75 results on '"Cazzoletti, L"'
Search Results
2. Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: an observational longitudinal study
- Author
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Fratta Pasini, A. M., Stranieri, C., Ferrari, M., Garbin, U., Cazzoletti, L., Mozzini, C., Spelta, F., Peserico, D., and Cominacini, L.
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- 2020
- Full Text
- View/download PDF
3. Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III
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Nerpin, E., Olivieri, M., Gislason, T., Olin, A. C., Nielsen, R., Johannessen, A., Ferreira, D. S., Marcon, A., Cazzoletti, L., Accordini, S., Pin, I., Corsico, A., Demoly, P., Weyler, J., Nowak, D., Jõgi, R., Forsberg, Bertil, Zock, J.P., Sigsgaard, T., Heinric, J., Bono, R., Leynaert, B., Jarvis, D., Janson, C., Malinovschi, A., Nerpin, E., Olivieri, M., Gislason, T., Olin, A. C., Nielsen, R., Johannessen, A., Ferreira, D. S., Marcon, A., Cazzoletti, L., Accordini, S., Pin, I., Corsico, A., Demoly, P., Weyler, J., Nowak, D., Jõgi, R., Forsberg, Bertil, Zock, J.P., Sigsgaard, T., Heinric, J., Bono, R., Leynaert, B., Jarvis, D., Janson, C., and Malinovschi, A.
- Abstract
Introduction: The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective: To identify determinants of FENO in men and women without lung diseases. Method: FENO was validly measured in 3,881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease Results: Exhaled NO levels were 21.3% higher in men compared with women p<0.001. Being in the upper age quartile (60.3–67.6 years) men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7–48.3 years) p=0.02. Women in the two highest age quartiles (54.6–60.2 and 60.3–67.6 years) had 15.4 ppb (14.7, 16.2), p=0.03 and 16.4 ppb (15.6, 17.1), p=<0.001 higher FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (p<0.001) and 5% higher FENO levels in women (p=0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never‐smokers (p<0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non‐sensitized subjects 26% and 29%, p<0.001 for both. Conclusion & Clinical Relevance: FENO levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.
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- 2019
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- View/download PDF
4. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010
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de Marco R, Cappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, Braggion M, Bugiani M, Casali L, Cazzoletti L, Cerveri I, Fois AG, Girardi P, Locatelli F, Marcon A, Marinoni A, Panico MG, Pirina P, Villani S, Zanolin ME, Verlato G, the GEIRD Study Group: de Marco, R., Verlato, G., Zanolin, M., Accordini, S., Bortolami, O., Braggion, M., Cappa, V., Cazzoletti, L., Girardi, P., Locatelli, F., Marcon, A., Montoli, E., Rava, M., Vesentini, R., Ferrari, M., Donatelli, L., Posenato, C., Cascio, V., Perbellini, L., Olivieri, M., D'Amato, J., Donatini, E., Martinelli, M., Pignatti, P., Bombieri, C., Bettin, M., Trabetti, E., Poli, A., Nicolis, M., Sembeni, S., Antonicelli, L., Bonifazi, F., Attena, F., Galdo, V., Cerveri, I., Corsico, A., Albicini, F., Grosso, A., Marinoni, A., Villani, S., Ferretti, V., Casali, L., Miniucchi, A., Briziarelli, L., Marcarelli, M., Panico, M., Pirina, P., Fois, A., Becciu, F., Deledda, A., Spada, V., Bugiani, M., Carosso, A., Piccioni, P., Castiglioni, G., Bono, R., Tassinari, R., Romanazzi, V., Rolla, G., Heffler, E., Migliore, E., BELLIA, Vincenzo, BATTAGLIA, Salvatore, de Marco R, Cappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, Braggion M, Bugiani M, Casali L, Cazzoletti L, Cerveri I, Fois AG, Girardi P, Locatelli F, Marcon A, Marinoni A, Panico MG, Pirina P, Villani S, Zanolin ME, Verlato G, and the GEIRD Study Group: de Marco, R., Verlato, G., Zanolin, M., Accordini, S., Bortolami, O., Braggion, M., Cappa, V., Cazzoletti, L., Girardi, P., Locatelli, F., Marcon, A., Montoli, E., Rava, M., Vesentini, R., Ferrari, M., Donatelli, L., Posenato, C., Cascio, V., Perbellini, L., Olivieri, M., D'Amato, J., Donatini, E., Martinelli, M., Pignatti, P., Bombieri, C., Bettin, M., Trabetti, E., Poli, A., Nicolis, M., Sembeni, S., Antonicelli, L., Bonifazi, F., Attena, F., Galdo, V., Bellia, V., Battaglia, S., Cerveri, I., Corsico, A., Albicini, F., Grosso, A., Marinoni, A., Villani, S., Ferretti, V., Casali, L., Miniucchi, A., Briziarelli, L., Marcarelli, M., Panico, M., Pirina, P., Fois, A., Becciu, F., Deledda, A., Spada, V., Bugiani, M., Carosso, A., Piccioni, P., Castiglioni, G., Bono, R., Tassinari, R., Romanazzi, V., Rolla, G., Heffler, E., and Migliore, E.
- Subjects
Male ,Pediatrics ,Cross-sectional study ,95% CI 1.19-1.59) from 1998-2000 to 2007-2010 ,but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma ,Abstract The prevalence of asthma increased worldwide until the 1990s ,temporal trends ,Surveys and Questionnaires ,Epidemiology ,Surveys and Questionnaire ,Medicine ,asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy ,Young adult ,respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38 ,from 10.1% to 13.9% and from 16.8% to 25.8% ,education.field_of_study ,Allergic rhinitis ,Asthma ,Prevalence ,Temporal trends ,Wheezing ,medicine.diagnostic_test ,Smoking ,the median prevalence of current asthma ,allergic rhinitis, asthma, epidemiology, prevalence, temporal trends, wheezing ,Italy ,Abstract The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993 ,n=6,031) ,the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000 ,n=18,873) ,and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010 ,n=10,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis ,mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs ,symbols ,asthma prevalence has increased by 38% ,Female ,epidemiology ,Human ,Pulmonary and Respiratory Medicine ,Adult ,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010 ,in parallel with a similar increase in asthma-like symptoms and allergic rhinitis ,medicine.medical_specialty ,Rhinitis, Allergic, Perennial ,Population ,prevalence ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,031) ,Settore MED/01 - Statistica Medica ,symbols.namesake ,Young Adult ,Allergic rhiniti ,Humans ,Respiratory sounds ,Poisson regression ,education ,Respiratory Sounds ,Cross-Sectional Studie ,allergic rhinitis ,business.industry ,wheezing ,wheezing and allergic rhinitis increased from 4.1% to 6.6% ,Rhinitis, Allergic, Seasonal ,asthma ,in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993 ,medicine.disease ,873) ,Cross-Sectional Studies ,n=10 ,Relative risk ,Temporal trend ,Respiratory Sound ,n=6 ,n=18 ,business - Abstract
The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010; n=10,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis. Copyright©ERS 2012.
- Published
- 2012
5. Cost-Effectiveness Evaluation of a Care Bundle Intervention for Preventing Falls Among Italian Aged Inpatients in a Stepped-Wedge Cluster Randomized Controlled Trial
- Author
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Chamitava, L, primary, Di Gennaro, G, additional, Cazzoletti, L, additional, Mosci, D, additional, and Zanolin, ME, additional
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- 2017
- Full Text
- View/download PDF
6. Lung cancer: can staging improvement ensure a better survival?
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Gm, Stella, Cazzoletti L, and Alessandro Zanforlin
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Survival ,Lung Cancer - Abstract
Lung cancer is among the most common cancers in the world. Despite advances in defining the molecular mechanisms involved in lung oncogenesis and the remarkable efforts made to improve screening programs for secondary cancer prevention, patients' prognosis remains poor. Moreover, wide international inequalities remain apparent, even among developed countries. Here we analyze and discuss the findings of the extensive work by Walters S et al., recently published in "Thorax", which aimed to clarify whether differences in stage at diagnosis might explain these divergences. A better understanding of why survival differences between different states still exist will facilitate policy design to increase lung cancer overall survival itself and to bring it up to the highest international standards. It is the first international population-based study of lung cancer survival by stage at diagnosis and includes nearly 60,000 patients. By using a well detailed and appropriate statistical approach, authors conclude that improvement in outcomes is primarily related to a proper initial disease staging and that socioeconomic international and interregional inequalities might play a relevant role in this scenario. Our review takes in consideration both the methodological and scientific issues of the paper, focusing on the potential consequences in lung cancer management and on the need, in the post genomic era, of a molecular-based epidemiologic approach.
- Published
- 2013
7. The impact of climate and traffic-related NO2 on the prevalence of asthma and allergic rhinitis in Italy
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de Marco, R, Poli, A, Ferrari, M, Accordini, S, Giammanco, G, Bugiani, M, Villani, S, Ponzio, M, Bono, R, Carrozzi, L, Cavallini, R, Cazzoletti, L, Dallari, R, Ginesu, F, Lauriola, P, Mandrioli, P, Perfetti, L, Pignato, S, Pirina, P, STRUZZO, PIERLUIGI, de Marco, R, Poli, A, Ferrari, M, Accordini, S, Giammanco, G, Bugiani, M, Villani, S, Ponzio, M, Bono, R, Carrozzi, L, Cavallini, R, Cazzoletti, L, Dallari, R, Ginesu, F, Lauriola, P, Mandrioli, P, Perfetti, L, Pignato, S, Pirina, P, and Struzzo, Pierluigi
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Adult ,Rhinitis, Allergic, Perennial ,Ultraviolet Rays ,Climate ,Nitrogen Dioxide ,Asthma ,Cross-Sectional Studies ,Humans ,Italy ,Multivariate Analysis ,Prevalence ,Temperature ,Vehicle Emissions ,traffic-related pollution ,allergic rhinitis, asthma, climate, outdoor NO2 pollution, traffic-related pollution ,Allergic ,Multivariate Analysi ,climate ,Rhinitis ,Cross-Sectional Studie ,allergic rhinitis ,asthma ,Perennial ,Ultraviolet Ray ,outdoor NO2 pollution ,Human - Abstract
Environmental factors are likely to be involved in explaining the wide geographical variation in asthma and atopic diseases that has been documented in many recent epidemiological studies.
