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2. Outcomes of Micropulse Laser Trabeculoplasty Compared to Selective Laser Trabeculoplasty: A Systematic Review and Meta-Analysis

Author

Zhu D, Shah PP, Zhang C, Wong A, Bouaziz M, Barmas-Alamdari D, Mootz J, Yu A, Tirsi A, and Tello C

Subjects
trabeculoplasty, micropulse, slt, selective laser trabeculoplasty, glaucoma, Ophthalmology, RE1-994
Abstract

Daniel Zhu,1,2,&ast; Paras P Shah,1,2,&ast; Charles Zhang,3 Amanda Wong,4 Michael Bouaziz,1,2 Daniel Barmas-Alamdari,1,2 Joseph Mootz,1,2 Austin Yu,5 Andrew Tirsi,1,2 Celso Tello1,2 1Department of Ophthalmology, Northwell Health Eye Institute, Great Neck, New York, 11021, USA; 2Manhattan Eye, Ear, & Throat Hospital, New York, New York, 10065, USA; 3Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY, 14203, USA; 4Department of Ophthalmology, New York Eye and Ear Infirmary, New York, New York, 10003, USA; 5Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, 19129, USA&ast;These authors contributed equally to this workCorrespondence: Daniel Zhu, Department of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 600 Northern Blvd., Suite 214, Great Neck, NY, 11021, USA, Email dzhu@northwell.eduPurpose: To perform a meta-analysis and systematic review to compare the efficacy and complications of micropulse laser trabeculoplasty (MLT) and selective laser trabeculoplasty (SLT) in adult patients with open-angle glaucoma (OAG) and ocular hypertension (OHT).Methods: We performed a systematic review utilizing PubMed, Embase, and Scopus, on April 8, 2024. Meta-analyses were performed for the mean change in intraocular pressure (IOP) at one-month, six-month, and one-year follow-up visits, rate of IOP spikes (> 5 mmHg increase from the pre-procedure baseline IOP), rate of treatment failure (< 20% or < 3 mmHg reduction in IOP or requiring additional medications or procedures), and mean change in number of medications.Results: Six studies, with a total of 593 eyes, were included: 283 underwent MLT, while 310 underwent SLT. A statistically significant difference in the efficacy of MLT versus SLT at one-month and six-month follow-ups was present, with SLT reducing IOP by 0.83 mmHg (95% CI: 0.20, 1.47; P = 0.01) more and 0.55 mmHg (95% CI: 0.02, 1.08; P = 0.04) more than MLT, respectively. At the one-year follow-up, there was no significant disparity in IOP reduction between SLT and MLT (WMD = 0.16; 95% CI: − 0.40, 0.71; P = 0.58). There was a significantly lower rate of IOP spikes in the MLT treatment group (RR = 0.37; 95% CI: 0.16, 0.89; P = 0.03). There was no statistically significant difference in the rate of treatment failures (RR = 1.05; 95% CI: 0.68, 1.62; P = 0.84) or number of topical medications reduced (WMD = 0.06; 95% CI: − 0.13, 0.26; P = 0.53).Conclusion: While SLT may offer greater short-term reductions in IOP, it may be associated with more postoperative IOP spikes when compared to MLT. At one-year follow-up, there were no significant differences in IOP reduction or failure rates between the MLT and SLT groups.Keywords: trabeculoplasty, micropulse, SLT, selective laser trabeculoplasty, glaucoma

Published
2024

6. Novel polyethersulfone mixed matrix adsorptive nanofiltration membrane fabricated from embedding zinc oxide coated by polyaniline

Author

Erragued, R., Sharma, M., Costa, Carolina, Bouaziz, M., Gando-Ferreira, L. M., Erragued, R., Sharma, M., Costa, Carolina, Bouaziz, M., and Gando-Ferreira, L. M.

Abstract

Novel mixed matrix polymeric membranes were prepared by incorporating self-produced zinc oxide coated by polyaniline (ZnO-PANI) nanoparticles into polyethersulfone (PES) matrix using phase inversion method. Nanoparticles were synthesized, characterized and incorporated in PES matrix with loadings from 0.05 to 0.6 wt%. ZnO-PANI demonstrated effectiveness as a low-cost adsorbent, especially at a loading of 0.2 wt%. ZnO-PANI was used for adsorbing total phenolic compounds (TPC) from olive leaf extract (OLE) at different initial adsorbate concentration (49.92–466.59 mg/L) and pH (2−6). ZnO-PANI proved to be an effective and low-cost adsorbent to remove TPC from OLE. Langmuir model described the adsorption of TPC better than Freundlich model. Effect of incorporated nanoparticles on membranes morphology and hydrophilic properties studied using contact angle measurement, water content, membrane pore size and porosity, SEM, FTIR and pure water flux. Prepared membranes showed a significant increment in porosity, pore size and hydrophilicity by addition of ZnO-PANI in the casting solution up to 0.2 wt%. This led to a considerable improvement in permeability, which decreased with higher additive concentration. During OLE filtration tests (10–30 bar) using bare PES and 0.2 wt% ZnO-PANI/PES membranes, 0.2 wt% ZnO-PANI/PES showed the highest permeate flux and good TPC rejection (83–87%). Bare PES exhibited impressive TPC value rejections (85–92%) and better fouling resistance. Using 0.2 wt% ZnO-PANI achieved a balanced permeate flux and TPC rejection. The research emphasizes the practical applicability of these membranes in various industries due to their enhanced efficacy in removing phenolic compounds from natural extracts, offering a balanced approach between permeate flux and TPC rejection.

Published
2023
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14. Location Optimization of a Hydraulic Turbine for Koudiet Acerdoune Water Treatment Plants

Author

Algérienne des eaux, IGUERCHA, Amina, ZOUAOUI, Salah, MOHAMMEDI, Kamal, BOUAZIZ, M., KARI, D., Algérienne des eaux, IGUERCHA, Amina, ZOUAOUI, Salah, MOHAMMEDI, Kamal, BOUAZIZ, M., and KARI, D.

Abstract

This study aims to recover the residual energy of the water in the water treatment plant using turbines instead of wasting energy in the dissipator as it is currently done by means of load- breaker valves. Analysis of the technical efficiency of the project and an assessment of the hydroelectric potential available were carried out and different options for the installation of turbines were proposed. The estimated maximum amount of energy that can be recovered is around 7.44 GWh, and the maximum amount of carbon emissions saved are 446.210 tons. The evaluation of the profitability of our project integrating an energy recovery device is fair., Cette étude vise à récupérer l'énergie résiduelle de l’eau à son arrivée dans la station de traitement d'eau par turbinage, au lieu de continuer à la dissiper comme on le fait actuellement au moyen de robinets brises-charge. Une analyse de la faisabilité technique du projet et une évaluation du potentiel hydroélectrique disponible ont été accomplies, avant de proposer différentes options pour l’installation des équipements de turbinage. En utilisant cette méthode, le maximum de quantité d'énergie qui peut être récupérée a été estimée à 7,44 GWh, celui de la quantité de carbone économisée a été estimé à 446,210 tonnes CO2. Nous concluons notre projet par une évaluation de la rentabilité des aménagements hydroélectriques.

Published
2022

15. PB2304: THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP): A SINGLE-CENTER EXPERIENCE

Author

Kammoun, F., primary, Fakhfakh, Y., additional, Charfi, M., additional, Kassar, O., additional, Chaari, M., additional, Bouaoun, L., additional, Bahloul, M., additional, Frikha, I., additional, Kallel, F., additional, Ben Amor, I., additional, Khalifa, L., additional, Medhafar, M., additional, Hadiji, S., additional, Elleuch, H., additional, Mnif, H., additional, Bouaziz, M., additional, and Elloumi, M., additional

Published
2022
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19. Calibration of a Microscopic Measurement System by Projection Technique of Coded Periodic Patterns.

Author

Bouali, H., Belkacemi, Y., Bouaziz, M., and Mansouri, K.

