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1. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.

Author

Schijven, Dick, Postema, Merel C, Fukunaga, Masaki, Matsumoto, Junya, Miura, Kenichiro, de Zwarte, Sonja MC, van Haren, Neeltje EM, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa, Ortiz-García de la Foz, Víctor, Tordesillas-Gutierrez, Diana, Vázquez-Bourgon, Javier, Crespo-Facorro, Benedicto, Alnæs, Dag, Dahl, Andreas, Westlye, Lars T, Agartz, Ingrid, Andreassen, Ole A, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E, Schall, Ulrich, Scott, Rodney J, Carr, Vaughan J, Green, Melissa J, Henskens, Frans A, Loughland, Carmel M, Pantelis, Christos, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo TJ, Nenadić, Igor, Krämer, Bernd, Gruber, Oliver, Satterthwaite, Theodore D, Bustillo, Juan, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D, Ford, Judith M, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan, Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond, Sarró, Salvador, Pomarol-Clotet, Edith, Ciullo, Valentina, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N, Sim, Kang, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André, Borgwardt, Stefan, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, and Antonucci, Linda A

Subjects
Brain, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Case-Control Studies, Schizophrenia, Female, Male, Functional Laterality, asymmetry, brain imaging, cortical, subcortical, Clinical Research, Mental Health, Neurosciences, Brain Disorders, Mental health
Abstract

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

Published
2023

2. Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Author

Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A, Arango, Celso, Arolt, Volker, Auzias, Guillaume, Ayesa-Arriola, Rosa, Banaj, Nerisa, Banaschewski, Tobias, Bandeira, Cibele, Başgöze, Zeynep, Cupertino, Renata Basso, Bau, Claiton HD, Bauer, Jochen, Baumeister, Sarah, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Brem, Silvia, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R, Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carmona, Susanna, Carr, Vaughan J, Catts, Stanley V, Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G, Conzelmann, Annette, Craven, Alexander R, Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Dannlowski, Udo, Davey, Christopher G, Deruelle, Christine, Díaz-Caneja, Covadonga M, Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T, Fedor, Jennifer, Fitzgerald, Jacqueline, Foran, William, Ford, Judith M, Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Gao, Bingchen, Gao, Si, Goikolea, Jose M, Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J, Green, Melissa, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Haavik, Jan, Hahn, Tim, Harrison, Ben J, Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J, Hilland, Eva, Hoekstra, Pieter J, Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M, Ipser, Jonathan C, Jahanshad, Neda, Jakobi, Babette, Jansen, Andreas, Janssen, Joost, Jonassen, Rune, Kaiser, Anna, Kaleda, Vasiliy, Karantonis, James, King, Joseph A, Kircher, Tilo, Kochunov, Peter, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, and Lawrie, Stephen

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Neurosciences, Genetics, Mental Health, Serious Mental Illness, Mental Illness, Women's Health, Brain Disorders, Preterm, Low Birth Weight and Health of the Newborn, Pregnancy, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Behavioral and Social Science, Prevention, Schizophrenia, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Neurological, Reproductive health and childbirth, Mental health, Good Health and Well Being, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Bipolar Disorder, Cerebral Cortex, Child, Depressive Disorder, Major, Female, Humans, Infant, Newborn, Magnetic Resonance Imaging, Premature Birth, Cortical growth, Cortical surface area, Mental illness, Neurodevelopment, Neurogenesis, Psychiatric disorders, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences
Abstract

BackgroundMorphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life.MethodsInterregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed.ResultsAcross the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth.ConclusionsOur findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

Published
2022

3. Extraction of bare Form Factors for $\mathrm B_\mathrm s \to \mathrm K \ell \nu$ Decays in non-perturbative HQET

Author

Bahr, Felix, Banerjee, Debasish, Bernardoni, Fabio, Koren, Mateusz, Simma, Hubert, and Sommer, Rainer

Subjects
High Energy Physics - Lattice
Abstract

We discuss the extraction of the ground state $\langle \mathrm{K} ({\bf p})|V_\mu(0)|\mathrm{B} ({\bf 0})\rangle$ matrix elements from Euclidean lattice correlation functions. The emphasis is on the elimination of excited state contributions. Two typical gauge-field ensembles with lattice spacings $0.075, \; 0.05$ fm and pion masses $330,\;270$ MeV are used from the O($a$)- improved CLS 2-flavour simulations and the final state momentum is $|{\bf p}|=0.5\,{\rm GeV}$. The b-quark is treated in HQET including the $1/m_\mathrm{b}$ corrections. Fits to two-point and three-point correlation functions and suitable ratios including summed ratios are used, yielding consistent results with precision of around 2% which is $not$ limited by the $1/m_\mathrm{b}$ corrections but by the dominating static form factors. Excited state contributions are under reasonable control but are the bottleneck towards precision. We do not yet include a specific investigation of multi-hadron contaminations, a gap in the literature which ought to be filled soon., Comment: 38 pages, 23 figures

Published
2019
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5. Continuum limit of the leading order HQET form factor in $B_s \to K\ell\nu$ decays

Author

Bahr, Felix, Banerjee, Debasish, Bernardoni, Fabio, Joseph, Anosh, Koren, Mateusz, Simma, Hubert, and Sommer, Rainer

Subjects
High Energy Physics - Lattice
Abstract

We discuss the computation of form factors for semi-leptonic decays of $\rm B$-, $\rm B_s$- mesons in lattice QCD. Considering in particular the example of the static $\rm B_s$ form factors we demonstrate that after non-perturbative renormalization the continuum limit can be taken with confidence. The resulting precision is of interest for extractions of $V_{\rm ub}$. The size of the corrections of order $1/m_{\rm b}$ is just estimated at present but it is expected that their inclusion does not pose significant difficulties., Comment: 16 pages, 3 figures; minor corrections and typo fixes, published version

Published
2016
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6. B-meson spectroscopy in HQET at order 1/m

Author

Bernardoni, Fabio, Blossier, Benoît, Bulava, John, Della Morte, Michele, Fritzsch, Patrick, Garron, Nicolas, Gérardin, Antoine, Heitger, Jochen, von Hippel, Georg, and Simma, Hubert

