1. Familial Acute Promyelocytic Leukemia: A Case Report and Review of the Literature
- Author
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Yang M, Bai L, Ma Y, Cao X, Cui Q, Wu D, and Tang X
- Subjects
familial ,acute promyelocytic leukemia ,apl differentiation syndrome ,hereditary predisposition ,germline mutation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Mingqi Yang,1,2 Lian Bai,3 Yunju Ma,1,2 Xuanqi Cao,1,2 Qingya Cui,1,2 Depei Wu,1,2 Xiaowen Tang1,2 1National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People’s Republic of China; 3Canglang Hospital of Suzhou, Suzhou, People’s Republic of ChinaCorrespondence: Xiaowen Tang; Depei Wu, Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, People’s Republic of China, Tel +8613913538266 ; +8613951102021, Email xwtang1020@163.com; drwudepei@163.comAbstract: Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation t (15;17) (q24;q21), which leads to the fusion of PML and RARα genes known as PML-RARα fusion. A few cases of potentially hereditary leukemia-related genes in APL have been reported, but no instances of familial aggregation of APL have been documented. Here, we describe a family in whom two members successively affected by APL。The potential familial association observed in these two cases of APL highlights the need for further investigation and more definitive genetic lineage tracing in order to understand the genetic basis of this disease.Keywords: familial, acute promyelocytic leukemia, APL differentiation syndrome, hereditary predisposition, germline mutation
- Published
- 2024