30 results on '"Bodeau-Livinec, Florence"'
Search Results
2. Toxics (Pb, Cd) and trace elements (Zn, Cu, Mn) in women during pregnancy and at delivery, South Benin, 2014–2015
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Guy, Marine, Accrombessi, Manfred, Fievet, Nadine, Yovo, Emmanuel, Massougbodji, Achille, Le Bot, Barbara, Glorennec, Philippe, Bodeau-Livinec, Florence, and Briand, Valérie
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- 2018
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3. Mapping competency in public health training – experience of the Europubhealth consortium.
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Grimaud, Olivier, Foucrier, Mathilde, Czabanowska, Kasia, Barnes, Sarah, Bauernfeind, Ariane, Clemens, Timo, Codd, Mary, Donneau, Anne-Françoise, Sowada, Christoph, Keller, Catherine, Gely-Pernot, Aurore, Mueller, Judith, Guevel, Marie-Renée, Bodeau-Livinec, Florence, and Théault, Laurence
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CONSORTIA ,PUBLIC health education ,PUBLIC health ,WORLD health ,EDUCATIONAL objectives - Abstract
Background: Public health education aims at producing a competent workforce. The WHO-ASPHER framework proposes a set of relevant public health competencies organised in 10 sections (e.g. science practice, leadership, law policies and ethics etc). As part of the Europubhealth (EPH) consortium, eight universities collaborate for the delivery of a 2-year international public health master course. The training pathway includes a first "foundation" year, with a choice of four options (components), and a second "specialisation" year with a choice of seven components. In 2020, EPH consortium decided to use the WHO-ASPHER framework in order to map the competencies addressed and the level of proficiency targeted by each component of its master course. Methods: An 84-item questionnaire covering the whole WHO-ASPHER framework was sent to the 11 EPH component coordinators, asking them to rate the proficiency levels targeted at the end of their courses. Answers from each coordinator were summarised by calculating mean proficiency levels for each of the 10 competency sections. We used Bland & Altman plots to explore heterogeneity of answers and then calculated transformed scores to account for rating heterogeneity. We use tabulation and a heat map to explore patterns of proficiency levels across components. Results: There were differences in overall proficiency levels between years with, as expected, higher scores in year two. Year one components reached medium to high proficiency scores for the sections "science practice", "health promotion" and "communication" with scores ranging from 2.6 to 3 (on a 1-low to 4-high scale). When compared with year one on a heat-map, year two components displayed more contrasted profiles, typically aiming for high proficiency level (i.e. scores above 3.5) on 3 out of the 10 sections of competencies. Except for the "collaborations and partnership" section, the training pathways offered by the EPH master course seem to offer opportunities for a high proficiency level in all domains of competencies. Conclusions: The mapping proved a useful exercise to identify strengths and complementarities among the EPH consortium. The results suggest that the EPH master course is coherent and offers students opportunities to gain proficiency in most competencies relevant to public health practice. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Perinatal exposure to chlordecone and infant growth
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Costet, Nathalie, Pelé, Fabienne, Comets, Emmanuelle, Rouget, Florence, Monfort, Christine, Bodeau-Livinec, Florence, Linganiza, Elsie M, Bataille, Henri, Kadhel, Philippe, Multigner, Luc, and Cordier, Sylvaine
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- 2015
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5. Lead Exposure in Infancy and Subsequent Growth in Beninese Children
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Ahmadi, Shukrullah, primary, Botton, Jérémie, additional, Zoumenou, Roméo, additional, Ayotte, Pierre, additional, Fievet, Nadine, additional, Massougbodji, Achille, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional
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- 2022
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6. Soil-transmitted helminth infection in pregnancy and long-term child neurocognitive and behavioral development: A prospective mother-child cohort in Benin
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Garrison, Amanda, Boivin, Michael, Khoshnood, Babak, Courtin, David, Alao, Jules, Mireku, Michael, Ibikounle, Moudachirou, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Michigan State University [East Lansing], Michigan State University System, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), University of Lincoln, Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Fondation de France (2015 00060746), Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD- R21-HD060524), European and Developing Countries Clinical Trials Partnership (EDCTP- IP.07.31080.002), Bill and Melinda Gates Foundation, EHESP, SCD, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), and Université d’Abomey-Calavi (UAC)
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Maternal Health ,Emotions ,RC955-962 ,Helminthiasis ,Child Behavior ,Social Sciences ,Cohort Studies ,C890 Psychology not elsewhere classified ,Soil ,Families ,C810 Applied Psychology ,Child Development ,Cognition ,Medical Conditions ,Pregnancy ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Arctic medicine. Tropical medicine ,Medicine and Health Sciences ,Psychology ,Prospective Studies ,C820 Developmental Psychology ,Child ,Children ,Immune Response ,Cognitive Neurology ,Neuropsychological testing ,Eukaryota ,Obstetrics and Gynecology ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Cognitive impairment ,Neurology ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Female ,Public aspects of medicine ,RA1-1270 ,B990 Subjects Allied to Medicine not elsewhere classified ,Research Article ,Adult ,Helminth infections ,Cognitive Neuroscience ,Immunology ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Signs and Symptoms ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Helminths ,Parasitic Diseases ,Humans ,Animals ,Inflammation ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Organisms ,Biology and Life Sciences ,Invertebrates ,[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Age Groups ,Hookworms ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Pregnancy Complications, Parasitic ,People and Places ,Women's Health ,Cognitive Science ,Population Groupings ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Clinical Medicine ,Zoology ,[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Neuroscience - Abstract
