11 results on '"Brightbill, Hans D"'
Search Results
2. TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis
- Author
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Sun, Tianhe, Huang, Zhiyu, Liang, Wei-Ching, Yin, Jianping, Lin, Wei Yu, Wu, Jia, Vernes, Jean-Michel, Lutman, Jeff, Caplazi, Patrick, Jeet, Surinder, Wong, Tiffany, Wong, Manda, DePianto, Daryle J, Morshead, Katrina B, Sun, Kai-Hui, Modrusan, Zora, Vander Heiden, Jason A, Abbas, Alexander R, Zhang, Hua, Xu, Min, N'Diaye, Elsa-Noah, Roose-Girma, Meron, Wolters, Paul J, Yadav, Rajbharan, Sukumaran, Siddharth, Ghilardi, Nico, Corpuz, Racquel, Emson, Claire, Meng, Y Gloria, Ramalingam, Thirumalai R, Lupardus, Patrick, Brightbill, Hans D, Seshasayee, Dhaya, Wu, Yan, and Arron, Joseph R
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Liver Disease ,Digestive Diseases ,Lung ,Aetiology ,2.1 Biological and endogenous factors ,Animals ,Disease Models ,Animal ,Female ,Fibrosis ,Humans ,Mice ,Protein Isoforms ,Transforming Growth Factor beta2 ,Transforming Growth Factor beta3 ,Biological Sciences ,Medical and Health Sciences - Abstract
Transforming growth factor-β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms (TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; however, the postnatal pathological roles and activation mechanisms of TGFβ2 and TGFβ3 have not been well characterized. Here, we show that the latent forms of TGFβ2 and TGFβ3 can be activated by integrin-independent mechanisms and have lower activation thresholds compared to TGFβ1. Unlike TGFB1, TGFB2 and TGFB3 expression is increased in human lung and liver fibrotic tissues compared to healthy control tissues. Thus, TGFβ2 and TGFβ3 may play a pathological role in fibrosis. Inducible conditional knockout mice and anti-TGFβ isoform-selective antibodies demonstrated that TGFβ2 and TGFβ3 are independently involved in mouse fibrosis models in vivo, and selective TGFβ2 and TGFβ3 inhibition does not lead to the increased inflammation observed with pan-TGFβ isoform inhibition. A cocrystal structure of a TGFβ2-anti-TGFβ2/3 antibody complex reveals an allosteric isoform-selective inhibitory mechanism. Therefore, inhibiting TGFβ2 and/or TGFβ3 while sparing TGFβ1 may alleviate fibrosis without toxicity concerns associated with pan-TGFβ blockade.
- Published
- 2021
3. Targeted alveolar regeneration with Frizzled-specific agonists
- Author
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Nabhan, Ahmad N., Webster, Joshua D., Adams, Jarret J., Blazer, Levi, Everrett, Christine, Eidenschenk, Celine, Arlantico, Alexander, Fleming, Isabel, Brightbill, Hans D., Wolters, Paul J., Modrusan, Zora, Seshagiri, Somasekar, Angers, Stephane, Sidhu, Sachdev S., Newton, Kim, Arron, Joseph R., and Dixit, Vishva M.
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- 2023
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4. BMP1 is not required for lung fibrosis in mice
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Ma, Hsiao-Yen, N’Diaye, Elsa-Noah, Caplazi, Patrick, Huang, Zhiyu, Arlantico, Alexander, Jeet, Surinder, Wong, Aaron, Brightbill, Hans D., Li, Qingling, Wong, Weng Ruth, Sandoval, Wendy, Tam, Lucinda, Newman, Robert, Roose-Girma, Merone, and Ding, Ning
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- 2022
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5. Diffusion tensor MRI is sensitive to fibrotic injury in a mouse model of oxalate-induced chronic kidney disease.
