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5. Meeting Report: Aging Research and Drug Discovery

Author

Meron, Esther, Thaysen, Maria, Angeli, Suzanne, Antebi, Adam, Barzilai, Nir, Baur, Joseph A, Bekker-Jensen, Simon, Birkisdottir, Maria, Bischof, Evelyne, Bruening, Jens, Brunet, Anne, Buchwalter, Abigail, Cabreiro, Filipe, Cai, Shiqing, Chen, Brian H, Ermolaeva, Maria, Ewald, Collin Y, Ferrucci, Luigi, Florian, Maria Carolina, Fortney, Kristen, Freund, Adam, Georgievskaya, Anastasia, Gladyshev, Vadim N, Glass, David, Golato, Tyler, Gorbunova, Vera, Hoejimakers, Jan, Houtkooper, Riekelt H, Jager, Sibylle, Jaksch, Frank, Janssens, Georges, Jensen, Martin Borch, Kaeberlein, Matt, Karsenty, Gerard, de Keizer, Peter, Kennedy, Brian, Kirkland, James L, Kjaer, Michael, Kroemer, Guido, Lee, Kai-Fu, Lemaitre, Jean-Marc, Liaskos, David, Longo, Valter D, Lu, Yu-Xuan, MacArthur, Michael R, Maier, Andrea B, Manakanatas, Christina, Mitchell, Sarah J, Moskalev, Alexey, Niedernhofer, Laura, Ozerov, Ivan, Partridge, Linda, Passegué, Emmanuelle, Petr, Michael A, Peyer, James, Radenkovic, Dina, Rando, Thomas A, Rattan, Suresh, Riedel, Christian G, Rudolph, Lenhard, Ai, Ruixue, Serrano, Manuel, Schumacher, Björn, Sinclair, David A, Smith, Ryan, Suh, Yousin, Taub, Pam, Trapp, Alexandre, Trendelenburg, Anne-Ulrike, Valenzano, Dario Riccardo, Verburgh, Kris, Verdin, Eric, Vijg, Jan, Westendorp, Rudi GJ, Zonari, Alessandra, Bakula, Daniela, Zhavoronkov, Alex, and Scheibye-Knudsen, Morten

Subjects
Aging, aging, drug discovery, conference, AI, longevity, Biochemistry and Cell Biology, Physiology, Oncology and Carcinogenesis, Developmental Biology
Abstract

Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and investors in aging research. This year's 8th Annual Aging Research and Drug Discovery (ARDD) meeting was organized as a hybrid meeting from August 30th to September 3rd 2021 with more than 130 attendees participating on-site at the Ceremonial Hall at University of Copenhagen, Denmark, and 1800 engaging online. The conference comprised of presentations from 75 speakers focusing on new research in topics including mechanisms of aging and how these can be modulated as well as the use of AI and new standards of practices within aging research. This year, a longevity workshop was included to build stronger connections with the clinical community.

Published
2022

10. Genomic profiling of colorectal cancer in large-scale Chinese patients: amplification and somatic mutations in ERBB2.

Author

YUZHI LIU, BISCHOF, EVELYNE, ZHIQIN CHEN, JIAHUAN ZHOU, BEI ZHANG, DING ZHANG, YONG GAO, and MING QUAN

Subjects
EPIDERMAL growth factor receptors, SOMATIC mutation, SINGLE nucleotide polymorphisms, CHINESE people, COLORECTAL cancer
Abstract