Background An estimated 30% of women in Sub-Saharan Africa suffer from soil-transmitted helminth infection during pregnancy (SHIP), which has been shown to increase risk of pre-term birth, low birth weight, and maternal anemia. A previous study in Benin found that SHIP was associated with impaired cognitive and gross motor development scores in 635 one-year-old children. The objective of the present study was to follow children prospectively to investigate whether the association between SHIP and child neurocognitive and behavioral development persisted at age six. Principal findings Our prospective child cohort included 487 live-born singletons of pregnant women enrolled in the Malaria in Pregnancy Preventive Alternative Drugs clinical trial in Allada, Benin. SHIP was assessed at three antenatal visits (ANVs) through collection and testing of stool samples. Neurocognitive and behavioral development was assessed in six-year-old children by trained investigators using the Kaufman Assessment Battery for Children 2nd edition and the parent-reported Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models generated coefficients and 95% confidence intervals and potential mediating factors were tested. Prevalence of SHIP was 13% at the 1st ANV, 9% at the 2nd ANV, and 1% at delivery. SHIP was not associated with low neurocognitive scores in children at six years. Higher SDQ internalizing scores, indicating increased emotional impairments in children, were associated with helminth infection at the 2nd ANV/delivery 1.07 (95% CI 0.15, 2.00) and at least once during pregnancy 0.79 (95% CI 0.12, 1.46) in adjusted models. Mediation analysis did not reveal significant indirect effects of several mediators on this association. Conclusions Our study shows that while SHIP is not associated with impaired long-term neurocognitive development, infections may have significant negative impacts on emotional development in six-year-old children. SHIP remains a critical public health issue, and adequate prevention and treatment protocols should be enforced in low- and middle-income countries., Author summary Soil-transmitted helminth infections impact 1.5 billion individuals, primarily in low- and middle- income countries, each year and contribute to malnutrition, anemia, and impaired neurocognitive development in children. However, these infections in pregnancy and their impact on offspring have been less studied. One previous study found associations between soil-transmitted helminth infection during pregnancy and impaired cognitive functioning in offspring one year after birth. The current study aimed to follow these children prospectively until six years in order to confirm whether these associations persisted or not. Infections during pregnancy were no longer associated with cognitive or motor functioning in children; however, infections were associated with impaired behavioral development. Animal-based models have hypothesized maternal inflammation and poor birth outcomes to be the mechanisms behind this relationship; however, our findings did not support these mechanisms. This is one of very few prospective cohort studies in Sub-Saharan Africa to investigate these associations, and more research is needed to corroborate results. Limitations include limited power and the possibility that results are due to chance from multiple statistical tests. Adequate and accessible prevention and treatment efforts in pregnancy and childhood should be provided to populations in low- and middle- income countries at high risk of infection.
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- 2021
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7. Comparison of growth models to describe growth from birth to 6 years in a Beninese cohort of children with repeated measurements
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Ahmadi, Shukrullah, Bodeau-Livinec, Florence, Zoumenou, Roméo, Garcia, André, Courtin, David, Alao, Jules, Fievet, Nadine, Cot, Michel, Massougbodji, Achille, Botton, Jérémie, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de Recherche pour le Développement [Cotonou, Bénin] (IRD), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Pharmaco-épidémiologie des produits de santé et sécurité sanitaire [Site de Saint Denis] (GIS EPIPHARE - ANSM), Agence nationale de sécurité du médicament et des produits de santé [Saint-Denis] (ANSM), European and Developing Countries Clinical Trials Partnership (EDCTP)IP.2007.31080.002Malaria in Pregnancy ConsortiumInstituto de Salud Carlos IIIPI08/0564Federal Ministry of Education & Research (BMBF)FKZ: da01KA0803Institut de Recherche pour le Developpement (IRD), FranceBill & Melinda Gates FoundationCGIARFrench National Research Agency (ANR)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)R21-HD060524Fondation de France00079816, ANR-10-PRSP-0012,TOLIMMUNPAL(2010), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), Université d’Abomey-Calavi (UAC), EHESP, SCD, and PROGRAMME DE RECHERCHE EN SANTE PUBLIQUE - - TOLIMMUNPAL2010 - ANR-10-PRSP-0012 - PRSP - VALID
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Male ,Epidemiology ,statistics & research methods ,paediatrics ,Cohort Studies ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Pregnancy ,Benin ,Humans ,Prospective Studies ,Child ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,public health ,Body Weight ,Infant, Newborn ,Infant ,Bayes Theorem ,Body Height ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Child, Preschool ,Medicine ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female - Abstract
International audience; Objective To select a growth model that best describes individual growth trajectories of children and to present some growth characteristics of this population.Settings Participants were selected from a prospective cohort conducted in three health centres (Allada, Sekou and Attogon) in a semirural region of Benin, sub-Saharan Africa.Participants Children aged 0 to 6 years were recruited in a cohort study with at least two valid height and weight measurements included (n=961).Primary and secondary outcome measures This study compared the goodness-of-fit of three structural growth models (Jenss-Bayley, Reed and a newly adapted version of the Gompertz growth model) on longitudinal weight and height growth data of boys and girls. The goodness-of-fit of the models was assessed using residual distribution over age and compared with the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). The best-fitting model allowed estimating mean weight and height growth trajectories, individual growth and growth velocities. Underweight, stunting and wasting were also estimated at age 6 years.Results The three models were able to fit well both weight and height data. The Jenss-Bayley model presented the best fit for weight and height, both in boys and girls. Mean height growth trajectories were identical in shape and direction for boys and girls while the mean weight growth curve of girls fell slightly below the curve of boys after neonatal life. Finally, 35%, 27.7% and 8% of boys; and 34%, 38.4% and 4% of girls were estimated to be underweight, wasted and stunted at age 6 years, respectively.Conclusion The growth parameters of the best-fitting Jenss-Bayley model can be used to describe growth trajectories and study their determinants.
