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323 results on '"Broekmans, F. J."'

1. Enrichment of cell cycle pathways in progesterone-treated endometrial organoids of infertile women compared to fertile women

Author

MS VPG/Gynaecologie, Metabole ziekten onderzoek 2, Regenerative Medicine and Stem Cells, Metabole ziekten patientenzorg, Child Health, Onderzoek, Infection & Immunity, Bui, B N, Ardisasmita, A I, van de Vliert, F H, Abendroth, M S, van Hoesel, M, Mackens, S, Fuchs, S A, Nieuwenhuis, E E S, Broekmans, F J M, Steba, G S, MS VPG/Gynaecologie, Metabole ziekten onderzoek 2, Regenerative Medicine and Stem Cells, Metabole ziekten patientenzorg, Child Health, Onderzoek, Infection & Immunity, Bui, B N, Ardisasmita, A I, van de Vliert, F H, Abendroth, M S, van Hoesel, M, Mackens, S, Fuchs, S A, Nieuwenhuis, E E S, Broekmans, F J M, and Steba, G S

Published
2024

2. Local production of 17β-oestradiol in the endometrium during the implantation window: a pilot study

Author

Stevens Brentjens, L B P M, primary, Obukhova, D, additional, Delvoux, B, additional, den Hartog, J E, additional, Bui, B N, additional, Mol, F, additional, de Bruin, J P, additional, Besselink, D, additional, Teklenburg, G, additional, Morgan, F, additional, Baker, M, additional, Broekmans, F J M, additional, van Golde, R J T, additional, Zamani Esteki, M, additional, and Romano, A, additional

Published
2023
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3. An integrative analysis of endometrial steroid metabolism and transcriptome in relation to endometrial receptivity in in vitro fertilization patients

Author

MS VPG/Gynaecologie, Fertiliteitartsen, Child Health, Stevens Brentjens, L B P M, Obukhova, D, den Hartog, J E, Delvoux, B, Koskivuori, J, Auriola, S, Häkkinen, M R, Bui, B, van Hoogenhuijze, N E, Mackens, S, Mol, F, de Bruin, J P, Besselink, D, Teklenburg, G, Kukushkina, V, Salumets, A, Broekmans, F J M, van Golde, R J T, Zamani Esteki, M, Romano, A, MS VPG/Gynaecologie, Fertiliteitartsen, Child Health, Stevens Brentjens, L B P M, Obukhova, D, den Hartog, J E, Delvoux, B, Koskivuori, J, Auriola, S, Häkkinen, M R, Bui, B, van Hoogenhuijze, N E, Mackens, S, Mol, F, de Bruin, J P, Besselink, D, Teklenburg, G, Kukushkina, V, Salumets, A, Broekmans, F J M, van Golde, R J T, Zamani Esteki, M, and Romano, A

Published
2023

4. Economic evaluation of endometrial scratching before the second IVF/ICSI treatment: a cost-effectiveness analysis of a randomized controlled trial (SCRaTCH trial)

Author

Hoogenhuijze, N.E. van, Eekelen, R. van, Mol, F., Schipper, I., Groenewoud, E.R., Traas, M.A.F., Fleischer, K., Hooff, M.H.A. van, Visser, J., Zanden, M. van der, Wely, M. van, Torrance, H.L., Broekmans, F. J. M., Hoogenhuijze, N.E. van, Eekelen, R. van, Mol, F., Schipper, I., Groenewoud, E.R., Traas, M.A.F., Fleischer, K., Hooff, M.H.A. van, Visser, J., Zanden, M. van der, Wely, M. van, Torrance, H.L., and Broekmans, F. J. M.

Abstract

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Published
2022

5. Economic evaluation of endometrial scratching before the second IVF/ICSI treatment: a cost-effectiveness analysis of a randomized controlled trial (SCRaTCH trial)

Author

van Hoogenhuijze, N E, primary, van Eekelen, R, additional, Mol, F, additional, Schipper, I, additional, Groenewoud, E R, additional, Traas, M A F, additional, Janssen, C A H, additional, Teklenburg, G, additional, de Bruin, J P, additional, van Oppenraaij, R H F, additional, Maas, J W M, additional, Moll, E, additional, Fleischer, K, additional, van Hooff, M H A, additional, de Koning, C H, additional, Cantineau, A E P, additional, Lambalk, C B, additional, Verberg, M, additional, van Heusden, A M, additional, Manger, A P, additional, van Rumste, M M E, additional, van der Voet, L F, additional, Pieterse, Q D, additional, Visser, J, additional, Brinkhuis, E A, additional, den Hartog, J E, additional, Glas, M W, additional, Klijn, N F, additional, van der Zanden, M, additional, Bandell, M L, additional, Boxmeer, J C, additional, van Disseldorp, J, additional, Smeenk, J, additional, van Wely, M, additional, Eijkemans, M J C, additional, Torrance, H L, additional, and Broekmans, F J M, additional

Published
2021
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6. Determinants of successful lifestyle change during a 6-month preconception lifestyle intervention in women with obesity and infertility

Author

Karsten, Matty D. A., van Oers, Anne M., Groen, Henk, Mutsaerts, Meike A. Q., van Poppel, Mireille N. M., Geelen, Anouk, van de Beek, Cornelieke, Painter, Rebecca C., Mol, Ben W. J., Roseboom, Tessa J., Hoek, Annemieke, Burggraaff, J. M., Kuchenbecker, W. K. H., Perquin, D. A. M., Koks, C. A. M., van Golde, R., Kaaijk, E. M., Schierbeek, J. M., Oosterhuis, G. J. E., Broekmans, F. J., Vogel, N. E. A., Lambalk, C. B., van der Veen, F., Klijn, N. F., Mercelina, P. E. A. M., van Kasteren, Y. M., Nap, A. W., Mulder, R. J. A. B., Gondrie, E. T. C. M., de Bruin, J. P., Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, Reproductive Origins of Adult Health and Disease (ROAHD), Value, Affordability and Sustainability (VALUE), Public and occupational health, Pediatric surgery, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), ACS - Atherosclerosis & ischemic syndromes, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Plastic, Reconstructive and Hand Surgery, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, Graduate School, Obstetrics and Gynaecology, and Epidemiology and Data Science

