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1. Mycobacterial catalase–peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis

Author

Brian M. Greenlee, Edward S. Chen, Richard F. Silver, Frederic B. Askin, David R. Moller, Ying-ying Zhang, Lisa A. Marzilli, Robert J. Cotter, Alvin S. Teirstein, and Zhimin Song

Subjects
Sarcoidosis, medicine.drug_class, Biopsy, T cell, Blotting, Western, Detergents, Immunology, Monoclonal antibody, Immune complex formation, Article, 03 medical and health sciences, 0302 clinical medicine, Immune system, Bacterial Proteins, Antigen, RNA, Ribosomal, 16S, medicine, Humans, Immunology and Allergy, In Situ Hybridization, 030304 developmental biology, Antigens, Bacterial, 0303 health sciences, biology, DNA, Mycobacterium tuberculosis, Catalase, medicine.disease, Acquired immune system, Molecular biology, Recombinant Proteins, 3. Good health, medicine.anatomical_structure, 030228 respiratory system, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, Antibody
Abstract

Sarcoidosis is a disease of unknown etiology characterized by noncaseating epithelioid granulomas, oligoclonal CD4+ T cell infiltrates, and immune complex formation. To identify pathogenic antigens relevant to immune-mediated granulomatous inflammation in sarcoidosis, we used a limited proteomics approach to detect tissue antigens that were poorly soluble in neutral detergent and resistant to protease digestion, consistent with the known biochemical properties of granuloma-inducing sarcoidosis tissue extracts. Tissue antigens with these characteristics were detected with immunoglobulin (Ig)G or F(ab′)2 fragments from the sera of sarcoidosis patients in 9 of 12 (75%) sarcoidosis tissues (150–160, 80, or 60–64 kD) but only 3 of 22 (14%) control tissues (all 62–64 kD; P = 0.0006). Matrix-assisted laser desorption/ionization time of flight mass spectrometry identified Mycobacterium tuberculosis catalase–peroxidase (mKatG) as one of these tissue antigens. Protein immunoblotting using anti-mKatG monoclonal antibodies independently confirmed the presence of mKatG in 5 of 9 (55%) sarcoidosis tissues but in none of 14 control tissues (P = 0.0037). IgG antibodies to recombinant mKatG were detected in the sera of 12 of 25 (48%) sarcoidosis patients compared with 0 of 11 (0%) purified protein derivative (PPD)− (P = 0.0059) and 4 of 10 (40%) PPD+ (P = 0.7233) control subjects, suggesting that remnant mycobacterial catalase–peroxidase is one target of the adaptive immune response driving granulomatous inflammation in sarcoidosis.

Published
2005
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2. Attenuation of Lung Inflammation and Fibrosis in Interferon- γ –Deficient Mice after Intratracheal Bleomycin

Author

Brian M. Greenlee, Edward S. Chen, Marsha Wills-Karp, and David R. Moller

Subjects
Pulmonary and Respiratory Medicine, Pulmonary Fibrosis, Clinical Biochemistry, Enzyme-Linked Immunosorbent Assay, Mice, Inbred Strains, Inflammation, Biology, Bleomycin, Interferon-gamma, Mice, chemistry.chemical_compound, Interferon, Fibrosis, medicine, Animals, RNA, Messenger, Lung, Molecular Biology, Mice, Knockout, medicine.diagnostic_test, Body Weight, Pneumonia, Cell Biology, respiratory system, medicine.disease, Molecular biology, Null allele, Survival Rate, Trachea, Disease Models, Animal, Instillation, Drug, Bronchoalveolar lavage, medicine.anatomical_structure, chemistry, Immunology, Toxicity, Cytokines, Collagen, Interleukin-4, medicine.symptom, Bronchoalveolar Lavage Fluid, medicine.drug
Abstract

