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1. In situ estimation of ice crystal properties at the South Pole using LED calibration data from the IceCube Neutrino Observatory

Author: R. Abbasi, M. Ackermann, J. Adams, N. Aggarwal, J. Aguilar, M. Ahlers, M. Ahrens, J.-M. Alameddine, A. A. Alves Junior, N. M. B. Amin, K. Andeen, T. Anderson, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. Axani, X. Bai, A. Balagopal V, M. Baricevic, S. Barwick, V. Basu, R. Bay, J. Beatty, K. H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. Benda, S. BenZvi, D. Berley, E. Bernardini, D. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. Burley, R. Busse, M. Campana, E. Carnie-Bronca, C. Chen, Z. Chen, D. Chirkin, K. Choi, B. Clark, L. Classen, A. Coleman, G. Collin, A. Connolly, J. Conrad, P. Coppin, P. Correa, S. Countryman, D. Cowen, R. Cross, C. Dappen, P. Dave, C. De Clercq, J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, H. Dujmovic, M. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. Evenson, K. L. Fan, A. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, A. Fienberg, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glüsenkamp, T. Glauch, N. Goehlke, J. Gonzalez, S. Goswami, D. Grant, S. Gray, T. Grégoire, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, C. Hill, G. Hill, K. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jansson, G. Japaridze, M. Jeong, M. Jin, B. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. Kelley, A. Kheirandish, K. Kin, J. Kiryluk, S. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, E. Krupczak, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Larson, F. Lauber, J. Lazar, J. Lee, K. Leonard, A. Leszczyńska, M. Lincetto, Q. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, J. Micallef, D. Mockler, T. Montaruli, R. Moore, B. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, U. Naumann, A. Nayerhoda, J. Necker, M. Neumann, H. Niederhausen, M. Nisa, S. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O'Sullivan, H. Pandya, D. Pankova, N. Park, G. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, L. Peters, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, A. Porcelli, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. Przybylski, C. Raab, J. Rack-Helleis, M. Rameez, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, D. Rysewyk Cantu, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, C. Spannfellner, G. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. Sullivan, I. Taboada, S. Ter-Antonyan, W. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. Unland Elorrieta, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, S. Verpoest, D. Veske, C. Walck, W. Wang, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. Wiebusch, N. Willey, D. Williams, M. Wolf, G. Wrede, J. Wulff, X. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, S. Yu, T. Yuan, Z. Zhang, and P. Zhelnin
Subjects: Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract: The IceCube Neutrino Observatory instruments about 1 km3 of deep, glacial ice at the geographic South Pole. It uses 5160 photomultipliers to detect Cherenkov light emitted by charged relativistic particles. An unexpected light propagation effect observed by the experiment is an anisotropic attenuation, which is aligned with the local flow direction of the ice. We examine birefringent light propagation through the polycrystalline ice microstructure as a possible explanation for this effect. The predictions of a first-principles model developed for this purpose, in particular curved light trajectories resulting from asymmetric diffusion, provide a qualitatively good match to the main features of the data. This in turn allows us to deduce ice crystal properties. Since the wavelength of the detected light is short compared to the crystal size, these crystal properties include not only the crystal orientation fabric, but also the average crystal size and shape, as a function of depth. By adding small empirical corrections to this first-principles model, a quantitatively accurate description of the optical properties of the IceCube glacial ice is obtained. In this paper, we present the experimental signature of ice optical anisotropy observed in IceCube light-emitting diode (LED) calibration data, the theory and parameterization of the birefringence effect, the fitting procedures of these parameterizations to experimental data, and the inferred crystal properties.
Published: 2024
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2. Observation of seasonal variations of the flux of high-energy atmospheric neutrinos with IceCube

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, N. Aggarwal, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, C. Dappen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, S. Hauser, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jacquart, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Atmospheric muon neutrinos are produced by meson decays in cosmic-ray-induced air showers. The flux depends on meteorological quantities such as the air temperature, which affects the density of air. Competition between decay and re-interaction of those mesons in the first particle production generations gives rise to a higher neutrino flux when the air density in the stratosphere is lower, corresponding to a higher temperature. A measurement of a temperature dependence of the atmospheric $$\nu _{\mu }$$ ν μ flux provides a novel method for constraining hadronic interaction models of air showers. It is particularly sensitive to the production of kaons. Studying this temperature dependence for the first time requires a large sample of high-energy neutrinos as well as a detailed understanding of atmospheric properties. We report the significant ( $$> 10 \; \sigma $$ > 10 σ ) observation of a correlation between the rate of more than 260,000 neutrinos, detected by IceCube between 2012 and 2018, and atmospheric temperatures of the stratosphere, measured by the Atmospheric Infrared Sounder (AIRS) instrument aboard NASA’s AQUA satellite. For the observed 10 $$\%$$ % seasonal change of effective atmospheric temperature we measure a 3.5(3) $$\%$$ % change in the muon neutrino flux. This observed correlation deviates by about 2-3 standard deviations from the expected correlation of 4.3 $$\%$$ % as obtained from theoretical predictions under the assumption of various hadronic interaction models.
Published: 2023
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3. Erratum: 'Limits on Neutrino Emission from GRB 221009A from MeV to PeV Using the IceCube Neutrino Observatory' (2023, ApJL, 946, L26)

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, N. Aggarwal, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, C. Dappen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Astrophysics, QB460-466
Published: 2024
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4. Search for Joint Multimessenger Signals from Potential Galactic Cosmic-Ray Accelerators with HAWC and IceCube

Author: R. Alfaro, C. Alvarez, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, D. Depaoli, N. Di Lalla, R. Diaz Hernandez, J. C. Díaz-Vélez, K. Engel, T. Ergin, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. García-González, F. Garfias, M. M. González, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernández-Cadena, I. Herzog, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, S. Kaufmann, J. Lee, H. León Vargas, G. Luis-Raya, K. Malone, J. Martínez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, E. Moreno, M. Mostafá, L. Nellen, M. U. Nisa, N. Omodei, M. Osorio, Y. Pérez Araujo, E. G. Pérez-Pérez, C. D. Rho, D. Rosa-González, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, J. Serna-Franco, A. J. Smith, Y. Son, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, X. Wang, I. J. Watson, K. Whitaker, E. Willox, H. Wu, S. Yu, S. Yun-Cárcamo, H. Zhou, C. de León, HAWC Collaboration, R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, C. Argüelles, Y. Ashida, S. Athanasiadou, L. Ausborm, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, S. Bash, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, E. Blaufuss, L. Bloom, S. Blot, F. Bontempo, J. Y. Book Motzkin, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, J. Braun, B. Brinson, J. Brostean-Kaiser, L. Brusa, R. T. Burley, D. Butterfield, M. A. Campana, I. Caracas, K. Carloni, J. Carpio, S. Chattopadhyay, N. Chau, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, R. Corley, P. Correa, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, P. Dierichs, M. Dittmer, A. Domi, L. Draper, H. Dujmovic, K. Dutta, M. A. DuVernois, T. Ehrhardt, L. Eidenschink, A. Eimer, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, S. Fukami, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, M. Garcia, G. Garg, E. Genton, L. Gerhardt, A. Ghadimi, C. Girard-Carillo, C. Glaser, T. Glüsenkamp, J. G. Gonzalez, S. Goswami, A. Granados, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, C. Günther, P. Gutjahr, C. Ha, C. Haack, A. Hallgren, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, M. Handt, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, J. Häußler, K. Helbing, J. Hellrung, J. Hermannsgabner, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, M. Hostert, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, A. Ishihara, W. Iwakiri, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, N. Kamp, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, A. Katil, U. Katz, M. Kauer, J. L. Kelley, M. Khanal, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, J. Liao, M. Lincetto, Y. T. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, E. Magnus, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, L. Neste, M. Neumann, H. Niederhausen, K. Noda, A. Noell, A. Novikov, A. Obertacke Pollmann, V. O’Dell, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, T. Pernice, J. Peterson, S. Philippen, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, M. Ravn, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, A. Rosted, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, P. Sampathkumar, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, P. Schaile, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, S. Sclafani, D. Seckel, M. Seikh, M. Seo, S. Seunarine, P. Sevle Myhr, R. Shah, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, A. Terliuk, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, R. Turcotte, J. P. Twagirayezu, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, A. Vaidyanathan, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, A. Vijai, C. Walck, A. Wang, C. Weaver, P. Weigel, A. Weindl, J. Weldert, A. Y. Wen, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, D. R. Williams, L. Witthaus, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, T. Yuan, Z. Zhang, P. Zhelnin, P. Zilberman, M. Zimmerman, and IceCube Collaboration
Subjects: Neutrino astronomy, Gamma-ray astronomy, Particle astrophysics, High energy astrophysics, Astrophysics, QB460-466
Abstract: The origin of high-energy galactic cosmic rays is yet to be understood, but some galactic cosmic-ray accelerators can accelerate cosmic rays up to PeV energies. The high-energy cosmic rays are expected to interact with the surrounding material or radiation, resulting in the production of gamma-rays and neutrinos. To optimize for the detection of such associated production of gamma-rays and neutrinos for a given source morphology and spectrum, a multimessenger analysis that combines gamma-rays and neutrinos is required. In this study, we use the Multi-Mission Maximum Likelihood framework with IceCube Maximum Likelihood Analysis software and HAWC Accelerated Likelihood to search for a correlation between 22 known gamma-ray sources from the third HAWC gamma-ray catalog and 14 yr of IceCube track-like data. No significant neutrino emission from the direction of the HAWC sources was found. We report the best-fit gamma-ray model and 90% CL neutrino flux limit from the 22 sources. From the neutrino flux limit, we conclude that, for five of the sources, the gamma-ray emission observed by HAWC cannot be produced purely from hadronic interactions. We report the limit for the fraction of gamma-rays produced by hadronic interactions for these five sources.
Published: 2024
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5. Probing the Connection between IceCube Neutrinos and MOJAVE AGN

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, C. Argüelles, Y. Ashida, S. Athanasiadou, L. Ausborm, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, S. Bash, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, E. Blaufuss, L. Bloom, S. Blot, F. Bontempo, J. Y. Book Motzkin, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, J. Braun, B. Brinson, J. Brostean-Kaiser, L. Brusa, R. T. Burley, D. Butterfield, M. A. Campana, I. Caracas, K. Carloni, J. Carpio, S. Chattopadhyay, N. Chau, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, R. Corley, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, P. Dierichs, M. Dittmer, A. Domi, L. Draper, H. Dujmovic, D. Durnford, K. Dutta, M. A. DuVernois, T. Ehrhardt, L. Eidenschink, A. Eimer, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, S. Fukami, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, M. Garcia, G. Garg, E. Genton, L. Gerhardt, A. Ghadimi, C. Girard-Carillo, C. Glaser, T. Glüsenkamp, J. G. Gonzalez, S. Goswami, A. Granados, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, D. Guevel, C. Günther, P. Gutjahr, C. Ha, C. Haack, A. Hallgren, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, M. Handt, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, J. Häußler, K. Helbing, J. Hellrung, J. Hermannsgabner, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, M. Hostert, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, A. Ishihara, W. Iwakiri, M. Jacquart, S. Jain, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, N. Kamp, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, A. Katil, U. Katz, M. Kauer, J. L. Kelley, M. Khanal, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, J. Liao, M. Lincetto, Y. T. Liu, M. Liubarska, C. Love, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, E. Magnus, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, L. Neste, M. Neumann, H. Niederhausen, M. U. Nisa, K. Noda, A. Noell, A. Novikov, A. Obertacke Pollmann, V. O’Dell, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, V. Palusova, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, T. Pernice, J. Peterson, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, M. Ravn, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, A. Rosted, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, P. Schaile, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, S. Sclafani, D. Seckel, M. Seikh, M. Seo, S. Seunarine, P. Sevle Myhr, R. Shah, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, A. Terliuk, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, R. Turcotte, J. P. Twagirayezu, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, A. Vaidyanathan, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, F. Varsi, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Vergara Carrasco, S. Verpoest, D. Veske, A. Vijai, C. Walck, A. Wang, C. Weaver, P. Weigel, A. Weindl, J. Weldert, A. Y. Wen, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, D. R. Williams, L. Witthaus, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, P. Zilberman, and M. Zimmerman
Subjects: Neutrino astronomy, High energy astrophysics, Radio astronomy, Astrophysics, QB460-466
Abstract: Active galactic nuclei (AGN) are prime candidate sources of the high-energy, astrophysical neutrinos detected by IceCube. This is demonstrated by the real-time multimessenger detection of the blazar TXS 0506+056 and the recent evidence of neutrino emission from NGC 1068 from a separate time-averaged study. However, the production mechanism of the astrophysical neutrinos in AGN is not well established, which can be resolved via correlation studies with photon observations. For neutrinos produced due to photohadronic interactions in AGN, in addition to a correlation of neutrinos with high-energy photons, there would also be a correlation of neutrinos with photons emitted at radio wavelengths. In this work, we perform an in-depth stacking study of the correlation between 15 GHz radio observations of AGN reported in the MOJAVE XV catalog, and 10 yr of neutrino data from IceCube. We also use a time-dependent approach, which improves the statistical power of the stacking analysis. No significant correlation was found for both analyses, and upper limits are reported. When compared to the IceCube diffuse flux, at 100 TeV and for a spectral index of 2.5, the upper limits derived are ∼3% and ∼9% for the time-averaged and time-dependent cases, respectively.
Published: 2024
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6. Erratum: 'A Search for IceCube Sub-TeV Neutrinos Correlated with Gravitational-wave Events Detected By LIGO/Virgo' (2023, ApJ, 959, 96)

