Search

Your search keyword '"Burges, D."' showing total 13 results
Start Over Author "Burges, D." Search Limiters Full Text
13 results on '"Burges, D."'

2. Let’s stop dumping cookstoves in local communities. It’s time to get implementation right

Author

Brakema, E.A., Kleij, R.M. van der, Vermond, D., Gemert, F.A. van, Kirenga, B., Chavannes, N.H., An, P.L., Anastasaki, M., Akylbekov, A., Barton, A., Bertsias, A., Binh, P.D.U., J.F.M. van boven, Burges, D., Cartwright, L., Chatzea, V.E., Cragg, L., Dang, T.N., Dautov, I., Emilov, B., Ferarrio, I., Hedrick, B., Hong, L.T.C., Hopkinson, N., Isaeva, E., Jones, R., Jong, C. de, Kampen, S. van, Katagira, W., Kjaergaard, J., Kocks, J., Lan, L.T.T., Linh, T.T.D., Lionis, C., Loan, K.X., Mademilov, M., McEwen, A., Musinguzi, P., Nantanda, R., Ndeezi, G., Papadakis, S., Pinnock, H., Pooler, J., Poot, C.C., Postma, M.J., Poulsen, A., Powell, P., Quynh, N.N., Reventlow, S., Sifaki-Pistolla, D., Singh, S., Sooronbaev, T., Sousa, J.C. de, Stout, J., Ostergaard, M.S., Tabyshova, A., Tsiligianni, I., Tuan, T.D., Tumwine, J., L. van, Vinh, N.N., Walusimbi, S., Warren, L., Williams, S., FRESH AIR Collaborators, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Research Institute for Asthma and COPD (GRIAC), and Microbes in Health and Disease (MHD)

Subjects
Pulmonary and Respiratory Medicine, COUNTRIES, ADOPTION, 010501 environmental sciences, IMPROVED COOKING STOVES, 01 natural sciences, SOLID-FUEL, 03 medical and health sciences, 0302 clinical medicine, Dumping, Medicine, 030212 general & internal medicine, Diffusion (business), 0105 earth and related environmental sciences, lcsh:RC705-779, BARRIERS, business.industry, Public Health, Environmental and Occupational Health, FRESH AIR collaborators, lcsh:Diseases of the respiratory system, Solid fuel, DIFFUSION, Commerce, ENABLERS, business, CLEAN FUELS, HOUSEHOLD AIR-POLLUTION
Abstract

We most welcome the comment by Thakur, van Schayck and Boudewijns on our article on the effects and acceptability of implementing improved cookstoves. Adoption rates of improved cookstoves by local communities are often strikingly low. The authors underline the urge to advance cookstove implementation strategies, and reinforce the approach used in the FRESH AIR project. They highlight several important factors to increase adoption success and call for further research on the topic. We want to build on this comment by reflecting on decades of substantial discrepancies between the disappointing adoption rates of improved cookstoves, and the subsequent failure to adapt implementation strategies accordingly. We argue that it is not necessarily the lack of evidence that impedes the success of implementation strategies for improved cookstoves. Moreover, it is the lack of use of the evidence by implementors. We propose several ideas for overcoming this evidence-to-practice gap.

Published
2020
Full Text
View/download PDF

3. The socioeconomic burden of chronic lung disease in low-resource settings across the globe – an observational FRESH AIR study