Subjects
DIGITAL cameras, CALIBRATION, CAMERA calibration, ERROR rates, MEASUREMENT
Abstract

The measurement based on the vision of periodic patterns by a remote camera is a more suitable solution for the control and characterization of micro robotic systems. In this way, we can take precise measurements without disturbing the measured objects and without the need for more devices and sensors that cause great confusion and clutter around the workspace. The technique of projection of the coded periodic patterns is perhaps effective and of good performance and especially in the case of a well calibrated system. Indeed, the question arises on the influence of the calibration on the results of measurement by this technique in terms of precision and uncertainty. Thus, the main purpose of this article is to study the influence of calibration on the measurement process, by deducing and calculating the committed error and the uncertainty rate. Based on an algorithm in MATLAB, we first create a coded periodic test pattern to which we apply a certain imposed displacement. Then, we project this pattern using a projection and reduction system on a digital camera which captures a photo and transmits it to a processing algorithm, which, in turn, calculates and deduces a value for the measured displacement. The repetition of this process occurs several times on the same imposed displacement (the same standard) to provide us with several measured values, this redundancy of the data allows us to draw a calibration curve and deduce several metrological parameters from our system of measure. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Evidence of the Contribution of the X Chromosome to Systemic Sclerosis Susceptibility: Association With the Functional Irak1 196Phe/532Ser Haplotype

Author

Dieudé, P., Bouaziz, M., Guedj, M., Riemekasten, G., Airò, P., Müller, M., Cusi, D., Matucci-Cerinic, M., Melchers, I., Koenig, W., Salvi, E., Wichmann, H. E., Cuomo, G., Hachulla, E., Diot, E., Hunzelmann, N., Caramaschi, P., Mouthon, L., Riccieri, V., Distler, J., Tarner, I., Avouac, J., Meyer, O., Kahan, A., Chiocchia, G., Boileau, C., and Allanore, Y.

Published
2011
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23. Effect of Pollution on the Quality of Olive Oils from Trees Grown Near a Phosphoric Acid Factory

Author

Ministère de l'Enseignement Supérieur et de la Recherche Scientifique (Algerie), Rekik, O., Ben Mansour, A., Jabeur, H., Rodríguez-Gutiérrez, Guillermo, Bouaziz, M., Ministère de l'Enseignement Supérieur et de la Recherche Scientifique (Algerie), Rekik, O., Ben Mansour, A., Jabeur, H., Rodríguez-Gutiérrez, Guillermo, and Bouaziz, M.

Abstract

Given the importance of olive oil as a food product worldwide and given the exposure of many productive olive orchards to many pollution sources, this work is a contribution to the clarification of atmospheric metal pollution effects on the quality of olive oil and its possible toxicity for human beings. This work is carried out on olive orchards (Olea europaea L., cv. Chemlali) situated in a polluted region close to a fertilizer factory and in a controlled, unpolluted area, managed with comparable cultivation techniques during two successive years (2015/2016 and 2016/2017). Pollution negatively affects the oxidative stability and nutritional value of olive oil, especially by decreasing the contents of antioxidant compounds and the fatty acid composition. Atmospheric metals are confirmed to have a negative effect on olive oil chemicals; oils show a disruption of their squalene, tocopherols, and triglyceride composition in comparison with control oils. Practical Applications: This study is carried out in two olive orchards (Olea europaea L., cv. Chemlali) located in a polluted area near a fertilizer factory and in a control unpolluted site, managed with similar cultivation techniques. The aim is to investigate the physiological and biochemical responses of polluted oils (PO), exposed to atmospheric metal contamination as compared to control oils (CO). The results of this study emanate from the accidental exposure to contamination sources, such as the direct contact of olives, with an elevated polluted environment that might be made more severe by gaseous air pollutants emitted by the factory. Then, air contamination avoidance from factories should be examined together with any possible probable methodologies to decrease plant tissue contamination. The SIAPE is the main pollution source in Sfax city. Vegetation developed around the city is continuously exposed to air pollution. Therefore, olive fruits are contaminated by the chemical pollution which affects the qualit

Published
2019

25. Bizarre Parosteal Osteochondromatous Proliferation: Nora's Lesion

Author

Chaabane, S., Chelli Bouaziz, M., Ben Ghars, K. H., Abid, L., Jaafoura, M. H., and Ladeb, M. F.

Subjects
Radiography, Musculoskeletal Imaging, Ultrasound, Parosteal Osteochondroma, Bone, CT, MRI
Abstract

The purpose of this study was to review the imaging and anatomopathologic findings and to discuss the main differential diagnosis of bizarre parosteal osteochondromatous proliferation (BPOP) or Nora's lesion, a rare benign surface lesion of the bone. Histologically confirmed plain radiographs, ultrasound, CT and MRI images of four patients with BPOP were obtained and retrospectively reviewed. Three cases involving the hand and one involving the foot are reported. On plain radiographs, BPOP is a wellmarginated, calcified or ossified mass arising directly from the cortical surface of the underlying bone. Ultrasound images show a low echoic peripheral cap around the lesion. CT images show the wide base of the lesion. On MRI, BPOP was of a low signal on T1, enhancing following gadolinium administration. Underlying bone and adjacent surrounding soft tissues were normal.

Published
2011

26. A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis

Author

Koumakis, E., Bouaziz, M., Dieude, P., Cauvet, A., Ruiz, B., Airo, P., Cusi, D., Matucci-Cerinic, M., Salvi, E., Cuome, G., Hachulla, E., Diot, E., Caramaschi, P., Valeria RICCIERI, Avouac, J., Allanore, Y., Université Sorbonne Paris Cité (USPC), Departement A de Rhumatologie, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Statistique et Génome (SG), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques et Modélisation d'Evry, Université d'Evry Val d'Essonne, Departement de Rhumatologie, Hôpital Bichat - Claude Bernard, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Diderot - Paris 7 (UPD7), UMR 699 Service de Rhumatologie, Institut National de la Santé et de la Recherche Médicale (INSERM), Reumatologia e Immunologia, Spedali Civil Brescia, Biomedical Laboratory Techniques, Università degli Studi di Milano [Milano] (UNIMI), Department of Experimental and Clinical Medicine, Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), Department of Health Science, Università del Molise, Department of Internal Medicine, Huntsman Cancer Institute, Hôpital Claude Huriez [Lille], CHU Lille, IFR 618 Service de Pneumologie, Hôpital Bretonneau, Assistance Publique - Hôpitaux de Paris (AP-HP), Unità di Reumatologia, Azienda Ospedaliera, University of Verona (UNIVR), Dipartimento di Medicina Interna e Specialitá Mediche, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Koumakis, Eugenie, Bouaziz, Matthieu, Dieudé, Philippe, Cauvet, Anne, Ruiz, Barbara, Airò, Paolo, Cusi, Daniele, Matucci Cerinic, Marco, Salvi, Erika, Cuomo, Giovanna, Hachulla, Eric, Diot, Elisabeth, Caramaschi, Paola, Riccieri, Valeria, Avouac, Jerome, Allanore, Yannick, Université Sorbonne Paris Cité ( USPC ), CHU Cochin [AP-HP], Université Paris Descartes - Paris 5 ( UPD5 ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Statistique et Génome ( SG ), Institut National de la Recherche Agronomique ( INRA ) -Université d'Évry-Val-d'Essonne ( UEVE ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Mathématiques et Modélisation d'Evry ( LaMME ), Institut National de la Recherche Agronomique ( INRA ) -Université d'Évry-Val-d'Essonne ( UEVE ) -ENSIIE-Centre National de la Recherche Scientifique ( CNRS ), Hôpital Bichat - Claude Bernard, Assistance Publique - Hôpitaux de Paris ( AP-HP ), Université Paris Diderot (Paris 7), Institut National de la Santé et de la Recherche Médicale ( INSERM ), Universita degli Studi di Milano ( UNIMI ), University 'Magna Græcia', Hôpital Claude Huriez, Hôpital Bretonneau, Assistance Publique - Hôpitaux de Paris ( AP-HP ), Università degli Studi di Verona, Università degli Studi di Roma 'La Sapienza', Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques et Modélisation d'Evry (LaMME), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-ENSIIE-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Milano [Milano], Università degli Studi di Roma 'La Sapienza' [Rome], Université d'Évry-Val-d'Essonne (UEVE), Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Università degli Studi del Molise = University of Molise (UNIMOL), Università degli studi di Verona = University of Verona (UNIVR), and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)

