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1. Adeno-associated virus 2 infection in children with non-A–E hepatitis

Author

Ho, Antonia, Orton, Richard, Tayler, Rachel, Asamaphan, Patawee, Herder, Vanessa, Davis, Chris, Tong, Lily, Smollett, Katherine, Manali, Maria, Allan, Jay, Rawlik, Konrad, McDonald, Sarah E., Vink, Elen, Pollock, Louisa, Gannon, Louise, Evans, Clair, McMenamin, Jim, Roy, Kirsty, Marsh, Kimberly, Divala, Titus, Holden, Matthew T. G., Lockhart, Michael, Yirrell, David, Currie, Sandra, O’Leary, Maureen, Henderson, David, Shepherd, Samantha J., Jackson, Celia, Gunson, Rory, MacLean, Alasdair, McInnes, Neil, Bradley-Stewart, Amanda, Battle, Richard, Hollenbach, Jill A., Henderson, Paul, Odam, Miranda, Chikowore, Primrose, Oosthuyzen, Wilna, Chand, Meera, Hamilton, Melissa Shea, Estrada-Rivadeneyra, Diego, Levin, Michael, Avramidis, Nikos, Pairo-Castineira, Erola, Vitart, Veronique, Wilkie, Craig, Palmarini, Massimo, Ray, Surajit, Robertson, David L., da Silva Filipe, Ana, Willett, Brian J., Breuer, Judith, Semple, Malcolm G., Turner, David, Baillie, J. Kenneth, and Thomson, Emma C.

Published
2023
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3. Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIV

Author

Stirrup, Oliver T., Sabin, Caroline A., Phillips, Andrew N., Williams, Ian, Churchill, Duncan, Tostevin, Anna, Hill, Teresa, Dunn, David T., Asboe, David, Pozniak, Anton, Cane, Patricia, Chadwick, David, Clark, Duncan, Collins, Simon, Delpech, Valerie, Douthwaite, Samuel, Dunn, David, Fearnhill, Esther, Porter, Kholoud, Stirrup, Oliver, Fraser, Christophe, Geretti, Anna Maria, Gunson, Rory, Hale, Antony, Hué, Stéphane, Lazarus, Linda, Leigh-Brown, Andrew, Mbisa, Tamyo, Mackie, Nicola, Orkin, Chloe, Nastouli, Eleni, Pillay, Deenan, Phillips, Andrew, Sabin, Caroline, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Volz, Erik, Zhang, Hongyi, Fairbrother, Keith, Dawkins, Justine, O’Shea, Siobhan, Mullen, Jane, Cox, Alison, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Booth, Clare, Renwick, Lynne, Schmid, Matthias L., Payne, Brendan, Hubb, Jonathan, Dustan, Simon, Kirk, Stuart, Bradley-Stewart, Amanda, Jose, Sophie, Thornton, Alicia, Huntington, Susie, Glabay, Adam, Shidfar, Shaadi, Lynch, Janet, Hand, James, de Souza, Carl, Perry, Nicky, Tilbury, Stuart, Youssef, Elaney, Gazzard, Brian, Nelson, Mark, Mabika, Tracey, Mandalia, Sundhiya, Anderson, Jane, Munshi, Sajid, Post, Frank, Adefisan, Ade, Taylor, Chris, Gleisner, Zachary, Ibrahim, Fowzia, Campbell, Lucy, Baillie, Kirsty, Gilson, Richard, Brima, Nataliya, Ainsworth, Jonathan, Schwenk, Achim, Miller, Sheila, Wood, Chris, Johnson, Margaret, Youle, Mike, Lampe, Fiona, Smith, Colette, Tsintas, Rob, Chaloner, Clinton, Hutchinson, Samantha, Walsh, John, Mackie, Nicky, Winston, Alan, Weber, Jonathan, Ramzan, Farhan, Carder, Mark, Leen, Clifford, Wilson, Alan, Morris, Sheila, Gompels, Mark, Allan, Sue, Palfreeman, Adrian, Lewszuk, Adam, Kegg, Stephen, Faleye, Akin, Ogunbiyi, Victoria, Mitchell, Sue, Hay, Phillip, Kemble, Christian, Martin, Fabiola, Russell-Sharpe, Sarah, Gravely, Janet, Allan, Sris, Harte, Andrew, Tariq, Anjum, Spencer, Hazel, Jones, Ron, Pritchard, Jillian, Cumming, Shirley, Atkinson, Claire, Mital, Dushyant, Edgell, Veronica, Allen, Juli, Ustianowski, Andy, Murphy, Cynthia, Gunder, Ilise, Trevelion, Roy, and Babiker, Abdel

