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1. Ultrasound Biomicroscopy Measurements of the Normal Thickness for the Ciliary Body and the Iris in a Middle East Population

Author

Yousef YA, Mohammad M, AlNawaiseh I, AlJabari R, Toro MD, Gharaibeh A, Rejdak R, Nowomiejska K, Zweifel S, Avitabile T, Rejdak M, and Nazzal R

Subjects
ultrasound biomicroscopy, iris, ciliary body, Ophthalmology, RE1-994
Abstract

Yacoub A Yousef,1 Mona Mohammad,1 Ibrahim AlNawaiseh,1 Reem AlJabari,1 Mario Damiano Toro,2,3 Almutez Gharaibeh,4 Robert Rejdak,5 Katarzyna Nowomiejska,5 Sandrine Zweifel,3 Teresio Avitabile,6 Magdalena Rejdak,6 Rashed Nazzal2 1Department of Surgery (Ophthalmology), King Hussein Cancer Centre, Amman, Jordan; 2Faculty of Medical Sciences, Collegium Medicum, Cardinal Stefan Wyszyński University, Warsaw, Poland; 3Department of Ophthalmology, University of Zürich, Zürich, Switzerland; 4School of Medicine, The University of Jordan, Amman, Jordan; 5Department of General Ophthalmology, Medical University of Lublin, Lublin, Poland; 6Department of Ophthalmology, University of Catania, Catania, ItalyCorrespondence: Yacoub A YousefDepartment of Surgery (Ophthalmology), King Hussein Cancer Centre, Queen Rania St, Amman, 11941, JordanTel +96265355000Email yyousef@khcc.joMario Damiano ToroDepartment of Ophthalmology, University Hospital of Zürich, Raemistrasse 100, Zürich, 8091, SwitzerlandTel +39 3495158220Email toro.mario@email.itPurpose: Ciliary body (CB) and iris thicknesses may change with certain eye diseases as well as between different populations. Here, we report Ultrasound Biomicroscopy Measurements (UBM) of the normal thickness for the CB and the iris from a homogenous population in the Middle East.Patients and Methods: Sonomed 35-MHz (SONOMED, INC. New York, USA) images were obtained at 4 radial meridians, and the thickness was measured at 3 locations along the radial length of the iris and at the thickest part of the CB. Parameters included mean thickness, median thickness, range, and standard deviation.Results: Of 46 adult patients, 83 normal eyes were included in this analysis. The overall mean, median iris thicknesses at the iris root, midway along the radial length of the iris, and at the juxtapupillary margin in mm were 0.42, 0.41 ± 0.08, 0.52, 0.51± 0.08, and 0.72, 0.71± 0.1, respectively. The overall mean, median thicknesses of the CB and CB + ciliary processes in mm were 0.72, 0.71 ± 0.1, and 1.42, 1.37 ± 0.2 respectively. Gender, age, side, and height had no impact on iris and/or CB thickness (p> 0.05). However, the iris thickness was significantly thicker in the superior quadrant than inferiorly, and in the nasal quadrant than the temporal quadrant (p=0.04), and the CB thickness and the CB + ciliary processes thickness were significantly thicker in the superior quadrant than inferiorly (P = 0.04 and 0.02 consecutively).Conclusion: We measured in this study the normal thickness of the CB and the iris in normal eyes from homogenous population in the Middle East using ultrasound biomicroscopy. Our findings are essential for the ophthalmic community worldwide and in the Middle East region and can be used as a normative thickness data for the iris and CB in healthy eyes.Keywords: ultrasound biomicroscopy, iris, ciliary body

Published
2022

2. Widening use of dexamethasone implant for the treatment of macular edema

Author

Bonfiglio V, Reibaldi M, Fallico M, Russo A, Pizzo A, Fichera S, Rapisarda C, Macchi I, Avitabile T, and Longo A

Subjects
Macular edema, dexamethasone, intravitreal, implant, corticosteroids, Therapeutics. Pharmacology, RM1-950
Abstract

Vincenza Bonfiglio, Michele Reibaldi, Matteo Fallico, Andrea Russo, Alessandra Pizzo, Stefano Fichera, Carlo Rapisarda, Iacopo Macchi, Teresio Avitabile, Antonio Longo Department of Ophthalmology, University of Catania, Catania, Italy Abstract: Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of efficacy between injections with a good safety profile. Various other ocular pathologies with inflammatory etiopathogeneses associated with macular edema have been treated by DEX implant, including neovascular age-related macular degeneration, Irvine–Gass syndrome, vasoproliferative retinal tumors, retinal telangiectasia, Coats’ disease, radiation maculopathy, retinitis pigmentosa, and macular edema secondary to scleral buckling and pars plana vitrectomy. We undertook a review to provide a comprehensive collection of all of the diseases that benefit from the use of the sustained-release DEX implant, alone or in combination with concomitant therapies. A MEDLINE search revealed lack of randomized controlled trials related to these indications. Therefore we included and analyzed all available studies (retrospective and prospective, comparative and non-comparative, randomized and nonrandomized, single center and multicenter, and case report). There are reports in the literature of the use of DEX implant across a range of macular edema-related pathologies, with their clinical experience supporting the use of DEX implant on a case-by-case basis with the aim of improving patient outcomes in many macular pathologies. As many of the reported macular pathologies are difficult to treat, a new treatment option that has a beneficial influence on the clinical course of the disease may be useful in clinical practice. Keywords: macular edema, dexamethasone, intravitreal, implant, corticosteroids

Published
2017

3. Folate status in type 2 diabetic patients with and without retinopathy

Author

Malaguarnera G, Gagliano C, Salomone S, Giordano M, Bucolo C, Pappalardo A, Drago F, Caraci F, Avitabile T, and Motta M