Subjects
Counseling, Male, 0301 basic medicine, Gerontology, Lifestyle intervention, DIABETES PREVENTION PROGRAM, TERM WEIGHT-LOSS, Nutrition and Disease, Psychological intervention, Medicine (miscellaneous), Overweight, 0302 clinical medicine, Weight loss, Voeding en Ziekte, SOCIOECONOMIC-STATUS, PREDICTORS, Determinants, Nutrition and Dietetics, Preconception, Original Contribution, 3. Good health, Weight Reduction Programs, PREGNANCY, Female, medicine.symptom, Adult, Infertility, Adolescent, 030209 endocrinology & metabolism, HEALTH BEHAVIOR, Health Promotion, CLASSIFICATION, Young Adult, 03 medical and health sciences, Intervention (counseling), Weight Loss, CORONARY RISK-FACTORS, medicine, Humans, Obesity, Exercise, Life Style, Socioeconomic status, VLAG, Pregnancy, 030109 nutrition & dietetics, OVERWEIGHT, business.industry, Feeding Behavior, ADULTS, medicine.disease, business, Program Evaluation
Abstract

Purpose To identify demographic, (bio)physical, behavioral, and psychological determinants of successful lifestyle change and program completion by performing a secondary analysis of the intervention arm of a randomized-controlled trial, investigating a preconception lifestyle intervention. Methods The 6-month lifestyle intervention consisted of dietary counseling, physical activity, and behavioral modification, and was aimed at 5–10% weight loss. We operationalized successful lifestyle change as successful weight loss (≥ 5% weight/BMI ≤ 29 kg/m2), weight loss in kilograms, a reduction in energy intake, and an increase in physical activity during the intervention program. We performed logistic and mixed-effect regression analyses to identify baseline factors that were associated with successful change or program completion. Results Women with higher external eating behavior scores had higher odds of successful weight loss (OR 1.10, 95% CI 1.05–1.16). Women with the previous dietetic support lost 0.94 kg less during the intervention period (95% CI 0.01–1.87 kg). Women with higher self-efficacy reduced energy intake more than women with lower self-efficacy (p

Published
2019
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7. Gonadotrophins versus clomiphene citrate with or without IUI in women with normogonadotropic anovulation and clomiphene failure: a cost-effectiveness analysis

Author

Bordewijk, E. M., Weiss, N. S., Nahuis, M. J., Bayram, N., van Hooff, M. H. A., Boks, D. E. S., Perquin, D. A. M., Janssen, C. A. H., van Golde, R. J. T., Lambalk, C. B., Goddijn, M., Hompes, P. G., van der Veen, F., Mol, B. W. J., van Wely, M., Smeenk, J. M. J., Hoek, A., Broekmans, F. J. M., Fleischer, K., de Bruin, J. P., Kaaijk, E. M., Laven, J. S. E., Hendriks, D. J., Gerards, M. H., Bourdrez, P., Gianotten, J., Koks, C., van Hooff, M., Kwee, J., Lambeek, A. F., van Unnik, A. F., Vrouenraets, F. P. J., Cohlen, B. J., van de Laar-van Asseldonk, T. A. M., Nap, A. W., van Rijn-van Weert, J. M., Vollebergh, J. H. A., Klijn, N. F., Rijnsaardt-Lukassen, H. G. M., Sluijmer, A. V., Gastroenterology & Hepatology, Obstetrics & Gynecology, Emergency Medicine, Erasmus School of Economics, Orthopedics and Sports Medicine, Neurology, Erasmus MC other, Obstetrics and gynaecology, APH - Health Behaviors & Chronic Diseases, Amsterdam Reproduction & Development (AR&D), VU University medical center, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Graduate School, APH - Methodology, APH - Personalized Medicine, ARD - Amsterdam Reproduction and Development, Center for Reproductive Medicine, Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), and RS: GROW - R4 - Reproductive and Perinatal Medicine

Subjects
Male, Pregnancy Rate, Cost effectiveness, Cost-Benefit Analysis, medicine.medical_treatment, M-OVIN, law.invention, IUI, Indirect costs, 0302 clinical medicine, Randomized controlled trial, Pregnancy, law, FSH, Treatment Failure, 030212 general & internal medicine, Birth Rate, Insemination, Artificial, CLOMIFENE CITRATE, Netherlands, 030219 obstetrics & reproductive medicine, Obstetrics, Rehabilitation, CYCLES, Obstetrics and Gynecology, Health Care Costs, Cost-effectiveness analysis, POLYCYSTIC-OVARY-SYNDROME, Female, Live birth, Infertility, Female, Live Birth, Anovulation, Adult, medicine.medical_specialty, Clomiphene, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, clomiphene citrate, medicine, Humans, cost-effectiveness, gonadotrophins, business.industry, INFERTILE WOMEN, Fertility Agents, Female, medicine.disease, Pregnancy rate, OVULATION INDUCTION, Reproductive Medicine, polycystic ovary syndrome, SINGLETON, Ovulation induction, business, Gonadotropins
Abstract

