the western fringes of the Amazonian basin. In that region, associated motion is a widespread and particularly complex phenomenon. It is instantiated by verbal affixes in 44 languages, of which 22 display complex systems of multiple affixes. Correlations are noticed between the degree of complexity of the systems and the semantic content of the markers. Two implicational scales are proposed: (i) motion of the subject > motion of the object and (ii) prior motion > concurrent motion > subsequent motion. Correlations are also observed between the types of systems and their geographical distribution. These are taken as evidence that diffusion must have played an important role in spreading associated motion in this region and shaping its particular semantic make-up in the different languages.

The five Tacanan languages (Amazonian Bolivia and Peru)—Araona, Cavinena, Ese Ejja, Reyesano, and Tacana—have a conspicuously similar verbal suffix -ta (or -ka in one dialect of Ese Ejja). Depending on the language and the transitivity of the verb stem it attaches to, this suffix is used either to refer to a third-person plural S argument or a third-person singular or plural A argument, or to mark a passive derivation. In this paper, I argue that the suffixes are all historically related and that they come from a single source: a third-person plural suffix *-ta. I also suggest that this marker could have originated in a third-person plural independent pronoun that I reconstruct as **tuna.

Cet article analyse et discute des apports méthodologiques de l’ethnographie pour les études consacrées aux sports. Il présente les étapes les plus ordinairement franchies par les chercheurs et leurs significations dans la relation d’enquête ainsi que les difficultés rencontrées dans les publications scientifiques. En observant les sportifs, l’ethnographe compose une trame narrative des faits où il traque le particulier pour extraire le sens de ces activités. Ses travaux contribuent à renouveler l’approche de ces objets. L’implication du chercheur auprès des pratiquants imposerait de recourir à des méthodes spécifiques pour dépasser l’étude de cas (mode innovant de recueil de données, comparaisons). This paper analyzes and discusses the methodological contributions of ethnography for studies of sports. It presents the steps most commonly crossed by researchers and their meanings in relation to investigation and the difficulties encountered in the scientific literature. Observing the sport, the ethnographer composed a narrative of facts where the individual tracks to extract the meaning of these activities. His work contributed to renew the approach of these objects. The involvement of the researcher to require practitioners to use specific methods to overcome the case study (mode of data collection, comparison). Este artigo analisa e discute as contribuições metodológicas da etnografia para o estudo do desporto. Apresenta os passos geralmente mais encontrados pelos investigadores e os seus significados em relação à pesquisa e às dificuldades encontradas na literatura científica. Ao observar os desportistas, o etnógrafo compõe uma narrativa de factos onde acompanha o significado dessas atividades. O seu trabalho contribui para renovar a abordagem desses objectos. O envolvimento do investigador com os profissionais exige o uso de métodos específicos para superar o estudo de caso (modo inovador de recolha de dados, comparações). info:eu-repo/semantics/publishedVersion

Cavinena, an ergative language spoken in Amazonian Bolivia, has a very intriguing pronominal system where, notably, a pronoun coding a transitive subject can either have a full “ergative” form or a reduced form that makes it look like an “absolutive” pronoun (used to code an intransitive subject or a transitive object). Camp (1985) describes the system as an instance of “split ergativity” conditioned by the difference between main and subordinate clause, the mood/polarity of the clause, the constituent order, and a person hierarchy. The phenomenon of split ergative systems was first discussed in the 1970s (by Dixon 1972; 1979, Silverstein 1976, and Comrie 1978, among others) and this certainly influenced Camp’s “split ergative” analysis. The goal of this paper is to reevaluate Camp’s analysis in the light of new findings about the coding of grammatical functions in this language. It is shown that the peculiarities of the Cavinena pronominal system can be accounted for in a more elegant explanatory and typ...

Transparent laminates are widely used for body armor, goggles, windows and windshields. Improved understanding of their deformations under impact loading and of energy dissipation mechanisms is needed for minimizing their weight. This requires verified and robust computational algorithms and validated mathematical models of the problem. Here we have developed a mathematical model for analyzing the impact response of transparent laminates made of polymeric materials and implemented it in the finite element software LS-DYNA. Materials considered are polymethylmethacrylate (PMMA), polycarbonate (PC) and adhesives. The PMMA and the PC are modeled as elasto-thermo-visco-plastic and adhesives as viscoelastic. Their failure criteria are stated and simulated by the element deletion technique. Values of material parameters of the PMMA and the PC are taken from the literature, and those of adhesives determined from their test data. Constitutive equations are implemented as user-defined subroutines in LS-DYNA which are verified by comparing numerical and analytical solutions of several initial-boundary-value problems. Delamination at interfaces is simulated by using a bilinear traction separation law and the cohesive zone model. We present mathematical and computational models in chapter one and validate them by comparing their predictions with test findings for impacts of monolithic and laminated plates. The principal source of energy dissipation of impacted PMMA/adhesive/PC laminates is plastic deformations of the PC. In chapter two we analyze impact resistance of doubly curved monolithic PC panels and delineate the effect of curvature on the energy dissipated. It is found that the improved performance of curved panels is due to the decrease in the magnitude of stresses near the center of impact. In chapter three we propose constitutive relations for finite deformations of adhesives and find values of material parameters by considering test data for five portions of cyclic loading. Even though these values give different amounts of energy dissipated in the adhesive, their effect on the computed impact response of PMMA/adhesive/PC laminates is found to be minimal. In chapter four we conduct sensitivity analysis to identify critical parameters that significantly affect the energy dissipated. The genetic algorithm is used to optimally design a transparent laminate in chapter five. Ph. D.