Objectives: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Methods: Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes, tumor mutational burden, microsatellite instability, and programmed death ligand 1 (PD-L1) expression. Results: Among 2454 CRC patients, 85 cases (3.46%) exhibited ERBB2 amplification, and 55 cases (2.24%) carried ERBB2 mutation. p.R678Q (28%), p.V8421 (24%), and p.S310F/Y (12%) were the most prevalent of the 16 detected mutation sites. In comparison to the ERBB2 altered (alt) group, KRAS/BRAF mutations were more prevalent in ERBB2 wild-type (wt) samples (ERBB2wt vs. ERBB2alt, KRAS: 50.9% vs. 25.6%, p < 0.05; BRAF: 8.5% vs. 2.3%, p < 0.05). 32.7% (18/55) of CRCs with ERBB2 mutation exhibited microsatellite instability high (MSI-H), while no cases with HER2 amplification displayed MSI-H. Mutant genes varied between ERBB2 copy number variation (CNV) and ERBB2 single nucleotide variant (SNV); TP53 alterations tended to co-occur with ERBB2 amplification (92.3%) as opposed to ERBB2 mutation (58.3%). KRAS and PIK3CA alterations were more prevalent in ERBB2 SNV cases (KRAS/PIK3CA: 45.8%/31.2%) compared to ERBB2 amplification cases (KRAS/PIK3CA: 14.1%/7.7%). Conclusion: Our study delineates the landscape of HER2 alterations in a large-scale cohort of CRC patients from China. These findings enhance our understanding of the molecular features of Chinese CRC patients and offer valuable implications for further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Longevity biotechnology:bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Author

Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, Bakula, Daniela, Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, and Bakula, Daniela

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Published
2024

16. Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib

Author

Ge, Weiyu, primary, Wang, Yanling, additional, Quan, Ming, additional, Mao, Tiebo, additional, Bischof, Evelyne Y., additional, Xu, Haiyan, additional, Zhang, Xiaofei, additional, Li, Shumin, additional, Yue, Ming, additional, Ma, Jingyu, additional, Yang, Haiyan, additional, Wang, Lei, additional, Yu, Zhengyuan, additional, Wang, Liwei, additional, and Cui, Jiujie, additional

Published
2024
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18. Clinical trials for COVID-19 should include sex as a variable

Author

Bischof, Evelyne, Wolfe, Jeannette, and Klein, Sabra L.

Subjects
Health aspects, Clinical trials -- Health aspects, COVID-19 -- Health aspects
Abstract

The number of COVID-19 cases appears to be comparable between men and women, but the severity of disease and death is two times greater for men than for women (1, [...]

Published
2020
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20. Translational longevity medicine: a Swiss perspective in an ageing country

Author

Ruckstuhl, Marco M., Bischof, Evelyne, Blatch, Dana, Buhayer, Aliki, Goldhahn, Jörg, Battegay, Edouard, Tichelli, Andre, and Ewald, Collin Y.

Subjects
aged, longevity, delivery of health care, aging, chronic disease, humans, Switzerland, ddc:610, Medical sciences, medicine
Abstract

Breakthroughs in medical research in the last century have led to a significant extension of the human lifespan, resulting in a shift towards an elderly population worldwide. Due to the ongoing progress of global development towards elevated standards of living, this study specifically examines Switzerland as a representative nation to explore the socioeconomic and healthcare ramifications associated with an ageing population, thereby highlighting the tangible impact experienced in this context. Beyond the exhaustion of pension funds and medical budgets, by reviewing the literature and analysing publicly available data, we observe a "Swiss Japanification". Old age is associated with late-life comorbidities and an increasing proportion of time spent in poor health. To address these problems, a paradigm shift in medical practice is needed to improve health rather than respond to existing diseases. Basic ageing research is gaining momentum to be translated into therapeutic interventions and provides machine learning tools driving longevity medicine. We propose that research focus on closing the translational gap between the molecular mechanisms of ageing and a more prevention-based medicine, which would help people age better and prevent late-life chronic diseases., Swiss Medical Weekly, 153 (6), ISSN:1424-7860, ISSN:1424-3997

Published
2023
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21. Towards AI-driven longevity research: An overview

Author

Marino, Nicola, primary, Putignano, Guido, additional, Cappilli, Simone, additional, Chersoni, Emmanuele, additional, Santuccione, Antonella, additional, Calabrese, Giuliana, additional, Bischof, Evelyne, additional, Vanhaelen, Quentin, additional, Zhavoronkov, Alex, additional, Scarano, Bryan, additional, Mazzotta, Alessandro D., additional, and Santus, Enrico, additional