Author

Brakema, E.A., Tabyshova, A., Kleij, R.M.J.J. van der, Sooronbaev, T., Lionis, C., Anastasaki, M., An, P.L., Nguyen, L.T., Kirenga, B., Walusimbi, S., Postma, M.J., Chavannes, N.H., J.F.M. van boven, Akylbekov, A., Barton, A., Bertsias, A., Binh, P.D.U., J.F. van boven, Burges, D., Cartwright, L., Chatzea, V.E., Cragg, L., Dang, T.N., Dautov, I., Emilov, B., Ferarrio, I., Gemert, F.A. van, Hedrick, B., Hong, L.H.T.C., Hopkinson, N., Isaeva, E., Jones, R., Jong, C. de, Kampen, S. van, Katagira, W., Kjaergaard, J., Kleij, R.M. van der, Kocks, J., Lan, L.T.T., Linh, T.T.D., Loan, K.X., Mademilov, M., McEwen, A., Musinguzi, P., Nantanda, R., Ndeezi, G., Papadakis, S., Pinnock, H., Pooler, J., Poot, C.C., Poulsen, A., Powell, P., Quynh, N.N., Reventlow, S., Sifaki-Pistolla, D., Singh, S., Sousa, J.C. de, Stout, J., Ostergaard, M.S., Tsiligianni, I., Tuan, T.D., Tumwine, J., L.T. van, Vinh, N.N., Warren, L., Williams, S., FRESH AIR Collaborators, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), PharmacoTherapy, -Epidemiology and -Economics, Methods in Medicines evaluation & Outcomes research (M2O), and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
Lung Diseases, Male, Work, IMPACT, Respiratory System, Global Health, 0302 clinical medicine, Cost of Illness, Quality of life, QUALITY-OF-LIFE, Uganda, 030212 general & internal medicine, 1102 Cardiorespiratory Medicine and Haematology, ACTIVITY IMPAIRMENT, OUTCOMES, COPD, Greece, 1. No poverty, Low-income population, ASSOCIATION, Middle Aged, WORK PRODUCTIVITY, Obstructive lung disease, Chronic respiratory disease, 3. Good health, WPAI, Vietnam, Chronic lung disease, Absenteeism, Health Resources, Female, HEALTH, Adult, medicine.medical_specialty, OBSTRUCTIVE PULMONARY-DISEASE, Young Adult, 03 medical and health sciences, Environmental health, medicine, Humans, Kyrgyzstan, Poverty, Socioeconomic status, Aged, lcsh:RC705-779, Health economics, business.industry, Research, Public health, 1103 Clinical Sciences, lcsh:Diseases of the respiratory system, medicine.disease, Household air pollution, Cross-Sectional Studies, Social Class, 030228 respiratory system, Chronic Disease, Presenteeism, ASTHMA CONTROL, Low-resource countries, business
Abstract

Background Low-resource settings are disproportionally burdened by chronic lung disease due to early childhood disadvantages and indoor/outdoor air pollution. However, data on the socioeconomic impact of respiratory diseases in these settings are largely lacking. Therefore, we aimed to estimate the chronic lung disease-related socioeconomic burden in diverse low-resource settings across the globe. To inform governmental and health policy, we focused on work productivity and activity impairment and its modifiable clinical and environmental risk factors. Methods We performed a cross-sectional, observational FRESH AIR study in Uganda, Vietnam, Kyrgyzstan, and Greece. We assessed the chronic lung disease-related socioeconomic burden using validated questionnaires among spirometry-diagnosed COPD and/or asthma patients (total N = 1040). Predictors for a higher burden were studied using multivariable linear regression models including demographics (e.g. age, gender), health parameters (breathlessness, comorbidities), and risk factors for chronic lung disease (smoking, solid fuel use). We applied identical models per country, which we subsequently meta-analyzed. Results Employed patients reported a median [IQR] overall work impairment due to chronic lung disease of 30% [1.8–51.7] and decreased productivity (presenteeism) of 20.0% [0.0–40.0]. Remarkably, work time missed (absenteeism) was 0.0% [0.0–16.7]. The total population reported 40.0% [20.0–60.0] impairment in daily activities. Breathlessness severity (MRC-scale) (B = 8.92, 95%CI = 7.47–10.36), smoking (B = 5.97, 95%CI = 1.73–10.22), and solid fuel use (B = 3.94, 95%CI = 0.56–7.31) were potentially modifiable risk factors for impairment. Conclusions In low-resource settings, chronic lung disease-related absenteeism is relatively low compared to the substantial presenteeism and activity impairment. Possibly, given the lack of social security systems, relatively few people take days off work at the expense of decreased productivity. Breathlessness (MRC-score), smoking, and solid fuel use are potentially modifiable predictors for higher impairment. Results warrant increased awareness, preventive actions and clinical management of lung diseases in low-resource settings from health policymakers and healthcare workers.