Because mouse strains susceptible to bleomycin, such as C57BL/ 6J, tend to produce T helper type 1 (Th1) cytokines in response to immune activation, we hypothesized that the inflammatory response to bleomycin is mediated, in part, by local production of the Th1 cytokine interferon-gamma (IFN-gamma). Consistent with this hypothesis, fibrosis-prone C57BL/6J and A/J mice demonstrated significantly elevated expression of IFN-gamma protein (by enzyme-linked immunosorbent assay) in bronchoalveolar lavage fluid at 24 h, and subsequently increased lung inflammation, weight loss, and mortality 10 d after intratracheal bleomycin administration compared with fibrosis-resistant BALB/c mice or saline control mice. To directly determine a role for IFN-gamma in bleomycin toxicity, we exposed C57BL/6J mice with a homozygous null mutation of the IFN-gamma gene (IFN-gamma[-/-]) and wild-type C57BL/6J mice to intratracheal bleomycin. IFN-gamma(-/-) mice demonstrated significantly lower parenchymal inflammation, weight loss, and mortality 10 d after 5 U/kg intratracheal bleomycin administration compared with control mice. At 3 wk after 1.5 U/kg bleomycin exposure, single lung collagen determined by hydroxyproline assay was significantly lower in IFN-gamma(-/-) mice compared with wild-type C57BL/6J mice. Together, these results suggest that IFN-gamma mediates, in part, bleomycin-induced pulmonary inflammation and fibrosis.

Published
2001
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3. Contents, Vol. 94, 1991