Subjects
Ophthalmology, RE1-994
Abstract

Giulia Malaguarnera,1 Caterina Gagliano,2,3 Salvatore Salomone,1 Maria Giordano,4 Claudio Bucolo,1 Antonino Pappalardo,5 Filippo Drago,1 Filippo Caraci,6,7 Teresio Avitabile,2 Massimo Motta51Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; 2Department of Ophthalmology, University of Catania, Catania, Italy; 3Neurovisual Science Technology (NEST), Catania, Catania, Italy; 4Gerontology and Bone Metabolic Disease Section, Department of Medical Sciences, University of Turin, Turin; 5Department of Medical and Paediatric Sciences, University of Catania, Italy; 6Department of Drug Sciences, University of Catania, Catania, Italy; 7IRCCS Association Oasi Maria S.S.-Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, ItalyBackground: Folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia. This study has been undertaken to investigate the role of folate status during the progression of the diabetic retinopathy.Methods: We measured the plasma levels of homocysteine, folic acid, and red cell folate in 70 diabetic type 2 patients with nonproliferative diabetic retinopathy (NPDR), 65 with proliferative diabetic retinopathy (PDR), 96 without diabetic retinopathy, and 80 healthy subjects used as a control group.Results: We found higher plasma levels of homocysteine in the NPDR group compared to the control group (P

Published
2015

5. Validation of Esaso Classification of Diabetic Maculopathy

Author

Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., Scupola A., Panozzo, G., Franzolin, E., Giannarelli, Diana, Dalla Mura, G., Longo, Anita Rosa, Cicinelli, M. V., Angelini, E., Airaghi, P., Avitabile, T., Bandello, F., Beccastrini, A., Benedetti, G., Bertuzzi, Paolo Francesco, Bonfiglio, V. M. E., Boscia, F., Carnevali, A., Carosielli, M., Cereda, M. G., Contardi, C., Coppola, M., Costagliola, C., Cristofolini, R., Cucciniello, P., D'Aloisio, R., De Bernardo, M., De Filippis, Alessandro, Dell'Omo, Roberto, Di Paola, I., Dell'Acqua, Massimiliano, Franco, Alessio, Grassi, M. O., Gregori, G., Gusson, E., Lattanzio, R., Lanzetta, P., Longo, A., Marchini, G., Marolo, P., Mastropasqua, R., Bertoldo, G. M., Monteleone, Giorgio, Ortisi, E., Parisi, Giuseppe, Parrulli, S., Pucci, P., Pastore, M. R., Reibaldi, M., Rizzo, Stanislao, Romano, Federica, Rosa, N., Sarao, V., Scarpa, G., Scorcia, V., Scupola, Andrea, Staurenghi, G., Sunseri Trapani, V., Tognetto, D., Trabucchi, G., Vaccaro, S., Vadala, M., Veritti, D., Vinciguerra, A. L., Zanzottera, E. C., Giannarelli D., Longo R., Bertuzzi F., De Filippis A., Dell'Omo R., Dell'Acqua M., Franco A., Monteleone G., Parisi G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., and Scupola A.

Abstract

Purpose: To test reliability and reproducibility of ESASO morphologic OCT-based classification of diabetic maculopathy (DM). Methods: This is a multi-center cross-sectional study including a coordination center (CC) and 18 participating centers (PCs). After instruction on the correct use of ESASO Classification, the validation process was carried out in two consecutive stages. In the first retrospective phase, we evaluated the concordance between PCs and CC in the staging of OCT images collected during PCs’ daily activity (608 images). In a second prospective phase, we analyzed the inter-observer agreement of staging assigned by each PCs to OCT images selected by the CC (22 images). Results: The overall concordance achieved in the retrospective phase was 89.8% (Kappa = 0.83 (95% CI: 0.78–0.87); p<0.0001). In 99.5% of cases, concordance did not differ by more than one stage. In the prospective phase, PCs reached an inter-operator agreement of 93.0% (Krippendorff's Alpha = 0.953, 95% CI: 0.929–0.977, p<0.0001). Any discrepancy among the 22 images was within one stage. Conclusion: The results achieved in this study confirm that ESASO OCT-based Classification can be considered as an easy and reproducible method to stage DM during clinical practice. A diffused use of a common and validated method to describe the progression of retinal damage in DM may offer several clinical and scientific advantages.