STUDY QUESTION: Are six cycles of ovulation induction with gonadotrophins more cost-effective than six cycles of ovulation induction with clomiphene citrate (CC) with or without IUI in normogonadotropic anovulatory women not pregnant after six ovulatory cycles with CC?SUMMARY ANSWER: Both gonadotrophins and IUI are more expensive when compared with CC and intercourse, and gonadotrophins are more effective than CC.WHAT IS KNOWN ALREADY: In women with normogonadotropic anovulation who ovulate but do not conceive after six cycles with CC, medication is usually switched to gonadotrophins, with or without IUI. The cost-effectiveness of these changes in policy is unknown.STUDY DESIGN, SIZE, DURATION: We performed an economic evaluation of ovulation induction with gonadotrophins compared with CC with or without IUI in a two-by-two factorial multicentre randomized controlled trial in normogonadotropic anovulatory women not pregnant after six ovulatory cycles with CC. Between December 2008 and December 2015 women were allocated to six cycles with gonadotrophins plus IUI, six cycles with gonadotrophins plus intercourse, six cycles with CC plus IUI or six cycles with CC plus intercourse. The primary outcome was conception leading to a live birth achieved within 8 months of randomization.PARTICIPANTS/MATERIALS, SETTING, METHODS: We performed a cost-effectiveness analysis on direct medical costs. We calculated the direct medical costs of ovulation induction with gonadotrophins versus CC and of IUI versus intercourse in six subsequent cycles. We included costs of medication, cycle monitoring, interventions, and pregnancy leading to live birth. Resource use was collected from the case report forms and unit costs were derived from various sources. We calculated incremental cost-effectiveness ratios (ICER) for gonadotrophins compared to CC and for IUI compared to intercourse. We used non-parametric bootstrap resampling to investigate the effect of uncertainty in our estimates. The analysis was performed according to the intention-to-treat principle.MAIN RESULTS AND THE ROLE OF CHANCE: We allocated 666 women in total to gonadotrophins and IUI (n = 166), gonadotrophins and intercourse (n = 165), CC and IUI (n = 163), or CC and intercourse (n = 172). Mean direct medical costs per woman receiving gonadotrophins or CC were (sic)4495 versus (sic)3006 (cost difference of (sic)1475 (95% CI: (sic)1457-(sic)1493)). Live birth rates were 52% in women allocated to gonadotrophins and 41% in those allocated to CC (relative risk (RR) 1.24: 95% CI: 1.05-1.46). The ICER was (sic)15 258 (95% CI: (sic)8721 to (sic)63 654) per additional live birth with gonadotrophins. Mean direct medical costs per woman allocated to IUI or intercourse were (sic)4497 versus (sic)3005 (cost difference of (sic)1510 (95% CI: (sic)1492-(sic)1529)). Live birth rates were 49% in women allocated to IUI and 43% in those allocated to intercourse (RR = 1.14: 95% CI: 0.97-1.35). The ICER was (sic)24 361 (95% CI: (sic)-11 290 to (sic)85 172) per additional live birth with IUI.LIMITATIONS, REASONS FOR CAUTION: We allowed participating hospitals to use their local protocols for ovulation induction and IUI, which may have led to variation in costs, but which increases generalizability. Indirect costs generated by transportation or productivity loss were not included. We did not evaluate letrozole, which is potentially more effective than CC.WIDER IMPLICATIONS OF THE FINDINGS: Gonadotrophins are more effective, but more expensive than CC, therefore, the use of gonadotrophins in women with normogonadotropic anovulation who have not conceived after six ovulatory CC cycles depends on society's willingness to pay for an additional child. In view of the uncertainty around the cost-effectiveness estimate of IUI, these data are not sufficient to make recommendations on the use of IUI in these women. In countries where ovulation induction regimens are reimbursed, policy makers and health care professionals may use our results in their guidelines.STUDY FUNDING/COMPETING INTEREST(S): This trial was funded by the Netherlands Organization for Health Research and Development (ZonMw number: 80-82310-97-12067). The Eudract number for this trial is 2008-006171-73. The Sponsor's Protocol Code Number is P08-40. CBLA reports unrestricted grant support from Merck and Ferring. BWM is supported by a NHMRC Practitioner Fellowship (GNT1082548) and reports consultancy for Merck, ObsEva and Guerbet.TRIAL REGISTRATION NUMBER: NTR1449.

Published
2019
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8. P–633 lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity

Author

Wang, Z, primary, Groen, H, additional, Va. Zomeren1, K C, additional, Cantineau, A E P, additional, Va. Oers, A, additional, Va. Montfoort, A P A, additional, Kuchenbecker, W K H, additional, Pelinck, M J, additional, Broekmans, F J, additional, Klijn, N F, additional, Kaaijk, E M, additional, Mol, B W J, additional, Hoek, A, additional, and Echten-Arends, J Va, additional

Published
2021
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9. The efficacy and safety of luteal phase support with progesterone following ovarian stimulation and intrauterine insemination: A systematic review and meta-analysis.

Author

Casarramona, G., Lalmahomed, T., Lemmen, C. H. C., Eijkemans, M. J. C., Broekmans, F. J. M., Cantineau, A. E. P., and Drechsel, K. C. E.

Subjects
INDUCED ovulation, LUTEAL phase, ARTIFICIAL insemination, PROGESTERONE, MULTIPLE pregnancy, FROZEN human embryos
Abstract

The aim of this systematic review and meta-analysis was to update the current evidence for the efficacy and safety of progesterone luteal phase support (LPS) following ovarian stimulation and intrauterine insemination treatment (OS-IUI) for unexplained or mild male infertility. Four additional studies were identified compared to the previous review in 2017. Twelve RCTs (2631 patients, 3262 cycles) met full inclusion criteria. Results from quantitative synthesis suggest that progesterone LPS after OS-IUI leads to higher live birth (RR 1.38, 95%CI [1.09, 1.74]; 7 RCTs, n=1748) and clinical pregnancy rates (RR 1.38, 95% CI [1.21, 1.59]; 11 RCTs, n=2163) than no LPS or placebo. This effect is specifically present in protocols using gonadotropins for OS-IUI (RR 1.41, 95%CI [1.17, 1.71]; 7 RCTs, n=1114), and unclear in protocols involving clomiphene citrate (RR 1.01, 95% CI [0.05, 18.94]; 2 RCTs, n=138). We found no effect of progesterone LPS on multiple pregnancy or miscarriage rates. No correlation between drugdosage or duration of treatment and effect size was seen. Though our results suggest both benefit and safety of progesterone LPS in OS-IUI, evidence is of low to moderate quality and additional well-powered trials are still mandatory to confirm our findings and justify implementation in daily practice. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Reply: Endometrial scratching for embryo implantation failure

Author

MS VPG/Gynaecologie, Biostatistiek Onderzoek, Child Health, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Hoogenhuijze, N E, Eijkemans, M J C, Broekmans, F J M, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Child Health, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Hoogenhuijze, N E, Eijkemans, M J C, and Broekmans, F J M

Published
2021

11. Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with unexplained subfertility: follow-up of two randomized clinical trials