Author

Graham S. LeGros, Hiroshi Yamakawa, K. Takatsu, Ratko Djukanovic, P.G. Holt, J. Bujanowski-Weber, P. Oehme, S. Bianchj, William Roche, I. Knöller, G. Delespesse, Toru Ando, Reinhold Penner, D. Macchia, R. Djukanovic, George W. Ward, Thomas Bieber, T. Furitsu, Makoto Dohi, Susan M. MacDonald, Martin D. Chapman, F. Chavarria, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, John R. Brashler, J. Brom, Pascal Chanez, A. Ciccarelli, T.D. Whalley, M.J. Carmona, E. Saito, Mamoru Ito, H. Behrendt, W. Zachgo, Gabriele Zwadlo-Klarwasser, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, A. de Paulis, G. Schultze-Werninghaus, J.-P. Kinet, B.D. Gomperts, Takeo Juji, Ikuo Akutsu, Richard J. Simpson, S. Wilson, T.H. Lee, Suhad El-Lati, Bernhard Przybilla, J. Oliver, Sesha Reddigari, Monique Vogel, Koki Takahashi, Thomas Iff, L. Mugnai, E. Neher, Nathalie Paul-Eugène, Ph. Lassalle, Takeshi Fukuda, Dean D. Metcalfe, V. Lagente, C.E. O’Neil, Go Matsuzaki, C. McMenamin, Jordan N. Fink, G. Burow, Ch. Lemmermann, Ch. Schweiger, H. Wagner, K. Kurihara, D.R. Springall, Karin Pettenburger, A. Capron, H.Y.A. Lau, R. Wahl, G.J. Gleich, K. Rother, Shigeru Takafuji, W.R. Roche, Kurt Blaser, F. Gambassi, A. Pistelli, M. Bubak, Andrew F. Walls, Jeffrey M. Drazen, S.J. Lane, Johann-Christian Virchow, Akio Mori, J.M. Polak, Dietrich Kraft, Hans L. Spiegelberg, L. Lipponer, Friederike von zur Mühlen, R. zur Strassen, Rihoux Jean-Pierre, Susanne Spitzauer, Werner J. Pichler, Karen Britten, M. Schon-Hegrad, Barbara K. Stout, John Wilson, Hirokazu Okudaira, Otto Scheiner, Mitsuko Kondo, Akira Ishii, Richard Sporik, Daniel Weinreich, M. Keating, W. Dorsch, Manel Jordana, Ch.H. Heusser, Ingrid Enander, Massimo Triggiani, T. Ishizaka, Colin J. Sanderson, Dieter Vieluf, Stephanie A. Shore, J. Anrather, S. Terrados, Claus Bachert, Rosa M. Ten, E.W. Rauterberg, E. Masini, H. Rumpold, Jean Yves Lacoste, T.H.W. Lillie, K. Ohno, Alison M. Campbell, E. Gutierrez, F.L. Pearce, Stephan C. Bischoff, R. Suau, Miguel Blanca, P.H. Howarth, P.K. Jeffery, Robert L. Barker, E. Perez, M. Pfenning, Marshall Plaut, Piotr Kuna, T. Abe, H. Rotermund, Michael A. Lett-Brown, Herbert G. Johnson, Thomas Brunner, C. Ra, U. Ganzer, N. Hyslop, Kazuhiko Akiyoshi, Alain L. de Weck, J. Bews, A. Hartnell, J. Dry, K. Nosbüsch, Rafeul Alam, G. Le Gros, V. Brinkmann, Jacqueline M. Langdon, B. Thomas, P. Heap, Corinne Petit-Frère, A.G. Fernández, Wolfgang Schmutzler, Gianni Marone, Matsunobu Suko, R.W. Gristwood, D. Kraft, G.M. Walsh, A.G. Palma-Carlos, B. Bradley, N.S. Sakaguchi, J.M. Vega, O.-H. Wilhelms, R. Wiewrodt, A. Brini, Stephen R. Durham, M. Lupini, M.A. Reed, Thierry Maisonnet, A. Witzel, Peter J. Barnes, Ch. Brander, Lawrence M. Lichtenstein, A. Koffer, Y. Delneste, Laura Palma-Carlos, Jennifer Cairns, T. Brunnee, Elliott Homer, Diana J. Quint, F. Bettens, Monique Capron, Sohei Makino, Luanda Beck, T. Imai, Takayuki Ohtoshi, A. Akasawa, Lore Koller, Yoji Iikura, Naohiro Watanabe, Ahuva Nissim, J.W. Coleman, A. Ohgimi, D. Befus, J.R. Wilkinson, H. Küster, T. Katsunuma, Ch. Ebner, K.J. Turner, M.P. Piccinni, F. Ledermann, Michael Breitenbach, Bradley J. Undem, A.B. Kay, John E. Salvaggio, Carvalho de Sousa, S.T. Holgate, B. Girn, P. Berga, S. Bent, Gerald J. Gleich, Arnold S. Kirshenbaum, P.B. Boulos, Yoshitaka Ino, M. Breitenbach, R. Rathsack, May Azzawi, Sun Ying, Philippe Godard, J.H. Widdicombe, Rudolf Valenta, Christopher Corrigan, S. Romagnani, D.M. Kemeny, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, John Gordon, C. Brom, F. Leynadier, Gert Kunkel, Gerard Cox, B.F. Weber, D. Diaz-Sanchez, Shinji Motojima, J.W. Wilson, Pieter L.B. Bruijnzeel, P.F. Mannaioni, K. Britten, Allen P. Kaplan, Yutaka Morita, K. Ishida, Erika Jensen-Jarolim, Jack Gauldie, Fiona R. Lake, S. Raspanti, Andrew Grant, R. Fadel, S. Dunnette, Jean Bousquet, Ivan Aebischer, Thomas A.E. Platts-Mills, T. Wyss, Richard D. O’Connor, Larry D. Ward, A.G. Morris, Clemens A. Dahinden, Toshifumi Yuuki, P. Parronchi, Hiroyuki Mochizuki, Gail M. McNutt, D.C. Reason, Martin Krieger, Lawrence E. Gelber, Naoki Inagaki, E. Kilchherr, Elisabeth Boichot, Qiu Gang, F. Gabl, Alec H. Sehon, J.V. Collins, Shiro Kasuya, J. Blomgren, Bernadette Pignol, Motohiro Ebisawa, N. Sakaguchi, Jacalyn H. Pierce, U. Blank, Fu-Tong Liu, Robert A. Seder, R. Hilger, Richard P. Bransford, M. Linssen, Jörg Kleine-Tebbe, P.D. Pare, Kazuhiko Yamamoto, Jean Michel Mencia-Huerta, Michael K. Bach, Pierre Braquet, J. Salvaggio, Reuben J.M. Falkoff, R. Merget, J. Hards, B.J. Holt, D. Strickland, P.E.R. Tatham, A.B. Tonnel, H. Saito, François-B. Michel, K. Akimoto, Jerry Dolovich, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, Tim R. Mosmann, Zelig Eshhar, N. Wallen, Maria Baeza, A.J. Wardlaw, Peter H. Howarth, Robin N. Poston, W. König, R.C. Benyon, M. Lopez, D. Mijic, E. Jarolim, William E. Paul, John P. Caulfield, B. Kunz, Milton A. Martins, Yasushi Okumura, J. Knöller, R. Ciriilo, K. Nieber, Geoffrey A. Stewart, Allen C. Myers, Zami Ben-Sasson, U. Hauser, M. G. Di Bello, Michael Duchêne, C. Baumgarten, C.J. Sanderson, Koji Ito, R. Valenta, M.-H. Jouvin, Menachem Rottem, F. Carswell, A. Miranda, K.R. Tainsh, Kimm J. Hamann, Judah A. Denburg, K. Wagner, Martin K. Church, Qutayba Hamid, O. Mejan, Johannes Ring, J. Fernandez, L. Juhlin, Kiyoshi Takatsu, Martin E. Sanders, Peter W. Heymann, C.E. Reed, P. Wentz-Murtha, Fred D. Finkelman, J. Llupiá, Helmut Rumpold, Stephen T. Holgate, Conceição B. Santos, G.M. Hänsch, W.L. Liu, Christoph Walker, M. Ricci, Ph. Gosset, E. Maggi, J. Wilson, R. Moqbel, and Beda M. Stadler