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We present a study of the B spectrum performed in the framework of Heavy Quark Effective Theory expanded to next-to-leading order in 1/m and non-perturbative in the strong coupling. Our analyses have been performed on Nf=2 lattice gauge field ensembles corresponding to three different lattice spacings and a wide range of pion masses. We obtain the Bs-meson mass and hyperfine splittings of the B- and Bs-mesons that are in good agreement with the experimental values and examine the mass difference m_{Bs}-m_B as a further cross-check of our previous estimate of the b-quark mass. We also report on the mass splitting between the first excited state and the ground state in the B and Bs systems., Comment: 35 pages, 14 tables, 17 figures; Introduction extended and typos corrected. Version accepted for publication in PRD

Published
2015
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7. Form factors for $\mathrm B_\mathrm s \to \mathrm K \ell \nu$ decays in Lattice QCD

Author

Bahr, Felix, Bernardoni, Fabio, Bulava, John, Joseph, Anosh, Ramos, Alberto, Simma, Hubert, and Sommer, Rainer

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We present the current status of the computation of the form factor $f_+ (q^2)$ for the semi-leptonic decay $\mathrm B_\mathrm s \to \mathrm K \ell \nu$ by the ALPHA collaboration. We use gauge configurations which were generated as part of the Coordinated Lattice Simulations (CLS) effort. They have $N_\mathrm f=2$ non-perturbatively $O(a)$ improved Wilson fermions, and pion masses down to $\approx 250 \,\mathrm {MeV}$ with $m_\pi L \geq 4$. The heavy quark is treated in non-perturbative Heavy Quark Effective Theory (HQET). We discuss how to extract the form factors from the correlation functions and present first results for the form factor at $q^2 = 21.23\,\mathrm{GeV}^2$ extrapolated to the continuum. Next-to-leading order terms in HQET and the chiral extrapolation still need to be included in the analysis., Comment: 6 pages and 3 figures. Proceedings of the 8th International Workshop on the CKM Unitarity Triangle (CKM 2014), Vienna, Austria, September 8-12, 2014

Published
2014

9. Precision lattice QCD computation of the $B^*B\pi$ coupling

Author

Bernardoni, Fabio, Bulava, John, Donnellan, Michael, and Sommer, Rainer

Subjects
High Energy Physics - Lattice
Abstract

The static $B^{*}B\pi$ coupling, $\hat{g}_\chi$, a low energy constant in the leading order heavy meson chiral Lagrangian, is determined using $N_\mathrm{f} = 2$ lattice QCD. We use CLS ensembles with lattice spacings and pion masses down to $a = 0.05\mathrm{fm}$ and $m_{\pi}=270\mathrm{MeV}$, and perform combined continuum and chiral extrapolations of our results which have a much better accuracy than previous numbers in the literature. As a by-product, we determine the coupling between the first radial excitations in the $B$ and $B^{*}$ channels ($\hat{g}_{22}$). Accounting for all uncertainties, which are dominated by the chiral extrapolation, we obtain $\hat{g}_\chi = 0.492(29)$, while $\hat{g}_{22}$ is somewhat smaller. The comparison to a precise quenched computation suggests that there is little influence by the sea quarks and $\hat{g}_\chi$ will not change much when a dynamical strange quark is included., Comment: 14 pages, all included

Published
2014
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10. Metabolic state and value-based decision-making in acute and recovered female patients with anorexia nervosa

Author

Bernardoni, Fabio, Bernhardt, Nadine, Pooseh, Shakoor, King, Joseph A., Geisler, Daniel, Ritschel, Franziska, Boehm, Ilka, Seidel, Maria, Roessner, Veit, Smolka, Michael N., and Ehrlich, Stefan

Subjects
Aprotinin, Women's health, Medical research, Anorexia nervosa, Decision making, EDTA, Health, Psychology and mental health
Abstract

Background: Patients with anorexia nervosa forgo eating despite emaciation and severe health consequences. Such dysfunctional decision-making might be explained by an excessive level of self-control, alterations in homeostatic and hedonic regulation, or an interplay between these processes. We aimed to understand value-based decision-making in anorexia nervosa and its association with the gut hormone ghrelin. Besides its homeostatic function, ghrelin has been implicated in the hedonic regulation of appetite and reward via the modulation of phasic dopamine signalling. Methods: In a cross-sectional design, we studied acutely underweight (n = 94) and recovered (n = 37) patients with anorexia nervosa of the restrictive subtype, as well as healthy control participants (n = 119). We assessed plasma concentrations of desacyl ghrelin and parameters of delay discounting, probability discounting for gains and losses, and loss aversion. Results: Recovered patients displayed higher risk aversion for gains, but we observed no group differences for the remaining decision-making parameters. Desacyl ghrelin was higher in acutely underweight and recovered participants with anorexia nervosa relative to healthy controls. Moreover, we found a significant group x desacyl ghrelin interaction in delay discounting, indicating that in contrast to healthy controls, acutely underweight patients with anorexia nervosa who had high desacyl ghrelin concentrations preferably chose the delayed reward option. Limitations: We probed decision-making using monetary rewards, but patients with anorexia nervosa may react differently to disorder-relevant stimuli. Furthermore, in contrast to acyl ghrelin, the functions of desacyl ghrelin are unclear. Therefore, the interpretation of the results is preliminary. Conclusion: The propensity for risk aversion as found in recovered patients with anorexia nervosa could help them successfully complete therapy, or it could reflect sequelae of the disorder. Conversely, ghrelin findings might be related to a mechanism contributing to disease maintenance; that is, in acutely underweight anorexia nervosa, a hungry state may facilitate the ability to forgo an immediate reward to achieve a (dysfunctional) long-term goal., Introduction Anorexia nervosa is an eating disorder that frequently manifests during adolescence and is characterized by an intense fixation with body weight and self-starvation. Anorexia nervosa often takes a chronic [...]