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, F. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and The IceCube Collaboration
Subjects: Astrophysics, QB460-466
Published: 2024
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7. Erratum: 'Search for 10–1000 GeV Neutrinos from Gamma-Ray Bursts with IceCube' (2024, ApJ, 964, 126)

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, L. Ausborm, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, J. Braun, B. Brinson, J. Brostean-Kaiser, L. Brusa, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, A. Eimer, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, J. G. Gonzalez, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, C. Günther, P. Gutjahr, C. Ha, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, M. Handt, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, J. Häußler, K. Helbing, J. Hellrung, J. Hermannsgabner, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, N. Kamp, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, A. Katil, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Y. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, E. Magnus, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, A. Novikov, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, A. Rosted, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, S. Sclafani, D. Seckel, M. Seikh, S. Seunarine, R. Shah, S. Shefali, N. Shimizu, C. Silva, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, A. Vaidyanathan, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, A. Vijai, C. Walck, Y. Wang, C. Weaver, P. Weigel, A. Weindl, J. Weldert, A. Y. Wen, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, D. R. Williams, L. Witthaus, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, P. Zilberman, M. Zimmerman, and IceCube Collaboration
Subjects: Astrophysics, QB460-466
Published: 2024
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8. Erratum: 'Search for sub-TeV Neutrino Emission from Novae with IceCube-DeepCore' (2023, ApJ, 953, 160)

Author: R. Abbasi, M. Ackermann, J. Adams, N. Aggarwal, J. A. Aguilar, M. Ahlers, J. M. Alameddine, A. A. Alves Jr., N. M. Amin, K. Andeen, T. Anderson, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, M. A. Campana, E. G. Carnie-Bronca, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, C. Dappen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, A. T. Fienberg, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, T. Grégoire, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, U. Naumann, A. Nayerhoda, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, D. V. Pankova, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, D. Rysewyk Cantu, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Astrophysics, QB460-466
Published: 2024
Full Text: View/download PDF

9. All-sky Search for Transient Astrophysical Neutrino Emission with 10 Years of IceCube Cascade Events

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, L. Ausborm, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, J. Braun, B. Brinson, J. Brostean-Kaiser, L. Brusa, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, A. Eimer, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, J. G. Gonzalez, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, C. Günther, P. Gutjahr, C. Ha, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, M. Handt, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, J. Häußler, K. Helbing, J. Hellrung, J. Hermannsgabner, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, N. Kamp, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, A. Katil, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Y. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, E. Magnus, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, A. Novikov, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, A. Rosted, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, S. Sclafani, D. Seckel, M. Seikh, S. Seunarine, R. Shah, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, A. Vaidyanathan, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, A. Vijai, C. Walck, Y. Wang, C. Weaver, P. Weigel, A. Weindl, J. Weldert, A. Y. Wen, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, D. R. Williams, L. Witthaus, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, P. Zilberman, M. Zimmerman, and IceCube Collaboration
Subjects: Neutrino astronomy, High energy astrophysics, Transient sources, Astrophysics, QB460-466
Abstract: Neutrino flares in the sky are searched for in data collected by IceCube between 2011 and 2021 May. This data set contains cascade-like events originating from charged-current electron neutrino and tau neutrino interactions and all-flavor neutral-current interactions. IceCube’s previous all-sky searches for neutrino flares used data sets consisting of track-like events originating from charged-current muon neutrino interactions. The cascade data set is statistically independent of the track data sets, and while inferior in angular resolution, the low-background nature makes it competitive and complementary to previous searches. No statistically significant flare of neutrino emission was observed in an all-sky scan. Upper limits are calculated on neutrino flares of varying duration from 1 hr to 100 days. Furthermore, constraints on the contribution of these flares to the diffuse astrophysical neutrino flux are presented, showing that multiple unresolved transient sources may contribute to the diffuse astrophysical neutrino flux.
Published: 2024
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10. Erratum: 'IceCat-1: The IceCube Event Catalog of Alert Tracks' (2023, ApJS, 269, 25)

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V, M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, H. Dembinski, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, F. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, R. Shah, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, and P. Zhelnin
Subjects: Astrophysics, QB460-466
Published: 2024
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11. Search for 10–1000 GeV Neutrinos from Gamma-Ray Bursts with IceCube

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, L. Ausborm, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, J. Braun, B. Brinson, J. Brostean-Kaiser, L. Brusa, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, A. Eimer, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, J. G. Gonzalez, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, C. Günther, P. Gutjahr, C. Ha, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, M. Handt, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, J. Häußler, K. Helbing, J. Hellrung, J. Hermannsgabner, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, N. Kamp, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, A. Katil, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Y. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, E. Magnus, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, A. Novikov, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, A. Rosted, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, S. Sclafani, D. Seckel, M. Seikh, S. Seunarine, R. Shah, S. Shefali, N. Shimizu, C. Silva, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, A. Vaidyanathan, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, A. Vijai, C. Walck, Y. Wang, C. Weaver, P. Weigel, A. Weindl, J. Weldert, A. Y. Wen, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, D. R. Williams, L. Witthaus, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, P. Zilberman, M. Zimmerman, and IceCube Collaboration
Subjects: Cosmological neutrinos, Gamma-ray bursts, Astrophysics, QB460-466
Abstract: We present the results of a search for 10–1000 GeV neutrinos from 2268 gamma-ray bursts (GRBs) over 8 yr of IceCube-DeepCore data. This work probes burst physics below the photosphere where electromagnetic radiation cannot escape. Neutrinos of tens of giga electronvolts are predicted in sub-photospheric collision of free-streaming neutrons with bulk-jet protons. In a first analysis, we searched for the most significant neutrino-GRB coincidence using six overlapping time windows centered on the prompt phase of each GRB. In a second analysis, we conducted a search for a group of GRBs, each individually too weak to be detectable, but potentially significant when combined. No evidence of neutrino emission is found for either analysis. The most significant neutrino coincidence is for Fermi-GBM GRB bn 140807500, with a p -value of 0.097 corrected for all trials. The binomial test used to search for a group of GRBs had a p -value of 0.65 after all trial corrections. The binomial test found a group consisting only of GRB bn 140807500 and no additional GRBs. The neutrino limits of this work complement those obtained by IceCube at tera electronvolt to peta electronvolt energies. We compare our findings for the large set of GRBs as well as GRB 221009A to the sub-photospheric neutron-proton collision model and find that GRB 221009A provides the most constraining limit on baryon loading. For a jet Lorentz factor of 300 (800), the baryon loading on GRB 221009A is lower than 3.85 (2.13) at a 90% confidence level.
Published: 2024
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12. Search for Continuous and Transient Neutrino Emission Associated with IceCube’s Highest-energy Tracks: An 11 yr Analysis

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, S. Coenders, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, A. Eimer, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, A. Fritz, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, N. Kamp, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, A. Katil, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, A. Novikov, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, M. Seikh, S. Seunarine, R. Shah, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, A. Vaidyanathan, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, A. Vijai, C. Walck, C. Weaver, P. Weigel, A. Weindl, J. Weldert, A. Y. Wen, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, D. R. Williams, L. Witthaus, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, P. Zilberman, M. Zimmerman, and IceCube Collaboration
Subjects: High energy astrophysics, Active galactic nuclei, Neutrino astronomy, Transient sources, Blazars, Astrophysics, QB460-466
Abstract: IceCube alert events are neutrinos with a moderate-to-high probability of having astrophysical origin. In this study, we analyze 11 yr of IceCube data and investigate 122 alert events and a selection of high-energy tracks detected between 2009 and the end of 2021. This high-energy event selection (alert events + high-energy tracks) has an average probability of ≥0.5 of being of astrophysical origin. We search for additional continuous and transient neutrino emission within the high-energy events’ error regions. We find no evidence for significant continuous neutrino emission from any of the alert event directions. The only locally significant neutrino emission is the transient emission associated with the blazar TXS 0506+056, with a local significance of 3 σ , which confirms previous IceCube studies. When correcting for 122 test positions, the global p -value is 0.156 and compatible with the background hypothesis. We constrain the total continuous flux emitted from all 122 test positions at 100 TeV to be below 1.2 × 10 ^−15 (TeV cm ^2 s) ^−1 at 90% confidence assuming an E ^−2 spectrum. This corresponds to 4.5% of IceCube’s astrophysical diffuse flux. Overall, we find no indication that alert events in general are linked to lower-energetic continuous or transient neutrino emission.
Published: 2024
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13. Search for Galactic Core-collapse Supernovae in a Decade of Data Taken with the IceCube Neutrino Observatory

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, A. Fritz, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, A. Novikov, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, M. Seikh, S. Seunarine, R. Shah, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, A. Vijai, C. Walck, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, F. Yu, S. Yu, T. Yuan, Z. Zhang, and P. Zhelnin
Subjects: Core-collapse supernovae, Supernova neutrinos, Neutrino telescopes, Astrophysics, QB460-466
Abstract: The IceCube Neutrino Observatory has been continuously taking data to search for ${ \mathcal O }(0.5\mbox{--}10)$ s long neutrino bursts since 2007. Even if a Galactic core-collapse supernova is optically obscured or collapses to a black hole instead of exploding, it will be detectable via the ${ \mathcal O }(10)$ MeV neutrino burst emitted during the collapse. We discuss a search for such events covering the time between 2008 April 17 and 2019 December 31. Considering the average data taking and analysis uptime of 91.7% after all selection cuts, this is equivalent to 10.735 yr of continuous data taking. In order to test the most conservative neutrino production scenario, the selection cuts were optimized for a model based on an 8.8 solar mass progenitor collapsing to an O–Ne–Mg core. Conservative assumptions on the effects of neutrino oscillations in the exploding star were made. The final selection cut was set to ensure that the probability to detect such a supernova within the Milky Way exceeds 99%. No such neutrino burst was found in the data after performing a blind analysis. Hence, a 90% C.L. upper limit on the rate of core-collapse supernovae out to distances of ≈25 kpc was determined to be 0.23 yr ^−1 . For the more distant Magellanic Clouds, only high neutrino luminosity supernovae will be detectable by IceCube, unless external information on the burst time is available. We determined a model-independent limit by parameterizing the dependence on the neutrino luminosity and the energy spectrum.
Published: 2024
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14. Constraining High-energy Neutrino Emission from Supernovae with IceCube