Published
2023

6. Effect of COVID-19-related lockdown on ophthalmic practice in Italy: A report from 39 institutional centers

Author

Dell'Omo, Roberto, Filippelli, M., Virgili, Gianni, Bandello, F., Querques, G., Lanzetta, P., Avitabile, T., Viola, F., Reibaldi, M., Semeraro, F., Quaranta, L., Rizzo, Stanislao, Midena, E., Campagna, G., Costagliola, C., Marolo, P., Traverso, C. E., Iester, M., Cutolo, C. A., Azzolini, C., Donati, S., Premi, E., Nucci, P., Vujosevic, S., Staurenghi, G., Bottoni, F., Romano, Federica, Grosso, D., Borrelli, E., Sacconi, R., Milella, P., Ganci, S., Romano, M. R., Ricciardelli, G., Allegrini, D., Casaluci, M., Romano, D., Marchini, G., Chemello, F., Amantea, Carlotta, Frisina, R., Pilotto, E., Parrozzani, R., Veritti, D., Sarao, V., Daniele, T., Busin, M., Parmeggiani, F., De Nadai, K., Furiosi, L., Mastropasqua, R., Battaglia, B., Gironi, Marco, Gandolfi, S., Luciani, E., Mora, P., Schiavi, C., Bertaccini, Paolo Antonio, Finzi, A., Roda, M., Cagini, C., Lupidi, M., Giansanti, F., Bacherini, Daniela, Tosi, G., De Benedetto, E., Nardi, M., Figus, M., Posarelli, C., Mariotti, Cesare, Pirani, V., Nicolai, Massimo, Bonini, S., Coassin, M., Di Zazzo, A., Savastano, Maria Cristina, Savastano, Alfonso, Gambini, Gloria, Vico, U. D., Spadea, L., Iannaccone, A., Nucci, C., Ricci, F., Aiello, F., Afflitto, G. G., Mastropasqua, L., D'Onofio, G., Evangelista, F., Brescia, L., Napolitano, P., Polisena, P., Gianfrancesco, N., Trivisonno, D., Petti, F., Simonelli, F., Rossi, S., Tartaglione, A., Rosa, N., Bernardo, M. D., Iaculli, C., Valeria Bux, A., Maggiore, Giuseppe, Boscia, F., Sborgia, G., Grassi, M. O., Scorcia, V., Giannaccare, G., Parisi, Giuseppe, Cillino, S., Alaimo, F., Aragona, P., Meduri, A., Pinna, A., Sollazzo, A., Peiretti, E., Siotto, E., dell'Omo R., Virgili G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., Amantea C., Gironi M., Bertaccini P., Bacherini D., Mariotti C., Nicolai M., Savastano M. (ORCID:0000-0003-1397-4333), Savastano A., Gambini G., Maggiore G., Parisi G., Dell'Omo, Roberto, Filippelli, M., Virgili, Gianni, Bandello, F., Querques, G., Lanzetta, P., Avitabile, T., Viola, F., Reibaldi, M., Semeraro, F., Quaranta, L., Rizzo, Stanislao, Midena, E., Campagna, G., Costagliola, C., Marolo, P., Traverso, C. E., Iester, M., Cutolo, C. A., Azzolini, C., Donati, S., Premi, E., Nucci, P., Vujosevic, S., Staurenghi, G., Bottoni, F., Romano, Federica, Grosso, D., Borrelli, E., Sacconi, R., Milella, P., Ganci, S., Romano, M. R., Ricciardelli, G., Allegrini, D., Casaluci, M., Romano, D., Marchini, G., Chemello, F., Amantea, Carlotta, Frisina, R., Pilotto, E., Parrozzani, R., Veritti, D., Sarao, V., Daniele, T., Busin, M., Parmeggiani, F., De Nadai, K., Furiosi, L., Mastropasqua, R., Battaglia, B., Gironi, Marco, Gandolfi, S., Luciani, E., Mora, P., Schiavi, C., Bertaccini, Paolo Antonio, Finzi, A., Roda, M., Cagini, C., Lupidi, M., Giansanti, F., Bacherini, Daniela, Tosi, G., De Benedetto, E., Nardi, M., Figus, M., Posarelli, C., Mariotti, Cesare, Pirani, V., Nicolai, Massimo, Bonini, S., Coassin, M., Di Zazzo, A., Savastano, Maria Cristina, Savastano, Alfonso, Gambini, Gloria, Vico, U. D., Spadea, L., Iannaccone, A., Nucci, C., Ricci, F., Aiello, F., Afflitto, G. G., Mastropasqua, L., D'Onofio, G., Evangelista, F., Brescia, L., Napolitano, P., Polisena, P., Gianfrancesco, N., Trivisonno, D., Petti, F., Simonelli, F., Rossi, S., Tartaglione, A., Rosa, N., Bernardo, M. D., Iaculli, C., Valeria Bux, A., Maggiore, Giuseppe, Boscia, F., Sborgia, G., Grassi, M. O., Scorcia, V., Giannaccare, G., Parisi, Giuseppe, Cillino, S., Alaimo, F., Aragona, P., Meduri, A., Pinna, A., Sollazzo, A., Peiretti, E., Siotto, E., dell'Omo R., Virgili G., Rizzo S. (ORCID:0000-0001-6302-063X), Romano F., Amantea C., Gironi M., Bertaccini P., Bacherini D., Mariotti C., Nicolai M., Savastano M. (ORCID:0000-0003-1397-4333), Savastano A., Gambini G., Maggiore G., and Parisi G.

Abstract

Background/objectives: To compare the number of eye surgical procedures performed in Italy in the 2 months following the beginning of lockdown (study period) because of COVID-19 epidemic with those performed in the two earlier months of the same year (intra-year control) and in the period of 2019 corresponding to the lockdown (inter-year control). Methods: Retrospective analysis of surgical procedures carried out at 39 Academic hospitals. A distinction was made between elective and urgent procedures. Intravitreal injections were also considered. Percentages for all surgical procedures and incidence rate ratios (IRR) for rhegmatogenous retinal detachment (RRD) events were calculated. A p value <0.05 was considered significant. Results: A total of 20,886 versus 55,259 and 56,640 patients underwent surgery during the lockdown versus intra-and inter-year control periods, respectively. During the lockdown, only 70% of patients for whom an operation/intravitreal injection was recommended, finally underwent surgery; the remaining patients did not attend because afraid of getting infected at the hospital (23%), taking public transportation (6.5%), or unavailable swabs (0.5%). Elective surgeries were reduced by 96.2% and 96.4%, urgent surgeries by 49.7% and 50.2%, and intravitreal injections by 48.5% and 48.6% in the lockdown period in comparison to intra-year and inter-year control periods, respectively. IRRs for RRDs during lockdown dropped significantly in comparison with intra- and inter-year control periods (CI: 0.65–0.80 and 0.61–0.75, respectively, p < 0.001 for both). Conclusion: This study provides a quantitative analysis of the reduction of eye surgical procedures performed in Italy because of the COVID-19 epidemic.

Published
2022

7. Correction: One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy (Eye, (2020), 10.1038/s41433-020-0869-1)

Author

Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, S., Biagini, I., Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, C., Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., Ciprandi, G., Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, S., Biagini, I., Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, C., Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., and Ciprandi, G.

Subjects
not available, Drug Therapy
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

8. Correction: Circulating insulin-like growth factor-1: A new clue in the pathogenesis of age-related macular degeneration [Aging (Albany NY), 10 (2018) (4241-4247)] DOI:10.18632/aging.101727

Author

Castellino, N., Longo, A., Avitabile, T., Russo, A., Fallico, M., Bonfiglio, V., Toro, M. D., Rejdak, R., Murabito, P., Furino, C., Reibaldi, M., Castellino N., Longo A., Avitabile T., Russo A., Fallico M., Bonfiglio V., Toro M.D., Rejdak R., Murabito P., Furino C., Reibaldi M., Castellino, N., Longo, A., Avitabile, T., Russo, A., Fallico, M., Bonfiglio, V., Toro, M. D., Rejdak, R., Murabito, P., Furino, C., and Reibaldi, M.

Subjects
correction
Abstract

circulating insulin like

Published
2018

11. Correction: One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy (Eye, (2020), 34, 11, (2112-2122), 10.1038/s41433-020-0869-1)

Author

Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, Stanislao, Biagini, Ilaria, Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, Cesare, Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., Ciprandi, G., Rizzo S. (ORCID:0000-0001-6302-063X), Biagini I., Mariotti C., Bandello, F., Coassin, M., Di Zazzo, A., Rizzo, Stanislao, Biagini, Ilaria, Pozdeyeva, N., Sinitsyn, M., Verzin, A., De Rosa, P., Calabro, F., Avitabile, T., Bonfiglio, V., Fasce, F., Barraquer, R., Mateu, J. L., Kohnen, T., Carnovali, M., Malyugin, B., Aragona, P., Arvedi, P., Cagini, C., Caretti, L., Cavallini, G. M., Cillino, S., Figini, I., Franco, L. M., La Mantia, A., Laborante, A., Lanzetta, P., Marcigaglia, M., Mariotti, Cesare, Martini, E., Mastropasqua, L., Morselli, S., Passani, F., Pece, A., Pertile, G., Pioppo, A., Pirondini, C., Prantera, M., Rapisarda, A., Romano, M. R., Scarpa, G., Schiano-Lomoriello, D., Scorcia, V., Scuderi, G., Semeraro, F., Spedale, F., Staurenghi, G., Tognetto, D., Tosi, M., Trabucchi, G., Trivella, F., Villani, E., Vento, A., Vinciguerra, P., Alio, J. L., Alfonso Sanchez, J. F., Montiel, F. A., Lorenz, K., Panova, I., Eremina, A., Ciprandi, G., Rizzo S. (ORCID:0000-0001-6302-063X), Biagini I., and Mariotti C.