Subjects
Adult, Genetic Markers, Male, systemic sclerosis, [SDV]Life Sciences [q-bio], CD2 Antigens, Polymorphism, Single Nucleotide, White People, polymorphism, sclérose, polymorphisme génétique, Gene Frequency, Risk Factors, sclerosis, autoimmunité, Odds Ratio, Humans, genetic polymorphism, Genetic Predisposition to Disease, genetics, skin and connective tissue diseases, Genetic Association Studies, Aged, Scleroderma, Systemic, [ SDV ] Life Sciences [q-bio], integumentary system, autoimmunity, Middle Aged, CD2, Phenotype, Haplotypes, Italy, Case-Control Studies, Female, France
Abstract

Systemic sclerosis (SSc) is a rare autoimmune disease (AID) with a complex genetic etiology. Evidence for a shared pathogenesis across AIDs is given by the well-known pleiotropism of autoimmune genes. Recently, several unbiased approaches have identified an association between polymorphisms of the CD2 gene, and rheumatoid arthritis (RA) susceptibility. The objective of this study was to investigate whether CD2 polymorphisms are associated with SSc. Objective. Systemic sclerosis (SSc) is a rare autoimmune disease (AID) with a complex genetic aetiology. Evidence for a shared pathogenesis across AIDs is given by the well-known pleiotropism of autoimmune genes. Recently, several unbiased approaches have identified an association between polymorphisms of the CD2 gene, and rheumatoid arthritis (RA) susceptibility. The objective of this study was to investigate whether CD2 polymorphisms are associated with SSc.Methods. Two SNPs of CD2, rs624988 and rs798036, were genotyped in a total of 1,786 SSc patients and 2,360 healthy individuals from two European populations (France and Italy). Meta analyses were performed to assess whether an association exists between CD2 polymorphisms or haplotypes and SSc or its main subtypes.Results. The combined analyses revealed an association between the rs624988 A allele and SSc susceptibility: p(adj)=0.023, OR=1.14 (95%CI 1.04-1.25). Single marker analysis did not reveal any association between rs798036 and SSc. Haplotype analysis identified that the A-T haplotype, previously described in RA, was associated with higher susceptibility for SSc (p(adj)=0.029, OR=1.14, 95%CI 1.04-1.25) and with the positive anticentromere antibody sub-group of SSc patients (p(adj)=0.009, OR=1 95%CI 1.07-1.32). Genotype-mRNA expression correlations revealed that the CD2 risk haplotype was associated with decreased CD2 mRNA expression in SSc patients.Conclusion. Our study establishes CD2 as a new susceptibility factor for SSc, in a European Caucasian population, confirming the sharing of autoimmune risk factors by SSc and RA.

Published
2016

27. Thermal Performance Enhancement of a Shallow Solar Pond Based on Nanofluids.

Author

Terfai, A., Chiba, Y., and Bouaziz, M. N.

Subjects
NANOFLUIDS, SOLAR ponds, THERMOPHYSICAL properties, THERMAL insulation, RADIATION absorption, INSULATING materials
Abstract

In this work, the thermal performance enhancement of a shallow solar pond (SSP) was verified theoretically. The SSP operates under the open cycle to extract heat in order to increase own efficiency. SSP was provided with two transparent glass covers to reduce heat loss and increase global warming. It was also coated with a heat insulation material; the bottom of the SSP is painted in black to improve the absorption of solar radiation. In order to enhance heat extraction, five types of nanofluids with different physical properties were passed through a heat exchanger in the form of a serpentine welded to the bottom of the SSP. Five types of metal nanoparticles such as Al2O3, CuO, TiO2, SiO2, and Cu were mixed with pure water under various concentrations ranging from 0 to 5 % to obtain the nanofluids. A numerical model was developed based on the solution of thermal balance equations after discretization by using real meteorological conditions of the Medea city located in Algeria. The simulation was conducted on June 8 from 5 am to 6 am hours for the next day. The obtained results, including thermophysical properties, temperature of the pond and exergy performance, were presented and discussed. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Investigation of physicochemical, nutritional, textural, and sensory properties of yoghurt fortified with fresh and dried Spirulina (Arthrospira platensis).

Author

Bchir, B., Felfoul, I., Bouaziz, M. A., Gharred, T., Yaich, H., Noumi, E., Snoussi, M., Bejaoui, H., Kenzali, Y., Blecker, C., and Attia, H.

Subjects
YOGURT, SPIRULINA, PRINCIPAL components analysis, STREPTOCOCCUS thermophilus, INVESTIGATIONS
Abstract

The present work investigated the effect of incorporating fresh spirulina as compared to dried spirulina into yoghurt, at three different concentrations (0.1%, 0.3% and 0.5%). The samples were analysed to determine the physicochemical, rheological and sensory properties, and viability of Streptococcus thermophilus during storage. Interrelationships between the parameters were investigated using the principal component analysis. Supplementing yoghurt with both spirulina forms increased the protein content, acidity, and apparent viscosity, and lessened the syneresis rate. The supplementation of fresh spirulina slightly reduced the viability of bacterium during the storage. Yoghurts fortified with fresh spirulina yielded different colour parameters, a low amount of protein, ash, and viscosity as compared to yoghurt supplemented with dried spirulina. Grouping the variables in the principal component analysis plot indicated that each yoghurt has specific characteristics. Panellists appreciated the yoghurt that was enriched with 0.3% of fresh spirulina more than other formulations and attributed the lowest score to appearance. Overall, it can be concluded that untreated spirulina can be exploited as a natural ingredient to develop novel yoghurt with high nutritional properties. [ABSTRACT FROM AUTHOR]

Published
2019

29. A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis

Author

Koumakis, E., Bouaziz, M., Dieude, P., Ruiz, B., Riemekasten, G., Airo, P., Muller Nurasyid, M., Cusi, D., Matucci Cerinic, M., Melchers, I., Salvi, E., Strauch, K., Peters, A., Cuomo, G., Hachulla, E., Diot, E., Hunzelmann, N., Caramaschi, P., Riccieri, Valeria, Distler, J. H., Tarner, I., Avouac, J., Letenneur, L., Amouyel, P., Lambert, J. C., Chiocchia, G., Boileau, C., Allanore, Y., Institut Cochin (IC UM3 (UMR 8104 / U1016)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1152 Statistique et Génome, Institut National de la Recherche Agronomique (INRA), U699, Institut National de la Santé et de la Recherche Médicale (INSERM), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Leibniz Association, Civil Hospital, Ludwig Maximilians University of Munich, Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), University Hospital, Università degli Studi di Milano [Milano] (UNIMI), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), University of Freiburg [Freiburg], Munich Heart Alliance, Munich, Germany, Partenaires INRAE, Helmholtz-Zentrum München (HZM), Università degli studi di Napoli Federico II, Université de Lille, Droit et Santé, University of Cologne, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Justus-Liebig-Universität Gießen (JLU), Kerckhoff clinic, U 897, Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Université Paris Descartes - Paris 5 (UPD5), Hôpital Ambroise Paré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Actelion, Bayer, GlaxoSmithKline, Bristol-Myers Squibb, UCB, Celgene, JB Therapeutics, Boehringer Ingelheim, Novartis, RuiYi, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Statistique et Génome (SG), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Ludwig-Maximilians University [Munich] (LMU), Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi di Firenze = University of Florence (UniFI), Helmholtz Zentrum München = German Research Center for Environmental Health, University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Koumakis, E, Bouaziz, M, Dieudé, P, Ruiz, B, Riemekasten, G, Airo, P, Müller Nurasyid, M, Cusi, D, Matucci Cerinic, M, Melchers, I, Salvi, E, Strauch, K, Peters, A, Cuomo, Giovanna, Hachulla, E, Diot, E, Hunzelmann, N, Caramaschi, P, Riccieri, V, Distler, Jh, Tarner, I, Avouac, J, Letenneur, L, Amouyel, P, Lambert, Jc, Chiocchia, G, Boileau, C, and Allanore, Y.