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1991
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4. Inhibition of human interleukin-12 production by pentoxifylline

Author

Christopher L. Karp, Larry M. Wahl, Maria Wysocka, Brian M. Greenlee, David R. Moller, Giorgio Trinchieri, and Xiaojing Ma

Subjects
Lipopolysaccharide, medicine.medical_treatment, Immunology, Indomethacin, Cell Culture Techniques, Endogeny, Pharmacology, Peripheral blood mononuclear cell, Dexamethasone, Monocytes, Pentoxifylline, chemistry.chemical_compound, Immune system, Transforming Growth Factor beta, medicine, Immunology and Allergy, Humans, RNA, Messenger, Prostaglandin E2, Dose-Response Relationship, Drug, business.industry, Interleukin-12, Interleukin-10, Cytokine, chemistry, Interleukin 12, Leukocytes, Mononuclear, business, medicine.drug, Research Article
Abstract

Pharmacological control of interleukin-12 (IL-12) production may be a key therapeutic strategy for modulating immunological diseases dominated by type-1 cytokine responses. In this study, we investigated the effects of pentoxifylline on the production of IL-12 by human blood mononuclear cells and primary human monocytes stimulated with heat-killed Staphylococcus aureus Cowan strain I (SAC) or lipopolysaccharide (LPS). Pentoxifylline potently suppressed production of IL-12 in a concentration-dependent manner. In these same experiments, tumour necrosis factor-alpha (TNF-alpha) production was inhibited and IL-10 and prostaglandin E2 (PGE2) production was enhanced by treatment with pentoxifylline. Suppression of IL-12 production by pentoxifylline was found to be independent of several known endogenous inhibitors of IL-12, such as IL-10, transforming growth factor-beta (TGF-beta), IL-4 and PGE2. RNase protection assays revealed that pentoxifylline inhibited accumulation of both IL-12 p40 and p35 mRNA, suggesting a predominant mRNA locus for pentoxifylline-induced IL-12 inhibition. Low levels of pentoxifylline added to the suppression of IL-12 production by suboptimal inhibiting doses of dexamethasone, suggesting that this drug combination may have therapeutic utility. These results provide a firm rationale for the use of pentoxifylline in clinical trials of immunological disorders characterized by inappropriate type-1 immune responses.