Author

MS VPG/Gynaecologie, Child Health, Wessel, J A, Mol, F, Danhof, N A, Bensdorp, A J, Tjon-Kon Fat, R I, Broekmans, F J M, Hoek, A, Mol, B W J, Mochtar, M H, van Wely, M, INeS and SUPER Study Group, MS VPG/Gynaecologie, Child Health, Wessel, J A, Mol, F, Danhof, N A, Bensdorp, A J, Tjon-Kon Fat, R I, Broekmans, F J M, Hoek, A, Mol, B W J, Mochtar, M H, van Wely, M, and INeS and SUPER Study Group

Published
2021

12. Endometrial scratching in women with one failed IVF/ICSI cycle-outcomes of a randomised controlled trial (SCRaTCH)

Author

MS VPG/Gynaecologie, Infection & Immunity, Biostatistiek Onderzoek, Child Health, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Hoogenhuijze, N E, Mol, F, Laven, J S E, Groenewoud, E R, Traas, M A F, Janssen, C A H, Teklenburg, G, de Bruin, J P, van Oppenraaij, R H F, Maas, J W M, Moll, E, Fleischer, K, van Hooff, M H A, de Koning, C H, Cantineau, A E P, Lambalk, C B, Verberg, M, van Heusden, A M, Manger, A P, van Rumste, M M E, van der Voet, L F, Pieterse, Q D, Visser, J, Brinkhuis, E A, den Hartog, J E, Glas, M W, Klijn, N F, van der Meer, S, Bandell, M L, Boxmeer, J C, van Disseldorp, J, Smeenk, J, van Wely, M, Eijkemans, M J C, Torrance, H L, Broekmans, F J M, MS VPG/Gynaecologie, Infection & Immunity, Biostatistiek Onderzoek, Child Health, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Hoogenhuijze, N E, Mol, F, Laven, J S E, Groenewoud, E R, Traas, M A F, Janssen, C A H, Teklenburg, G, de Bruin, J P, van Oppenraaij, R H F, Maas, J W M, Moll, E, Fleischer, K, van Hooff, M H A, de Koning, C H, Cantineau, A E P, Lambalk, C B, Verberg, M, van Heusden, A M, Manger, A P, van Rumste, M M E, van der Voet, L F, Pieterse, Q D, Visser, J, Brinkhuis, E A, den Hartog, J E, Glas, M W, Klijn, N F, van der Meer, S, Bandell, M L, Boxmeer, J C, van Disseldorp, J, Smeenk, J, van Wely, M, Eijkemans, M J C, Torrance, H L, and Broekmans, F J M

Published
2021

14. Effect of parental and ART treatment characteristics on perinatal outcomes

Author

Pontesilli, M, primary, Hof, M H, additional, Ravelli, A C J, additional, van Altena, A J, additional, Soufan, A T, additional, Mol, B W, additional, Kostelijk, E H, additional, Slappendel, E, additional, Consten, D, additional, Cantineau, A E P, additional, van der Westerlaken, L A J, additional, van Inzen, W, additional, Dumoulin, J C M, additional, Ramos, L, additional, Baart, E B, additional, Broekmans, F J M, additional, Rijnders, P M, additional, Curfs, M H J M, additional, Mastenbroek, S, additional, Repping, S, additional, Roseboom, T J, additional, and Painter, R C, additional

Published
2021
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18. Endometrial scratching in women with one failed IVF/ICSI cycle—outcomes of a randomised controlled trial (SCRaTCH)

Author

van Hoogenhuijze, N E, primary, Mol, F, additional, Laven, J S E, additional, Groenewoud, E R, additional, Traas, M A F, additional, Janssen, C A H, additional, Teklenburg, G, additional, de Bruin, J P, additional, van Oppenraaij, R H F, additional, Maas, J W M, additional, Moll, E, additional, Fleischer, K, additional, van Hooff, M H A, additional, de Koning, C H, additional, Cantineau, A E P, additional, Lambalk, C B, additional, Verberg, M, additional, van Heusden, A M, additional, Manger, A P, additional, van Rumste, M M E, additional, van der Voet, L F, additional, Pieterse, Q D, additional, Visser, J, additional, Brinkhuis, E A, additional, den Hartog, J E, additional, Glas, M W, additional, Klijn, N F, additional, van der Meer, S, additional, Bandell, M L, additional, Boxmeer, J C, additional, van Disseldorp, J, additional, Smeenk, J, additional, van Wely, M, additional, Eijkemans, M J C, additional, Torrance, H L, additional, and Broekmans, F J M, additional

Published
2020
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20. Corrigendum:The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: A prospective study (Human Reproduction (2018) 33 (2002-2009) DOI: 10.1093/humrep/dez065)

Author

Koedooder, R., Singer, M., Schoenmakers, S., Savelkoul, P. H. M., Morré, S. A., de Jonge, J. D., Poort, L., Cuypers, W. J. S. S., Beckers, N. G. M., Broekmans, F. J. M., Cohlen, B. J., den Hartog, J. E., Fleischer, K., Lambalk, C. B., Smeenk, J. M. J. S., Budding, A. E., and Laven, J. S. E.

Abstract

The authors of the above article would like to apologise for errors in Figure 3 of their article. An old version of the figure file image was uploaded by the authors, with sub-sections A, B, C and D rearranged. The correct version of Figure 3 is included overpage. The electronic version of this article has been updated at https://doi.org/10.1093/humrep/dez065. The authors would liketo assure readers that this does not affect any content of the article. (Figure Presented).