Subjects
Adult, Male, Receptors, CCR6, Scleroderma, Systemic, antitopoisomerase, Genotype, [SDV]Life Sciences [q-bio], Polymorphism, Single Nucleotide, autoantibodies, genetic regulatory variant, systemic sclerosis, White People, Systemic sclerosi, Humans, Female, Genetic Predisposition to Disease, Alleles, DNA Topoisomerases, Genetic Association Studies, Autoantibodies
Abstract

International audience; Objective: Recognition of the well-known pleiotropism of autoimmune genes supports the concept of a shared pathogenesis across autoimmune diseases such as rheumatoid arthritis (RA) and systemic sclerosis (SSc). Studies have reproducibly demonstrated an association between susceptibility to RA and polymorphisms of the CCR6 gene, a surface marker for Th17 cells, and the causal variant was recently identified. The present study was thus undertaken to investigate whether CCR6 polymorphisms could also be associated with susceptibility to SSc. Methods: Twelve tag single-nucleotide polymorphisms (SNPs) of CCR6, including the known RA-associated SNP rs3093023, were genotyped in a total of 2,411 SSc patients and 7,084 healthy individuals from 3 European populations (France, Italy, and Germany). Meta-analyses of the data were performed to assess whether an association exists between CCR6 polymorphisms and susceptibility to SSc or its main subtypes. Direct sequencing of DNA was performed to ascertain whether the functional dinucleotide polymorphism of CCR6 previously identified in RA (CCR6DNP) was also present in SSc. Results: Combined analyses revealed an association between the rs10946216 SNP and SSc susceptibility (odds ratio [OR] 1.13, 95% confidence interval [95% CI] 1.05-1.21, adjusted P [P-adj] = 0.026). The rs3093023 A allele and rs10946216 T allele were in high linkage disequilibrium, and both were found to confer disease susceptibility in the antitopoisomerase-positive subset of SSc patients (OR 1.27, 95% CI 1.13-1.42, P-adj = 1.5 x 10(-3) and OR 1.32, 95% CI 1.17-1.48, P-adj = 9.0 x 10(-5), respectively, relative to healthy controls). Direct sequencing of the DNA of 78 individuals supported the hypothesis that the regulatory dinucleotide CCR6DNP could be the causal variant in SSc. Conclusion: The results of this study establish CCR6 as a new susceptibility factor for antitopoisomerase-positive SSc, as demonstrated in 3 European Caucasian populations, confirming the notion that SSc and RA could conceivably share autoimmune risk alleles. The results also suggest a potential role of the interleukin-17 pathway in SSc.

Published
2013
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30. Evidence for the contribution of the X chromosome to Systemic Sclerosis susceptibility: Association with the functional IRAK1 196Phe/532Ser haplotype

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DIEUDÉ P, BOUAZIZ M, GUEDJ M, RIEMEKASTEN G, AIRO P, MÜLLER M, CUSI D, MATUCCI, CERINIC M, MELCHERS I, KOENIG W, SALVI E, WICHMANN H, HACHULLA E, DIOT, E, HUNZELMANN N, CARAMASCHI P, MOUTHON L, RICCIERI V, DISTLER J, TARNER I, AVOUAC, J, MEYER O, KAHAN A, CHIOCCHIA G, BOILEAU C, ALLANORE Y., CUOMO, Giovanna, Dieudé, P, Bouaziz, M, Guedj, M, Riemekasten, G, Airo, P, Müller, M, Cusi, D, Matucci, Cerinic, M, Melchers, I, Koenig, W, Salvi, E, Wichmann, H, Cuomo, Giovanna, Hachulla, E, Diot, E, Hunzelmann, N, Caramaschi, P, Mouthon, L, Riccieri, V, Distler, J, Tarner, I, Avouac, J, Meyer, O, Kahan, A, Chiocchia, G, Boileau, C, Allanore, Y., INSERM U699, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Statistique et Génome (SG), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Spedali Civili, Ludwig Maximilians University of Munich, University Hospital, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Università degli Studi di Milano [Milano] (UNIMI), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), University Medical Center, Universität Ulm - Ulm University [Ulm, Allemagne], Department of Cardio-Thoracic and Respiratory Science, Second University of Naples, Naples, Italy, Université de Lille, Droit et Santé, Centre Hospitalier Régional Universitaire de Tours (CHRU de Tours), University of Cologne, Azienda Ospedaliera Universitaria Integrata, Université Paris Descartes - Paris 5 (UPD5), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Justus-Liebig-Universität Gießen (JLU), Université Paris Diderot - Paris 7 (UPD7), Inserm U1016, Paris Descartes University, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Ambroise Paré [AP-HP], Supported by the Agence Nationale de la Recherche (grant R070994KS), the Societe Francaise de Rhumatologie, the Association des Sclerodermiques de France, the Groupe Francais de Recherche sur la Sclerodermie, and INSERM. Unrestricted institutional support was provided by Pfizer. The German Network for Systemic Sclerosis was funded by the German Federal Ministry for Education and Research (grants 01 GM 0310 and 01 GM 0634 to Drs. Riemekasten, Melchers, Hunzelmann, and Tarner). The MONICA/KORA Augsburg studies were funded by the Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg, Germany, with additional support provided by the German Federal Ministry of Education and Research, the German National Genome Research Network (NGFNPlus project, grant 01GS0834), the University of Ulm, and Ludwig-Maximilian University Munich (LMU innovative project, Munich Center of Health Sciences). The European Network for Genetic-Epidemiological Studies (HYPERGENES) was funded by the European Union (Seventh Framework Programme, HEALTH-F4-2007-201550). The sample analyzed in the present study was collected by the Milan group in collaboration with the Center of Transfusion Medicine, Cellular Therapy and Cryobiology, Foundation IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, and the Filarete Foundation.Dr. Distler has received consulting fees, speaking fees, and/or honoraria from Actelion, GlaxoSmithKline, BSP Pharma, and Celgene (less than $10,000 each)., Ludwig-Maximilians University [Munich] (LMU), Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi di Firenze = University of Florence (UniFI), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), and Justus-Liebig-Universität Gießen = Justus Liebig University (JLU)

Subjects
Adult, systemic sclerosis, genotype, Immunology, rheumatology, Biology, iraki haplotype, IRAK1 Haplotype, 03 medical and health sciences, 0302 clinical medicine, Germany, Genotype, Immunology and Allergy, Humans, genetics, Pharmacology (medical), Genetic Predisposition to Disease, interleukin-1 receptor-associated kinases, scleroderma, [INFO]Computer Science [cs], Allele, [MATH]Mathematics [math], skin and connective tissue diseases, X chromosome, 030304 developmental biology, Aged, 030203 arthritis & rheumatology, 0303 health sciences, Chromosomes, Human, X, Scleroderma, Systemic, Genetic heterogeneity, Haplotype, x chromosome, Genetic Variation, Odds ratio, Middle Aged, Confidence interval, IRAK1 protein, human, genetic risk-factor, nf-kappa-b, lupus-erythematosus, innate-immunity, disease, activation, variant, irf5, pathogenesis, 3. Good health, Xq28, Haplotypes, Italy, Case-Control Studies, Female, France
Abstract

