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1. Corrigendum: The effects of an acceptance and commitment-informed interdisciplinary rehabilitation program for chronic airway diseases on health status and psychological symptoms

Author

Giusti, Emanuele Maria, primary, Papazian, Barbara, additional, Manna, Chiara, additional, Giussani, Valentina, additional, Perotti, Milena, additional, Castelli, Francesca, additional, Battaglia, Silvia, additional, Galli, Pietro, additional, Rossi, Agnese, additional, Re, Valentina, additional, Goulene, Karine, additional, Castelnuovo, Gianluca, additional, and Stramba-Badiale, Marco, additional

Published
2023
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4. The Effects of an Acceptance and Commitment-Informed Interdisciplinary Rehabilitation Program for Chronic Airway Diseases on Health Status and Psychological Symptoms

Author

Giusti, Emanuele Maria, primary, Papazian, Barbara, additional, Manna, Chiara, additional, Giussani, Valentina, additional, Perotti, Milena, additional, Castelli, Francesca, additional, Battaglia, Silvia, additional, Galli, Pietro, additional, Rossi, Agnese, additional, Re, Valentina, additional, Goulene, Karine, additional, Castelnuovo, Gianluca, additional, and Stramba-Badiale, Marco, additional

Published
2022
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5. Appropriateness of oral anticoagulant therapy prescription and its associated factors in hospitalized older people with atrial fibrillation

