Search

Your search keyword '"Bicknell, R"' showing total 392 results
Start Over Author "Bicknell, R" Search Limiters Full Text
392 results on '"Bicknell, R"'

2. Evaluation of IMproving Palliative care Education and Training Using Simulation in Dementia (IMPETUS-D) a staff simulation training intervention to improve palliative care of people with advanced dementia living in nursing homes: a cluster randomised cont

Author

Tropea, J, Nestel, D, Johnson, C, Hayes, BJ, Hutchinson, Ana, Brand, C, Le, BH, Blackberry, I, Caplan, GA, Bicknell, R, Hepworth, G, Lim, WK, Tropea, J, Nestel, D, Johnson, C, Hayes, BJ, Hutchinson, Ana, Brand, C, Le, BH, Blackberry, I, Caplan, GA, Bicknell, R, Hepworth, G, and Lim, WK

Abstract

BACKGROUND: People with dementia have unique palliative and end-of-life needs. However, access to quality palliative and end-of-life care for people with dementia living in nursing homes is often suboptimal. There is a recognised need for nursing home staff training in dementia-specific palliative care to equip them with knowledge and skills to deliver high quality care. OBJECTIVE: The primary aim was to evaluate the effectiveness of a simulation training intervention (IMPETUS-D) aimed at nursing home staff on reducing unplanned transfers to hospital and/or deaths in hospital among residents living with dementia. DESIGN: Cluster randomised controlled trial of nursing homes with process evaluation conducted alongside. SUBJECTS & SETTING: One thousand three hundred four people with dementia living in 24 nursing homes (12 intervention/12 control) in three Australian cities, their families and direct care staff. METHODS: Randomisation was conducted at the level of the nursing home (cluster). The allocation sequence was generated by an independent statistician using a computer-generated allocation sequence. Staff from intervention nursing homes had access to the IMPETUS-D training intervention, and staff from control nursing homes had access to usual training opportunities. The predicted primary outcome measure was a 20% reduction in the proportion of people with dementia who had an unplanned transfer to hospital and/or death in hospital at 6-months follow-up in the intervention nursing homes compared to the control nursing homes. RESULTS: At 6-months follow-up, 128 (21.1%) people with dementia from the intervention group had an unplanned transfer or death in hospital compared to 132 (19.0%) residents from the control group; odds ratio 1.14 (95% CI, 0.82-1.59). There were suboptimal levels of staff participation in the training intervention and several barriers to participation identified. CONCLUSION: This study of a dementia-specific palliative care staff training i

Published
2022

3. Evaluation of IMproving Palliative care Education and Training Using Simulation in Dementia (IMPETUS-D) a staff simulation training intervention to improve palliative care of people with advanced dementia living in nursing homes: a cluster randomised controlled trial

Author

Tropea, J, Nestel, D, Johnson, C, Hayes, BJ, Hutchinson, AF, Brand, C, Le, BH, Blackberry, I, Caplan, GA, Bicknell, R, Hepworth, G, Lim, WK, Tropea, J, Nestel, D, Johnson, C, Hayes, BJ, Hutchinson, AF, Brand, C, Le, BH, Blackberry, I, Caplan, GA, Bicknell, R, Hepworth, G, and Lim, WK

Abstract

BACKGROUND: People with dementia have unique palliative and end-of-life needs. However, access to quality palliative and end-of-life care for people with dementia living in nursing homes is often suboptimal. There is a recognised need for nursing home staff training in dementia-specific palliative care to equip them with knowledge and skills to deliver high quality care. OBJECTIVE: The primary aim was to evaluate the effectiveness of a simulation training intervention (IMPETUS-D) aimed at nursing home staff on reducing unplanned transfers to hospital and/or deaths in hospital among residents living with dementia. DESIGN: Cluster randomised controlled trial of nursing homes with process evaluation conducted alongside. SUBJECTS & SETTING: One thousand three hundred four people with dementia living in 24 nursing homes (12 intervention/12 control) in three Australian cities, their families and direct care staff. METHODS: Randomisation was conducted at the level of the nursing home (cluster). The allocation sequence was generated by an independent statistician using a computer-generated allocation sequence. Staff from intervention nursing homes had access to the IMPETUS-D training intervention, and staff from control nursing homes had access to usual training opportunities. The predicted primary outcome measure was a 20% reduction in the proportion of people with dementia who had an unplanned transfer to hospital and/or death in hospital at 6-months follow-up in the intervention nursing homes compared to the control nursing homes. RESULTS: At 6-months follow-up, 128 (21.1%) people with dementia from the intervention group had an unplanned transfer or death in hospital compared to 132 (19.0%) residents from the control group; odds ratio 1.14 (95% CI, 0.82-1.59). There were suboptimal levels of staff participation in the training intervention and several barriers to participation identified. CONCLUSION: This study of a dementia-specific palliative care staff training inter

Published
2022

8. Simulation training in non-cancer palliative care for healthcare workers: a systematic review of controlled studies

Author

Tropea, J, Bicknell, R, Nestel, D, Brand, CA, Johnson, CE, Paul, SK, Le, BH, Lim, WK, Tropea, J, Bicknell, R, Nestel, D, Brand, CA, Johnson, CE, Paul, SK, Le, BH, and Lim, WK

Abstract

BACKGROUND: The need for healthcare workers (HCWs) to have skills and knowledge in non-cancer palliative care has been recognised. Simulation is increasingly being used for palliative care training, offering participants the opportunity to learn in a realistic environment and fully interactive way. OBJECTIVE: The aim of this systematic review was to summarise and critically appraise controlled studies on simulation training in non-cancer palliative care for HCWs. SELECTION: Medline, CINAHL, PubMed and Cochrane Library databases were searched using palliative care and simulation terms. Randomised controlled trials (RCTs), non-randomised RCTs and controlled before-and-after (CBA) studies were included. Two reviewers independently screened titles and abstracts and undertook full article review using predefined selection criteria. Studies that met the inclusion criteria had data extracted and risk of bias assessed using the Cochrane Effective Practice and Organisation of Care risk of bias criteria. FINDINGS: Five articles were included: three RCTs and two CBA studies. All studies assessed learners' palliative care communication skills, most studies evaluated learners' perception of change in skills and one study assessed impact on patient outcomes and learners' change in behaviour when applied in practice. There was variation in intervention content, intensity and duration, outcome measures and study design, making it difficult to compare and synthesise results. CONCLUSION: There is a paucity of evidence to support simulation training to improve non-cancer palliative care. This review highlights the need for more robust research, including multicentre studies that use standardised outcome measures to assess clinician skills, changes in clinical practice and patient-related outcomes.

Published
2021

12. A study protocol for the development of a multivariable model predicting 6- and 12-month mortality for people with dementia living in residential aged care facilities (RACFs) in Australia.

Author

Bicknell, R, Lim, WK, Maier, AB, LoGiuidice, D, Bicknell, R, Lim, WK, Maier, AB, and LoGiuidice, D

Abstract

BACKGROUND: For residential aged care facility (RACF) residents with dementia, lack of prognostic guidance presents a significant challenge for end of life care planning. In an attempt to address this issue, models have been developed to assess mortality risk for people with advanced dementia, predominantly using long-term care minimum data set (MDS) information from the USA. A limitation of these models is that the information contained within the MDS used for model development was not collected for the purpose of identifying prognostic factors. The models developed using MDS data have had relatively modest ability to discriminate mortality risk and are difficult to apply outside the MDS setting. This study will aim to develop a model to estimate 6- and 12-month mortality risk for people with dementia from prognostic indicators recorded during usual clinical care provided in RACFs in Australia. METHODS: A secondary analysis will be conducted for a cohort of people with dementia from RACFs participating in a cluster-randomized trial of a palliative care education intervention (IMPETUS-D). Ten prognostic indicator variables were identified based on a literature review of clinical features associated with increased mortality for people with dementia living in RACFs. Variables will be extracted from RACF files at baseline and mortality measured at 6 and 12 months after baseline data collection. A multivariable logistic regression model will be developed for 6- and 12-month mortality outcome measures using backwards elimination with a fractional polynomial approach for continuous variables. Internal validation will be undertaken using bootstrapping methods. Discrimination of the model for 6- and 12-month mortality will be presented as receiver operating curves with c statistics. Calibration curves will be presented comparing observed and predicted event rates for each decile of risk as well as flexible calibration curves derived using loess-based functions. DISCUSSION

Published
2020

18. Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma

Author

Lupino, L, Perry, T, Margielewska, S, Hollows, R, Ibrahim, M, Care, M, Allegood, J, Tooze, R, Sabbadini, R, Reynolds, G, Bicknell, R, Rudzki, Z, Lin Hock, Y, Zanetto, U, Wei, W, Simmons, W, Spiegel, S, Woodman, CBJ, Rowe, M, Vrzalikova, K, and Murray, PG

Subjects
Neovascularization, Pathologic, Computational Biology, Endothelial Cells, S1P, SPHK1, Immunohistochemistry, Article, Gene Expression Regulation, Neoplastic, Disease Models, Animal, Mice, HUVEC, Sphingosine, immune system diseases, DLBCL, Cell Line, Tumor, hemic and lymphatic diseases, Animals, Humans, lipids (amino acids, peptides, and proteins), Lymphoma, Large B-Cell, Diffuse, RNA, Messenger, Lysophospholipids, Transcriptome, Signal Transduction
Abstract

Although the over-expression of angiogenic factors is reported in diffuse large B-cell lymphoma (DLBCL), the poor response to anti-VEGF drugs observed in clinical trials suggests that angiogenesis in these tumours might be driven by VEGF-independent pathways. We show that sphingosine kinase-1 (SPHK1), which generates the potent bioactive sphingolipid sphingosine-1-phosphate (S1P), is over-expressed in DLBCL. A meta-analysis of over 2000 cases revealed that genes correlated with SPHK1 mRNA expression in DLBCL were significantly enriched for tumour angiogenesis meta-signature genes; an effect evident in both major cell of origin (COO) and stromal subtypes. Moreover, we found that S1P induces angiogenic signalling and a gene expression programme that is present within the tumour vasculature of SPHK1-expressing DLBCL. Importantly, S1PR1 functional antagonists, including Siponimod, and the S1P neutralising antibody, Sphingomab, inhibited S1P signalling in DLBCL cells in vitro. Furthermore, Siponimod, also reduced angiogenesis and tumour growth in an S1P-producing mouse model of angiogenic DLBCL. Our data define a potential role for S1P signalling in driving an angiogenic gene expression programme in the tumour vasculature of DLBCL and suggest novel opportunities to target S1P-mediated angiogenesis in patients with DLBCL.

Published
2019

20. A screen-based simulation training program to improve palliative care of people with advanced dementia living in residential aged care facilities and reduce hospital transfers: Study protocol for the IMproving Palliative care Education and Training Using Simulation in Dementia (IMPETUS-D) cluster randomised controlled trial.

Author

Tropea J., Johnson C.E., Nestel D., Paul S.K., Brand C.A., Hutchinson A.F., Bicknell R., Lim W.K., Tropea J., Johnson C.E., Nestel D., Paul S.K., Brand C.A., Hutchinson A.F., Bicknell R., and Lim W.K.

