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1. Stopping or maintaining oral anticoagulation in patients undergoing photoselective vaporization of the prostate (SOAP) surgery for benign prostate obstruction: study protocol for a multicentre randomized controlled trial

Author

Hélène Charbonneau, Marie Pasquié, Benoit Peyronnet, Aurélien Descazeaud, Nicolas Barry-Delongchamps, Emmanuel Della Negra, Romain Mathieu, Gilles Karsenty, Jean-Alexandre Long, Charles Ballereau, Abdel-Rahmène Azzouzi, Benjamin Pradère, Franck Bruyère, Georges Fournier, Souhil Lebdai, Jehanne Calves, Luc Corbel, Sébastien Vincendeau, Gaelle Fiard, Caroline Thuillier, Jean-Luc Descotes, Pierre Colin, Thibaut Culty, Audrey Hesbois, Valerie Fuzier, Nicolas Savy, Atul Pathak, Pierre Albaladejo, Charles Marc Samama, Felipe Guerrero, and Vincent Misraï

Subjects
Benign prostatic obstruction, GreenLight, Laser, Oral anticoagulation, Complications, Medicine (General), R5-920
Abstract

Abstract Background Lower urinary tract symptoms related to benign prostatic obstruction (BPO) are frequent in men aged > 50 years. Based on the use of innovative medical devices, a number of transurethral ablative techniques have recently been developed for the surgical treatment of BPO. In recent years, GreenLight photoselective vaporization of the prostate (PVP) has been considered as a non-inferior alternative to transurethral resection of the prostate. The GreenLight PVP is usually considered as an interesting surgical option for patients treated via oral anticoagulants (OACs) with regard to its haemostatic properties. The aim of this study was to assess the impact of maintaining OAC treatment in patients undergoing PVP. Methods This study is a multicentre, open-label, randomized controlled trial (RCT) designed to show the non-inferiority of PVP surgery in patients with BPO treated with OACs. This study is designed to enrol 386 OAC-treated patients (treated with vitamin K antagonists and direct oral anticoagulants) who are undergoing PVP for BPO. Patients will be randomized (1:1) to either maintain or stop OAC treatment during the perioperative course. The intervention group will maintain OAC treatment until the day before surgery and resume OAC treatment the day after surgery, whereas the control group will stop OAC treatment (with or without low-molecular-weight heparin bridging therapy) according to the anaesthesia guidelines. The primary outcome of interest to be assessed is the 30-day complications rate according to the Clavien-Dindo classification. The secondary endpoint will examine the 30-day rate of haemorrhagic and thrombotic events. This study will provide 80% power to show non-inferiority, defined as not worse than a 10% (non-inferiority margin) inferior change in the proportion of patients with good outcomes (Clavien-Dindo score

Published
2018
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2. Robot-Assisted Laparoscopic Management of Caliceal Diverticular Calculi

Author

Anneleen Verbrugghe, Loïc Gaillandre, Damien Mouton, Franck Deschildre, Philippe Koenig, Charles Ballereau, and Pierre Colin

Subjects
Calicotomy, Caliceal diverticular calculus, Robot-assisted, Laparoscopy, Urolithiasis, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Standard treatment modalities of caliceal diverticular calculi range from extracorporal shockwave lithotripsy (SWL) over retrograde intrarenal surgery (RIRS), percutaneous nephrolithotomy (PNL) and laparoscopic stone removal. A 55-year-old woman presented with a history of pyelonephritis based on a caliceal diverticular calculus. Due to the narrow infundibulum and anterior location, a robot-assisted laparoscopic calicotomy with extraction of the calculi and fulguration of the diverticulum was performed, with no specific perioperative problems and good stone-free results. This article shows technical feasibility with minimal morbidity of robot-assisted laparoscopic stone removal and obliteration of a caliceal diverticulum.