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- 2020
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8. Recent trends in visual impairment and blindness in the UK
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Bodeau-Livinec, Florence, Surman, Geraldine, Kaminski, Monique, Wilkinson, Andrew R., Ancel, Pierre-Yves, and Kurinczuk, Jennifer J.
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Vision disorders in children -- Forecasts and trends ,Vision disorders in children -- Risk factors ,Vision disorders in children -- Demographic aspects ,Birth weight, Low -- Health aspects ,Infants (Premature) -- Health aspects ,Market trend/market analysis - Published
- 2007
9. Follow-Up of Elevated Blood Lead Levels and Sources in a Cohort of Children in Benin
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Ahmadi, Shukrullah, primary, Le Bot, Barbara, additional, Zoumenou, Roméo, additional, Durand, Séverine, additional, Fiévet, Nadine, additional, Ayotte, Pierre, additional, Massougbodji, Achille, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional
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- 2020
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10. Malaria and gravidity interact to modify maternal haemoglobin concentrations during pregnancy
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Ouédraogo Smaïla, Bodeau-Livinec Florence, Briand Valérie, Huynh Bich-Tram, Koura Ghislain K, Accrombessi Manfred MK, Fievet Nadine, Massougbodji Achille, Deloron Philippe, and Cot Michel
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Anaemia ,Gravidity ,Malaria ,Iron deficiency ,Prevention ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Primigravidity is one of the main risk factors for both malaria and anaemia. Since the implementation of intermittent preventive treatment (IPTp) in sub-Saharan Africa, the relationship between anaemia and gravidity and its evolution during pregnancy has been little explored. This study aimed to evaluate the impact of gravidity on the variation of haemoglobin during pregnancy according to the timing of gestation. Methods Data from three studies carried out in nearby areas in south Benin (Ouidah, Comé, Allada) between 2005 and 2012 were analysed. At inclusion (first antenatal visit, ANV1) women’s age, area of residence, schooling, gravidity, gestational age, weight and height were recorded. Thick blood smears were performed on ANV1, second visit (ANV2) and at delivery. In Allada, women’s serum ferritin and CRP concentrations were also assessed. The impact of gravidity on maternal haemoglobin (Hb) was analysed using a logistic or linear regression depending on the outcome. The statistical significance was set to P < 0.05. Results In total, data from 3,591 pregnant women were analysed. Both univariate and multivariate analyses showed a constant association between Hb concentrations and gravidity in the three periods of Hb assessment (ANV1, ANV2 and delivery). Mean Hb concentration was significantly lower in primigravidae than in multigravidae at ANV1 (mean difference = -2.4 g/L, CI 95%: [-3.4, -1.4], P < 0.001). Afterwards, there was a significant increase in primigravidae only, with a tendency to reversal between primigravidae and multigravidae, which was confirmed at delivery (mean difference = 2.8 g/L, CI 95%: [1.3, 4.2], P < 0.001). The prevalence of malaria infection was halved between ANV1 and delivery in primigravidae while it decreased by only 38% among multigravidae, who were less prone to malaria infection (prevalence at ANV1, 20% and 10% respectively). Iron deficiency was more common in multigravidae, and it decreased slightly in this group between ANV1 and delivery. Conclusion In a context of IPTp, Hb levels improved progressively throughout pregnancy in primigravidae, likely as a result of reduction in malaria infection. In multigravidae, the improvement was less perceptible and anaemia was mainly due to iron deficiency.