Abstract

Background: Many people with advanced dementia live in residential aged care homes. Care home staff need the knowledge and skills to provide high-quality end-of-life (EOL) dementia care. However, several studies have found EOL dementia care to be suboptimal, and care staff have reported they would benefit from training in palliative care and dementia. Simulation offers an immersive learning environment and has been shown to improve learners' knowledge and skills. However, there is little research on simulation training for residential care staff. This article presents the development and evaluation protocol of IMproving Palliative care Education and Training Using Simulation in Dementia (IMPETUS-D) - a screen-based simulation training program on palliative dementia care, targeted at residential care staff. IMPETUS-D aims to improve the quality of palliative care provided to people living with dementia in residential care homes, including avoiding unnecessary transfers to hospital. Method(s): A cluster RCT will assess the effect of IMPETUS-D. Twenty-four care homes (clusters) in three Australian cities will be randomised to receive either the IMPETUS-D intervention or usual training opportunities (control). The primary outcome is to reduce transfers to hospital and deaths in hospital by 20% over 6-months in the intervention compared to the control group. Secondary outcomes include uptake of goals of care plans over 6 and 12 months, change in staff knowledge and attitudes towards palliative dementia care over 6 months, change in transfers to hospital and deaths in hospital over 12 months. For the primary analysis logistic regression models will be used with standard errors weighted by the cluster effects. A mixed methods process evaluation will be conducted alongside the cluster RCT to assess the mechanisms of impact, the implementation processes and contextual factors that may influence the delivery and effects of the intervention. Discussion(s): In Australia, the ne

Published
2019

21. A screen-based simulation training program to improve palliative care of people with advanced dementia living in residential aged care facilities and reduce hospital transfers: study protocol for the IMproving Palliative care Education and Training Using Simulation in Dementia (IMPETUS-D) cluster randomised controlled trial

Author

Tropea, J, Johnson, CE, Nestel, D, Paul, SK, Brand, CA, Hutchinson, AF, Bicknell, R, Lim, WK, Tropea, J, Johnson, CE, Nestel, D, Paul, SK, Brand, CA, Hutchinson, AF, Bicknell, R, and Lim, WK

Abstract

BACKGROUND: Many people with advanced dementia live in residential aged care homes. Care home staff need the knowledge and skills to provide high-quality end-of-life (EOL) dementia care. However, several studies have found EOL dementia care to be suboptimal, and care staff have reported they would benefit from training in palliative care and dementia. Simulation offers an immersive learning environment and has been shown to improve learners' knowledge and skills. However, there is little research on simulation training for residential care staff. This article presents the development and evaluation protocol of IMproving Palliative care Education and Training Using Simulation in Dementia (IMPETUS-D) - a screen-based simulation training program on palliative dementia care, targeted at residential care staff. IMPETUS-D aims to improve the quality of palliative care provided to people living with dementia in residential care homes, including avoiding unnecessary transfers to hospital. METHODS: A cluster RCT will assess the effect of IMPETUS-D. Twenty-four care homes (clusters) in three Australian cities will be randomised to receive either the IMPETUS-D intervention or usual training opportunities (control). The primary outcome is to reduce transfers to hospital and deaths in hospital by 20% over 6-months in the intervention compared to the control group. Secondary outcomes include uptake of goals of care plans over 6 and 12 months, change in staff knowledge and attitudes towards palliative dementia care over 6 months, change in transfers to hospital and deaths in hospital over 12 months. For the primary analysis logistic regression models will be used with standard errors weighted by the cluster effects. A mixed methods process evaluation will be conducted alongside the cluster RCT to assess the mechanisms of impact, the implementation processes and contextual factors that may influence the delivery and effects of the intervention. DISCUSSION: In Australia, the need fo