Published
2019
Full Text
View/download PDF

4. Effects and acceptability of implementing improved cookstoves and heaters to reduce household air pollution: a FRESH AIR study

Author

Gemert, F. van, Jong, C. de, Kirenga, B., Musinguzi, P., Buteme, S., Sooronbaev, T., Tabyshova, A., Emilov, B., Mademilov, M., An, P.L., Quynh, N.N., Dang, T.N., Hong, L.H.T.C., Chartier, R., Brakema, E.A., J.F.M. van boven, Kocks, J., Nantanda, R., Katagira, W., Ndeezi, G., Tumwine, J., Walusimbi, S., Akylbekov, A., Binh, P.D.U., Tuan, T.D., Lan, L.T.T., Linh, T.T.D., Loan, K.X., L.T. van, Vinh, N.N., Chavannes, N.H., Kleij, R.M.J.J. van der, Poot, C., Anastasaki, M., Bertsias, A., Chatzea, V.E., Lionis, C., Papadakis, S., Sifaki-Pistolla, D., Tsiligianni, I., Singh, S., Burges, D., Hedrick, B., Stout, J., Warren, L., Ferarrio, I., Powell, P., Barton, A., Cartwright, L., Kampen, S. van, Jones, R., Pooler, J., Poulsen, A., Kjaergaard, J., Hopkinson, N., Cragg, L., Pinnock, H., Williams, S., McEwen, A., Reventlow, S., Stubbe-Ostergaard, M., Postma, M.J., Sousa, J.C. de, FRESH AIR, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Research Institute for Asthma and COPD (GRIAC), PharmacoTherapy, -Epidemiology and -Economics, Microbes in Health and Disease (MHD), Methods in Medicines evaluation & Outcomes research (M2O), and Universidade do Minho

Subjects
Male, Rural Population, Epidemiology, air pollution, Air pollution, medicine.disease_cause, Medicina Clínica [Ciências Médicas], 0302 clinical medicine, Chest infections, Who recommendations, Quantitative assessment, Medicine, awareness, middle income country, Uganda, Cooking, 030212 general & internal medicine, Child, Household Articles, Respiratory Tract Infections, child, Family Characteristics, Public health, quantitative analysis, adult, Incidence, Viet nam, Vietnam, Viet Nam, Air Pollution, Indoor, Child, Preschool, Scale (social sciences), Female, Adult, Pulmonary and Respiratory Medicine, comparative effectiveness, chest infection, Article, 03 medical and health sciences, Fresh air, Environmental health, Humans, controlled study, human, rural population, Kyrgyzstan, Ciências Médicas::Medicina Clínica, lcsh:RC705-779, Science & Technology, business.industry, practice guideline, Public Health, Environmental and Occupational Health, lcsh:Diseases of the respiratory system, dyspnea, household, 030228 respiratory system, Who guidelines, business
Abstract

The objective was to evaluate the effectiveness and acceptability of locally tailored implementation of improved cookstoves/heaters in low- and middle-income countries. This interventional implementation study among 649 adults and children living in rural communities in Uganda, Vietnam and Kyrgyzstan, was performed after situational analyses and awareness programmes. Outcomes included household air pollution (PM2.5 and CO), self-reported respiratory symptoms (with CCQ and MRC-breathlessness scale), chest infections, school absence and intervention acceptability. Measurements were conducted at baseline, 2 and 6-12 months after implementing improved cookstoves/heaters. Mean PM2.5 values decrease by 31% (to 95.1 µg/m3) in Uganda (95%CI 71.5-126.6), by 32% (to 31.1 µg/m3) in Vietnam (95%CI 24.5-39.5) and by 65% (to 32.4 µg/m3) in Kyrgyzstan (95%CI 25.7-40.8), but all remain above the WHO guidelines. CO-levels remain below the WHO guidelines. After intervention, symptoms and infections diminish significantly in Uganda and Kyrgyzstan, and to a smaller extent in Vietnam. Quantitative assessment indicates high acceptance of the new cookstoves/heaters. In conclusion, locally tailored implementation of improved cookstoves/heaters is acceptable and has considerable effects on respiratory symptoms and indoor pollution, yet mean PM2.5 levels remain above WHO recommendations., European Union’s Horizon 2020 programme under grant agreement no. 680997, TRIAL ID NTR5759, http://www.trialregister.nl/trialreg/admin/rctsearch.asp?Term=23332. The devices, measuring the personal HAP, were funded by Netherlands Enterprise Agency (RVO)