Published
1997

5. Selective activation and accumulation of oligoclonal V beta-specific T cells in active pulmonary sarcoidosis

Author

Mark C. Liu, David R. Moller, Jeffrey D. Forman, Jonathan T. Klein, Richard F. Silver, and Brian M. Greenlee

Subjects
Interleukin 2, Adult, Male, Receptors, Antigen, T-Cell, alpha-beta, Molecular Sequence Data, Gene Expression, Biology, Lymphocyte Activation, Sarcoidosis, Pulmonary, T-Lymphocyte Subsets, Gene expression, medicine, Humans, Amino Acid Sequence, Peptide sequence, Gene, Lung, Cells, Cultured, Genes, Dominant, medicine.diagnostic_test, Base Sequence, T-cell receptor, General Medicine, Sequence Analysis, DNA, medicine.disease, medicine.anatomical_structure, Bronchoalveolar lavage, Immunology, Interleukin-2, Female, Sarcoidosis, Bronchoalveolar Lavage Fluid, medicine.drug, Research Article
Abstract

Sarcoidosis is a granulomatous disease in which activated T cells, responding to an unidentified stimulus, accumulate at sites of disease such as the lung. To evaluate the hypothesis that active sarcoidosis is characterized by a selective activation and expansion of a limited repertoire of T cell receptor (TCR) specific T cells, we analyzed TCR V beta gene expression in lung and blood T cells of patients with active sarcoidosis and, for comparison, normal individuals using polymerase chain reaction amplification of 20 V beta gene families. Analysis of normal bronchoalveolar lavage T cells revealed TCR V beta distributions similar to that of normal blood, providing evidence for a lack of generalized skewing of the T cell repertoire in the normal, noninfected lung. Compared to normal lung and blood, subgroups of individuals with sarcoidosis demonstrated biased expression of one or more V beta genes in either the lung or blood. Five V beta gene families (V beta 5, V beta 8, V beta 15, V beta 16, and V beta 18) were most frequently utilized in a biased fashion by sarcoid lung or blood T cells. Furthermore, dramatic skewing of the T cell repertoire was apparent when sarcoid lung and blood T cells were expanded by short-term culture with IL-2. Sequence analysis demonstrated a bias in V beta gene expression was usually due to expansion of select V beta-specific clones, some of which contained a similar V(D)J junctional region motif. These observations provide evidence for a selective activation and accumulation of antigen-specific V beta-expressing T cells in sarcoidosis.

Published
1994

6. Correction

Author

Robert J. Cotter, David R. Moller, Frederic B. Askin, Zhimin Song, Lisa A. Marzilli, Alvin S. Teirstein, Edward S. Chen, Ying Zhang, Richard F. Silver, and Brian M. Greenlee

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, Correction, business
Published
2005