Published
2017
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3. Robot-Assisted Laparoscopic Management of Caliceal Diverticular Calculi

Author

Damien Mouton, Pierre Colin, Anneleen Verbrugghe, Franck Deschildre, Loïc Gaillandre, Philippe Koenig, and Charles Ballereau

Subjects
medicine.medical_specialty, Urology, medicine.medical_treatment, Calicotomy, lcsh:RC870-923, 03 medical and health sciences, 0302 clinical medicine, Urolithiasis, 030225 pediatrics, medicine, Caliceal diverticular calculus, Percutaneous nephrolithotomy, Laparoscopy, Calculus (medicine), Shockwave lithotripsy, medicine.diagnostic_test, Fulguration, business.industry, Perioperative, Robot-assisted, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, digestive system diseases, Surgery, surgical procedures, operative, Stone removal, business, Endourology, 030217 neurology & neurosurgery, Diverticulum
Abstract

Standard treatment modalities of caliceal diverticular calculi range from extracorporal shockwave lithotripsy (SWL) over retrograde intrarenal surgery (RIRS), percutaneous nephrolithotomy (PNL) and laparoscopic stone removal. A 55-year-old woman presented with a history of pyelonephritis based on a caliceal diverticular calculus. Due to the narrow infundibulum and anterior location, a robot-assisted laparoscopic calicotomy with extraction of the calculi and fulguration of the diverticulum was performed, with no specific perioperative problems and good stone-free results. This article shows technical feasibility with minimal morbidity of robot-assisted laparoscopic stone removal and obliteration of a caliceal diverticulum.

Published
2017

4. Computational analysis of multimorbidity between asthma, eczema and rhinitis

Author

Aguilar, Daniel Pinart, Mariona Koppelman, Gerard H. Saeys, Yvan Nawijn, Martijn C. Postma, Dirkje S. Akdis, Muebeccel and Auffray, Charles Ballereau, Stephane Benet, Marta and Garcia-Aymerich, Judith Ramon Gonzalez, Juan Guerra, Stefano and Keil, Thomas Kogevinas, Manolis Lambrecht, Bart Lemonnier, Nathanael Melen, Erik Sunyer, Jordi Valenta, Rudolf and Valverde, Sergi Wickman, Magnus Bousquet, Jean Oliva, Baldo and Anto, Josep M.

Subjects
immune system diseases
Abstract

Background The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by identifying the proteins and cellular processes that are common to them. Methods An in silico study based on computational analysis of the topology of the protein interaction network was performed in order to characterize the molecular mechanisms of multimorbidity of asthma, eczema and rhinitis. As a first step, proteins associated to either disease were identified using data mining approaches, and their overlap was calculated. Secondly, a functional interaction network was built, allowing to identify cellular pathways involved in allergic multimorbidity. Finally, a network-based algorithm generated a ranked list of newly predicted multimorbidity-associated proteins. Results Asthma, eczema and rhinitis shared a larger number of associated proteins than expected by chance, and their associated proteins exhibited a significant degree of interconnectedness in the interaction network. There were 15 pathways involved in the multimorbidity of asthma, eczema and rhinitis, including IL4 signaling and GATA3-related pathways. A number of proteins potentially associated to these multimorbidity processes were also obtained. Conclusions These results strongly support the existence of an allergic multimorbidity cluster between asthma, eczema and rhinitis, and suggest that type 2 signaling pathways represent a relevant multimorbidity mechanism of allergic diseases. Furthermore, we identified new candidates contributing to multimorbidity that may assist in identifying new targets for multimorbid allergic diseases.