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

12. Prevalence of diabetes and diabetic macular edema in patients undergoing senile cataract surgery in Italy: The DIabetes and CATaract study

Author

Panozzo, G., Staurenghi, G., Dalla Mura, G., Giannarelli, Diana, Alessio, G., Alongi, S., Appolloni, R., Baldascino, Antonio, Boscia, F., Caporossi, Aldo, Cereda, M., D'Ugo, E., Fallico, M., Avitabile, T., Galan, A., La Spina, C., Lo Giudice, G., Mastropasqua, L., Palmisano, C., Panico, C., Parravano, M. C., Penna, R., Pintore, P., Vaiano, A., Reibaldi, M., Rizzo, Stanislao, Rossi, Tommaso, Varano, M., Virgili, Gianni, Giannarelli D., Baldascino A., Caporossi A. (ORCID:0000-0002-8680-3773), Rizzo S. (ORCID:0000-0001-6302-063X), Rossi T., Virgili G., Panozzo, G., Staurenghi, G., Dalla Mura, G., Giannarelli, Diana, Alessio, G., Alongi, S., Appolloni, R., Baldascino, Antonio, Boscia, F., Caporossi, Aldo, Cereda, M., D'Ugo, E., Fallico, M., Avitabile, T., Galan, A., La Spina, C., Lo Giudice, G., Mastropasqua, L., Palmisano, C., Panico, C., Parravano, M. C., Penna, R., Pintore, P., Vaiano, A., Reibaldi, M., Rizzo, Stanislao, Rossi, Tommaso, Varano, M., Virgili, Gianni, Giannarelli D., Baldascino A., Caporossi A. (ORCID:0000-0002-8680-3773), Rizzo S. (ORCID:0000-0001-6302-063X), Rossi T., and Virgili G.

Abstract

Background: The purpose of this study is to determine the prevalence of diabetes and diabetic macular edema in patients undergoing senile cataract surgery in Italy. Methods: It is a prospective, multicenter, cross-sectional study. Thirteen ophthalmic units equally distributed across the Italian territory have been involved in the study. For a period of 3 months, all subjects undergoing phacoemulsification received an Optical Coherence Tompgraphy (OCT) scan and were screened for the anamnestic presence of diabetes. In addition, five selected units collected blood samples from all their patients to measure glycated hemoglobin (HbA1c) levels and detect the presence of occult diabetes (HbA1c > 6.5%). In diabetic patients, levels of retinopathy were measured and diabetic macular edema was considered significant (clinically significant macular edema) when foveal thickness was above 30% of normal levels. Results: A total number of 3657 subjects have been screened. Among them, 20.4% were diabetics. Prevalence of diabetes was significantly higher in males (24.7%) than in females (17%). Levels of HbA1c were tested in a representative sample of 1216 consecutive subjects, and occult diabetes was diagnosed in 4.8% of cases. No significant differences were observed between age groups or different geographic areas. Among diabetic patients, diabetic macular edema of any kind was present in 27.5% (clinically significant macular edema (6.6%)). No significant differences were seen in the prevalence of diabetic macular edema between males and females or between age groups. Among the 745 diabetic patients, no signs of retinopathy were seen in 537 subjects (76.3%), while 101 patients (14.3%) had nonproliferative retinopathy, 13 (1.7%) had nontreated proliferative diabetic retinopathy, and 53 (7.5%) had laser-treated retinopathy. In the entire sample of 3657 subjects, a normal macula was present in 90.9% of cases, diabetic macular edema of any kind in 5.4%, and other maculopathies in 3

Published
2020

15. The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study

Author

Reibaldi, M, Avitabile, T, Bandello, F, Longo, A, Bonfiglio, V, Russo, A, Castellino, N, Rejdak, R, Nowomiejska, K, Toro, M, Furino, C, Cillino, S, Fiore, T, Cagini, C, Grassi, P, Musumeci, R, Cocuzza, C, Martinelli, M, Fallico, M, Cocuzza, CE, Reibaldi, M, Avitabile, T, Bandello, F, Longo, A, Bonfiglio, V, Russo, A, Castellino, N, Rejdak, R, Nowomiejska, K, Toro, M, Furino, C, Cillino, S, Fiore, T, Cagini, C, Grassi, P, Musumeci, R, Cocuzza, C, Martinelli, M, Fallico, M, and Cocuzza, CE

Abstract

The study purpose was to assess the efficacy of a preservative-free 0.6% povidone iodine eye drops as perioperative prophylactic treatment for reducing conjunctival bacterial load and the rate of needle contamination in patients undergoing intravitreal anti-vascular endothelial growth factor injection. Enrolled patients were randomized to either the study group (0.6% povidone iodine, three day-prophylactic treatment before the injection) or to the control group (placebo, three day-prophylactic treatment). Conjunctival swabs were obtained before and after the prophylactic treatment in both groups. Intravitreal injections were performed in a sterile fashion. The injection needle and a control needle were collected for microbiological culture. Data from 254 and 253 eyes in the study group and control group, respectively, were analyzed. Bacterial growth from conjunctival swab cultures was significantly lower after 0.6% povidone iodine prophylaxis compared to baseline and to placebo prophylaxis (p < 0.001), showing an 82% eradication rate in the study group. No injection needle showed bacterial contamination in the study group, whereas six needles were culture-positive in the control group (p = 0.015). No serious ocular and non-ocular adverse events were recorded. The 0.6% povidone iodine solution proved an effective treatment in reducing conjunctival bacterial load and risk of needle contamination.