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- 2002
8. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010
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de Marco, R, Cappa, V, Accordini, S, Rava, M, Antonicelli, L, Bortolami, O, Braggion, M, Bugiani, M, Casali, L, Cazzoletti, L, Cerveri, I, Fois, Ag, Girardi, P, Locatelli, F, Marcon, A, Marinoni, A, Panico, Mg, Pirina, P, Villani, S, Zanolin, Me, Verlato, G, Montoli, E, Vesentini, R, Ferrari, M, Donatelli, L, Posenato, C, Cascio, V, Perbellini, L, Olivieri, M, D'Amato, J, Donatini, E, Martinelli, M, Pignatti, Pf, Bombieri, C, Bettin, Md, Trabetti, E, Poli, A, Nicolis, M, Sembeni, S, Bonifazi, F, Attena, F, Galdo, V, Bellia, V, Battaglia, S, Corsico, Ag, Albicini, F, Grosso, A, Ferretti, V, Miniucchi, A, Briziarelli, L, Marcarelli, M, Becciu, F, Deledda, A, Spada, V, Carosso, A, Piccioni, P, Castiglioni, G, Bono, R, Tassinari, R, Romanazzi, V, Rolla, G, Heffler, ENRICO MARCO, and Migliore, E.
- Published
- 2012
9. Gene Environment Interactions in Respiratory Diseases. Protocol, Standard Operative Procedures and Questionnaires
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de Marco, R, Verlato, G, Zanolin, Me, Accordini, S, Bortolami, O, Braggion, M, Cappa, V, Cazzoletti, L, Girardi, P, Locatelli, F, and Others
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Genes,Chronic obstructive pulmonary disease,Asthma ,Rhinitis,Case-control,Environment,Inflammatory biomarkers,Diet ,Genes ,Chronic obstructive pulmonary disease ,Inflammatory biomarkers ,Case-control ,Environment ,Asthma ,Rhinitis ,Diet ,Settore MED/01 - Statistica Medica - Published
- 2010
10. Gene Environment Interactions in Respiratory Diseases – Protocol, Standard Operative Procedures and Questionnaires
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The GEIRD Study Group: de Marco, R, Verlato, G, Zanolin, Me, Accordini, S, Bortolami, O, Braggion, M, Cappa, V, Cazzoletti, L, Girardi, P, Locatelli, F, Marcon, A, Nicolis, D, Rava, M, Vesentini, R, Ferrari, M, Donatelli, L, Posenato, C, Lo Cascio, V, Perbellini, L, Olivieri, M, D’Amato, J, Donatini, E, Martinelli, M, Pignatti, Pf, Bombieri, C, Bettin, Md, Trabetti, E, Poli, A, Nicolis, M, Sembeni, S, Antonicelli, L, Bonifazi, F, Attena, F, Galdo, V, Bellia, V, Battaglia, S, Cerveri, I, Corsico, Ag, Albicini, F, Grosso, A, Marinoni, A, Casali, L, Miniuc chi, A, Briziarelli, L, Marcarelli, M, Panico, Mg, Pirina, P, Fois, Ag, Becciu, F, Deledda, A, Spada, V, Bugiani, M, Carosso, A, Piccioni, P, Castiglioni, G, Bono, R, Tassinari, R, Romanazzi, V, Rolla, G, Heffler, ENRICO MARCO, and Migliore, E.
- Published
- 2010
11. The socio-economic burden of asthma is substantial in Europe
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Accordini, S, Corsico, A, Cerveri, I, Gislason, D, Gulsvik, A, Janson, C, Jarvis, D, Marcon, A, Pin, I, Vermeire, P, Almar, E, Bugiani, M, Cazzoletti, L, Duran-Tauleria, E, Jõgi, R, Marinoni, A, Martínez-Moratalla, J, Leynaert, B, de Marco, R, Therapy and Health Economics Working Group of the European Community Respiratory Health Survey II, Vesin, Aurélien, Department of Diagnostics and Public Health [Verona] (UNIVR | DDSP), Università degli studi di Verona = University of Verona (UNIVR), Division of Respiratory Diseases, Università degli Studi di Pavia = University of Pavia (UNIPV)-San Matteo Hospital, Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Department of Thoracic Medicine [Bergen], Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Department of Medical Sciences, Respiratory Medicine & Allergology, Uppsala University, Respiratory Epidemiology and Public Health Group, Imperial College London-National Heart and Lung Institute [UK], Groupe de Recherche Sur Le Cancer du Poumon : Bases Moléculaires de la Progression Tumorale, Dépistage et Thérapie Génique, Institut Albert Bonniot-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Campus Drie Eiken, University of Antwerp (UA), Unit of Epidemiology, Public Health Department of Castilla La Mancha, Unit of Pneumology, Consorzio Provinciale Antitubercolare, IMIM-Hospital del Mar, Generalitat de Catalunya, Foundation Tartu University Clinics, Lung Clinic, Department of Applied Health Sciences, Università degli Studi di Pavia = University of Pavia (UNIPV), Servicio de Neumología, Complejo Hospitalario Universitario de Albacete-Servicio de Salud de Castilla-La Mancha, Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Verona (UNIVR), University of Pavia-San Matteo Hospital, Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), and University of Pavia
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Adult ,Male ,MESH: Socioeconomic Factors ,MESH: Health Expenditures ,MESH: Asthma ,MESH: Probability ,MESH: Logistic Models ,ECRHS ,MESH: Risk Assessment ,Risk Assessment ,MESH: Multivariate Analysis ,MESH: Cross-Sectional Studies ,Cost of Illness ,Sickness Impact Profile ,Humans ,Probability ,MESH: Middle Aged ,MESH: Humans ,MESH: Health Services ,socio-economic burden, asthma, Europe, population-based study, ECRHS ,MESH: Quality of Life ,MESH: Adult ,Health Services ,Middle Aged ,MESH: Cost of Illness ,Asthma ,MESH: Male ,Europe ,Cross-Sectional Studies ,Logistic Models ,MESH: Sickness Impact Profile ,Socioeconomic Factors ,socio-economic burden ,population-based study ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Multivariate Analysis ,Quality of Life ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Europe ,Health Expenditures ,MESH: Female - Abstract
International audience; BACKGROUND: Few data are available on the asthma burden in the general population. We evaluated the level and the factors associated with the asthma burden in Europe. METHODS: In 1999-2002, 1152 adult asthmatics were identified in the European Community Respiratory Health Survey (ECRHS)-II and the socio-economic burden (reduced activity days and hospital services utilization in the past 12 months) was assessed. RESULTS: The asthmatics with a light burden (only a few reduced activity days) were 13.2% (95% CI: 11.4-15.3%), whereas those with a heavy burden (many reduced activity days and/or hospital services utilization) were 14.0% (95% CI: 12.1-16.1%). The burden was strongly associated with disease severity and a lower quality of life. Obese asthmatics had a significantly increased risk of a light [relative risk ratio (RRR) = 2.17; 95% CI: 1.18-4.00] or a heavy burden (RRR = 2.77; 95% CI: 1.52-5.05) compared with normal/underweight subjects. The asthmatics with frequent respiratory symptoms showed a threefold (RRR = 2.74; 95% CI: 1.63-4.61) and sixfold (RRR = 5.76; 95% CI: 3.25-10.20) increased risk of a light or a heavy burden compared with asymptomatic asthmatics, respectively. Moreover, the lower the forced expiratory volume in 1 s % predicted, the higher the risk of a heavy burden. The coexistence with chronic cough/phlegm only increased the risk of a heavy burden (RRR = 1.88; 95% CI: 1.16-3.06). An interaction was found between gender and IgE sensitization, with nonatopic asthmatic females showing the highest risk of a heavy burden (21.6%; 95% CI: 16.9-27.1%). CONCLUSIONS: The asthma burden is substantial in Europe. A heavy burden is more common in asthmatics with obesity, frequent respiratory symptoms, low lung function, chronic cough/phlegm and in nonatopic females.
- Published
- 2008
12. PMS46 - Cost-Effectiveness Evaluation of a Care Bundle Intervention for Preventing Falls Among Italian Aged Inpatients in a Stepped-Wedge Cluster Randomized Controlled Trial
- Author
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Chamitava, L, Di Gennaro, G, Cazzoletti, L, Mosci, D, and Zanolin, ME
- Published
- 2017
- Full Text
- View/download PDF
13. Il comfort dei pazienti sottoposti a chirurgia generale e vascolare
- Author
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Cunico, Laura, Cursio, N, and Cazzoletti, L.
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"Comfort" ,"nursing" ,"paziente chirurgico" - Published
- 2007
14. Studio descrittivo sul comfort dei pazienti sottoposti a colonscopia
- Author
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Cunico, Laura, Dal, Molin, and Cazzoletti, L.
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"comfort" ,"colonscopia" ,"nursing " - Published
- 2007
15. Chronic cough and phlegm in young adults
- Author
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Cerveri, I., Accordini, S., Corsico, A., Zoia, M. C., Carrozzi, L., Cazzoletti, L., Beccaria, M., Marinoni, A., Viegi, G., de Marco, R., Ginesu, F., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Dallari, R., Turrini, E., Foglia, M., Giammanco, G., Pignato, S., Rotondo, A., Cuspilici, A., Bugiani, M., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., Verlato, G., Zanolin, M. E., Locatelli, F., Battisti, L., Pattaro, C., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Chronic Obstructive ,Cross-sectional study ,Health surveys ,Population ,chronic obstructive pulmonary disease, cross-sectional studies, health surveys, risk factors, smoking ,Pulmonary Disease ,Pulmonary Disease, Chronic Obstructive ,Sex Factors ,Epidemiology ,medicine ,Prevalence ,Chronic obstructive pulmonary disease ,Cross-sectional studies ,Risk factors ,Smoking ,Asthma ,Chronic Disease ,Cough ,Cross-Sectional Studies ,Female ,Humans ,Italy ,Socioeconomic Factors ,Sputum ,Young adult ,education ,education.field_of_study ,business.industry ,Phlegm ,medicine.disease ,Obstructive lung disease ,respiratory tract diseases ,Chronic cough ,medicine.symptom ,business - Abstract
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underline that the presence of chronic cough and sputum production before airflow obstruction offers a unique opportunity to identify subjects at risk of chronic obstructive pulmonary disease for an early intervention. Current epidemiological data on these subjects are scant. Between 1998-2000, the authors evaluated the prevalence and characteristics of these symptoms by a multicentre cross-sectional survey of Italian people aged between 20-44 yrs from the general population (Italian Study on Asthma in Young Adults (ISAYA)). Besides the questions on asthma, more than 18,000 subjects answered the question: "Have you had cough and phlegm on most days for as much as 3 months per year and for at least two successive years?" The adjusted prevalence of subjects with chronic cough and phlegm was 11.9%, being 11.8% in males and 12.0% in females. From these subjects approximately 20% reported coexisting asthma and approximately 30%, predominately females, were nonsmokers. The survey showed that sex (female), smoking and low socioeconomic status were significantly and independently associated with chronic cough and phlegm, current smoking playing the major role. The prevalence of subjects with chronic cough and phlegm is startlingly high among young adults. Further follow-up studies are needed to establish how many of them will go on to develop chronic obstructive pulmonary disease.