Published
2023
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25. Effects of Methylprednisolone on Myocardial Function and Microcirculation in Post-resuscitation: A Rat Model

Author

Wang, Changsheng, primary, Bischof, Evelyne, additional, Xu, Jing, additional, Guo, Qinyue, additional, Zheng, Guanghui, additional, Ge, Weiwei, additional, Hu, Juntao, additional, Georgescu Margarint, Elena Laura, additional, Bradley, Jennifer L., additional, Peberdy, Mary Ann, additional, Ornato, Joseph P., additional, Zhu, Changqing, additional, and Tang, Wanchun, additional

Published
2022
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26. Meeting Report:Aging Research and Drug Discovery

Author

Meron, Esther, Thaysen, Maria, Angeli, Suzanne, Antebi, Adam, Barzilai, Nir, Baur, Joseph A., Bekker-Jensen, Simon, Birkisdottir, Maria, Bischof, Evelyne, Bruening, Jens, Brunet, Anne, Buchwalter, Abigail, Cabreiro, Filipe, Cai, Shiqing, Chen, Brian H., Ermolaeva, Maria, Ewald, Collin Y., Ferrucci, Luigi, Florian, Maria Carolina, Fortney, Kristen, Freund, Adam, Georgievskaya, Anastasia, Gladyshev, Vadim N., Glass, David, Golato, Tyler, Gorbunova, Vera, Hoejimakers, Jan, Houtkooper, Riekelt H., Jager, Sibylle, Jaksch, Frank, Janssens, Georges, Jensen, Martin Borch, Kaeberlein, Matt, Karsenty, Gerard, de Keizer, Peter, Kennedy, Brian, Kirkland, James L., Kjaer, Michael, Kroemer, Guido, Lee, Kai Fu, Lemaitre, Jean Marc, Liaskos, David, Longo, Valter D., Lu, Yu Xuan, MacArthur, Michael R., Maier, Andrea B., Manakanatas, Christina, Mitchell, Sarah J., Moskalev, Alexey, Niedernhofer, Laura, Ozerov, Ivan, Partridge, Linda, Passegué, Emmanuelle, Petr, Michael A., Peyer, James, Radenkovic, Dina, Rando, Thomas A., Rattan, Suresh, Riedel, Christian G., Rudolph, Lenhard, Ai, Ruixue, Serrano, Manuel, Schumacher, Björn, Sinclair, David A., Smith, Ryan, Suh, Yousin, Taub, Pam, Trapp, Alexandre, Trendelenburg, Anne Ulrike, Valenzano, Dario Riccardo, Verburgh, Kris, Verdin, Eric, Vijg, Jan, Westendorp, Rudi G.J., Zonari, Alessandra, Bakula, Daniela, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, Meron, Esther, Thaysen, Maria, Angeli, Suzanne, Antebi, Adam, Barzilai, Nir, Baur, Joseph A., Bekker-Jensen, Simon, Birkisdottir, Maria, Bischof, Evelyne, Bruening, Jens, Brunet, Anne, Buchwalter, Abigail, Cabreiro, Filipe, Cai, Shiqing, Chen, Brian H., Ermolaeva, Maria, Ewald, Collin Y., Ferrucci, Luigi, Florian, Maria Carolina, Fortney, Kristen, Freund, Adam, Georgievskaya, Anastasia, Gladyshev, Vadim N., Glass, David, Golato, Tyler, Gorbunova, Vera, Hoejimakers, Jan, Houtkooper, Riekelt H., Jager, Sibylle, Jaksch, Frank, Janssens, Georges, Jensen, Martin Borch, Kaeberlein, Matt, Karsenty, Gerard, de Keizer, Peter, Kennedy, Brian, Kirkland, James L., Kjaer, Michael, Kroemer, Guido, Lee, Kai Fu, Lemaitre, Jean Marc, Liaskos, David, Longo, Valter D., Lu, Yu Xuan, MacArthur, Michael R., Maier, Andrea B., Manakanatas, Christina, Mitchell, Sarah J., Moskalev, Alexey, Niedernhofer, Laura, Ozerov, Ivan, Partridge, Linda, Passegué, Emmanuelle, Petr, Michael A., Peyer, James, Radenkovic, Dina, Rando, Thomas A., Rattan, Suresh, Riedel, Christian G., Rudolph, Lenhard, Ai, Ruixue, Serrano, Manuel, Schumacher, Björn, Sinclair, David A., Smith, Ryan, Suh, Yousin, Taub, Pam, Trapp, Alexandre, Trendelenburg, Anne Ulrike, Valenzano, Dario Riccardo, Verburgh, Kris, Verdin, Eric, Vijg, Jan, Westendorp, Rudi G.J., Zonari, Alessandra, Bakula, Daniela, Zhavoronkov, Alex, and Scheibye-Knudsen, Morten