Author

Franchi, Carlotta, Antoniazzi, Stefania, Proietti, Marco, Nobili, Alessandro, Mannucci, Pier Mannuccio, Santalucia, Paola, Monzani, Valter, Marcucci, Maura, Bosari, Silvano, Brignolo, Barbara, Nicolis, Enrico, Ardoino, Ilaria, Fenoglio, Luigi M., Melchio, Remo, Fabris, Fabrizio, Sartori, Maria Teresa, Manfredini, Roberto, De Giorgi, Alfredo, Fabbian, Fabio, Biolo, Gianni, Zanetti, Michela, Altamura, Nicola, Sabbà, Carlo, Suppressa, Patrizia, Bandiera, Francesco, Usai, Carlo, Murialdo, Giovanni, Fezza, Francesca, Marra, Alessio, Castelli, Francesca, Cattaneo, Federico, Beccati, Valentina, di Minno, Giovanni, Tufano, Antonella, Contaldi, Paola, Lupattelli, Graziana, Bianconi, Vanessa, Cappellini, Domenica, Cinzia, Hu, Minonzio, Francesca, Fargion, Silvia, Burdick, Larry, Francione, Paolo, Peyvandi, Flora, Rossio, Raffaella, Colombo, Giulia, Ceriani, Giuliana, Lucchi, Tiziano, Manfellotto, Dario, Caridi, Irene, Corazza, Gino Roberto, Miceli, Emanuela, Padula, Donatella, Fraternale, Giacomo, Guasti, Luigina, Squizzato, Alessandro, Maresca, Andrea, Liberato, Nicola Lucio, Tognin, Tiziana, Rozzini, Renzo, Bellucci, Francesco Baffa, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Dore, Maurizio, Mete, Francesca, Gino, Miriam, Franceschi, Francesco, Gabrielli, Maurizio, Perticone, Francesco, Perticone, Maria, Bertolotti, Marco, Mussi, Chiara, Borghi, Claudio, Strocchi, Enrico, Durazzo, Marilena, Fornengo, Paolo, Dallegri, Franco, Ottonello, Luciano Carlo, Salam, Kassem, Caserza, Lara, Barbagallo, Mario, Di Bella, Giovanna, Annoni, Giorgio, Bruni, Adriana Antonella, Odetti, Patrizio, Nencioni, Alessio, Monacelli, Fiammetta, Napolitano, Armando, Brucato, Antonio, Valenti, Anna, Castellino, Pietro, Zanoli, Luca, Mazzeo, Marco, Franchi, Carlotta, Antoniazzi, Stefania, Proietti, Marco, Nobili, Alessandro, Mannucci, Pier Mannuccio, Santalucia, Paola, Monzani, Valter, Marcucci, Maura, Bosari, Silvano, Brignolo, Barbara, Nicolis, Enrico, Ardoino, Ilaria, Fenoglio, Luigi M., Melchio, Remo, Fabris, Fabrizio, Sartori, Maria Teresa, Manfredini, Roberto, De Giorgi, Alfredo, Fabbian, Fabio, Biolo, Gianni, Zanetti, Michela, Altamura, Nicola, Sabbà, Carlo, Suppressa, Patrizia, Bandiera, Francesco, Usai, Carlo, Murialdo, Giovanni, Fezza, Francesca, Marra, Alessio, Castelli, Francesca, Cattaneo, Federico, Beccati, Valentina, di Minno, Giovanni, Tufano, Antonella, Contaldi, Paola, Lupattelli, Graziana, Bianconi, Vanessa, Cappellini, Domenica, Hu, Cinzia, Minonzio, Francesca, Fargion, Silvia, Burdick, Larry, Francione, Paolo, Peyvandi, Flora, Rossio, Raffaella, Colombo, Giulia, Ceriani, Giuliana, Lucchi, Tiziano, Manfellotto, Dario, Caridi, Irene, Corazza, Gino Roberto, Miceli, Emanuela, Padula, Donatella, Fraternale, Giacomo, Guasti, Luigina, Squizzato, Alessandro, Maresca, Andrea, Liberato, Nicola Lucio, Tognin, Tiziana, Rozzini, Renzo, Bellucci, Francesco Baffa, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Dore, Maurizio, Mete, Francesca, Gino, Miriam, Franceschi, Francesco, Gabrielli, Maurizio, Perticone, Francesco, Perticone, Maria, Bertolotti, Marco, Mussi, Chiara, Borghi, Claudio, Strocchi, Enrico, Durazzo, Marilena, Fornengo, Paolo, Dallegri, Franco, Ottonello, Luciano Carlo, Salam, Kassem, Caserza, Lara, Barbagallo, Mario, Di Bella, Giovanna, Annoni, Giorgio, Bruni, Adriana Antonella, Odetti, Patrizio, Nencioni, Alessio, Monacelli, Fiammetta, Napolitano, Armando, Brucato, Antonio, Valenti, Anna, Castellino, Pietro, Zanoli, Luca, Mazzeo, Marco, Franchi, C, Antoniazzi, S, Proietti, M, Nobili, A, Mannucci, P, Santalucia, P, Monzani, V, Marcucci, M, Bosari, S, Brignolo, B, Nicolis, E, Ardoino, I, Fenoglio, L, Melchio, R, Fabris, F, Sartori, M, Manfredini, R, De Giorgi, A, Fabbian, F, Biolo, G, Zanetti, M, Altamura, N, Sabbà, C, Suppressa, P, Bandiera, F, Usai, C, Murialdo, G, Fezza, F, Marra, A, Castelli, F, Cattaneo, F, Beccati, V, di Minno, G, Tufano, A, Contaldi, P, Lupattelli, G, Bianconi, V, Cappellini, D, Hu, C, Minonzio, F, Fargion, S, Burdick, L, Francione, P, Peyvandi, F, Rossio, R, Colombo, G, Ceriani, G, Lucchi, T, Manfellotto, D, Caridi, I, Corazza, G, Miceli, E, Padula, D, Fraternale, G, Guasti, L, Squizzato, A, Maresca, A, Liberato, N, Tognin, T, Rozzini, R, Bellucci, F, Muscaritoli, M, Molfino, A, Petrillo, E, Dore, M, Mete, F, Gino, M, Franceschi, F, Gabrielli, M, Perticone, F, Perticone, M, Bertolotti, M, Mussi, C, Borghi, C, Strocchi, E, Durazzo, M, Fornengo, P, Dallegri, F, Ottonello, L, Salam, K, Caserza, L, Barbagallo, M, Di Bella, G, Annoni, G, Bruni, A, Odetti, P, Nencioni, A, Monacelli, F, Napolitano, A, Brucato, A, Valenti, A, Castellino, P, Zanoli, L, and Mazzeo, M