Published
2019

28. Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Author

Sprague, S. (Sheila), Schemitsch, E.H. (Emil H.), Swiontkowski, M.F. (Marc ), Della Rocca, G.J. (Gregory J.), Jeray, K.J. (Kyle J.), Liew, S. (Susan), Slobogean, G.P. (Gerard P.), Bzovsky, S. (Sofia), Heels-Ansdell, D. (Diane), Zhou, Q. (Qi), Bhandari, M. (Mohit), Sprag, S. (Sheila), Devereaux, P.J., Guyatt, G.H. (Gordon), Heetveld, M.J. (Martin J.), Richardson, M. (Martin), Thabane, L. (Lehana), Tornetta III, P. (Paul), Walter, S.D. (Stephen D.), McKay, P. (Paula), Scott, T. (Taryn), Garibaldi, A. (Alisha), Viveiros, H. (Helena), Swinton, M. (Marilyn), Gichuru, M. (Mark), Buckingham, L. (Lisa), Duraikannan, A. (Aravin), Maddock, D. (Deborah), Simunovic, N. (Nicole), Agel, J. (Julie), Lieshout, E.M.M. (Esther) van, Zielinski, S.M. (Stephanie), Rangan, A. (Amar), Hanusch, B.C. (Birgit C.), Kottam, L. (Lucksy), Clarkson, R. (Rachel), Haverlag, R. (Robert), McCormack, R. (Robert), Apostle, K. (Kelly), Boyer, D. (Dory), Moola, F. (Farhad), Perey, B. (Bertrand), Stone, T. (Trevor), Viskontas, D. (Darius), Lemke, H.M. (H. Michael), Zomar, M. (Mauri), Moon, K. (Karyn), Moon, R. (Raely), Oatt, A. (Amber), Buckley, R.E. (Richard E.), Duffy, P. (Paul), Korley, R. (Robert), Puloski, S. (Shannon), Powell, J. (James), Johnston, K. (Kelly), Carcary, K. (Kimberly), Lorenzo, M. (Melissa), McKercher, R. (Ross), Sanders, D. (David), MacLeod, M. (Mark), Lawendy, A.-R. (Abdel-Rahman), Tieszer, C. (Christina), Stephen, D. (David), Kreder, H. (Hans), Jenkinson, R. (Richard), Nousiainen, M. (Markku), Axelrod, T. (Terry), Murnaghan, J. (John), Nam, D. (Diane), Wadey, V. (Veronica), Yee, A. (Albert), Milner, K. (Katrine), Kunz, M. (Monica), Ghent, W. (Wesley), McKee, M.D. (Michael D.), Hall, J.A. (Jeremy A.), Nauth, A. (Aaron), Ahn, H. (Henry), Whelan, D.B. (Daniel B.), Vicente, M.R. (Milena R.), Wild, L.M. (Lisa M.), Khan, R.M. (Ryan M.), Hidy, J.T. (Jennifer T.), Coles, C. (Chad), Leighton, R. (Ross), Biddulph, M. (Michael), Johnston, D. (David), Glazebrook, M. (Mark), Alexander, D. (David), Coady, C. (Catherine), Dunbar, M. (Michael), Amirault, J.D. (J. David), Gross, M. (Michael), Oxner, W. (William), Reardon, G. (Gerald), Richardson, C.G. (C. Glen), Trenholm, J.A. (J. Andrew), Wong, I. (Ivan), Trask, K. (Kelly), MacDonald, S. (Shelley), Dobbin, G. (Gwendolyn), Bicknell, R. (Ryan), Yach, J. (Jeff), Bardana, D. (Davide), Wood, G. (Gavin), Harrison, M. (Mark), Yen, D. (David), Lambert, S. (Sue), Howells, F. (Fiona), Ward, A. (Angela), Zalzal, P. (Paul), Brien, H. (Heather), Naumetz, V. (V.), Weening, B. (Brad), Wai, E.K. (Eugene K.), Papp, S. (Steve), Gofton, W.T. (Wade T.), Liew, A. (Allen), Kingwell, S.P. (Stephen P.), Johnson, G. (Garth), O'Neil, J. (Joseph), Roffey, D.M. (Darren M.), Borsella, V. (Vivian), Avram, V. (Victoria), Oliver, T.M. (Todd M.), Jones, V. (Vicki), Vogt, M. (Michelle), Jones, C.B. (Clifford B.), Ringler, J.R. (James R.), Endres, T.J. (Terrence J.), Sietsema, D.L. (Debra L.), Walker, J.E. (Jane E.), Broderick, J.S. (J. Scott), Goetz, D.R. (David R.), Pace, T.B. (Thomas B.), Schaller, T.M. (Thomas M.), Porter, S.E. (Scott E.), Beckish, M.L. (Michael L.), Adams, J.D. (John D.), Barden, B.B. (Benjamin B.), Creek, A.T. (Aaron T.), Finley, S.H. (Stephen H.), Foret, J.L. (Jonathan L.), Gudger, G.K. (Garland K.), Gurich, R.W. (Richard W.), Hill, A.D. (Austin D.), Hollenbeck, S.M. (Steven M.), Jackson, L.T. (Lyle T.), Kruse, K.K. (Kevin K.), Lackey, W.G. (Wesley G.), Langan, J.W. (Justin W.), Lee, J. (Julia), Leffler, L.C. (Lauren C.), Miller, T.J. (Timothy J.), Murphy, R.L. (R. Lee), O'Malley, L.K. (Lawrence K.), Peters, M.E. (Melissa E.), Price, D.M. (Dustin M.), Tanksley, J.A. (John A.), Torres, E.T. (Erick T.), Watson, D.J. (Dylan J.), Watson, S.T. (Scott T.), Tanner, S.L. (Stephanie L.), Snider, R.G. (Rebecca G.), Nastoff, L.A. (Lauren A.), Bielby, S.A. (Shea A.), Teasdall, R.J. (Robert J.), Switzer, J.A. (Julie A.), Cole, P.A. (Peter A.), Anderson, S.A. (Sarah A.), Lafferty, P.M. (Paul M.), Li, M. (Mengnai), Ly, T.V. (Thuan V.), Marston, S.B. (Scott B.), Foley, A.L. (Amy L.), Vang, S. (Sandy), Wright, D.M. (David M.), Marcantonio, A.J. (Andrew J.), Kain, M.S.H. (Michael S.H.), Iorio, R. (Richard), Specht, L.M. (Lawrence M.), Tilzey, J.F. (John F.), Lobo, M.J. (Margaret J.), Garfi, J.S. (John S.), Vallier, H.A. (Heather A.), Dolenc, A. (Andrea), Breslin, M. (Mary), Prayson, M.J. (Michael J.), Laughlin, R. (Richard), Rubino, L.J. (L. Joseph), May, J. (Jedediah), Rieser, G.R. (Geoffrey Ryan), Dulaney-Cripe, L. (Liz), Gayton, C. (Chris), Shaer, J. (James), Schrickel, T. (Tyson), Hileman, B. (Barbara), Gorczyca, J.T. (John T.), Gross, J.M. (Jonathan M.), Humphrey, C.A. (Catherine A.), Kates, S. (Stephen), Ketz, J.P. (John P.), Noble, K. (Krista), McIntyre, A.W. (Allison W.), Pecorella, K. (Kaili), Davis, C.A. (Craig A.), Weinerman, S. (Stuart), Weingarten, P. (Peter), Stull, P. (Philip), Lindenbaum, S. (Stephen), Hewitt, M. (Michael), Schwappach, J. (John), Baker, J.K. (Janell K.), Rutherford, T. (Tori), Newman, H. (Heike), Lieberman, S. (Shane), Finn, E. (Erin), Robbins, K. (Kristin), Hurley, M. (Meghan), Lyle, L. (Lindsey), Mitchell, K. (Khalis), Browner, K. (Kieran), Whatley, E. (Erica), Payton, K. (Krystal), Reeves, C. (Christina), Cannada, L.K. (Lisa K.), Karges, D.E. (David E.), Dawson, S.A. (Sarah A.), Mehta, S. (Samir), Esterhai, J. (John), Ahn, J. (Jaimo), Donegan, D. (Derek), Horan, A.D. (Annamarie D.), Hesketh, P.J. (Patrick J.), Bannister, E.R. (Evan R.), Keeve, J.P. (Jonathan P.), Anderson, C.G. (Christopher G.), McDonald, M.D. (Michael D.), Hoffman, J.M. (Jodi M.), Tarkin, I. (Ivan), Siska, P. (Peter), Gruen, G. (Gary), Evans, A. (Andrew), Farrell, D.J. (Dana J.), Irrgang, J. (James), Luther, A. (Arlene), Cross, W.W. (William W.), Cass, J.R. (Joseph R.), Sems, S.A. (Stephen A.), Torchia, M.E. (Michael E.), Scrabeck, T. (Tyson), Jenkins, M. (Mark), Dumais, J. (Jules), Romero, A.W. (Amanda W.), Sagebien, C.A. (Carlos A.), Butler, M.S. (Mark S.), Monica, J.T. (James T.), Seuffert, P. (Patricia), Hsu, J.R. (Joseph R.), Stinner, D. (Daniel), Ficke, J. (James), Charlton, M. (Michael), Napierala, M. (Matthew), Fan, M. (Mary), Tannoury, C. (Chadi), Carlisle, H. (Hope), Silva, H. (Heather), Archdeacon, M. (Michael), Finnan, R. (Ryan), Le, T. (Toan), Wyrick, J. (John), Hess, S. (Shelley), Brennan, M.L. (Michael L.), Probe, R. (Robert), Kile, E. (Evelyn), Mills, K. (Kelli), Clipper, L. (Lydia), Yu, M. (Michelle), Erwin, K. (Katie), Horwitz, D. (Daniel), Strohecker, K. (Kent), Swenson, T.K. (Teresa K.), Schmidt, A.H. (Andrew H.), Westberg, J.R. (Jerald R.), Aurang, K. (Kamran), Zohman, G. (Gary), Peterson, B. (Brett), Huff, R.B. (Roger B.), Baele, J. (Joseph), Weber, T. (Timothy), Edison, M. (Matt), McBeth, J.C. (Jessica Cooper), Shively, K. (Karl), Ertl, J.P. (Janos P.), Mullis, B. (Brian), Parr, J.A. (J. Andrew), Worman, R. (Ripley), Frizzell, V. (Valda), Moore, M.M. (Molly M.), DePaolo, C.J. (Charles J.), Alosky, R. (Rachel), Shell, L.E. (Leslie E.), Hampton, L. (Lynne), Shepard, S. (Stephanie), Nanney, T. (Tracy), Cuento, C. (Claudine), Cantu, R.V. (Robert V.), Henderson, E.R. (Eric R.), Eickhoff, L.S. (Linda S.), Hammerberg, E.M. (E. Mark), Stahel, P. (Philip), Hak, D. (David), Mauffrey, C. (Cyril), Henderson, C. (Corey), Gissel, H. (Hannah), Gibula, D. (Douglas), Zamorano, D.P. (David P.), Tynan, M.C. (Martin C.), Pourmand, D. (Deeba), Lawson, D. (Deanna), Crist, B.D. (Brett D.), Murtha, Y.M. (Yvonne M.), Anderson, L.K. (Linda K.), Linehan, C. (Colleen), Pilling, L. (Lindsey), Lewis, C.G. (Courtland G.), Caminiti, S. (Stephanie), Sullivan, R.J. (Raymond J.), Roper, E. (Elizabeth), Obremskey, W. (William), Kregor, P. (Philip), Richards, J.E. (Justin E.), Stringfellow, K. (Kenya), Dohm, M.P. (Michael P.), Zellar, A. (Abby), Segers, M.J.M. (Michiel), Zijl, J.A.C. (Jacco A.C.), Verhoeven, B. (Bart), Smits, A.B. (Anke B.), De Vries, J.P.P.M. (Jean Paul P.M.), Fioole, B. (Bram), Van Der Hoeven, H. (Henk), Theunissen, E.B.M. (Evert B.M.), De Vries Reilingh, T.S. (Tammo S.), Govaert, L. (Lonneke), Wittich, P. (Philippe), De Brauw, M. (Maurits), Wille, J.C. (Jan), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Ritchie, E.D. (Ewan D.), Wessel, R.N. (Ronald N.), Hammacher, E.R. (Eric), Visser, G.A. (Gijs A.), Stockmann, H. (Heyn), Silvis, R. (Rob), Snellen, J.P. (Jaap P.), Rijbroek, B. (Bram), Scheepers, J.J. (Joris J.), Vermeulen, E.G.J. (Erik G.J.), Siroen, M.P.C. (Michiel P.C.), Vuylsteke, R. (Ronald), Brom, H.L.F., Rijna, H., Rijcke, P.A.R. (Piet), Koppert, C.L. (Cees L.), Buijk, S.E. (Steven E.), Groenendijk, R.P.R. (Richard), Dawson, I. (Imro), Tetteroo, G.W.M. (Geert), Bruijninckx, M.M.M. (Milko), Doornebosch, P. (Pascal), Graaf, E.J.R. (Eelco) de, Elst, M. (Maarten) van der, Pol, C. (Carmen) van der, Riet, M. (Martijne) van 't, Karsten, T.M. (Thomas), Vries, M.R. (Mark) de, Stassen, L.P.S. (Laurents P.S.), Schep, N.W.L. (Niels), Ben Schmidt, G. (G.), Hoffman, W.H. (W. H.), Poolman, R.W. (Rudolf), Simons, M.P., Heijden, F.H.W.M. (Frank) van der, Willems, W.J. (Jaap), De Meulemeester, F.R.A.J. (Frank R.A.J.), Hart, C.P. (Cor P.) van der, Turckan, K. (Kahn), Festen, S. (Sebastiaan), Nies, F. (Frank) de, Out, N.J.M. (Nico J.M.), Bosma, J. (Jan), Kampen, A. (A.) van, Biert, J. (Jan), Van Vugt, A.B. (Arie B.), Edwards, M.J.R. (Michael J.R.), Blokhuis, T.J. (Taco J.), Frölke, J.P.M. (Jan Paul), Geeraedts, L.M.G. (Leo M.G.), Gardeniers, J.W.M. (Jean W.M.), Tan, E.C.T.H. (Edward C.T.H.), Poelhekke, L.M.S.J., De Waal Malefijt, M.C. (Maarten C.), Schreurs, B. (Bart), Roukema, G.R. (Gert), Josaputra, H.A. (Hong A.), Keller, P. (Paul), De Rooij, P.D. (Peter D.), Kuiken, H. (Hans), Boxma, H. (Han), Cleffken, B.I. (Berry), Liem, R. (Ronald), Rhemrev, S. (Steven), Bosman, C.H.R. (Coks H.R.), De Mol Van Otterloo, A. (Alexander), Hoogendoorn, J. (Jochem), Vries, A.C. (Alexander) de, Meylaerts, S.A.G. (Sven), Verhofstad, M.H.J. (Michiel), Meijer, J. (Joost), Van Egmond, T. (Teun), Van Der Brand, I. (Igor), Patka, P. (Peter), Eversdijk, M.G. (Martin), Peters, R. (Rolf), Hartog, D. (Dennis) den, Waes, O.J.F. (Oscar) van, Oprel, P.P. (Pim), Vis, H.M. (Harm) van der, Campo, M. (Martin), Verhagen, R. (Ronald), Albers, G.H.R. (G.H. Robert), Zurcher, A.W. (Arthur W.), Simmermacher, R.K.J., Van Mulken, J. (Jeroen), Wessem, K.J.P. van, Van Gaalen, S.M. (Steven M.), Leenen, L.P.H., Bronkhorst, M.W.G.A. (Maarten), Guicherit, O.R. (Onno R.), Goslings, J.C. (Carel), Ponsen, K.J. (Kees-jan), Bhatia, M. (Mahesh), Arora, V. (Vinod), Tyagi, V. (Vivek), Bedi, H. (Harvinder), Carr, A. (Ashley), Curry, H. (Hamish), Chia, A. (Andrew), Csongvay, S. (Steve), Donohue, C. (Craig), Doig, S. (Stephen), Edwards, E. (Elton), Etherington, G. (Greg), Esser, M. (Max), Gong, A. (Andrew), Jain, A. (Arvind), Li, D. (Doug), Miller, R. (Russell), Moaveni, A. (Ash), Russ, M. (Matthias), Ton, L. (Lu), Wang, O. (Otis), Dowrick, A. (Adam), Murdoch, Z. (Zoe), Sage, C. (Claire), Frihagen, F. (Frede), Clarke-Jenssen, J. (John), Hjorthaug, G. (Geir), Ianssen, T. (Torben), Amundsen, A. (Asgeir), Brattgjerd, J.E. (Jan Egil), Borch, T. (Tor), Bøe, B. (Berthe), Flatøy, B. (Bernhard), Hasselund, S. (Sondre), Haug, K.J. (Knut Jørgen), Hemlock, K. (Kim), Hoseth, T.M. (Tor Magne), Jomaas, G. (Geir), Kibsgård, T. (Thomas), Lona, T. (Tarjei), Moatshe, G. (Gilbert), Müller, O. (Oliver), Molund, M. (Marius), Nicolaisen, T. (Tor), Nilsen, F. (Fredrik), Rydinge, J. (Jonas), Smedsrud, M. (Morten), Stødle, A. (Are), Trommer, A. (Axel), Ugland, S. (Stein), Karlsten, A. (Anders), Ekås, G. (Guri), Vesterhus, E.B. (Elise Berg), Brekke, A.C. (Anne Christine), Gupta, A. (Ajay), Jain, N. (Neeraj), Khan, F. (Farah), Sharma, A. (Ateet), Sanghavi, A. (Amir), Trivedi, M. (Mittal), Rai, A. (Anil), Subash, (), Rai, K. (Kamal), Yadav, V. (Vineet), Singh, S. (Sanjay), Tetsworth, K. (Kevin), Donald, G. (Geoff), Weinrauch, P. (Patrick), Pincus, P. (Paul), Yang, S. (Steven), Halliday, B. (Brett), Gervais, T. (Trevor), Holt, M. (Michael), Flynn, A. (Annette), Prasad, A.S. (Amal Shankar), Mishra, V. (Vimlesh), Sundaresh, D.C. (D. C.), Khanna, A. (Angshuman), Cherian, J.J. (Joe Joseph), Olakkengil, D.J. (Davy J), Sharma, G. (Gaurav), Pirpiris, M. (Marinis), Love, D. (David), Bucknill, A. (Andrew), Farrugia, R.J. (Richard J), Pape, H.