All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is incomplete. In this study, we used Bovine Herpesvirus 4 (BoHV-4) to determine how its gp350 homolog - gp180 - contributes to virus replication and neutralization. A lack of gp180 had no impact on the establishment and maintenance of BoHV-4 latency, but markedly sensitized virions to neutralization by immune sera. Antibody had greater access to gB, gH and gL on gp180-deficient virions, including neutralization epitopes. Gp180 appears to be highly O-glycosylated, and removing O-linked glycans from virions also sensitized them to neutralization. It therefore appeared that gp180 provides part of a glycan shield for otherwise vulnerable viral epitopes. Interestingly, this O-glycan shield could be exploited for neutralization by lectins and carbohydrate-specific antibody. The conservation of O-glycosylation sites in all gp350 homologs suggests that this is a general evasion mechanism that may also provide a therapeutic target., Author Summary Herpesvirus transmission between immune hosts implies some kind of antibody evasion. However, the underlying molecular mechanisms remain largely unknown. All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus (EBV) gp350. Gp350 binds EBV to B cells and provides a neutralization target. However, despite its immunogenicity, EBV carriers remain infectious. Here we show that the gp350 homolog of the related Bovine Herpesvirus 4 (BoHV-4), gp180, and its O-glycans, shield some otherwise vulnerable viral epitopes. Extensive O-glycosylation is common to all gammaherpesvirus gp350 homologs, suggesting that this evasion mechanism is also widespread.

International audience; Tail-head linkage is a discourse pattern which consists in repeating, at the beginning of a new sentence, the main verb of the preceding sentence for discourse cohesion. This pattern, which is rarely discussed in general typological work, is widespread in certain areas of the globe, in particular Papua New Guinea. In this paper, I report a case of tail-head linkage in Cavineña, an Amazonian language spoken in the northern lowlands of Bolivia, in which it is manifested by way of three subordinate clause types: two temporal adverbial clauses and a relative clause used adverbially. I also show how the switch-reference system that is associated with certain of these clauses participates in the tail-head linkage system for participant coherence between sentences.

International audience; This paper is a brief introduction to this special issue of the International Journal of American Linguistics on argument-encoding systems of the little known languages of Bolivian Amazonia, a region extremely rich linguistically. After providing some information on the sociolinguistic settings and the history of linguistic research in this area, the paper focuses on the domain of argument-encoding systems in those languages. It shows how very diverse types of systems are found in languages spoken in very close proximity, including hierarchical/inverse cross-referencing systems, ergative systems and split-intransitive systems. The paper also points to a number of typologically and theoretically interesting phenomena found in these languages such as fluid transitivity, double object ditransitive constructions, and rare valency-changing derivations such as multiple applicatives and sociative causatives. Finally, the paper presents the contents of this special issue.

International audience; This paper discusses, for the first time, the peculiar system of person marking in Reyesano, an Amazonian language from northern Bolivia. Person marking in Reyesano is quite unusual. First, it is discontinuous, involving a prefix slot for the indexation of first and second persons and a suffix slot for the indexation of third persons. Second, the use of the person markers in the slots is conditioned by the complex interaction of distinct factors, involving the grammatical function of the participants (S, A, and O), their ranking on a person hierarchy (2 > 1 > 3), and their number (singular vs. plural).

International audience; The languages of South America and Australia are known for their morphologically and semantically elaborate systems of Associated Motion (AM). In contrast, the five Tungusic languages discussed here, which belong to the Northern and the Southern branch of the family, have only a single suffix pertaining to this category. This morpheme expresses a motion event that precedes the verb event. It is deictically neutral, i.e. can refer to both translocative and cislocative motion, although translocative readings predominate. The cross-linguistically most striking feature of AM in the Tungusic languages is the fact that not only base verb arguments can be expressed, but so can arguments typical of motion verbs, called 'spatial arguments' in the paper. We explore the argument structure of verbs marked with the AM-suffix in detail and find that both formal considerations (a preference for only one overt argument) and pragmatic considerations (the choice to foreground the spatial argument over the verb argument) play a role in which argument(s) get expressed.