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- 2012
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11. Blood lead level in infants and subsequent risk of malaria: A prospective cohort study in Benin, Sub-Saharan Africa
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Garrison, Amanda, primary, Khoshnood, Babak, additional, Courtin, David, additional, Milet, Jacqueline, additional, Garcia, André, additional, Massougbodji, Achille, additional, Ayotte, Pierre, additional, Cot, Michel, additional, and Bodeau-Livinec, Florence, additional
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- 2019
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12. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study
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Pierrat, Véronique, Marchand-Martin, Laetitia, Arnaud, Catherine, Kaminski, Monique, Resche-Rigon, Matthieu, Lebeaux, Cécile, Bodeau-Livinec, Florence, Morgan, Andrei S., Goffinet, François, Marret, Stéphane, Ancel, Pierre-Yves, Rozé, Jean-Christophe, Flamant, Cyril, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Centre Hospitalier Universitaire de Lille (CHU de Lille), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de l'information médicale et de la biostatistique [AP-HP Hôpital Saint-Louis], AP-HP Hôpital Saint-Louis, Département Méthodes quantitatives en santé publique (METIS), École des Hautes Études en Santé Publique [EHESP] (EHESP), DHU Risques Et Grossesse, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Service de pédiatrie néonatale et réanimation - neuropédiatrie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), CIC - Mère Enfant Necker Cochin Paris Centre (CIC 1419), CHU Cochin [AP-HP]-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), This project has been funded with support from the following organisations: The French Institute of Public Health Research/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), The National Research Agency through the French EQUIPEX program of investments in the future (reference ANR-11-EQPX-0038), the PREMUP Foundation, Fondation de France (reference 00050329), and Fondation pour la Recherche Médicale (reference SPF20160936356)., ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie néonatale et réanimation - neuropédiatrie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), pierrat, veronique, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique ( CRESS - U1153 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Universitaire de Lille ( CHU de Lille ), Épidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département Méthodes quantitatives en santé publique ( METIS ), École des Hautes Études en Santé Publique [EHESP] ( EHESP ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Assistance publique - Hôpitaux de Paris (AP-HP), CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Hôpital Charles Nicolle [Rouen], Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques ( GPMCND ), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institute for Research and Innovation in Biomedicine ( IRIB ), CIC - Mère Enfant Necker Cochin Paris Centre ( CIC 1419 ), CHU Cochin [AP-HP]-Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance ( 2011 ), CHU Lille, Université de Lille, Hôpital Jeanne de Flandre [Lille], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Université Toulouse III - Paul Sabatier [UT3], and Hôpital Saint-Louis
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Male ,Pediatrics ,Developmental Disabilities ,[ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Infant, Premature, Diseases ,Blindness ,Population based cohort ,Corrected Age ,0302 clinical medicine ,030202 anesthesiology ,Outcome Assessment, Health Care ,MESH: Blindness/epidemiology ,Blindness/etiology ,Cerebral Palsy/epidemiology ,Cerebral Palsy/etiology ,Child, Preschool ,Developmental Disabilities/epidemiology ,Developmental Disabilities/etiology ,Female ,Follow-Up Studies ,France/epidemiology ,Gestational Age ,Hearing Loss/epidemiology ,Hearing Loss/etiology ,Humans ,Infant, Extremely Premature ,Infant, Premature, Diseases/epidemiology ,Infant, Premature, Diseases/mortality ,Infant, Premature, Diseases/physiopathology ,Outcome Assessment (Health Care) ,Prospective Studies ,Survivors ,030212 general & internal medicine ,Prospective cohort study ,education.field_of_study ,030219 obstetrics & reproductive medicine ,Gestational age ,Gross Motor Function Classification System ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,General Medicine ,3. Good health ,Gestation ,France ,Cohort study ,medicine.medical_specialty ,Pédiatrie ,Population ,Cerebral palsy ,03 medical and health sciences ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,030225 pediatrics ,medicine ,education ,Hearing Loss ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,business.industry ,Cerebral Palsy ,Research ,medicine.disease ,Confidence interval ,MESH : Blindness/epidemiology ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
International audience; Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks' gestation in 2011, and to evaluate changes since 1997.Design Population based cohort studies, EPIPAGE and EPIPAGE-2.Setting France.Participants 5567 neonates born alive in 2011 at 22-34 completed weeks' gestation, with 4199 survivors at 2 years corrected age included in follow-up. Comparison of outcomes reported for 3334 (1997) and 2418 (2011) neonates born alive in the nine regions participating in both studies.Main outcome measures Survival; cerebral palsy (2000 European consensus definition); scores below threshold on the neurodevelopmental Ages and Stages Questionnaire (ASQ; at least one of five domains below threshold) if completed between 22 and 26 months corrected age, in children without cerebral palsy, blindness, or deafness; and survival without severe or moderate neuromotor or sensory disabilities (cerebral palsy with Gross Motor Function Classification System levels 2-5, unilateral or bilateral blindness or deafness). Results are given as percentage of outcome measures with 95% confidence intervals.Results Among 5170 liveborn neonates with parental consent, survival at 2 years corrected age was 51.7% (95% confidence interval 48.6% to 54.7%) at 22-26 weeks' gestation, 93.1% (92.1% to 94.0%) at 27-31 weeks' gestation, and 98.6% (97.8% to 99.2%) at 32-34 weeks' gestation. Only one infant born at 22-23 weeks survived. Data on cerebral palsy were available for 3599 infants (81.0% of the eligible population). The overall rate of cerebral palsy at 24-26, 27-31, and 32-34 weeks' gestation was 6.9% (4.7% to 9.6%), 4.3% (3.5% to 5.2%), and 1.0% (0.5% to 1.9%), respectively. Responses to the ASQ were analysed for 2506 children (56.4% of the eligible population). The proportion of children with an ASQ result below threshold at 24-26, 27-31, and 32-34 weeks' gestation were 50.2% (44.5% to 55.8%), 40.7% (38.3% to 43.2%), and 36.2% (32.4% to 40.1%), respectively. Survival without severe or moderate neuromotor or sensory disabilities among live births increased between 1997 and 2011, from 45.5% (39.2% to 51.8%) to 62.3% (57.1% to 67.5%) at 25-26 weeks' gestation, but no change was observed at 22-24 weeks' gestation. At 32-34 weeks' gestation, there was a non-statistically significant increase in survival without severe or moderate neuromotor or sensory disabilities (P=0.61), but the proportion of survivors with cerebral palsy declined (P=0.01).Conclusions In this large cohort of preterm infants, rates of survival and survival without severe or moderate neuromotor or sensory disabilities have increased during the past two decades, but these children remain at high risk of developmental delay.