Objective Several autoimmune disorders, including systemic sclerosis (SSc), are characterized by a strong sex bias. To date, it is not known whether genes on the sex chromosomes influence SSc susceptibility. Recently, an IRAK1 haplotype that contains the 196Phe functional variant (rs1059702), located on Xq28, was found to confer susceptibility to systemic lupus erythematosus (SLE). This study was undertaken to test for an association between SSc and the IRAK1 SLE risk haplotype. Methods We tested for an association with the IRAK1 SLE risk haplotype in a discovery set of 849 SSc patients and 625 controls. IRAK1 rs1059702 was further genotyped in a replication set, which included Caucasian women from Italy (493 SSc patients and 509 controls) and Germany (466 SSc patients and 1,083 controls). Results An association between the IRAK1 haplotype and SSc was detected in the discovery set. In both the discovery and replication sets, the rs1059702 TT genotype was found to be associated with specific SSc subsets, highlighting a potential contribution to disease severity. A meta-analysis provided evidence of an association of both the T allele and TT genotype with the overall disease, with an odds ratio (OR) of 1.20 and 95% confidence interval (95% CI) of 1.06–1.35 for the T allele (P = 0.003) and an OR of 1.49 and 95% CI of 1.06–2.10 for the TT genotype (P = 0.023). However, the most notable associations were observed with the diffuse cutaneous, anti–topoisomerase I antibody positive, and SSc-related fibrosing alveolitis subsets (OR 2.35 [95% CI 1.51–3.66], P = 1.56 × 10−4, OR 2.84 [95% CI 1.87–4.32], P = 1.07 × 10−6, and OR 2.09 [95% CI 1.35–3.24], P = 9.05 × 10−4, respectively). Conclusion Our study provides the first evidence of an association between IRAK1 and SSc, demonstrating that a sex chromosome gene directly influences SSc susceptibility and its phenotypic heterogeneity.

Published
2011
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32. French Intensive Care Society, International congress - Réanimation 2016

