Search

Palladium-catalyzed aminocarbonylations of various (hetero)aryl halides with allylamine using Mo(CO)(6) as a solid, in situ CO source, were explored. Microwave-enhanced conditions proved to be highly useful in promoting the conversions in a mere 10-20 min with various (hetero)aryl iodides, bromides and chlorides. The scale-up of a microwave-enhanced aminocarbonylation to 25 mmol scale was performed successfully. (C) 2008 Elsevier Ltd. All rights reserved.

A selective over-view of the recent developments of microwave-assisted, transition-metal-catalysed C-C and C-N bond-forming reactions is presented. Microwave-assisted chemistry is a comparatively novel technique in the present-day synthetic world and has recently grown in an exponential manner, stretching from academia to a widely practiced technique in industry. Transition-metal-catalysed C-C and C-N bond-forming reactions represent one of the most interesting and well-investigated type of microwave-assisted reactions, evident from the plethora of available literature and patents in this area. Given the large number of articles published on the subject, we have made a very concise selection from the recent literature, covering manuscripts dealing with the subject from the period of the end 2004 until the first part of 2007.

Two novel and efficient strategies for the synthesis of hitherto unknown N-shifted and ring-expanded buflavine analogues are presented. Construction of the medium-sized ring system of the title molecules, a difficult task due to the high activation energy needed for the ring-closure with the additional rigidity imposed by the biaryl skeleton, was achieved by using Suzuki-Miyaura biaryl coupling and a ring-closing metathesis reaction as the key steps. The combination of a second-generation Grubbs catalyst and microwave irradiation proved to be highly useful in generating the otherwise difficult to obtain medium-sized ring system of the buflavine analogues.