-C. (Hans-Christoph), Knobe, M. (Matthias), Pfeifer, R. (Roman), Hull, P. (Peter), Lewis, S. (Sophie), Evans, S. (Simone), Nanda, R. (Rajesh), Logishetty, R. (Rajanikanth), Anand, S. (Sanjeev), Bowler, C. (Carol), Dadi, A. (Akhil), Palla, N. (Naveen), Ganguly, U. (Utsav), Rai, B.S. (B. Sachidananda), Rajakumar, J. (Janakiraman), Jennings, A. (Andrew), Chuter, G. (Graham), Rose, G. (Glynis), Horner, G. (Gillian), Clark, C. (Callum), Eke, K. (Kate), Reed, M.R. (Mike), Inman, D. (Dominic), Herriott, C. (Chris), Dobb, C. (Christine), Sprague, S. (Sheila), Schemitsch, E.H. (Emil H.), Swiontkowski, M.F. (Marc ), Della Rocca, G.J. (Gregory J.), Jeray, K.J. (Kyle J.), Liew, S. (Susan), Slobogean, G.P. (Gerard P.), Bzovsky, S. (Sofia), Heels-Ansdell, D. (Diane), Zhou, Q. (Qi), Bhandari, M. (Mohit), Sprag, S. (Sheila), Devereaux, P.J., Guyatt, G.H. (Gordon), Heetveld, M.J. (Martin J.), Richardson, M. (Martin), Thabane, L. (Lehana), Tornetta III, P. (Paul), Walter, S.D. (Stephen D.), McKay, P. (Paula), Scott, T. (Taryn), Garibaldi, A. (Alisha), Viveiros, H. (Helena), Swinton, M. (Marilyn), Gichuru, M. (Mark), Buckingham, L. (Lisa), Duraikannan, A. (Aravin), Maddock, D. (Deborah), Simunovic, N. (Nicole), Agel, J. (Julie), Lieshout, E.M.M. (Esther) van, Zielinski, S.M. (Stephanie), Rangan, A. (Amar), Hanusch, B.C. (Birgit C.), Kottam, L. (Lucksy), Clarkson, R. (Rachel), Haverlag, R. (Robert), McCormack, R. (Robert), Apostle, K. (Kelly), Boyer, D. (Dory), Moola, F. (Farhad), Perey, B. (Bertrand), Stone, T. (Trevor), Viskontas, D. (Darius), Lemke, H.M. (H. Michael), Zomar, M. (Mauri), Moon, K. (Karyn), Moon, R. (Raely), Oatt, A. (Amber), Buckley, R.E. (Richard E.), Duffy, P. (Paul), Korley, R. (Robert), Puloski, S. (Shannon), Powell, J. (James), Johnston, K. (Kelly), Carcary, K. (Kimberly), Lorenzo, M. (Melissa), McKercher, R. (Ross), Sanders, D. (David), MacLeod, M. (Mark), Lawendy, A.-R. (Abdel-Rahman), Tieszer, C. (Christina), Stephen, D. (David), Kreder, H. (Hans), Jenkinson, R. (Richard), Nousiainen, M. (Markku), Axelrod, T. (Terry), Murnaghan, J. (John), Nam, D. (Diane), Wadey, V. (Veronica), Yee, A. (Albert), Milner, K. (Katrine), Kunz, M. (Monica), Ghent, W. (Wesley), McKee, M.D. (Michael D.), Hall, J.A. (Jeremy A.), Nauth, A. (Aaron), Ahn, H. (Henry), Whelan, D.B. (Daniel B.), Vicente, M.R. (Milena R.), Wild, L.M. (Lisa M.), Khan, R.M. (Ryan M.), Hidy, J.T. (Jennifer T.), Coles, C. (Chad), Leighton, R. (Ross), Biddulph, M. (Michael), Johnston, D. (David), Glazebrook, M. (Mark), Alexander, D. (David), Coady, C. (Catherine), Dunbar, M. (Michael), Amirault, J.D. (J. David), Gross, M. (Michael), Oxner, W. (William), Reardon, G. (Gerald), Richardson, C.G. (C. Glen), Trenholm, J.A. (J. Andrew), Wong, I. (Ivan), Trask, K. (Kelly), MacDonald, S. (Shelley), Dobbin, G. (Gwendolyn), Bicknell, R. (Ryan), Yach, J. (Jeff), Bardana, D. (Davide), Wood, G. (Gavin), Harrison, M. (Mark), Yen, D. (David), Lambert, S. (Sue), Howells, F. (Fiona), Ward, A. (Angela), Zalzal, P. (Paul), Brien, H. (Heather), Naumetz, V. (V.), Weening, B. (Brad), Wai, E.K. (Eugene K.), Papp, S. (Steve), Gofton, W.T. (Wade T.), Liew, A. (Allen), Kingwell, S.P. (Stephen P.), Johnson, G. (Garth), O'Neil, J. (Joseph), Roffey, D.M. (Darren M.), Borsella, V. (Vivian), Avram, V. (Victoria), Oliver, T.M. (Todd M.), Jones, V. (Vicki), Vogt, M. (Michelle), Jones, C.B. (Clifford B.), Ringler, J.R. (James R.), Endres, T.J. (Terrence J.), Sietsema, D.L. (Debra L.), Walker, J.E. (Jane E.), Broderick, J.S. (J. Scott), Goetz, D.R. (David R.), Pace, T.B. (Thomas B.), Schaller, T.M. (Thomas M.), Porter, S.E. (Scott E.), Beckish, M.L. (Michael L.), Adams, J.D. (John D.), Barden, B.B. (Benjamin B.), Creek, A.T. (Aaron T.), Finley, S.H. (Stephen H.), Foret, J.L. (Jonathan L.), Gudger, G.K. (Garland K.), Gurich, R.W. (Richard W.), Hill, A.D. (Austin D.), Hollenbeck, S.M. (Steven M.), Jackson, L.T. (Lyle T.), Kruse, K.K. (Kevin K.), Lackey, W.G. (Wesley G.), Langan, J.W. (Justin W.), Lee, J. (Julia), Leffler, L.C. (Lauren C.), Miller, T.J. (Timothy J.), Murphy, R.L. (R. Lee), O'Malley, L.K. (Lawrence K.), Peters, M.E. (Melissa E.), Price, D.M. (Dustin M.), Tanksley, J.A. (John A.), Torres, E.T. (Erick T.), Watson, D.J. (Dylan J.), Watson, S.T. (Scott T.), Tanner, S.L. (Stephanie L.), Snider, R.G. (Rebecca G.), Nastoff, L.A. (Lauren A.), Bielby, S.A. (Shea A.), Teasdall, R.J. (Robert J.), Switzer, J.A. (Julie A.), Cole, P.A. (Peter A.), Anderson, S.A. (Sarah A.), Lafferty, P.M. (Paul M.), Li, M. (Mengnai), Ly, T.V. (Thuan V.), Marston, S.B. (Scott B.), Foley, A.L. (Amy L.), Vang, S. (Sandy), Wright, D.M. (David M.), Marcantonio, A.J. (Andrew J.), Kain, M.S.H. (Michael S.H.), Iorio, R. (Richard), Specht, L.M. (Lawrence M.), Tilzey, J.F. (John F.), Lobo, M.J. (Margaret J.), Garfi, J.S. (John S.), Vallier, H.A. (Heather A.), Dolenc, A. (Andrea), Breslin, M. (Mary), Prayson, M.J. (Michael J.), Laughlin, R. (Richard), Rubino, L.J. (L. Joseph), May, J. (Jedediah), Rieser, G.R. (Geoffrey Ryan), Dulaney-Cripe, L. (Liz), Gayton, C. (Chris), Shaer, J. (James), Schrickel, T. (Tyson), Hileman, B. (Barbara), Gorczyca, J.T. (John T.), Gross, J.M. (Jonathan M.), Humphrey, C.A. (Catherine A.), Kates, S. (Stephen), Ketz, J.P. (John P.), Noble, K. (Krista), McIntyre, A.W. (Allison W.), Pecorella, K. (Kaili), Davis, C.A. (Craig A.), Weinerman, S. (Stuart), Weingarten, P. (Peter), Stull, P. (Philip), Lindenbaum, S. (Stephen), Hewitt, M. (Michael), Schwappach, J. (John), Baker, J.K. (Janell K.), Rutherford, T. (Tori), Newman, H. (Heike), Lieberman, S. (Shane), Finn, E. (Erin), Robbins, K. (Kristin), Hurley, M. (Meghan), Lyle, L. (Lindsey), Mitchell, K. (Khalis), Browner, K. (Kieran), Whatley, E. (Erica), Payton, K. (Krystal), Reeves, C. (Christina), Cannada, L.K. (Lisa K.), Karges, D.E. (David E.), Dawson, S.A. (Sarah A.), Mehta, S. (Samir), Esterhai, J. (John), Ahn, J. (Jaimo), Donegan, D. (Derek), Horan, A.D. (Annamarie D.), Hesketh, P.J. (Patrick J.), Bannister, E.R. (Evan R.), Keeve, J.P. (Jonathan P.), Anderson, C.G. (Christopher G.), McDonald, M.D. (Michael D.), Hoffman, J.M. (Jodi M.), Tarkin, I. (Ivan), Siska, P. (Peter), Gruen, G. (Gary), Evans, A. (Andrew), Farrell, D.J. (Dana J.), Irrgang, J. (James), Luther, A. (Arlene), Cross, W.W. (William W.), Cass, J.R. (Joseph R.), Sems, S.A. (Stephen A.), Torchia, M.E. (Michael E.), Scrabeck, T. (Tyson), Jenkins, M. (Mark), Dumais, J. (Jules), Romero, A.W. (Amanda W.), Sagebien, C.A. (Carlos A.), Butler, M.S. (Mark S.), Monica, J.T. (James T.), Seuffert, P. (Patricia), Hsu, J.R. (Joseph R.), Stinner, D. (Daniel), Ficke, J. (James), Charlton, M. (Michael), Napierala, M. (Matthew), Fan, M. (Mary), Tannoury, C. (Chadi), Carlisle, H. (Hope), Silva, H. (Heather), Archdeacon, M. (Michael), Finnan, R. (Ryan), Le, T. (Toan), Wyrick, J. (John), Hess, S. (Shelley), Brennan, M.L. (Michael L.), Probe, R. (Robert), Kile, E. (Evelyn), Mills, K. (Kelli), Clipper, L. (Lydia), Yu, M. (Michelle), Erwin, K. (Katie), Horwitz, D. (Daniel), Strohecker, K. (Kent), Swenson, T.K. (Teresa K.), Schmidt, A.H. (Andrew H.), Westberg, J.R. (Jerald R.), Aurang, K. (Kamran), Zohman, G. (Gary), Peterson, B. (Brett), Huff, R.B. (Roger B.), Baele, J. (Joseph), Weber, T. (Timothy), Edison, M. (Matt), McBeth, J.C. (Jessica Cooper), Shively, K. (Karl), Ertl, J.P. (Janos P.), Mullis, B. (Brian), Parr, J.A. (J. Andrew), Worman, R. (Ripley), Frizzell, V. (Valda), Moore, M.M. (Molly M.), DePaolo, C.J. (Charles J.), Alosky, R. (Rachel), Shell, L.E. (Leslie E.), Hampton, L. (Lynne), Shepard, S. (Stephanie), Nanney, T. (Tracy), Cuento, C. (Claudine), Cantu, R.V. (Robert V.), Henderson, E.R. (Eric R.), Eickhoff, L.S. (Linda S.), Hammerberg, E.M. (E. Mark), Stahel, P. (Philip), Hak, D. (David), Mauffrey, C. (Cyril), Henderson, C. (Corey), Gissel, H. (Hannah), Gibula, D. (Douglas), Zamorano, D.P. (David P.), Tynan, M.C. (Martin C.), Pourmand, D. (Deeba), Lawson, D. (Deanna), Crist, B.D. (Brett D.), Murtha, Y.M. (Yvonne M.), Anderson, L.K. (Linda K.), Linehan, C. (Colleen), Pilling, L. (Lindsey), Lewis, C.G. (Courtland G.), Caminiti, S. (Stephanie), Sullivan, R.J. (Raymond J.), Roper, E. (Elizabeth), Obremskey, W. (William), Kregor, P. (Philip), Richards, J.E. (Justin E.), Stringfellow, K. (Kenya), Dohm, M.P. (Michael P.), Zellar, A. (Abby), Segers, M.J.M. (Michiel), Zijl, J.A.C. (Jacco A.C.), Verhoeven, B. (Bart), Smits, A.B. (Anke B.), De Vries, J.P.P.M. (Jean Paul P.M.), Fioole, B. (Bram), Van Der Hoeven, H. (Henk), Theunissen, E.B.M. (Evert B.M.), De Vries Reilingh, T.S. (Tammo S.), Govaert, L. (Lonneke), Wittich, P. (Philippe), De Brauw, M. (Maurits), Wille, J.C. (Jan), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Ritchie, E.D. (Ewan D.), Wessel, R.N. (Ronald N.), Hammacher, E.R. (Eric), Visser, G.A. (Gijs A.), Stockmann, H. (Heyn), Silvis, R. (Rob), Snellen, J.P. (Jaap P.), Rijbroek, B. (Bram), Scheepers, J.J. (Joris J.), Vermeulen, E.G.J. (Erik G.J.), Siroen, M.P.C. (Michiel P.C.), Vuylsteke, R. (Ronald), Brom, H.L.F., Rijna, H., Rijcke, P.A.R. (Piet), Koppert, C.L. (Cees L.), Buijk, S.E. (Steven E.), Groenendijk, R.P.R. (Richard), Dawson, I. (Imro), Tetteroo, G.W.M. (Geert), Bruijninckx, M.M.M. (Milko), Doornebosch, P. (Pascal), Graaf, E.J.R. (Eelco) de, Elst, M. (Maarten) van der, Pol, C. (Carmen) van der, Riet, M. (Martijne) van 't, Karsten, T.M. (Thomas), Vries, M.R. (Mark) de, Stassen, L.P.S. (Laurents P.S.), Schep, N.W.L. (Niels), Ben Schmidt, G. (G.), Hoffman, W.H. (W. H.), Poolman, R.W. (Rudolf), Simons, M.P., Heijden, F.H.W.M. (Frank) van der, Willems, W.J. (Jaap), De Meulemeester, F.R.A.J. (Frank R.A.J.), Hart, C.P. (Cor P.) van der, Turckan, K. (Kahn), Festen, S. (Sebastiaan), Nies, F. (Frank) de, Out, N.J.M. (Nico J.M.), Bosma, J. (Jan), Kampen, A. (A.) van, Biert, J. (Jan), Van Vugt, A.B. (Arie B.), Edwards, M.J.R. (Michael J.R.), Blokhuis, T.J. (Taco J.), Frölke, J.P.M. (Jan Paul), Geeraedts, L.M.G. (Leo M.G.), Gardeniers, J.W.M. (Jean W.M.), Tan, E.C.T.H. (Edward C.T.H.), Poelhekke, L.M.S.J., De Waal Malefijt, M.C. (Maarten C.), Schreurs, B. (Bart), Roukema, G.R. (Gert), Josaputra, H.A. (Hong A.), Keller, P. (Paul), De Rooij, P.D. (Peter D.), Kuiken, H. (Hans), Boxma, H. (Han), Cleffken, B.I. (Berry), Liem, R. (Ronald), Rhemrev, S. (Steven), Bosman, C.H.R. (Coks H.R.), De Mol Van Otterloo, A. (Alexander), Hoogendoorn, J. (Jochem), Vries, A.C. (Alexander) de, Meylaerts, S.A.G. (Sven), Verhofstad, M.H.J. (Michiel), Meijer, J. (Joost), Van Egmond, T. (Teun), Van Der Brand, I. (Igor), Patka, P. (Peter), Eversdijk, M.G. (Martin), Peters, R. (Rolf), Hartog, D. (Dennis) den, Waes, O.J.F. (Oscar) van, Oprel, P.P. (Pim), Vis, H.M. (Harm) van der, Campo, M. (Martin), Verhagen, R. (Ronald), Albers, G.H.R. (G.H. Robert), Zurcher, A.W. (Arthur W.), Simmermacher, R.K.J., Van Mulken, J. (Jeroen), Wessem, K.J.P. van, Van Gaalen, S.M. (Steven M.), Leenen, L.P.H., Bronkhorst, M.W.G.A. (Maarten), Guicherit, O.R. (Onno R.), Goslings, J.C. (Carel), Ponsen, K.J. (Kees-jan), Bhatia, M. (Mahesh), Arora, V. (Vinod), Tyagi, V. (Vivek), Bedi, H. (Harvinder), Carr, A. (Ashley), Curry, H. (Hamish), Chia, A. (Andrew), Csongvay, S. (Steve), Donohue, C. (Craig), Doig, S. (Stephen), Edwards, E. (Elton), Etherington, G. (Greg), Esser, M. (Max), Gong, A. (Andrew), Jain, A. (Arvind), Li, D. (Doug), Miller, R. (Russell), Moaveni, A. (Ash), Russ, M. (Matthias), Ton, L. (Lu), Wang, O. (Otis), Dowrick, A. (Adam), Murdoch, Z. (Zoe), Sage, C. (Claire), Frihagen, F. (Frede), Clarke-Jenssen, J. (John), Hjorthaug, G. (Geir), Ianssen, T. (Torben), Amundsen, A. (Asgeir), Brattgjerd, J.E. (Jan Egil), Borch, T. (Tor), Bøe, B. (Berthe), Flatøy, B. (Bernhard), Hasselund, S. (Sondre), Haug, K.J. (Knut Jørgen), Hemlock, K. (Kim), Hoseth, T.M. (Tor Magne), Jomaas, G. (Geir), Kibsgård, T. (Thomas), Lona, T. (Tarjei), Moatshe, G. (Gilbert), Müller, O. (Oliver), Molund, M. (Marius), Nicolaisen, T. (Tor), Nilsen, F. (Fredrik), Rydinge, J. (Jonas), Smedsrud, M. (Morten), Stødle, A. (Are), Trommer, A. (Axel), Ugland, S. (Stein), Karlsten, A. (Anders), Ekås, G. (Guri), Vesterhus, E.B. (Elise Berg), Brekke, A.C. (Anne Christine), Gupta, A. (Ajay), Jain, N. (Neeraj), Khan, F. (Farah), Sharma, A. (Ateet), Sanghavi, A. (Amir), Trivedi, M. (Mittal), Rai, A. (Anil), Subash, (), Rai, K. (Kamal), Yadav, V. (Vineet), Singh, S. (Sanjay), Tetsworth, K. (Kevin), Donald, G. (Geoff), Weinrauch, P. (Patrick), Pincus, P. (Paul), Yang, S. (Steven), Halliday, B. (Brett), Gervais, T. (Trevor), Holt, M. (Michael), Flynn, A. (Annette), Prasad, A.S. (Amal Shankar), Mishra, V. (Vimlesh), Sundaresh, D.C. (D. C.), Khanna, A. (Angshuman), Cherian, J.J. (Joe Joseph), Olakkengil, D.J. (Davy J), Sharma, G. (Gaurav), Pirpiris, M. (Marinis), Love, D. (David), Bucknill, A. (Andrew), Farrugia, R.J. (Richard J), Pape, H.-C. (Hans-Christoph), Knobe, M. (Matthias), Pfeifer, R. (Roman), Hull, P. (Peter), Lewis, S. (Sophie), Evans, S. (Simone), Nanda, R. (Rajesh), Logishetty, R. (Rajanikanth), Anand, S. (Sanjeev), Bowler, C. (Carol), Dadi, A. (Akhil), Palla, N. (Naveen), Ganguly, U. (Utsav), Rai, B.S. (B. Sachidananda), Rajakumar, J. (Janakiraman), Jennings, A. (Andrew), Chuter, G. (Graham), Rose, G. (Glynis), Horner, G. (Gillian), Clark, C. (Callum), Eke, K. (Kate), Reed, M.R. (Mike), Inman, D. (Dominic), Herriott, C. (Chris), and Dobb, C. (Christine)