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Jaillette, E, Girault, C, Brunin, G, Zerimech, F, Chiche, A, Broucqsault Dedrie, C, Fayolle, C, Minacori, F, Alves, I, Barrailler, S, Robriquet, L, Delaporte, E, Thellier, D, Delcourte, C, Duhamel, A, Nseir, S, Valette, X, Desmeulles, I, Savary, B, Masson, R, Seguin, A, Daubin, C, Sauneuf, B, Verrier, P, Pottier, V, Orabona, M, Samba, D, Viquesnel, G, Lermuzeaux, M, Hazera, P, Hanouz, J, Parienti, J, Du Cheyron, D, Demoule, A, Clavel, M, Rolland Debord, C, Perbet, S, Terzi, N, Kouatchet, A, Wallet, F, Roze, H, Vargas, F, Guérin, C, Dellamonica, J, Jaber, S, Similowski, T, Quenot, J, Binquet, C, Vinsonneau, C, Barbar, S, Vinault, S, Deckert, V, Lemaire, S, Hssain, A, Bruyère, R, Souweine, B, Lagrost, L, Adrie, C, Jung, B, Daurat, A, De Jong, A, Chanques, G, Mahul, M, Monnin, M, Molinari, N, Lheureux, O, Trepo, E, Hites, M, Cotton, F, Wolff, F, Surin, R, Créteur, J, Vincent, J, Gustot, T, Jacobs, F, Taccone, F, Neuville, M, Timsit, J, El Helali, N, Le Monnier, A, Magalhaes, E, Radjou, A, Smonig, R, Soubirou, J, Voiriot, G, Sonneville, R, Bouadma, L, Mourvillier, B, Gélisse, E, Brasseur, A, Roisin, S, De Backer, D, Van Ruychevelt, V, Carlier, E, Piagnerelli, M, Vanhaeverbeek, M, Danguy, C, Biston, P, Au, S, Begot, E, Dalmay, F, Repessé, X, Prat, G, Bouferrache, K, Slama, M, Vieillard Baron, A, Monnet, X, Marik, P, Teboul, J, Jozwiak, M, Richard, C, Chauvet, J, El Dash, S, Delastre, O, Bouffandeau, B, Jusserand, D, Michot, J, Bauer, F, Brazier, F, Mercado, P, Kontar, L, Titeca, D, De Cagny, B, Bacari Risal, G, Riviere, A, Maizel, J, Guillot, C, Le Reun, C, Lampin, M, Sadik, A, Botte, A, Leteurtre, S, Collins, A, Kempeneers, C, Cajgfinger, N, Ohlmann, C, Pouyau, R, Subtil, F, Baudin, F, Massenavette, B, Javouhey, E, Milesi, C, Essouri, S, Liet, J, Afanetti, M, Durand, S, Durand, P, Roze, J, Dupont, D, Cambonie, G, Soyer, B, Rusca, M, Lukaszewicz, A, Crassard, I, Guichard, J, Bresson, D, de la Garanderie, D, Cantier, M, Sabben, C, Louedec, L, Delbosc, S, Journé, C, Ou, P, Klein, I, Chau, F, Lefort, A, Desilles, J, Michel, J, Mazighi, M, Salem, O, Demeret, S, Bolgert, F, Sharshar, T, Grabli, D, Arib, S, Crippa, I, Soummer, A, Engrand, N, Guedin, P, Aldea, S, Cerf, C, Desailly, V, Pasquier, P, Brun, P, Roux, D, Latournerie, G, Kasprzyk, L, Grosjean, V, Latreche, A, Habert, P, Huot, S, Jobin, T, Tesnière, A, Dreyfuss, D, Ricard, J, Mignon, A, Gaudry, S, Laithier, F, Kimmoun, A, Chouihed, T, Albizzati, S, Camenzind, E, Vanhuyse, F, Levy, B, Cour, M, Venet, F, Hernu, R, Demaret, J, Monneret, G, Argaud, L, Dumas, F, Lamhaut, L, Rosencher, J, Pène, F, Varenne, O, Carli, P, Jouven, X, Spaulding, C, Cariou, A, Geri, G, Bonnetain, F, Marijon, E, Empana, J, Mirouse, A, Resche Rigon, M, Mayaux, J, Rabbat, A, Meert, A, Benoit, D, Bruneel, F, Azoulay, E, Dupuis, C, Schwebel, C, Ruckly, S, Goldgran Toledano, D, Marcotte, G, Lafarge, A, Pichereau, C, Theodose, I, Scotto, M, Kemlin, D, Ghrenassia, E, Schlemmer, B, Vimpere, D, Galicier, L, Contou, D, Guérot, E, Grimaldi, 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P, Boles, J, Herbrecht, J, Kaeuffer, C, Meyer, A, Arfi, K, Lesage, F, Séguret, S, Dupic, L, De Saint Blanquat, L, Baptiste, A, Georges, H, Delannoy, P, Devos, P, Albarracin, D, Ducousso Lacaze, A, Dufour, J, Cabasson, S, Veinstein, A, Chatellier, D, Robert, R, Ha, V, Lau, N, Mimoun, L, Forceville, X, Maamar, A, Chevalier, S, Botoc, V, Rouleau, S, Desachy, A, Calvat, S, Lafon, C, Cracco, C, Temime, J, Molmy, P, Gasan, G, Béranger, A, Chappuy, H, Bertrand, P, Beurton, A, Bodet Contentin, L, Danin, P, Dubois, E, Karaca, Y, Mora, P, Vodovar, D, Desbrosses, Y, Chauchet, A, Daguindau, E, Deconinck, E, Chermak, A, Baron, M, Calvet, L, Sapin, A, Pereira, B, Vettoretti, L, Lacroix, J, Clayton, L, Sabri, E, Bardiaux, L, Tiberghien, P, Hebert, P, Lengliné, E, Socié, G, Borcoman, E, Rusinova, K, Del Galy, A, Mercier, M, Hamel, J, Raveau, T, Moles, M, Clavert, A, Hunault Berger, M, Ifrah, N, Schmidt Tanguy, A, Carreira, S, Lavault, S, Pallanca, O, Morawiec, E, Arnulf, I, D'Humières, T, Carrié, C, Gisbert Mora, C, Bonnardel, E, Biais, M, Hilbert, G, Joannon, T, Marincamp, A, Chiche, J, Ferre, A, Lichtenstein, D, Meziere, G, Gonzalez, C, Hamzaoui, O, Geffriaud, T, Leleu, F, Boissier, F, Cuquemelle, E, Lim, P, Amara, R, Léger, J, Jacob, C, Bouferache, K, Ragot, C, Corradi, L, Maurice, L, Julliand, S, Deho, A, Le Bourgeois, F, Jacquot, A, Valla, F, Letois, F, Salvadori, A, Ottonello, G, Blanot, S, Montmayeur, J, Orliaguet, G, Tarmiz, K, Habas, F, Baleine, J, Lebouhellec, J, Combes, C, Chomton, M, Jouvet, P, Ranchin, B, Macher, M, Gaillot, T, Moine, M, Ageron, F, Jannel, C, Debillon, T, Wroblewski, I, Duprey, M, Jarlier, V, Luyt, C, Longval, T, Schnell, D, Padoin, C, Cohen, Y, Gaies, E, Triki, S, Klouz, A, Moussa, M, Desrumaux, F, May, F, Nguyen, J, Tiercelet, K, Fournier, J, Cherin, M, Kitzis, M, Misset, B, Mathien, C, Poidevin, A, Donatti, L, Mootien, J, Pinto, L, Egard, M, Bodur, G, Barberet, G, Ionescu, C, Ganster, F, Guiot, P, Kuteifan, K, Mpela, A, Chelly, J, Guérin, L, Persichini, R, Hullin, T, Deye, N, Aubertein, P, Paul, M, Bougouin, W, Sandroni, C, Passouant, O, Llitjos, J, Chenevier Gobeaux, C, Batteux, F, Drouet, L, Voicu, S, Henry, P, Dillinger, J, Resiere, D, Dessoy, A, Faivre, V, Damoisel, C, Stiel, L, Galoisy, A, Mauvieux, L, Zobairi, F, Angles Cano, E, Piau, C, Jeannet, R, Feuillard, J, Jolly, L, Boufenzer, A, Carrasco, K, Derive, M, Merdji, H, Belaidouni, N, Toubiana, J, L'Hermitte, Y, Woimant, F, Oppenheim, C, Couvreur, C, Dolveck, F, Devriese, M, Dupeyrat, S, Ray, P, Lefevre, G, Fartoukh, M, Roothaer, N, Carpentier, A, Vaniet, F, Maisonneuve, A, Wiel, E, Canu, S, Hammad, E, Antonini, F, Poirier, M, Vigne, C, Haddam, M, Alingrin, J, Dangers, L, Mangiapan, G, Huet, I, Dhalluin, X, Bautin, N, Quiot, J, De Vecchi, C, Chenivesse, C, Smaoui, M, El Alami, E, Weiss, N, Mochel, F, Galanaud, D, Puybasset, L, Lodey, M, Guiller, E, Vuillaume, C, De Pasquale, F, Demonet, J, Sinnah, F, Dalloz, M, D'Ortho, M, Rouvel Tallec, A, Couret, D, Catan, A, Nativel, B, Planesse, C, Diotel, N, Meilhac, O, Roy Gash, F, Lebard, C, Larbi, A, Gaudin, V, Bonnin, F, Sultan, O, Hoc, C, Mathieu, E, Lapergue, B, Bourdain, F, Caron, M, Parrot, A, Labbe, V, Hafiani, E, Quesnel, C, Genay, S, Décaudin, B, Ethgen, S, Odou, P, Lebuffe, G, Mcquilte, Z, Allaouchiche, B, Verdière, B, Nyunga, M, Banaias, N, Colling, D, Kauv, M, Blondeau, E, Auclin, E, Haw Berlemont, C, Taieb, J, Oudard, S, Morissette, G, Kechaou, W, Litalien, C, Merouani, A, Phan, V, Bouchard, J, Starck, J, Briand, N, Sachs, P, Angoulvant, F, Sommet, J, Holvoet, L, Benkerrou, M, Dreyfus, L, Bordet, F, Touzet, S, Denis, A, Le Coz, J, Chéron, G, Nabbout, R, Patteau, G, Heilbronner, C, Hubert, P, Oualha, M, Crulli, B, Toledano, B, Poirier, N, Vobecky, S, Khouadja, H, Vinet, M, Vinclair, C, Beloncle, F, Radermacher, P, Asfar, P, Coupez, E, Bohé, J, Shinotsuka, C, Caironi, P, Villois, P, Fontana, V, Creteur, J, Pourcine, F, Vong, L, Weyer, C, Akando, B, Abdallah, R, Wetzstein, M, Antier, N, Serroukh, Y, Boudjeltia, K, Joosten, A, Rousseau, A, Delabranche, X, Grunebaum, L, Mootien, Y, Gaci, R, Garric, J, Delbove, A, Darreau, C, Dargent, A, Soudry Faure, A, De Chambrun, M, Demondion, P, Blanchard, J, Chocron, S, Meneveau, N, Corsi, F, Meynieu, P, Repusseau, B, Germain, A, Baudry, G, Hierle, L, Besch, G, Thomas, G, Cassir, N, Dizier, S, Roch, A, Trebbia, G, Govindaradjou, K, Devaquet, J, Picard, C, Parquin, F, Leguen, M, Felten, M, Sage, E, Chapelier, A, Duruisseaux, M, Fleury, J, Antoine, M, Carette, M, Wislez, M, Givel, C, De Margerie Mellon, C, De Kerviler, E, Tandjaoui Lambiotte, Y, Freynet, O, Baux, E, Das, V, Talec, P, Anguel, N, Louis, G, Girerd, N, Tallon, P, Hadchouel Duvergé, A, Salvi, N, Cairet, P, Delacourt, C, Blandine, B, Beraud, L, Lamaziere, A, Lionnet, F, Lehingue, S, D'Journo, X, Jean Marie, F, Thibault, R, Makhlouf, A, Mulliez, A, Dadet, S, Kekstas, G, Preiser, J, Rotovnik, K, Rozalen, I, Kupczyk, K, Krznaric, Z, Cano, N, Pichard, C, Le Roux, B, Jotterand, C, Rooze, S, Moullet, C, Henin, A, Ettori, F, Zemmour, C, Boher, J, Feltry, A, Ben, S, Audibert, J, Conia, A, Gontier, O, Hamrouni, M, Lherm, T, Ouchenir, A, Rétif, J, Proudhom, A, Lagardere, C, Tissot, S, Kalfon, P, Sacre, L, Villa, A, Khadija, A, Garnier, R, Vasset, B, Heinzelman, A, Jouffroy, R, Durand, E, Compagnon, P, Jebri, A, Legout, C, Castot Villepelet, A, Valade, S, Lesieur, O, Delmas, B, Visseaux, B, Cohen, J, Nguyen, L, Morbieu, C, Burdet, C, Lescure, F, Armand Lefevre, L, Yazdanpanah, Y, Houhou Fidouh, N, Cazaux, M, Goff Jérôme, L, Meignin, V, Boutboul, D, Rispail, P, Besnard, N, Ceballos, P, Stoclin, A, Rotolo, F, Wartelle, M, Hicheri, Y, Maillet, S, Chachaty, E, Pignon, J, Bialais, E, Julie, D, Paoloni, L, Wittebolle, X, Hickmann, C, Castanares Zapatero, D, Tordeur, A, Colmant, L, Wittebole, X, Tirone, G, Laterre, P, Ducroux, L, Kemlin, C, Moulton, E, Rosso, C, Le Neindre, A, Mongodi, S, Bouhemad, B, Rodrigues, J, Botteau, C, Waroquier, F, Christiaens, K, Vantrimpont, F, Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE

Abstract

Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study

Published
2016

35. Le xanthoastrocytome pleomorphe anaplasique - A propos d’un cas

Author

Bouaziz, M, Bonamous, K, Laouar, O, and Lankar, A

Abstract

We report a case of anaplastic pleomorphic xanthoastrocytoma occurred in a male of 13 years, who presented a syndrom of intracranial hypertension for a year and a half. CT-scan and MRI revealed a cystic and solid tumor in the left parietal lobe. The surgical resection was total. Histopathological examination demonstrated a pleomorphic xanthoastrocytoma with malignant transformation. Seven months later, the patient has a deterioration of his general condition, the CT revealed a tumor recurrence, which was reoperated. The patient died a few days after surgery. This rare case of anaplastic pleomorphic xanthoastrocytoma is presented, discussed and illustrated in this paper.Nous rapportons un cas de xanthoastrocytome pléomorphe anaplasique chez un garçon de 13 ans. Il présentait un syndrome d’hypertension intracrânienne depuis un an et demi. L’imagerie a visualisé une lésion à double composante kystique et charnue de localisation pariétale gauche. L’exérèse chirurgicale a été totale. L’examen histologique a revélé un xanthoastrocytome pléomorphe anaplasique. Sept mois plus tard, le patient a présenté une altération de l’état général, et le scanner encéphalique a montré une récidive tumorale qui a été réopérée. Le patient est décédé quelques jours après l’intervention.