- Published
- 2003
16. Is the prevalence of adult asthma and allergic rhinitis still increasing? Results of an Italian study
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Verlato, G, Corsico, A, Villani, S, Cerveri, I, Migliore, E, Accordini, S, Carolei, A, Piccioni, P, Bugiani, M, Lo Cascio, V, Marinoni, A, Poli, A, Ecrhs, de Marco R., Marinoni, ISAYA group Principal researchers: A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Alesina, R., Basso, O., Berrayah, L., Brusotti, R., Fanfulla, F., Moi, P., Frati, C., Karytinos, P., Bugiani, M., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, Paola, Bono, Roberto, Gigli, G., Giraudo, A., Brussino, Luisa, Bucca, Caterina, Rolla, Giovanni, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Sulotto, F., de Marco, R., Verlato, G., Accordini, S., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Campello, C., Rossi, F., Cannistrà, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Tardivo, S., Villani, A., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Allergy ,Rhinitis, Allergic, Perennial ,temporal trend ,Immunology ,Logistic regression ,asthma, allergic rhinitis, temporal trend, epidemiology ,Epidemiology ,Prevalence ,Immunology and Allergy ,Medicine ,Humans ,Non-response bias ,Young adult ,Asthma ,Response rate (survey) ,allergic rhinitis ,business.industry ,Rhinitis, Allergic, Seasonal ,Odds ratio ,asthma ,medicine.disease ,Italy ,Female ,epidemiology ,business - Abstract
The prevalence of asthma and allergic rhinitis has increased worldwide during the 1970s and 1980s.This study was aimed at evaluating whether the increasing trend in prevalence persisted during the 1990s in the young adult Italian population.In 1998 to 2000 a screening questionnaire was sent by mail to a general population sample aged 20 to 44 years; nonresponders were contacted again first by mail and then by phone, achieving a final response rate of 78.1% (6876 of 8800). Prevalence estimates, adjusted to correct for nonresponse bias, were compared with those recorded in Italy in 1991 to 1993 during the European Community Respiratory Health Survey, when response rate had been slightly higher (87.6%). Temporal variations in symptom prevalence were analyzed by a logistic regression model, controlling for sex, age, site of residence (urban vs suburban areas), season of response, response rate, and type of contact (mail vs phone).The prevalence of asthma attacks did not vary significantly from 1991 to 1993 (3.6%) to 1998 to 2000 (3.2%) (P =.188). The prevalence of asthma-like symptoms (wheezing, chest tightness, shortness of breath) tended to decrease in the age classes of 32.5 to 45 years, while increasing in the youngest age class (20 to 26 years). A clear-cut increase from 15.4% to 18.3% was observed for the prevalence of allergic rhinitis (P.001), whereas the proportion of people under antiasthmatic treatment increased in suburban areas but not in urban areas (interaction time-site of residence, P.001).Asthma prevalence has not increased during the last decade in Italy. The persistence of an increasing trend in allergic rhinitis prevalence deserves attention.
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- 2003
17. Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy
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De Marco, R., Locatelli, F., Cerveri, I., Bugiani, M., Marinoni, A., Giammanco, G., Accordini, S., Verlato, G., Zanolin, E., Buriani, O., Carrozzi, L., Dallari, R., Ginesu, F., Poli, A., Struzzo, P., Cavallini, R., Saletti, C., Cellini, M., Faustini, M., De Togni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, M., Pignato, S., Rotondo, A., Cuspilici, A., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., Zanolin, M. E., Cazzoletti, L., Battisti, L., Pattaro, C., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,National Health Programs ,Remission ,Cross-sectional study ,Immunology ,Population ,Remission, Spontaneous ,Rate ratio ,Asthma remission ,Asthma incidence ,Persistence of asthma ,Asthma ,Child ,Child, Preschool ,Cross-Sectional Studies ,Female ,Humans ,Incidence ,Infant ,Infant, Newborn ,Italy ,Retrospective Studies ,medicine ,Immunology and Allergy ,Young adult ,Preschool ,education ,education.field_of_study ,business.industry ,Spontaneous ,Incidence (epidemiology) ,Retrospective cohort study ,Newborn ,medicine.disease ,Natural history ,business - Abstract
The knowledge of the natural history of asthma from birth to adulthood could provide important clues for its cause and for the understanding of epidemiologic findings.This study is aimed at assessing the incidence and remission of asthma from birth to the age of 44 years by using data from 18,873 subjects involved in a large, nationally representative, cross-sectional study carried out in Italy from 1998 through 2000.The onset of asthma was defined as the age at the first attack, and remission was considered present when a subject was neither under treatment nor had experienced an asthma attack in the last 24 months. Person-years and survival techniques were used for the analysis.The average annual incidence rate for the 1953 to 2000 period was 2.56/1000 persons per year. Incidence peaked in boys less than 10 years of age (4.38/1000 persons per year) and in women 30 years of age or older (3.1/1000 persons per year) and showed a generational increase (incident rate ratio = 2.63 and 95% CI = 2.20-3.12 for 1974-1979 vs 1953-1958 birth cohort). The overall remission rate was 45.8% (41.6% in women and 49.5% in men, P.001). Asthmatic patients in remission had an earlier age at onset (7.8 vs 15.9 years, P.001) and a shorter duration of the disease (5.6 vs 16.1 years, P.001) than patients with current asthma. The probability of remission was strongly (P.001) and inversely related to the age at onset (62.8% and 15.0% in the10- andor =20-years age-at-onset groups, respectively).With respect to its natural history, asthma presents 2 different forms: early-onset asthma, which occurs early in childhood, affects mainly boys, and has a good prognosis, and late-onset asthma, which generally occurs during or after puberty, mainly affects women, and has a poor prognosis. The minority of patients with early-onset asthma who do not remit represents more than 35% of patients with current asthma in the general young adult population.
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- 2002
18. ADRB2 Gly16Arg polymorphism, asthma control and lung function decline
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Rebordosa, C, Kogevinas, M, Guerra, S, Castro-Giner, F, Jarvis, D, Cazzoletti, L, Pin, I, Siroux, V, Wjst, M, Antò, J M, de Marco, R, Estivill, X, Corsico, A G, Nielsen, R, Janson, Christer, Rebordosa, C, Kogevinas, M, Guerra, S, Castro-Giner, F, Jarvis, D, Cazzoletti, L, Pin, I, Siroux, V, Wjst, M, Antò, J M, de Marco, R, Estivill, X, Corsico, A G, Nielsen, R, and Janson, Christer
- Abstract
Arg/Arg homozygotes for the Gly16Arg polymorphism in the β(2)-adrenoreceptor gene (ADRB2) have a reduced response to short-acting β(2)-agonists but no effect has been associated with long-acting β(2)-agonists (LABAs). We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16Arg polymorphism, and to test whether LABA or inhaled corticosteroid (ICS) use modified these effects. There was an increased risk of noncontrolled asthma (OR 1.33, 95% CI 1.01-1.75; p=0.046) for each Arg allele. Among nonusers of ICS, the odds ratio of noncontrolled asthma among Arg/Arg versus Gly/Gly subjects was 2.73 (95% CI 1.28-5.82; p=0.009). No increased risk of noncontrolled asthma associated with the Arg allele was observed among ICS and/or LABA users. For each Arg allele, a mean±se decrease in decline in forced expiratory volume in 1 s of 7.7±2.5 mL·yr(-1) was found (p-value for trend 0.003), irrespective of ICS or LABA use. Arg/Arg subjects had an increased risk of bronchial hyperresponsiveness (BHR) versus Gly/Gly subjects, with an odds ratio of 2.51 (95% CI 1.12-5.63; p=0.025) if they did not use ICS. The Arg allele was associated with poorer asthma control, a steeper lung function decline and BHR. Absence of genotypic effects on asthma control among ICS users may be due to reversed β(2)-adrenoreceptor desensitisation.
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- 2011
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19. Quality-of-life and asthma-severity in general population asthmatics : results of the ECRHS II study
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Siroux, V., Boudier, A., Anto, J. M., Cazzoletti, L., Accordini, S., Alonso, J., Cerveri, I., Corsico, A., Gulsvik, A., Jarvis, D., de Marco, R., Marcon, A., Marques, E. A., Bugiani, M., Janson, Christer, Leynaert, B., Pin, I., Siroux, V., Boudier, A., Anto, J. M., Cazzoletti, L., Accordini, S., Alonso, J., Cerveri, I., Corsico, A., Gulsvik, A., Jarvis, D., de Marco, R., Marcon, A., Marques, E. A., Bugiani, M., Janson, Christer, Leynaert, B., and Pin, I.
- Abstract
BACKGROUND: Health-related quality-of-life (HRQL) has been poorly studied in large samples of asthmatics from the general population. HRQL and its relationship to asthma-severity were assessed among 900 asthmatics enrolled in the European Community Respiratory Health Survey. METHODS: Among asthmatics, 864 completed the short form-36 (SF-36) questionnaire and 477 also completed the Asthma Quality-of-life Questionnaire (AQLQ). A 4-class asthma-severity scale, combining clinical items, forced expiratory volume in 1 s and the level of treatment and the different asthma-severity components (each of the clinical items and hospitalization) were studied in relation to HRQL. RESULTS: Mean SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores (45.5 and 48.8 respectively) were lower than expected in a general population. The mean total AQLQ score was 5.8. The AQLQ score and to a lesser extent the PCS score were significantly related to the 4-class asthma-severity scale, although the risk of having a lower HRQL score did not vary proportionally across the levels of severity. Asthma-severity had no impact on the MCS score. Asthma attack frequency and hospitalization were associated with both total AQLQ and PCS scores, whereas nocturnal symptoms and lung function were more strongly related to the AQLQ and PCS score respectively. CONCLUSION: In population-based asthmatics, the specific AQLQ questionnaire, and also to a lesser extent the generic SF-36 questionnaire, were sensitive to asthma-severity. Frequencies of asthma attacks, of nocturnal symptoms and hospitalization for asthma have independent impact on HRQL.
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- 2008
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20. Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II
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Le Moual, N., primary, Carsin, A.-E., additional, Siroux, V., additional, Radon, K., additional, Norback, D., additional, Toren, K., additional, Olivieri, M., additional, Urrutia, I., additional, Cazzoletti, L., additional, Jacquemin, B., additional, Benke, G., additional, Kromhout, H., additional, Mirabelli, M. C., additional, Mehta, A. J., additional, Schlunssen, V., additional, Sigsgaard, T., additional, Blanc, P. D., additional, Kogevinas, M., additional, Anto, J. M., additional, and Zock, J.-P., additional
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- 2013
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21. Changes in the use of anti-asthmatic medication in an international cohort.