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Virgincar, Rohan S., Wong, Aaron K., Barck, Kai H., Webster, Joshua D., Hung, Jeffrey, Caplazi, Patrick, Choy, Man Kin, Forrest, William F., Bell, Laura C., Crespigny, Alex J. de, Dunlap, Debra, Jones, Charles, Kim, Dong Eun, Weimer, Robby M., Shaw, Andrey S., Brightbill, Hans D., and Xie, Luke
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DIFFUSION magnetic resonance imaging ,CHRONIC kidney failure ,RENAL fibrosis ,DIFFUSION tensor imaging ,LABORATORY mice - Abstract
Chronic kidney disease (CKD) is characterized by inflammation and fibrosis in the kidney. Renal biopsies and estimated glomerular filtration rate (eGFR) remain the standard of care, but these endpoints have limitations in detecting the stage, progression, and spatial distribution of fibrotic pathology in the kidney. MRI diffusion tensor imaging (DTI) has emerged as a promising noninvasive technology to evaluate renal fibrosis in vivo both in clinical and preclinical studies. However, these imaging studies have not systematically identified fibrosis particularly deeper in the kidney where biopsy sampling is limited, or completed an extensive analysis of whole organ histology, blood biomarkers, and gene expression to evaluate the relative strengths and weaknesses of MRI for evaluating renal fibrosis. In this study, we performed DTI in the sodium oxalate mouse model of CKD. The DTI parameters fractional anisotropy, apparent diffusion coefficient, and axial diffusivity were compared between the control and oxalate groups with region of interest (ROI) analysis to determine changes in the cortex and medulla. In addition, voxel-based analysis (VBA) was implemented to systematically identify local regions of injury over the whole kidney. DTI parameters were found to be significantly different in the medulla by both ROI analysis and VBA, which also spatially matched with collagen III immunohistochemistry (IHC). The DTI parameters in this medullary region exhibited moderate to strong correlations with histology, blood biomarkers, hydroxyproline, and gene expression. Our results thus highlight the sensitivity of DTI to the heterogeneity of renal fibrosis and importance of whole kidney noninvasive imaging. NEW & NOTEWORTHY: Chronic kidney disease (CKD) can be characterized by inflammation and fibrosis of the kidney. Although standard of care methods have been limited in scope, safety, and spatial distribution, MRI diffusion tensor imaging (DTI) has emerged as a promising noninvasive technology to evaluate renal fibrosis in vivo. In this study, we performed DTI in an oxalate mouse model of CKD to systematically identify local kidney injury. DTI parameters strongly correlated with histology, blood biomarkers, hydroxyproline, and gene expression. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
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Brightbill, Hans D., Libraty, Daniel H., Krutzik, Stephan R., Yang, Ruey-Bing, Belisle, John T., Bleharski, Joshua R., Maitland, Michael, Norgard, Michael V., Plevy, Scott E., Smale, Stephen T., Brennan, Patrick J., Bloom, Barry R., Godowski, Paul J., and Modlin, Robert L.
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- 1999
7. Host-Tumor Interaction in Ovarian Cancer Spontaneous Release of Tumor Necrosis Factor and Interleukin-1 Inhibitors by Purified Cell Populations from Human Ovarian Carcinoma in Vitro
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Burger, Robert A, Grosen, Elizabeth A, Ioli, Gene R, Van Eden, Marc E, Brightbill, Hans D, Gatanaga, Maki, DiSaia, Philip J, Granger, Gale A, and Gatanaga, Tetsuya
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Rare Diseases ,Cancer ,Ovarian Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Ascitic Fluid ,Carrier Proteins ,Cell Communication ,Cell Count ,Enzyme-Linked Immunosorbent Assay ,Female ,Humans ,Interleukin 1 Receptor Antagonist Protein ,Interleukin-1 ,Lymphocytes ,Macrophages ,Ovarian Neoplasms ,Receptors ,Tumor Necrosis Factor ,Receptors ,Tumor Necrosis Factor ,Type I ,Sialoglycoproteins ,Tumor Cells ,Cultured ,Tumor Necrosis Factor Decoy Receptors ,Tumor Necrosis Factor-alpha ,Paediatrics and Reproductive Medicine ,Oncology & Carcinogenesis ,Clinical sciences ,Oncology and carcinogenesis ,Reproductive medicine - Abstract
The biological activity of tumor necrosis factor (TNF alpha/beta) and interleukin-1 beta (IL-1 beta) can be blocked by soluble, naturally occurring molecules--TNF alpha/beta binding proteins (BP-55 and BP-75), derived from the extracellular portion of the 55- and 75-kDa TNF alpha/beta membrane receptors, and IL-1 receptor antagonist (IL-1ra), respectively. We examined the levels of these cytokines and their inhibitors in cell-free ascites of 18 patients with advanced ovarian carcinoma by ELISA. Levels of both TNF BP and IL-1ra dramatically exceeded those of TNF and IL-1; thus, it is unlikely that these cytokines are active in ascites from patients with this disease. We then elutriated solid tumor samples from three additional patients, yielding pure populations of tumor cells, macrophages, and lymphocytes. Cells were cultured for up to 48 hr and the spontaneous production of TNF, IL-1, and their inhibitors was measured by ELISA. Tumor cells and macrophages both released inhibitors for TNF and IL-1. Tumor cells released IL-1ra and BP-55, while macrophages released IL-1ra and BP-75. Kinetic studies showed that both tumor cells and macrophages produced an initial burst of TNF alpha and IL-1 beta which was overtaken within 48 hr by a sustained production of TNF BP and IL-1ra. Lymphocytes released no TNF alpha or TNF beta, which alone suggests that tumor associated lymphocytes are locally quiescent in vivo. TNF and IL-1 inhibitors originate from tumor cells and tumor associated macrophages and probably block TNF and IL-1 activity locally and regionally in ovarian carcinoma patients. Whether this phenomenon contributes to the pathogenesis of this disease remains to be determined.