Abstract

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (for

Published
2018
Full Text
View/download PDF

29. Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial

Author

Nauth, A. (Aaron), Creek, A.T. (Aaron T.), Zellar, A. (Abby), Lawendy, A.-R. (Abdel-Rahman), Dowrick, A. (Adam), Gupta, A. (Ajay), Dadi, A. (Akhil), Kampen, A. (A.) van, Yee, A. (Albert), Vries, A.C. (Alexander) de, de Mol van Otterloo, A. (Alexander), Garibaldi, A. (Alisha), Liew, A. (Allen), McIntyre, A.W. (Allison W.), Prasad, A.S. (Amal Shankar), Romero, A.W. (Amanda W.), Rangan, A. (Amar), Oatt, A. (Amber), Sanghavi, A. (Amir), Foley, A.L. (Amy L.), Karlsten, A. (Anders), Dolenc, A. (Andrea), Bucknill, A. (Andrew), Chia, A. (Andrew), Evans, A. (Andrew), Gong, A. (Andrew), Schmidt, A.H. (Andrew H.), Marcantonio, A.J. (Andrew J.), Jennings, A. (Andrew), Ward, A. (Angela), Khanna, A. (Angshuman), Rai, A. (Anil), Smits, A.B. (Anke B.), Horan, A.D. (Annamarie D.), Brekke, A.C. (Anne Christine), Flynn, A. (Annette), Duraikannan, A. (Aravin), Stødle, A. (Are), van Vugt, A.B. (Arie B.), Luther, A. (Arlene), Zurcher, A.W. (Arthur W.), Jain, A. (Arvind), Amundsen, A. (Asgeir), Moaveni, A. (Ash), Carr, A. (Ashley), Sharma, A. (Ateet), Hill, A.D. (Austin D.), Trommer, A. (Axel), Rai, B.S. (B. Sachidananda), Hileman, B. (Barbara), Schreurs, B. (Bart), Verhoeven, B. (Bart), Barden, B.B. (Benjamin B.), Flatøy, B. (Bernhard), Cleffken, B.I. (Berry), Bøe, B. (Berthe), Perey, B. (Bertrand), Hanusch, B.C. (Birgit C.), Weening, B. (Brad), Fioole, B. (Bram), Rijbroek, B. (Bram), Crist, B.D. (Brett D.), Halliday, B. (Brett), Peterson, B. (Brett), Mullis, B. (Brian), Richardson, C.G. (C. Glen), Clark, C. (Callum), Sagebien, C.A. (Carlos A.), Pol, C. (Carmen) van der, Bowler, C. (Carol), Humphrey, C.A. (Catherine A.), Coady, C. (Catherine), Koppert, C.L. (Cees L.), Coles, C. (Chad), Tannoury, C. (Chadi), DePaolo, C.J. (Charles J.), Gayton, C. (Chris), Herriott, C. (Chris), Reeves, C. (Christina), Tieszer, C. (Christina), Dobb, C. (Christine), Anderson, C.G. (Christopher G.), Sage, C. (Claire), Cuento, C. (Claudine), Jones, C.B. (Clifford B.), Bosman, C.H.R. (Coks H.R.), Linehan, C. (Colleen), Hart, C.P. (Cor P.) van der, Henderson, C. (Corey), Lewis, C.G. (Courtland G.), Davis, C.A. (Craig A.), Donohue, C. (Craig), Mauffrey, C. (Cyril), Sundaresh, D.C. (D. C.), Farrell, D.J. (Dana J.), Whelan, D.B. (Daniel B.), Horwitz, D. (Daniel), Stinner, D. (Daniel), Viskontas, D. (Darius), Roffey, D.M. (Darren M.), Alexander, D. (David), Karges, D.E. (David E.), Hak, D. (David), Johnston, D. (David), Love, D. (David), Wright, D.M. (David M.), Zamorano, D.P. (David P.), Goetz, D.R. (David R.), Sanders, D. (David), Stephen, D. (David), Yen, D. (David), Bardana, D. (Davide), Olakkengil, D.J. (Davy J), Lawson, D. (Deanna), Maddock, D. (Deborah), Sietsema, D.L. (Debra L.), Pourmand, D. (Deeba), Hartog, D. (Dennis) den, Donegan, D. (Derek), Heels-Ansdell, D. (Diane), Nam, D. (Diane), Inman, D. (Dominic), Boyer, D. (Dory), Li, D. (Doug), Gibula, D. (Douglas), Price, D.M. (Dustin M.), Watson, D.J. (Dylan J.), Hammerberg, E.M. (E. Mark), Tan, E.T.C.H. (Edward T.C.H.), Graaf, E.J.R. (Eelco) de, Vesterhus, E.B. (Elise Berg), Roper, E. (Elizabeth), Edwards, E. (Elton), Schemitsch, E.H. (Emil), Hammacher, E.R. (Eric), Henderson, E.R. (Eric R.), Whatley, E. (Erica), Torres, E.T. (Erick T.), Vermeulen, E.G.J. (Erik G.J.), Finn, E. (Erin), Lieshout, E.M.M. (Esther) van, Wai, E.K. (Eugene K.), Bannister, E.R. (Evan R.), Kile, E. (Evelyn), Theunissen, E.B.M. (Evert B.M.), Ritchie, E.D. (Ewan D.), Khan, F. (Farah), Moola, F. (Farhad), Howells, F. (Fiona), Nies, F. (Frank) de, Heijden, F.H.W.M. (Frank) van der, de Meulemeester, F.R.A.J. (Frank R.A.J.), Frihagen, F. (Frede), Nilsen, F. (Fredrik), Schmidt, G.B. (G. Ben), Albers, G.H.R. (G.H. Robert), Gudger, G.K. (Garland K.), Johnson, G. (Garth), Gruen, G. (Gary), Zohman, G. (Gary), Sharma, G. (Gaurav), Wood, G. (Gavin), Tetteroo, G.W.M. (Geert), Hjorthaug, G. (Geir), Jomaas, G. (Geir), Donald, G. (Geoff), Rieser, G.R. (Geoffrey Ryan), Reardon, G. (Gerald), Slobogean, G.P. (Gerard P.), Roukema, G.R. (Gert), Visser, G.A. (Gijs A.), Moatshe, G. (Gilbert), Horner, G. (Gillian), Rose, G. (Glynis), Guyatt, G. (Gordon), Chuter, G. (Graham), Etherington, G. (Greg), Rocca, G.J.D. (Gregory J. Della), Ekås, G. (Guri), Dobbin, G. (Gwendolyn), Lemke, H.M. (H. Michael), Curry, H. (Hamish), Boxma, H. (Han), Gissel, H. (Hannah), Kreder, H. (Hans), Kuiken, H. (Hans), Brom, H.L.F., Pape, H.-C. (Hans-Christoph), Vis, H.M. (Harm) van der, Bedi, H. (Harvinder), Vallier, H.A. (Heather A.), Brien, H. (Heather), Silva, H. (Heather), Newman, H. (Heike), Viveiros, H. (Helena), van der Hoeven, H. (Henk), Ahn, H. (Henry), Johal, H. (Herman), Rijna, H., Stockmann, H. (Heyn), Josaputra, H.A. (Hong A.), Carlisle, H. (Hope), van der Brand, I. (Igor), Dawson, I. (Imro), Tarkin, I. (Ivan), Wong, I. (Ivan), Parr, J.A. (J. Andrew), Trenholm, J.A. (J. Andrew), Goslings, J.C. (Carel), Amirault, J.D. (J. David), Broderick, J.S. (J. Scott), Snellen, J.P. (Jaap P.), Zijl, J.A.C. (Jacco A.C.), Ahn, J. (Jaimo), Ficke, J. (James), Irrgang, J. (James), Powell, J. (James), Ringler, J.R. (James R.), Shaer, J. (James), Monica, J.T. (James T.), Biert, J. (Jan), Bosma, J. (Jan), Brattgjerd, J.E. (Jan Egil), Frölke, J.P.M. (Jan Paul), Wille, J.C. (Jan), Rajakumar, J. (Janakiraman), Walker, J.E. (Jane E.), Baker, J.K. (Janell K.), Ertl, J.P. (Janos P.), de Vries, J.P.P.M. (Jean Paul P.M.), Gardeniers, J.W.M. (Jean W.M.), May, J. (Jedediah), Yach, J. (Jeff), Hidy, J.T. (Jennifer T.), Westberg, J.R. (Jerald R.), Hall, J.A. (Jeremy A.), van Mulken, J. (Jeroen), McBeth, J.C. (Jessica Cooper), Hoogendoorn, J. (Jochem), Hoffman, J.M. (Jodi M.), Cherian, J.J. (Joe Joseph), Tanksley, J.A. (John A.), Clarke-Jenssen, J. (John), Adams, J.D. (John D.), Esterhai, J. (John), Tilzey, J.F. (John F.), Murnaghan, J. (John), Ketz, J.P. (John P.), Garfi, J.S. (John S.), Schwappach, J. (John), Gorczyca, J.T. (John T.), Wyrick, J. (John), Rydinge, J. (Jonas), Foret, J.L. (Jonathan L.), Gross, J.M. (Jonathan M.), Keeve, J.P. (Jonathan P.), Meijer, J. (Joost), Scheepers, J.J. (Joris J.), Baele, J. (Joseph), O'Neil, J. (Joseph), Cass, J.R. (Joseph R.), Hsu, J.R. (Joseph R.), Dumais, J. (Jules), Lee, J. (Julia), Switzer, J.A. (Julie A.), Agel, J. (Julie), Richards, J.E. (Justin E.), Langan, J.W. (Justin W.), Turckan, K. (Kahn), Pecorella, K. (Kaili), Rai, K. (Kamal), Aurang, K. (Kamran), Shively, K. (Karl), Wessem, K.J.P. van, Moon, K. (Karyn), Eke, K. (Kate), Erwin, K. (Katie), Milner, K. (Katrine), Ponsen, K.J. (Kees-jan), Mills, K. (Kelli), Apostle, K. (Kelly), Johnston, K. (Kelly), Trask, K. (Kelly), Strohecker, K. (Kent), Stringfellow, K. (Kenya), Kruse, K.K. (Kevin K.), Tetsworth, K. (Kevin), Mitchell, K. (Khalis), Browner, K. (Kieran), Hemlock, K. (Kim), Carcary, K. (Kimberly), Jørgen Haug, K. (Knut), Noble, K. (Krista), Robbins, K. (Kristin), Payton, K. (Krystal), Jeray, K.J. (Kyle J.), Rubino, L.J. (L. Joseph), Nastoff, L.A. (Lauren A.), Leffler, L.C. (Lauren C.), Stassen, L.P. (Laurents), O'Malley, L.K. (Lawrence K.), Specht, L.M. (Lawrence M.), Thabane, L. (Lehana), Geeraedts, L.M.G. (Leo M.G.), Shell, L.E. (Leslie E.), Anderson, L.K. (Linda K.), Eickhoff, L.S. (Linda S.), Lyle, L. (Lindsey), Pilling, L. (Lindsey), Buckingham, L. (Lisa), Cannada, L.K. (Lisa K.), Wild, L.M. (Lisa M.), Dulaney-Cripe, L. (Liz), Poelhekke, L.M.S.J., Govaert, L. (Lonneke), Ton, L. (Lu), Kottam, L. (Lucksy), Leenen, L.P.H. (Luke), Clipper, L. (Lydia), Jackson, L.T. (Lyle T.), Hampton, L. (Lynne), de Waal Malefijt, M.C. (Maarten C.), Simons, M.P., Elst, M. (Maarten) van der, Bronkhorst, M.W.G.A. (Maarten), Bhatia, M. (Mahesh), Swiontkowski, M.F. (Marc ), Lobo, M.J. (Margaret J.), Swinton, M. (Marilyn), Pirpiris, M. (Marinis), Molund, M. (Marius), Gichuru, M. (Mark), Glazebrook, M. (Mark), Harrison, M. (Mark), Jenkins, M. (Mark), MacLeod, M. (Mark), Vries, M.R. (Mark) de, Butler, M.S. (Mark S.), Nousiainen, M. (Markku), van ‘t Riet, M. (Martijne), Tynan, M.C. (Martin C.), Campo, M. (Martin), Eversdijk, M.G. (Martin), Heetveld, M.J. (Martin), Richardson, M. (Martin), Breslin, M. (Mary), Fan, M. (Mary), Edison, M. (Matt), Napierala, M. (Matthew), Knobe, M. (Matthias), Russ, M. (Matthias), Zomar, M. (Mauri), de Brauw, M. (Maurits), Esser, M. (Max), Hurley, M. (Meghan), Peters, M.E. (Melissa E.), Lorenzo, M. (Melissa), Li, M. (Mengnai), Archdeacon, M. (Michael), Biddulph, M. (Michael), Charlton, M. (Michael), McDonald, M.D. (Michael D.), McKee, M.D. (Michael