Published
2013

36. TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: Results from a multicentre EUSTAR study of European caucasian patients

Author

Koumakis, E. Wipff, J. Dieudé, P. Ruiz, B. Bouaziz, M. Revillod, L. Guedj, M. Distler, J.H.W. Matucci-Cerinic, M. Humbert, M. Riemekasten, G. Airo, P. Melchers, I. Hachulla, E. Cusi, D. Wichmann, H.-E. Hunzelmann, N. Tiev, K. Caramaschi, P. Diot, E. Kowal-Bielecka, O. Cuomo, G. Walker, U. Czirják, L. Damjanov, N. Lupoli, S. Conti, C. Müller-Nurasyid, M. Müller-Ladner, U. Riccieri, V. Cracowski, J.-L. Cozzi, F. Bournia, V.K. Vlachoyiannopoulos, P. Chiocchia, G. Boileau, C. Allanore, Y.

Subjects
integumentary system, skin and connective tissue diseases
Abstract

Introduction: Systemic sclerosis (SSc)-related pulmonary arterial hypertension (PAH) has emerged as a major mortality prognostic factor. Mutations of transforming growth factor beta (TGFβ) receptor genes strongly contribute to idiopathic and familial PAH. Objective: To explore the genetic bases of SSc-PAH, we combined direct sequencing and genotyping of candidate genes encoding TGFβ receptor family members. Materials and methods: TGFβ receptor genes, BMPR2, ALK1, TGFR2 and ENG, were sequenced in 10 SSc-PAH patients, nine SSc and seven controls. In addition, 22 single-nucleotide polymorphisms (SNP) of these four candidate genes were tested for association in a fi rst set of 824 French Caucasian SSc patients (including 54 SSc-PAH) and 939 controls. The replication set consisted of 1516 European SSc (including 219 SSc-PAH) and 3129 controls from the European League Against Rheumatism Scleroderma Trials and Research group network. Results: No mutation was identified by direct sequencing. However, two repertoried SNP, ENG rs35400405 and ALK1 rs2277382, were found in SSc-PAH patients only. The genotyping of 22 SNP including the latter showed that only rs2277382 was associated with SSc-PAH (p=0.0066, OR 2.13, 95% CI 1.24 to 3.65). Nevertheless, this was not replicated with the following result in combined analysis: p=0.123, OR 0.79, 95% CI 0.59 to 1.07. Conclusions: This study demonstrates the lack of association between these TGFβ receptor gene polymorphisms and SSc-PAH using both sequencing and genotyping methods.

Published
2012

37. TGFbeta receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patients

Author

Koumakis, E, Wipff, J, Dieudè, P, Ruiz, B, Bouaziz, M, Revillod, L, Guedj, M, Distler, J, Matucci Cerinic, M, Humbert, M, Riemekasten, G, Airò, P, Melchers, I, Hachulla, E, Cusi, D, Wichmann, H, Hunzelmann, N, Tiev, K, Caramaschi, Paola, Diot, E, Kowal Bielecka, O, Cuomo, G, Walker, U, Czirjak, L, Damjanov, N, Lupoli, S, Conti, C, Muller Nurasyid, M, Muller Ladner, U, Riccieri, V, Cracowski, Jl, Cozzi, F, Bournia, V, Vlachoyiannopouls, P, Chiocchia, G, Boileau, C, and Allanore, Y.

Subjects
GENETICS, SYSTEMIC SCLEROSIS, PULMONARY ARTERIAL HYPERTENSION
Published
2012

40. Techno-economic and environmental analysis of an integrated solar vacuum membrane distillation system for the treatment of reverse osmosis desalination brine.

Author

Triki, Z., Bouaziz, M. N., and Boumaza, M.

Subjects
SALINE water conversion, REVERSE osmosis, MEMBRANE distillation, SALT, SOLAR collectors, OSMOTIC pressure
Abstract

Reverse osmosis (RO) desalination is widely used for drinking water production, because of its relatively low energy consumption. However, RO is limited in recovery ratio due to the osmotic pressure which increases with salinity. It results with high rejected brine volume inducing negative environmental impact. The aim of this work is to investigate the possibility of using solar vacuum membrane distillation (VMD) in an integrated RO desalination process in order to reduce brine discharge volume and increase RO global recovery ratio. A small RO desalination unit operated by solar energy in a real site in the Algerian desert is considered for the feasibility study. The obtained results proved that important permeate fluxes can be reached with RO coupled with VMD as the water recovery increased from 37% to nearly 87.5%. Brine volume can so be reduced by a factor of 5 and the global water production is more than doubled. A sensitivity analysis was also carried out to study the effects of operating conditions on the desalination system performance in terms of feed water temperature, vacuum pressure and solar collector efficiency. Finally, an economic study was performed to estimate the cost of water produced from the three possible configurations: the RO alone, the VMD alone and the RO-VMD combined system. [ABSTRACT FROM AUTHOR]

Published
2017
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41. Computation of convective heat transfer coefficient for finite inclined and isothermal plate.

Author

Bouksani, M. and Bouaziz, M. N.

Subjects
*HEAT transfer, *ISOTHERMAL flows, *FINITE element method, *DIFFERENTIAL equations, *BOUNDARY layer equations
Abstract

In order to compute the convective heat transfer coefficient, the present study develops a new technical approach of the constitutive equations of the fluid, based on a realistic physical model of heat transfer for an inclined and an isothermal plate with finite dimensions. Two separate regions with different fluid motions are distinguished. Using suitable transformations of differential equations, the similarity ordinary differential equations were obtained and then solved by an appropriate and simple finite difference method. The analysis of numerical results for some special cases of inclination with visualization photographs is found to be in very good agreement. Numerical results for the dimensionless velocity and temperature profiles are obtained and reported graphically for various values of the parameters entering into the problem. It has observed that Lorenz forces are suitable to control the velocity. Discrepancy between the quasi-analytical formula and the present numerical results are recorded for the Nusselt number and for both the two regions. [ABSTRACT FROM AUTHOR]

Published
2017
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42. Influence of thermophoresis on MHD micropolar fluid over a moved permeable plate.

Author

Alouaoui, R. and Bouaziz, M. N.

Subjects
*THERMOPHORESIS, *TEMPERATURE effect, *HEAT transfer, *MASS transfer, *MAGNETIC fields
Abstract

This work investigates mainly the magnetic field and the thermophoresis effects on the heat and mass transfer in steady laminar boundary layer flow of an incompressible viscous micropolar fluid over a moving vertical and permeable plate subjected to a magnetic field without neglecting the resulting dissipation. The governing differential equations are transformed into the ordinary differential equations which are solved numerically. Results are displayed graphically to illustrate the influence of Magnetic parameter, Thermophoretic parameter, and suction/injection parameter on velocity, microrotation, temperature and species concentration profiles. The rate of mass transfer is affected strongly by Thermophoretic parameter while the local skin-friction coefficient and the local wall couple stress are sensitive to the variations of the magnetic field and to the suction case. The micropolarity controls the shear stress but plays a limited role for the others quantities. Heat and mass transfer rate can be regulated principally by the use of a permeable plate with suction. [ABSTRACT FROM AUTHOR]

Published
2017
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43. Performance and cost evaluation of an autonomous solar vacuum membrane distillation desalination plant.

Author

Trikia, Z., Bouaziz, M. N., and Boumaza, M.