Published
2019
Full Text
View/download PDF

5. COPD's early origins in low-and-middle income countries: what are the implications of a false start?

Author

Brakema, E.A., Gemert, F.A. van, Kleij, R.M.J.J. van der, Salvi, S., Puhan, M., Chavannes, N.H., An, P.L., Anastasaki, M., Akmatalieva, M., Akylbekov, A., Barton, A., Bertsias, A., Binh, P.D.U., J.F.M. van boven, Burges, D., Cartwright, L., Chatzea, V.E., Cragg, L., Dang, T.N., Dautov, I., Emilov, B., Ferarrio, I., Hedrick, B., Hong, L.H.T.C., Hopkinson, N., Isaeva, E., Jones, R., Jong, C. de, Kampen, S. van, Katagira, W., Kirenga, B., Kjaergaard, J., Kocks, J., Lan, L.T.T., Linh, T.T.D., Lionis, C., Loan, K.X., Mademilov, M., McEwen, A., Musinguzi, P., Nantanda, R., Ndeezi, G., Papadakis, S., Pinnock, H., Pooler, J., Poot, C., Postma, M.J., Poulsen, A., Powell, P., Quynh, N.N., Reventlow, S., Sifaki-Pistolla, D., Singh, S., Sooronbaev, T., Sousa, J.C. de, Stout, J., Stubbe-Ostergaard, M., Tabyshova, A., Tsiligianni, I., Tuan, T.D., Tumwine, J., L.T. van, Vinh, N.N., Walusimbi, S., Warren, L., Williams, S., FRESH AIR Collaborators, University of Zurich, Brakema, E A, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Research Institute for Asthma and COPD (GRIAC), Microbes in Health and Disease (MHD), and PharmacoTherapy, -Epidemiology and -Economics

Subjects
Pulmonary and Respiratory Medicine, Respiratory System, MEDLINE, Pulmonary disease, Developing country, 610 Medicine & health, Vulnerable Populations, OBSTRUCTIVE PULMONARY-DISEASE, Pulmonary Disease, Chronic Obstructive, POLLUTION, Risk Factors, Environmental health, General & Internal Medicine, medicine, Humans, Developing Countries, Lung function, lcsh:RC705-779, COPD, Science & Technology, Primary Health Care, business.industry, Comment, Public Health, Environmental and Occupational Health, FRESH AIR collaborators, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2739 Public Health, Environmental and Occupational Health, lcsh:Diseases of the respiratory system, medicine.disease, False start, LUNG-FUNCTION, LIFE, Socioeconomic Factors, 2740 Pulmonary and Respiratory Medicine, Low and middle income countries, HEALTH, business, Life Sciences & Biomedicine
Published
2019
Full Text
View/download PDF

9. Independent Medical Service

Author

Eade, W., Savery, H., Shimmin, C. D. G. L., Reichenfeld, H. F., Wainwright, A. J., Jones, P. G., Midya, T. S., Burges, D. C. L., Smallbone, D. F., Holliday, D. B., Smith, Gilbert R., and Targett, D. H.

Published
1965

11. Independent Medical Service.

Author

Reichenfeld, H. F., Wainwright, A. J., Jones, P. G., Midya, T. S., Burges, D. C. L., Smallbone, D. F., Holliday, D. B., Smith, Gilbert R., and Targett, D. H.