Subjects
Male, Oral, appropriateness of prescription, appropriateness of prescription, atrial fibrillation, internal medicine, geriatric wards, older patients, oral anticoagulant, Socio-culturale, Administration, Oral, Hemorrhage, Inappropriate Prescribing, Drug Prescriptions, internal medicine and geriatric ward, Dose-Response Relationship, older patient, Risk Factors, oral anticoagulant, 80 and over, Humans, atrial fibrillation, Pharmacology (medical), Prospective Studies, Aged, Retrospective Studies, Aged, 80 and over, Pharmacology, geriatric wards, Dose-Response Relationship, Drug, Settore MED/09 - MEDICINA INTERNA, Age Factors, Anticoagulants, internal medicine and geriatric wards, Original Articles, older patients, Stroke, internal medicine, Administration, Female, Drug
Abstract

Aims: Although oral anticoagulants (OACs) are effective in preventing stroke in older people with atrial fibrillation (AF), they are often underused in this particularly high-risk population. The aim of the present study was to assess the appropriateness of OAC prescription and its associated factors in hospitalized patients aged 65years or older. Methods: Data were obtained from the retrospective phase of Simulation-based Technologies to Improve the Appropriate Use of Oral Anticoagulants in Hospitalized Elderly Patients With Atrial Fibrillation (SIM-AF) study, held in 32 Italian internal medicine and geriatric wards. The appropriateness of OAC prescription was assessed, grouping patients in those who were and were not prescribed OACs at hospital discharge. Multivariable logistic regression was used to establish factors independently associated with the appropriateness of OAC prescription. Results: A total of 328 patients were included in the retrospective phase of the study. Of these, almost 44% (N = 143) were inappropriately prescribed OACs, being mainly underprescribed or prescribed an inappropriate antithrombotic drug (N = 88). Among the patients prescribed OACs (N=221), errors in the prescribed doses were the most frequent cause of inappropriate use (N=55). Factors associated with a higher degree of patient frailty were inversely associated with the appropriateness of OAC prescription. Conclusions: In hospitalized older patients with AF, there is still a high prevalence of inappropriate OAC prescribing. Characteristics usually related to frailty are associated with the inappropriate prescribing. These findings point to the need for targeted interventions designed for internists and geriatricians, aimed at improving the appropriate prescribing of OACs in this complex and high-risk population.

Published
2018

6. Appropriateness of prescription of oral anticoagulant therapy in acutely hospitalized older people with atrial fibrillation. Secondary analysis of the SIM-AF cluster randomized clinical trial