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jacquart, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, A. Stasik, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Neutrino astronomy, Core-collapse supernovae, Circumstellar matter, High-energy astrophysics, Astrophysics, QB460-466
Abstract: Core-collapse supernovae are a promising potential high-energy neutrino source class. We test for correlation between seven years of IceCube neutrino data and a catalog containing more than 1000 core-collapse supernovae of types IIn and IIP and a sample of stripped-envelope supernovae. We search both for neutrino emission from individual supernovae as well as for combined emission from the whole supernova sample, through a stacking analysis. No significant spatial or temporal correlation of neutrinos with the cataloged supernovae was found. All scenarios were tested against the background expectation and together yield an overall p -value of 93%; therefore, they show consistency with the background only. The derived upper limits on the total energy emitted in neutrinos are 1.7 × 10 ^48 erg for stripped-envelope supernovae, 2.8 × 10 ^48 erg for type IIP, and 1.3 × 10 ^49 erg for type IIn SNe, the latter disfavoring models with optimistic assumptions for neutrino production in interacting supernovae. We conclude that stripped-envelope supernovae and supernovae of type IIn do not contribute more than 14.6% and 33.9%, respectively, to the diffuse neutrino flux in the energy range of about [ 10 ^3 –10 ^5 ] GeV, assuming that the neutrino energy spectrum follows a power-law with an index of −2.5. Under the same assumption, we can only constrain the contribution of type IIP SNe to no more than 59.9%. Thus, core-collapse supernovae of types IIn and stripped-envelope supernovae can both be ruled out as the dominant source of the diffuse neutrino flux under the given assumptions.
Published: 2023
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15. Limits on Neutrino Emission from GRB 221009A from MeV to PeV Using the IceCube Neutrino Observatory

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, N. Aggarwal, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, C. Dappen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Neutrino telescopes, Gamma-ray bursts, Particle astrophysics, Astrophysics, QB460-466
Abstract: Gamma-ray bursts (GRBs) have long been considered a possible source of high-energy neutrinos. While no correlations have yet been detected between high-energy neutrinos and GRBs, the recent observation of GRB 221009A—the brightest GRB observed by Fermi-GBM to date and the first one to be observed above an energy of 10 TeV—provides a unique opportunity to test for hadronic emission. In this paper, we leverage the wide energy range of the IceCube Neutrino Observatory to search for neutrinos from GRB 221009A. We find no significant deviation from background expectation across event samples ranging from MeV to PeV energies, placing stringent upper limits on the neutrino emission from this source.
Published: 2023
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16. IceCat-1: The IceCube Event Catalog of Alert Tracks

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V, M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, H. Dembinski, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, F. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, R. Shah, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, and P. Zhelnin
Subjects: Neutrino astronomy, Astronomical methods, High energy astrophysics, Astrophysics, QB460-466
Abstract: We present a catalog of likely astrophysical neutrino track-like events from the IceCube Neutrino Observatory. IceCube began reporting likely astrophysical neutrinos in 2016, and this system was updated in 2019. The catalog presented here includes events that were reported in real time since 2019, as well as events identified in archival data samples starting from 2011. We report 275 neutrino events from two selection channels as the first entries in the catalog, the IceCube Event Catalog of Alert Tracks, which will see ongoing extensions with additional alerts. The Gold and Bronze alert channels respectively provide neutrino candidates with a 50% and 30% probability of being astrophysical, on average assuming an astrophysical neutrino power-law energy spectral index of 2.19. For each neutrino alert, we provide the reconstructed energy, direction, false-alarm rate, probability of being astrophysical in origin, and likelihood contours describing the spatial uncertainty in the alert's reconstructed location. We also investigate a directional correlation of these neutrino events with gamma-ray and X-ray catalogs, including 4FGL, 3HWC, TeVCat, and Swift-BAT.
Published: 2023
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17. A Search for IceCube Sub-TeV Neutrinos Correlated with Gravitational-wave Events Detected By LIGO/Virgo

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, F. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and The IceCube Collaboration
Subjects: Neutrino astronomy, Neutrino telescopes, Gravitational waves, Gravitational wave astronomy, Particle astrophysics, Astrophysics, QB460-466
Abstract: The LIGO/Virgo collaboration published the catalogs GWTC-1, GWTC-2.1, and GWTC-3 containing candidate gravitational-wave (GW) events detected during its runs O1, O2, and O3. These GW events can be possible sites of neutrino emission. In this paper, we present a search for neutrino counterparts of 90 GW candidates using IceCube DeepCore, the low-energy infill array of the IceCube Neutrino Observatory. The search is conducted using an unbinned maximum likelihood method, within a time window of 1000 s, and uses the spatial and timing information from the GW events. The neutrinos used for the search have energies ranging from a few GeV to several tens of TeV. We do not find any significant emission of neutrinos, and place upper limits on the flux and the isotropic-equivalent energy emitted in low-energy neutrinos. We also conduct a binomial test to search for source populations potentially contributing to neutrino emission. We report a nondetection of a significant neutrino-source population with this test.
Published: 2023
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18. Search for Extended Sources of Neutrino Emission in the Galactic Plane with IceCube

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, E. Ellinger, S. El Mentawi, D. Elsässer, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, A. Fritz, P. Fürst, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, K. M. Groth, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, J. Krishnamoorthi, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, J. Mitchell, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, A. Negi, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, A. Novikov, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, D. Rysewyk, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, N. Schmeisser, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, M. Seikh, S. Seunarine, R. Shah, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, A. Vijai, C. Walck, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, M. Zimmerman, and IceCube Collaboration
Subjects: Neutrino astronomy, Astrophysics, QB460-466
Abstract: The Galactic plane, harboring a diffuse neutrino flux, is a particularly interesting target in which to study potential cosmic-ray acceleration sites. Recent gamma-ray observations by HAWC and LHAASO have presented evidence for multiple Galactic sources that exhibit a spatially extended morphology and have energy spectra continuing beyond 100 TeV. A fraction of such emission could be produced by interactions of accelerated hadronic cosmic rays, resulting in an excess of high-energy neutrinos clustered near these regions. Using 10 years of IceCube data comprising track-like events that originate from charged-current muon neutrino interactions, we perform a dedicated search for extended neutrino sources in the Galaxy. We find no evidence for time-integrated neutrino emission from the potential extended sources studied in the Galactic plane. The most significant location, at 2.6 σ post-trials, is a 1.°7 sized region coincident with the unidentified TeV gamma-ray source 3HWC J1951+266. We provide strong constraints on hadronic emission from several regions in the galaxy.
Published: 2023
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19. Search for Correlations of High-energy Neutrinos Detected in IceCube with Radio-bright AGN and Gamma-Ray Emission from Blazars

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, C. Benning, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, N. Chau, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado, H. Dembinski, S. Deng, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, S. El Mentawi, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, K. Farrag, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, O. Gries, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, N. Heyer, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, S. Hori, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, A. Ishihara, M. Jacquart, O. Janik, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, S. Latseva, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, J. Madsen, K. B. M. Mahn, Y. Makino, E. Manao, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, Y. Merckx, L. Merten, J. Micallef, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, A. Pontén, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, A. Rifaie, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, L. Schlickmann, B. Schlüter, F. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, M. Seikh, S. Seunarine, R. Shah, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, P. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, M. Thiesmeyer, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, M. Vereecken, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, A. Wolf, M. Wolf, G. Wrede, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, R. Young, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Neutrino astronomy, Gamma-ray sources, Radio active galactic nuclei, Astrophysics, QB460-466
Abstract: The IceCube Neutrino Observatory sends realtime neutrino alerts with a high probability of being astrophysical in origin. We present a new method to correlate these events and possible candidate sources using 2089 blazars from the Fermi-LAT 4LAC-DR2 catalog and with 3413 active galactic nuclei (AGNs) from the Radio Fundamental Catalog. No statistically significant neutrino emission was found in any of the catalog searches. The result suggests that a small fraction,
Published: 2023
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20. Search for sub-TeV Neutrino Emission from Novae with IceCube-DeepCore

Author: R. Abbasi, M. Ackermann, J. Adams, N. Aggarwal, J. A. Aguilar, M. Ahlers, J. M. Alameddine, A. A. Alves Jr., N. M. Amin, K. Andeen, T. Anderson, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, J. Borowka, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, M. A. Campana, E. G. Carnie-Bronca, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, C. Dappen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, A. T. Fienberg, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, T. Grégoire, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jansson, G. S. Japaridze, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, U. Naumann, A. Nayerhoda, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, D. V. Pankova, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, D. Rysewyk Cantu, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Novae, High energy astrophysics, Neutrino astronomy, Neutrino telescopes, Astrophysics, QB460-466
Abstract: The understanding of novae, the thermonuclear eruptions on the surfaces of white dwarf stars in binaries, has recently undergone a major paradigm shift. Though the bolometric luminosity of novae was long thought to arise directly from photons supplied by the thermonuclear runaway, recent gigaelectronvolt (GeV) gamma-ray observations have supported the notion that a significant portion of the luminosity could come from radiative shocks. More recently, observations of novae have lent evidence that these shocks are acceleration sites for hadrons for at least some types of novae. In this scenario, a flux of neutrinos may accompany the observed gamma rays. As the gamma rays from most novae have only been observed up to a few GeV, novae have previously not been considered as targets for neutrino telescopes, which are most sensitive at and above teraelectronvolt (TeV) energies. Here, we present the first search for neutrinos from novae with energies between a few GeV and 10 TeV using IceCube-DeepCore, a densely instrumented region of the IceCube Neutrino Observatory with a reduced energy threshold. We search both for a correlation between gamma-ray and neutrino emission as well as between optical and neutrino emission from novae. We find no evidence for neutrino emission from the novae considered in this analysis and set upper limits for all gamma-ray detected novae.
Published: 2023
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21. A Search for Coincident Neutrino Emission from Fast Radio Bursts with Seven Years of IceCube Cascade Events