Published
2017

5. Contents Vol. 84, 2010

Author

F. Marchese, J. Zanow, Yoshihisa Kawai, L. Macchione, Vanessa Sandim, J. Masood, Jocelyn M. Rieder, H. Wunderlich, Marc Fourmarier, Kohsuke Sasaki, Rany Shamloul, Tomoyuki Murakami, Nicolas Barry Delongchamps, Yoshiaki Yamamoto, Stephan A. Krueger, O.W. Hakenberg, Christian Schwentner, S. Fuessel, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Jörg Hennenlotter, N. Kroeger, A. Di Benedetto, F. Fraggetta, Kazuhiro Nagao, Gilda Alves, Christian Saussine, Karen Stern, Klaus G. Fink, C. Magno, Charles Ballereau, Claudius Fuellhase, Pascual Chuan-Nuez, Johan Lundin, T. Briggs, José M. Martínez-Jabaloyas, Ursula Kuehs, M. Madonia, Bertrand Lukacs, Donald C. McMillan, Taku Misumi, G. Grasso, Sherif R. Aboseif, John Brusky, Hideyasu Matsuyama, Rashad Mammadov, Harald Trummer, Alexander Winter, Erkan Kismali, Salih Sanlioglu, Aurélien Descazeaud, Viet Tran, Harri Visapää, Omer Kutlu, Adnan Şimşir, I. Petersen, N. Buchholz, Roman Szlauer, Friedhelm Wawroschek, Olivier Haillot, G. Candiano, Badereddin Mohamad Al-Ali, G. Shaw, Francois Desgrandchamps, Denise A. Pereira, Shigeru Sakano, Hideaki Ito, Ahter Dilsad Sanlioglu, Jens Uphoff, Martti Ala-Opas, I. Pirozhok, Luis Arenas, T. Castelli, M.P. Wirth, Arnulf Stenzl, Kazuhiko Nakano, J. Gelister, T. Steiner, Gurhan Gunaydin, F. Aragona, G. Romano, Alexandre de la Taille, Antonio A. Ornellas, Heinz-Peter Schlemmer, Daniela Colleselli, Kazumi Suzuki, Levent A. Guner, Tahir Qayyum, A. Meye, Richard Zigeuner, Satoshi Eguchi, Marian Devonec, Ismail Turker Koksal, David Schilling, Ljiljana Paras, G. Morgia, A. Galia, Rafael Villamón-Fort, Ulrich H. Vogel, P. Pepe, Katsusuke Naito, Cag Cal, M. Gajda, Manuel Gil-Salom, Karl Pummer, Rolf-Peter Henke, A. Papatsoris, U. Settmacher, A. Galì, G. Mucciardi, Tatsuo Morita, Grégoire Robert, Olivier Dumonceau, J. Fichtner, G. Bonvissuto, Ulf-Håkan Stenman, Matthias P. Lichy, Seiji Yano, P A McArdle, and Rahmene Azzouzi

Subjects
Traditional medicine, business.industry, Urology, Medicine, business
Published
2010
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6. Subject Index Vol. 84, 2010

Author

G. Bonvissuto, Rahmene Azzouzi, G. Mucciardi, Tatsuo Morita, Adnan Şimşir, Friedhelm Wawroschek, Olivier Haillot, F. Marchese, Kohsuke Sasaki, Claudius Fuellhase, Pascual Chuan-Nuez, Francois Desgrandchamps, Denise A. Pereira, Olivier Dumonceau, Ursula Kuehs, Omer Kutlu, Tomoyuki Murakami, Seiji Yano, P A McArdle, Shigeru Sakano, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Kazuhiro Nagao, Gilda Alves, J. Fichtner, G. Grasso, Roman Szlauer, I. Pirozhok, Luis Arenas, Marc Fourmarier, Aurélien Descazeaud, A. Papatsoris, Viet Tran, G. Shaw, Stephan A. Krueger, Martti Ala-Opas, S. Fuessel, Donald C. McMillan, Christian Schwentner, Satoshi Eguchi, F. Aragona, Antonio A. Ornellas, N. Buchholz, Klaus G. Fink, Kazumi Suzuki, J. Zanow, Ismail Turker Koksal, J. Gelister, Yoshihisa Kawai, I. Petersen, T. Castelli, Levent A. Guner, Kazuhiko Nakano, T. Steiner, Vanessa Sandim, Richard Zigeuner, Taku Misumi, L. Macchione, Marian Devonec, Johan Lundin, Gurhan Gunaydin, P. Pepe, Tahir Qayyum, A. Meye, John Brusky, Katsusuke Naito, Rany Shamloul, N. Kroeger, Rashad Mammadov, Alexandre de la Taille, A. Di Benedetto, Nicolas Barry Delongchamps, Heinz-Peter Schlemmer, Yoshiaki Yamamoto, Alexander Winter, Cag Cal, Salih Sanlioglu, M. Gajda, José M. Martínez-Jabaloyas, Daniela Colleselli, Rafael Villamón-Fort, Ulrich H. Vogel, Ahter Dilsad Sanlioglu, Jens Uphoff, Christian Saussine, M. Madonia, Charles Ballereau, Bertrand Lukacs, David Schilling, Ljiljana Paras, G. Morgia, G. Candiano, Jörg Hennenlotter, A. Galia, Arnulf Stenzl, Hideyasu Matsuyama, Erkan Kismali, F. Fraggetta, Jocelyn M. Rieder, M.P. Wirth, H. Wunderlich, Harri Visapää, O.W. Hakenberg, Karen Stern, T. Briggs, U. Settmacher, A. Galì, Grégoire Robert, G. Romano, Ulf-Håkan Stenman, Matthias P. Lichy, J. Masood, Karl Pummer, Rolf-Peter Henke, Manuel Gil-Salom, C. Magno, Sherif R. Aboseif, Harald Trummer, Badereddin Mohamad Al-Ali, and Hideaki Ito