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- 2017
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13. Consequences of prenatal geophagy for maternal prenatal health, risk of childhood geophagy and child psychomotor development
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Mireku, Michael O., primary, Davidson, Leslie L., additional, Zoumenou, Romeo, additional, Massougbodji, Achille, additional, Cot, Michel, additional, and Bodeau‐Livinec, Florence, additional
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- 2018
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14. Hunting, Sale, and Consumption of Bushmeat Killed by Lead-Based Ammunition in Benin
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Ahmadi, Shukrullah, primary, Maman, Suzanne, additional, Zoumenou, Roméo, additional, Massougbodji, Achille, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional
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- 2018
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15. Cohort profile: effect of malaria in early pregnancy on fetal growth in Benin (RECIPAL preconceptional cohort)
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Accrombessi, Manfred, primary, Yovo, Emmanuel, additional, Cottrell, Gilles, additional, Agbota, Gino, additional, Gartner, Agnès, additional, Martin-Prevel, Yves, additional, Fanou-Fogny, Nadia, additional, Djossinou, Diane, additional, Zeitlin, Jennifer, additional, Tuikue-Ndam, Nicaise, additional, Bodeau-Livinec, Florence, additional, Houzé, Sandrine, additional, Jackson, Nicola, additional, Ayemonna, Paul, additional, Massougbodji, Achille, additional, Cot, Michel, additional, Fievet, Nadine, additional, and Briand, Valérie, additional
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- 2018
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16. Country-level and individual correlates of overweight and obesity among primary school children: a cross-sectional study in seven European countries
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Mireku, Michael, Boivin, Michael, Davidson, Leslie, Ouédraogo, Smaïla, Koura, Ghislain, Alao, Maroufou, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Olaya, Beatriz, Moneta, Maria Victoria, Pez, Ondine, Bitfoi, Adina, Carta, Mauro Giovanni, Eke, Ceyda, Goelitz, Dietmar, Keyes, Katherine, Kuijpers, Rowella, Lesinskiene, Sigita, Mihova, Zlatka, Otten, Roy, Fermanian, Christophe, Haro, Josep Maria, Kovess, Viviane, Centre Hospitalier Universitaire Yalgado Ouédraogo (CHUYO), parasitology and mycology education, Science and health faculty, Santé de la mère et de l'enfant en milieu tropical : épidémiologie génétique et périnatale, Université Paris Descartes - Paris 5 (UPD5), École des Hautes Études en Santé Publique [EHESP] (EHESP), Unité de recherche clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré, and Universitat de Barcelona
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Male ,Gerontology ,Pediatric Obesity ,Epidemiology ,Cross-sectional study ,Overweight ,Body Mass Index ,Lietuva (Lithuania) ,Primary school children ,Risk Factors ,School children ,Prevalence ,Turkija (Turkey) ,Parent-Child Relations ,Vokietija (Germany) ,Child ,Children ,Public health ,Schools ,Only child ,Europe ,Italija (Italy) ,Obesitat ,Female ,Correlation (Statistics) ,Rumunija (Romania) ,medicine.symptom ,Europa ,Infants ,Research Article ,Individual and population-level correlates ,medicine.medical_specialty ,Eastern and Western Europe ,Sveikata / Health ,Food Preferences ,Obesity ,medicine ,Humans ,Nyderlandai (Netherlands) ,Epidemiologia ,Exercise ,Life Style ,business.industry ,Statistics--Medical ,Body Weight ,Public Health, Environmental and Occupational Health ,medicine.disease ,Vaikai / Children ,Cross-Sectional Studies ,Logistic Models ,Obesity in children ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Bulgarija (Bulgaria) ,Biostatistics ,business ,Body mass index ,Demography - Abstract
Background: The present study aims to estimate childhood overweight and obesity prevalence and their association with individual and population-level correlates in Eastern and Western European countries. Methods: Data were obtained from the School Children Mental Health in Europe, a cross-sectional survey conducted in 2010 in Italy, Germany, the Netherlands, Romania, Bulgaria, Lithuania and Turkey. The sample consists of 5,206 school children aged 6 to 11 years old. Information on socio-demographics, children’s height and weight, life-style and parental attitude were reported by the mothers. Country-level indicators were obtained through several data banks. Overweight and obesity in children were calculated according to the international age and gender-specific child Body Mass Index cut-off points. Multivariable logistic regression models included socio-demographic, lifestyle, mothers’ attitude, and country-level indicators to examine the correlates of overweight. Results: Overall prevalence was 15.6% (95% CI = 19.3-21.7%) for overweight and 4.9% (95% CI = 4.3-5.6%) for obesity. In overweight (including obesity), Romanian children had the highest prevalence (31.4%, 95% CI = 28.1-34.6%) and Italian the lowest (10.4%, 95% CI = 8.1-12.6%). Models in the pooled sample showed that being younger (aOR = 0.93, 95% = CI 0.87-0.97), male (aOR = 1.24, 95% CI = 1.07-1.43), an only child (aOR = 1.40, 95% CI = 1.07-1.84), spending more hours per week watching TV (aOR = 1.01, 95% CI =1.002-1.03), and living in an Eastern Country were associated with greater risk of childhood overweight (including obesity). The same predictors were significantly associated with childhood overweight in the model conducted in the Eastern region, but not in the West. Higher Gross Domestic Product and Real Domestic Product, greater number of motor and passenger vehicles, higher percentage of energy available from fat, and more public sector expenditure on health were also associated with lower risk for childhood overweight after adjusting for covariables in the pooled sample and in the east of Europe, but not in the West. Conclusions: Prevalence rates of overweight and obesity in school children is still high, especially in Eastern regions, with some socio-demographic factors and life-styles associated with being overweight. It is also in the Eastern region itself where better macro-economic indicators are related with lower rates of childhood overweight. This represents a public health concern that deserves special attention in those countries undertaking economic and political transitions. Keywords: Overweight, Obesity, School children, Eastern and Western Europe, Individual and population-level correlates.
