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2. Factors Associated with Site-specific Distribution of Glioblastoma

Author

LI Wenting, BAO Hongbo, and LIANG Peng

Subjects
glioma, anatomy, spatial distribution, molecular feature, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

The treatment of glioblastoma, the most prevalent malignant tumor in the central nervous system, poses considerable challenges. Glioblastoma multiforme, classified as a grade Ⅳ highly malignant brain glioma by the World Health Organization, is typically managed through a combination of surgery, postoperative chemotherapy, and radiotherapy. The treatment of glioblastoma is complicated by its infiltrative nature, genetic heterogeneity, and presence of the blood-brain barrier. Almost all cases of glioblastoma experience recurrence despite aggressive therapy, exploring the development of updated molecular treatment strategies that can improve overall efficacy. A crucial aspect in modern neurosurgery is the precise delineation of brain regions in terms of their anatomy and function. It serves as the fundamental basis for investigating variations in the distribution of brain gliomas. Hence, this review will elucidate the origin of glioblastomas and analyze the potential factors contributing to the spatially specific distribution of gliomas on the basis of a theoretical framework of brain connectomics research. Molecular characteristics, information pathways, tumor microenvironment landscape, and immunology will inform the analysis. We aim to identify novel biomolecular targets and therapeutic pathways to gain scientific insights for effective glioblastoma treatment.

Published
2024
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11. Additional file 1 of Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration

Author

Ding, Wencai, Ren, Peng, Yi, Liye, Si, Yao, Yang, Fan, Li, Zhipeng, Bao, Hongbo, Yan, Shi, Zhang, Xinyu, Li, Siyang, Liang, Xia, and Yao, Lifen

Abstract

Additional file 1: Supplementary Table 1. Structural T1 and diffusion weighted image acquisition protocols.

Published
2023
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12. Corrigendum: Developing an immune-related signature for predicting survival rate and the response to immune checkpoint inhibitors in patients with glioma

Author

Zhang, Sibin, primary, Xiao, Xu, additional, Wang, Yu, additional, Song, Tianjun, additional, Li, Chenlong, additional, Bao, Hongbo, additional, Liu, Qing, additional, Sun, Guiyin, additional, Sun, Xiaoyang, additional, Su, Tianqi, additional, Fu, Tianjiao, additional, Wang, Yujie, additional, and Liang, Peng, additional

Published
2022
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13. Developing an Immune-Related Signature for Predicting Survival Rate and the Response to Immune Checkpoint Inhibitors in Patients With Glioma

Author

Zhang, Sibin, primary, Xiao, Xu, additional, Wang, Yu, additional, Song, Tianjun, additional, Li, Chenlong, additional, Bao, Hongbo, additional, Liu, Qing, additional, Sun, Guiyin, additional, Sun, Xiaoyang, additional, Su, Tianqi, additional, Fu, Tianjiao, additional, Wang, Yujie, additional, and Liang, Peng, additional

Published
2022
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19. Cyclophilin A Maintains Glioma-Initiating Cell Stemness by Regulating Wnt/β-Catenin Signaling

Author

Wang, Guangzhi, primary, Shen, Jia, additional, Sun, Jiahang, additional, Jiang, Zhenfeng, additional, Fan, Jiabing, additional, Wang, Hongjun, additional, Yu, Shan, additional, Long, Yu, additional, Liu, Yi, additional, Bao, Hongbo, additional, Zhang, Kelvin Xi, additional, Han, Ke, additional, Zhu, Minwei, additional, Zheng, Yongri, additional, Lin, Zhiguo, additional, Jiang, Chuanlu, additional, and Guo, Mian, additional

Published
2017
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20. miRNA-214 Inhibits Cellular Proliferation and Migration in Glioma Cells Targeting Caspase 1 Involved in Pyroptosis

Author

Jiang, Zhenfeng, primary, Yao, Lifen, additional, Ma, Hongge, additional, Xu, Panpan, additional, Li, Zhiyan, additional, Guo, Mian, additional, Chen, Jianhang, additional, Bao, Hongbo, additional, Qiao, Shupei, additional, Zhao, Yufang, additional, Shen, Jia, additional, Zhu, Minwei, additional, Meyers, Carolyn, additional, Ma, Guizhen, additional, Xie, Chuncheng, additional, Liu, Li, additional, Wang, Haiyang, additional, Zhang, Wang, additional, Dong, Qi, additional, Shen, Hong, additional, and Lin, Zhiguo, additional

Published
2017
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21. CD70, a novel target of CAR T-cell therapy for gliomas

Author

Jin, Linchun, primary, Ge, Haitao, additional, Long, Yu, additional, Yang, Changlin, additional, Chang, Yifan (Emily), additional, Mu, Luyan, additional, Sayour, Elias J, additional, De Leon, Gabriel, additional, Wang, Qiong J, additional, Yang, James C, additional, Kubilis, Paul S, additional, Bao, Hongbo, additional, Xia, Songsong, additional, Lu, Dunyue, additional, Kong, Yingjun, additional, Hu, Li, additional, Shang, Yujiao, additional, Jiang, Chencheng, additional, Nie, Jing, additional, Li, Shimin, additional, Gu, Yunhe, additional, Sun, Jiahang, additional, Mitchell, Duane A, additional, Lin, Zhiguo, additional, and Huang, Jianping, additional

Published
2017
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23. IMST-25. CD70—A NOVEL TARGET OF CAR-T-CELL THERAPY FOR GLIOMAS