Subjects
MEMBRANE distillation, SALINE water conversion, SOLAR power plants, SOLAR collectors, LATENT heat, ENERGY consumption, DISTILLED water
Abstract

The aim of this work is to investigate the overall performance of an autonomous solar vacuum membrane distillation (VMD) plant for seawater desalination. The system performance was evaluated in terms of several indicators, such as membrane flux rate (MFR), gained output ratio (GOR), performance ratio (PR), recovery ratio (RR) and specific thermal energy consumption (STEC). The obtained results were compared with the reported values from published operational parameters of various solar-powered membrane distillation systems previously tested in literature. The maximum values of MFR, GOR, PR and RR were found to be 14 L/h·m², 3.3, 0.95 kg/MJ and 4.66%, respectively. In addition, the minimum value achieved for STEC was 290 kWh/m³ by a recovery of the latent heat of condensation. Besides, a sensitivity analysis was carried out to study the effect of some operating parameters on GOR performance. The results showed that the GOR can be maximized at low feed flow rate and high feed temperature. A higher GOR value can also be attained with an increase in vacuum level and solar collector area. Finally, an economic study was performed to estimate the expected cost of distilled water produced by the solar VMD plant. [ABSTRACT FROM AUTHOR]

Published
2017
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44. Clinical manifestations of systemic paraphenylene diamine intoxication

Author

Kallel H, Chelly H, Dammak H, Mabrouk Bahloul, Ksibi H, Cb, Hamida, Chaari A, Rekik N, Me, Broe, and Bouaziz M

Subjects
Human medicine
Abstract

Background: To report clinical symptoms and outcome of systemic paraphenylene diamine (PPD) intoxication. Methods: Our study was retrospective. It was conducted over 6 yrs (1994-2000) in die medical intensive care unit (ICU) of a university hospital and it concerned 19 patients hospitalized for systemic PPD intoxication. Results: The mean age (+/- SD) was 27.9 +/- 16.8 yrs, the sex ratio was about 0.58 and the Simplified Acute Physiology Score (SAPS II) was 30 +/- 27. At admission, clinical symptoms were dominated by cervicofacial edema (79%), chocolate brown colored urine (74%), upper airway tract edema (68.4%), oliguria (36.8%), muscular edema (26.3%) and shock (26.3%). The biological results were dominated by rhabdomyolysis (100%), metabolic acidosis (100%), acute renal failure (ARF) (47.4%) and hyperkalemia (26.3%) (biological disturbances were more pronounced in patients with ARF). The therapies used were gastric lavage (100%), fluid infusion (100%), mechanical ventilation (84.2%), alcalinization (80%), corticosteroids (84.2%), vasopressors (26.3%) and renal replacement therapy (26.3%). The intoxication evolution was marked by the death of six patients (31.6%); five of them had developed ARE The mechanical ventilation duration and the ICU stay were both more prolonged in patients who developed ARE Conclusions: Clinical manifestations of systemic PPD intoxication were associated with respiratory, muscular, renal and hemodynamic syndromes. ARF occurrence testifies to the severity of the intoxication.

Published
2005

46. This title is unavailable for guests, please login to see more information.

Author

Koumakis, E. Wipff, J. Dieudé, P. Ruiz, B. Bouaziz, M. Revillod, L. Guedj, M. Distler, J.H.W. Matucci-Cerinic, M. Humbert, M. Riemekasten, G. Airo, P. Melchers, I. Hachulla, E. Cusi, D. Wichmann, H.-E. Hunzelmann, N. Tiev, K. Caramaschi, P. Diot, E. Kowal-Bielecka, O. Cuomo, G. Walker, U. Czirják, L. Damjanov, N. Lupoli, S. Conti, C. Müller-Nurasyid, M. Müller-Ladner, U. Riccieri, V. Cracowski, J.-L. Cozzi, F. Bournia, V.K. Vlachoyiannopoulos, P. Chiocchia, G. Boileau, C. Allanore, Y. and Koumakis, E. Wipff, J. Dieudé, P. Ruiz, B. Bouaziz, M. Revillod, L. Guedj, M. Distler, J.H.W. Matucci-Cerinic, M. Humbert, M. Riemekasten, G. Airo, P. Melchers, I. Hachulla, E. Cusi, D. Wichmann, H.-E. Hunzelmann, N. Tiev, K. Caramaschi, P. Diot, E. Kowal-Bielecka, O. Cuomo, G. Walker, U. Czirják, L. Damjanov, N. Lupoli, S. Conti, C. Müller-Nurasyid, M. Müller-Ladner, U. Riccieri, V. Cracowski, J.-L. Cozzi, F. Bournia, V.K. Vlachoyiannopoulos, P. Chiocchia, G. Boileau, C. Allanore, Y.

Published
2012

47. Independent replication and metaanalysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis

Author

Coustet, B., Bouaziz, M., Dieude, P., Guedj, M., Bossini-Castillo, L., Agarwal, S., Radstake, T.R., Martin, J., Gourh, P., Elhai, M., Koumakis, E., Avouac, J., Ruiz, B., Mayes, M., Arnett, F., Hachulla, E., Diot, E., Cracowski, J.L., Tiev, K., Sibilia, J., Mouthon, L., Frances, C., Amoura, Z., Carpentier, P.H., Cosnes, A., Meyer, O., Kahan, A., Boileau, C., Chiocchia, G., Allanore, Y., Coustet, B., Bouaziz, M., Dieude, P., Guedj, M., Bossini-Castillo, L., Agarwal, S., Radstake, T.R., Martin, J., Gourh, P., Elhai, M., Koumakis, E., Avouac, J., Ruiz, B., Mayes, M., Arnett, F., Hachulla, E., Diot, E., Cracowski, J.L., Tiev, K., Sibilia, J., Mouthon, L., Frances, C., Amoura, Z., Carpentier, P.H., Cosnes, A., Meyer, O., Kahan, A., Boileau, C., Chiocchia, G., and Allanore, Y.

Abstract

Item does not contain fulltext, OBJECTIVE: Independent replication with large cohorts and metaanalysis of genetic associations are necessary to validate genetic susceptibility factors. The known tumor necrosis factor (ligand) superfamily, member 4 gene (TNFSF4) systemic lupus erythematosus (SLE) risk locus has been found to be associated with systemic sclerosis (SSc) in 2 studies, but with discrepancies between them for genotype-phenotype correlation. Our objective was to validate TNFSF4 association with SSc and determine the subset with the higher risk. METHODS: Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry. Genotype-phenotype association analysis and metaanalysis of available data were performed, providing a population study of 4989 patients with SSc and 4661 controls, all of European white ancestry. RESULTS: Allelic and genotypic associations were observed for the 5 single-nucleotide polymorphisms (SNP) with the subset of patients with SSc who are positive for anticentromere antibodies (ACA) and only a trend for association with SSc and limited cutaneous SSc. Rs2205960 exhibited the strongest allelic association in ACA+ patients with SSc [p = 0.0015; OR 1.37 (1.12-1.66)], with significant intra-cohort association when compared to patients with SSc positive for ACA. Metaanalysis confirmed overall association with SSc but also raised preferential association with the ACA+ subset and strongest effect with rs2205960 [T allele p = 0.00013; OR 1.33 (1.15-1.54) and TT genotype p = 0.00046; OR 2.02 (1.36-2.98)]. CONCLUSION: We confirm TNFSF4 as an SSc susceptibility gene and rs2205960 as a putative causal variant with preferential association in the ACA+ SSc subphenotype.

Published
2012

49. Résultats à 1 an de l’oxygénothérapie hyperbare pour lésions de cystite radique

Author

Bouaziz, M., primary, Genestal, M., additional, Bachaud, J., additional, Beauval, J., additional, Rollin, G., additional, Rouvellat, P., additional, Delaunay, B., additional, Sallusto, F., additional, Bellec, L., additional, Doumerc, N., additional, Thoulouzan, M., additional, Gamé, X., additional, Malavaud, B., additional, Soulié, M., additional, Rischmann, P., additional, and Huyghe, E., additional

Published
2013
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