Published
1965
Full Text
View/download PDF

12. Exome sequencing of a multigenerational human pedigree.

Author

Hedges DJ, Burges D, Powell E, Almonte C, Huang J, Young S, Boese B, Schmidt M, Pericak-Vance MA, Martin E, Zhang X, Harkins TT, and Züchner S

Subjects
Female, Genotype, Humans, Inheritance Patterns genetics, Male, Polymorphism, Single Nucleotide genetics, Exons genetics, Family Characteristics, Genome, Human genetics, Pedigree, Sequence Analysis, DNA
Abstract

Over the next few years, the efficient use of next-generation sequencing (NGS) in human genetics research will depend heavily upon the effective mechanisms for the selective enrichment of genomic regions of interest. Recently, comprehensive exome capture arrays have become available for targeting approximately 33 Mb or approximately 180,000 coding exons across the human genome. Selective genomic enrichment of the human exome offers an attractive option for new experimental designs aiming to quickly identify potential disease-associated genetic variants, especially in family-based studies. We have evaluated a 2.1 M feature human exome capture array on eight individuals from a three-generation family pedigree. We were able to cover up to 98% of the targeted bases at a long-read sequence read depth of > or = 3, 86% at a read depth of > or = 10, and over 50% of all targets were covered with > or = 20 reads. We identified up to 14,284 SNPs and small indels per individual exome, with up to 1,679 of these representing putative novel polymorphisms. Applying the conservative genotype calling approach HCDiff, the average rate of detection of a variant allele based on Illumina 1 M BeadChips genotypes was 95.2% at > or = 10x sequence. Further, we propose an advantageous genotype calling strategy for low covered targets that empirically determines cut-off thresholds at a given coverage depth based on existing genotype data. Application of this method was able to detect >99% of SNPs covered > or = 8x. Our results offer guidance for "real-world" applications in human genetics and provide further evidence that microarray-based exome capture is an efficient and reliable method to enrich for chromosomal regions of interest in next-generation sequencing experiments.

Published
2009
Full Text
View/download PDF

13. Bacillus subtilis ORF yybQ encodes a manganese-dependent inorganic pyrophosphatase with distinctive properties: the first of a new class of soluble pyrophosphatase?

Author

Young TW, Kuhn NJ, Wadeson A, Ward S, Burges D, and Cooke GD

Subjects
Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA Primers genetics, Escherichia coli genetics, Evolution, Molecular, Gene Expression, Genes, Bacterial, Humans, Inorganic Pyrophosphatase, Manganese metabolism, Molecular Sequence Data, Molecular Weight, Open Reading Frames, Protein Conformation, Pyrophosphatases classification, Pyrophosphatases metabolism, Sequence Homology, Amino Acid, Solubility, Species Specificity, Bacillus subtilis enzymology, Bacillus subtilis genetics, Pyrophosphatases genetics
Abstract

The N-terminal 15 amino acids of the major protein associated with inorganic pyrophosphatase activity in Bacillus subtilis WB600 are identical to those of B. subtilis ORF yybQ. This ORF was amplified from B. subtilis WB600 DNA by PCR and cloned into an overexpression vector in Escherichia coli. Induction of overexpression produced a soluble protein of 34,000 Da by SDS-PAGE and by matrix-assisted laser desorption and ionization mass spectrometry. The overexpressed protein had a high specific activity for the hydrolysis of magnesium pyrophosphate, and was specifically and reversibly activated by Mn2+ ions. These properties are identical to those of inorganic pyrophosphatase purified from B. subtilis WB600. No significant similarity was found between the derived sequence of the B. subtilis yybQ-encoded protein and published sequences of identified inorganic pyrophosphatases of Eukarya, Bacteria or Archaea domains. However, there is significant similarity to three putative proteins of unknown function from the archaea Methanococcus jannaschii and Archaeoglobus fulgidus, and from Streptococcus gordonii. The genomes of B. subtilis, M. jannaschii and A. fulgidus do not contain sequences similar to those of hitherto known soluble inorganic pyrophosphatases. The present findings, together with a survey of the properties of inorganic pyrophosphatases from 38 different sources, suggest that the B. subtilis yybQ-encoded protein is the first fully characterized member of a new class of inorganic pyrophosphatase.

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results