Published
2019

16. miRNAs in the vitreous humor of patients affected by idiopathic epiretinal membrane and macular hole

Author

Russo A, Ragusa M, Barbagallo C, Longo A, Avitabile T, Uva MG, Bonfiglio V, Toro M, Caltabiano R, Mariotti C, Boscia F, Romano MR, Di Pietro C, Barbagallo D, Purrello M, Reibaldi M, Russo, Andrea, Ragusa, Marco, Barbagallo, Cristina, Longo, Antonio, Avitabile, Teresio, Uva, Maurizio G, Bonfiglio, Vincenza, Toro, Mario D, Caltabiano, Rosario, Mariotti, Cesare, Boscia, Francesco, Romano, Mario R, Di Pietro, Cinzia, Barbagallo, Davide, Purrello, Michele, Reibaldi, Michele, Russo, A, Ragusa, M, Barbagallo, C, Longo, A, Avitabile, T, Uva, Mg, Bonfiglio, V, Toro, M, Caltabiano, R, Mariotti, C, Boscia, F, Romano, Mr, Di Pietro, C, Barbagallo, D, Purrello, M, and Reibaldi, M

Subjects
Male, Multidisciplinary, lcsh:R, lcsh:Medicine, Correction, Down-Regulation, Epiretinal Membrane, Middle Aged, Retinal Perforations, Vitreous Body, MicroRNAs, Vitrectomy, Humans, lcsh:Q, Female, Prospective Studies, lcsh:Science, Transcriptome, miRNA, macular hole
Abstract

The aim of the present study was to assess the expression of miRNAs in the Vitreous Humor (VH) of patients with Macular Hole (MH) and Epiretinal Membrane (ERM) compared to a control group.In this prospective, comparative study, 2-ml of VH was extracted from the core of the vitreous chamber in consecutive patients who underwent standard vitrectomy for ERM and MH. RNA was extracted and TaqMan® Low Density Arrays (TLDAs) were used to profile the transcriptome of 754 miRNAs. Results were validated by single TaqMan® assays. Finally, we created a biological network of differentially expressed miRNA targets and their nearest neighbors.Overall 10 eyes with MH, 16 eyes with idiopathic ERM and 6 controls were enrolled in the study. Profiling data identified 5 miRNAs differentially expressed in patients affected by MH and ERM with respect to controls. Four were downregulated (miR-19b, miR-24, miR-155, miR-451) and 1 was downregulated (miR-29a); TaqMan® assays of the VH of patients affected by MH and ERM, with respect to controls, showed that the most differentially expressed were miR-19b (FC -9.13, p:0.00004), mir-24 (FC -7.52, p:0.004) and miR-142-3p (FC -5.32, p:0.011). Our network data showed that deregulation of differentially expressed miRNAs induces an alteration of several pathways associated with genes involved in both MH and ERM.The present study suggests that disregulation of miR-19b, miR-24 and miR-142-3p, might be related to the alterations that characterize patients affected by MH and ERM.

Published
2017

35. Malattie dell'apparato visivo

Author

Miglior, S, Avitabile, T, Bonini, S, Campos, E, Mastropasqua, L, MIGLIOR, STEFANO, Mastropasqua, L., Miglior, S, Avitabile, T, Bonini, S, Campos, E, Mastropasqua, L, MIGLIOR, STEFANO, and Mastropasqua, L.

Published
2014

43. Long-term efficacy of latanoprost in primary congenital glaucoma.

Author

Uva, M G, Avitabile, T, Reibaldi, M, Bucolo, C, Drago, F, Quaranta, L, Lionetti, E, and Longo, A

Subjects
*CONGENITAL glaucoma, *INTRAOCULAR pressure, *GLAUCOMA treatment, *HEALTH outcome assessment, *CHILD patients, *MULTIVARIATE analysis, GLAUCOMA surgery
Abstract

PurposeTo investigate the success (glaucoma control) of latanoprost therapy of primary congenital glaucoma (PCG) and factors affecting the long-term outcome.MethodsPatients with PCG treated with latanoprost were re-examined. At study visit and from clinical charts, we evaluated: intraocular pressure, length of glaucoma control with latanoprost, need of further medication or glaucoma surgery, systemic and topical side effects. Multivariate analysis was used to test factors related to the final outcome of the treatment.ResultsEighty-one eyes of 44 patients with PCG, and 42 eyes of 29 patients with previous glaucoma surgery, had received latanoprost therapy. In the first group, a success (glaucoma control by latanoprost therapy) was found in 24 eyes (29.6%), whereas 57 eyes (70.4%) had received surgery (45 eyes (55.6%) in the first year); among the eyes with previous surgery, a success was found in 12 eyes (28.6%), 13 eyes (31%) required an additional therapy, and 17 eyes (40.5%) had received further glaucoma surgery. No patient discontinued the treatment because of side effects. Factors related to the failure of the latanoprost treatment were: the high score of severity of glaucoma (P=0.014) and low age at PCG presentation (P=0.042).ConclusionsLong-term treatment with latanoprost is effective in about 30% of the eyes; factors related to failure were severe glaucomatous alterations, and young age at PCG presentation. [ABSTRACT FROM AUTHOR]

Published
2014
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45. Intravitreal dexamethasone implant versus anti-vascular endothelial growth factor therapy combined with cataract surgery in patients with diabetic macular oedema: a systematic review with meta-analysis

Author

Andrea Maugeri, Gilda Cennamo, Paola Marolo, Andrew J. Lotery, Martina Barchitta, Claudio Furino, Guglielmo Parisi, Michele Reibaldi, Antonella Agodi, Antonio Longo, Giuliana Favara, Vincenza Bonfiglio, Enrico Borrelli, Matteo Fallico, Teresio Avitabile, Andrea Russo, Fallico M., Lotery A., Maugeri A., Favara G., Barchitta M., Agodi A., Russo A., Longo A., Bonfiglio V., Avitabile T., Marolo P., Borrelli E., Parisi G., Cennamo G., Furino C., Reibaldi M., Fallico, M., Lotery, A., Maugeri, A., Favara, G., Barchitta, M., Agodi, A., Russo, A., Longo, A., Bonfiglio, V., Avitabile, T., Marolo, P., Borrelli, E., Parisi, G., Cennamo, G., Furino, C., and Reibaldi, M.