Published
2020
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11. Intact value-based decision-making during intertemporal choice in women with remitted anorexia nervosa? An fMRI study

Author

King, Joseph A., Bernardoni, Fabio, Geisler, Daniel, Ritschel, Franziska, Doose, Arne, Pauligk, Sophie, Pasztor, Konrad, Weidner, Kerstin, Roessner, Veit, Smolka, Michael N., and Ehrlich, Stefan

Subjects
Shire Pharmaceuticals Group Ltd., Novartis AG, Medical research, Anorexia nervosa, Decision making, Pharmaceutical industry, Women, Magnetic resonance imaging, Eating disorders, Brain, Diseases, Health, Psychology and mental health
Abstract

Background: Extreme restrictive food choice in anorexia nervosa is thought to reflect excessive self-control and/or abnormal reward sensitivity. Studies using intertemporal choice paradigms have suggested an increased capacity to delay reward in anorexia nervosa, and this may explain an unusual ability to resist immediate temptation and override hunger in the long-term pursuit of thinness. It remains unclear, however, whether altered delay discounting in anorexia nervosa constitutes a state effect of acute illness or a trait marker observable after recovery. Methods: We repeated the analysis from our previous fMRI investigation of intertemporal choice in acutely underweight patients with anorexia nervosa in a sample of weight-recovered women with anorexia nervosa (n = 36) and age-matched healthy controls (n = 36) who participated in the same study protocol. Follow-up analyses explored functional connectivity separately in both the weight-recovered/healthy controls sample and the acute/healthy controls sample. Results: In contrast to our previous findings in acutely underweight patients with anorexia nervosa, we found no differences between weight-recovered patients with anorexia nervosa and healthy controls at either behavioural or neural levels. New analysis of data from the acute/healthy controls sample revealed increased coupling between dorsal anterior cingulate cortex and posterior brain regions as a function of decision difficulty, supporting the hypothesis of altered neural efficiency in the underweight state. Limitations: This was a cross-sectional study, and the results may be task-specific. Conclusion: Although our results underlined previous demonstrations of divergent temporal reward discounting in acutely underweight patients with anorexia nervosa, we found no evidence of alteration in patients with weight-recovered anorexia nervosa. Together, these findings suggest that impaired value-based decision-making may not constitute a defining trait variable or 'scar' of the disorder., Introduction Although many people have difficulty avoiding temptation from unhealthy foods and sticking to a nutritious diet, people with anorexia nervosa seem to resist hunger and restrict caloric intake with [...]

Published
2020
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12. B-physics from non-perturbatively renormalized HQET in two-flavour lattice QCD

Author

Bernardoni, Fabio, Blossier, Benoit, Bulava, John, Della Morte, Michele, Fritzsch, Patrick, Garron, Nicolas, Gerardin, Antoine, Heitger, Jochen, von Hippel, Georg M., and Simma, Hubert

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We report on the ALPHA Collaboration's lattice B-physics programme based on N_f=2 O(a) improved Wilson fermions and HQET, including all NLO effects in the inverse heavy quark mass, as well as non-perturbative renormalization and matching, to fix the parameters of the effective theory. Our simulations in large physical volume cover 3 lattice spacings a ~ (0.08-0.05) fm and pion masses down to 190 MeV to control continuum and chiral extrapolations. We present the status of results for the b-quark mass and the B_(s)-meson decay constants, f_B and f_{B_s}., Comment: Presented at the 16th International Conference in Quantum Chromodynamics (QCD 2012), 2-7 July 2012, Montpellier, France; 7 pages including figures, latex2e, uses elsarticle.cls

Published
2012
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13. B $\to$ $\pi$ form factor with 2 flavours of $O(a)$ improved Wilson quarks

Author

Bahr, Felix, Bernardoni, Fabio, Bulava, John, Ramos, Alberto, Simma, Hubert, and Sommer, Rainer

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

The determinations of $|V_{\rm ub}|$ from the exclusive branching ratios of $B\to \tau \nu$ and $B \to \pi l \nu$ tend to show a tension at the level of $3\sigma$ \cite{Beringer:1900zz}. On the theoretical side they depend on the lattice computation of the hadronic matrix elements $f_{\rm B}$ and the $B\to \pi$ form factor $f_+(q^2)$. To understand the tension, improved precision and a careful analysis of the systematics involved are necessary. Working towards this goal, we present preliminary lattice results of the ALPHA collaboration for the $B\to \pi$ form factor $f_+(q^2)$ with $N_{\rm f}=2$ flavours of $O(a)$-improved Wilson fermions. Our computation uses HQET in the static limit, pion masses ranging down to $\sim250$ MeV, large volumes with $m_\pi L >4$, three lattice spacings, and non-perturbative renormalization. We describe the techniques adopted to reduce the statistical noise (stochastic all-to-all with full time dilution) and the contamination from excited states (smearing for the B and the pion). We estimate the size of the chiral and continuum extrapolations. We discuss the impact our result could have to clarify the above mentioned discrepancy in the determination of $|V_{\rm ub}|$., Comment: 7 pages, 6 figures. proceedings for the 2012 lattice conference, cairns, australia

Published
2012

14. Determination of the Wilson ChPT low energy constant c_2

Author

Bernardoni, Fabio, Bulava, John, and Sommer, Rainer

Subjects
High Energy Physics - Lattice
Abstract

Following a suggestion by Aoki and B\"ar, c2 can be extracted by analyzing volume effects in 2-pion states. To this end we consider renormalized ratios of four point to two point correlation functions. We present the results from various CLS lattices, with pion masses ranging from 280 to 450 MeV and lattice spacings of 0.07 fm and 0.08 fm. This low energy constant is useful to understand discretization effects in chiral extrapolations with Wilson fermions, especially for quantities which vanish in the chiral limit, like the pion mass. Since our procedure is computationally cheap and straightforward, it is recommended as a routine study for any Wilson-type simulation, as a check of discretization effects., Comment: 6 pages, 5 figures, talk presented at the 2011 lattice conference, lake tahoe, california

Published
2011

15. Light quark correlators in a mixed-action setup

Author

Bernardoni, Fabio, Garron, Nicolas, Hernandez, Pilar, Necco, Silvia, and Pena, Carlos

Subjects
High Energy Physics - Lattice
Abstract

We report our progress in simulating Neuberger valence fermions on N_f=2 Wilson O(a)-improved sea quarks. We compute correlators with valence quark masses both in the p- and in the epsilon-regime, and we match the results with the predictions of the Chiral Effective Theory in the mixed regime. This allows us to extract the Low Energy Couplings (LECs) of the N_f=2 theory and to test the validity of the approach., Comment: 7 pages, 3 figures

Published
2011

16. Exploring the chiral regime of $N_f=2$ QCD with mixed actions

Author

Bernardoni, Fabio, Garron, Nicolas, Hernandez, Pilar, Necco, Silvia, and Pena, Carlos