Published
2019
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24. Corrigendum. The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study

Author

Koedooder, R, primary, Singer, M, additional, Schoenmakers, S, additional, Savelkoul, P H M, additional, Morré, S A, additional, de Jonge, J D, additional, Poort, L, additional, Cuypers, W J S S, additional, Beckers, N G M, additional, Broekmans, F J M, additional, Cohlen, B J, additional, den Hartog, J E, additional, Fleischer, K, additional, Lambalk, C B, additional, Smeenk, J M J S, additional, Budding, A E, additional, and Laven, J S E, additional

Published
2019
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25. The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study

Author

Koedooder, R, primary, Singer, M, additional, Schoenmakers, S, additional, Savelkoul, P H M, additional, Morré, S A, additional, de Jonge, J D, additional, Poort, L, additional, Cuypers, W J S S, additional, Beckers, N G M, additional, Broekmans, F J M, additional, Cohlen, B J, additional, den Hartog, J E, additional, Fleischer, K, additional, Lambalk, C B, additional, Smeenk, J M J S, additional, Budding, A E, additional, and Laven, J S E, additional

Published
2019
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26. Accurate prediction of the irrelevant remains irrelevant

Author

Child Health, MS VPG/Gynaecologie, Circulatory Health, Torrance, H L, Broekmans, F J M, Mol, B W J, Child Health, MS VPG/Gynaecologie, Circulatory Health, Torrance, H L, Broekmans, F J M, and Mol, B W J

Published
2019

27. Determinants of successful lifestyle change during a 6-month preconception lifestyle intervention in women with obesity and infertility

Author

MS Verloskunde, MS VPG/Gynaecologie, UMC Utrecht, Child Health, Circulatory Health, Karsten, Matty D.A., van Oers, Anne M., Groen, Henk, Mutsaerts, Meike A.Q., van Poppel, Mireille N.M., Geelen, Anouk, van de Beek, Cornelieke, Painter, Rebecca C., Mol, Ben W.J., Roseboom, Tessa J., Hoek, Annemieke, Burggraaff, J. M., Kuchenbecker, W. K.H., Perquin, D. A.M., Koks, C. A.M., van Golde, R., Kaaijk, E. M., Schierbeek, J. M., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, N. E.A., Lambalk, C. B., van der Veen, F., Klijn, N. F., Mercelina, P. E.A.M., van Kasteren, Y. M., Nap, A. W., Mulder, R. J.A.B., Gondrie, E. T.C.M., de Bruin, J. P., the LIFEstyle study group, MS Verloskunde, MS VPG/Gynaecologie, UMC Utrecht, Child Health, Circulatory Health, Karsten, Matty D.A., van Oers, Anne M., Groen, Henk, Mutsaerts, Meike A.Q., van Poppel, Mireille N.M., Geelen, Anouk, van de Beek, Cornelieke, Painter, Rebecca C., Mol, Ben W.J., Roseboom, Tessa J., Hoek, Annemieke, Burggraaff, J. M., Kuchenbecker, W. K.H., Perquin, D. A.M., Koks, C. A.M., van Golde, R., Kaaijk, E. M., Schierbeek, J. M., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, N. E.A., Lambalk, C. B., van der Veen, F., Klijn, N. F., Mercelina, P. E.A.M., van Kasteren, Y. M., Nap, A. W., Mulder, R. J.A.B., Gondrie, E. T.C.M., de Bruin, J. P., and the LIFEstyle study group

Published
2019

28. Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with unexplained subfertility: follow-up of two randomized clinical trials.

Author

Wessel, J A, Mol, F, Danhof, N A, Bensdorp, A J, Fat, R I Tjon-Kon, Broekmans, F J M, Hoek, A, Mol, B W J, Mochtar, M H, Wely, M van, Group, INeS and SUPER Study, Tjon-Kon Fat, R I, van Wely, M, and INeS and SUPER Study Group

Subjects
INFERTILITY treatment, RESEARCH, CLINICAL trials, BIRTH rate, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, INFERTILITY, COMPARATIVE studies, BIRTH weight, FERTILIZATION in vitro, INDUCED ovulation, LONGITUDINAL method
Abstract

Study Question: Does assisted reproduction, such as ovarian stimulation and/or laboratory procedures, have impact on perinatal outcomes of singleton live births compared to natural conception in couples with unexplained subfertility?Summary Answer: Compared to natural conception, singletons born after intrauterine insemination with ovarian stimulation (IUI-OS) had a lower birthweight, while singletons born after IVF had comparable birthweights, in couples with unexplained subfertility.What Is Known Already: Singletons conceived by assisted reproduction have different perinatal outcomes such as low birthweight and a higher risk of premature birth than naturally conceived singletons. This might be due to the assisted reproduction, such as laboratory procedures or the ovarian stimulation, or to an intrinsic factor in couples with subfertility.Study Design, Size, Duration: We performed a prospective cohort study using the follow-up data of two randomized clinical trials performed in couples with unexplained subfertility. We evaluated perinatal outcomes of 472 live birth singletons conceived after assisted reproduction or after natural conception within the time horizon of the studies.Participants/materials, Setting, Methods: To assess the possible impact of ovarian stimulation we compared the singletons conceived after IUI with FSH or clomiphene citrate (CC) and IVF in a modified natural cycle (IVF-MNC) or standard IVF with single embryo transfer (IVF-SET) to naturally conceived singletons in the same cohorts. To further look into the possible effect of the laboratory procedures, we put both IUI and IVF groups together into IUI-OS and IVF and compared both to singletons born after natural conception. We only included singletons conceived after fresh embryo transfers. The main outcome was birthweight presented as absolute weight in grams and gestational age- and gender-adjusted percentiles. We calculated differences in birthweight using regression analyses adjusted for maternal age, BMI, smoking, parity, duration of subfertility and child gender.Main Results and the Role Of Chance: In total, there were 472 live birth singletons. Of the 472 singleton pregnancies, 209 were conceived after IUI-OS (136 with FSH and 73 with CC as ovarian stimulation), 138 after IVF (50 after IVF-MNC and 88 after IVF-SET) and 125 were conceived naturally.Singletons conceived following IUI-FSH and IUI-CC both had lower birthweights compared to naturally conceived singletons (adjusted difference IUI-FSH -156.3 g, 95% CI -287.9 to -24.7; IUI-CC -160.3 g, 95% CI -316.7 to -3.8). When we compared IVF-MNC and IVF-SET to naturally conceived singletons, no significant difference was found (adjusted difference IVF-MNC 75.8 g, 95% CI -102.0 to 253.7; IVF-SET -10.6 g, 95% CI -159.2 to 138.1). The mean birthweight percentile was only significantly lower in the IUI-FSH group (-7.0 percentile, 95% CI -13.9 to -0.2). The IUI-CC and IVF-SET group had a lower mean percentile and the IVF-MNC group a higher mean percentile, but these groups were not significant different compared to the naturally conceived group (IUI-CC -5.1 percentile, 95% CI -13.3 to 3.0; IVF-MNC 4.4 percentile, 95% CI -4.9 to 13.6; IVF-SET -1.3 percentile, 95% CI -9.1 to 6.4).Looking at the laboratory process that took place, singletons conceived following IUI-OS had lower birthweights than naturally conceived singletons (adjusted difference -157.7 g, 95% CI -277.4 to -38.0). The IVF group had comparable birthweights with the naturally conceived group (adjusted difference 20.9 g, 95% CI -110.8 to 152.6). The mean birthweight percentile was significantly lower in the IUI-OS group compared to the natural group (-6.4 percentile, 95% CI -12.6 to -0.1). The IVF group was comparable (0.7 percentile, 95% CI -6.1 to 7.6).Limitations, Reasons For Caution: The results are limited by the number of cases. The data were collected prospectively alongside the randomized controlled trials, but analyzed as treated.Wider Implications Of the Findings: Our data suggest IUI in a stimulated cycle may have a negative impact on the birthweight of the child and possibly on pre-eclampsia. Further research should look into the effect of different methods of ovarian stimulation on placenta pathology and pre-eclampsia in couples with unexplained subfertility using naturally conceived singletons in the unexplained population as a reference.Study Funding/competing Interest(s): Both initial trials were supported by a grant from ZonMW, the Dutch Organization for Health Research and Development (INeS 120620027, SUPER 80-83600-98-10192). The INeS study also had a grant from Zorgverzekeraars Nederland, the Dutch association of healthcare insurers (09-003). B.W.J.M. is supported by an NHMRC investigator Grant (GNT1176437) and reports consultancy for ObsEva, Merck Merck KGaA, Guerbet and iGenomix, outside the submitted work. A.H. reports grants from Ferring Pharmaceutical company (the Netherlands), outside the submitted work. F.J.M.B. receives monetary compensation as a member of the external advisory board for Merck Serono (the Netherlands), Ferring Pharmaceutics BV (the Netherlands) and Gedeon Richter (Belgium), he receives personal fees from educational activities for Ferring BV (the Netherlands) and for advisory and consultancy work for Roche and he receives research support grants from Merck Serono and Ferring Pharmaceutics BV, outside the submitted work. The remaining authors have nothing to disclose.Trial Registration Number: INeS study Trial NL915 (NTR939); SUPER Trial NL3895 (NTR4057). [ABSTRACT FROM AUTHOR]