Published
2019
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4. Characterisation of a Hepatitis C Virus Subtype 2a Cluster in Scottish PWID with a Suboptimal Response to Glecaprevir/Pibrentasvir Treatment

Author

Shah, Rajiv, primary, Barclay, Stephen T., additional, Peters, Erica S., additional, Fox, Ray, additional, Gunson, Rory, additional, Bradley-Stewart, Amanda, additional, Shepherd, Samantha J., additional, MacLean, Alasdair, additional, Tong, Lily, additional, van Vliet, Vera Jannie Elisabeth, additional, Ngan Chiu Bong, Michael, additional, Filipe, Ana, additional, Thomson, Emma C., additional, and Davis, Chris, additional

Published
2022
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5. Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

Author

Jose, S., Quinn, K., Dunn, D., Cox, A., Sabin, C., Fidler, S., Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Johnson, Margaret, Kegg, Stephen, Leen, C., Martin, Fabiola, Nelson, Mark, Palfreeman, Adrian, Post, F., Pritchard, Jillian, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Walsh, John, Hill, Teresa, Jose, Sophie, Phillips, Andrew, Sabin, Caroline, Thornton, Alicia, Dunn, David, Glabay, Adam, Fisher, M., Perry, N., Tilbury, S., Youssef, E., Churchill, D., Gazzard, B., Nelson, M., Everett, R., Asboe, D., Mandalia, S., Korat, H., Taylor, C., Gleisner, Z., Ibrahim, F., Campbell, L., Gilson, R., Brima, N., Williams, I., Johnson, M., Youle, M., Lampe, F., Smith, C., Tsintas, R., Chaloner, C., Hutchinson, S., Phillips, A., Hill, T., Thornton, A., Huntington, S., Walsh, J., Mackie, N., Winston, A., Weber, J., Ramzan, F., Carder, M., Orkin, C., Lynch, J., Hand, J., de Souza, C., Anderson, J., Munshi, S., Ainsworth, J., Schwenk, A., Miller, S., Wood, C., Wilson, A., Morris, S., Gompels, M., Allan, S., Palfreeman, A., Memon, K., Lewszuk, A., Chadwick, D., Cope, E., Gibson, J., Kegg, S., Main, P., Mitchell, Hunter, Hay, P., Dhillon, M., Martin, F., Russell-Sharpe, S., Harte, A., Clay, S., Tariq, A., Spencer, H., Jones, R., Pritchard, J., Cumming, S., Atkinson, C., Delpech, Valerie, Sachikony, M., Aitken, Celia, Asboe, David, Pozniak, Anton, Cane, Patricia, Chadwick, David, Churchill, Duncan, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, Fearnhill, Esther, Porter, Kholoud, Tostevin, Anna, White, Ellen, Fraser, Christophe, Geretti, Anna Maria, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh-Brown, Andrew, Mbisa, Tamyo, Mackie, Nicola, Moses, Samuel, Orkin, Chloe, Nastouli, Eleni, Pillay, Deenan, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Webster, Daniel, Williams, Ian, Zhang, Hongyi, Greatorex, Jane, O'Shea, Siobhan, Mullen, Jane, Cox, Alison, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia-Diaz, Ana, Shepherd, Jill, Schmid, Matthias L., Payne, Brendan, Pereira, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, Bradley-Stewart, Amanda, and Medical Research Council (MRC)

Subjects
0301 basic medicine, Male, HAART, HIV Infections, Treatment failure, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Antiretroviral Therapy, Highly Active, Pharmacology (medical), 030212 general & internal medicine, Treatment Failure, virological failure, Health Policy, UK CHIC and UK HDRD Steering Committees, Virological failure, 3. Good health, Antiretroviral therapy, Patient benefit, Infectious Diseases, Female, medicine.symptom, Life Sciences & Biomedicine, Viral load, Cart, medicine.medical_specialty, Anti-HIV Agents, Short Communication, antiretroviral therapy, CD4 count, Asymptomatic, 03 medical and health sciences, HIV-INFECTION, Virology, Internal medicine, Drug Resistance, Viral, medicine, Humans, Science & Technology, business.industry, HIV resistance, 1103 Clinical Sciences, 030112 virology, CD4 Lymphocyte Count, Immunology, Mutation, business
Abstract