Subjects
High Energy Physics - Lattice
Abstract

We report on our simulations with Neuberger valence fermions on CLS $N_f=2$ configurations with non-perturbatively $O(a)$-improved Wilson sea quarks. We consider the matching of QCD to ChPT in the so called mixed-regime in which the sea quarks are in the $p$-regime while the valence quarks are in the $\epsilon$-regime. From this matching, we can get information on $\Sigma$, $L_6$ and the combination $L_8+2L_6+2L_7$., Comment: 7 pages, 4 figures, Lattice 2010 proceedings

Published
2010

17. Probing the chiral regime of Nf=2 QCD with mixed actions

Author

Bernardoni, Fabio, Garron, Nicolas, Hernandez, Pilar, Necco, Silvia, and Pena, Carlos

Subjects
High Energy Physics - Lattice
Abstract

We report on our first experiences with a mixed action setup with overlap valence quarks and non-perturbatively O(a) improved Wilson sea quarks. For the latter we employ CLS Nf=2 configurations with light sea quark masses at small lattice spacings. Exact chiral symmetry allows to consider very light valence quarks and explore the matching to (partially quenched) Chiral Perturbation Theory (ChPT) in a mixed epsilon/p-regime. We compute the topological susceptibility and the low-lying spectrum of the massless Neuberger-Dirac operator for three values of the sea quark mass, and compare the sea quark mass dependence to NLO ChPT in the mixed regime. This provides two different determinations of the chiral condensate, as well as information about some NLO low-energy couplings. Our results allow to test the consistency of the mixed-regime approach to ChPT, as well as of the mixed action framework., Comment: 33 pages, 15 figures. v2: extended discussion of matching to Random Matrix Theory, minor changes in analysis; published version

Published
2010
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18. Finite-size scaling of heavy-light mesons

Author

Bernardoni, Fabio, Hernandez, Pilar, and Necco, Silvia

Subjects
High Energy Physics - Lattice
Abstract

We study the finite-size scaling of heavy-light mesons in the static limit. The most relevant effects are due to the pseudo-Goldstone boson cloud. In the HMChPT framework we compute two-point functions of left current densitities as well as pseudoscalar densitites for the cases in which some or all of them lay in the epsilon-regime. As expected, finite volume dependence turns out to be significant in this regime and can be predicted in the effective theory in terms of the infinite-volume low-energy couplings. These results might be relevant for extraction of heavy-light meson properties from lattice simulations., Comment: 7 pages, 2 figures, Contributed to 27th International Symposium on Lattice Field Theory, Beijing, China, 26 - 31 Jul 2009

Published
2009

19. Heavy-light mesons in the epsilon-regime

Author

Bernardoni, Fabio, Hernandez, Pilar, and Necco, Silvia

Subjects
High Energy Physics - Lattice
Abstract

We study the finite-size scaling of heavy-light mesons in the static limit. We compute two-point functions of chiral current densities as well as pseudoscalar densities in the epsilon-regime of heavy meson Chiral Perturbation Theory (HMChPT). As expected, finite volume dependence turns out to be significant in this regime and can be predicted in the effective theory in terms of the infinite-volume low-energy couplings. These results might be relevant for extraction of heavy-meson properties from lattice simulations., Comment: 32 pages, 4 figures

Published
2009
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20. Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa.

Author

Bahnsen, Klaas, Wronski, Marie‐Louis, Keeler, Johanna Louise, King, Joseph A., Preusker, Quirina, Kolb, Theresa, Weidner, Kerstin, Roessner, Veit, Bernardoni, Fabio, and Ehrlich, Stefan

Subjects
ANOREXIA nervosa, BODY image, BODY image disturbance, HIPPOCAMPUS (Brain), WEIGHT gain, MAGNETIC resonance imaging
Abstract

Background: Anorexia nervosa (AN) is a mental disorder characterized by dietary restriction, fear of gaining weight, and distorted body image. Recent studies indicate that the hippocampus, crucial for learning and memory, may be affected in AN, yet subfield‐specific effects remain unclear. We investigated hippocampal subfield alterations in acute AN, changes following weight restoration, and their associations with leptin levels. Methods: T1‐weighted magnetic resonance imaging scans were processed using FreeSurfer. We compared 22 left and right hemispheric hippocampal subfield volumes cross‐sectionally and longitudinally in females with acute AN (n = 165 at baseline, n = 110 after partial weight restoration), healthy female controls (HCs; n = 271), and females after long‐term recovery from AN (n = 79) using linear models. Results: We found that most hippocampal subfield volumes were significantly reduced in patients with AN compared with HCs (~−3.9%). Certain areas such as the subiculum exhibited no significant reduction in the acute state of AN, while other areas, such as the hippocampal tail, showed strong decreases (~−9%). Following short‐term weight recovery, most subfields increased in volume. Comparisons between participants after long‐term weight‐recovery and HC yielded no differences. The hippocampal tail volume was positively associated with leptin levels in AN independent of body mass index. Conclusions: Our study provides evidence of differential volumetric differences in hippocampal subfields between individuals with AN and HC and almost complete normalization after weight rehabilitation. These alterations are spatially inhomogeneous and more pronounced compared with other major mental disorders (e.g. major depressive disorder and schizophrenia). We provide novel insights linking hypoleptinemia to hippocampal subfield alterations hinting towards clinical relevance of leptin normalization in AN recovery. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Mapping the geometry of the E6 group

Author

Bernardoni, Fabio, Cacciatori, Sergio L., Cerchiai, Bianca L., and Scotti, Antonio

Subjects
Mathematical Physics, High Energy Physics - Theory
Abstract

In this paper we present a construction for the compact form of the exceptional Lie group E6 by exponentiating the corresponding Lie algebra e6, which we realize as the the sum of f4, the derivations of the exceptional Jordan algebra J3 of dimension 3 with octonionic entries, and the right multiplication by the elements of J3 with vanishing trace. Our parametrization is a generalization of the Euler angles for SU(2) and it is based on the fibration of E6 via a F4 subgroup as the fiber. It makes use of a similar construction we have performed in a previous article for F4. An interesting first application of these results lies in the fact that we are able to determine an explicit expression for the Haar invariant measure on the E6 group manifold., Comment: 30 pages

Published
2007
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22. Mapping the geometry of the F4 group

Author

Bernardoni, Fabio, Cacciatori, Sergio L., Cerchiai, Bianca L., and Scotti, Antonio

Subjects
Mathematical Physics, High Energy Physics - Theory, 22E46, 22E70
Abstract