Author: R. Abbasi, M. Ackermann, J. Adams, S. K. Agarwalla, J. A. Aguilar, M. Ahlers, J. M. Alameddine, N. M. Amin, K. Andeen, G. Anton, C. Argüelles, Y. Ashida, S. Athanasiadou, S. N. Axani, X. Bai, A. Balagopal V., M. Baricevic, S. W. Barwick, V. Basu, R. Bay, J. J. Beatty, K.-H. Becker, J. Becker Tjus, J. Beise, C. Bellenghi, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, F. Bontempo, J. Y. Book, C. Boscolo Meneguolo, S. Böser, O. Botner, J. Böttcher, E. Bourbeau, J. Braun, B. Brinson, J. Brostean-Kaiser, R. T. Burley, R. S. Busse, D. Butterfield, M. A. Campana, K. Carloni, E. G. Carnie-Bronca, S. Chattopadhyay, C. Chen, Z. Chen, D. Chirkin, S. Choi, B. A. Clark, L. Classen, A. Coleman, G. H. Collin, A. Connolly, J. M. Conrad, P. Coppin, P. Correa, S. Countryman, D. F. Cowen, P. Dave, C. De Clercq, J. J. DeLaunay, D. Delgado López, H. Dembinski, K. Deoskar, A. Desai, P. Desiati, K. D. de Vries, G. de Wasseige, T. DeYoung, A. Diaz, J. C. Díaz-Vélez, M. Dittmer, A. Domi, H. Dujmovic, M. A. DuVernois, T. Ehrhardt, P. Eller, R. Engel, H. Erpenbeck, J. Evans, P. A. Evenson, K. L. Fan, K. Fang, A. R. Fazely, A. Fedynitch, N. Feigl, S. Fiedlschuster, C. Finley, L. Fischer, D. Fox, A. Franckowiak, E. Friedman, A. Fritz, P. Fürst, T. K. Gaisser, J. Gallagher, E. Ganster, A. Garcia, S. Garrappa, L. Gerhardt, A. Ghadimi, C. Glaser, T. Glauch, T. Glüsenkamp, N. Goehlke, J. G. Gonzalez, S. Goswami, D. Grant, S. J. Gray, S. Griffin, S. Griswold, C. Günther, P. Gutjahr, C. Haack, A. Hallgren, R. Halliday, L. Halve, F. Halzen, H. Hamdaoui, M. Ha Minh, K. Hanson, J. Hardin, A. A. Harnisch, P. Hatch, A. Haungs, K. Helbing, J. Hellrung, F. Henningsen, L. Heuermann, S. Hickford, A. Hidvegi, C. Hill, G. C. Hill, K. D. Hoffman, K. Hoshina, W. Hou, T. Huber, K. Hultqvist, M. Hünnefeld, R. Hussain, K. Hymon, S. In, N. Iovine, A. Ishihara, M. Jacquart, M. Jansson, G. S. Japaridze, K. Jayakumar, M. Jeong, M. Jin, B. J. P. Jones, D. Kang, W. Kang, X. Kang, A. Kappes, D. Kappesser, L. Kardum, T. Karg, M. Karl, A. Karle, U. Katz, M. Kauer, J. L. Kelley, A. Khatee Zathul, A. Kheirandish, K. Kin, J. Kiryluk, S. R. Klein, A. Kochocki, R. Koirala, H. Kolanoski, T. Kontrimas, L. Köpke, C. Kopper, D. J. Koskinen, P. Koundal, M. Kovacevich, M. Kowalski, T. Kozynets, K. Kruiswijk, E. Krupczak, A. Kumar, E. Kun, N. Kurahashi, N. Lad, C. Lagunas Gualda, M. Lamoureux, M. J. Larson, F. Lauber, J. P. Lazar, J. W. Lee, K. Leonard DeHolton, A. Leszczyńska, M. Lincetto, Q. R. Liu, M. Liubarska, E. Lohfink, C. Love, C. J. Lozano Mariscal, L. Lu, F. Lucarelli, A. Ludwig, W. Luszczak, Y. Lyu, W. Y. Ma, J. Madsen, K. B. M. Mahn, Y. Makino, S. Mancina, W. Marie Sainte, I. C. Mariş, S. Marka, Z. Marka, M. Marsee, I. Martinez-Soler, R. Maruyama, F. Mayhew, T. McElroy, F. McNally, J. V. Mead, K. Meagher, S. Mechbal, A. Medina, M. Meier, S. Meighen-Berger, Y. Merckx, L. Merten, J. Micallef, D. Mockler, T. Montaruli, R. W. Moore, Y. Morii, R. Morse, M. Moulai, T. Mukherjee, R. Naab, R. Nagai, M. Nakos, U. Naumann, J. Necker, M. Neumann, H. Niederhausen, M. U. Nisa, A. Noell, S. C. Nowicki, A. Obertacke Pollmann, V. O’Dell, M. Oehler, B. Oeyen, A. Olivas, R. Orsoe, J. Osborn, E. O’Sullivan, H. Pandya, N. Park, G. K. Parker, E. N. Paudel, L. Paul, C. Pérez de los Heros, J. Peterson, S. Philippen, S. Pieper, A. Pizzuto, M. Plum, Y. Popovych, M. Prado Rodriguez, B. Pries, R. Procter-Murphy, G. T. Przybylski, C. Raab, J. Rack-Helleis, K. Rawlins, Z. Rechav, A. Rehman, P. Reichherzer, G. Renzi, E. Resconi, S. Reusch, W. Rhode, M. Richman, B. Riedel, E. J. Roberts, S. Robertson, S. Rodan, G. Roellinghoff, M. Rongen, C. Rott, T. Ruhe, L. Ruohan, D. Ryckbosch, I. Safa, J. Saffer, D. Salazar-Gallegos, P. Sampathkumar, S. E. Sanchez Herrera, A. Sandrock, M. Santander, S. Sarkar, J. Savelberg, P. Savina, M. Schaufel, H. Schieler, S. Schindler, B. Schlüter, T. Schmidt, J. Schneider, F. G. Schröder, L. Schumacher, G. Schwefer, S. Sclafani, D. Seckel, S. Seunarine, A. Sharma, S. Shefali, N. Shimizu, M. Silva, B. Skrzypek, B. Smithers, R. Snihur, J. Soedingrekso, A. Søgaard, D. Soldin, G. Sommani, C. Spannfellner, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, R. Stein, T. Stezelberger, T. Stürwald, T. Stuttard, G. W. Sullivan, I. Taboada, S. Ter-Antonyan, W. G. Thompson, J. Thwaites, S. Tilav, K. Tollefson, C. Tönnis, S. Toscano, D. Tosi, A. Trettin, C. F. Tung, R. Turcotte, J. P. Twagirayezu, B. Ty, M. A. Unland Elorrieta, A. K. Upadhyay, K. Upshaw, N. Valtonen-Mattila, J. Vandenbroucke, N. van Eijndhoven, D. Vannerom, J. van Santen, J. Vara, J. Veitch-Michaelis, M. Venugopal, S. Verpoest, D. Veske, C. Walck, T. B. Watson, C. Weaver, P. Weigel, A. Weindl, J. Weldert, C. Wendt, J. Werthebach, M. Weyrauch, N. Whitehorn, C. H. Wiebusch, N. Willey, D. R. Williams, M. Wolf, G. Wrede, J. Wulff, X. W. Xu, J. P. Yanez, E. Yildizci, S. Yoshida, F. Yu, S. Yu, T. Yuan, Z. Zhang, P. Zhelnin, and IceCube Collaboration
Subjects: Neutrino astronomy, Radio transient sources, High energy astrophysics, Astrophysics, QB460-466
Abstract: This paper presents the results of a search for neutrinos that are spatially and temporally coincident with 22 unique, nonrepeating fast radio bursts (FRBs) and one repeating FRB (FRB 121102). FRBs are a rapidly growing class of Galactic and extragalactic astrophysical objects that are considered a potential source of high-energy neutrinos. The IceCube Neutrino Observatory’s previous FRB analyses have solely used track events. This search utilizes seven years of IceCube cascade events which are statistically independent of track events. This event selection allows probing of a longer range of extended timescales due to the low background rate. No statistically significant clustering of neutrinos was observed. Upper limits are set on the time-integrated neutrino flux emitted by FRBs for a range of extended time windows.
Published: 2023
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22. Farm Exposure as a Differential Risk Factor in ANCA-Associated Vasculitis.

Author: P Willeke, B Schlüter, C Sauerland, H Becker, S Reuter, A Jacobi, and H Schotte
Subjects: Medicine, Science
Abstract: OBJECTIVE:To investigate the association of farm exposure and the development of ANCA-associated vasculitis (AAV). METHODS:One hundred eighty-nine well defined patients with AAV (n = 119 with granulomatosis with polyangiitis [GPA], n = 48 with microscopic polyangiitis [MPA], n = 22 patients with eosinophilic granulomatosis with polyangiitis [EGPA]) and 190 controls (n = 119 patients with rheumatoid arthritis, n = 71 with large vessel vasculitis) were interrogated using a structured questionnaire. Factors investigated were occupation, farm exposure, contact to different livestock, participation in harvesting, residence next to a farm, MRSA status, and contact to domestic pets at disease onset or ever before. The odds ratio (OR) and 95% confidence interval [95%CI] were calculated for each item. RESULTS:Univariate analysis revealed a strong association of AAV with regular farm exposure; OR 3.44 [95%CI 1.43-8.27]. AAV was also associated with regular contact to cattle 4.30 (1.43-8.27), pigs 2.75 (1.12-6.75) and MRSA carriage 3.38 (1.11-10.3). This association was stronger in the subgroup of GPA patients. OR in this group for farm exposure was 4.97; [2.02-12.2], for cattle 6.71 [95% CI 2.19-20.7], for pigs 4.34 [1.75-10.9], and MRSA carriage 5.06 [1.62-15.8]). There was no significant association of MPA or EGPA with these parameters. CONCLUSION:A significant association between farm exposure or farm animal exposure and AAV especially in the subgroup of patients with GPA has been identified. This suggests that these entities are distinct and have different triggers for the immune process.
Published: 2015
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23. Functionalizable Silica-Based Micron-Sized Iron Oxide Particles for Cellular Magnetic Resonance Imaging

Author: Nathanael Raschzok, Carolin M. Langer, Christian Schmidt, Karl H. Lerche, Nils Billecke, Kerstin Nehls, Natalie B. Schlüter, Annekatrin Leder, Susanne Rohn, Martina T. Mogl, Lutz Lüdemann, Lars Stelter, Ulf K. Teichgräber, Peter Neuhaus, and Igor M. Sauer
Subjects: Medicine
Abstract: Cellular therapies require methods for noninvasive visualization of transplanted cells. Micron-sized iron oxide particles (MPIOs) generate a strong contrast in magnetic resonance imaging (MRI) and are therefore ideally suited as an intracellular contrast agent to image cells under clinical conditions. However, MPIOs were previously not applicable for clinical use. Here, we present the development and evaluation of silica-based micron-sized iron oxide particles (sMPIOs) with a functionalizable particle surface. Particles with magnetite content of >40% were composed using the sol-gel process. The particle surfaces were covered with COOH groups. Fluorescein, poly-l-lysine (PLL), and streptavidin (SA) were covalently attached. Monodisperse sMPIOs had an average size of 1.18 μm and an iron content of about 1.0 pg Fe/particle. Particle uptake, toxicity, and imaging studies were performed using HuH7 cells and human and rat hepatocytes. sMPIOs enabled rapid cellular labeling within 4 h of incubation; PLL-modified particles had the highest uptake. In T2*-weighted 3.0 T MRI, the detection threshold in agarose was 1,000 labeled cells, whereas in T1-weighted LAVA sequences, at least 10,000 cells were necessary to induce sufficient contrast. Labeling was stable and had no adverse effects on labeled cells. Silica is a biocompatible material that has been approved for clinical use. sMPIOs could therefore be suitable for future clinical applications in cellular MRI, especially in settings that require strong cellular contrast. Moreover, the particle surface provides the opportunity to create multifunctional particles for targeted delivery and diagnostics.
Published: 2013
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24. PODeST - Process Optimization and Development through Sustainability

Author: B. Schlüter, M. Kirchner, G. Selvakumar, and W. Blümke
Subjects: Engineering, Process management, Development (topology), business.industry, General Chemical Engineering, Sustainability, Process optimization, General Chemistry, business, Industrial and Manufacturing Engineering
Published: 2018
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25. A Comparison of Polysomnographic Variables between Adolescents with Polycystic Ovarian Syndrome and Healthy Controls

Author: Thomas Menke, Gideon de Sousa, B. Schlüter, E. Trowitzsch, Thomas Reinehr, and Werner Andler
Subjects: medicine.medical_specialty, Sleep Stages, Pediatrics, medicine.diagnostic_test, business.industry, Polysomnography, medicine.disease, Obesity, Sleep in non-human animals, respiratory tract diseases, Obstructive sleep apnea, Endocrinology, Internal medicine, medicine, Menarche, Risk factor, business, Hypopnea
Abstract: The prevalence of obstructive sleep apnea syndrome (OSAS) is clearly increased in adults with polycystic ovarian syndrome (PCOS). The symptoms of PCOS usually begin around menarche. However, data concerning polynotsomnographic variables in adolescents with PCOS are limited. As obesity is a well-known risk factor for OSAS, we aimed to analyze differences in polysomnographic variables between obese and extremely obese adolescents with PCOS and healthy, normal-weight, obese, and extremely obese controls. Methods: Sixteen obese and 17 extremely obese adolescents with PCOS, 18 normal-weight, 17 obese, and 13 extremely obese controls underwent polysomnonotgraphy to compare mean transcutaneous arterial oxygen saturation (Sat O2), apnea-index (AI), hypopnea- index (HI), apnea-hypopnea index (AHI), the absolute number of obstructive apneas (NOA), percentage sleep stages 3 and 4 of non REM-sleep (stages 3 & 4), percentage of REM-sleep (% REM), sleep-onset latency, and sleep efficiency. Results: We found no significant differences between the groups concerning AI, HI, AHI, NOA, and stages 3 & 4. Significant differnotences between the groups were found regarding Sat O2, % REM, sleep-onset latency, and sleep efficiency. Conclusions: Concerning the respiratory variables, adolescents with PCOS do not seem to differ from healthy controls regardless of weight status, but there seem to be differences in sleep architecture.
Published: 2010
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26. Autoimmuninduktion durch pegyliertes Interferon-alpha-2b in Korrelation zur Überlebenszeit bei Mittel- und Hochrisikomelanompatienten