Objectives No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer adherence and subsequently higher rates of resistance development. Methods In a large cohort of HIV-positive individuals, we investigated the emergence of new resistance mutations upon virological treatment failure according to the CD4 count at the initiation of cART. Results Of 7918 included individuals, 6514 (82.3%), 996 (12.6%) and 408 (5.2%) started cART with a CD4 count ≤ 350, 351–499 and ≥ 500 cells/μL, respectively. Virological rebound occurred while on cART in 488 (7.5%), 46 (4.6%) and 30 (7.4%) with a baseline CD4 count ≤ 350, 351–499 and ≥ 500 cells/μL, respectively. Only four (13.0%) individuals with a baseline CD4 count > 350 cells/μL in receipt of a resistance test at viral load rebound were found to have developed new resistance mutations. This compared to 107 (41.2%) of those with virological failure who had initiated cART with a CD4 count

Published
2015
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6. European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014

Author

Poelman, Randy, Schuffenecker, Isabelle, Van Leer-Buter, Coretta, Josset, Laurence, Niesters, Hubert G. M., Lina, Bruno, Popow-Kraupp, Theresia, Aberle, Stephan W., Fischer, Thea Kølsen, Midgley, Sofie, Christiansen, Claus Bohn, Waris, Matti, Österback, Riikka, Vuorinen, Tytti, Savolainen-Kopra, Carita, Latronico, Francesca, Blomqvist, Soile, Ikonen, Niina, Lappalainen, Maija, Jääskeläinen, Anne, Smura, Teemu, Pilorge, Léa, Legrand-Quillien, Marie-Christine, Payan, Christopher, Petitjean, Joëlle, Vabret, Astrid, Ribault, Mélanie, Mirand, Audrey, Peigue-Lafeuille, Hélène, Henquell, Cécile, Manoha, Catherine, Bour, Jean-Baptiste, Darniot, Magali, Le Goff, Jérôme, Mercier-Delarue, Séverine, Scieux, Catherine, Pillet, Sylvie, Pozzetto, Bruno, Lepiller, Quentin, Fafi-Kremer, Samira, Stoll-Keller, Françoise, Marque-Juillet, Stéphanie, Coutard, Aymeric, Amara, Marlène, Böttcher, Sindy, Diedrich, Sabine, Eis-Hübinger, Anna Maria, Aldabbagh, Souhaib, Reber, Ulrike, Panning, Marcus, Huzly, Daniela, Bierbaum, Sibylle, Liebert, Uwe G., Maier, Melanie, Carr, Michael J., Tuite, Gráinne, Guerra, Jorge Abboud, O'Gorman, Joanne, De Gascun, Cillian, Baldanti, Fausto, Piralla, Antonio, Esposito, Susanna, Principi, Nicola, Ruggiero, Luca, Opp, Matthias, Donker, Gé, Meijer, Adam, van der Avoort, Harrie, Benschop, Kimberley, de Lange, Marit, Niesters, Hubert, Borger, Renze, Scholvinck, Liesbeth, van der Reijden, Wil, Veenendaal, Dick, Claas, Eric C. J., Vossen, Ann C. T. M., Rahamat-Langendoen, Janette, Melchers, Willem J. G., Koopmans, Marion P. G., van der Eijk, Annemiek A., Pas, Suzan D., Kran, Anne-Marte Bakken, Bragstad, Karoline, Dudman, Susanne Gjeruldsen, Christensen, Andreas, Krokstad, Sidsel, Pancer, Katarzyna, Abramczuk, Edyta, Guiomar, Raquel, Pechirra, Pedro, Cristovão, Paula, Costa, Ines, Tecu, Cristina, Lupulescu, Emilia, Cherciu, Carmen, Goldstein, Emily, Bennett, Susan, Bradley-Stewart, Amanda, Gunson, Rory, Berginc, Natasa, Prosenc, Katarina, Campins, Magda, Gimferrer, Laura, Anton, Andres, López-Labrador, F. Xavier, Pérez, Laura Cano, Puig-Barberá, Joan, Cardona, Concepción Gimeno, Mochón, M Dolores Ocete, Buesa, Javier, Navarro, David, de Lejarazu Leonardo, R. Ortiz, Muñoz, Iván Sanz, Rojo, Silvia, Gozalo-Margüello, Mónica, Balbín, Jesús Agüero, Albert, Jan, Samuelson, Agneta, Östlund, Maria Rotzén, Dyrdak, Robert, Brytting, Mia, Hauzenberger, Elenor, Zakikhany, Katherina, Eriksson, Margareta, Moore, Catherine, Broberg, Eeva, Penttinen, Pasi, Mcculloch, Elaine, Di Lorenzo, Caterina, Wallace, Paul, Van Loon, Anton, Prifert, Christiane, Weißbrich, Benedikt, Adams, Ortwin, Berlin, Labor, Hofmann, Jörg, Schnitzler, Paus, Microbes in Health and Disease (MHD), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Virologie et pathologie humaine (VirPath), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire Microorganismes : Génome et Environnement (LMGE), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Virology, Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Department of Virology, Medicum, and Viral Zoonosis Research Unit