In this paper we present a construction of the compact form of the exceptional Lie group F4 by exponentiating the corresponding Lie algebra f4. We realize F4 as the automorphisms group of the exceptional Jordan algebra, whose elements are 3 x 3 hermitian matrices with octonionic entries. We use a parametrization which generalizes the Euler angles for SU(2) and is based on the fibration of F4 via a Spin(9) subgroup as a fiber. This technique allows us to determine an explicit expression for the Haar invariant measure on the F4 group manifold. Apart from shedding light on the structure of F4 and its coset manifold OP2=F4/Spin(9), the octonionic projective plane, these results are a prerequisite for the study of E6, of which F4 is a (maximal) subgroup., Comment: 50 pages; some typos corrected

Published
2007

24. Mapping the geometry of the F4 group

Author

Bernardoni, Fabio

Subjects
Mathematics and Computing, Physics of elementary particles and fields, exceptional Lie groups, Haar measure, coset spaces, geometry
Abstract

In this paper, we present a construction of the compact form of the exceptional Lie group F4 by exponentiating the corresponding Lie algebra f4. We realize F4 as the automorphisms group of the exceptional Jordan algebra, whose elements are 3 x 3 Hermitian matrices with octonionic entries. We use a parametrization which generalizes the Euler angles for SU(2) and is based on the fibration of F4 via a Spin(9) subgroup as a fiber. This technique allows us to determine an explicit expression for the Haar invariant measure on the F4 group manifold. Apart from shedding light on the structure of F4 and its coset manifold OP2 = F4/Spin(9), the octonionic projective plane, these results are a prerequisite for the study of E6, of which F4 is a (maximal) subgroup.

Published
2009

26. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Author

Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, Francks, Clyde; https://orcid.org/0000-0002-9098-890X, Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, and Francks, Clyde; https://orcid.org/0000-0002-9098-890X

Abstract

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

Published
2023

27. Partially restored resting-state functional connectivity in women recovered from anorexia nervosa

Author

Boehm, Ilka, Geisler, Daniel, Tam, Friederike, King, Joseph A., Ritschel, Franziska, Seidel, Maria, Bernardoni, Fabio, Murr, Julia, Goschke, Thomas, Calhoun, Vince D., Roessner, Veit, and Ehrlich, Stefan

Subjects
Neural circuitry -- Health aspects, Anorexia nervosa -- Development and progression -- Physiological aspects, Cingulate cortex -- Health aspects, Health, Psychology and mental health
Abstract

Background: We have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and the default mode network (DMN) in patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC in patients recovered from anorexia nervosa to examine whether these abnormalities are a state or trait marker of the disease. To extend the understanding of functional connectivity in patients with anorexia nervosa, we also estimated rsFC between large-scale networks. Methods: Girls and women recovered from anorexia nervosa and pair-wise, age- and sex-matched healthy controls underwent a resting-state fMRI scan. Using independent component analyses (ICA), we isolated the FPN, DMN and salience network. We used standard comparisons as well as a hypothesis-based approach to test the findings of our previous rsFC study in this recovered cohort. Temporal correlations between network time-course pairs were computed to investigate functional network connectivity (FNC). Results: Thirty-one patients recovered from anorexia nervosa and 31 controls participated in our study. Standard group comparisons revealed reduced rsFC between the dorsolateral prefrontal cortex (dlPFC) and the FPN in the recovered group. Using a hypothesis-based approach we extended the previous finding of increased rsFC between the angular gyrus and the FPN in patients recovered from anorexia nervosa. No group differences in FNC were revealed. Limitations: The study design did not allow us to conclude that the difference found in rsFC constitutes a scar effect of the disease. Conclusion: This study suggests that some abnormal rsFC patterns found in patients recovered from anorexia nervosa normalize after long-term weight restoration, while distorted rsFC in the FPN, a network that has been associated with cognitive control, may constitute a trait marker of the disorder., Introduction Anorexia nervosa is a severe psychiatric disorder hallmarked by extreme weight loss (or failure to gain weight during growth) due to relentless control of food intake and has been [...]

Published
2016
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29. Altered White Matter Connectivity in Young Acutely Underweight Patients With Anorexia Nervosa

Author

Geisler, Daniel, King, Joseph A., Bahnsen, Klaas, Bernardoni, Fabio, Doose, Arne, Müller, Dirk K., Marxen, Michael, Roessner, Veit, van den Heuvel, Martijn, Ehrlich, Stefan, Geisler, Daniel, King, Joseph A., Bahnsen, Klaas, Bernardoni, Fabio, Doose, Arne, Müller, Dirk K., Marxen, Michael, Roessner, Veit, van den Heuvel, Martijn, and Ehrlich, Stefan

Abstract

Objective: Reductions of gray matter volume and cortical thickness in anorexia nervosa (AN) are well documented. However, findings regarding the integrity of white matter (WM) as studied via diffusion weighted imaging (DWI) are remarkably heterogeneous, and WM connectivity has been examined only in small samples using a limited number of regions of interest. The present study investigated whole-brain WM connectivity for the first time in a large sample of acutely underweight patients with AN. Method: DWI data from predominantly adolescent patients with acute AN (n ¼ 96, mean age ¼ 16.3 years) and age-matched healthy control participants (n ¼ 96, mean age ¼ 17.2 years) were analyzed. WM connectivity networks were generated from fiber-tractography-derived streamlines connecting 233 cortical/subcortical regions. To identify group differences, network-based statistic was used while taking head motion, WM, and ventricular volume into account. Results: Patients with AN were characterized by 6 WM subnetworks with abnormal architecture, as indicated by increased fractional anisotropy located primarily in parietal-occipital regions and accompanied by reduced radial diffusivity. Group differences based on number of streamlines reached only nominal significance. Conclusion: Our study reveals pronounced alterations in the WM connectome in young patients with AN. In contrast to known reductions in gray matter in the acutely underweight state of AN, this pattern does not necessarily indicate a deterioration of the WM network. Future studies using advanced MRI sequences will have to clarify interrelations with axonal packing or

Published
2022

30. Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa : A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Author