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- 2015
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17. Mental health of college students and their non-college-attending peers: results from a large French cross-sectional survey
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Kovess-Masfety, Viviane, primary, Leray, Emmanuelle, additional, Denis, Laure, additional, Husky, Mathilde, additional, Pitrou, Isabelle, additional, and Bodeau-Livinec, Florence, additional
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- 2016
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18. Elevated Blood Lead Levels in Infants and Mothers in Benin and Potential Sources of Exposure
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Bodeau-Livinec, Florence, primary, Glorennec, Philippe, additional, Cot, Michel, additional, Dumas, Pierre, additional, Durand, Séverine, additional, Massougbodji, Achille, additional, Ayotte, Pierre, additional, and Le Bot, Barbara, additional
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- 2016
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19. Elevated Blood Lead Levels Are Associated with Reduced Risk of Malaria in Beninese Infants
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Moya-Alvarez, Violeta, primary, Mireku, Michael Osei, additional, Ayotte, Pierre, additional, Cot, Michel, additional, and Bodeau-Livinec, Florence, additional
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- 2016
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20. Impact of Helminth Infection during Pregnancy on Cognitive and Motor Functions of One-Year-Old Children
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Mireku, Michael O., primary, Boivin, Michael J., additional, Davidson, Leslie L., additional, Ouédraogo, Smaïla, additional, Koura, Ghislain K., additional, Alao, Maroufou J., additional, Massougbodji, Achille, additional, Cot, Michel, additional, and Bodeau-Livinec, Florence, additional
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- 2015
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21. Epistatic Interactions between Apolipoprotein E and Hemoglobin S Genes in Regulation of Malaria Parasitemia
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Rougeron, Virginie, primary, Woods, Caira M., additional, Tiedje, Kathryn E., additional, Bodeau-Livinec, Florence, additional, Migot-Nabias, Florence, additional, Deloron, Philippe, additional, Luty, Adrian J. F., additional, Fowkes, Freya J. I., additional, and Day, Karen P., additional
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- 2013
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22. Maternal Anemia in Pregnancy: Assessing the Effect of Routine Preventive Measures in a Malaria-Endemic Area
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Ouédraogo, Smaïla, primary, Accrombessi, Manfred M. K., additional, Bodeau-Livinec, Florence, additional, Koura, Ghislain K., additional, Cot, Michel, additional, and Massougbodji, Achille, additional
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- 2013
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23. Maternal Anemia at First Antenatal Visit: Prevalence and Risk Factors in a Malaria-Endemic Area in Benin
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Ouédraogo, Smaïla, primary, Accrombessi, Manfred M. K., additional, Massougbodji, Achille, additional, Koura, Ghislain K., additional, Bodeau-Livinec, Florence, additional, and Cot, Michel, additional
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- 2012
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24. Maternal Anemia in Benin: Prevalence, Risk Factors, and Association with Low Birth Weight
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Bodeau-Livinec, Florence, primary, Berger, Jacques, additional, Briand, Valerie, additional, Cot, Michel, additional, Day, Karen P., additional, Xiong, Xu, additional, and Massougbodji, Achille, additional
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- 2011
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25. Malaria and gravidity interact to modify maternal haemoglobin concentrations during pregnancy.