Subjects
Vascular Endothelial Growth Factor A, medicine.medical_specialty, genetic structures, medicine.medical_treatment, Visual Acuity, Endothelial Growth Factors, Macular Edema, Dexamethasone, Cataract, Ophthalmology, Diabetes Mellitus, Humans, Medicine, In patient, Diabetic Retinopathy, business.industry, DEX, cataract surgery, Cataract surgery, Diabetic cataract, Bevacizumab, Anti–vascular endothelial growth factor therapy, Diabetic macular oedema, anti-VEGF, diabetic macular oedema, Meta-analysis, sense organs, Implant, business, medicine.drug
Abstract

Objective: to compare outcomes of cataract surgery combined with either anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy or dexamethasone implant (DEX) in patients with diabetic macular oedema (DMO). Methods: Pubmed and Embase databases were searched for studies reporting outcomes of diabetic cataract surgery combined with either anti-VEGF or DEX, with a follow-up ≥3 months. The primary outcome was the mean change in central macular thickness (CMT). Mean change in best corrected visual acuity (BCVA) was considered as a secondary outcome. The mean difference between baseline and post-treatment values (MD) with 95%-Confidence Interval (95%CI) was calculated and meta-analyses were performed. Results: ninteen studies were included, 8 in the DEX group and 11 in the anti-VEGF group. A significant reduction of macular thickness was shown in the DEX group at 3 months (MD = −98.35 µm; 95% CI, −147.15/−49.54), while mean CMT change was non-significant in the anti-VEGF group (MD = −21.61 µm; 95% CI, −59.46/16.24; test of group differences, P < 0.001). At 3 months, no difference in visual gain was found between the two groups (P = 0.13). Conclusions: in DMO patients, cataract surgery combined with DEX seems to provide better anatomical outcomes compared with cataract surgery combined with anti-VEGF therapy. However, our evidence was limited by significant heterogeneity. Randomised trials comparing these two different combined approaches are warranted.

Published
2021
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46. Urgent Vitrectomy with Vancomycin Infusion, Silicone Oil Endotamponade, and General Antibiotic Treatment in Multiple Cases of Endophthalmitis from a Single Day of Intravitreal Injections—Case Series

Author

Vincenza Bonfiglio, Ewa Jasińska, Robert Rejdak, Teresio Avitabile, Agata Pietras-Baczewska, Michele Reibaldi, Mario Damiano Toro, Katarzyna Nowomiejska, Pietras-Baczewska A., Jasinska E., Toro M.D., Bonfiglio V., Reibaldi M., Avitabile T., Nowomiejska K., Rejdak R., Pietras-Baczewska, A., Jasinska, E., Toro, M. D., Bonfiglio, V., Reibaldi, M., Avitabile, T., Nowomiejska, K., and Rejdak, R.

Subjects
medicine.medical_specialty, Visual acuity, genetic structures, medicine.medical_treatment, lcsh:Medicine, Vitrectomy, Bacterial endophthalmiti, Article, 03 medical and health sciences, 0302 clinical medicine, Endophthalmitis, Ophthalmology, medicine, post-injection endophthalmitis, 030212 general & internal medicine, Aflibercept, endophthalmitis treatment, business.industry, lcsh:R, bacterial endophthalmitis, General Medicine, Phacoemulsification, Macular degeneration, medicine.disease, Streptococcus mitis/oralis, eye diseases, 030221 ophthalmology & optometry, Vancomycin, Tamponade, Bacterial endophthalmitis, En-dophthalmitis treatment, Post-injection endophthalmitis, sense organs, medicine.symptom, Post-injection endophthalmiti, business, medicine.drug
Abstract

The aim of this study was to report on the anatomical and functional results of surgical management of seven cases of endophthalmitis related to a single day of intravitreal aflibercept injections. Patients with signs of endophthalmitis who underwent aflibercept injections (seven eyes) performed on the same day were retrospectively evaluated. The data of visual acuity and optical coherence tomography (OCT) within nine months of the follow-up and the treatment and results of microbiological cultures are reported. Four of the total seven cases had a positive bacterial culture outcome (Streptococcus mitis). All patients underwent vitrectomy combined with phacoemulsification when the eyes were not pseudophakic, vancomycin infusion, and silicone oil tamponade within 24 h, additionally, systemic antibiotics were administered intravenously. The final best-corrected visual acuity (BCVA) after the treatment was finger counting or light perception in all cases, and all eyes were saved with disruption of the inner retinal layers and stabilization of the retina in regard to changes related to the wet age-related macular degeneration (AMD). Although the retinal anatomy was mostly preserved, most of the patients affected by Streptococcus mitis-induced endophthalmitis did not regain baseline vision after the therapy.

Published
2021

47. Retinal Vascular Assessment in Psoriasis: A Multicenter Study

Author

Rosa Maria D’urso, Teresio Avitabile, Guglielmo Parisi, Niccolò Castellino, Francesco Lacarrubba, Andrea Russo, Giuseppe Micali, Gabriella Fabbrocini, Francesco Petrillo, Antonio Longo, Michele Reibaldi, Vincenza Bonfiglio, Maria Letizia Musumeci, Matteo Fallico, Gilda Cennamo, Anna Balato, Federica Fossataro, Pietro Alosi, Castellino N., Longo A., Fallico M., Russo A., Bonfiglio V., Cennamo G., Fossataro F., Fabbrocini G., Balato A., Parisi G., D'urso R.M., Lacarrubba F., Musumeci M.L., Alosi P., Petrillo F., Micali G., Avitabile T., Reibaldi M., Castellino, N., Longo, A., Fallico, M., Russo, A., Bonfiglio, V., Cennamo, G., Fossataro, F., Fabbrocini, G., Balato, A., Parisi, G., D'Urso, R. M., Lacarrubba, F., Musumeci, M. L., Alosi, P., Petrillo, F., Micali, G., Avitabile, T., and Reibaldi, M.