Published
2021
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29. Cost-effectiveness analysis of lifestyle intervention in obese infertile women

Author

Van Oers, Anne M., Mutsaerts, Meike A Q, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, van Golde, R., Kaaijk, Eugenie M, Schierbeek, Jaap M., Klijn, Nicole F., Van Kasteren, Yvonne M., Land, Jolande A, Mol, B. W J, Hoek, A., Groen, H., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, Niels E A, Lambalk, Cornelis B., Verberg, Marieke F G, Mercelina, Patricia E A M, van der Veen, F, Nap, Annemiek W., Gondrie, Ed T C M, Mulder, Robert J A B, Bruin, Jacob P, Reproductive Origins of Adult Health and Disease (ROAHD), Methods in Medicines evaluation & Outcomes research (M2O), Value, Affordability and Sustainability (VALUE), Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), ACS - Atherosclerosis & ischemic syndromes, Plastic, Reconstructive and Hand Surgery, Afdeling Onderwijs FHML, Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), and RS: GROW - R4 - Reproductive and Perinatal Medicine

Subjects
Male, obesity, Cost effectiveness, Cost-Benefit Analysis, Overweight, Body Mass Index, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Obstetrics and Gynaecology, 030212 general & internal medicine, Birth Rate, Netherlands, Family Characteristics, OUTCOMES, 030219 obstetrics & reproductive medicine, Obstetrics, SUBFERTILE, Rehabilitation, Obstetrics and Gynecology, Cost-effectiveness analysis, scenario analysis, Weight Reduction Programs, PREGNANCY, Female, medicine.symptom, Live birth, infertility, Infertility, Female, Adult, Infertility, medicine.medical_specialty, Patient Dropouts, Reproductive medicine, WEIGHT-LOSS, Fertilization in Vitro, Direct Service Costs, 03 medical and health sciences, DELIVERY, Ovulation Induction, Intervention (counseling), Weight Loss, medicine, Journal Article, Humans, Infant Health, FERTILITY TREATMENT, Healthy Lifestyle, cost-effectiveness, Infertility, Male, COUPLES, Cryopreservation, OVERWEIGHT, business.industry, lifestyle intervention, LIVE BIRTH, Embryo Transfer, medicine.disease, BODY-MASS INDEX, Reproductive Medicine, anovulation, Physical therapy, Lost to Follow-Up, business, Follow-Up Studies
Abstract

STUDY QUESTION What is the cost-effectiveness of lifestyle intervention preceding infertility treatment in obese infertile women? SUMMARY ANSWER Lifestyle intervention preceding infertility treatment as compared to prompt infertility treatment in obese infertile women is not a cost-effective strategy in terms of healthy live birth rate within 24 months after randomization, but is more likely to be cost-effective using a longer follow-up period and live birth rate as endpoint. WHAT IS KNOWN ALREADY In infertile couples, obesity decreases conception chances. We previously showed that lifestyle intervention prior to infertility treatment in obese infertile women did not increase the healthy singleton vaginal live birth rate at term, but increased natural conceptions, especially in anovulatory women. Cost-effectiveness analyses could provide relevant additional information to guide decisions regarding offering a lifestyle intervention to obese infertile women. STUDY DESIGN, SIZE, DURATION The cost-effectiveness of lifestyle intervention preceding infertility treatment compared to prompt infertility treatment was evaluated based on data of a previous RCT, the LIFEstyle study. The primary outcome for effectiveness was the vaginal birth of a healthy singleton at term within 24 months after randomization (the healthy live birth rate). The economic evaluation was performed from a hospital perspective and included direct medical costs of the lifestyle intervention, infertility treatments, medication and pregnancy in the intervention and control group. In addition, we performed exploratory cost-effectiveness analyses of scenarios with additional effectiveness outcomes (overall live birth within 24 months and overall live birth conceived within 24 months) and of subgroups, i.e. of ovulatory and anovulatory women, women