7. Biographical Sketch of Dr. Alec H. Sehon

Author

Matsunobu Suko, R.W. Gristwood, A.G. Palma-Carlos, T.H.W. Lillie, K. Ohno, R. Wiewrodt, K. Nosbüsch, Jacqueline M. Langdon, A. Brini, Zelig Eshhar, E. Kilchherr, V. Lagente, C.E. O’Neil, T. Katsunuma, Jean Michel Mencia-Huerta, M. Lopez, Michael K. Bach, D. Mijic, E. Jarolim, F.L. Pearce, E. Perez, Beda M. Stadler, Pierre Braquet, E. Saito, Mamoru Ito, H. Behrendt, N. Wallen, Maria Baeza, A.J. Wardlaw, Ch. Lemmermann, Ch. Schweiger, Bernadette Pignol, A. de Paulis, J. Salvaggio, Reuben J.M. Falkoff, J. Hards, William E. Paul, B.J. Holt, P. Berga, R. Djukanovic, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, Graham S. LeGros, Hiroshi Yamakawa, Yoshitaka Ino, M. Breitenbach, D. Strickland, K. Wagner, Martin K. Church, B. Bradley, Gert Kunkel, Gerard Cox, John P. Caulfield, Milton A. Martins, Yasushi Okumura, Daniel Weinreich, C.E. Reed, M.A. Reed, Thierry Maisonnet, Sesha Reddigari, Monique Vogel, Philippe Godard, J.H. Widdicombe, Robert A. Seder, F. Gabl, Christopher Corrigan, S. Romagnani, J.V. Collins, Jacalyn H. Pierce, O. Mejan, J. Fernandez, Fred D. Finkelman, J. Llupiá, O.-H. Wilhelms, H. Saito, François-B. Michel, A. Witzel, Jean Bousquet, Ivan Aebischer, Lawrence E. Gelber, Naoki Inagaki, Fu-Tong Liu, Thomas A.E. Platts-Mills, T. Wyss, D.M. Kemeny, Elisabeth Boichot, T. Imai, Y. Delneste, Ch. Brander, Stephanie A. Shore, John R. Brashler, Wolfgang Schmutzler, Richard P. Bransford, Fiona R. Lake, Ingrid Enander, W. Zachgo, Gabriele Zwadlo-Klarwasser, S. Terrados, Jennifer Cairns, Rosa M. Ten, R.C. Benyon, J.W. Coleman, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, Shiro Kasuya, Takayuki Ohtoshi, G. Le Gros, D. Diaz-Sanchez, A.B. Tonnel, J. Brom, Pascal Chanez, J. Blomgren, John Gordon, P. Heap, M. Linssen, Jörg Kleine-Tebbe, Manel Jordana, Ch.H. Heusser, K. Akimoto, Jerry Dolovich, T. Ishizaka, Ratko Djukanovic, I. Knöller, Thomas Bieber, Peter H. Howarth, Helmut Rumpold, H. Rumpold, Motohiro Ebisawa, Jean Yves Lacoste, Gianni Marone, P.G. Holt, Pieter L.B. Bruijnzeel, Massimo Triggiani, Karen Britten, D.C. Reason, N. Sakaguchi, N.S. Sakaguchi, Ikuo Akutsu, G. Schultze-Werninghaus, R. Valenta, U. Blank, J.M. Vega, F. Leynadier, C. Ra, Bernhard Przybilla, K. Takatsu, Robin N. Poston, Larry D. Ward, P.K. Jeffery, Stephen R. Durham, J. Bujanowski-Weber, Nathalie Paul-Eugène, J. Dry, E.W. Rauterberg, B. Kunz, Christoph Walker, Richard J. Simpson, S. Wilson, V. Brinkmann, Ph. Lassalle, G. Burow, P.D. Pare, P. Oehme, Rafeul Alam, J. Knöller, R. Ciriilo, Conceição B. Santos, W. König, S. Bianchj, Allen C. Myers, K.R. Tainsh, Thomas Iff, E. Maggi, A. Miranda, T.D. Whalley, William Roche, Kimm J. Hamann, Lawrence M. Lichtenstein, Herbert G. Johnson, Kazuhiko Akiyoshi, Allen P. Kaplan, G. Delespesse, M.J. Carmona, H.Y.A. Lau, Kazuhiko Yamamoto, C. McMenamin, J. Wilson, Peter J. Barnes, Laura