Subjects
retina, Intraocular pressure, medicine.medical_specialty, vascular changes, genetic structures, macula, optical coherence tomography angiography, psoriasis, lcsh:RC321-571, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, Psoriatic arthritis, 0302 clinical medicine, Ophthalmology, Psoriasis, Medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, psoriasi, Original Research, Retina, medicine.diagnostic_test, business.industry, General Neuroscience, Retinal, Optical coherence tomography angiography, medicine.disease, eye diseases, medicine.anatomical_structure, chemistry, Multicenter study, Eye examination, 030221 ophthalmology & optometry, sense organs, business, Neuroscience
Abstract

PurposeTo investigate the vascular status of the macula in psoriasis patients without history of ocular inflammation by Optical Coherence Tomography Angiography (OCTA).MethodsThis prospective cross-sectional multicenter study included 55 psoriasis patients and 55 control healthy subjects. A complete eye examination and 6 mm × 6 mm OCTA imaging were performed. Retinal vascular status was evaluated by analyzing vascular density (VD) of superficial vascular plexus (superficial wVD) and deep vascular plexuses (deep wVD) in a 6 mm × 6 mm area and in foveal (superficial fVD and deep fVD) and parafoveal sectors (superficial pVD and deep pVD). In addition, foveal thickness (FT) and foveal avascular zone (FAZ) and clinical variables, including best corrected visual acuity (BCVA), intraocular pressure and refractive condition, were collected.ResultsBCVA, intraocular pressure and refractive condition were comparable between cases and controls. OCTA imaging showed that superficial wVD and superficial pVD were lower in the psoriasis group in comparison with controls (p = 0.009 and p = 0.01, respectively). Similarly, deep wVD and pVD were lower in the psoriasis group in comparison with control subjects (p = 0.03 and p = 0.01, respectively). In a sub-analysis of 47 patients affected by psoriasis without psoriatic arthritis, lower values of wVD and pVD in both superficial and deep capillary plexuses were registered.ConclusionOCTA is a useful tool which provides data on vascular status of the retina in psoriasis with no ocular involvement. VD data may suggest that vascular changes may occur earlier than clinical onset of posterior inflammation.

Published
2021
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48. Intravitreal Dexamethasone Implant for Postoperative Macular Oedema Secondary to Vitrectomy for Epiretinal Membrane and Retinal Detachment: A Systematic Review and Meta-Analysis

Author

Guglielmo Parisi, Gilda Cennamo, Matteo Fallico, Paola Marolo, Francesco Petrillo, Andrea Russo, Vincenza Bonfiglio, Martina Barchitta, Teresio Avitabile, Antonio Longo, Paolo Caselgrandi, Luca Ventre, Andrea Maugeri, Michele Reibaldi, Claudio Furino, Elina Ortisi, Parisi, G., Fallico, M., Avitabile, T., Longo, A., Ortisi, E., Russo, A., Petrillo, F., Maugeri, A., Barchitta, M., Bonfiglio, V., Furino, C., Cennamo, G., Caselgrandi, P., Marolo, P., Ventre, L., Reibaldi, M., Parisi G., Fallico M., Avitabile T., Longo A., Ortisi E., Russo A., Petrillo F., Maugeri A., Barchitta M., Bonfiglio V., Furino C., Cennamo G., Caselgrandi P., Marolo P., Ventre L., and Reibaldi M.

Subjects
medicine.medical_specialty, Visual acuity, genetic structures, medicine.medical_treatment, Population, Vitrectomy, Review Article, law.invention, Randomized controlled trial, law, Ophthalmology, medicine, education, Dexamethasone, education.field_of_study, business.industry, Retinal detachment, RE1-994, medicine.disease, Confidence interval, macular oedema, intravitreal dexamethasone implant (DEX), vitrectomy, epiretinal membrane (ERM), retinal detachment (RD), Epiretinal membrane, medicine.symptom, business, medicine.drug
Abstract

Purpose. To evaluate the efficacy of intravitreal dexamethasone implant (DEX) for the treatment of macular oedema secondary to vitrectomy for epiretinal membrane (ERM) and retinal detachment (RD) by conducting a systematic review with meta-analysis of published studies. Methods. Studies reporting clinical outcomes of DEX use for the treatment of macular oedema secondary to ERM and RD vitrectomy were searched on PubMed and Embase databases. The primary outcome was best-corrected visual acuity (BCVA) change between baseline and post-DEX treatment, reported as mean difference (MD) with 95% confidence interval (CI). Mean central macular thickness (CMT) change was assessed as a secondary outcome. Postimplant adverse events, including intraocular pressure rise and cataract development, were reported as well. Results. Five uncontrolled studies, 1 nonrandomized controlled study, and 1 randomized controlled study were included, with a total of 5 cohorts and 3 cohorts in the ERM group and RD group, respectively. Considering the last available follow-up, a significant improvement in postimplant BCVA was found in the overall population, irrespective of the indication for vitrectomy (MD = −0.28, 95% CI = −0.37, −0.20; p < 0.001 ), but with significant heterogeneity. In either group, mean BCVA significantly improved following the implant (in the ERM group, MD = −0.31, 95% CI = −0.40, −0.22; in the RD group, MD = −0.22, 95% CI = −0.41, −0.03), with no difference between the two groups ( p = 0.41 ). However, there was significant heterogeneity in both groups. Considering the last available follow-up, a significant CMT reduction was found in the overall population, irrespective of the indication for vitrectomy (MD = −129.75, 95% CI = −157.49, −102.01; p < 0.001 ). In the ERM group, a significant CMT reduction was shown following DEX (MD = −133.41, 95% CI = −155.37, −111.45; p < 0.001 ), with no heterogeneity. In the RD group, mean CMT reduction was borderline significant (MD = −128.37, 95% CI = −253.57, −3.18; p = 0.040 ), with significant heterogeneity. No difference in CMT improvement was found between the two groups ( p = 0.94 ). Conclusion. This meta-analysis showed that DEX yielded a significant improvement in visual and anatomical outcomes, even if limited by significant heterogeneity. Dexamethasone implant represents an effective treatment for postoperative macular oedema secondary to ERM and RD vitrectomy.

Published
2021

49. Factors predicting normal visual acuity following anatomically successful macular hole surgery

Author

Michele Reibaldi, Mario Damiano Toro, Luca Ventre, Teresio Avitabile, Argyrios Chronopoulos, Mario R. Romano, Antonio Longo, Robert Rejdak, Marco Lupidi, Katarzyna Nowomiejska, Andrea Russo, Lorenzo Motta, Lars-Olof Hattenbach, Rino Frisina, Francesca Parisi, Carlo Cagini, Tito Fiore, Timothy L Jackson, Vincenza Bonfiglio, Matteo Fallico, Fallico M., Jackson T.L., Chronopoulos A., Hattenbach L.-O., Longo A., Bonfiglio V., Russo A., Avitabile T., Parisi F., Romano M., Fiore T., Cagini C., Lupidi M., Frisina R., Motta L., Rejdak R., Nowomiejska K., Toro M., Ventre L., Reibaldi M., Fallico, M, Jackson, Tl, Chronopoulos, A, Hattenbach, Lo, Longo, A, Bonfiglio, V, Russo, A, Avitabile, T, Parisi, F, Romano, M, Fiore, T, Cagini, C, Lupidi, M, Frisina, R, Motta, L, Rejdak, R, Nowomiejska, K, Toro, M, Ventre, L, and Reibaldi, M.

