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1. Proceedings of the 9th international symposium on veterinary rehabilitation and physical therapy

Author

Elodie Nemery, Annick Gabriel, Dominique Cassart, Calixte Bayrou, Joëlle Piret, Nadine Antoine, Monika Nilsson, Lars Steinwall, Inger Jacobson, Ângela Martins, Carla Carvalho, Inês Viegas, Denis J. Marcellin-Little, Ola L. A. Harrysson, Christopher S. Crimi, David Levine, María Calatayud, María Resano, Marion Mucha, Ivonne Virac, Cornelia Lang, Kathleen Wittek, Alexander Tichy, Barbara Bockstahler, J. Randy Walker, Āren Swogger, Tavis Gibson, Janice Ryan, Chris Gilligan, Katie Haulcomb, Leigh Anne Norris, Matt Powers, Tracy Pugh, Seth Purkey, Hanna Pulkkinen, Anu Lappalainen, Outi Laitinen-Vapaavuori, Heli Hyytiäinen, Ann Essner, Rita Sjöström, Lena Zetterberg, Karin Hellström, Pia Gustås, Hans Högberg, Anna Hielm-Björkman, Charlotte Orrfors, Gunnevi Sundelin, Luísa Gonçalves, João Niza-Ribeiro, Darryl L. Millis, Augusto José de Matos, Marinette Teeling, Kate Ross, Victoria Geddes, Ann Carstens, Tineka Kriel, Karien du Toit, Jeanette Pauw, Gillian Martindale, Kristine Mylo, Sybrand S. van den Berg, Morito Ogasawara, Hiromi Noguchi, Takeo Minami, Krzysztof Zdeb, Urszula Baumgart, Ana M. Ribeiro, Ricardo Palas, Martinho Capelão, Mila Speciani, Alessandra De Luca, Elisa Anzolin, Nina Pirinen, Matti Pastell, Anna Mykkänen, Jonna Jokisalo, Kati Niinistö, Laura Hänninen, Catherine McGowan, Alexandria Holt, Marta Subirats, Maria Perez, Tatiana Hernández, Luna Gutierrez-Cepeda, Rafael Cediel, Javier López-San Román, Anna F. Boström, Lotta Savolainen, Anu K. Lappalainen, Sarah Stadig, Linda Lundström, Anna Bergh, Charles Ley, Lena Olsén, Carina Ingvast-Larsson, Renata Diniz, Cristina Nicolau, Antonio Gamundi, Mourad Akaarir, Elizabeth Roberts, Leander McLennan, Helen C. Cartildge, Lucy K. M. Evans, Stephen Baugh, Pernilla Stenfeldt, Cajsa Ericson, Linnéa Söderberg, Lennart Sjöström, Robert Colborne, Anna Byström, Marti Drum, Marie de Swarte, Federica Morandi, José Guevara, Dawn Hickey, Ellen Camp, and Rachel Dickson

Subjects
medicine.medical_specialty, Index (economics), General Veterinary, 040301 veterinary sciences, business.industry, 0402 animal and dairy science, Measure (physics), Chronic pain, social sciences, 04 agricultural and veterinary sciences, General Medicine, Osteoarthritis, medicine.disease, Meeting Abstracts, 040201 dairy & animal science, humanities, 3. Good health, 0403 veterinary science, Physical therapy, population characteristics, Medicine, business, health care economics and organizations, geographic locations
Abstract

Validation of a Swedish version of the Helsinki Chronic Pain Index for the measure of chronic pain behaviors in canine osteoarthritis

Published
2016
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2. Sialylation regulates galectin-3/ligand interplay during mammary tumour progression--a case of targeted uncloaking

Author

Joana-Tavares de Oliveira, Fátima Gärtner, Joana Gomes, Emerson Soares Bernardes, Gerard R. Rutteman, Venceslau Hespanhol, Celso A. Reis, Roger Chammas, Rita Pinto, Augusto-José de Matos, Aki Manninen, and Ana L. Santos

Subjects
Embryology, Cell Survival, Galectin 3, Transplantation, Heterologous, Down-Regulation, Mice, Nude, Mammary Neoplasms, Animal, Ligands, Models, Biological, chemistry.chemical_compound, Mice, Dogs, Antigen, Cell Line, Tumor, otorhinolaryngologic diseases, Cell Adhesion, Animals, Anoikis, Antigens, Tumor-Associated, Carbohydrate, Neoplasm Invasiveness, Epidermal growth factor receptor, Dog Diseases, MUC1, Feedback, Physiological, Binding Sites, biology, Mucin-1, Immunohistochemistry, Sialic acid, Up-Regulation, ErbB Receptors, stomatognathic diseases, chemistry, Cell culture, Galectin-3, Cancer cell, Immunology, Cancer research, biology.protein, Disease Progression, Sialic Acids, Female, Developmental Biology
Abstract

Galectin-3 is involved both in facilitating detachment of cells from primary tumour sites and favouring cancer cell adhesion and survival to anoikis in the blood stream. The mechanisms behind these apparently contradictory roles of the lectin have not yet been resolved. In order to investigate possible interplays between galectin-3 and its ligands underlying their role in the metastatic process, we examined mucin-1 (MUC1) and epidermal growth factor receptor (EGFR), well-known galectin-3 ligands, as well as galectin-3-binding site expression in a series of spontaneous canine malignant mammary tumours (CMMT) and a metastatic CMMT cell line. Despite the fact that CMMT cells expressed MUC1 and EGFR homogeneously over their plasma membrane, intravascular tumour cells, positive for galectin-3, expressed MUC1 and EGFR in a more focal membrane localization. Moreover, MUC1 overexpression in primary CMMT was present in parallel with down-regulation of galectin-3. Furthermore, in the CMT-U27 cell line, galectin-3 knock-down led to increased MUC1 expression, while MUC1 knock-down led to down-regulation of the lectin. Finally, removal of sialic acid from both CMMT and CMT-U27 xenograft samples exposed galectin-3-ligands throughout the tumour tissue, whereas these ligands were only present in galectin-3-positive invading cells in untreated samples. Interestingly indeed, we show that in vessel-invading cells, there is interaction between galectin-3 and the T antigen in vivo. We therefore hypothesized that loss of galectin-3 and sialylation-related masking of its ligands, in conjunction with their overexpression in specific tumour cell subpopulations, are crucial in regulating adhesive/de-adhesive events in the progression and invasive capacity of metastatic cells.

Published
2011

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