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Ou�draogo, Sma�la, Bodeau-Livinec, Florence, Briand, Val�rie, Bich-Tram Huynh, Koura, Ghislain K., Accrombessi, Manfred M. K., Fievet, Nadine, Massougbodji, Achille, Deloron, Philippe, and Cot, Michel
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MALARIA ,HEMOGLOBINS ,PREGNANCY ,ANEMIA ,BLOOD diseases - Abstract
Background: Primigravidity is one of the main risk factors for both malaria and anaemia. Since the implementation of intermittent preventive treatment (IPTp) in sub-Saharan Africa, the relationship between anaemia and gravidity and its evolution during pregnancy has been little explored. This study aimed to evaluate the impact of gravidity on the variation of haemoglobin during pregnancy according to the timing of gestation. Methods: Data from three studies carried out in nearby areas in south Benin (Ouidah, Comé, Allada) between 2005 and 2012 were analysed. At inclusion (first antenatal visit, ANV1) women's age, area of residence, schooling, gravidity, gestational age, weight and height were recorded. Thick blood smears were performed on ANV1, second visit (ANV2) and at delivery. In Allada, women's serum ferritin and CRP concentrations were also assessed. The impact of gravidity on maternal haemoglobin (Hb) was analysed using a logistic or linear regression depending on the outcome. The statistical significance was set to P < 0.05. Results: In total, data from 3,591 pregnant women were analysed. Both univariate and multivariate analyses showed a constant association between Hb concentrations and gravidity in the three periods of Hb assessment (ANV1, ANV2 and delivery). Mean Hb concentration was significantly lower in primigravidae than in multigravidae at ANV1 (mean difference = -2.4 g/L, CI 95%: [-3.4, -1.4], P < 0.001). Afterwards, there was a significant increase in primigravidae only, with a tendency to reversal between primigravidae and multigravidae, which was confirmed at delivery (mean difference = 2.8 g/L, CI 95%: [1.3, 4.2], P < 0.001). The prevalence of malaria infection was halved between ANV1 and delivery in primigravidae while it decreased by only 38% among multigravidae, who were less prone to malaria infection (prevalence at ANV1, 20% and 10% respectively). Iron deficiency was more common in multigravidae, and it decreased slightly in this group between ANV1 and delivery. Conclusion: In a context of IPTp, Hb levels improved progressively throughout pregnancy in primigravidae, likely as a result of reduction in malaria infection. In multigravidae, the improvement was less perceptible and anaemia was mainly due to iron deficiency. [ABSTRACT FROM AUTHOR]
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- 2012
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26. Prenatal iron deficiency, neonatal ferritin, and infant cognitive function
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Mireku, Michael O., Davidson, Leslie L., Boivin, Michael J., Zoumenou, Romeo, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Mireku, Michael O., Davidson, Leslie L., Boivin, Michael J., Zoumenou, Romeo, Massougbodji, Achille, Cot, Michel, and Bodeau-Livinec, Florence
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OBJECTIVE: To investigate the impact of prenatal maternal iron deficiency (ID) on cord blood serum ferritin (CBSF) concentration and infant cognitive and motor development. METHODS: Our prospective cohort study included 636 mother-singleton child pairs from 828 eligible pregnant women who were enrolled during their first antenatal care (ANC) visit in Allada, Benin, into a clinical trial comparing the efficacy of mefloquine and sulfadoxine-pyrimethamine. Venous blood samples of women were assessed for ferritin and hemoglobin concentrations at the first and second ANC visits (occurring at least 1-month apart) and at delivery. Women were prescribed daily iron and folic acid supplements throughout pregnancy. Hematologic examinations were repeated for cord blood at birth. At age 1 year, cognitive and motor functions of children were assessed by using the Mullen Scales of Early Learning. RESULTS: The prevalence of prenatal ID at first and second ANC visits, and at delivery was 30.5%, 34.0%, and 28.4%, respectively. CBSF concentrations were similar between ID and non-ID pregnant women. Neither prenatal ID nor CBSF concentration was associated with poor cognitive or gross motor function of children at age 1 year. CBSF concentrations were lower among mothers who had ID anemia (IDA) at delivery compared with non-IDA pregnant women (adjusted mean difference: –0.2 [95% confidence interval: –0.4 to –0.0]). CONCLUSIONS: In a malaria-endemic region, ID in pregnancy in the context of iron supplementation is neither associated with CBSF concentration nor with infant cognitive and motor development. Prenatal IDA around the time of delivery is associated with lower CBSF concentrations.
27. Consequences of prenatal geophagy for maternal prenatal health, risk of childhood geophagy and child psychomotor development
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Mireku, Michael O., Davidson, Leslie L., Zoumenou, Romeo, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Mireku, Michael O., Davidson, Leslie L., Zoumenou, Romeo, Massougbodji, Achille, Cot, Michel, and Bodeau-Livinec, Florence
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Objective To investigate the relationship between prenatal geophagy, maternal prenatal haematological indices, malaria, helminth infections and cognitive and motor development among offspring. Methods: At least a year after delivery, 552 of 863 HIV-negative mothers with singleton births who completed a clinical trial comparing the efficacy of sulfadoxine-pyrimethamine and mefloquine during pregnancy in Allada, Benin, responded to a nutrition questionnaire including their geophagous habits during pregnancy. During the clinical trial, helminth infection, malaria, haemoglobin and ferritin 3 concentrations were assessed at 1st and 2nd antenatal care visits (ANV) and at delivery. After the first ANV, women were administered daily iron and folic acid supplements until three months postdelivery. Singleton children were assessed for cognitive function at age 1 year using the Mullen Scales of Early Learning. Results: The prevalence of geophagy during pregnancy was 31.9%. Pregnant women reporting geophagy were more likely to be anaemic (AOR = 1.9, 95% CI [1.1, 3.4]) at their first ANV if they reported geophagy at the first trimester. Overall, prenatal geophagy was not associated with maternal haematological indices, malaria or helminth infections, but geophagy during the third trimester and throughout pregnancy was associated with poor motor function (AOR = -3.8, 95% CI [-6.9, -0.6]) and increased odds of geophagous behaviour in early childhood, respectively. Conclusions: Prenatal geophagy is not associated with haematological indices in the presence of micronutrient supplementation. However, it may be associated with poor child motor function and infant geophagy. Geophagy should be screened early in pregnancy.