Subjects
Gerontology, Index (economics), business.industry, Urology, Medicine, Subject (documents), business
Published
2010
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7. Renal cell carcinoma with rhabdoid features: an aggressive neoplasm with overexpression of p53

Author

David Buob, Charles Ballereau, Xavier Leroy, Laurent Zini, Arnauld Villers, and Sébastien Aubert

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Vimentin, Biology, urologic and male genital diseases, Pathology and Forensic Medicine, Renal cell carcinoma, Eosinophilic, Carcinoma, medicine, Biomarkers, Tumor, Neoplasm, Humans, Carcinoma, Renal Cell, Rhabdoid Tumor, Aged, Neoplasm Staging, Mucin-1, Kidney Carcinoma, Cell Differentiation, General Medicine, Middle Aged, medicine.disease, Prognosis, Intracytoplasmic inclusion, Kidney Neoplasms, Gene Expression Regulation, Neoplastic, Medical Laboratory Technology, biology.protein, Immunohistochemistry, Female, Tumor Suppressor Protein p53
Abstract

Context.—Adult renal cell carcinoma (RCC) with rhabdoid features is a recently recognized morphologic variant of kidney carcinoma. To date, only very few studies have been published on this subject and p53 was not previously studied. Objective.—To evaluate clinical attributes, morphology, and immunohistochemistry in RCC with rhabdoid component. Design.—Reviewing a consecutive series of 310 RCCs, we identified 14 cases of RCC with rhabdoid features. All cases were reviewed and subjected to detailed clinical and pathologic studies with immunohistochemical evaluation of p53. Results.—All tumors were clear RCCs with rhabdoid component representing from 5% to 50% of the tumor volume. Rhabdoid cells were large with a central eosinophilic intracytoplasmic inclusion and an eccentric atypical nucleus. Tumor necrosis was common (13/14) and sometimes extensive. Nine of 14 tumors were staged pT3, 4 of 14 were pT2, and only 1 tumor was pT1. On immunohistochemistry, rhabdoid cells were positive for vimentin (14/ 14), epithelial membrane antigen (11/14), and cytokeratin (9/14). Desmin and smooth muscle actin were always negative. p53 was positive in 10 of 14 tumors in the rhabdoid areas (5%–50% of tumor cells stained) but only in 5 of 14 cases in usual clear renal cell areas. In the follow-up, 10 of 14 patients developed metastases and 6 of 14 died of the disease. The median of survival was 8 months. Conclusions.—We showed that RCC with rhabdoid features is a very aggressive neoplasm with a poor prognosis. We observed an overexpression of p53 in the rhabdoid component that may be implicated in the tumor dedifferentiation.

