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6. Crosstalk Between NK Cell Receptors and Tumor Membrane Hsp70‐Derived Peptide: A Combined Computational and Experimental Study

Author

Yazdi, Mina, primary, Hasanzadeh Kafshgari, Morteza, additional, Khademi Moghadam, Fatemeh, additional, Zarezade, Vahid, additional, Oellinger, Rupert, additional, Khosravi, Mohammad, additional, Haas, Stefan, additional, Hoch, Cosima C., additional, Pockley, Alan Graham, additional, Wagner, Ernst, additional, Wollenberg, Barbara, additional, Multhoff, Gabriele, additional, and Bashiri Dezfouli, Ali, additional

Published
2024
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7. Biomarkers in Adult-Type Diffuse Gliomas: Elevated Levels of Circulating Vesicular Heat Shock Protein 70 Serve as a Biomarker in Grade 4 Glioblastoma and Increase NK Cell Frequencies in Grade 3 Glioma

Author

Lennartz, Philipp, primary, Thölke, Dennis, additional, Bashiri Dezfouli, Ali, additional, Pilz, Mathias, additional, Lobinger, Dominik, additional, Messner, Verena, additional, Zanth, Hannah, additional, Ainslie, Karen, additional, Kafshgari, Morteza Hasanzadeh, additional, Rammes, Gerhard, additional, Ballmann, Markus, additional, Schlegel, Martin, additional, Foulds, Gemma Ann, additional, Pockley, Alan Graham, additional, Schmidt-Graf, Friederike, additional, and Multhoff, Gabriele, additional

Published
2023
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9. Elevated circulating Hsp70 levels are correlative for malignancies in different mammalian species

Author

Salvermoser, Lukas, Flisikowski, Krzysztof, Dressel-Böhm, Susann, Nytko, Katarzyna J, Rohrer Bley, Carla, Schnieke, Angelika, Samt, Ann-Kathrin, Thölke, Dennis, Lennartz, Philipp, Schwab, Melissa, Wang, Fei, Bashiri Dezfouli, Ali, Multhoff, Gabriele, University of Zurich, and Salvermoser, Lukas

Subjects
1307 Cell Biology, 10253 Department of Small Animals, 1303 Biochemistry, 630 Agriculture, 570 Life sciences, biology, Cell Biology, Biochemistry
Abstract

Circulating Hsp70 levels were determined in feline and porcine cohorts using two different ELISA systems. These comparative animal models of larger organisms often reflect diseases, and especially malignant tumors, better than conventional rodent models. It is therefore essential to investigate the biology and utility of tumor biomarkers in animals such as cats and pigs. In this study, levels of free Hsp70 in the blood of cats with spontaneously occurring tumors were detected using a commercial Hsp70 ELISA (R&D Systems). Sub-analysis of different tumor groups revealed that animals with tumors of epithelial origin presented with significantly elevated circulating Hsp70 concentrations. In addition to free Hsp70 levels measured with the R&D Systems Hsp70 ELISA, levels of exosomal Hsp70 were determined using the compHsp70 ELISA in pigs. Both ELISA systems detected significantly elevated Hsp70 levels (R&D Systems: median 24.9 ng/mL; compHsp70: median 44.2 ng/mL) in the blood of a cohort of APC1311/+ pigs diagnosed with high-grade adenoma polyps, and the R&D Systems Hsp70 ELISA detected also elevated Hsp70 levels in animals with low-grade polyps. In contrast, in flTP53R167H pigs, suffering from malignant osteosarcoma, the compHsp70 ELISA (median 674.32 ng/mL), but not the R&D Systems Hsp70 ELISA (median 4.78 ng/mL), determined significantly elevated Hsp70 concentrations, indicating that in tumor-bearing animals, the dominant form of Hsp70 is of exosomal origin. Our data suggest that both ELISA systems are suitable for detecting free circulating Hsp70 levels in pigs with high-grade adenoma, but only the compHsp70 ELISA can measure elevated, tumor-derived exosomal Hsp70 levels in tumor-bearing animals.

Published
2022

12. CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells

Author

Bashiri Dezfouli, Ali, primary, Yazdi, Mina, additional, Benmebarek, Mohamed-Reda, additional, Schwab, Melissa, additional, Michaelides, Stefanos, additional, Miccichè, Arianna, additional, Geerts, Dirk, additional, Stangl, Stefan, additional, Klapproth, Sarah, additional, Wagner, Ernst, additional, Kobold, Sebastian, additional, and Multhoff, Gabriele, additional

Published
2022
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14. Evaluating Total Mercury and Methyl Mercury Contents in Canned Tuna Fish of the Persian Gulf

Author

Bashiri Dezfouli, Ali, Salar-Amoli, Jamileh, Ali-Esfahani, Tahereh, Hosseini, Hedayat, and Ghanati, Kiandokht

Subjects
Persian Gulf, Food hygiene, food and beverages, Original Article, Mercury, Methyl mercury, human activities, humanities, Canned tuna
Abstract

Due to hygienic risks of mercury residues in food and marine originated supplements, measuring total mercury and methyl mercury contents of canned tuna as a highly consumable marine food product is essential. In this study, 40 canned Tuna fish (from Persian Gulf) were collected in 2015 and then flame atomic absorption spectrometer (FAAS) and thermo gas chromatography mass spectrophotometry were used to measure total mercury and methyl mercury, respectively. The results indicated that the average contents of total mercury and methyl mercury of the canned tunas, with 34.2 and 29.5 ppb decrements compared with 2009's measurement, were 177.4 and 143.7 ppb respectively. The highest concentration of the total mercury was 315.2 while it was 267.9 ppb for methyl mercury. This study showed that the content of the mercury in canned tunas of the Persian Gulf was less than the Maximum Residue Limit (MRL).

Published
2018

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