Walton, Esther, Bernardoni, Fabio, Batury, Victoria-Luise, Bahnsen, Klaas, Lariviere, Sara, Abbate-Daga, Giovanni, Andres-Perpina, Susana, Bang, Lasse, Bischoff-Grethe, Amanda, Brooks, Samantha, Campbell, Iain C., Cascino, Giammarco, Castro-Fornieles, Josefina, Collantoni, Enrico, D'Agata, Federico, Dahmen, Brigitte, Danner, Unna N., Favaro, Angela, Feusner, Jamie D., Frank, Guido K. W., Friederich, Hans-Christoph, Graner, John L., Herpertz-Dahlmann, Beate, Hess, Andreas, Horndasch, Stefanie, Kaplan, Allan S., Kaufmann, Lisa-Katrin, Kaye, Walter H., Khalsa, Sahib S., LaBar, Kevin S., Lavagnino, Luca, Lazaro, Luisa, Manara, Renzo, Miles, Amy E., Milos, Gabriella F., Monteleone, Alessio Maria, Monteleone, Palmiero, Mwangi, Benson, O'Daly, Owen, Pariente, Jose, Roesch, Julie, Schmidt, Ulrike H., Seitz, Jochen, Shott, Megan E., Simon, Joe J., Smeets, Paul A. M., Tamnes, Christian K., Tenconi, Elena, Thomopoulos, Sophia, I, van Elburg, Annemarie A., Voineskos, Aristotle N., von Polier, Georg G., Wierenga, Christina E., Zucker, Nancy L., Jahanshad, Neda, King, Joseph A., Thompson, Paul M., Berner, Laura A., Ehrlich, Stefan, Walton, Esther, Bernardoni, Fabio, Batury, Victoria-Luise, Bahnsen, Klaas, Lariviere, Sara, Abbate-Daga, Giovanni, Andres-Perpina, Susana, Bang, Lasse, Bischoff-Grethe, Amanda, Brooks, Samantha, Campbell, Iain C., Cascino, Giammarco, Castro-Fornieles, Josefina, Collantoni, Enrico, D'Agata, Federico, Dahmen, Brigitte, Danner, Unna N., Favaro, Angela, Feusner, Jamie D., Frank, Guido K. W., Friederich, Hans-Christoph, Graner, John L., Herpertz-Dahlmann, Beate, Hess, Andreas, Horndasch, Stefanie, Kaplan, Allan S., Kaufmann, Lisa-Katrin, Kaye, Walter H., Khalsa, Sahib S., LaBar, Kevin S., Lavagnino, Luca, Lazaro, Luisa, Manara, Renzo, Miles, Amy E., Milos, Gabriella F., Monteleone, Alessio Maria, Monteleone, Palmiero, Mwangi, Benson, O'Daly, Owen, Pariente, Jose, Roesch, Julie, Schmidt, Ulrike H., Seitz, Jochen, Shott, Megan E., Simon, Joe J., Smeets, Paul A. M., Tamnes, Christian K., Tenconi, Elena, Thomopoulos, Sophia, I, van Elburg, Annemarie A., Voineskos, Aristotle N., von Polier, Georg G., Wierenga, Christina E., Zucker, Nancy L., Jahanshad, Neda, King, Joseph A., Thompson, Paul M., Berner, Laura A., and Ehrlich, Stefan

Abstract

BACKGROUND: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and de-pendencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data. METHODS: We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251). RESULTS: In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of un-dernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients. CONCLUSIONS: The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.

Published
2022
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31. Virtual ontogeny of cortical growth preceding mental illness

Author

German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, Grotegerd, Dominik., German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, and Grotegerd, Dominik.

Abstract

[Background]: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life., [Methods]: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed., [Results]: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth., [Conclusions]: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

Published
2022

32. Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels

Author

Wronski, Marie-Louis, Geisler, Daniel, Bernardoni, Fabio, Seidel, Maria, Bahnsen, Klaas, Doose, Arne, Steinhäuser, Jonas L., Gronow, Franziska, Böldt, Luisa V., Plessow, Franziska, Lawson, Elizabeth A., King, Joseph A., Roessner, Veit, Ehrlich, Stefan, Wronski, Marie-Louis, Geisler, Daniel, Bernardoni, Fabio, Seidel, Maria, Bahnsen, Klaas, Doose, Arne, Steinhäuser, Jonas L., Gronow, Franziska, Böldt, Luisa V., Plessow, Franziska, Lawson, Elizabeth A., King, Joseph A., Roessner, Veit, and Ehrlich, Stefan

Abstract

Background The amygdala is a subcortical limbic structure consisting of histologically and functionally distinct subregions. New automated structural magnetic resonance imaging (MRI) segmentation tools facilitate the in vivo study of individual amygdala nuclei in clinical populations such as patients with anorexia nervosa (AN) who show symptoms indicative of limbic dysregulation. This study is the first to investigate amygdala nuclei volumes in AN, their relationships with leptin, a key indicator of AN-related neuroendocrine alterations, and further clinical measures. Methods T1-weighted MRI scans were subsegmented and multi-stage quality controlled using FreeSurfer. Left/right hemispheric amygdala nuclei volumes were cross-sectionally compared between females with AN (n = 168, 12–29 years) and age-matched healthy females (n = 168) applying general linear models. Associations with plasma leptin, body mass index (BMI), illness duration, and psychiatric symptoms were analyzed via robust linear regression. Results Globally, most amygdala nuclei volumes in both hemispheres were reduced in AN v. healthy control participants. Importantly, four specific nuclei (accessory basal, cortical, medial nuclei, corticoamygdaloid transition in the rostral-medial amygdala) showed greater volumetric reduction even relative to reductions of whole amygdala and total subcortical gray matter volumes, whereas basal, lateral, and paralaminar nuclei were less reduced. All rostral-medially clustered nuclei were positively associated with leptin in AN independent of BMI. Amygdala nuclei volumes were not associated with illness duration or psychiatric symptom severity in AN. Conclusions In AN, amygdala nuclei are altered to different degrees. Severe volume loss in rostral-medially clustered nuclei, collectively involved in olfactory/food-related reward processing, may represent a structural correlate of AN-related symptoms. Hypoleptinemia might be linked to rostral-medial amygdala alterations.