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Janson, Christer, de Marco, R, Accordini, S, Almar, E, Bugiani, M, Carolei, A, Cazzoletti, L, Cerveri, I, Corsico, A, Duran-Tauleria, E, Gislason, D, Gulsvik, Amund, Jögi, Rain, Marinoni, A, Martínez-Moratalla, J, Pin, I, Vermeire, P, Jarvis, D, Janson, Christer, de Marco, R, Accordini, S, Almar, E, Bugiani, M, Carolei, A, Cazzoletti, L, Cerveri, I, Corsico, A, Duran-Tauleria, E, Gislason, D, Gulsvik, Amund, Jögi, Rain, Marinoni, A, Martínez-Moratalla, J, Pin, I, Vermeire, P, and Jarvis, D
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- 2005
22. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010
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de Marco, R., primary, Cappa, V., additional, Accordini, S., additional, Rava, M., additional, Antonicelli, L., additional, Bortolami, O., additional, Braggion, M., additional, Bugiani, M., additional, Casali, L., additional, Cazzoletti, L., additional, Cerveri, I., additional, Fois, A.G., additional, Girardi, P., additional, Locatelli, F., additional, Marcon, A., additional, Marinoni, A., additional, Panico, M.G., additional, Pirina, P., additional, Villani, S., additional, Zanolin, M.E., additional, and Verlato, G., additional
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- 2011
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23. ADRB2 Gly16Arg polymorphism, asthma control and lung function decline
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Rebordosa, C., primary, Kogevinas, M., additional, Guerra, S., additional, Castro-Giner, F., additional, Jarvis, D., additional, Cazzoletti, L., additional, Pin, I., additional, Siroux, V., additional, Wjst, M., additional, Anto, J. M., additional, de Marco, R., additional, Estivill, X., additional, Corsico, A. G., additional, Nielsen, R., additional, and Janson, C., additional
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- 2011
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24. The control of asthma in Italy. The results og a multicentre Italian Study
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De Marco, R, Bugiani, M, Cazzoletti, L, Carosso, A, Accordini, S, Buriani, O, Carozzi, L, Dallari, R, Giammanco, G, Ginesu, F, Marioni, A, Lo Cascio, Poli, A, Struzzo, P, Janson, C, De Marco, R, Bugiani, M, Cazzoletti, L, Carosso, A, Accordini, S, Buriani, O, Carozzi, L, Dallari, R, Giammanco, G, Ginesu, F, Marioni, A, Lo Cascio, Poli, A, Struzzo, P, and Janson, C
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- 2003
25. Chronic cough and phlegm in young adults
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Cerveri, I., primary, Accordini, S., additional, Corsico, A., additional, Zoia, M.C., additional, Carrozzi, L., additional, Cazzoletti, L., additional, Beccaria, M., additional, Marinoni, A., additional, Viegi, G., additional, and de Marco, R., additional
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- 2003
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26. Long term predictors of asthma severity: a prospective population based longitudinal study
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Marco, R., Cazzoletti, L., and Cerveri, I.
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Epidemiology -- Research ,Asthma -- Prognosis ,Asthma -- Research ,Asthma -- Statistics ,Health ,Social sciences - Published
- 2004
27. Adequacy of asthma treatment to Gina recommendations: an international survey, ECRHS II
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Cazzoletti, L., Cerveri, I., and Corsico, A.
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Europe -- Research ,Asthma -- Research ,Asthma -- Statistics ,Health ,Social sciences - Published
- 2004
28. Asthmatics and ex-smokers respond early, heavy smokers respond late to mailed surveys in Italy
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Verlato, Giuseppe, Melotti, Roberto, Olivieri, Mario, Corsico, Angelo, Bugiani, Massimiliano, Accordini, Simone, Villani, Simona, Migliore, Enrica, Marinoni, Alessandra, Pirina, Pietro, Carrozzi, Laura, Bortolami, Oscar, Rava, Marta, de Marco, Roberto, Accordini, S., Verlato, G., Zanolin, E., Bugiani, M., Buriani, O., Carrozzi, L., Dallari, R., Giammanco, G., Ginesu, F., Marinoni, A., Poli, A., Struzzo, Pierluigi, Cavallini, R., Saletti, C., Cellini, M., Faustini, M., de Togni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, M., Pignato, S., Rotondo, A., Cuspilici, A., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., de Marco, R., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., Salomoni, A., Verlato, Giuseppe, Melotti, Roberto, Olivieri, Mario, Corsico, Angelo, Bugiani, Massimiliano, Accordini, Simone, Villani, Simona, Migliore, Enrica, Marinoni, Alessandra, Pirina, Pietro, Carrozzi, Laura, Bortolami, Oscar, Rava, Marta, de Marco, Roberto, Accordini, S., Verlato, G., Zanolin, E., Bugiani, M., Buriani, O., Carrozzi, L., Dallari, R., Giammanco, G., Ginesu, F., Marinoni, A., Poli, A., Struzzo, Pierluigi, Cavallini, R., Saletti, C., Cellini, M., Faustini, M., de Togni, A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Viegi, G., Pistelli, F., Di Pede, F., Paggiaro, P. L., Santolicandro, A., Giovannetti, P., Pirina, P., Ostera, S., Pinna, G. P., Farre, A., Imparato, S., Turrini, E., Foglia, M., Pignato, S., Rotondo, A., Cuspilici, A., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, R., Gigli, G., Giraudo, A., Brussino, M. C., Bucca, C., Rolla, G., Struzzo, P., Orefice, U., Schneider, M., Chittaro, F., Peresson, D., de Marco, R., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Ferrari, M., Biasin, C., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.
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Male ,Questionnaires ,Allergy ,asthmatics ,ex-smokers ,survey ,Allergic rhinitis ,Mail survey ,Epidemiology ,Prevalence ,Smoking habit ,Medicine ,Respiratory symptoms ,Young adult ,Response bias ,Medicine (all) ,Respiratory disease ,Phlegm ,Smoking ,Health Survey ,Middle Aged ,Chronic cough ,Italy ,Bias (Epidemiology) ,Female ,medicine.symptom ,Human ,Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Logistic Model ,Response bia ,Young Adult ,Allergic rhiniti ,Humans ,Smoking habits ,Asthma ,Questionnaire ,business.industry ,medicine.disease ,Health Surveys ,Surgery ,respiratory tract diseases ,Logistic Models ,Cough ,mail survey, response bias, respiratory symptoms, asthma, allergic rhinitis, smoking habits ,Respiratory symptom ,Patient Compliance ,business ,Demography - Abstract
Summary Rationale and objectives Response to mailed epidemiological surveys has decreased in recent decades. Since subjects with respiratory symptoms are usually early responders to surveys performed in Southern Europe, this trend could bias prevalence estimates. The present study aimed at evaluating the impact of non-response bias on prevalence estimates of respiratory symptoms and smoking habits. Methods In 9 centres, participating in the Italian Study on Asthma in Young Adults (ISAYA), random samples of people aged 20–45 years were administered a mailed questionnaire between 1998 and 2000. Non-responders were contacted again first by mail and then by phone. Cumulative response percentage was 30.5%, 52.4% and 72.7% (18,873/25,969), respectively, after the 1st, 2nd and 3rd contact. Results The prevalence of self-reported current asthma, asthma-like symptoms, and chronic cough/phlegm was more than halved from the first contact (5.6%, 17.8%, 14.6% respectively) to the third contact (2.7%, 6.4%, 6.9%). This pattern was less pronounced when considering allergic rhinitis and past asthma, whose prevalence decreased, respectively, from 21.5% to 15.6% and from 3.5% to 2.6%. At the same time the proportion of current smokers increased from 29.2% to 38%, while the proportion of ex-smokers decreased from 16.5% to 10.1%. In a multinomial logistic model current asthma, asthma-like symptoms, chronic cough/phlegm and smoking habits, and to a lower extent past asthma and allergic rhinitis, were significant predictors of late response. Conclusions In Italy when response percentage is low, the prevalence of current asthma, chronic cough/phlegm and ex-smokers is overestimated, while the proportion of current smokers is underestimated.
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29. Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
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Pietro Pirina, Pierpaolo Marchetti, Giulia Squillacioti, Elia Piccinno, Giuseppe Verlato, Salvatore Battaglia, Amelia Grosso, Alessandro Marcon, Giancarlo Pesce, Marcello Ferrari, Lucia Cazzoletti, Leonardo Antonicelli, Ferrari M., Piccinno E., Marcon A., Marchetti P., Cazzoletti L., Pirina P., Battaglia S., Grosso A., Squillacioti G., Antonicelli L., Verlato G., Pesce G., Bodescot, Myriam, Unit of Respiratory Medicine [Vérone, Italie], Department of Diagnostics and Public Health [Verona] (UNIVR | DDSP), Università degli studi di Verona = University of Verona (UNIVR)-Università degli studi di Verona = University of Verona (UNIVR), Unit of Epidemiology and Medical Statistics [Vérone, Italie], Department of Diagnostics and Public Health [Vérone, Italie], Unità Operativa di Pneumologia [Sassari, Italie], Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali [Sassari, Italie], Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS)-Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Dipartimento Universitario di Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' [Palerme, Italie] (PROMISE), Università degli studi di Palermo - University of Palermo, Division of Respiratory Diseases [Pavie, Italie], IRCCS 'San Matteo' Hospital Foundation [Pavie, Italie], Università degli Studi di Pavia = University of Pavia (UNIPV)-Università degli Studi di Pavia = University of Pavia (UNIPV), Department of Public Health and Pediatrics [Turin, Italie], Università degli studi di Torino = University of Turin (UNITO), Allergy Unit [Ancône, Italie], Department of Internal Medicine [Ancône, Italie], Azienda Ospedaliero-Universitaria Ospedali Riuniti [Ancône, Italie]-Azienda Ospedaliero-Universitaria Ospedali Riuniti [Ancône, Italie], Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), The GEIRD study was funded by the Cariverona foundation, the Italian Ministry of Health, Chiesi Farmaceutici SpA, and the Agenzia Italiana del Farmaco (AIFA)., University of Verona (UNIVR)-University of Verona (UNIVR), Università degli Studi di Sassari [Sassari] (UNISS)-Università degli Studi di Sassari [Sassari] (UNISS), University of Pavia-University of Pavia, University of Turin, Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Male ,LUNG-DISEASE ,Chronic bronchitis ,Pulmonology ,Epidemiology ,Blood Pressure ,Cardiovascular Medicine ,030204 cardiovascular system & hematology ,Vascular Medicine ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Cohort Studies ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Risk Factors ,Medicine and Health Sciences ,Odds Ratio ,chronic bronchiti ,Lung ,Rhinitis ,Aged, 80 and over ,education.field_of_study ,Alcohol Consumption ,Multidisciplinary ,Heart ,Middle Aged ,Cardiovascular disease ,CB ,Respiratory Function Tests ,3. Good health ,PREVALENCE ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Bronchitis, Chronic ,ALLERGIC RHINITIS ,INTERMITTENT CLAUDICATION ,Cardiovascular Diseases ,Hypertension ,Bronchitis ,Medicine ,chronic bronchitis ,Female ,Anatomy ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Science ,Population ,body mass index ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,DIAGNOSIS ,elderly ,chronic obstructive pulmonary disease ,Young Adult ,03 medical and health sciences ,Heart disorder ,BMI ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,Confidence Intervals ,medicine ,Humans ,COPD ,CORONARY-HEART-DISEASE ,education ,Nutrition ,Aged ,Asthma ,MYOCARDIAL-INFARCTION ,MUCUS HYPERSECRETION ,CIGARETTE-SMOKING ,ATHEROSCLEROSIS ,business.industry ,Biology and Life Sciences ,Odds ratio ,Rhinology ,asthma ,medicine.disease ,Intermittent claudication ,Diet ,Otorhinolaryngology ,030228 respiratory system ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Medical Risk Factors ,Case-Control Studies ,Relative risk ,Nasal Diseases ,Cardiovascular Anatomy ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,BMI, body mass index ,CB, chronic bronchitis ,COPD, chronic obstructive pulmonary disease - Abstract
Background and objectives Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population. Methods We used data collected in the Gene Environment Interactions in Respiratory Diseases study, an Italian multicentre, multicase-control study. Among 2463 participants (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, we identified 254 cases of CB without airflow obstruction, 418 cases of asthma without CB, 959 cases of rhinitis alone, and 832 controls. The associations of respiratory diseases with reported cardiovascular risk factors (lifestyles, hypertension, dyslipidaemia), heart disorders (myocardial infarction, coronary thrombosis, angina, aorta or heart surgery) and intermittent claudication were estimated through relative risk ratios (RRR) by multinomial logistic regression models. Results Compared to controls, CB cases were more likely to be heavy smokers, alcohol consumers, physically inactive, and to suffer from hypertension or dyslipidaemia; rhinitis cases were less obese but more likely to have hypertension. Asthma was significantly associated with current smoking. After adjusting for cardiovascular risk factors, heart disorders were associated with CB (RRR[95%CI]: 1.58[1.12–2.22]) and rhinitis (1.35[0.98–1.85]) and intermittent claudication was associated with CB (3.43[2.52–4.67]), asthma (1.51[1.04–2.21]) and rhinitis (2.03[1.34–3.07]). Conclusions CB, asthma and rhinitis were associated with cardiovascular risk factors and diseases. In particular, CB shared with cardiovascular diseases almost all risk factors and was strongly associated with a higher risk of heart disorders and intermittent claudication.