28. Impact of helminth infection during pregnancy on cognitive and motor functions of one-year-old children
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Mireku, Michael O., Boivin, Michael J., Davidson, Leslie L., Ouédraogo, Smaïla, Koura, Ghislain K., Alao, Maroufou J., Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Mireku, Michael O., Boivin, Michael J., Davidson, Leslie L., Ouédraogo, Smaïla, Koura, Ghislain K., Alao, Maroufou J., Massougbodji, Achille, Cot, Michel, and Bodeau-Livinec, Florence
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Objective To determine the effect of helminth infection during pregnancy on the cognitive and motor functions of one-year-old children. Methods Six hundred and thirty five singletons born to pregnant women enrolled before 29 weeks of gestation in a trial comparing two intermittent preventive treatments for malaria were assessed for cognitive and motor functions using the Mullen Scales of Early Learning, in the TOVI study, at twelve months of age in the district of Allada in Benin. Stool samples of pregnant women were collected at recruitment, second antenatal care (ANC) visit (at least one month after recruitment) and just before delivery, and were tested for helminths using the Kato-Katz technique. All pregnant women were administered a total of 600 mg of mebendazole (100 mg two times daily for 3 days) to be taken after the first ANC visit. The intake was not directly observed. Results Prevalence of helminth infection was 11.5%, 7.5% and 3.0% at first ANC visit, second ANC visit and at delivery, respectively. Children of mothers who were infected with hookworms at the first ANC visit had 4.9 (95% CI: 1.3–8.6) lower mean gross motor scores compared to those whose mothers were not infected with hookworms at the first ANC visit, in the adjusted model. Helminth infection at least once during pregnancy was associated with infant cognitive and gross motor functions after adjusting for maternal education, gravidity, child sex, family possessions, and quality of the home stimulation. Conclusion Helminth infection during pregnancy is associated with poor cognitive and gross motor outcomes in infants. Measures to prevent helminth infection during pregnancy should be reinforced.
29. Soil-transmitted helminth infection in pregnancy and long-term child neurocognitive and behavioral development: A prospective mother-child cohort in Benin
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Garrison, Amanda, Boivin, Michael, Khoshnood, Babak, Courtin, David, Alao, Jules, Mireku, Michael, Ibikounle, Moudachirou, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Garrison, Amanda, Boivin, Michael, Khoshnood, Babak, Courtin, David, Alao, Jules, Mireku, Michael, Ibikounle, Moudachirou, Massougbodji, Achille, Cot, Michel, and Bodeau-Livinec, Florence
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Background An estimated 30% of women in Sub-Saharan Africa suffer from soil-transmitted helminth infection during pregnancy (SHIP), which has been shown to increase risk of pre-term birth, low birth weight, and maternal anemia. A previous study in Benin found that SHIP was associated with impaired cognitive and gross motor development scores in 635 one-year-old children. The objective of the present study was to follow children prospectively to investigate whether the association between SHIP and child neurocognitive and behavioral development persisted at age six. Principal findings Our prospective child cohort included 487 live-born singletons of pregnant women enrolled in the Malaria in Pregnancy Preventive Alternative Drugs clinical trial in Allada, Benin. SHIP was assessed at three antenatal visits (ANVs) through collection and testing of stool samples. Neurocognitive and behavioral development was assessed in six-year-old children by trained investigators using the Kaufman Assessment Battery for Children 2nd edition and the parent-reported Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models generated coefficients and 95% confidence intervals and potential mediating factors were tested. Prevalence of SHIP was 13% at the 1st ANV, 9% at the 2nd ANV, and 1% at delivery. SHIP was not associated with low neurocognitive scores in children at six years. Higher SDQ internalizing scores, indicating increased emotional impairments in children, were associated with helminth infection at the 2nd ANV/delivery 1.07 (95% CI 0.15, 2.00) and at least once during pregnancy 0.79 (95% CI 0.12, 1.46) in adjusted models. Mediation analysis did not reveal significant indirect effects of several mediators on this association. Conclusions Our study shows that while SHIP is not associated with impaired long-term neurocognitive development, infections may have significant negative impacts on emotional development in six-year-old children. SHIP remains a crit
30. Associations between the Strengths and Difficulties Questionnaire (SDQ) and Tests of Variables of Attention (TOVA) in rural school-aged children in Benin Africa.
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Zoumenou R, Costet N, Boivin MJ, Wendland J, and Bodeau-Livinec F
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Sub-Sahara Africa (SSA) children are at high-risk neurodevelopmentally due to the prevalence of infectious disease, nutritional deficiencies and compromised caregiving. However, few mental health screening measures are readily available for general use. The Strengths and Difficulties Questionnaire (SDQ) has been used as a mental health screening measure in the SSA, but its psychometric properties are not well understood. Five hundred and sixty-six mothers completed the SDQ for their 6-year-old children in rural Benin north of Cotonou. These were mothers who had been part of a malarial and intestinal parasite treatment program and micronutrient fortification intervention program during pregnancy for these children. Their study children ( N = 519) completed the computerized Tests of Variables of Attention (TOVA-visual) as a performance-based screening assessment of attention deficit and hyperactivity disorders. In evaluating the relationship between the SDQ and TOVA, we controlled for maternal risk factors such as depression, poor socioeconomic status and educational level, along with the child's schooling status. TOVA measures of impulsivity were significantly related to SDQ emotional and hyperactivity/inattention difficulties. TOVA inattention was related to SDQ emotional difficulties. The triangulation of maternal risk factors (e.g., depression), the SDQ and the TOVA can provide effective screening for mental health issues in SSA children., Competing Interests: The authors declare no conflict of interest., (© The Author(s) 2025.)
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- 2025
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