D.), Dunbar, M. (Michael), Torchia, M.E. (Michael E.), Gross, M. (Michael), Hewitt, M. (Michael), Holt, M. (Michael), Prayson, M.J. (Michael J.), Edwards, M.J.R. (Michael), Beckish, M.L. (Michael L.), Brennan, M.L. (Michael L.), Dohm, M.P. (Michael P.), Kain, M.S.H. (Michael S.H.), Vogt, M. (Michelle), Yu, M. (Michelle), Verhofstad, M.H.J. (Michiel), Segers, M.J.M. (Michiel J.M.), Segers, M.J.M. (Michiel), Siroen, M.P.C. (Michiel P.C.), Reed, M.R. (Mike), Vicente, M.R. (Milena R.), Bruijninckx, M.M.M. (Milko), Trivedi, M. (Mittal), Bhandari, M. (Mohit), Moore, M.M. (Molly M.), Kunz, M. (Monica), Smedsrud, M. (Morten), Palla, N. (Naveen), Jain, N. (Neeraj), Out, N.J.M. (Nico J.M.), Simunovic, N. (Nicole), Schep, N.W.L. (Niels), Müller, O. (Oliver), Guicherit, O.R. (Onno R.), Waes, O.J.F. (Oscar) van, Wang, O. (Otis), Doornebosch, P. (Pascal), Seuffert, P. (Patricia), Hesketh, P.J. (Patrick J.), Weinrauch, P. (Patrick), Duffy, P. (Paul), Keller, P. (Paul), Lafferty, P.M. (Paul M.), Pincus, P. (Paul), Tornetta III, P. (Paul), Zalzal, P. (Paul), McKay, P. (Paula), Cole, P.A. (Peter A.), de Rooij, P.D. (Peter D.), Hull, P. (Peter), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Patka, P. (Peter), Siska, P. (Peter), Weingarten, P. (Peter), Kregor, P. (Philip), Stahel, P. (Philip), Stull, P. (Philip), Wittich, P. (Philippe), Rijcke, P.A.R. (Piet), Oprel, P.P. (Pim), Devereaux, P.J. (P. J.), Zhou, Q. (Qi), Lee Murphy, R. (R.), Alosky, R. (Rachel), Clarkson, R. (Rachel), Moon, R. (Raely), Logishetty, R. (Rajanikanth), Nanda, R. (Rajesh), Sullivan, R.J. (Raymond J.), Snider, R.G. (Rebecca G.), Buckley, R.E. (Richard E.), Iorio, R. (Richard), Farrugia, R.J. (Richard J), Jenkinson, R. (Richard), Laughlin, R. (Richard), Groenendijk, R.P.R. (Richard), Gurich, R.W. (Richard W.), Worman, R. (Ripley), Silvis, R. (Rob), Haverlag, R. (Robert), Teasdall, R.J. (Robert J.), Korley, R. (Robert), McCormack, R. (Robert), Probe, R. (Robert), Cantu, R.V. (Robert V.), Huff, R.B. (Roger B.), Simmermacher, R.K.J., Peters, R. (Rolf), Pfeifer, R. (Roman), Liem, R. (Ronald), Wessel, R.N. (Ronald N.), Verhagen, R. (Ronald), Vuylsteke, R. (Ronald), Leighton, R. (Ross), McKercher, R. (Ross), Poolman, R.W. (Rudolf), Miller, R. (Russell), Bicknell, R. (Ryan), Finnan, R. (Ryan), Khan, R.M. (Ryan M.), Mehta, S. (Samir), Vang, S. (Sandy), Singh, S. (Sanjay), Anand, S. (Sanjeev), Anderson, S.A. (Sarah A.), Dawson, S.A. (Sarah A.), Marston, S.B. (Scott B.), Porter, S.E. (Scott E.), Watson, S.T. (Scott T.), Festen, S. (Sebastiaan), Lieberman, S. (Shane), Puloski, S. (Shannon), Bielby, S.A. (Shea A.), Sprague, S. (Sheila), Hess, S. (Shelley), MacDonald, S. (Shelley), Evans, S. (Simone), Bzovsky, S. (Sofia), Hasselund, S. (Sondre), Lewis, S. (Sophie), Ugland, S. (Stein), Caminiti, S. (Stephanie), Tanner, S.L. (Stephanie L.), Zielinski, S.M. (Stephanie), Shepard, S. (Stephanie), Sems, S.A. (Stephen A.), Walter, S.D. (Stephen D.), Doig, S. (Stephen), Finley, S.H. (Stephen H.), Kates, S. (Stephen), Lindenbaum, S. (Stephen), Kingwell, S.P. (Stephen P.), Csongvay, S. (Steve), Papp, S. (Steve), Buijk, S.E. (Steven E.), Rhemrev, S. (Steven), Hollenbeck, S.M. (Steven M.), van Gaalen, S.M. (Steven M.), Yang, S. (Steven), Weinerman, S. (Stuart), Subash, (), Lambert, S. (Sue), Liew, S. (Susan), Meylaerts, S.A.G. (Sven), Blokhuis, T.J. (Taco J.), de Vries Reilingh, T.S. (Tammo S.), Lona, T. (Tarjei), Scott, T. (Taryn), Swenson, T.K. (Teresa K.), Endres, T.J. (Terrence J.), Axelrod, T. (Terry), van Egmond, T. (Teun), Pace, T.B. (Thomas B.), Kibsgård, T. (Thomas), Schaller, T.M. (Thomas M.), Ly, T.V. (Thuan V.), Miller, T.J. (Timothy J.), Weber, T. (Timothy), Le, T. (Toan), Oliver, T.M. (Todd M.), Karsten, T.M. (Thomas), Borch, T. (Tor), Hoseth, T.M. (Tor Magne), Nicolaisen, T. (Tor), Ianssen, T. (Torben), Rutherford, T. (Tori), Nanney, T. (Tracy), Gervais, T. (Trevor), Stone, T. (Trevor), Schrickel, T. (Tyson), Scrabeck, T. (Tyson), Ganguly, U. (Utsav), Naumetz, V. (V.), Frizzell, V. (Valda), Wadey, V. (Veronica), Jones, V. (Vicki), Avram, V. (Victoria), Mishra, V. (Vimlesh), Yadav, V. (Vineet), Arora, V. (Vinod), Tyagi, V. (Vivek), Borsella, V. (Vivian), Willems, W.J. (Jaap), Hoffman, W.H. (W. H.), Gofton, W.T. (Wade T.), Lackey, W.G. (Wesley G.), Ghent, W. (Wesley), Obremskey, W. (William), Oxner, W. (William), Cross, W.W. (William W.), Murtha, Y.M. (Yvonne M.), Murdoch, Z. (Zoe), Nauth, A. (Aaron), Creek, A.T. (Aaron T.), Zellar, A. (Abby), Lawendy, A.-R. (Abdel-Rahman), Dowrick, A. (Adam), Gupta, A. (Ajay), Dadi, A. (Akhil), Kampen, A. (A.) van, Yee, A. (Albert), Vries, A.C. (Alexander) de, de Mol van Otterloo, A. (Alexander), Garibaldi, A. (Alisha), Liew, A. (Allen), McIntyre, A.W. (Allison W.), Prasad, A.S. (Amal Shankar), Romero, A.W. (Amanda W.), Rangan, A. (Amar), Oatt, A. (Amber), Sanghavi, A. (Amir), Foley, A.L. (Amy L.), Karlsten, A. (Anders), Dolenc, A. (Andrea), Bucknill, A. (Andrew), Chia, A. (Andrew), Evans, A. (Andrew), Gong, A. (Andrew), Schmidt, A.H. (Andrew H.), Marcantonio, A.J. (Andrew J.), Jennings, A. (Andrew), Ward, A. (Angela), Khanna, A. (Angshuman), Rai, A. (Anil), Smits, A.B. (Anke B.), Horan, A.D. (Annamarie D.), Brekke, A.C. (Anne Christine), Flynn, A. (Annette), Duraikannan, A. (Aravin), Stødle, A. (Are), van Vugt, A.B. (Arie B.), Luther, A. (Arlene), Zurcher, A.W. (Arthur W.), Jain, A. (Arvind), Amundsen, A. (Asgeir), Moaveni, A. (Ash), Carr, A. (Ashley), Sharma, A. (Ateet), Hill, A.D. (Austin D.), Trommer, A. (Axel), Rai, B.S. (B. Sachidananda), Hileman, B. (Barbara), Schreurs, B. (Bart), Verhoeven, B. (Bart), Barden, B.B. (Benjamin B.), Flatøy, B. (Bernhard), Cleffken, B.I. (Berry), Bøe, B. (Berthe), Perey, B. (Bertrand), Hanusch, B.C. (Birgit C.), Weening, B. (Brad), Fioole, B. (Bram), Rijbroek, B. (Bram), Crist, B.D. (Brett D.), Halliday, B. (Brett), Peterson, B. (Brett), Mullis, B. (Brian), Richardson, C.G. (C. Glen), Clark, C. (Callum), Sagebien, C.A. (Carlos A.), Pol, C. (Carmen) van der, Bowler, C. (Carol), Humphrey, C.A. (Catherine A.), Coady, C. (Catherine), Koppert, C.L. (Cees L.), Coles, C. (Chad), Tannoury, C. (Chadi), DePaolo, C.J. (Charles J.), Gayton, C. (Chris), Herriott, C. (Chris), Reeves, C. (Christina), Tieszer, C. (Christina), Dobb, C. (Christine), Anderson, C.G. (Christopher G.), Sage, C. (Claire), Cuento, C. (Claudine), Jones, C.B. (Clifford B.), Bosman, C.H.R. (Coks H.R.), Linehan, C. (Colleen), Hart, C.P. (Cor P.) van der, Henderson, C. (Corey), Lewis, C.G. (Courtland G.), Davis, C.A. (Craig A.), Donohue, C. (Craig), Mauffrey, C. (Cyril), Sundaresh, D.C. (D. C.), Farrell, D.J. (Dana J.), Whelan, D.B. (Daniel B.), Horwitz, D. (Daniel), Stinner, D. (Daniel), Viskontas, D. (Darius), Roffey, D.M. (Darren M.), Alexander, D. (David), Karges, D.E. (David E.), Hak, D. (David), Johnston, D. (David), Love, D. (David), Wright, D.M. (David M.), Zamorano, D.P. (David P.), Goetz, D.R. (David R.), Sanders, D. (David), Stephen, D. (David), Yen, D. (David), Bardana, D. (Davide), Olakkengil, D.J. (Davy J), Lawson, D. (Deanna), Maddock, D. (Deborah), Sietsema, D.L. (Debra L.), Pourmand, D. (Deeba), Hartog, D. (Dennis) den, Donegan, D. (Derek), Heels-Ansdell, D. (Diane), Nam, D. (Diane), Inman, D. (Dominic), Boyer, D. (Dory), Li, D. (Doug), Gibula, D. (Douglas), Price, D.M. (Dustin M.), Watson, D.J. (Dylan J.), Hammerberg, E.M. (E. Mark), Tan, E.T.C.H. (Edward T.C.H.), Graaf, E.J.R. (Eelco) de, Vesterhus, E.B. (Elise Berg), Roper, E. (Elizabeth), Edwards, E. (Elton), Schemitsch, E.H. (Emil), Hammacher, E.R. (Eric), Henderson, E.R. (Eric R.), Whatley, E. (Erica), Torres, E.T. (Erick T.), Vermeulen, E.G.J. (Erik G.J.), Finn, E. (Erin), Lieshout, E.M.M. (Esther) van, Wai, E.K. (Eugene K.), Bannister, E.R. (Evan R.), Kile, E. (Evelyn), Theunissen, E.B.M. (Evert B.M.), Ritchie, E.D. (Ewan D.), Khan, F. (Farah), Moola, F. (Farhad), Howells, F. (Fiona), Nies, F. (Frank) de, Heijden, F.H.W.M. (Frank) van der, de Meulemeester, F.R.A.J. (Frank R.A.J.), Frihagen, F. (Frede), Nilsen, F. (Fredrik), Schmidt, G.B. (G. Ben), Albers, G.H.R. (G.H. Robert), Gudger, G.K. (Garland K.), Johnson, G. (Garth), Gruen, G. (Gary), Zohman, G. (Gary), Sharma, G. (Gaurav), Wood, G. (Gavin), Tetteroo, G.W.M. (Geert), Hjorthaug, G. (Geir), Jomaas, G. (Geir), Donald, G. (Geoff), Rieser, G.R. (Geoffrey Ryan), Reardon, G. (Gerald), Slobogean, G.P. (Gerard P.), Roukema, G.R. (Gert), Visser, G.A. (Gijs A.), Moatshe, G. (Gilbert), Horner, G. (Gillian), Rose, G. (Glynis), Guyatt, G. (Gordon), Chuter, G. (Graham), Etherington, G. (Greg), Rocca, G.J.D. (Gregory J. Della), Ekås, G. (Guri), Dobbin, G. (Gwendolyn), Lemke, H.M. (H. Michael), Curry, H. (Hamish), Boxma, H. (Han), Gissel, H. (Hannah), Kreder, H. (Hans), Kuiken, H. (Hans), Brom, H.L.F., Pape, H.