Author: Stephan Grabbe, D. Nashan, B. Schlüter, Carmen Loquai, T. A. Luger, and H. W. Klötgen
Subjects: medicine.medical_specialty, Anti-nuclear antibody, business.industry, medicine.medical_treatment, Melanoma, Autoantibody, Retrospective cohort study, Dermatology, medicine.disease, medicine.disease_cause, Gastroenterology, Serology, Autoimmunity, Autoimmune thyroiditis, Internal medicine, Immunology, medicine, business, Adjuvant
Abstract: BACKGROUND: The appearance of autoimmunity in tumor patients seems to be associated with a better prognosis. The aim of this retrospective study was to detect autoimmunity under adjuvant treatment with pegylated interferon-alpha-2b and to determine a correlation between autoimmune induction and survival. PATIENTS AND METHODS: To detect autoimmunity clinical and serological parameters were examined in 25 patients with R0-resected histological proven stage Ib-IV melanoma before and every three months during an 18-month adjuvant treatment with 2 μg/kg pegylated interferon-alpha-2b given once a week. RESULTS: Under treatment 16 of 25 patients (64 %) developed autoantibodies. There was no significant difference regarding survival data in patients with or without induction of autoantibodies (31,6 versus 31,9 months). However, it is remarkable that all 6 patients developing a clinically significant autoimmune thyroiditis and/or specific antinuclear antibodies were still alive 36 months after treatment beginning, with two of these patients being in complete remission from stage IV melanoma, compared to a mean survival time of 26,73 months for the remaining patient group with physiological irrelevant positive antibodies (n = 10/16). CONCLUSIONS: In our cohort, the number of patients who developed autoimmunity under pegylated interferon-alpha-2b is significantly higher as published data of non-pegylated interferon-alpha. Nevertheless, the significance of specific autoimmune induction as a prognostic indicator for a disease controlling antitumor immune response still needs to be confirmed.
Published: 2008
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27. Functionalizable silica-based micron-sized iron oxide particles for cellular magnetic resonance imaging

Author: Nils Billecke, Nathanael Raschzok, Karl H Lerche, Igor M. Sauer, Ulf Teichgräber, Susanne Rohn, Lars Stelter, Carolin M. Langer, Lutz Lüdemann, Martina T. Mogl, Christian Schmidt, Peter Neuhaus, Kerstin Nehls, Natalie B Schlüter, and Annekatrin Leder
Subjects: Male, Streptavidin, Cell Survival, Dispersity, Biomedical Engineering, Iron oxide, Medizin, Contrast Media, lcsh:Medicine, Ferric Compounds, chemistry.chemical_compound, Animals, Humans, Polylysine, Particle Size, Fluorescein, Magnetite Nanoparticles, Cells, Cultured, Magnetite, Transplantation, Chemistry, lcsh:R, Cell Biology, Silicon Dioxide, Magnetic Resonance Imaging, Rats, Microscopy, Electron, Rats, Inbred Lew, Hepatocytes, Biophysics, Particle, Agarose, Particle size
Abstract: Cellular therapies require methods for noninvasive visualization of transplanted cells. Micron-sized iron oxide particles (MPIOs) generate a strong contrast in magnetic resonance imaging (MRI) and are therefore ideally suited as an intracellular contrast agent to image cells under clinical conditions. However, MPIOs were previously not applicable for clinical use. Here, we present the development and evaluation of silica-based micron-sized iron oxide particles (sMPIOs) with a functionalizable particle surface. Particles with magnetite content of >40% were composed using the sol-gel process. The particle surfaces were covered with COOH groups. Fluorescein, poly-l-lysine (PLL), and streptavidin (SA) were covalently attached. Monodisperse sMPIOs had an average size of 1.18 μm and an iron content of about 1.0 pg Fe/particle. Particle uptake, toxicity, and imaging studies were performed using HuH7 cells and human and rat hepatocytes. sMPIOs enabled rapid cellular labeling within 4 h of incubation; PLL-modified particles had the highest uptake. In T2*-weighted 3.0 T MRI, the detection threshold in agarose was 1,000 labeled cells, whereas in T1-weighted LAVA sequences, at least 10,000 cells were necessary to induce sufficient contrast. Labeling was stable and had no adverse effects on labeled cells. Silica is a biocompatible material that has been approved for clinical use. sMPIOs could therefore be suitable for future clinical applications in cellular MRI, especially in settings that require strong cellular contrast. Moreover, the particle surface provides the opportunity to create multifunctional particles for targeted delivery and diagnostics.
Published: 2013

28. Diagnostics and management of sleep-related respiratory disturbances in children with skeletal dysplasia caused by FGFR3 mutations (achondroplasia and hypochondroplasia)

Author: B, Schlüter, G, De Sousa, E, Trowitzsch, and W, Andler
Subjects: Male, Adolescent, Polysomnography, Snoring, Infant, Newborn, Infant, Achondroplasia, Adenoidectomy, Sleep Disorders, Intrinsic, Child, Preschool, Humans, Receptor, Fibroblast Growth Factor, Type 3, Female, Child, Tonsillectomy
Abstract: To evaluate the frequency of clinical indicators for sleep-related respiratory disturbances (SRD) and the polysomnographical manifestations of these disorders in children with skeletal dysplasia caused by FGFR3 mutations. From January 1990 to January 2009, 24 patients (22 achondroplasia, 2 hypochondroplasia; 13 boys, 11 girls; age 8 days to 15 years, median age 3.0 years) were examined, including a semi-structured interview, a clinical examination, and a polysomnographic sleep recording (65 polysomnographic sleep recordings (PSG) in 24 patients). We performed PSG in a subgroup of five patients before and after adenoidectomy (AT) and/or tonsilectomy (TE). Daytime symptoms suggestive of SRD (daytime somnolence, attention and concentration problems, behavioural problems, and pallor) were found in 4/24 patients (16.7%). Sleep-related symptoms (snoring, mouth breathing, cyanosis, observed apneas, excessive sweating, enuresis, problems of initiating and maintaining sleep) were present in 18/24 patients (75%). Prior to the first PSG, 11/24 patients (45.8%) had undergone AT, 1/24 (4.2%) TE, 2/24 (8.3%) adenotonsilectomy (ATE), 3/24 (12.5%) liquor drainage, and 6/24 (25%) a craniocervical decompression operation. Clinical examination prior to PSG revealed hypertrophied tonsils in 11/24 patients (45.8%), disturbed nasal breathing in 8/24 patients (33.3), and enlarged cervical lymph nodes as a sign of chronic tonsillitis in 5/24 patients (20.8%). PSG findings were abnormal in 19/24 patients (79.2%) with a nadir of oxygen saturation (pulse oximetry) below 90% and/or a nadir of transcutaneous partial pressure of oxygen below 45 mmHg. Pathologic PSG findings were found in 10/24 patients (41.7%): obstructive sleep apnea syndrome (OSAS) was diagnosed in 8/24 patients (33.3%), central sleep apnea syndrome in 1/24 patients (4.2%), and hypoventilation in 1/24 patients (4.2%). As a consequence, the following therapeutic interventions were performed: AT in 1/24 patients (4.2%), TE in 2/24 (8.3%), ATE in 2/24 (8.3%), and nasal continuous positive airway pressure (continuous positive airway pressure) and bilevel positive airway pressure therapy (bilevel positive airway pressure), respectively, in 3/24 patients(12.5%). SRD, especially OSAS, represent a complication of clinical and prognostic relevance in children with achondroplasia. We therefore think that not only those children with a history suggestive of SRD, but all achondroplastic children should be evaluated by PSG. At least in a part of these patients, the pathophysiological mechanisms of OSAS are connected with the etiology of achondroplasia. Achondroplastic children with OSAS, who do not benefit from AT and/or TE, should be treated with NCPAP therapy.
Published: 2011

29. [Sleep problems in childhood: basis of sleep regulation and intervention possibilities]

Author: B, Schlüter
Subjects: Sleep Wake Disorders, Humans, Child
Abstract: In the article there is provided the up-to-date information about fundamentals of sleep regulation in childhood, sleep disturbances and treatment possibilities as well.
Published: 2008

30. Polysomnographic recordings of respiratory disturbances in Rett syndrome

Author: G. Aguigah, D. Buschatz, B. Schlüter, F. Aksu, and E. Trowitzsch
Subjects: Cognitive Neuroscience, Rett syndrome, General Medicine, medicine.disease, Sleep in non-human animals, respiratory tract diseases, Behavioral Neuroscience, Hypocapnia, Anesthesia, Hyperventilation, medicine, Breathing, Respiratory disturbances, medicine.symptom, Psychology
Abstract: Polygraphic recordings in the awake state and during sleep were performed in two girls with Rett syndrome, aged 9 y and 17 y, in order to characterize the clinically manifest breathing disorder of these patients. Primary hyperventilation was detected, leading to hypocapnia and compensatory apnoea. Hypoxaemia occurred as the consequence of prolonged apnoea. In the younger patient these disturbances were observed only in the awake state, whereas in the older patient they were found in the awake state and during sleep.
Published: 1995

31. Clinical and immunological characteristics of patients with Sjögren's syndrome in relation to α-fodrin antibodies.

Author: B. Schlüter
Subjects: *ENZYME-linked immunosorbent assay, *TUMOR necrosis factors, *SERUM, *LYMPHOCYTES
Abstract: Objectives. To analyse the prevalence of α-fodrin antibodies in patients with primary (pSS) and secondary Sjögren's syndrome (sSS) and the relation to clinical, serological and immunological features.Methods. Serum IgA and IgG antibodies to the 120 kDa α-fodrin were determined by ELISA technique in 62 pSS patients and 28 sSS patients. Results were correlated with clinical symptoms and laboratory findings as well as with the HLA-DR genotype. Additionally, antibody concentrations were correlated with the numbers of peripheral blood mononuclear cells (PBMCs) secreting interleukin (IL)-6, IL-10, interferon-γ (INF)-γ, and tumour necrosis factor-α determined by ELISPOT analysis. Lymphocytes and monocytes were examined flow-cytometrically for the expression of activation markers. Healthy age- and sex-matched volunteers served as controls.Results. The sensitivity of IgA and IgG α-fodrin antibodies was 35 and 31%, respectively, in pSS patients. In sSS patients, the sensitivity was 29 and 21%, respectively. In pSS patients with IgG antibodies, recurrent parotid swelling was significantly more prevalent. Also the number of INF-γ secreting PBMCs and the percentage of CD4/CD71+ lymphocytes as well as CD14/HLA-DR+ monocytes were significantly increased in this group compared with α-fodrin-negative patients or with controls. Interestingly, these patients also had a shorter disease duration. No association of α-fodrin antibodies with the HLA-DR genotype was found.Conclusion. Due to the low prevalence, serum antibodies to α-fodrin turned out to be of limited diagnostic value in our study. However, our data suggest that IgG antibodies to α-fodrin are indicative of clinical and immunological activity in pSS especially in patients with shorter disease duration and may thus serve as a marker of disease activity. [ABSTRACT FROM AUTHOR]
Published: 2007

32. Long-term treatment with etanercept significantly reduces the number of proinflammatory cytokine-secreting peripheral blood mononuclear cells in patients with rheumatoid arthritis.