Published
2017
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31. Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault > 30%)? Study protocol of the SCRaTCH-OFO trial: a randomized controlled trial

Author

Bui, B. N., primary, Torrance, H. L., additional, Janssen, C., additional, Cohlen, B., additional, de Bruin, J. P., additional, den Hartog, J. E., additional, van der Linden, P. J. Q., additional, Deurloo, K. L., additional, Maas, J. W. M., additional, van Oppenraaij, R., additional, Cantineau, A., additional, Lambalk, C. B., additional, Visser, H., additional, Brinkhuis, E., additional, van Disseldorp, J., additional, Schoot, B. C., additional, Lardenoije, C., additional, van Wely, M., additional, Eijkemans, M. J. C., additional, and Broekmans, F. J. M., additional

Published
2018
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32. Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault > 30%)? : Study protocol of the SCRaTCH-OFO trial: a randomized controlled trial

Author

Bui, B N, Torrance, H L, Janssen, C, Cohlen, B, de Bruin, J P, den Hartog, J E, van der Linden, P J Q, Deurloo, K L, Maas, J W M, van Oppenraaij, R, Cantineau, A, Lambalk, C B, Visser, H, Brinkhuis, E, van Disseldorp, J, Schoot, B C, Lardenoije, C, van Wely, M, Eijkemans, M J C, Broekmans, F J M, Bui, B N, Torrance, H L, Janssen, C, Cohlen, B, de Bruin, J P, den Hartog, J E, van der Linden, P J Q, Deurloo, K L, Maas, J W M, van Oppenraaij, R, Cantineau, A, Lambalk, C B, Visser, H, Brinkhuis, E, van Disseldorp, J, Schoot, B C, Lardenoije, C, van Wely, M, Eijkemans, M J C, and Broekmans, F J M

Published
2018

33. Follicle stimulating hormone versus clomiphene citrate in intrauterine insemination for unexplained subfertility : a randomized controlled trial

Author

Danhof, N A, van Wely, M, Repping, S, Koks, C, Verhoeve, H R, de Bruin, J P, Verberg, M F G, van Hooff, M H A, Cohlen, B J, van Heteren, C F, Fleischer, K, Gianotten, J, van Disseldorp, J, Visser, J, Broekmans, F J M, Mol, B W J, van der Veen, F, Mochtar, M H, SUPER study group, Danhof, N A, van Wely, M, Repping, S, Koks, C, Verhoeve, H R, de Bruin, J P, Verberg, M F G, van Hooff, M H A, Cohlen, B J, van Heteren, C F, Fleischer, K, Gianotten, J, van Disseldorp, J, Visser, J, Broekmans, F J M, Mol, B W J, van der Veen, F, Mochtar, M H, and SUPER study group

Published
2018

34. Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault > 30%)?: Study protocol of the SCRaTCH-OFO trial: a randomized controlled trial

Author

Fertiliteitartsen, MS VPG/Gynaecologie, Child Health, Regenerative Medicine and Stem Cells, Orthopaedie Opleiding, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectious Diseases, JC onderzoeksprogramma Methodology, Bui, B N, Torrance, H L, Janssen, C, Cohlen, B, de Bruin, J P, den Hartog, J E, van der Linden, P J Q, Deurloo, K L, Maas, J W M, van Oppenraaij, R, Cantineau, A, Lambalk, C B, Visser, H, Brinkhuis, E, van Disseldorp, J, Schoot, B C, Lardenoije, C, van Wely, M, Eijkemans, M J C, Broekmans, F J M, Fertiliteitartsen, MS VPG/Gynaecologie, Child Health, Regenerative Medicine and Stem Cells, Orthopaedie Opleiding, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectious Diseases, JC onderzoeksprogramma Methodology, Bui, B N, Torrance, H L, Janssen, C, Cohlen, B, de Bruin, J P, den Hartog, J E, van der Linden, P J Q, Deurloo, K L, Maas, J W M, van Oppenraaij, R, Cantineau, A, Lambalk, C B, Visser, H, Brinkhuis, E, van Disseldorp, J, Schoot, B C, Lardenoije, C, van Wely, M, Eijkemans, M J C, and Broekmans, F J M

Published
2018

36. Testing for Ovarian Reserve in Assisted Reproduction programs: the current point of view

Author

Broekmans, F. J.

Subjects
ovarian reserve, Original Paper, ovarian ageing, IVF, Assisted reproduction
Abstract

Age related fertility decline varies considerably among women. Therefore, chronological female age, though informative on pregnancy prospects in assisted reproduction, will often not correctly express a woman's reproductive potential. The value of quantitative ovarian reserve tests prior to IVF/ICSI treatment is still subject of debate. From a series of systematic reviews it has become clear that the added value of these tests upon knowing female age has not been clearly established. Still, several tests, like the AFC and AMH are considered adequate in predicting the response to ovarian stimulation. This claim seems to be truer for poor response prediction, compared to hyper response. Prediction of the outcome pregnancy has repeatedly shown to be cumbersome. As management options for predicted poor or hyper responders-- are not fully investigated to date, routine ovarian reserve testing is not to be recommended. A first cycle poor response to adequate stimulation in cases with otherwise no signs of advanced ovarian ageing (based on female-- age and ovarian reserve tests) may offer a tool to identify cases with sufficient prospects for continuation of ART treatment--.

Published
2009

37. Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342)

Author

van Hoogenhuijze, N. E., primary, Torrance, H. L., additional, Mol, F., additional, Laven, J. S. E., additional, Scheenjes, E., additional, Traas, M. A. F., additional, Janssen, C., additional, Cohlen, B., additional, Teklenburg, G., additional, de Bruin, J. P., additional, van Oppenraaij, R., additional, Maas, J. W. M., additional, Moll, E., additional, Fleischer, K., additional, van Hooff, M. H., additional, de Koning, C., additional, Cantineau, A., additional, Lambalk, C. B., additional, Verberg, M., additional, Nijs, M., additional, Manger, A. P., additional, van Rumste, M., additional, van der Voet, L. F., additional, Preys-Bosman, A., additional, Visser, J., additional, Brinkhuis, E., additional, den Hartog, J. E., additional, Sluijmer, A., additional, Jansen, F. W., additional, Hermes, W., additional, Bandell, M. L., additional, Pelinck, M. J., additional, van Disseldorp, J., additional, van Wely, M., additional, Smeenk, J., additional, Pieterse, Q. D., additional, Boxmeer, J.C., additional, Groenewoud, E.R., additional, Eijkemans, M. J. C., additional, Kasius, J. C., additional, and Broekmans, F. J. M., additional