Subjects
Male, Pediatrics, NETHERLANDS, CHILDREN, medicine.disease_cause, Disease Outbreaks, EMERGENCE, Respiratory infection, Epidemiology, Prospective Studies, Child, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, Enterovirus D, Human, 318 Medical biotechnology, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Middle Aged, 3. Good health, Europe, Geography, Infectious Diseases, INFECTIONS, Child, Preschool, Molecular epidemiology, Epidemiological Monitoring, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Enterovirus D68, VP1 sequencing, Adult, medicine.medical_specialty, Adolescent, INHIBITION, Enterovirus D, ta3111, [SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology, RESPIRATORY ILLNESS, Young Adult, SDG 3 - Good Health and Well-being, Virology, Enterovirus Infections, medicine, Humans, Disease burden, Aged, Retrospective Studies, Viral Structural Proteins, PEDIATRIC-PATIENTS, business.industry, Infant, Newborn, ta1182, Infant, Outbreak, Retrospective cohort study, Sequence Analysis, DNA, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Molecular Typing, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], VIRAL 2A PROTEASE, HUMAN RHINOVIRUS, North America, REPLICATION, Enterovirus, business
Abstract

M. Lappalainen, A. Jääskeläinen ja T. Smura ovat työryhmän ESCV-ECDC EV-D68 Study Grp jäseniä. Background: In August and September 2014, unexpected clusters of enterovirus-D68 (EV-D68) infections associated with severe respiratory disease emerged from North-America. In September, the European Centre for Disease Prevention and Control (ECDC) asked European countries to strengthen respiratory sample screening for enterovirus detection and typing in cases with severe respiratory presentations. Objectives: To provide a detailed picture of EV-D68 epidemiology in Europe by conducting a retrospective and prospective laboratory analysis of clinical specimens. Study design: An initiative supported by the European Society for Clinical Virology (ESCV) and ECDC was launched to screen for EV-D68 in respiratory specimens between July 1st and December 1st 2014 in Europe and to sequence the VP1 region of detected viruses for phylogenetic analytic purposes. Results: Forty-two institutes, representing 51 laboratories from 17 European countries, analyzed 17,248 specimens yielding 389 EV-D68 positive samples (2.26%) in 14 countries. The proportion of positive samples ranged between 0 and 25% per country. These infections resulted primarily in mild respiratory disease, mainly detected in young children presenting with wheezing and in immuno-compromised adults. The viruses detected in Europe are genetically very similar to those of the North-American epidemic and the majority (83%) could be assigned to clade B. Except for 3 acute flaccid paralysis (AFP) cases, one death and limited ICU admissions, no severe cases were reported. Conclusions: The European study showed that EV-D68 circulated in Europe during summer and fall of 2014 with a moderate disease burden and different pathogenic profile compared to the North-American epidemic. (C) 2015 The Authors. Published by Elsevier B.V.

Published
2015
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7. Variability and pathogenicity of hepatitis E virus genotype 3 variants

Author

Smith, Donald B., primary, Ijaz, Samreen, additional, Tedder, Richard S., additional, Hogema, Boris, additional, Zaaijer, Hans L., additional, Izopet, Jacques, additional, Bradley-Stewart, Amanda, additional, Gunson, Rory, additional, Harvala, Heli, additional, Kokki, Inka, additional, and Simmonds, Peter, additional

Published
2015
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