Published
2022

33. No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa

Author

Weinert, Tomas, Bernardoni, Fabio, King, Joseph, Steding, Julius, Boehm, Ilka, Mannigel, Merle, Ritschel, Franziska, Zepf, Florian, Roessner, Veit, Ehrlich, Stefan, Weinert, Tomas, Bernardoni, Fabio, King, Joseph, Steding, Julius, Boehm, Ilka, Mannigel, Merle, Ritschel, Franziska, Zepf, Florian, Roessner, Veit, and Ehrlich, Stefan

Abstract

Background Previous studies have suggested that individuals recovered from anorexia nervosa (AN) are characterized by increased serotonergic (5-HT) activity that might be related to elevated levels of anxiety. Assuming these traits to be also present in individuals at risk for AN, it was further hypothesized that restricting food intake might be a means to temporarily alleviate dysphoric affective states by reducing central nervous availability of tryptophan (TRP), the sole precursor of 5-HT. One study that supported this hypothesis found anxiolytic effects in individuals with a history of AN during an experimentally induced short-term depletion of TRP supply to the brain. Methods In this placebo-controlled, double-blind cross-over study, 22 patients weight-recovered from AN (recAN) and 25 healthy control participants (HC) completed questionnaires assessing anxiety and momentary mood during acute tryptophan depletion (ATD), a dietary intervention that lowers central 5-HT synthesis. Results The ATD procedure effectively reduced the ratio of TRP to competing for large neutral amino acids in the peripheral blood, indicating decreased TRP supply to the brain. Effects of ATD on anxiety and mood did not differ between recAN and HC. Bayesian null hypothesis testing confirmed these initial results. Discussion Our results do not support the hypothesis that short-term depletion of TRP and its impact on the brain 5-HT reduces anxiety or improves mood in AN. As the evidence for the role of 5-HT dysfunction on affective processes in patients with AN is limited, further studies are needed to assess its relevance in the pathophysiology of AN.

Published
2022

39. Processing and regulation of negative emotions in anorexia nervosa: An fMRI study

Author

Seidel, Maria, primary, King, Joseph A., additional, Ritschel, Franziska, additional, Boehm, Ilka, additional, Geisler, Daniel, additional, Bernardoni, Fabio, additional, Beck, Matthias, additional, Pauligk, Sophie, additional, Biemann, Ronald, additional, Strobel, Alexander, additional, Goschke, Thomas, additional, Walter, Henrik, additional, Roessner, Veit, additional, and Ehrlich, Stefan, additional

Published
2018
Full Text
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40. Alterations in White Matter-Integrity in Patients with Anorexia Nervosa - A Longitudinal Study

Author

Von Schwanenflug, Nina, Müller, Dirk K., Ehrlich, Stefan, Marxen, Michael, Bernardoni, Fabio, Geisler, Daniel, Mohammadi, Siawoosh, and King, Joseph

Subjects
ddc: 610, mental disorders, 610 Medical sciences, Medicine, behavioral disciplines and activities
Abstract

Background: Despite increasing interest in white matter alterations in patients with Anorexia Nervosa (AN), there are only a few and inconsistent studies. Especially, there is a lack of longitudinal study designs. Methods: We employ Diffusion-Tensor-Imaging (DTI; 36 diffusion sensitizing gradients;[for full text, please go to the a.m. URL], 5. Wissenschaftlicher Kongress der Deutschen Gesellschaft für Essstörungen

Published
2016

41. Preserved white matter microstructure in young patients with anorexia nervosa?

Author

Pfuhl, Gerit, King, Joseph A., Geisler, Daniel, Roschinski, Benjamin, Ritschel, Franziska, Seidel, Maria, Bernardoni, Fabio, Müller, Dirk K., White, Tonya, Roessner, Veit, Ehrlich, Stefan, Child and Adolescent Psychiatry / Psychology, and Radiology & Nuclear Medicine

Subjects
Adult, Aging, Anorexia Nervosa, Adolescent, Intelligence, Brain, Organ Size, Weight Gain, Magnetic Resonance Imaging, White Matter, Body Mass Index, Young Adult, Diffusion Tensor Imaging, Thinness, Multivariate Analysis, Image Processing, Computer-Assisted, Cluster Analysis, Humans, Female, Child, Research Articles, Algorithms
Abstract

A massive but reversible reduction of cortical thickness and subcortical gray matter (GM) volumes in Anorexia Nervosa (AN) has been recently reported. However, the literature on alterations in white matter (WM) volume and microstructure changes in both acutely underweight AN (acAN) and after recovery (recAN) is sparse and results are inconclusive. Here, T1-weighted and diffusion-weighted MRI data in a sizable sample of young and medication-free acAN (n = 35), recAN (n = 32), and age-matched female healthy controls (HC, n = 62) were obtained. For analysis, a well-validated global probabilistic tractography reconstruction algorithm including rigorous motion correction implemented in FreeSurfer: TRACULA (TRActs Constrained by UnderLying Anatomy) were used. Additionally, a clustering algorithm and a multivariate pattern classification technique to WM metrics to predict group membership were applied. No group differences in either WM volume or WM microstructure were detected with standard analysis procedures either in acAN or recAN relative to HC after controlling for the number of performed statistical tests. These findings were not affected by age, IQ, or psychiatric symptoms. While cluster analysis was unsuccessful at discriminating between groups, multivariate pattern classification showed some ability to separate acAN from HC (but not recAN from HC). However, these results were not compatible with a straightforward hypothesis of impaired WM microstructure. The current findings suggest that WM integrity is largely preserved in non-chronic AN. This finding stands in contrast to findings in GM, but may help to explain the relatively intact cognitive performance of young patients with AN and provide the basis for the fast recovery of GM structures. Hum Brain Mapp 37:4069-4083, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

44. B-meson spectroscopy in HQET at order1/m

Author

Bernardoni, Fabio, Blossier, Benoît, Bulava, John, Della Morte, Michele, Fritzsch, Patrick, Garron, Nicolas, Gérardin, Antoine, Heitger, Jochen, Von Hippel, Georg, Simma, Hubert, ALPHA Collaboration, and UAM. Departamento de Física Teórica

Subjects
Physics, Nuclear and High Energy Physics, European community, High Energy Physics::Lattice, High Energy Physics - Lattice (hep-lat), High Energy Physics::Phenomenology, FOS: Physical sciences, Física, Library science, language.human_language, German, Nuclear physics, High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), High Energy Physics - Lattice, language, Strong coupling, Heavy quark effective theory, ddc:530, Christian ministry, Partial support, Computer resources
Abstract