Published
2017
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39. Cost-effectiveness analysis of lifestyle intervention in obese infertile women

Author

MS VPG/Gynaecologie, Circulatory Health, Child Health, Van Oers, Anne M., Mutsaerts, Meike A Q, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, van Golde, R., Kaaijk, Eugenie M, Schierbeek, Jaap M., Klijn, Nicole F., Van Kasteren, Yvonne M., Land, Jolande A, Mol, B. W J, Hoek, A., Groen, H., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, Niels E A, Lambalk, Cornelis B., Verberg, Marieke F G, Mercelina, Patricia E A M, van der Veen, F, Nap, Annemiek W., Gondrie, Ed T C M, Mulder, Robert J A B, Bruin, Jacob P, behalf of the LIFEstyle study group, MS VPG/Gynaecologie, Circulatory Health, Child Health, Van Oers, Anne M., Mutsaerts, Meike A Q, Burggraaff, Jan M., Kuchenbecker, Walter K H, Perquin, Denise A M, Koks, Carolien A M, van Golde, R., Kaaijk, Eugenie M, Schierbeek, Jaap M., Klijn, Nicole F., Van Kasteren, Yvonne M., Land, Jolande A, Mol, B. W J, Hoek, A., Groen, H., Oosterhuis, G. J.E., Broekmans, F. J., Vogel, Niels E A, Lambalk, Cornelis B., Verberg, Marieke F G, Mercelina, Patricia E A M, van der Veen, F, Nap, Annemiek W., Gondrie, Ed T C M, Mulder, Robert J A B, Bruin, Jacob P, and behalf of the LIFEstyle study group

Published
2017

40. Erratum to: Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study

Author

Circulatory Health, MS VPG/Gynaecologie, Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 3, Brain, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Cardiovasculaire Epidemiologie, de Kat, A C, Dam, V, Onland-Moret, N C, Eijkemans, M J C, Broekmans, F J M, van der Schouw, Y T, Circulatory Health, MS VPG/Gynaecologie, Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 3, Brain, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Cardiovasculaire Epidemiologie, de Kat, A C, Dam, V, Onland-Moret, N C, Eijkemans, M J C, Broekmans, F J M, and van der Schouw, Y T

Published
2017

41. Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study

Author

Circulatory Health, MS VPG/Gynaecologie, Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 3, Brain, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Cardiovasculaire Epidemiologie, de Kat, A C, Dam, V, Onland-Moret, N C, Eijkemans, M J C, Broekmans, F J M, van der Schouw, Y T, Circulatory Health, MS VPG/Gynaecologie, Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 3, Brain, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Cardiovasculaire Epidemiologie, de Kat, A C, Dam, V, Onland-Moret, N C, Eijkemans, M J C, Broekmans, F J M, and van der Schouw, Y T

Published
2017

42. BRCA1/2 mutation carriers do not have earlier natural menopause compared to proven non-carriers: report from the Dutch hereditary breast and ovarian cancer study group (HEBON)

Author

van Tilborg, T. C., Broekmans, F. J. M., Schrijver, L. H., Mooij, T. M., Pijpe, A., Oosterwijk, J. C., Verhoef, S., Garcia, E. B. Gomez, van Zelst-Stams, W. A. G., Adank, M. A., van Asperen, C. J., van Doorn, H. C., van Os, T. A. M., Rookus, M. A., Ausems, M. G. E. M., Targeted Gynaecologic Oncology (TARGON), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Published
2014

43. Cost-effectiveness of a structured lifestyle program in overweight and obese subfertile women. Preliminary data from a randomised controlled trial - the LIFEstyle study

Author

van Oers, A. M., Mutsaerts, M. A. Q., Burggraaff, J. M., Kuchenbecker, W. K. H., Perquin, D. A. M., Koks, C. A. M., Van Golde, R., Kaaijk, E. M., Schierbeek, J. M., Oosterhuis, G. J. E., Broekmans, F. J., Land, J. A., Mol, B. W., Hoek, A., Groen, H., Reproductive Origins of Adult Health and Disease (ROAHD), and Methods in Medicines evaluation & Outcomes research (M2O)

Published
2014

44. The effectiveness of a structured lifestyle program in overweight and obese subfertile women. Preliminary data from a randomised controlled trial (LIFEstyle study)

Author

Mutsaerts, M. A. Q., Van Oers, A. M., Groen, H., Burggraaff, J. M., Kuchenbecker, W. K. H., Perquin, D. A. M., Koks, C. A. M., Van Golde, R., Kaaijk, E. M., Schierbeek, J. M., Oosterhuis, G. J. E., Broekmans, F. J., Land, J. A., Mol, B. W., Hoek, A., Methods in Medicines evaluation & Outcomes research (M2O), and Reproductive Origins of Adult Health and Disease (ROAHD)

Published
2014

49. A randomized controlled, non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer

Author

Groenewoud, E. R., Cohlen, B. J., Al-Oraiby, A., Brinkhuis, E. A., Broekmans, F. J M, De Bruin, J. P., Van Den Dool, G., Fleisher, K., Friederich, J., Goddijn, M., Hoek, A., Hoozemans, D. A., Kaaijk, E. M., Koks, C. A M, Laven, J. S E, Van Der Linden, P. J Q, Manger, A. P., Slappendel, E., Spinder, T., Kollen, B. J., Macklon, N. S., Groenewoud, E. R., Cohlen, B. J., Al-Oraiby, A., Brinkhuis, E. A., Broekmans, F. J M, De Bruin, J. P., Van Den Dool, G., Fleisher, K., Friederich, J., Goddijn, M., Hoek, A., Hoozemans, D. A., Kaaijk, E. M., Koks, C. A M, Laven, J. S E, Van Der Linden, P. J Q, Manger, A. P., Slappendel, E., Spinder, T., Kollen, B. J., and Macklon, N. S.

Published
2016

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