This study is a typologically-informed description of a few major aspects of the grammar of a variety of Tikuna, a language isolate spoken in western Amazonia along the banks of the Amazon river. The Tikuna variety described in this work is that of San Martín de Amacayacu, a community located near the southeastern tip of Colombia. Its speakers typically refer to it as tăgà, lit. ‘our (incl.) language’ or ‘people’s language’, even when talking to foreigners. The grammatical topics covered primarily include the phonological system of the language as well as the morphosyntax and semantics of its predicative phrase. Additional grammatical domains treated in less detail include aspects of the nominal phrase and the expression of negation. All the analyses I put forward in this description are based on first-hand linguistic data that I have collected between 2015 and 2018 in San Martín de Amacayacu with the help of native speakers of the language., Cette étude consiste en une description de certains aspects de la grammaire d’un parler tikuna abordés depuis une perspective fonctionnelle et typologique. Le tikuna est une langue isolée parlée dans l’ouest de l’Amazonie sur les bords du fleuve Amazone. Le parler tikuna décrit dans cette étude correspond à celui de la communauté de San Martín de Amacayacu, située dans l’extrême sud-est de la Colombie. Les locuteurs de ce parler désignent généralement leur langue du nom de tăgà, littéralement ‘notre langue (nous inclusif)’ ou bien ‘langue des gens’, y compris dans leurs interactions avec des personnes non tikuna. Les deux principaux domaines de la grammaire de la langue traités dans ce travail sont d’une part son système phonologique, et d’autre part la morphosyntaxe et la sémantique de son syntagme prédicatif. Sont également abordés, avec moins de détail, certains aspects de la morphosyntaxe du syntagme nominal, ainsi que l’expression de la négation dans la langue. Les analyses avancées dans cette étude reposent presque exclusivement sur des données linguistiques de première main que j’ai rassemblées entre 2015 et 2018 à San Martín de Amacayacu avec l’aide de locuteurs natifs de la langue.

This dissertation is a comprehensive grammatical description of Namtrik, also known as Guambiano, an under described language of the Southwestern Colombian Andes spoken by about 23.242 people (Moseley, 2019). This grammar focus in a highly endangered dialect of Namtrik, spoken in the community of Totoró by 76 native speakers (1% of a total population of 7023 people) who are all over 50 years (Gonzales 2013:11). This dissertation is co-supervised by Antoine Guillaume (DDL, CNRS & Université lyon 2) and Tulio Rojas Curieux (Université du Cauca & GELPS). This dissertation includes a phonological, morpho-phonological, morphological and syntactic description of this language and is based on a Namtrik audio-video corpus collected in collaboration with trained members of the community. The HRELP-SOAS program funded this doctoral research project and also a documentation project of the language., Esta tesis doctoral dirigida por Antoine Guillaume (DDL, CNRS & Université lyon 2) y Tulio Rojas Curieux (Universidad del Cauca), presenta una descripción de la gramática de la lengua namtrik, también conocida como namui wam o guambiano, perteneciente a la familia barbacoa (Curnow y Liddicoat 1998). Esta lengua es hablada en el suroccidente colombiano por alrededor de 23.242 personas (Moseley, 2019), sobre la cordillera de los Andes, en el departamento del Cauca, en los resguardos de Guambia, Ambaló, Totoró, Quisgó y Jambaló. Esta gramática describe una variante seriamente amenazada delnamtrik, hablada en el resguardo de Totoró por alrededor de 76 hablantes, que corresponden al 1% de la población total de la comunidad (7023 habitantes) (Gonzales 2013)., Cette thèse porte sur la grammaire de la langue namtrik, connue aussi comme namui wam ou guambiano, appartenant à la famille linguistique Barbacoa (Curnow & Liddicoat, 1998). Cette langue est parlée dans le sud-ouest de la Colombie sur la cordillère des Andes par environ 23.242 (Moseley, 2019) locuteurs dans des communautés du département du Cauca. Cette thèse est une description d’une variété très menacée du namtrik parlé dans la communauté de Totoró par 1% de la population de la communauté (environ 76 personnes). Cette dissertation, menée sous la direction d’Antoine Guillaume (DDL, CNRS & Université lyon 2) et le co-encadrement de Tulio Rojas Curieux (Université du Cauca & GELPS), constitue la première grammaire descriptive de la langue namtrik dans un cadre typologique moderne.

National audience; Le muscle squelettique est un tissu plastique dont les protéines sont en constant renouvellement. La taille du compartiment protéique musculaire dépend de l’intensité respective des vitesses de synthèse et de dégradation des protéines. De nombreuses situations physiopathologiques (maladies neuro-dégénératives, cancers, vieillissement…) sont caractérisées par une atrophie musculaire survenant lorsque la protéolyse devient supérieure à la protéosynthèse. Parmi les différents systèmes impliqués dans la protéolyse musculaire, l’attention sera focalisée sur la voie ubiquitine-protéasome dépendante (UPS) et la voie lysosomale (autophagie). Cependant, la coopération d’autres systèmes semble nécessaire pour la dégradation des protéines contractiles majeures.