We present a study of the B spectrum performed in the framework of heavy quark effective theory expanded to next-to-leading order in 1/mb and nonperturbative in the strong coupling. Our analyses have been performed on Nf=2 lattice gauge field ensembles corresponding to three different lattice spacings and a wide range of pion masses. We obtain the Bs-meson mass and hyperfine splittings of the B- and Bs-mesons that are in good agreement with the experimental values and examine the mass difference mBs-mB as a further cross-check of our previous estimate of the b-quark mass. We also report on the mass splitting between the first excited state and the ground state in the B and Bs systems, We acknowledge partial support by the SFB/TR 9, by Grants No. HE 4517/2-1 (P. F. and J. H.) and No. HE 4517/3-1 (J. H.) of the Deutsche Forschungsgemeinschaft, by the European Community through EU Contract No. MRTN-CT-2006-035482, “FLAVIAnet,” by the Spanish Minister of Education and Science projects RyC-2011-08557 and by the Danish National Research Foundation under Grant No. DNRF:90 (M. D. M.). P. F. acknowledges financial support from the Spanish MINECO under Grants No. FPA2012-31880 and No. SEV-2012-0249 (“Centro de Excelencia Severo Ochoa” Programme). N. G. is supported by the Leverhulme trust, research Grant No. RPG-2014-118. We gratefully acknowledge the computer resources granted by the John von Neumann Institute for Computing (NIC) and provided on the supercomputer JUROPA at Jülich Supercomputing Centre (JSC) and by the Gauss Centre for Supercomputing (GCS) through the NIC on the GCS share of the supercomputer JUQUEEN at JSC, with funding by the German Federal Ministry of Education and Research (BMBF) and the German State Ministries for Research of Baden-Württemberg (MWK), Bayern (StMWFK) and Nordrhein-Westfalen (MIWF), as well as within the Distributed European Computing Initiative by the PRACE-2IP, with funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under Grant Agreement No. RI-283493, by the Grand Équipement National de Calcul Intensif at CINES in Montpellier under the allocation 2012-056808, by the HLRN in Berlin, and by NIC at DESY, Zeuthen

Published
2015

45. Precision lattice QCD Computation of the ${B}^{⁎}B\pi $ Coupling

Author

Bernardoni, Fabio, ALPHA Collaboration, Bulava, John, Sommer, Rainer, and Donnellan, Michael

Subjects
High Energy Physics - Lattice, High Energy Physics::Lattice, High Energy Physics::Phenomenology, ddc:530
Abstract

The static $B^{*}B\pi$ coupling, $\hat{g}_\chi$, a low energy constant in the leading order heavy meson chiral Lagrangian, is determined using $N_\mathrm{f} = 2$ lattice QCD. We use CLS ensembles with lattice spacings and pion masses down to $a = 0.05\mathrm{fm}$ and $m_{\pi}=270\mathrm{MeV}$, and perform combined continuum and chiral extrapolations of our results which have a much better accuracy than previous numbers in the literature. As a by-product, we determine the coupling between the first radial excitations in the $B$ and $B^{*}$ channels ($\hat{g}_{22}$). Accounting for all uncertainties, which are dominated by the chiral extrapolation, we obtain $\hat{g}_\chi = 0.492(29)$, while $\hat{g}_{22}$ is somewhat smaller. The comparison to a precise quenched computation suggests that there is little influence by the sea quarks and $\hat{g}_\chi$ will not change much when a dynamical strange quark is included., Comment: 14 pages, all included

Published
2015

47. The b-quark mass from non-perturbative Nf = 2 Heavy Quark Effective Theory at O(1/mh)

Author

Bernardoni, Fabio, Della Morte, Michele, Sommer, Rainer, and SCOAP

Subjects
Heavy Quark Effective Theory, Lattice QCD, b-quark mass
Abstract

Bernardoni, Fabio et al., We report our final estimate of the b-quark mass from Nf=2 lattice QCD simulations using Heavy Quark Effective Theory non-perturbatively matched to QCD at O(1/mh). Treating systematic and statistical errors in a conservative manner, we obtain View the MathML source after an extrapolation to the physical point., This work is supported in part by the SFB/TR 9, by grant HE 4517/2-1 (P.F. and J.H.) and HE 4517/3-1 (J.H.), of the Deutsche Forschungsgemeinschaft, and by the European Community through EU Contract MRTN-CT-2006-035482, “FLAVIAnet”. It was also partially supported by the Spanish Minister of Education and Science project RyC-2011-08557 (M.D.M.). P.F. and R.S. thank the ECT* in Trento for support during the workshop “Beautiful Mesons and Baryons on the Lattice”. We thank our colleagues in the CLS effort for the joint production and use of gauge configurations. We gratefully acknowledge the computer resources granted by the John von Neumann Institute for Computing (NIC) and provided on the supercomputer JUROPA at Jülich Supercomputing Centre (JSC) and by the Gauss Centre for Supercomputing (GCS) through the NIC on the GCS share of the supercomputer JUQUEEN at JSC, with funding by the German Federal Ministry of Education and Research (BMBF) and the German State Ministries for Research of Baden–Württemberg (MWK), Bayern (StMWFK) and Nordrhein–Westfalen (MIWF), as well as within the Distributed European Computing Initiative by the PRACE-2IP, with funding from the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement RI-283493, by the Grand Équipement National de Calcul Intensif at CINES in Montpellier under the allocation 2012-056808, by the HLRN in Berlin, and by NIC at DESY, Zeuthen.

Published
2014

48. The b-quark mass from non-perturbative ${N}_{\mathrm{f}}=2$ Heavy Quark Effective Theory at $\mathrm{O}\left(1/{m}_{\mathrm{h}}\right)$Bloss

Author

Bernardoni, Fabio, Blossier, Benoit, Sommer, Rainer, Bulava, John, Morte, Michele Della, Fritzsch, Patrick, Garron, Nicolas, Gérardin, Antoine, Heitger, Jochen, Hippel, Georg von, and Simma, Hubert

Subjects
High Energy Physics::Lattice, High Energy Physics::Phenomenology, High Energy Physics::Experiment, ddc:530, Nuclear Experiment
Abstract

We report our final estimate of the b-quark mass from N f = 2 lattice QCD simulations using Heavy QuarkEffective Theory non-perturbatively matched to QCD at O ( 1 / m h ) . Treating systematic and statistical errorsin a conservative manner, we obtain m MS( 2 GeV ) = 4 . 88 ( 15 ) GeV after an extrapolation to the physicalbpoint.

Published
2014

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