-C. (Hans-Christoph), Vis, H.M. (Harm) van der, Bedi, H. (Harvinder), Vallier, H.A. (Heather A.), Brien, H. (Heather), Silva, H. (Heather), Newman, H. (Heike), Viveiros, H. (Helena), van der Hoeven, H. (Henk), Ahn, H. (Henry), Johal, H. (Herman), Rijna, H., Stockmann, H. (Heyn), Josaputra, H.A. (Hong A.), Carlisle, H. (Hope), van der Brand, I. (Igor), Dawson, I. (Imro), Tarkin, I. (Ivan), Wong, I. (Ivan), Parr, J.A. (J. Andrew), Trenholm, J.A. (J. Andrew), Goslings, J.C. (Carel), Amirault, J.D. (J. David), Broderick, J.S. (J. Scott), Snellen, J.P. (Jaap P.), Zijl, J.A.C. (Jacco A.C.), Ahn, J. (Jaimo), Ficke, J. (James), Irrgang, J. (James), Powell, J. (James), Ringler, J.R. (James R.), Shaer, J. (James), Monica, J.T. (James T.), Biert, J. (Jan), Bosma, J. (Jan), Brattgjerd, J.E. (Jan Egil), Frölke, J.P.M. (Jan Paul), Wille, J.C. (Jan), Rajakumar, J. (Janakiraman), Walker, J.E. (Jane E.), Baker, J.K. (Janell K.), Ertl, J.P. (Janos P.), de Vries, J.P.P.M. (Jean Paul P.M.), Gardeniers, J.W.M. (Jean W.M.), May, J. (Jedediah), Yach, J. (Jeff), Hidy, J.T. (Jennifer T.), Westberg, J.R. (Jerald R.), Hall, J.A. (Jeremy A.), van Mulken, J. (Jeroen), McBeth, J.C. (Jessica Cooper), Hoogendoorn, J. (Jochem), Hoffman, J.M. (Jodi M.), Cherian, J.J. (Joe Joseph), Tanksley, J.A. (John A.), Clarke-Jenssen, J. (John), Adams, J.D. (John D.), Esterhai, J. (John), Tilzey, J.F. (John F.), Murnaghan, J. (John), Ketz, J.P. (John P.), Garfi, J.S. (John S.), Schwappach, J. (John), Gorczyca, J.T. (John T.), Wyrick, J. (John), Rydinge, J. (Jonas), Foret, J.L. (Jonathan L.), Gross, J.M. (Jonathan M.), Keeve, J.P. (Jonathan P.), Meijer, J. (Joost), Scheepers, J.J. (Joris J.), Baele, J. (Joseph), O'Neil, J. (Joseph), Cass, J.R. (Joseph R.), Hsu, J.R. (Joseph R.), Dumais, J. (Jules), Lee, J. (Julia), Switzer, J.A. (Julie A.), Agel, J. (Julie), Richards, J.E. (Justin E.), Langan, J.W. (Justin W.), Turckan, K. (Kahn), Pecorella, K. (Kaili), Rai, K. (Kamal), Aurang, K. (Kamran), Shively, K. (Karl), Wessem, K.J.P. van, Moon, K. (Karyn), Eke, K. (Kate), Erwin, K. (Katie), Milner, K. (Katrine), Ponsen, K.J. (Kees-jan), Mills, K. (Kelli), Apostle, K. (Kelly), Johnston, K. (Kelly), Trask, K. (Kelly), Strohecker, K. (Kent), Stringfellow, K. (Kenya), Kruse, K.K. (Kevin K.), Tetsworth, K. (Kevin), Mitchell, K. (Khalis), Browner, K. (Kieran), Hemlock, K. (Kim), Carcary, K. (Kimberly), Jørgen Haug, K. (Knut), Noble, K. (Krista), Robbins, K. (Kristin), Payton, K. (Krystal), Jeray, K.J. (Kyle J.), Rubino, L.J. (L. Joseph), Nastoff, L.A. (Lauren A.), Leffler, L.C. (Lauren C.), Stassen, L.P. (Laurents), O'Malley, L.K. (Lawrence K.), Specht, L.M. (Lawrence M.), Thabane, L. (Lehana), Geeraedts, L.M.G. (Leo M.G.), Shell, L.E. (Leslie E.), Anderson, L.K. (Linda K.), Eickhoff, L.S. (Linda S.), Lyle, L. (Lindsey), Pilling, L. (Lindsey), Buckingham, L. (Lisa), Cannada, L.K. (Lisa K.), Wild, L.M. (Lisa M.), Dulaney-Cripe, L. (Liz), Poelhekke, L.M.S.J., Govaert, L. (Lonneke), Ton, L. (Lu), Kottam, L. (Lucksy), Leenen, L.P.H. (Luke), Clipper, L. (Lydia), Jackson, L.T. (Lyle T.), Hampton, L. (Lynne), de Waal Malefijt, M.C. (Maarten C.), Simons, M.P., Elst, M. (Maarten) van der, Bronkhorst, M.W.G.A. (Maarten), Bhatia, M. (Mahesh), Swiontkowski, M.F. (Marc ), Lobo, M.J. (Margaret J.), Swinton, M. (Marilyn), Pirpiris, M. (Marinis), Molund, M. (Marius), Gichuru, M. (Mark), Glazebrook, M. (Mark), Harrison, M. (Mark), Jenkins, M. (Mark), MacLeod, M. (Mark), Vries, M.R. (Mark) de, Butler, M.S. (Mark S.), Nousiainen, M. (Markku), van ‘t Riet, M. (Martijne), Tynan, M.C. (Martin C.), Campo, M. (Martin), Eversdijk, M.G. (Martin), Heetveld, M.J. (Martin), Richardson, M. (Martin), Breslin, M. (Mary), Fan, M. (Mary), Edison, M. (Matt), Napierala, M. (Matthew), Knobe, M. (Matthias), Russ, M. (Matthias), Zomar, M. (Mauri), de Brauw, M. (Maurits), Esser, M. (Max), Hurley, M. (Meghan), Peters, M.E. (Melissa E.), Lorenzo, M. (Melissa), Li, M. (Mengnai), Archdeacon, M. (Michael), Biddulph, M. (Michael), Charlton, M. (Michael), McDonald, M.D. (Michael D.), McKee, M.D. (Michael D.), Dunbar, M. (Michael), Torchia, M.E. (Michael E.), Gross, M. (Michael), Hewitt, M. (Michael), Holt, M. (Michael), Prayson, M.J. (Michael J.), Edwards, M.J.R. (Michael), Beckish, M.L. (Michael L.), Brennan, M.L. (Michael L.), Dohm, M.P. (Michael P.), Kain, M.S.H. (Michael S.H.), Vogt, M. (Michelle), Yu, M. (Michelle), Verhofstad, M.H.J. (Michiel), Segers, M.J.M. (Michiel J.M.), Segers, M.J.M. (Michiel), Siroen, M.P.C. (Michiel P.C.), Reed, M.R. (Mike), Vicente, M.R. (Milena R.), Bruijninckx, M.M.M. (Milko), Trivedi, M. (Mittal), Bhandari, M. (Mohit), Moore, M.M. (Molly M.), Kunz, M. (Monica), Smedsrud, M. (Morten), Palla, N. (Naveen), Jain, N. (Neeraj), Out, N.J.M. (Nico J.M.), Simunovic, N. (Nicole), Schep, N.W.L. (Niels), Müller, O. (Oliver), Guicherit, O.R. (Onno R.), Waes, O.J.F. (Oscar) van, Wang, O. (Otis), Doornebosch, P. (Pascal), Seuffert, P. (Patricia), Hesketh, P.J. (Patrick J.), Weinrauch, P. (Patrick), Duffy, P. (Paul), Keller, P. (Paul), Lafferty, P.M. (Paul M.), Pincus, P. (Paul), Tornetta III, P. (Paul), Zalzal, P. (Paul), McKay, P. (Paula), Cole, P.A. (Peter A.), de Rooij, P.D. (Peter D.), Hull, P. (Peter), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Patka, P. (Peter), Siska, P. (Peter), Weingarten, P. (Peter), Kregor, P. (Philip), Stahel, P. (Philip), Stull, P. (Philip), Wittich, P. (Philippe), Rijcke, P.A.R. (Piet), Oprel, P.P. (Pim), Devereaux, P.J. (P. J.), Zhou, Q. (Qi), Lee Murphy, R. (R.), Alosky, R. (Rachel), Clarkson, R. (Rachel), Moon, R. (Raely), Logishetty, R. (Rajanikanth), Nanda, R. (Rajesh), Sullivan, R.J. (Raymond J.), Snider, R.G. (Rebecca G.), Buckley, R.E. (Richard E.), Iorio, R. (Richard), Farrugia, R.J. (Richard J), Jenkinson, R. (Richard), Laughlin, R. (Richard), Groenendijk, R.P.R. (Richard), Gurich, R.W. (Richard W.), Worman, R. (Ripley), Silvis, R. (Rob), Haverlag, R. (Robert), Teasdall, R.J. (Robert J.), Korley, R. (Robert), McCormack, R. (Robert), Probe, R. (Robert), Cantu, R.V. (Robert V.), Huff, R.B. (Roger B.), Simmermacher, R.K.J., Peters, R. (Rolf), Pfeifer, R. (Roman), Liem, R. (Ronald), Wessel, R.N. (Ronald N.), Verhagen, R. (Ronald), Vuylsteke, R. (Ronald), Leighton, R. (Ross), McKercher, R. (Ross), Poolman, R.W. (Rudolf), Miller, R. (Russell), Bicknell, R. (Ryan), Finnan, R. (Ryan), Khan, R.M. (Ryan M.), Mehta, S. (Samir), Vang, S. (Sandy), Singh, S. (Sanjay), Anand, S. (Sanjeev), Anderson, S.A. (Sarah A.), Dawson, S.A. (Sarah A.), Marston, S.B. (Scott B.), Porter, S.E. (Scott E.), Watson, S.T. (Scott T.), Festen, S. (Sebastiaan), Lieberman, S. (Shane), Puloski, S. (Shannon), Bielby, S.A. (Shea A.), Sprague, S. (Sheila), Hess, S. (Shelley), MacDonald, S. (Shelley), Evans, S. (Simone), Bzovsky, S. (Sofia), Hasselund, S. (Sondre), Lewis, S. (Sophie), Ugland, S. (Stein), Caminiti, S. (Stephanie), Tanner, S.L. (Stephanie L.), Zielinski, S.M. (Stephanie), Shepard, S. (Stephanie), Sems, S.A. (Stephen A.), Walter, S.D. (Stephen D.), Doig, S. (Stephen), Finley, S.H. (Stephen H.), Kates, S. (Stephen), Lindenbaum, S. (Stephen), Kingwell, S.P. (Stephen P.), Csongvay, S. (Steve), Papp, S. (Steve), Buijk, S.E. (Steven E.), Rhemrev, S. (Steven), Hollenbeck, S.M. (Steven M.), van Gaalen, S.M. (Steven M.), Yang, S. (Steven), Weinerman, S. (Stuart), Subash, (), Lambert, S. (Sue), Liew, S. (Susan), Meylaerts, S.A.G. (Sven), Blokhuis, T.J. (Taco J.), de Vries Reilingh, T.S. (Tammo S.), Lona, T. (Tarjei), Scott, T. (Taryn), Swenson, T.K. (Teresa K.), Endres, T.J. (Terrence J.), Axelrod, T. (Terry), van Egmond, T. (Teun), Pace, T.B. (Thomas B.), Kibsgård, T. (Thomas), Schaller, T.M. (Thomas M.), Ly, T.V. (Thuan V.), Miller, T.J. (Timothy J.), Weber, T. (Timothy), Le, T. (Toan), Oliver, T.M. (Todd M.), Karsten, T.M. (Thomas), Borch, T. (Tor), Hoseth, T.M. (Tor Magne), Nicolaisen, T. (Tor), Ianssen, T. (Torben), Rutherford, T. (Tori), Nanney, T. (Tracy), Gervais, T. (Trevor), Stone, T. (Trevor), Schrickel, T. (Tyson), Scrabeck, T. (Tyson), Ganguly, U. (Utsav), Naumetz, V. (V.), Frizzell, V. (Valda), Wadey, V. (Veronica), Jones, V. (Vicki), Avram, V. (Victoria), Mishra, V. (Vimlesh), Yadav, V. (Vineet), Arora, V. (Vinod), Tyagi, V. (Vivek), Borsella, V. (Vivian), Willems, W.J. (Jaap), Hoffman, W.H. (W. H.), Gofton, W.T. (Wade T.), Lackey, W.G. (Wesley G.), Ghent, W. (Wesley), Obremskey, W. (William), Oxner, W. (William), Cross, W.W. (William W.), Murtha, Y.M. (Yvonne M.), and Murdoch, Z. (Zoe)

