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Copper (II) phthalocyanine and 2,9,16,23 tetrakis nitro copper (II) phthalocyaninehas been synthesized respectively from phthalonitrile and 4-nitro phthalonitrile under solvent-free condition using two different catalystsovernanodimensionalzeolites. 4-Nitro phthalonitrile synthesized from phthalimide in three steps. The newly prepared compounds have been characterized by IR, UV-Vis, 1HNMR and MS spectra. [ABSTRACT FROM AUTHOR]

In this paper, we consider the current and potential role of the latest generation of Large Language Models (LLMs) in medical informatics, particularly within the realms of clinical and anatomic pathology. We aim to provide a thorough understanding of the considerations that arise when employing LLMs in healthcare settings, such as determining appropriate use cases and evaluating the advantages and limitations of these models. Furthermore, this paper will consider the infrastructural and organizational requirements necessary for the successful implementation and utilization of LLMs in healthcare environments. We will discuss the importance of addressing education, security, bias, and privacy concerns associated with LLMs in clinical informatics, as well as the need for a robust framework to overcome regulatory, compliance, and legal challenges., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)

Background: Serum free light chain (sFLC) assays are interpreted using a sFLC-ratio-based reference interval (manufacturer's interval) that was defined using a cohort of healthy patients. However, renal impairment elevates the sFLC-ratio, leading to a high false positive rate when using the manufacturer's interval. Prior studies have developed renal-specific reference intervals; however, this approach has not been widely adopted due to practical limitations. Thus, there remains a critical need for a renally robust sFLC interpretation method., Methods: Retrospective data mining was used to define patient cohorts that reflect the spectrum of renal function seen in clinical practice. Two new reference intervals, one based on the sFLC-ratio and one based on a novel principal component analysis (PCA)-based metric, were developed for the FREELITE assay (Binding Site) on the Roche Cobas c501 instrument (Roche)., Results: Compared to the manufacturer's reference interval, both new methods exhibited significantly lower false positive rates and greater robustness to renal function while maintaining equivalent sensitivity for monoclonal gammopathy (MG) diagnosis. While not significantly different, the point estimate for sensitivity was highest for the PCA-based approach., Conclusion: Renally robust sFLC interpretation using a single reference interval is possible given a reference cohort that reflects the variation in renal function observed in practice. Further studies are needed to achieve sufficient power and determine if the novel PCA-based metric offers superior sensitivity for MG diagnosis. These new methods offer the practical advantages of not requiring an estimated glomerular filtration rate result or multiple reference intervals, thereby lowering practical barriers to implementation., (© American Association for Clinical Chemistry 2023.)

In this study, a nonlinear robust control policy is designed together with a state observer in order to manage the novel coronavirus disease (COVID-19) outbreak having an uncertain epidemiological model with unmeasurable variables. This nonlinear model for the COVID-19 epidemic includes eight state variables (susceptible, exposed, infected, quarantined, hospitalized, recovered, deceased, and insusceptible populations). Two plausible scenarios are put forward in this article to control this epidemic before and after its vaccine invention. In the first scenario, the social distancing and hospitalization rates are employed as two applicable control inputs to diminish the exposed and infected groups. However, in the second scenario after the vaccine development, the vaccination rate is taken into account as the third control input to reduce the susceptible populations, in addition to the two objectives of the first scenario. The proposed feedback control measures are defined in terms of the hospitalized and deceased populations due to the available statistical data, while other unmeasurable compartmental variables are estimated by an extended Kalman filter (EKF). In other words, the susceptible, exposed, infected, quarantined, recovered, and insusceptible individuals cannot be identified precisely because of the asymptomatic infection of COVID-19 in some cases, its incubation period, and the lack of an adequate community screening. Utilizing the Lyapunov theorem, the stability and bounded tracking convergence of the closed-loop epidemiological system are investigated in the presence of modeling uncertainties. Finally, a comprehensive simulation study is conducted based on Canada's reported cases for two defined timing plans (with different treatment rates). Obtained results demonstrate that the developed EKF-based control scheme can achieve desired epidemic goals (exponential decrease of infected, exposed, and susceptible people)., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 Elsevier Ltd. All rights reserved.)

This paper introduces an extensive human motion data set for typical activities of daily living. These data are crucial for the design and control of prosthetic devices for transfemoral prosthesis users. This data set was collected from seven individuals, including five individuals with intact limbs and two transfemoral prosthesis users. These data include the following types of movements: (1) walking at three different speeds; (2) walking up and down a 5-degree ramp; (3) stepping up and down; (4) sitting down and standing up. We provide full-body marker trajectories and ground reaction forces (GRFs) as well as joint angles, joint velocities, joint torques, and joint powers. This data set is publicly available at the website referenced in this paper. Data from flexion and extension of the hip, knee, and ankle are presented in this paper. However, the data accompanying this paper (available on the internet) include 46 distinct measurements and can be useful for validating or generating mathematical models to simulate the gait of both transfemoral prosthesis users and individuals with intact legs., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2020 Seyed Fakoorian et al.)

Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section. To validate this platform, we used tissue microarrays containing 38 archival head and neck squamous cell carcinomas and revealed differential immune profiles based on lymphoid and myeloid cell densities, correlating with human papilloma virus status and prognosis. Based on these results, we investigated 24 pancreatic ductal adenocarcinomas from patients who received neoadjuvant GVAX vaccination and revealed that response to therapy correlated with degree of mono-myelocytic cell density and percentages of CD8 + T cells expressing T cell exhaustion markers. These data highlight the utility of in situ immune monitoring for patient stratification and provide digital image processing pipelines to the community for examining immune complexity in precious tissue sections, where phenotype and tissue architecture are preserved to improve biomarker discovery and assessment., (Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.)