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- 1994
8. IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models
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Heredia, Jose E., primary, Sorenson, Clara, additional, Flanagan, Sean, additional, Nunez, Victor, additional, Jones, Charles, additional, Martzall, Angela, additional, Leong, Laurie, additional, Martinez, Andres Paler, additional, Scherl, Alexis, additional, Brightbill, Hans D., additional, Ghilardi, Nico, additional, and Ding, Ning, additional
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- 2022
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9. Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice
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Brightbill, Hans D., Jeet, Surinder, Lin, Zhonghua, Yan, Donghong, Zhou, Meijuan, Tan, Martha, Nguyen, Allen, Yeh, Sherry, Delarosa, Donnie, Leong, Steven R., Wong, Terence, Chen, Yvonne, Ultsch, Mark, Luis, Elizabeth, Ramani, Sree Ranjani, Jackman, Janet, Gonzalez, Lino, Dennis, Mark S., Chuntharapai, Anan, DeForge, Laura, Meng, Y. Gloria, Xu, Min, Eigenbrot, Charles, Lee, Wyne P., Refino, Canio J., Balazs, Mercedesz, and Wu, Lawren C.
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Cell physiology -- Research ,Viral antibodies -- Properties -- Research ,B cells -- Properties -- Research ,Immunoglobulin E -- Properties -- Research ,Antibodies -- Properties -- Research ,Health care industry - Abstract
IgE-mediated hypersensitivity is central to the pathogenesis of asthma and other allergic diseases. Although neutralization of serum IgE with IgE-specific antibodies is in general an efficacious treatment for allergic asthma, one limitation of this approach is its lack of effect on IgE production. Here, we have developed a strategy to disrupt IgE production by generating monoclonal antibodies that target a segment of membrane IgE on human IgE-switched B cells that is not present in serum IgE. This segment is known as the M1' domain, and using genetically modified mice that contain the human M1' domain inserted into the mouse IgE locus, we demonstrated that M1'-specific antibodies reduced serum IgE and IgE-producing plasma cells in vivo, without affecting other immunoglobulin isotypes. M1'-specific antibodies were effective when delivered prophylactically and therapeutically in mouse models of immunization, allergic asthma, and Nippostrongylus brasiliensis infection, likely by inducing apoptosis of IgE-producing B cells. In addition, we generated a humanized M1'-specific antibody that was active on primary human cells in vivo, as determined by its reduction of serum IgE levels and IgE plasma cell numbers in a human PBMC-SCID mouse model. Thus, targeting of human IgE-producing B cells with apopto-sis-inducing M1'-specific antibodies maybe a novel treatment for asthma and allergy., Introduction Elevated serum IgE levels and IgE-mediated hypersensitivity are central to the pathogenesis of atopic diseases such as allergic asthma (1-4). Elevated serum IgE levels cause the upregulation of IgE [...]
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- 2010
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10. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus
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Brightbill, Hans D., primary, Suto, Eric, additional, Blaquiere, Nicole, additional, Ramamoorthi, Nandhini, additional, Sujatha-Bhaskar, Swathi, additional, Gogol, Emily B., additional, Castanedo, Georgette M., additional, Jackson, Benjamin T., additional, Kwon, Youngsu C., additional, Haller, Susan, additional, Lesch, Justin, additional, Bents, Karin, additional, Everett, Christine, additional, Kohli, Pawan Bir, additional, Linge, Sandra, additional, Christian, Laura, additional, Barrett, Kathy, additional, Jaochico, Allan, additional, Berezhkovskiy, Leonid M., additional, Fan, Peter W., additional, Modrusan, Zora, additional, Veliz, Kelli, additional, Townsend, Michael J., additional, DeVoss, Jason, additional, Johnson, Adam R., additional, Godemann, Robert, additional, Lee, Wyne P., additional, Austin, Cary D., additional, McKenzie, Brent S., additional, Hackney, Jason A., additional, Crawford, James J., additional, Staben, Steven T., additional, Alaoui Ismaili, Moulay H., additional, Wu, Lawren C., additional, and Ghilardi, Nico, additional
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- 2018
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11. Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
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Li, Yanchuan, primary, Wang, Hui, additional, Zhou, Xiaofei, additional, Xie, Xiaoping, additional, Chen, Xiang, additional, Jie, Zuliang, additional, Zou, Qiang, additional, Hu, Hongbo, additional, Zhu, Lele, additional, Cheng, Xuhong, additional, Brightbill, Hans D, additional, Wu, Lawren C., additional, Wang, Linfang, additional, and Sun, Shao-Cong, additional
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- 2016
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