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- 2019
30. Socioeconomic inequalities in smoking habits are still increasing in Italy
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Giang Nguyen, Alessandro G. Fois, Pietro Pirina, Valeria Bellisario, Simona Villani, Francesco Attena, Roberto de Marco, Leonardo Antonicelli, Pierpaolo Marchetti, Pavilio Piccioni, Gabriele Nicolini, Lamberto Briziarelli, Angelo Corsico, Marcello Ferrari, MariaGrazia Panico, Simone Accordini, Lucio Casali, Lucia Cazzoletti, Roberto Bono, Giuseppe Verlato, Verlato, G, Accordini, S, Nguyen, G, Marchetti, P, Cazzoletti, L, Ferrari, M, Antonicelli, L, Attena, Francesco, Bellisario, V, Bono, R, Briziarelli, L, Casali, L, Corsico, Ag, Fois, A, Panico, M, Piccioni, P, Pirina, P, Villani, S, Nicolini, G, and de Marco, R.
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trends ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Cross-sectional study ,Public health ,medicine.medical_treatment ,Population ,Public Health, Environmental and Occupational Health ,smoking cessation ,socioeconomic status ,smoking initiation, smoking cessation, trends, socioeconomic status, Italy ,Italy ,Environmental health ,smoking initiation ,Epidemiology ,Medicine ,Smoking cessation ,Biostatistics ,Young adult ,business ,education ,Socioeconomic status ,Research Article - Abstract
Background: Socioeconomic inequalities in smoking habits have stabilized in many Western countries. This study aimed at evaluating whether socioeconomic disparities in smoking habits are still enlarging in Italy and at comparing the impact of education and occupation. Methods: In the frame of the GEIRD study (Gene Environment Interactions in Respiratory Diseases) 10,494 subjects, randomly selected from the general population aged 20–44 years in seven Italian centres, answered a screening questionnaire between 2007 and 2010 (response percentage = 57.2%). In four centres a repeated cross-sectional survey was performed: smoking prevalence recorded in GEIRD was compared with prevalence recorded between 1998 and 2000 in the Italian Study of Asthma in Young Adults (ISAYA). Results: Current smoking was twice as prevalent in people with a primary/secondary school certificate (40-43%) compared with people with an academic degree (20%), and among unemployed and workmen (39%) compared with managers and clerks (20-22%). In multivariable analysis smoking habits were more affected by education level than by occupation. From the first to the second survey the prevalence of ever smokers markedly decreased among housewives, managers, businessmen and free-lancers, while ever smoking became even more common among unemployed (time-occupation interaction: p = 0.047). At variance, the increasing trend in smoking cessation was not modified by occupation. Conclusion: Smoking prevalence has declined in Italy during the last decade among the higher socioeconomic classes, but not among the lower. This enlarging socioeconomic inequality mainly reflects a different trend in smoking initiation.
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- 2014
31. Non-lesional white matter in relapsing-remitting multiple sclerosis assessed by multicomponent T2 relaxation.
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Bontempi P, Rozzanigo U, Marangoni S, Fogazzi E, Ravanelli D, Cazzoletti L, Giometto B, and Farace P
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- Humans, Infant, Magnetic Resonance Imaging methods, Water, Brain pathology, Multiple Sclerosis, Relapsing-Remitting diagnostic imaging, Multiple Sclerosis, Relapsing-Remitting pathology, White Matter diagnostic imaging, White Matter pathology, Multiple Sclerosis pathology
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Introduction: The purpose of the study is to investigate, by T2 relaxation, non-lesional white matter (WM) in relapsing-remitting (RR) multiple sclerosis (MS)., Methods: Twenty stable RR MS patients underwent 1.5T Magnetic Resonance Imaging (MRI) with 3D Fluid-Attenuated Inversion-Recovery (FLAIR), 3D-T1-weighted, and T2-relaxation multi-echo sequences. The Lesion Segmentation Tool processed FLAIR images to identify focal lesions (FLs), whereas T1 images were segmented to identify WM and FL sub-volumes with T1 hypo-intensity. Non-lesional WM was obtained as the segmented WM, excluding FL volumes. The multi-echo sequence allowed decomposition into myelin water, intra-extracellular water, and free water (Fw), which were evaluated on the segmented non-lesional WM. Correlation analysis was performed between the non-lesional WM relaxation parameters and Expanded Disability Status Scale (EDSS), disease duration, patient age, and T1 hypo-intense FL volumes., Results: The T1 hypo-intense FL volumes correlated with EDSS. On the non-lesional WM, the median Fw correlated with EDSS, disease duration, age, and T1 hypo-intense FL volumes. Bivariate EDSS correlation of FL volumes and WM T2-relaxation parameters did not improve significance., Conclusion: T2 relaxation allowed identifying subtle WM alterations, which significantly correlated with EDSS, disease duration, and age but do not seem to be EDSS-predictors independent from FL sub-volumes in stable RR patients. Particularly, the increase in the Fw component is suggestive of an uninvestigated prodromal phenomenon in brain degeneration., (© 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
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- 2023
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32. Burden and risk factors of chronic obstructive pulmonary disease in Sub-Saharan African countries, 1990-2019: a systematic analysis for the Global Burden of disease study 2019.
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Alemayohu MA, Zanolin ME, Cazzoletti L, Nyasulu P, and Garcia-Larsen V
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Background: Sub-Saharan Africa (SSA) has experienced a surge of non-communicable diseases (NCDs) including chronic obstructive pulmonary disease (COPD) over the past two decades. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), in this study we have estimated the burden and attributable risk factors of COPD across SSA countries between 1990 and 2019., Methods: COPD burden and its attributable risk factors were estimated using data from the 2019 GBD. Percentage change was estimated to show the trend of COPD estimates from 1990 to 2019. COPD estimates attributable by risk factors were also reported to ascertain the risk factor that brings the greatest burden by sex and locations (at country and regions level)., Findings: In 2019, all-age prevalent cases of COPD in SSA were estimated to be 10.3 million (95% Uncertainty Intervals (UI) 9.7 million to 10.9 million) showing an increase of 117% compared with the number of all-age COPD cases in 1990. From 1990 to 2019, SSA underwent an increased percentage change in all-age YLDs due to COPD ranging from 41% in Lesotho to 203% in Equatorial Guinea. The largest premature mortality due to COPD was reported from Central SSA accounting for 729 subjects (95% UI, 509-1078). The highest rate of DALYs attributable to COPD was observed in Lesotho. Household air pollution from solid fuel was the primary contributor of the age standardized YLDs, death rate, and DALYs rate per 100,000 population., Interpretation: The prevalence of COPD in SSA has had a steady increase over the past three decades and has progressively become a major public health burden across the region. Household air pollution from solid fuel is the primary contributor to COPD related burden, and its percentage contribution showed a similar trend to the reduction of COPD attributed age-standardized DALY rate. The methodological limitations of surveys and datapoints included in the GBD need to be considered when interpreting these associations., Funding: There are no specific fundings received for this study. The Global Burden of Disease study was supported by funding from the Bill & Melinda Gates Foundation., Competing Interests: All authors in the writing team declare no competing interests., (© 2023 The Authors.)
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- 2023
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33. Patient Safety Subcultures among Nursing Home Staff in Italy: A Cross-Sectional Study.
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Tocco Tussardi I, Cazzoletti L, Zanolin ME, Comini A, Visentin D, Torri E, Tardivo S, and Moretti F
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Nursing home (NH) residents are vulnerable subjects and highly susceptible to adverse events. Knowledge of patient safety culture (PSC) is essential for an organization to ensure patient safety. However, research on PSC in NHs, and its variability among staff, is still scarce. This study aimed to explore whether and how PSC differed among NH staff (Managers, Nurses, Direct Care Staff, Support Staff, Administrative Staff and Other Providers) in the Autonomous Province of Trento, Italy. This study employed a cross-sectional design and collected data from 1145 NH providers using the Nursing Home Survey on Patient Safety Culture (NHSPSC). Data were analyzed using linear mixed models, with each of the 12 NHSPSC domains as a response variable. The majority of the respondents (61.6%) were Direct Care Staff members. 'Feedback and Communication about Incidents' and 'Overall Perceptions of Resident Safety' were the domains with the highest proportions of positive answers (PPAs). For most staff categories, 'Staffing' was the domain with the lowest PPA. Support Staff showed significantly lower scores in the majority of domains (8/12). Shorter job tenure, fewer weekly working hours, working mostly during the day and working in highly specialized areas were associated with higher scores in several domains. Interventions to improve PSC must consider the differences between professional groups. Further research is needed to explore the relationship between job-related features and perceptions of patient safety among NH workers.
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- 2023
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34. Circulating eosinophil levels and lung function decline in stable chronic obstructive pulmonary disease: a retrospective longitudinal study.