Abstract

Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and investors in aging research. This year's 8th Annual Aging Research and Drug Discovery (ARDD) meeting was organized as a hybrid meeting from August 30th to September 3rd 2021 with more than 130 attendees participating on-site at the Ceremonial Hall at University of Copenhagen, Denmark, and 1800 engaging online. The conference comprised of presentations from 75 speakers focusing on new research in topics including mechanisms of aging and how these can be modulated as well as the use of AI and new standards of practices within aging research. This year, a longevity workshop was included to build stronger connections with the clinical community.

Published
2022

27. Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform

Author

Pun, Frank W., primary, Liu, Bonnie Hei Man, additional, Long, Xi, additional, Leung, Hoi Wing, additional, Leung, Geoffrey Ho Duen, additional, Mewborne, Quinlan T., additional, Gao, Junli, additional, Shneyderman, Anastasia, additional, Ozerov, Ivan V., additional, Wang, Ju, additional, Ren, Feng, additional, Aliper, Alexander, additional, Bischof, Evelyne, additional, Izumchenko, Evgeny, additional, Guan, Xiaoming, additional, Zhang, Ke, additional, Lu, Bai, additional, Rothstein, Jeffrey D., additional, Cudkowicz, Merit E., additional, and Zhavoronkov, Alex, additional

Published
2022
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30. Dance of the Porcupines: A View into the Rapid Development of Covid-19 Vaccines from Around the World — Part 2

Author

Levin, Jeremy, Bischof, Evelyne, and Prewitt, Edward

Subjects
Clip
Abstract

The pharma industry came together under extraordinary circumstances to develop a vaccine for Covid-19. Biotech and AI will play a major role in what’s to come next., Summary Jeremy Levin, CEO of Ovid Therapeutics and Chairman of the Biotechnology Innovation Organization, and Evelyne Bischof, Associate Professor at the Shanghai University School of Medicine and Health Sciences and a researcher at University Hospital in Basel, Switzerland, discuss the complexity of vaccine development for Covid-19, and what it can teach us for the future of vaccines, both as clinicians and patients.

Published
2021

31. Dance of the Porcupines: A View into the Rapid Development of Covid-19 Vaccines from Around the World — Part 1

Author

Levin, Jeremy, Bischof, Evelyne, and Prewitt, Edward

Subjects
Clip
Abstract

The pharma industry came together under extraordinary circumstances to develop a vaccine for Covid-19. Biotech and AI will play a major role in what’s to come next., Summary Jeremy Levin, CEO of Ovid Therapeutics and Chairman of the Biotechnology Innovation Organization, and Evelyne Bischof, Associate Professor at the Shanghai University School of Medicine and Health Sciences and a researcher at University Hospital in Basel, Switzerland, discuss the complexity of vaccine development for Covid-19, and what it can teach us for the future of vaccines, both as clinicians and patients.