Author

Stefania, Antoniazzi, Ilaria, Ardoino, Marco, Proietti, Valter, Monzani, Pier Mannuccio Mannucci, Alessandro, Nobili, Carlotta, Franchi, Paola, Santalucia, Maura, Marcucci, Silvano, Bosari, Barbara, Brignolo, Enrico, Nicolis, Fenoglio, Luigi M., Remo, Melchio, Fabrizio, Fabris, Maria Teresa Sartori, Roberto, Manfredini, Alfredo De Giorgi, Fabio, Fabbian, Gianni, Biolo, Michela, Zanetti, Nicola, Altamura, Carlo, Sabbà, Patrizia, Suppressa, Francesco, Bandiera, Carlo, Usai, Murialdo, Giovanni, Fezza, Francesca, Marra, Alessio, Castelli, Francesca, Cattaneo, Federico, Beccati, Valentina, Giovanni di Minno, Antonella, Tufano, Paola, Contaldi, Graziana, Lupattelli, Vanessa, Bianconi, Domenica, Cappellini, Cinzia, Hu, Francesca, Minonzio, Silvia, Fargion, Larry, Burdick, Paolo, Francione, Flora, Peyvandi, Raffaella, Rossio, Giulia, Colombo, Giuliana, Ceriani, Tiziano, Lucchi, Dario, Manfellotto, Irene, Caridi, Gino Roberto Corazza, Emanuela, Miceli, Donatella, Padula, Giacomo, Fraternale, Luigina, Guasti, Alessandro, Squizzato, Andrea, Maresca, Nicola Lucio Liberato, Tiziana, Tognin, Renzo, Rozzini, Francesco Baffa Bellucci, Maurizio, Muscaritoli, Alessio, Molfino, Enrico, Petrillo, Maurizio, Dore, Paolo, Raviolo, Francesca, Mete, Miriam, Gino, Francesco, Franceschi, Maurizio, Gabrielli, Francesco, Perticone, Maria, Perticone, Marco, Bertolotti, Chiara, Mussi, Claudio, Borghi, Enrico, Strocchi, Marilena, Durazzo, Paolo, Fornengo, Claudia, Ruatta, Dallegri, Franco, Ottonello, LUCIANO CARLO, Salam, Kassem, Caserza, Lara, Mario, Barbagallo, Giovanna Di Bella, Giorgio, Annoni, Adriana Antonella Bruni, Odetti, Patrizio, Nencioni, Alessio, Monacelli, Fiammetta, Armando, Napolitano, Antonio, Brucato, Anna, Valenti, Pietro, Castellino, Luca, Zanoli, and Marco, Mazzeo

Subjects
Male, Antiplatelet drug, appropriateness of prescription, Health Services for the Aged, medicine.medical_treatment, Administration, Oral, Inappropriate Prescribing, 030226 pharmacology & pharmacy, law.invention, 0302 clinical medicine, Patient Admission, Randomized controlled trial, law, Risk Factors, Atrial Fibrillation, Prevalence, Pharmacology (medical), 030212 general & internal medicine, Prospective Studies, Practice Patterns, Physicians', LS4_7, Aged, 80 and over, Clinical pharmacology, prescribing, Atrial fibrillation, Patient Discharge, Stroke, Female, drug utilization, medicine.medical_specialty, Socio-culturale, Hemorrhage, Drug Prescriptions, 03 medical and health sciences, Internal medicine, medicine, Humans, Medical prescription, Aged, Pharmacology, clinical trials, business.industry, Anticoagulants, Odds ratio, Original Articles, medicine.disease, Confidence interval, appropriateness of prescription, clinical pharmacology, clinical trials, drug utilization, medication errors, prescribing, Clinical trial, medication errors, clinical pharmacology, business
Abstract

Aims To assess the appropriateness of oral anticoagulant (OAC) prescription and its associated factors in acutely hospitalized elderly patients. Methods Data were obtained from the prospective phase of SIM-AF (SIMulation-based technologies to improve the appropriate use of oral anticoagulants in hospitalized elderly patients with Atrial Fibrillation) randomized controlled trial, aimed to test whether an educational intervention improved OAC prescription, compared to current clinical practice, in internal medicine wards. In this secondary analysis, appropriateness of OAC prescription was assessed at hospital admission and discharge. Results For 246 patients, no significant differences were found between arms (odds ratio 1.38, 95% confidence interval [CI] 0.84-2.28) in terms of appropriateness of OAC prescription. Globally, 92 patients (37.4%, 95% CI = 31.6-43.6%) were inappropriately prescribed or not prescribed at hospital discharge. Among 51 patients inappropriately prescribed, 82% showed errors on dosage, being mainly under-dosed (n = 29, 56.9%), and among 41 inappropriately not prescribed, 98% were taking an antiplatelet drug. Factors independently associated with a lower probability of appropriateness at discharge were those related to a higher risk of bleeding (older age, higher levels of aspartate aminotransferase, history of falls, alcohol consumption) and antiplatelet prescription at admission. The prescription of OACs at admission was the strongest predictor of appropriateness at discharge (odds ratio = 7.43, 95% CI = 4.04-13.73). Conclusions A high proportion of hospitalized older patients with AF remains inappropriately prescribed or nonprescribed with OACs. The management of these patients at hospital admission is the strongest predictor of prescription appropriateness at discharge.