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Ferrari M, Pizzini M, Cazzoletti L, Ermon V, Spelta F, De Marchi S, Carbonare LGD, and Crisafulli E
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- Humans, Retrospective Studies, Longitudinal Studies, Lung, Pulmonary Disease, Chronic Obstructive
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Objective: Whether blood eosinophils (bEOS) in chronic obstructive pulmonary disease (COPD) are associated with disease progression is a topic of debate. We aimed to evaluate whether the differential white blood cell (WBC) count, symptoms and treatment may predict lung function decline and exacerbations in COPD patients., Methods: We retrospectively examined stable COPD patients with a minimum follow-up of 3 years at our outpatients' clinic. We collected information about lung volumes (FEV1, FVC), the total and differential WBC count, acute exacerbations of COPD (number in the 12 months before the beginning of the study=AE-COPD-B, and during the follow-up=AE-COPD-F), smoking status and treatment. FEV1 decline and AE-COPD-F were described by using a generalized linear model and a 2-level random intercept negative binomial regression, respectively. The models included eosinophil and neutrophil counts as potential predictors and were adjusted by sex, age, smoking status, AE-COPD-B, treatment with bronchodilators and inhaled corticosteroids (ICS)., Results: Sixty-eight patients were considered, 36 bEOS- (<170 cells/μL, the median value) and 32 bEOS+ (≥170 cells/μL). ∆FEV1 was higher in bEOS+ than bEOS- (34.86 mL/yr vs 4.49 mL/yr, p=0.029). After adjusting for potential confounders, the eosinophil count was positively (β=19.4; CI 95% 2.8, 36.1; p=0.022) and ICS negatively (β=-57.7; CI 95% -91.5,-23.9; p=0.001) associated with lung function decline. bEOS were not found to be associated with the number of AE-COPD-F., Conclusion: In stable COPD patients, a higher level of blood eosinophils (albeit in the normal range) predicts a greater FEV1 decline, while ICS are associated with a slower progression of airflow obstruction.
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- 2022
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35. Six-minute walk distance in healthy subjects: reference standards from a general population sample.
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Cazzoletti L, Zanolin ME, Dorelli G, Ferrari P, Dalle Carbonare LG, Crisafulli E, Alemayohu MA, Olivieri M, Verlato G, and Ferrari M
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- Adult, Aged, Child, Child, Preschool, Exercise Test, Female, Healthy Volunteers, Humans, Infant, Male, Middle Aged, Reference Standards, Reference Values, Body Height, Walking
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Introduction: The 6-min walking distance (6MWD) test is a useful tool to obtain a measure of functional exercise capacity. However, reference equations have been mainly based on selected populations or small samples. The purpose of this study was to determine the reference equations to predict the 6MWD in a large Italian population sample of healthy adults of a wide age range., Methods: In the frame of the multi case-control population-based study Gene Environment Interaction in Respiratory Diseases (GEIRD), we studied 530 healthy subjects: 287 females ranging 21-76 and 243 males ranging 21-78 years of age. We measured 6MWD, demographic and anthropometric data and collected the reported physical activity. A multiple linear regression model for the 6MWD included age, age
2 , height, weight and physical activity for both sex equations. The two-way interaction age-height and age-weight and the quadratic terms of weight and height were also tested for inclusion separately in each model., Results: The mean ± SD for 6MWD was 581.4 ± 66.5 m (range 383-800 m) for females and 608.7 ± 80.1 m (range 410-875 m) for males. The reference equations were 6MWD = 8.10*age + 1.61*heightcm -0.99*weightkg + 22.58*active-0.10*age2 + 222.55 for females (R squared = 0.238) and 6MWD = 26.80*age + 8.46*heightcm -0.45*weightkg -2.54*active-0.06*age2 -0.13*age*heightcm -890.18 for males (R squared = 0.159), where "active" is 1 when the subject is physically active, 0 otherwise., Conclusion: This study is the first to describe the 6MWD in a large population sample of young, middle aged and elderly healthy Caucasian subjects, and to determine reference equations. These findings will help to improve the evaluation of Italian and European patients with diseases influencing their functional capacity., (© 2022. The Author(s).)- Published
- 2022
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36. Correction: Cazzoletti et al. Risk Factors Associated with Nursing Home COVID-19 Outbreaks: A Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2021, 18 , 8434.
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Cazzoletti L, Zanolin ME, Tocco Tussardi I, Alemayohu MA, Zanetel E, Visentin D, Fabbri L, Giordani M, Ruscitti G, Benetollo PP, Tardivo S, and Torri E
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The authors would like to make the following corrections to this paper [...].
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- 2021
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37. Risk Factors Associated with Nursing Home COVID-19 Outbreaks: A Retrospective Cohort Study.
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Cazzoletti L, Zanolin ME, Tocco Tussardi I, Alemayohu MA, Zanetel E, Visentin D, Fabbri L, Giordani M, Ruscitti G, Benetollo PP, Tardivo S, and Torri E
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- Disease Outbreaks, Humans, Nursing Homes, Retrospective Studies, Risk Factors, SARS-CoV-2, COVID-19
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Background: The coronavirus disease 2019 (COVID-19) pandemic had a devastating impact on nursing homes/long-term care facilities. This study examined the relationship between geography, size, design, organizational characteristics, and implementation of infection prevention and control (IPC) measures and the extent of COVID-19 outbreaks in nursing homes in the Autonomous Province of Trento (Italy) during the time frame of March-May 2020., Methods: The analysis included 57 nursing homes (5145 beds). The association between median cumulative incidence of COVID-19 cases among residents and characteristics of nursing homes was assessed by Mann-Whitney U test, Kruskal-Wallis test or Spearman rho. To evaluate the potential confounding of geographical area, a 2-level random intercept logistic model was fitted, with level 1 units (patients in nursing homes) nested into level 2 units (nursing homes), and "being a COVID-19 case" as the dependent variable., Results: Median cumulative incidence was not significantly associated with any of the variables, except for geographical region ( p = 0.002). COVID-19 cases clustered in the part of the province bordering the Italian region most affected by the pandemic (Lombardy) (45.2% median cumulative incidence)., Conclusions: Structural/organizational factors and standard IPC measures may not predict the epidemiology of COVID-19 outbreaks and be sufficient alone to protect nursing homes against them.
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- 2021
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38. Comparison between MRI and Arthroscopy of the Wrist for the Assessment of Posttraumatic Lesions of Intrinsic Ligaments and the Triangular Fibrocartilage Complex.
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De Santis S, Cozzolino R, Luchetti R, and Cazzoletti L
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Background Magnetic resonance imaging (MRI) has been considered the most appropriate examination for wrist ligament injuries diagnosis, but it frequently fails to assess the intrinsic ligament lesion. Therefore, wrist arthroscopy is required to enhance and define the diagnosis. Purpose We compare the MRI imaging with wrist arthroscopy for intrinsic wrist ligaments (scapholunate [SL] and lunotriquetral [LT]) and triangular fibrocartilage complex (TFCC) injuries detection. Patients and Methods From 2007 to 2014, 532 patients affected by suspected SL, LT, and TFCC posttraumatic ligament injury have been investigated by 1.5-Tesla MRI and wrist arthroscopy. Inclusion and exclusion criteria were adopted. Only for SL ligament injury, the arthroscopic findings of complete (stage IV) and partial (stages I-III) SL ligament injury were compared with MRI findings. Statistical analysis, including sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, and the diagnostic odds ratio, was used to compare MRI with arthroscopic findings. Results A total of 146 patients were accepted in the study. In 68 cases of arthroscopic SL ligament lesion, MRI confirmed the diagnosis only in 50% of the cases. In partial SL lesions, MRI was positive in 24.3% and in complete SL lesions, MRI was positive in 80.6% of the cases. In 10 cases of arthroscopic LT ligament lesion, MRI was positive in 30.0% of the cases. In 33 patients with arthroscopic TFCC lesion, MRI was positive in 66.7% of the cases. Conclusion 1.5-T MRI demonstrated to fail in confirming the lesion of SL, LP, and TFCC ligaments respectively in 50, 70, and 33.3% of the cases positive at arthroscopy. In complete SL ligament lesion, MRI reaches a higher sensitivity than in partial lesion. Arthroscopy remains the best method to demonstrate the ligament lesion and obtain more information regarding the extent and quality of the ligament damage. Level of Evidence This is a Level II, retrospective comparative study., Competing Interests: Conflict of Interest None declared., (Thieme. All rights reserved.)
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- 2021
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39. Postural Control in Childhood: Investigating the Neurodevelopmental Gradient Hypothesis.
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Zoccante L, Ciceri ML, Chamitava L, Di Gennaro G, Cazzoletti L, Zanolin ME, Darra F, and Colizzi M
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- Adolescent, Case-Control Studies, Child, Child, Preschool, Humans, Postural Balance, Attention Deficit Disorder with Hyperactivity epidemiology, Autism Spectrum Disorder epidemiology, Tourette Syndrome
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Neurodevelopmental disorders (NDDs) have been suggested to lie on a gradient continuum, all resulting from common brain disturbances, but with different degrees of impairment severity. This case-control study aimed to assess postural stability against such hypothesis in 104 children/adolescents aged 5-17, of whom 81 had NDDs and 23 were healthy controls. Compared to healthy controls, Autism Spectrum Disorder (ASD) resulted in the most severely impaired neurodevelopmental condition, followed by Attention Deficit Hyperactive Disorder (ADHD) and Tourette Syndrome (TS). In particular, while ASD children/adolescents performed worse than healthy controls in a number of sensory conditions across all parameters, ADHD children/adolescents performed worse than healthy controls only in the sway area for the most complex sensory conditions, when their vision and somatosensory functions were both compromised, and performance in Tourette Syndrome (TS) was roughly indistinguishable from that of healthy controls. Finally, differences were also observed between clinical groups, with ASD children/adolescents, and to a much lesser extent ADHD children/adolescents, performing worse than TS children/adolescents, especially when sensory systems were not operationally accurate. Evidence from this study indicates that poor postural control may be a useful biomarker for risk assessment during neurodevelopment, in line with predictions from the gradient hypothesis.
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- 2021
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40. Dietary flavonoids and respiratory diseases: a population-based multi-case-control study in Italian adults.
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Mattioli V, Zanolin ME, Cazzoletti L, Bono R, Cerveri I, Ferrari M, Pirina P, and Garcia-Larsen V
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- Adult, Anthocyanins, Case-Control Studies, Humans, Italy epidemiology, Prospective Studies, Risk Factors, Diet, Flavonoids administration & dosage, Respiratory Tract Diseases epidemiology
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Objective: To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins)., Design: Multi-case-control study., Setting: The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, education, total energy intake, vitamin C intake and total fruit intake were used to examine the associations between dietary exposures and the relative risk ratio (RRR) of being a case., Participants: Individuals (n 990) hierarchically defined as follows: cases with asthma (current, n 159; past, n 78), chronic bronchitis (n 47), rhinitis (allergic rhinitis, n 167; non-allergic rhinitis, n 142) and controls (n 97)., Results: An increase of 1 sd in flavanones was associated with a reduced risk of non-allergic rhinitis (adjusted RRR = 0·68, 95 % CI 0·47, 0·97); a similar result was found comparing the highest v. lowest quartile of flavanones intake (adjusted RRR = 0·24, 95 % CI 0·10, 0·59)., Conclusions: Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-allergic rhinitis. No associations were found between other flavonoids and the considered outcomes.