Published
2021

35. Additional file 1 of Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation

Author

Jinhui Lü, Chuyi Zhang, Junyi Han, Xu, Zhen, Li, Yuan, Lixiao Zhen, Zhao, Qian, Yuefan Guo, Zhaohui Wang, Bischof, Evelyne, and Yu, Zuoren

Abstract

Additional file 1 Figure S1: MTT assays showing uninfluenced cell proliferation in MDA-MB-231 cells by knockdown of miR-221 and/or miR-222 under starvation condition. Figure S2: Quantitative real-time PCR analysis showing increase of p27 expression at mRNA level by anti-miR-221 and/or anti-miR-222 under regular cell culture condition, but not under starvation culture condition. Data are derived from three independent analyses, and presented as mean ± SEM (n = 3). **p

Published
2020
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37. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.

Author

Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, Jamil A, Kulaga A, Bhatti A, Yaden B, Pedersen BK, Schumacher B, Djordjevic B, Kennedy B, Chen C, Huang CY, Correll CU, Murphy CT, Ewald CY, Chen D, Valenzano DR, Sołdacki D, Erritzoe D, Meyer D, Sinclair DA, Chini EN, Teeling EC, Morgen E, Verdin E, Vernet E, Pinilla E, Fang EF, Bischof E, Mercken EM, Finger F, Kuipers F, Pun FW, Gyülveszi G, Civiletto G, Zmudze G, Blander G, Pincus HA, McClure J, Kirkland JL, Peyer J, Justice JN, Vijg J, Gruhn JR, McLaughlin J, Mannick J, Passos J, Baur JA, Betts-LaCroix J, Sedivy JM, Speakman JR, Shlain J, von Maltzahn J, Andreasson KI, Moody K, Palikaras K, Fortney K, Niedernhofer LJ, Rasmussen LJ, Veenhoff LM, Melton L, Ferrucci L, Quarta M, Koval M, Marinova M, Hamalainen M, Unfried M, Ringel MS, Filipovic M, Topors M, Mitin N, Roy N, Pintar N, Barzilai N, Binetti P, Singh P, Kohlhaas P, Robbins PD, Rubin P, Fedichev PO, Kamya P, Muñoz-Canoves P, de Cabo R, Faragher RGA, Konrad R, Ripa R, Mansukhani R, Büttner S, Wickström SA, Brunemeier S, Jakimov S, Luo S, Rosenzweig-Lipson S, Tsai SY, Dimmeler S, Rando TA, Peterson TR, Woods T, Wyss-Coray T, Finkel T, Strauss T, Gladyshev VN, Longo VD, Dwaraka VB, Gorbunova V, Acosta-Rodríguez VA, Sorrentino V, Sebastiano V, Li W, Suh Y, Zhavoronkov A, Scheibye-Knudsen M, and Bakula D

Subjects
Humans, Aging physiology, Geroscience methods, Artificial Intelligence, Biomarkers metabolism, Biotechnology methods, Longevity physiology
Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Published
2024
Full Text
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38. Translational longevity medicine: a Swiss perspective in an ageing country.

Author

Ruckstuhl MM, Bischof E, Blatch D, Buhayer A, Goldhahn J, Battegay E, Tichelli A, and Ewald CY

Subjects
Humans, Aged, Switzerland, Delivery of Health Care, Chronic Disease, Longevity, Aging
Abstract

Breakthroughs in medical research in the last century have led to a significant extension of the human lifespan, resulting in a shift towards an elderly population worldwide. Due to the ongoing progress of global development towards elevated standards of living, this study specifically examines Switzerland as a representative nation to explore the socioeconomic and healthcare ramifications associated with an ageing population, thereby highlighting the tangible impact experienced in this context. Beyond the exhaustion of pension funds and medical budgets, by reviewing the literature and analysing publicly available data, we observe a "Swiss Japanification". Old age is associated with late-life comorbidities and an increasing proportion of time spent in poor health. To address these problems, a paradigm shift in medical practice is needed to improve health rather than respond to existing diseases. Basic ageing research is gaining momentum to be translated into therapeutic interventions and provides machine learning tools driving longevity medicine. We propose that research focus on closing the translational gap between the molecular mechanisms of ageing and a more prevention-based medicine, which would help people age better and prevent late-life chronic diseases.

Published
2023
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