Author: B. Schlüter
Published: 2004

33. Physiological and Anatomical Adaptations by Young Astrocaryum jauari Mart. (Arecaceae) in Periodically Inundated Biotopes of Central Amazonia

Author: Carlos Alfredo Joly, Bodo Furch, and Ursula B. Schlüter
Subjects: biology, Astrocaryum jauari, food and beverages, Plant physiology, Arecaceae, Photosynthesis, biology.organism_classification, Aerenchyma, Astrocaryum, chemistry.chemical_compound, chemistry, Chlorophyll, Botany, Ecology, Evolution, Behavior and Systematics, Woody plant
Abstract: Young plants of the palm, Astrocaryum jauari, are well-adapted anatomically and physiologically to hypoxic conditions. Annual inundation for as long as 300 days, at water temperatures of 28?C, produce neither leaf loss nor rotting of the roots. At a depth of 1.2 m beneath blackwaters, the leaves in the crowns of the plants show little decrease in the amount of chlorophyll. In contrast, submersion to an equal depth in whitewater produces a loss of chlorophyll. Photosynthetic oxygen production decreases to less than 30 percent of the terrestrial rate in plants submerged beneath blackwater, and to less than 10 percent in plants submerged in whitewater. Ethanol production compensates for temporary energy deficits. Respiration by the roots is greatly reduced but does not cease during inundation. Welldeveloped aerenchyma permits gas transport from the branches to the roots. A cylinder of stone cells and sclerenchyma fibers in the outer periphery of the primary bark prevents the collapse of the root aerenchyma due to reduced pressure within the roots and increasing external pressure as water depth rises.
Published: 1993
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34. Leukotriene generation and metabolism in isolated human lung macrophages

Author: W, Schönfeld, B, Schlüter, R, Hilger, and W, König
Subjects: Lung Neoplasms, Macrophages, hemic and immune systems, respiratory system, Immunoglobulin E, Leukotriene B4, respiratory tract diseases, Antibodies, Anti-Idiotypic, Carcinoma, Bronchogenic, Humans, lipids (amino acids, peptides, and proteins), SRS-A, Lung, Calcimycin, Cells, Cultured, Research Article
Abstract: We studied the generation and metabolism of leukotrienes (LTs) in human lung macrophages obtained from lung tissue of patients with central bronchial carcinoma. By counterflow centrifugation macrophages were enriched with a purity of more than 95-100%. A time and dose dependent generation of LTB4 and LTC4 was determined by specific radioimmunoassays after stimulation with the Ca-ionophore and anti-IgE. The amount of LTB4 exceeded the amount of LTC4. The concentrations of leukotrienes in the macrophage fraction amounted to 4.3 +/- 2.2 ng LTB4 and 0.6 +/- 0.05 ng LTC4/1 x 10(7) cells after 5 min of incubation with the Ca-ionophore. The LTB4 levels decreased to 3.0 +/- 0.6 ng after 60 min indicating the metabolism of the generated LTB4 by human lung macrophages. This was confirmed by incubation of the cells with exogenously added [3H]LTB4. LTB4 was converted into unpolar products as was identified by thin-layer chromatography and high-performance liquid chromatography; a comparison with the fibroblast cell line L929 which is known to convert LTB4 into the dihydro-LTB4 metabolite (5,12-dihydroxyeicosatrienoic acid) indicates that human lung macrophages use the same pathway of metabolization. Biological inactivation as determined by chemotaxis and cross-reaction with the LTB4 antiserum correlates with the degree of LTB4 metabolism. Moreover, the macrophages convert LTC4 into LTD4 and LTE4 by the enzymatic activity of the gamma-glutamyltranspeptidase and dipeptidase. Our data emphasize that the human alveolar macrophage not only produces arachidonic acid metabolites but modulates the local inflammatory potential by its metabolizing capacity for leukotrienes.
Published: 1988

35. Case report: Clinical, genetic and immunological characterization of a novel XK variant in a patient with McLeod syndrome.

Author: Dambietz CA, Doescher A, Heming M, Schirmacher A, Schlüter B, Schulte-Mecklenbeck A, Thomas C, Wiendl H, Meyer Zu Hörste G, and Wiethoff S
Abstract: Introduction: Pathogenic variants in the XK gene are associated with dysfunction or loss of XK protein leading to McLeod syndrome (MLS), a rare X-linked neuroacanthocytosis syndrome with multisystemic manifestation. Here we present clinical, genetic and immunological data on a patient originally admitted to our clinic for presumed post-COVID-19 syndrome, where thorough clinical work-up revealed a novel frameshift deletion in XK causal for the underlying phenotype. We additionally review the clinicogenetic spectrum of reported McLeod cases in the literature. Methods: We performed in-depth clinical characterization and flow cytometry of cerebrospinal fluid (CSF) in a patient where multi-gene panel sequencing identified a novel hemizygous frameshift deletion in XK . Additionally, Kell (K) and Cellano (k) antigen expression was analysed by Fluorescence-activated Cell Sorting (FACS). KEL gene expression was examined by RNA sequencing. Results: A novel hemizygous frameshift deletion in the XK gene resulting in premature termination of the amino acid chain was identified in a 46-year old male presenting with decrease in physical performance and persisting fatigue after COVID-19 infection. Examinations showed raised creatine kinase (CK) levels, neuropathy and clinical features of myopathy. FACS revealed the K-k+ blood type and reduced Cellano density. CSF flow cytometry showed elevation of activated T Cells. Conclusion: In-depth clinical, genetic, immunological and ribonucleic acid (RNA) expression data revealed axonal neuropathy, myopathy and raised levels of activated CSF-T-lymphocytes in a patient with a previously unpublished frameshift deletion in the XK gene., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Dambietz, Doescher, Heming, Schirmacher, Schlüter, Schulte-Mecklenbeck, Thomas, Wiendl, Meyer zu Hörste and Wiethoff.)
Published: 2024
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36. A novel serum calprotectin (MRP8/14) particle-enhanced immuno-turbidimetric assay (sCAL turbo) helps to differentiate systemic juvenile idiopathic arthritis from other diseases in routine clinical laboratory settings.

Author: Foell D, Saers M, Park C, Brix N, Glerup M, Kessel C, Wittkowski H, Hinze C, Berntson L, Fasth A, Myrup C, Nordal E, Rygg M, Hasle H, Albertsen BK, Herlin T, Holzinger D, Niederberger C, and Schlüter B
Abstract: Background: Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We have recently validated the complex of myeloid-related proteins 8/14 (MRP8/14, also known as S100A8/A9 complex or serum calprotectin) as a helpful biomarker supporting the diagnosis of SJIA. The results were subsequently confirmed with a commercial ELISA. However, further optimization of the analytical technology is important to ensure its feasibility for large-scale use in routine laboratory settings., Methods: To evaluate the accuracy in identifying children with SJIA, the performance of a particle-enhanced immuno-turbidimetric assay for serum calprotectin (sCAL turbo) on an automated laboratory instrument was analyzed. Samples from 615 children were available with the diagnoses SJIA (n = 99), non-systemic JIA (n = 169), infections (n = 51), other inflammatory diseases (n = 126), and acute lymphoblastic leukemia (ALL, n = 147). In addition, samples from 23 healthy controls were included., Results: The sCAL turbo assay correlated well with the MRP8/14 ELISA used in previous validation studies (r = 0.99, p < 0.001). It could reliably differentiate SJIA from all other diagnoses with significant accuracy (cutoff at 10,500 ng/ml, sensitivity 84%, specificity 94%, ROC area under curve 0.960, p < 0.001)., Conclusions: Serum calprotectin analyses are a helpful tool supporting the diagnosis of SJIA in children with prolonged fever or inflammatory disease. Here, we show that an immuno-turbidimetric assay for detection of serum calprotectin on an automated laboratory instrument can be implemented in clinical laboratory settings to facilitate its use as a diagnostic routine test in clinical practice., (© 2023. Springer Nature Switzerland AG.)
Published: 2023
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37. Influence of Graphene Type and Content on Friction and Wear of Silicon Carbide/Graphene Nanocomposites in Aqueous Environment.

Author: Schlüter B, Schröder C, Zhang W, Mülhaupt R, Degenhardt U, Sedlák R, Dusza J, Balázsi K, Balázsi C, and Kailer A
Abstract: Two different types of graphene materials were used as functional nanofillers for the mechanical and tribological improvement of silicon carbide/graphene nanocomposites. On the one hand is thermally reduced graphite oxide (TRGO) reduced at three different temperatures, and on the other hand is graphene made of three different organic precursors, which were directly coated on silicon carbide (SiC) platelets (GSiC). Additionally, benchmark materials were also used as carbon fillers. The SiC/graphene nanocomposites with 2 wt% filler content were manufactured by pressureless sintering (PLS). Some composites were produced with higher graphene contents of 4% and 8% and sintered by spark plasma sintering (SPS). Microstructural analyses were conducted using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Underwater lubrication, the SP sintered TRGO and GSiC materials with high graphene content have shown the most promising tribological performance. Furthermore, the reduced size of the homogeneously distributed nanoparticles promotes the formation of surface states, which improve the friction and wear properties.
Published: 2022
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38. Laser Structuring and DLC Coating of Elastomers for High Performance Applications.

Author: Vogel S, Brenner A, Schlüter B, Blug B, Kirsch F, and van Roo T
Abstract: Even though hard, low friction coatings such as diamond like carbon (DLC) would be beneficial for the performance and longevity of rubber seals, a crucial challenge remains. The elastic mismatch of rubber substrate and DLC coating prevents a fracture free coating application. In this work, a nature inspired approach is applied to render the stiff coating flexible and resilient to delamination at the same time by direct patterning. Rubber substrates were laser structured with tile patterns and subsequently DLC coated. Tensile and tribology tests were performed on structured and unstructured samples. Unstructured DLC coatings showed a crack pattern induced by the coating process, which was further fragmented by tensile stress. Coatings with tile patterns did not experience a further fragmentation under load. During continuous tribological loading, less heterogenous damage is produced for tile structured samples. The findings are ascribed to the relief of induced coating stress by the tile structure, meaning a more resilient coating.
Published: 2022
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39. Prevalence of autoantibodies in patients with juvenile idiopathic arthritis: results from the German inception cohort ICON-JIA.

Author: Schulz C, Fuehner S, Schlüter B, Fobker M, Sengler C, Klotsche J, Niewerth M, Minden K, and Foell D
Subjects: Adolescent, Child, Female, Germany, Humans, Longitudinal Studies, Male, Prevalence, Prospective Studies, Arthritis, Juvenile blood, Arthritis, Juvenile immunology, Autoantibodies blood
Abstract: Background: An association of different autoimmune diseases is suspected. In juvenile idiopathic arthritis (JIA), only few and partially conflicting data on the co-existence of other autoimmune disorders are available. The prevalence of autoantibodies in patients with JIA in Germany is not known., Methods: Samples from 499 patients (median age at time of blood collection 11 years, median disease duration 4.4 years) in the prospective, multicenter inception cohort of children newly diagnosed with JIA (ICON-JIA) were analysed for the presence of anti-thyroid antibodies, celiac disease-specific antibodies (anti-tTG IgA, anti-tTG IgG), and connective tissue disease-associated antibodies (CTD-screen)., Results: A total of 76 (15.2%) patients had either clinically diagnosed autoimmune comorbidity or elevated autoantibodies. Of 21 patients with clinical autoimmune comorbidity, only 8 were also serologically positive at the time of testing, while 55 patients had autoantibodies without clinical diagnosis. Thus, 63 patients (12.6%) had at least one elevated autoantibody. Antibodies against thyroglobulin were found in 3% and against thyreoperoxidase in 4% of the samples. TSH receptor antibodies could not be detected in any of the 499 patients. Tissue transglutaminase antibodies were elevated in 0.4% of the patients. A positive screen for CTD-specific antinuclear antibodies was found in 7%, but only rarely specific antibodies (anti-dsDNA 1.4%, anti-SS-A and -SS-B 0.2% each, anti-CENP-B 0.4%) were confirmed., Conclusions: In our study, a specific correlation between JIA and other autoimmune phenomena could not be confirmed. The lack of well-matched control groups makes interpretation challenging. Further data need to corroborate the suspected increased risk of developing other autoimmune phenomena in JIA patients., (© 2022. The Author(s).)
Published: 2022
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40. Culturomics Approaches Expand the Diagnostic Accuracy for Sexually Transmitted Infections.