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- 2020
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41. Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases.
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Chamitava L, Cazzoletti L, Ferrari M, Garcia-Larsen V, Jalil A, Degan P, Fois AG, Zinellu E, Fois SS, Fratta Pasini AM, Nicolis M, Olivieri M, Corsico A, Bono R, Pirina P, and Zanolin ME
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- Adult, Aged, Case-Control Studies, Dinoprost blood, Female, Humans, Leukocyte Count, Male, Middle Aged, Oxidative Stress, Young Adult, 8-Hydroxy-2'-Deoxyguanosine blood, Asthma blood, Biomarkers blood, Bronchitis, Chronic blood, Dinoprost analogs & derivatives, Glutathione blood
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Introduction: The global burden of chronic airway diseases represents an important public health concern. The role of oxidative stress and inflammation in the pathogenesis of these diseases is well known. The aim of this study is to evaluate the behavior of both inflammatory and oxidative stress biomarkers in patients with chronic bronchitis, current asthma and past asthma in the frame of a population-based study., Methods: For this purpose, data collected from the Gene Environment Interactions in Respiratory Diseases (GEIRD) Study, an Italian multicentre, multicase-control study, was evaluated. Cases and controls were identified through a two-stage screening process of individuals aged 20-65 years from the general population. Out of 16,569 subjects selected from the general population in the first stage of the survey, 2259 participated in the clinical evaluation. Oxidative stress biomarkers such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), 8-isoprostane and glutathione and inflammatory biomarkers such as Fractional Exhaled Nitric Oxide (FENO) and white blood cells were evaluated in 1878 subjects., Results: Current asthmatics presented higher levels of FENO (23.05 ppm), leucocytes (6770 n/µL), basophils (30.75 n/µL) and eosinophils (177.80 n/µL), while subjects with chronic bronchitis showed higher levels of GSH (0.29 mg/mL) and lymphocytes (2101.6 n/µL). The multivariable multinomial logistic regression confirmed high levels of leucocytes (RRR = 1.33), basophils (RRR = 1.48), eosinophils (RRR = 2.39), lymphocytes (RRR = 1.26) and FENO (RRR = 1.42) in subjects with current asthma. Subjects with past asthma had a statistically significant higher level of eosinophils (RRR = 1.78) with respect to controls. Subjects with chronic bronchitis were characterized by increased levels of eosinophils (RRR = 2.15), lymphocytes (RRR = 1.58), GSH (RRR = 2.23) and 8-isoprostane (RRR = 1.23)., Conclusion: In our study, current asthmatics show a greater expression of the inflammatory profile compared to subjects who have had asthma in the past and chronic bronchitis. On the other hand, chronic bronchitis subjects showed a higher rate of expression of oxidative stress biomarkers compared to asthmatic subjects. In particular, inflammatory markers such as circulating inflammatory cells and FENO seem to be more specific for current asthma, while oxidative stress biomarkers such as glutathione and 8-isoprostane appear to be more specific and applicable to patients with chronic bronchitis.
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- 2020
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42. Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases.
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Ferrari M, Piccinno E, Marcon A, Marchetti P, Cazzoletti L, Pirina P, Battaglia S, Grosso A, Squillacioti G, Antonicelli L, Verlato G, and Pesce G
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- Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Confidence Intervals, Female, Humans, Intermittent Claudication complications, Lung physiopathology, Male, Middle Aged, Odds Ratio, Respiratory Function Tests, Risk Factors, Young Adult, Asthma complications, Bronchitis, Chronic complications, Cardiovascular Diseases complications, Cardiovascular Diseases epidemiology, Pulmonary Disease, Chronic Obstructive complications, Rhinitis complications
- Abstract
Background and Objectives: Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population., Methods: We used data collected in the Gene Environment Interactions in Respiratory Diseases study, an Italian multicentre, multicase-control study. Among 2463 participants (age 21-86, female 50%) who underwent standardized interviews, skin prick and lung function tests, we identified 254 cases of CB without airflow obstruction, 418 cases of asthma without CB, 959 cases of rhinitis alone, and 832 controls. The associations of respiratory diseases with reported cardiovascular risk factors (lifestyles, hypertension, dyslipidaemia), heart disorders (myocardial infarction, coronary thrombosis, angina, aorta or heart surgery) and intermittent claudication were estimated through relative risk ratios (RRR) by multinomial logistic regression models., Results: Compared to controls, CB cases were more likely to be heavy smokers, alcohol consumers, physically inactive, and to suffer from hypertension or dyslipidaemia; rhinitis cases were less obese but more likely to have hypertension. Asthma was significantly associated with current smoking. After adjusting for cardiovascular risk factors, heart disorders were associated with CB (RRR[95%CI]: 1.58[1.12-2.22]) and rhinitis (1.35[0.98-1.85]) and intermittent claudication was associated with CB (3.43[2.52-4.67]), asthma (1.51[1.04-2.21]) and rhinitis (2.03[1.34-3.07])., Conclusions: CB, asthma and rhinitis were associated with cardiovascular risk factors and diseases. In particular, CB shared with cardiovascular diseases almost all risk factors and was strongly associated with a higher risk of heart disorders and intermittent claudication., Competing Interests: The authors have declared that no competing interests exist.
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- 2019
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43. Vegetable but not animal protein intake is associated to a better physical performance: a study on a general population sample of adults.
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Gazzani D, Zamboni F, Spelta F, Ferrari P, Mattioli V, Cazzoletti L, Zanolin E, Tardivo S, and Ferrari M
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Background: The research was conducted in the frame of a population-based, case control study, called Genes Environment Interaction in Respiratory Disease., Objective: To assess the association between protein intake and physical performance in a general population sample., Design: Researchers investigated the association between the participants' dietary information and their physical performance using the 6-min walking test and the distance walked in metres (6MWD) as main outcome measure. Information on dietary intake was collected using the validated European Investigation into Cancer and Nutrition food frequency questionnaires (FFQs). Then, daily intake of energy and macronutrients was estimated by means of the NAF software (nutritional analysis of FFQ). Linear regression models were used to evaluate the associations between vegetable, animal and total protein intakes and the 6MWD. The models were adjusted for socio-demographic features, total fats and available carbohydrate intakes., Results: The participants were 223 subjects (57% females) aged between 23 and 68 years. Their mean vegetable and animal proteins intake for gram/kg of body weight/day were, respectively, 0.4 and 0.7. After adjusting for all the potential confounders, there was a significant increase of 20.0 (95% CI 0.8; 39.2) m in the distance walked for an increase in 10 g/day of vegetable proteins and non-significant variations of -1.8 (95% CI -9.3; 5.7) m for an increase in 10 g/day of animal proteins and of 0.5 (95% CI -6.8; 7.7) for an increase in 10 g/day of total proteins., Discussion and Conclusions: Our result suggests a positive role of vegetable proteins on physical performance. Whether this result is related to the high protein intake itself or may be a consequence of the other properties of plant-based foods deserves further investigation., Competing Interests: The authors declare no potential conflicts of interest., (© 2019 Diana Gazzani et al.)
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- 2019
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44. Health-related quality of life varies in different respiratory disorders: a multi-case control population based study.
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Cappa V, Marcon A, Di Gennaro G, Chamitava L, Cazzoletti L, Bombieri C, Nicolis M, Perbellini L, Sembeni S, de Marco R, Spelta F, Ferrari M, and Zanolin ME
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- Adult, Asthma psychology, Case-Control Studies, Female, Humans, Hypersensitivity psychology, Italy epidemiology, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive psychology, Severity of Illness Index, Surveys and Questionnaires, Asthma epidemiology, Hypersensitivity epidemiology, Pulmonary Disease, Chronic Obstructive epidemiology, Quality of Life
- Abstract
Background and Objective: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB)., Methods: Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. The relationships between HRQL (in terms of Physical (PCS) and Mental Component Scores (MCS)), respiratory diseases, and covariates were evaluated., Results: With respect to controls, the adjusted PCS median score was worse in subjects suffering from current asthma (- 1.7; 95%CI:-2.8;-0.6), CB (- 3.8; 95%CI:-5.7;-1.9), and COPD (- 5.6; 95%CI:-8.1;-3.1). MCS was worse in current asthmatics (- 2.2; 95%CI:-4.1;-0.3), CB (- 5.5; 95%CI:-8.7;-2.2), and COPD cases (- 4.6; 95%CI:-8.8;-0.5) as well., Conclusions: To our knowledge, this is the first study in the general population that analyzed HRQL performing a simultaneous comparison of HRLQ in several respiratory disorders. We found that subjects suffering from COPD, CA, and CB had the poorest HRQL. Clinicians should carefully consider the possible impact of respiratory disorders as CB and not only that of CA and COPD.
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- 2019
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45. Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III.