Author

Jin, Linchun, primary, Ge, Haitao, additional, Yang, Changlin, additional, Long, Yu, additional, Chang, Yifan, additional, Mu, Luyan, additional, Sayour, Elias, additional, Leon, Gabriel De, additional, Wang, Qiong, additional, Yang, James, additional, Drake, Jeffrey, additional, Kubilis, Paul, additional, Bao, Hongbo, additional, Xia, Songsong, additional, Lu, Dunyue, additional, Kong, Yingjun, additional, Hu, Li, additional, Yin, Yibo, additional, Shang, Yujiao, additional, Jiang, Chencheng, additional, Nie, Jing, additional, Li, Shimin, additional, Qi, Jiping, additional, Gu, Yunhe, additional, Sun, Jiahang, additional, Lin, Zhiguo, additional, Mitchell, Duane, additional, and Huang, Jianping, additional

Published
2016
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24. IMST-27. CD70–A CRITICAL MEDIATOR OF TUMOR PROGRESSION AND IMMUNOSUPPRESSION IN GLIOMAS

Author

Ge, Haitao, primary, Jin, Linchun, additional, Yang, Changlin, additional, Long, Yu, additional, Chang, Yifan, additional, Mu, Luyan, additional, Sayour, Elias, additional, DeLeon, Gabriel, additional, Drake, Jeffrey, additional, Kubilis, Paul, additional, Bao, Hongbo, additional, Xia, Songsong, additional, Lu, Dunyue, additional, Kong, Yingjun, additional, Hu, Li, additional, Yin, Yibo, additional, Shang, Yujiao, additional, Jiang, Chencheng, additional, Nie, Jing, additional, Li, Shimin, additional, Qi, Jiping, additional, Gu, Yunhe, additional, Sun, Jiahang, additional, Lin, Zhiguo, additional, Mitchell, Duane, additional, and Huang, Jianping, additional

Published
2016
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26. IMST-23. TUMOR IMMUNOSUPPRESSION IS TIGHTLY COUPLED WITH IDH WILD-TYPE IN GLIOMA PATIENTS

Author

Mu, Luyan, primary, Yang, Changlin, additional, Gu, Yunhe, additional, Ge, Haitao, additional, (Emily) Chang, Yifan, additional, Leon, Gabriel De, additional, Sayour, Elias, additional, Xia, Songsong, additional, Bao, Hongbo, additional, Yu, Long, additional, Jin, Linchun, additional, Qi, Jiping, additional, Sun, Jiahang, additional, Gao, Xiang, additional, Song, Ying Ching, additional, Kubilis, Paul, additional, Mitchell, Duane, additional, Lin, Zhiguo, additional, and Huang, Jianping, additional

Published
2016
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27. IMPS-42CD70—A KEY DRIVER OF CHEMOKINE-MEDIATED IMMUNE SUPPRESSION AND INDICATOR OF NEGATIVE PROGNOSIS FOR GLIOBLASTOMA

Author

Ge, Haitao, primary, Yang, Changlin, additional, Jin, Linchun, additional, Xia, Songsong, additional, Bao, Hongbo, additional, Long, Yu, additional, Mu, Luyan, additional, Yin, Yibo, additional, Qi, Jiping, additional, Chang, Yifan, additional, Drake, Jeffrey, additional, De Leon, Gabriel, additional, Friedman, William A., additional, Mitchell, Duane A., additional, Lin, Zhiguo, additional, and Huang, Jianping, additional

Published
2015
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28. CD70, a novel target of CAR T-cell therapy for gliomas.

Author

Jin L, Ge H, Long Y, Yang C, Chang YE, Mu L, Sayour EJ, De Leon G, Wang QJ, Yang JC, Kubilis PS, Bao H, Xia S, Lu D, Kong Y, Hu L, Shang Y, Jiang C, Nie J, Li S, Gu Y, Sun J, Mitchell DA, Lin Z, and Huang J

Subjects
Animals, Brain Neoplasms immunology, Brain Neoplasms pathology, Cell Line, Tumor, Glioma, Humans, Immunotherapy, Adoptive methods, Isocitrate Dehydrogenase genetics, Mice, T-Lymphocytes immunology, Tumor Microenvironment immunology, Brain Neoplasms therapy, CD27 Ligand immunology, Receptors, Chimeric Antigen immunology
Abstract

Background: Cancer immunotherapy represents a promising treatment approach for malignant gliomas but is hampered by the limited number of ubiquitously expressed tumor antigens and the profoundly immunosuppressive tumor microenvironment. We identified cluster of differentiation (CD)70 as a novel immunosuppressive ligand and glioma target., Methods: Normal tissues derived from 52 different organs and primary and recurrent low-grade gliomas (LGGs) and glioblastomas (GBMs) were thoroughly evaluated for CD70 gene and protein expression. The association between CD70 and patients' overall survival and its impact on T-cell death was also evaluated. Human and mouse CD70-specific chimeric antigen receptors (CARs) were tested respectively against human primary GBMs and murine glioma lines. The antitumor efficacies of these CARs were also examined in orthotopic xenograft and syngeneic models., Results: CD70 was not detected in peripheral and brain normal tissues but was constitutively overexpressed by isocitrate dehydrogenase (IDH) wild-type primary LGGs and GBMs in the mesenchymal subgroup and recurrent tumors. CD70 was also associated with poor survival in these subgroups, which may link to its direct involvement in glioma chemokine productions and selective induction of CD8+ T-cell death. To explore the potential for therapeutic targeting of this newly identified immunosuppressive axis in GBM tumors, we demonstrate that both human and mouse CD70-specific CAR T cells recognize primary CD70+ GBM tumors in vitro and mediate the regression of established GBM in xenograft and syngeneic models without illicit effect., Conclusion: These studies identify a previously uncharacterized and ubiquitously expressed immunosuppressive ligand CD70 in GBMs that also holds potential for serving as a novel CAR target for cancer immunotherapy in gliomas., (© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com)

Published
2018
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