Abstract

Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. Surgeons and patients were not blinded but the data analyst, while doing the analyses, remained blinded to treatment groups. The primary outcome was hip reoperation within 24 months after initial surgery to promote fracture healing, relieve pain, treat infection, or improve function. Analyses followed the intention-to-treat principle. This study was registered with ClinicalTrials.gov, number NCT00761813. Findings Between Marc

Published
2017
Full Text
View/download PDF

30. Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines

Author

Jones, A., Fujiyama, C., Blanche, C., Moore, Jw, Fuggle, S., Cranston, D., Bicknell, R., and Adrian Harris

Abstract

Hypoxia is an important regulator of vascular endothelial growth factor (VEGF) expression, and VEGF is associated with poor prognosis in bladder cancer. To investigate further the mechanisms of VEGF regulation, we examined VEGF expression by mRNA and protein analysis in four human bladder cancer cell lines, showing a progression from well to poorly differentiated phenotypes under varying conditions of confluence and hypoxia (0.1% O(2)) and with chemical mimics of hypoxia. Hypoxia significantly increased VEGF protein expression in all cell lines, although this effect was dependent on the degree of confluence. The superficial bladder cancer cell line RT4 lost hypoxia inducibility at confluence, whereas inducibility was maintained in the invasive cell lines 253J and EJ28. This pattern of VEGF expression in the invasive cell lines correlated with the expression of the transcription factor hypoxia inducible factor-1 alpha (HIF-1 alpha) and with hypoxia-inducible factor-2 alpha (HIF-2 alpha) and in RT4 correlated with a marked reduction in HIF-1 alpha inducibility at confluence. Using the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor LY 294002, we show that this VEGF hypoxia-inducible pathway regulated by HIF-1 alpha is distinct from a PI 3-kinase-dependent pathway, which regulates basal amounts of VEGF, but does not affect inducibility. Both HIF-1 alpha and HIF-2 alpha protein and mRNA were up-regulated in primary human bladder tumors (n = 12) compared with normal bladder specimens (n = 4), with significant intertumor variation. These results suggest that components of the hypoxia response pathway, including HIF-1 alpha and HIF-2 alpha, are important cofactors in the regulation of VEGF in bladder cancer and are therapeutic targets in this disease.

Published
2016

33. FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis

Author

Yakkundi, A, Bennett, R, Hernández-Negrete, I, Delalande, JM, Hanna, M, Lyubomska, O, Arthur, K, Short, A, McKeen, H, Nelson, L, McCrudden, CM, McNally, R, McClements, L, McCarthy, HO, Burns, AJ, Bicknell, R, Kissenpfennig, A, Robson, T, Yakkundi, A, Bennett, R, Hernández-Negrete, I, Delalande, JM, Hanna, M, Lyubomska, O, Arthur, K, Short, A, McKeen, H, Nelson, L, McCrudden, CM, McNally, R, McClements, L, McCarthy, HO, Burns, AJ, Bicknell, R, Kissenpfennig, A, and Robson, T

Abstract

© 2015 American Heart Association, Inc. Objective - The antitumor effects of FK506-binding protein like (FKBPL) and its extracellular role in angiogenesis are well characterized; however, its role in physiological/developmental angiogenesis and the effect of FKBPL ablation has not been evaluated. This is important as effects of some angiogenic proteins are dosage dependent. Here we evaluate the regulation of FKBPL secretion under angiogenic stimuli, as well as the effect of FKBPL ablation in angiogenesis using mouse and zebrafish models. Approach and Results - FKBPL is secreted maximally by human microvascular endothelial cells and fibroblasts, and this was specifically downregulated by proangiogenic hypoxic signals, but not by the angiogenic cytokines, VEGF or IL8. FKBPL's critical role in angiogenesis was supported by our inability to generate an Fkbpl knockout mouse, with embryonic lethality occurring before E8.5. However, whilst Fkbpl heterozygotic embryos showed some vasculature irregularities, the mice developed normally. In murine angiogenesis models, including the ex vivo aortic ring assay, in vivo sponge assay, and tumor growth assay, Fkbpl+/- mice exhibited increased sprouting, enhanced vessel recruitment, and faster tumor growth, respectively, supporting the antiangiogenic function of FKBPL. In zebrafish, knockdown of zFkbpl using morpholinos disrupted the vasculature, and the phenotype was rescued with hFKBPL. Interestingly, this vessel disruption was ineffective when zcd44 was knocked-down, supporting the dependency of zFkbpl on zCd44 in zebrafish. Conclusions - FKBPL is an important regulator of angiogenesis, having an essential role in murine and zebrafish blood vessel development. Mouse models of angiogenesis demonstrated a proangiogenic phenotype in Fkbpl heterozygotes.

Published
2015

35. Identification of novel vascular targets in lung cancer

Author

Zhuang, X, primary, Herbert, J M J, additional, Lodhia, P, additional, Bradford, J, additional, Turner, A M, additional, Newby, P M, additional, Thickett, D, additional, Naidu, U, additional, Blakey, D, additional, Barry, S, additional, Cross, D A E, additional, and Bicknell, R, additional

Published
2014
Full Text
View/download PDF

38. An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis

Author

Choudhuri, R., Zhang, H. T., Donnini, Sandra, Ziche, Marina, and Bicknell, R.

Subjects
Midkine, Neovascularization, Physiologic, Transfection, Platelet Endothelial Cell Adhesion Molecule-1, Tumor Cells, Cultured, Animals, Cytokines, Humans, Female, Endothelium, Vascular, Rabbits, Carrier Proteins, Growth Substances, Cell Division
Abstract

Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in tumorigenesis, they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular density and endothelial proliferation, implicating an angiogenic role for MK and PTN. Angiogenic activity of MK and PTN was confirmed in the rabbit corneal assay. Our data therefore identify two novel targets for antiangiogenic drug development.

Published
1997

39. Adrenomedullin and tumour angiogenesis

Author

Nikitenko, LL, Fox, SB, Kehoe, S, Rees, MCP, Bicknell, R, Nikitenko, LL, Fox, SB, Kehoe, S, Rees, MCP, and Bicknell, R

Abstract

The angiogenic activity of peptide adrenomedullin (AM) was first shown in 1998 . Since then, a number of reports have confirmed the ability of AM to induce the growth and migration of isolated vascular endothelial and smooth muscle cells in vitro and to promote angiogenesis in xenografted tumours in vivo. In addition, knockout murine models point to an essential role for AM in embryonic vasculogenesis and ischaemic revascularisation. AM expression is upregulated by hypoxia (a typical feature of solid tumours) and a potential role as a regulator of carcinogenesis and tumour progression has been proposed based on studies in vitro and in animal models. Nevertheless, translational research on AM, and in particular, confirmation of its importance in the vascularisation of human tumours has lagged behind. In this commentary, we review current progress and potential directions for future research into the role of AM in tumour angiogenesis.

Published
2006

41. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A

Author

Mura, M, primary, Swain, R K, additional, Zhuang, X, additional, Vorschmitt, H, additional, Reynolds, G, additional, Durant, S, additional, Beesley, J F J, additional, Herbert, J M J, additional, Sheldon, H, additional, Andre, M, additional, Sanderson, S, additional, Glen, K, additional, Luu, N-T, additional, McGettrick, H M, additional, Antczak, P, additional, Falciani, F, additional, Nash, G B, additional, Nagy, Z S, additional, and Bicknell, R, additional

Published
2011
Full Text
View/download PDF

44. Identification of novel vascular targets in lung cancer.

Author

Zhuang, X, Herbert, J M J, Lodhia, P, Bradford, J, Turner, A M, Newby, P M, Thickett, D, Naidu, U, Blakey, D, Barry, S, Cross, D A E, and Bicknell, R

Subjects
LUNG cancer treatment, LUNG cancer patients, BLOOD vessels, ENZYMATIC analysis, ENDOTHELIAL cells, HUMAN genome, GENE expression
Abstract

Background:Lung cancer remains the leading cause of cancer-related death, largely owing to the lack of effective treatments. A tumour vascular targeting strategy presents an attractive alternative; however, the molecular signature of the vasculature in lung cancer is poorly explored. This work aimed to identify novel tumour vascular targets in lung cancer.Methods:Enzymatic digestion of fresh tissue followed by endothelial capture with Ulex lectin-coated magnetic beads was used to isolate the endothelium from fresh tumour specimens of lung cancer patients. Endothelial isolates from the healthy and tumour lung tissue were subjected to whole human genome expression profiling using microarray technology.Results:Bioinformatics analysis identified tumour endothelial expression of angiogenic factors, matrix metalloproteases and cell-surface transmembrane proteins. Predicted novel tumour vascular targets were verified by RNA-seq, quantitative real-time PCR analysis and immunohistochemistry. Further detailed expression profiling of STEAP1 on 82 lung cancer patients confirmed STEAP1 as a novel target in the tumour vasculature. Functional analysis of STEAP1 using siRNA silencing implicates a role in endothelial cell migration and tube formation.Conclusions:The identification of cell-surface tumour endothelial markers in lung is of interest in therapeutic antibody and vaccine development. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

45. The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer.

Author

Ward, S T, Li, K K, Hepburn, E, Weston, C J, Curbishley, S M, Reynolds, G M, Hejmadi, R K, Bicknell, R, Eksteen, B, Ismail, T, Rot, A, and Adams, D H

Subjects
COLON cancer treatment, CHEMOKINE receptors, T cells, TUMOR growth, ANTINEOPLASTIC agents, LABORATORY mice
Abstract

Background:Regulatory T cells (Treg) are enriched in human colorectal cancer (CRC) where they suppress anti-tumour immunity. The chemokine receptor CCR5 has been implicated in the recruitment of Treg from blood into CRC and tumour growth is delayed in CCR5−/− mice, associated with reduced tumour Treg infiltration.Methods:Tissue and blood samples were obtained from patients undergoing resection of CRC. Tumour-infiltrating lymphocytes were phenotyped for chemokine receptors using flow cytometry. The presence of tissue chemokines was assessed. Standard chemotaxis and suppression assays were performed and the effects of CCR5 blockade were tested in murine tumour models.Results:Functional CCR5 was highly expressed by human CRC infiltrating Treg and CCR5high Treg were more suppressive than their CCR5low Treg counterparts. Human CRC-Treg were more proliferative and activated than other T cells suggesting that local proliferation could provide an alternative explanation for the observed tumour Treg enrichment. Pharmacological inhibition of CCR5 failed to reduce tumour Treg infiltration in murine tumour models although it did result in delayed tumour growth.Conclusions:CCR5 inhibition does not mediate anti-tumour effects as a consequence of inhibiting Treg recruitment. Other mechanisms must be found to explain this effect. This has important implications for anti-CCR5 therapy in CRC. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results