Palma-Carlos, A. Akasawa, G.M. Walsh, A. Capron, Toru Ando, W.R. Roche, Qiu Gang, Andrew F. Walls, Monique Capron, Sohei Makino, M. Lupini, Luanda Beck, J. Oliver, C. Baumgarten, L. Mugnai, C.J. Sanderson, Naohiro Watanabe, L. Lipponer, Alec H. Sehon, T. Furitsu, A. Ohgimi, Makoto Dohi, T. Brunnee, Elliott Homer, Diana J. Quint, A. Koffer, Friederike von zur Mühlen, R. Moqbel, Bradley J. Undem, Barbara K. Stout, Arnold S. Kirshenbaum, P.B. Boulos, Judah A. Denburg, M.-H. Jouvin, Werner J. Pichler, Shigeru Takafuji, M. Schon-Hegrad, Michael Breitenbach, G.M. Hänsch, Johannes Ring, J. Anrather, Robert L. Barker, Reinhold Penner, Otto Scheiner, L. Juhlin, Johann-Christian Virchow, Hirokazu Okudaira, E. Masini, S. Dunnette, Gerald J. Gleich, E. Gutierrez, Marshall Plaut, K. Nieber, F. Carswell, Piotr Kuna, R. Hilger, H. Küster, Clemens A. Dahinden, D. Macchia, W.L. Liu, M.P. Piccinni, Colin J. Sanderson, F. Gambassi, Jeffrey M. Drazen, Geoffrey A. Stewart, R. Wahl, G.J. Gleich, R. zur Strassen, R. Merget, M. Ricci, Menachem Rottem, John E. Salvaggio, Qutayba Hamid, Go Matsuzaki, Peter W. Heymann, Martin D. Chapman, P.E.R. Tatham, F. Chavarria, P. Wentz-Murtha, H. Wagner, S.J. Lane, Ph. Gosset, Akio Mori, K. Rother, Dietrich Kraft, Hans L. Spiegelberg, Kurt Blaser, A. Pistelli, Koki Takahashi, Kiyoshi Takatsu, D. Kraft, Martin E. Sanders, R. Suau, Stephen T. Holgate, T. Abe, Thomas Brunner, John Wilson, N. Hyslop, Alain L. de Weck, A. Hartnell, Corinne Petit-Frère, Zami Ben-Sasson, F. Bettens, Lore Koller, Yoji Iikura, U. Hauser, May Azzawi, Yutaka Morita, K. Ishida, M. G. Di Bello, Michael Duchêne, Koji Ito, Martin Krieger, D.R. Springall, Karin Pettenburger, J.M. Polak, Ahuva Nissim, Susanne Spitzauer, D. Befus, J.R. Wilkinson, Ch. Ebner, K.J. Turner, M. Bubak, F. Ledermann, Akira Ishii, Richard Sporik, M. Keating, A.B. Kay, Carvalho de Sousa, S.T. Holgate, B. Girn, S. Bent, Dieter Vieluf, Rihoux Jean-Pierre, W. Dorsch, Mitsuko Kondo, Claus Bachert, T.H. Lee, Suhad El-Lati, George W. Ward, E. Neher, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, M. Pfenning, Dean D. Metcalfe, B.F. Weber, H. Rotermund, Shinji Motojima, J.W. Wilson, Tim R. Mosmann, Michael A. Lett-Brown, K. Kurihara, P.F. Mannaioni, Erika Jensen-Jarolim, Jack Gauldie, S. Raspanti, Andrew Grant, U. Ganzer, R. Fadel, R. Rathsack, Susan M. MacDonald, Toshifumi Yuuki, Sun Ying, B. Thomas, Rudolf Valenta, P. Parronchi, A. Ciccarelli, J.-P. Kinet, B.D. Gomperts, Takeo Juji, C. Brom, Hiroyuki Mochizuki, Gail M. McNutt, Alison M. Campbell, Takeshi Fukuda, K. Britten, Jordan N. Fink, J. Bews, Richard D. O’Connor, Stephan C. Bischoff, Miguel Blanca, P.H. Howarth, A.G. Morris, and A.G. Fernández

Subjects
Gerontology, media_common.quotation_subject, Immunology, Immunology and Allergy, Art history, General Medicine, Art, Biographical sketch, media_common
Published
1991
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