Published
2018

8. Sudden, unexpected death of a 15-year-old boy due to pancarditis

Author

Osculati, Antonio, Visonà, Silvia Damiana, Ventura, Francesco, Castelli, Francesca, and Andrello, Luisa

Subjects
Male, Adolescent, Rheumatic Heart Disease, sudden death, Pharyngitis, Myocarditis, pancarditis, rheumatic carditis, Death, Sudden, Cardiac, Streptococcal Infections, Humans, Clinical Case Report, Diagnostic Errors, Medical History Taking, Research Article
Abstract

Background: Generally, rheumatic heart disease is, today, sporadic in developed countries, even though it continues to be a major health hazard in the developing ones. It is also a very rare cause of sudden unexpected death. We report a case of a 15-year-old boy who suddenly died at home. Since 3 days he had presented fever and chest pain. The family physician had diagnosed bronchitis and treated the boy with amoxicillin. Methods: Seven hours after death, a forensic autopsy were performed . Before the autopsy, anamnesis and some circumstantial data were collected from the boy's parents. During the autopsy, samples for histological, toxicological and molecular examinations were collected. The samples for the histology (brain, hypophysis, heart and pericardium, lungs, spleen, liver, kidney, adrenal glands) were formalin fixed and paraffin embedded. Each section was stained with Hematoxylin-Eosin. Immunostaining was also performed, with anti-CD 68, anti-CD3, anti-CD 20, anti-myeloperoxidase. Microbiological cultures were performed on cardiac blood, myocardium, pericardial effusion and cerebrospinal fluid samples collected during autopsy. Blood specimens were also processed through PCR, in order to reveal the presence of Enteroviruses, Chickenpox virus, Epstein Barr virus. Also chemical-toxicological examinations for the detection of the main medications and drugs were performed on blood samples. Results: The anamnesis, collected before the autopsy, revealed an acute pharyngitis few weeks before. The autopsy, and the following histological and immunochemical examinations suggested an immunological etiology. The immunohistochemistry, showing a strong positivity of antiCD68 antibodies, integrated with clinical-anamnestic information, leads to hypothesize a rheumatic carditis. Conclusion: In light of this case, at least 3 main messages of great importance for the clinician can be deduced. First, an accurate anamnesis collected by the family physician could have led to the correct interpretation of the objective signs and the administration of an appropriate therapy. Second, a pharyngeal swab should be performed for cases involving sore throat in young children and adolescents, especially in cases involving repeated pharyngitis. Finally, apparently unremarkable findings revealed from objective examinations can be signs of a serious disease. Moreover, in some cases, these diseases can be lethal if they are not properly treated.

Published
2016

11. Il ciclo di vita dei veicoli

Author

Grimaldi, Andrea, Nencini, Dina, Castelli, Francesca Romana, Ghia, MARIA CLARA, and Spirito, Gianpaola

Subjects
il riciclo di veicoli e natanti, DROSSCAPES, i luoghi del riciclo, la Coda della cometa di Roma
Published
2014

12. Econometric models of financial risks

Author

Castelli, Francesca

Subjects
SECS-P/05 Econometria
Abstract

The goal of this dissertation is to use statistical tools to analyze specific financial risks that have played dominant roles in the US financial crisis of 2008-2009. The first risk relates to the level of aggregate stress in the financial markets. I estimate the impact of financial stress on economic activity and monetary policy using structural VAR analysis. The second set of risks concerns the US housing market. There are in fact two prominent risks associated with a US mortgage, as borrowers can both prepay or default on a mortgage. I test the existence of unobservable heterogeneity in the borrower's decision to default or prepay on his mortgage by estimating a multinomial logit model with borrower-specific random coefficients.

Published
2012
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