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8 results on '"Bushnev, Anatoliy"'

1. Expanding the toolbox of metabolically stable lipid prodrug strategies

Author

Toti, Kiran S., primary, Pribut, Nicole, additional, D’Erasmo, Michael, additional, Dasari, Madhuri, additional, Sharma, Savita K., additional, Bartsch, Perry W., additional, Burton, Samantha L., additional, Gold, Hannah B., additional, Bushnev, Anatoliy, additional, Derdeyn, Cynthia A., additional, Basson, Adriaan E., additional, Liotta, Dennis C., additional, and Miller, Eric J., additional

Published
2023
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2. Sphingolipid Analogues Inhibit Development of Malaria Parasites

Author

Meyer, Esmeralda V. S., primary, Holt, Jason J., additional, Girard, Kathryn R., additional, Ballie, Mark T., additional, Bushnev, Anatoliy S., additional, Lapp, Stacey, additional, Menaldino, David S., additional, Arrendale, Richard F., additional, Reddy, G. Prabhakar, additional, Evers, Taylor J., additional, Howard, Randy B., additional, Culver, Deborah G., additional, Liotta, Dennis C., additional, Galinski, Mary R., additional, and Natchus, Michael G., additional

Published
2011
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3. Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer

Author

Symolon, Holly, primary, Bushnev, Anatoliy, additional, Peng, Qiong, additional, Ramaraju, Harsha, additional, Mays, Suzanne G., additional, Allegood, Jeremy C., additional, Pruett, Sarah T., additional, Sullards, M. Cameron, additional, Dillehay, Dirck L., additional, Liotta, Dennis C., additional, and Merrill, Alfred H., additional

Published
2011
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4. Novel Synthesis and Biological Evaluation of Enigmols as Therapeutic Agents for Treating Prostate Cancer

Author

Garnier-Amblard, Ethel C., primary, Mays, Suzanne G., additional, Arrendale, Richard F., additional, Baillie, Mark T., additional, Bushnev, Anatoliy S., additional, Culver, Deborah G., additional, Evers, Taylor J., additional, Holt, Jason J., additional, Howard, Randy B., additional, Liebeskind, Lanny S., additional, Menaldino, David S., additional, Natchus, Michael G., additional, Petros, John A., additional, Ramaraju, Harsha, additional, Reddy, G. Prabhakar, additional, and Liotta, Dennis C., additional

Published
2011
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7. Thematic Review Series: Sphingolipids.Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols*

Author

Pruett, Sarah T., Bushnev, Anatoliy, Hagedorn, Kerri, Adiga, Madhura, Haynes, Christopher A., Sullards, M. Cameron, Liotta, Dennis C., and Merrill, Alfred H.

Abstract

“Sphingosin” was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of “lipides derived from sphingosine as sphingolipides.” This category of amino alcohols is now known to encompass hundreds of compounds that are referred to as sphingoid bases and sphingoid base-like compounds, which vary in chain length, number, position, and stereochemistry of double bonds, hydroxyl groups, and other functionalities. Some have especially intriguing features, such as the tail-to-tail combination of two sphingoid bases in the α,ω-sphingoids produced by sponges. Most of these compounds participate in cell structure and regulation, and some (such as the fumonisins) disrupt normal sphingolipid metabolism and cause plant and animal disease. Many of the naturally occurring and synthetic sphingoid bases are cytotoxic for cancer cells and pathogenic microorganisms or have other potentially useful bioactivities; hence, they offer promise as pharmaceutical leads. This thematic review gives an overview of the biodiversity of the backbones of sphingolipids and the broader field of naturally occurring and synthetic sphingoid base-like compounds.

Published
2008
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8. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols.

Author

Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, and Merrill AH Jr

Subjects
Animals, Humans, Lipids chemistry, Oxidoreductases antagonists & inhibitors, Serine C-Palmitoyltransferase antagonists & inhibitors, Serine C-Palmitoyltransferase metabolism, Sphingolipids chemistry, Sphingosine analogs & derivatives, Amino Alcohols chemistry, Sphingosine chemistry
Abstract

"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now known to encompass hundreds of compounds that are referred to as sphingoid bases and sphingoid base-like compounds, which vary in chain length, number, position, and stereochemistry of double bonds, hydroxyl groups, and other functionalities. Some have especially intriguing features, such as the tail-to-tail combination of two sphingoid bases in the alpha,omega-sphingoids produced by sponges. Most of these compounds participate in cell structure and regulation, and some (such as the fumonisins) disrupt normal sphingolipid metabolism and cause plant and animal disease. Many of the naturally occurring and synthetic sphingoid bases are cytotoxic for cancer cells and pathogenic microorganisms or have other potentially useful bioactivities; hence, they offer promise as pharmaceutical leads. This thematic review gives an overview of the biodiversity of the backbones of sphingolipids and the broader field of naturally occurring and synthetic sphingoid base-like compounds.

Published
2008
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