Subjects
Male, medicine.medical_specialty, Multivariate analysis, Visual acuity, genetic structures, Pseudophakia, macular hole closure, medicine.medical_treatment, Visual Acuity, vitrectomy, Vitrectomy, Time-to-Treatment, 03 medical and health sciences, 0302 clinical medicine, full-thickness macular hole, idiopathic macular hole, macular hole surgery, medicine, Full-thickness macular hole, Humans, Macular hole, Aged, Retrospective Studies, business.industry, General Medicine, Odds ratio, Cataract surgery, Middle Aged, medicine.disease, Retinal Perforations, eye diseases, Confidence interval, Surgery, Ophthalmology, Treatment Outcome, 030221 ophthalmology & optometry, Female, sense organs, medicine.symptom, business, 030217 neurology & neurosurgery, Tomography, Optical Coherence, Follow-Up Studies
Abstract

Purpose: To assess the incidence of normal vision following anatomically successful macular hole surgery and associated clinical variables. Methods: Multicentre, retrospective chart review. Preoperative, intraoperative and postoperative clinical data were extracted from electronic medical records from seven European vitreoretinal units. Inclusion criteria were as follows: eyes undergoing primary vitrectomy for idiopathic full-thickness macular hole from January 2015 to January 2018; postoperative macular hole closure confirmed by spectral domain optical coherence tomography (OCT); preoperative pseudophakia or phakic eyes receiving combined cataract surgery; one-year follow-up. The primary outcome was ‘normal vision’ defined as a final best-corrected visual acuity (BCVA) ≥ 20/25. Univariate, multivariate and decision-tree analyses were conducted to evaluate the clinical variables associated with ‘normal vision’. Odds ratios (OR) and confidence intervals (CIs) were calculated. Results: Of 327 eligible cases, 91 (27.8%) achieved ‘normal vision’ at 1year. Multivariate analysis identified variables significantly associated with ‘normal vision’: shorter symptom duration (odds ratio [OR]=1.05; 95% confidence interval [CI]:1.02-1.09; p=0.002), smaller preoperative OCT minimum linear diameter (OR per 100-micron increase=1.65; 95%CI:1.31-2.08; p&nbsp

Published
2021

50. Kinetic and static perimetry after 16 years and additional OCT-A analysis in eyes with long-lasting optic disc drusen

Author

Dominika Nowakowska, Robert Rejdak, Teresio Avitabile, Michele Reibaldi, Agnieszka Brzozowska, Edyta Koman-Wierdak, Katarzyna Nowomiejska, Mario Damiano Toro, Vincenza Bonfiglio, Koman-Wierdak, E., Nowomiejska, K., Brzozowska, A., Nowakowska, D., Toro, M. D., Bonfiglio, V., Reibaldi, M., Avitabile, T., Rejdak, R., Koman-Wierdak E., Nowomiejska K., Brzozowska A., Nowakowska D., Toro M.D., Bonfiglio V., Reibaldi M., Avitabile T., and Rejdak R.

Subjects
Male, Retinal Ganglion Cells, Fovea Centralis, genetic structures, chemistry.chemical_compound, Nerve Fibers, Animal Cells, Medicine and Health Sciences, Macula Lutea, Prospective Studies, Neurons, Multidisciplinary, Statistical Models, Optic Disk Drusen, Statistics, Angiography, Middle Aged, Optic disc drusen, Visual field, medicine.anatomical_structure, Physical Sciences, Optic nerve, Medicine, Female, Anatomy, Cellular Types, Tomography, Optical Coherence, Optic disc, Research Article, Long lasting, Adult, medicine.medical_specialty, Ocular Anatomy, Science, Optic Disk, Vision Disorders, Optic Disc, Young Adult, Ocular System, Ophthalmology, medicine, Humans, Aged, Plexus, business.industry, Fovea centralis, Biology and Life Sciences, Retinal Vessels, Retinal, Optic Nerve, Cell Biology, medicine.disease, eye diseases, Capillaries, chemistry, Cellular Neuroscience, Case-Control Studies, Cardiovascular Anatomy, Eyes, Blood Vessels, Visual Field Tests, sense organs, Visual Fields, business, Head, Mathematics, Neuroscience
Abstract

The aim of the study is to evaluate the progression of visual field (VF) defects over 16 years of observation and to assess abnormalities in vessels and retinal nerve fibre layer (RNFL) thickness in patients with optic disc drusen (ODD). Both static automated perimetry (SAP) and semi-automated kinetic perimetry (SKP) were performed in 16 eyes of 8 patients (mean age 54 years) with ODD among 26 eyes of 13 patients examined 16 years before. The area of I2e, I4e, III4e, and V4e isopters was measured in deg2. The MD and PSD parameters were estimated using SAP. Optical coherence tomography angiography (OCT-A) was additionally performed in 16 ODD eyes and 16 eyes of 8 healthy subjects to estimate the RNFL thickness and vessel density of the optic nerve disc and the macula. The differences in all isopter areas of SKP and SAP parameters after 16 years were not significant. The analysis of OCT-A showed a significant reduction of the vessel density and RNFL of the peripapillary area in each segment in patients with ODD, compared with the control group. The highest reduction of RNFL was observed in the superior segment of the optic disc area (92.56μm vs 126.63μm) also the macular thickness was decreased in ODD patients, compared with the control group. In the macula, there was a significant vascular defect in the whole superficial layer and in the parafoveal deep layer. A strong significant correlation of the parafoveal deep plexus with MD and PSD parameters was detected. In conclusion, VF loss due to ODD after 16 years of the follow-up was not significant both in SKP and SAP. ODD caused a reduced vessel density and RNFL, as well as macular thickness in OCT-A. SAP parameters were influenced by parafoveal deep plexus.

Published
2021

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