Author: Wolf EA, Rettig HC, Lupatsii M, Schlüter B, Schäfer K, Friedrich D, Graspeuntner S, and Rupp J
Subjects: Female, Humans, Sexually Transmitted Diseases microbiology, Cell Culture Techniques methods, Microbiota, Sexually Transmitted Diseases diagnosis, Vagina microbiology
Abstract: Sexually transmitted infections (STIs) are a major health concern with clinical manifestations being acknowledged to cause severe reproductive impairment. Research in infectious diseases has been centered around the known major pathogens for decades. However, we have just begun to understand that the microbiota of the female genital tract is of particular importance for disease initiation, infection progression, and pathological outcome. Thus, we are now aware that many poorly described, partially not yet known, or cultured bacteria may pave the way for an infection and/or contribute to disease severity. While sequencing-based methods are an important step in diagnosing STIs, culture-based methods are still the gold-standard method in diagnostic routine, providing the opportunity to distinguish phenotypic traits of bacteria. However, current diagnostic culture routines suffer from several limitations reducing the content of information about vaginal microbiota. A detailed characterization of microbiota-associated factors is needed to assess the impact of single-bacterial isolates from the vaginal community on vaginal health and the containment of STIs. Here we provide current concepts to enable modern culture routines and create new ideas to improve diagnostic approaches with a conjunct usage of bioinformatics. We aim to enable scientists and physicians alike to overcome long-accepted limitations in culturing bacteria of interest to the human health. Eventually, this may improve the quality of culture-based diagnostics, facilitate a research interface, and lead to a broader understanding of the role of vaginal microbiota in reproductive health and STIs.
Published: 2021
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41. Studienstart International of the University of Cologne: The closely supervised semester of study entry for students from third countries using the example of the model degree program for human medicine.

Author: Karay Y, Restel K, Marek R, and Schlüter de Castro B
Subjects: Adolescent, Adult, Chi-Square Distribution, Education, Medical, Undergraduate statistics & numerical data, Educational Measurement methods, Educational Measurement statistics & numerical data, Female, Germany, Humans, Male, Models, Educational, Students, Medical statistics & numerical data, Universities organization & administration, Universities trends, Curriculum trends, Education, Medical, Undergraduate standards, Internationality
Abstract: Objective: Due to the increasing degree of internationalization and migration movements, German universities must increasingly pay attention to the cultural diversity of their students. Numerous studies have shown that there is still considerable room for improvement at German universities with regard to the integration of foreign students. Therefore, the University of Cologne aims at improving study conditions for students from third countries (especially non-EU) by introducing a compulsory study entry semester Studienstart International . In this study, we ask if effects on the dropout rates of international students before the introduction of Studienstart International can be observed after the introduction of the study entry semester. In addition, results of a survey of foreign students about familiarizing themselves with the German university educational system and on social contacts with fellow students are presented. Methods: After a one-year voluntary pilot phase in summer semester 2009 and winter semester 2009/10, Studienstart International was made compulsory for Non-EU students in preparation for the study of human medicine. 113 students of the human medicine degree program have taken part in this program since the beginning of winter semester 2016/17. The comparison of dropout rates before and after the introduction of Studienstart International as well as the results from a survey of foreign students are presented descriptively. Statistical significance of the difference in dropout rates between the two groups of students is tested using a Chi 2 -test. Results: The dropout rates of foreign students fell slightly from 19% to 14% following the introduction of the mandatory study entry semester, but this difference is not statistically significant (Chi 2 =0.785, df=1, p=0.376). According to the survey, almost three-quarters of foreign students have contact with German fellow students at the university, 55% of whom report daily contact. 68% of respondents have contact with German fellow students outside the university. 97% feel they are well prepared for the degree course and 91% say they know where to go with questions and problems during their studies. Conclusion: With the introduction of the compulsory study entry semester Studienstart International , the University of Cologne aims at improving integration of foreign students. Although dropout rates could not be significantly reduced, survey results suggest that Studienstart International can certainly support international students. Reliable statements on the success of the study cannot yet be made due to the small number of cases. A follow-up study will deal with this question.
Published: 2018
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42. Patterns of civilian and child deaths due to war-related violence in Syria: a comparative analysis from the Violation Documentation Center dataset, 2011-16.

Author: Guha-Sapir D, Schlüter B, Rodriguez-Llanes JM, Lillywhite L, and Hicks MH
Subjects: Adult, Child, Databases, Factual, Female, Humans, Male, Syria epidemiology, Child Mortality trends, Mortality trends, Violence statistics & numerical data, Warfare
Abstract: Background: Since March, 2011, the Syrian civil war has lowered life expectancy by as much as 20 years. We describe demographic, spatial, and temporal patterns of direct deaths of civilians and opposition combatants from conflict-related violence in 6 years of war., Methods: We analysed conflict-related violent deaths with complete information on date, place, and cause of death and demographic group occurring from March 18, 2011, to Dec 31, 2016, recorded by the Violation Documentation Center (VDC). We included civilian and combatant deaths in all Syrian governorates, excluding government-controlled areas. We did not include detainees and missing persons, nor deaths from siege conditions or insufficient medical care. We categorised deaths based on VDC weapon type. We used χ 2 testing to compare deaths from different weapons in civilian men, women, boys, and girls and adult and child combatants. We analysed deaths by governorate and over time., Findings: The VDC recorded 143 630 conflict-related violent deaths with complete information between March 18, 2011, and Dec 31, 2016. Syrian civilians constituted 101 453 (70·6%) of the deaths compared with 42 177 (29·4%) opposition combatants. Direct deaths were caused by wide-area weapons of shelling and air bombardments in 58 099 (57·3%) civilians, including 8285 (74·6%) civilian women and 13 810 (79·4%) civilian children, and in 4058 (9·6%) opposition combatants. Proportions of children among civilian deaths increased from 8·9% (388 of 4254 civilian deaths) in 2011 to 19·0% (4927 of 25 972) in 2013 and to 23·3% (2662 of 11 444) in 2016. Of 7566 deaths from barrel bombs, 7351 (97·2%) were civilians, of whom 2007 (27·3%) were children. Of 20 281 deaths by execution, 18 747 (92·4%) were civilians and 1534 (7·6%) were opposition combatants. Compared with opposition child soldiers who were male (n=333), deaths of civilian male children (n=11 730) were caused more often by air bombardments (39·2% vs 5·4%, p<0·0001) and shelling (37·3% vs 13·2%, p<0·0001) and less often by shooting (12·5% vs 76·0%, p<0·0001)., Interpretation: Aerial bombing and shelling rapidly became primary causes of direct deaths of women and children and had disproportionate lethal effects on civilians, calling into question the use of wide-area explosive weapons in urban areas. Increased reliance on aerial bombing by the Syrian Government and international partners is likely to have contributed to findings that children were killed in increasing proportions over time, ultimately comprising a quarter of civilian deaths in 2016. The inordinate proportion of civilians among the executed is consistent with deliberate tactics to terrorise civilians. Deaths from barrel bombs were overwhelmingly civilian rather than opposition combatants, suggesting indiscriminate or targeted warfare contrary to international humanitarian law and possibly constituting a war crime., Funding: None., (Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
Published: 2018
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43. Diagnostic Performance of an Anti-Actin Autoantibody Binding Enzyme Immunodot Blot in Autoimmune Hepatitis Type 1.

Author: Schotte H, Willeke P, Schmalhorst J, and Schlüter B
Subjects: Adolescent, Adult, Aged, Female, Fluorescent Antibody Technique, Indirect, Humans, Male, Middle Aged, Observer Variation, Reference Standards, Actins immunology, Autoantibodies metabolism, Enzyme-Linked Immunosorbent Assay methods, Hepatitis, Autoimmune diagnosis, Hepatitis, Autoimmune immunology
Abstract: Background: A serologic hallmark of autoimmune hepatitis (AIH) type 1 are anti-smooth muscle autoantibodies (ASMA) with specificity for filamentous actin (F-actin; AAA (anti-actin antibodies)), traditionally detected by indirect immunofluorescence (IFT) using rat liver, kidney, and stomach tissue sections as substrates. However, IFT is a subjective method requiring an experienced investigator. Therefore, a more objective technique for the detection of AAA may be a helpful diagnostic tool., Methods: In a retrospective study with cross-sectional design, we evaluated AAA detected by an enzyme immunodot blot (IDB; Liver5 IgG BlueDot, D-tek, Mons, Belgium). Serum samples of patients with AIH type 1 (n = 47) and specified controls (n = 142) were included. For comparison, standard IFT was applied to rat LKS (liver, kidney, stomach) triple tissue sections., Results: IDB readings were done by two independent investigators (92% concordance). The diagnostic sensitivity of the AAA-IDB was 70%, compared to 51% of AAA-IFT (n.s.). The diagnostic specificity of AAA-IDB was significantly lower compared to AAA-IFT (76% vs. 94%; P < 0.0005). Correspondingly, the positive predictive value (49% vs. 75%; P < 0.05) and positive likelihood ratio (2.9 vs. 8.5) differed significantly. Neither prescreening for ANA or ASMA, nor the exclusion of infectious hepatopathies resulted in a significantly better diagnostic performance of the IDB., Conclusion: Compared to standard IFT, testing for AAA via IDB did not result in a significantly better diagnostic performance for AIH type 1. A blot with higher antigen binding specificity may be more functional., (© 2014 Wiley Periodicals, Inc.)
Published: 2016
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44. Farm Exposure as a Differential Risk Factor in ANCA-Associated Vasculitis.

Author: Willeke P, Schlüter B, Sauerland C, Becker H, Reuter S, Jacobi A, and Schotte H
Subjects: Adult, Aged, Animals, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis blood, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis diagnosis, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis immunology, Antibodies, Antineutrophil Cytoplasmic blood, Arthritis, Rheumatoid blood, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid immunology, Case-Control Studies, Cattle, Churg-Strauss Syndrome blood, Churg-Strauss Syndrome diagnosis, Churg-Strauss Syndrome immunology, Female, Granulomatosis with Polyangiitis blood, Granulomatosis with Polyangiitis diagnosis, Granulomatosis with Polyangiitis immunology, Humans, Male, Microscopic Polyangiitis blood, Microscopic Polyangiitis diagnosis, Microscopic Polyangiitis immunology, Middle Aged, Odds Ratio, Risk Factors, Surveys and Questionnaires, Swine, Animal Husbandry, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis etiology, Churg-Strauss Syndrome etiology, Granulomatosis with Polyangiitis etiology, Occupational Exposure adverse effects
Abstract: Objective: To investigate the association of farm exposure and the development of ANCA-associated vasculitis (AAV)., Methods: One hundred eighty-nine well defined patients with AAV (n = 119 with granulomatosis with polyangiitis [GPA], n = 48 with microscopic polyangiitis [MPA], n = 22 patients with eosinophilic granulomatosis with polyangiitis [EGPA]) and 190 controls (n = 119 patients with rheumatoid arthritis, n = 71 with large vessel vasculitis) were interrogated using a structured questionnaire. Factors investigated were occupation, farm exposure, contact to different livestock, participation in harvesting, residence next to a farm, MRSA status, and contact to domestic pets at disease onset or ever before. The odds ratio (OR) and 95% confidence interval [95%CI] were calculated for each item., Results: Univariate analysis revealed a strong association of AAV with regular farm exposure; OR 3.44 [95%CI 1.43-8.27]. AAV was also associated with regular contact to cattle 4.30 (1.43-8.27), pigs 2.75 (1.12-6.75) and MRSA carriage 3.38 (1.11-10.3). This association was stronger in the subgroup of GPA patients. OR in this group for farm exposure was 4.97; [2.02-12.2], for cattle 6.71 [95% CI 2.19-20.7], for pigs 4.34 [1.75-10.9], and MRSA carriage 5.06 [1.62-15.8]). There was no significant association of MPA or EGPA with these parameters., Conclusion: A significant association between farm exposure or farm animal exposure and AAV especially in the subgroup of patients with GPA has been identified. This suggests that these entities are distinct and have different triggers for the immune process.
Published: 2015
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45. Putative IL-10 Low Producer Genotypes Are Associated with a Favourable Etanercept Response in Patients with Rheumatoid Arthritis.