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Janson C, Accordini S, Cazzoletti L, Cerveri I, Chanoine S, Corsico A, Ferreira DS, Garcia-Aymerich J, Gislason D, Nielsen R, Johannessen A, Jogi R, Malinovschi A, Martinez-Moratalla Rovira J, Marcon A, Pin I, Quint J, Siroux V, Almar E, Bellisario V, Franklin KA, Gullón JA, Holm M, Heinrich J, Nowak D, Sánchez-Ramos JL, Weyler JJ, and Jarvis D
- Abstract
Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly selected subjects, while changes in adults with persistent asthma were analysed in 369 participants. The study compares data from three surveys in 24 centres in 11 countries. The use of ICSs increased from 1.7% to 5.9% in the general population and the regular use of ICSs increased from 19% to 34% among persistent asthmatic subjects. The proportion of asthmatic subjects reporting asthma attacks in the last 12 months decreased, while the proportion that had seen a doctor in the last 12 months remained unchanged (42%). Subjects with asthma who had experienced attacks or had seen a doctor were more likely to use ICSs on a regular basis. Although ICS use has increased, only one-third of subjects with persistent asthma take ICSs on a regular basis. Less than half had seen a doctor during the last year. This indicates that underuse of ICSs and lack of regular healthcare contacts remains a problem in the management of asthma., Competing Interests: Conflict of interest: J.A. Gullón has nothing to disclose. Conflict of interest: R. Jogi reports receiving Estonian Research Council Personal Research Grant 562 during the conduct of the study; consultancy and lecture fees from GSK, Boehringer and Novartis, and travel, accommodation and meeting expenses from GSK and Boehringer. Conflict of interest: A. Johannessen has nothing to disclose. Conflict of interest: V. Bellisario has nothing to disclose. Conflict of interest: C. Janson reports receiving personal fees for lectures and advisory boards from AstraZeneca, Boehringer Ingelheim, Chiesi, Novartis and Teva, and for advisory boards from GSK, outside the submitted work. Conflict of interest: D. Jarvis reports receiving grants from Medical Research Council, during the conduct of the study. Conflict of interest: D. Gislason has nothing to disclose. Conflict of interest: I. Pin reports receiving travel grants from MSD, presentation fees from Teva, and both from AstraZeneca, outside the submitted work. Conflict of interest: J.L. Sánchez-Ramos has nothing to disclose. Conflict of interest: Isa Cerveri has nothing to disclose. Conflict of interest: S. Accordini has nothing to disclose. Conflict of interest: J.J. Weyler has nothing to disclose. Conflict of interest: R. Nielsen reports receiving grants from Boehringer Ingelheim and Novartis, personal fees from AstraZeneca, and grants and personal fees from GSK, outside the submitted work. Conflict of interest: L. Cazzoletti has nothing to disclose. Conflict of interest: J. Garcia-Aymerich has nothing to disclose. Conflict of interest: M. Holm has nothing to disclose. Conflict of interest: J. Martinez-Moratalla Rovira has nothing to disclose. Conflict of interest: V. Siroux reports receiving speakers’ honoraria from AstraZeneca, Novartis and Teva, outside the submitted work. Conflict of interest: A. Corsico has nothing to disclose. Conflict of interest: A. Marcon has nothing to disclose. Conflict of interest: S. Chanoine reports personal fees for board membership from AstraZeneca, and travel, accommodation and meeting expenses from Boehringer Ingelheim, Actelion Pharmaceuticals and MSD, outside the submitted work. Conflict of interest: J. Quint reports receiving grants from The Health Foundation, the MRC, the British Lung Foundation and IQVIA, grants and advisory board fees from GSK, Boehringer Ingelheim and AstraZeneca, travel fees from Chiesi and Teva, grants and speaking fees from Insmed, grants and consultancy fees from Bayer, outside the submitted work. Conflict of interest: D.S. Ferreira reports receiving grants from the Asthma Foundation of Victoria, Allen and Hanburys, and the National Health and Medical Research Council during the conduct of the study. Conflict of interest: D. Nowak has nothing to disclose. Conflict of interest: A. Malinovschi has nothing to disclose. Conflict of interest: K.A. Franklin has nothing to disclose. Conflict of interest: J. Heinrich has nothing to disclose.
- Published
- 2019
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46. Determination of adjusted reference intervals of urinary biomarkers of oxidative stress in healthy adults using GAMLSS models.
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Chamitava L, Garcia-Larsen V, Cazzoletti L, Degan P, Pasini A, Bellisario V, Corsico AG, Nicolis M, Olivieri M, Pirina P, Ferrari M, Stasinopoulos MD, and Zanolin ME
- Subjects
- 8-Hydroxy-2'-Deoxyguanosine, Adult, Aged, Deoxyguanosine urine, Dinoprost urine, Female, Humans, Logistic Models, Male, Middle Aged, Models, Theoretical, Reference Values, Respiration Disorders diagnosis, Respiration Disorders urine, Seasons, Young Adult, Biomarkers urine, Deoxyguanosine analogs & derivatives, Dinoprost analogs & derivatives, Oxidative Stress
- Abstract
In this study we aimed at identifying main demographic, laboratory and environmental factors influencing the level of urinary biomarkers (DNA-derived 8-oxodG and lipid membrane-derived 8-isoprostane), and deriving their adjusted 95% reference intervals (RI) in a sample of healthy people from the general population. Data from 281 healthy subjects from the Gene Environment Interactions in Respiratory Diseases survey were used in this study. Generalized additive models for location, scale and shape (GAMLSS) were used to find determinants of the biomarkers among gender, age, season and distance from collection (DFC), and to predict their RI. The RI of the biomarkers stratified by season and adjusted for DFC showed a slight statistically significant decrease in the biomarkers at the increasing DFC in two seasons, except the 8-oxodG during the warm season: median levels at the min and max values of DFC were (ng/mgcreat) 7.0-1.1 in the cold and 3.9-3.9 in the warm seasons for 8-oxodG, 0.7-0.2 in the cold and 1.3-0.6 in the warm seasons for 8-isoprostane. Both the biomarkers should be evaluated in association with the DFC and season in large epidemiological studies. The (semi)parametric GAMLSS method is a useful and flexible technique, which makes it possible to estimate adjusted RI., Competing Interests: The previous principal investigator of the GEIRD study Prof. Roberto de Marco (deceased 2015) received a research grant from the “Chiesi Farmaceutici SpA”. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The “Chiesi Farmaceutici SpA”had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. All the authors of this manuscript have no competing interests.
- Published
- 2018
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47. Correction for Parolini et al., "Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity".
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Parolini F, Biswas P, Serena M, Sironi F, Muraro V, Guizzardi E, Cazzoletti L, Scupoli MT, Gibellini D, Ugolotti E, Biassoni R, Beretta A, Malnati M, Romanelli MG, and Zipeto D
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- 2018
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48. Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity.
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Parolini F, Biswas P, Serena M, Sironi F, Muraro V, Guizzardi E, Cazzoletti L, Scupoli MT, Gibellini D, Ugolotti E, Biassoni R, Beretta A, Malnati M, Romanelli MG, and Zipeto D
- Subjects
- Adult, Alleles, Antigen Presentation, Blood Donors, Cell Membrane genetics, Cell Membrane metabolism, Female, HIV Infections virology, HIV-1 pathogenicity, HLA-C Antigens chemistry, HLA-C Antigens immunology, HLA-C Antigens metabolism, Histocompatibility Antigens Class I classification, Histocompatibility Antigens Class I genetics, Histocompatibility Antigens Class I immunology, Humans, Killer Cells, Natural immunology, Male, Middle Aged, T-Lymphocytes, Cytotoxic immunology, Young Adult, beta 2-Microglobulin genetics, beta 2-Microglobulin metabolism, Cell Membrane immunology, HIV Infections immunology, HIV-1 physiology, HLA-C Antigens genetics, Leukocytes, Mononuclear immunology
- Abstract
HLA-C expression is associated with a differential ability to control HIV-1 infection. Higher HLA-C levels may lead to better control of HIV-1 infection through both a higher efficiency of antigen presentation to cytotoxic T lymphocytes and the triggering of activating killer immunoglobulin-like receptors on NK cells, whereas lower levels may provide poor HIV-1 control and rapid progression to AIDS. We characterized the relative amounts of HLA-C heterotrimers (heavy chain/β
2 microglobulin [β2 m]/peptide) and HLA-C free heavy chains on peripheral blood mononuclear cells (PBMCs) from healthy blood donors harboring both alleles with stable or unstable binding to β2 m/peptide. We analyzed the stability of HLA-C heterotrimers of different allotypes and the infectivity of HIV-1 virions produced by PBMCs with various allotypes. We observed significant differences in HLA-C heterotrimer stability and in expression levels. We found that R5 HIV-1 virions produced by PBMCs harboring unstable HLA-C alleles were more infectious than those produced by PBMCs carrying the stable variants. We propose that HIV-1 infectivity might depend both on the amounts of HLA-C molecules and on their stability as trimeric complex. According to this model, individuals with low-expression HLA-C alleles and unstable binding to β2 m/peptide might have worse control of HIV-1 infection and an intrinsically higher capacity to support viral replication. IMPORTANCE Following HIV-1 infection, some people advance rapidly to AIDS while others have slow disease progression. HLA-C, a molecule involved in immunity, is a key determinant of HIV-1 control. Here we reveal how HLA-C variants contribute to the modulation of viral infectivity. HLA-C is present on the cell surface in two different conformations. The immunologically active conformation is part of a complex that includes β2 microglobulin/peptide; the other conformation is not bound to β2 microglobulin/peptide and can associate with HIV-1, increasing its infectivity. Individuals with HLA-C variants with a predominance of immunologically active conformations would display stronger immunity to HIV-1, reduced viral infectivity and effective control of HIV-1 infection, while subjects with HLA-C variants that easily dissociate from β2 microglobulin/peptide would have a reduced immunological response to HIV-1 and produce more infectious virions. This study provides new information that could be useful in the design of novel vaccine strategies and therapeutic approaches to HIV-1., (Copyright © 2017 Parolini et al.)- Published
- 2017
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49. Correction to: Socioeconomic inequalities in smoking habits are still increasing in Italy.
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Verlato G, Accordini S, Nguyen G, Marchetti P, Cazzoletti L, Ferrari M, Antonicelli L, Attena F, Bellisario V, Bono R, Briziarelli L, Casali L, Corsico AG, Fois A, Panico MG, Piccioni P, Pirina P, Villani S, Nicolini G, and de Marco R
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- 2017
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50. The gender, age and risk factor distribution differs in self-reported allergic and non-allergic rhinitis: a cross-sectional population-based study.
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Cazzoletti L, Ferrari M, Olivieri M, Verlato G, Antonicelli L, Bono R, Casali L, Cerveri I, Marchetti P, Pirina P, Rossi A, Villani S, and de Marco R
- Abstract
Background: Few population-based studies have assessed the prevalence and the risk factors of non-allergic rhinitis (NAR) in comparison to allergic rhinitis (AR). Moreover, epidemiologic data on rhinitis in the elderly subjects and in southern Europe are scarce., Objective: This study aimed at estimating the prevalence and at comparing the risk factor distribution of AR and NAR in a general population sample aged 20-84 years in Italy., Methods: A questionnaire on respiratory symptoms and risk factors was administered to random samples of the Italian population aged 20-44 (n = 10,494) 45-64 (n = 2167) and 65-84 (n = 1030) in the frame of the Gene Environment Interactions in Respiratory Diseases (GEIRD) study. Current AR and NAR were defined according to the self-reported presence of nasal allergies or of nasal symptoms without a cold or the flu., Results: NAR showed a significant descending pattern in females from 12.0 % (95 % CI 11.1, 13.1) in the 20-44 year age class, to 7.5 % (5.4, 10.3) in the 65-84 year age class (p = 0.0009), and a roughly stable pattern in males, from 10.2 % (9.3, 11.2) to 11.1 % (8.4, 13.9) (p = 0.5261). AR decreased from 26.6 % (25.7, 27.6) in 20-44 years age class to 15.6 % (13.3, 18.0) in the 65-84 years age class (p < 0.0001), without gender difference. Subjects living near industrial plants and ex- and current smokers had a higher risk of NAR. Current smokers had a lower risk and subjects living in a Mediterranean climate a higher risk of AR., Conclusion: AR and NAR are fairly distinct conditions, as they have a different age, gender and risk factor distribution.
- Published
- 2015
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