Author: Schotte H, Schlüter B, Schmidt H, Gaubitz M, Drynda S, Kekow J, and Willeke P
Subjects: Adult, Aged, Aged, 80 and over, Alleles, Antirheumatic Agents pharmacology, Arthritis, Rheumatoid genetics, Etanercept pharmacology, Female, Gene Frequency, Genotype, Haplotypes genetics, Humans, Interleukin-10 biosynthesis, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide, Prednisolone therapeutic use, Promoter Regions, Genetic genetics, Young Adult, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Etanercept therapeutic use, Interleukin-10 genetics
Abstract: Outcome predictors of biologic therapeutic drugs like TNF inhibitors are of interest since side effects like serious infections or malignancy cannot be completely ruled out. Response rates are heterogeneous. The present study addressed the question whether in patients with rheumatoid arthritis (RA) interleukin-10 (IL-10) promoter genotypes with potential relevance for IL-10 production capacity are associated with response to long-term treatment with etanercept. Caucasian RA patients that, according to the EULAR criteria, responded well (n = 25), moderately (n = 17) or not (n = 8) to etanercept therapy (median 36 months, range 4-52), and 160 matched controls were genotyped for the IL-10 promoter SNPs -2849 G>A (rs6703630), -1082 G>A (rs1800896), -819 C>T (rs1800871) and -592 C>A (rs1800872). Haplotypes were reconstructed via mathematic model and tested for associations with disease susceptibility and therapy response. We identified the four predominant haplotypes AGCC, GATA, GGCC, and GACC in almost equal distribution. Patients that responded well carried the putative IL-10 low producer allele -2849 A or the haplotypes AGCC and GATA (RR 2.1 and 4.0, respectively; 95% CI 1.1-4.0 and 1.1-14.8), whereas an unfavourable response was associated with carriage of the putative high producer haplotype GGCC (RR 1.9, 95% CI 1.1-3.3). No significant associations of alleles or haplotypes with disease susceptibility were observed. In RA, a low IL-10 production which is genetically determined rather by haplotypes than by SNPs may favour the response to etanercept treatment. Iatrogenic blockade of TNF may reveal proinflammatory effects of its endogeneous antagonist IL-10. Further studies are needed to correlate these genetic findings to direct cytokine measurements.
Published: 2015
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46. Differential effects of cyclophosphamide and mycophenolate mofetil on cellular and serological parameters in patients with systemic lupus erythematosus.

Author: Fassbinder T, Saunders U, Mickholz E, Jung E, Becker H, Schlüter B, and Jacobi AM
Subjects: Adult, Cells, Cultured, Cross-Sectional Studies, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Lupus Erythematosus, Systemic diagnosis, Male, Middle Aged, Multivariate Analysis, Mycophenolic Acid administration & dosage, Plasma Cells cytology, Reference Values, Risk Assessment, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome, Cyclophosphamide administration & dosage, Immunosuppressive Agents administration & dosage, Lupus Erythematosus, Systemic drug therapy, Mycophenolic Acid analogs & derivatives, Plasma Cells drug effects
Abstract: Introduction: Disease activity and therapy show an impact on cellular and serological parameters in patients with systemic lupus erythematosus (SLE). This study was performed to compare the influence of mycophenolate mofetil (MMF) and cyclophosphamide (CYC) therapy on these parameters in patients with flaring, organ-threatening disease., Methods: SLE patients currently receiving CYC (n = 20), MMF (n = 25) or no immunosuppressive drugs (n = 22) were compared using a cross-sectional design. Median disease activity and daily corticosteroid dose were similar in these treatment groups. Concurrent medication, organ manifestations, and disease activity were recorded, and cellular and serological parameters were determined by routine diagnostic tests or flow cytometric analysis. In addition follow-up data were obtained from different sets of patients (CYC n = 24; MMF n = 23)., Results: Although both drugs showed a significant effect on disease activity and circulating B cell subsets, only MMF reduced circulating plasmablasts and plasma cells as well as circulating free light chains within three months of induction therapy. Neither MMF nor CYC were able to reduce circulating memory B cells. MMF lowered IgA levels more markedly than CYC. We did not observe a significant difference in the reduction of IgG levels or anti-dsDNA antibodies comparing patients receiving MMF or CYC. In contrast to MMF, induction therapy with CYC was associated with a significant increase of circulating CD8+ effector T cells and plasmacytoid dendritic cells (PDCs) after three months., Conclusions: The results indicate differences between MMF and CYC with regard to the mechanism of action. MMF, but not CYC, treatment leads to a fast and enduring reduction of surrogate markers of B cell activation, such as circulating plasmablasts, plasma cells and free light chains but a comparable rate of hypogammaglobulinemia.
Published: 2015
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47. Diagnostics and management of sleep-related respiratory disturbances in children with skeletal dysplasia caused by FGFR3 mutations (achondroplasia and hypochondroplasia).

Author: Schlüter B, De Sousa G, Trowitzsch E, and Andler W
Subjects: Achondroplasia genetics, Adenoidectomy, Adolescent, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Polysomnography methods, Receptor, Fibroblast Growth Factor, Type 3 genetics, Sleep Disorders, Intrinsic etiology, Snoring diagnosis, Snoring etiology, Snoring therapy, Tonsillectomy, Achondroplasia complications, Sleep Disorders, Intrinsic diagnosis, Sleep Disorders, Intrinsic therapy
Abstract: To evaluate the frequency of clinical indicators for sleep-related respiratory disturbances (SRD) and the polysomnographical manifestations of these disorders in children with skeletal dysplasia caused by FGFR3 mutations. From January 1990 to January 2009, 24 patients (22 achondroplasia, 2 hypochondroplasia; 13 boys, 11 girls; age 8 days to 15 years, median age 3.0 years) were examined, including a semi-structured interview, a clinical examination, and a polysomnographic sleep recording (65 polysomnographic sleep recordings (PSG) in 24 patients). We performed PSG in a subgroup of five patients before and after adenoidectomy (AT) and/or tonsilectomy (TE). Daytime symptoms suggestive of SRD (daytime somnolence, attention and concentration problems, behavioural problems, and pallor) were found in 4/24 patients (16.7%). Sleep-related symptoms (snoring, mouth breathing, cyanosis, observed apneas, excessive sweating, enuresis, problems of initiating and maintaining sleep) were present in 18/24 patients (75%). Prior to the first PSG, 11/24 patients (45.8%) had undergone AT, 1/24 (4.2%) TE, 2/24 (8.3%) adenotonsilectomy (ATE), 3/24 (12.5%) liquor drainage, and 6/24 (25%) a craniocervical decompression operation. Clinical examination prior to PSG revealed hypertrophied tonsils in 11/24 patients (45.8%), disturbed nasal breathing in 8/24 patients (33.3), and enlarged cervical lymph nodes as a sign of chronic tonsillitis in 5/24 patients (20.8%). PSG findings were abnormal in 19/24 patients (79.2%) with a nadir of oxygen saturation (pulse oximetry) below 90% and/or a nadir of transcutaneous partial pressure of oxygen below 45 mmHg. Pathologic PSG findings were found in 10/24 patients (41.7%): obstructive sleep apnea syndrome (OSAS) was diagnosed in 8/24 patients (33.3%), central sleep apnea syndrome in 1/24 patients (4.2%), and hypoventilation in 1/24 patients (4.2%). As a consequence, the following therapeutic interventions were performed: AT in 1/24 patients (4.2%), TE in 2/24 (8.3%), ATE in 2/24 (8.3%), and nasal continuous positive airway pressure (continuous positive airway pressure) and bilevel positive airway pressure therapy (bilevel positive airway pressure), respectively, in 3/24 patients(12.5%). SRD, especially OSAS, represent a complication of clinical and prognostic relevance in children with achondroplasia. We therefore think that not only those children with a history suggestive of SRD, but all achondroplastic children should be evaluated by PSG. At least in a part of these patients, the pathophysiological mechanisms of OSAS are connected with the etiology of achondroplasia. Achondroplastic children with OSAS, who do not benefit from AT and/or TE, should be treated with NCPAP therapy.
Published: 2011

48. [Sleep problems in childhood: basis of sleep regulation and intervention possibilities].

Author: Schlüter B
Subjects: Child, Humans, Sleep Wake Disorders epidemiology, Sleep Wake Disorders therapy
Abstract: In the article there is provided the up-to-date information about fundamentals of sleep regulation in childhood, sleep disturbances and treatment possibilities as well.
Published: 2008

49. Clinical and immunological characteristics of patients with Sjögren's syndrome in relation to alpha-fodrin antibodies.

Author: Willeke P, Gaubitz M, Schotte H, Becker H, Mickholz E, Domschke W, and Schlüter B
Subjects: Adult, Aged, Biomarkers blood, Cytokines biosynthesis, Enzyme-Linked Immunosorbent Assay, Female, HLA-DR Antigens genetics, Humans, Immunoglobulin A blood, Immunoglobulin G blood, Leukocytes, Mononuclear immunology, Lymphocyte Activation immunology, Male, Middle Aged, Monocytes immunology, T-Lymphocyte Subsets immunology, Autoantibodies blood, Carrier Proteins immunology, Microfilament Proteins immunology, Sjogren's Syndrome immunology
Abstract: Objectives: To analyse the prevalence of alpha-fodrin antibodies in patients with primary (pSS) and secondary Sjögren's syndrome (sSS) and the relation to clinical, serological and immunological features., Methods: Serum IgA and IgG antibodies to the 120 kDa alpha-fodrin were determined by ELISA technique in 62 pSS patients and 28 sSS patients. Results were correlated with clinical symptoms and laboratory findings as well as with the HLA-DR genotype. Additionally, antibody concentrations were correlated with the numbers of peripheral blood mononuclear cells (PBMCs) secreting interleukin (IL)-6, IL-10, interferon-gamma (INF)-gamma, and tumour necrosis factor-alpha determined by ELISPOT analysis. Lymphocytes and monocytes were examined flow-cytometrically for the expression of activation markers. Healthy age- and sex-matched volunteers served as controls., Results: The sensitivity of IgA and IgG alpha-fodrin antibodies was 35 and 31%, respectively, in pSS patients. In sSS patients, the sensitivity was 29 and 21%, respectively. In pSS patients with IgG antibodies, recurrent parotid swelling was significantly more prevalent. Also the number of INF-gamma secreting PBMCs and the percentage of CD4/CD71+ lymphocytes as well as CD14/HLA-DR+ monocytes were significantly increased in this group compared with alpha-fodrin-negative patients or with controls. Interestingly, these patients also had a shorter disease duration. No association of alpha-fodrin antibodies with the HLA-DR genotype was found., Conclusion: Due to the low prevalence, serum antibodies to alpha-fodrin turned out to be of limited diagnostic value in our study. However, our data suggest that IgG antibodies to alpha-fodrin are indicative of clinical and immunological activity in pSS especially in patients with shorter disease duration and may thus serve as a marker of disease activity.
Published: 2007
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50. Increased serum levels of macrophage migration inhibitory factor in patients with primary Sjögren's syndrome.

Author: Willeke P, Gaubitz M, Schotte H, Maaser C, Domschke W, Schlüter B, and Becker H
Subjects: Cytokines blood, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, HLA-DR Antigens genetics, Humans, Interleukin-10 blood, Lymphocyte Activation immunology, Lymphocytes immunology, Lymphocytes metabolism, Male, Middle Aged, Sjogren's Syndrome genetics, Sjogren's Syndrome physiopathology, Macrophage Migration-Inhibitory Factors blood, Sjogren's Syndrome blood
Abstract: The objective of this study was to analyse levels of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) in patients with primary Sjögren's syndrome (pSS) and to examine associations of MIF with clinical, serological and immunological variables. MIF was determined by ELISA in the sera of 76 patients with pSS. Further relevant cytokines (IL-1, IL-6, IL-10, IFN-gamma and TNF-alpha) secreted by peripheral blood mononuclear cells (PBMC) were determined by ELISPOT assay. Lymphocytes and monocytes were examined flow-cytometrically for the expression of activation markers. Results were correlated with clinical and laboratory findings as well as with the HLA-DR genotype. Healthy age- and sex-matched volunteers served as controls. We found that MIF was increased in patients with pSS compared with healthy controls (p < 0.01). In particular, increased levels of MIF were associated with hypergammaglobulinemia. Further, we found a negative correlation of MIF levels with the number of IL-10-secreting PBMC in pSS patients (r = -0.389, p < 0.01). Our data indicate that MIF might participate in the pathogenesis of primary Sjögren's syndrome. MIF may contribute to B-cell hyperactivity indicated by hypergammaglobulinemia. The inverse relationship of IL-10 and MIF suggests that IL-10 works as an antagonist of MIF in pSS.
Published: 2007
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