Published
2006

8. Minimal focus of adenocarcinoma on prostate biopsy: clinicopathological correlations

Author

Charles Ballereau, Xavier Leroy, Arnauld Villers, B Gosselin, David Augusto, and Sébastien Aubert

Subjects
Male, Pathology, medicine.medical_specialty, Prostate biopsy, medicine.medical_treatment, Short Report, Adenocarcinoma, Gleason Score 6, Pathology and Forensic Medicine, Prostate cancer, Prostate, Biopsy, medicine, Humans, Aged, Prostatectomy, medicine.diagnostic_test, business.industry, Biopsy, Needle, Prostatic Neoplasms, General Medicine, Middle Aged, medicine.disease, digestive system diseases, medicine.anatomical_structure, High Grade Intraepithelial Neoplasia, business
Abstract

Aims: To establish the clinicopathological features of minimal volume prostate adenocarcinoma on prostate biopsy. Methods: Twenty four cases of minimal adenocarcinoma diagnosed on prostate biopsy and treated by radical prostatectomy were reviewed. Results: The major microscopic criteria were nuclear enlargement (22 of 24), infiltrative pattern (19 of 24), prominent nucleoli (19 of 24), intraluminal eosinophilic secretions (15 of 24), and high grade intraepithelial neoplasia associated (11 of 24). Sixteen of 24 cases were assigned a Gleason score 6 on biopsy. When the whole gland was assessed, 22 of these tumours were localised to the prostate (stage pT2), and only two cases were stage pT3. Conclusions: Minimal focus of adenocarcinoma on prostate biopsy is not an uncommon finding. It is usually an intermediate grade and localised stage neoplasm.

Published
2003

9. Retraction of Authorship

Author

A. Papatsoris, Taku Misumi, Tomoyuki Murakami, Tahir Qayyum, A. Meye, Viet Tran, Rahmene Azzouzi, Kazuhiro Nagao, Gilda Alves, Arnulf Stenzl, Kohsuke Sasaki, F. Marchese, Cag Cal, M. Gajda, Rashad Mammadov, Kristina Hotakainen, I. Ioannou, Takahiko Hara, Jörg Hennenlotter, Donald C. McMillan, Heinz-Peter Schlemmer, David Schilling, Ljiljana Paras, G. Morgia, Marian Devonec, Christian Saussine, Shigeru Sakano, Omer Kutlu, Ulf-Håkan Stenman, Hideyasu Matsuyama, Daniela Colleselli, Adnan Şimşir, Olivier Dumonceau, I. Pirozhok, Luis Arenas, José M. Martínez-Jabaloyas, Satoshi Eguchi, Matthias P. Lichy, Erkan Kismali, Friedhelm Wawroschek, Badereddin Mohamad Al-Ali, J. Masood, J. Fichtner, Roman Szlauer, M. Madonia, Claudius Fuellhase, Olivier Haillot, F. Aragona, M.P. Wirth, Charles Ballereau, Antonio A. Ornellas, Karl Pummer, Bertrand Lukacs, Pascual Chuan-Nuez, Manuel Gil-Salom, Alexander Winter, A. Galia, Francois Desgrandchamps, Denise A. Pereira, G. Mucciardi, Kazumi Suzuki, Tatsuo Morita, Levent A. Guner, Ismail Turker Koksal, Kazuhiko Nakano, Martti Ala-Opas, Marc Fourmarier, Ursula Kuehs, I. Petersen, T. Steiner, Salih Sanlioglu, Rolf-Peter Henke, G. Bonvissuto, J. Gelister, Richard Zigeuner, T. Castelli, Hideaki Ito, F. Fraggetta, U. Settmacher, A. Galì, G. Shaw, Christian Schwentner, Stephan A. Krueger, Alexandre de la Taille, Gurhan Gunaydin, G. Candiano, S. Fuessel, Ahter Dilsad Sanlioglu, Jens Uphoff, Vanessa Sandim, Grégoire Robert, P. Pepe, Katsusuke Naito, Sherif R. Aboseif, Harri Visapää, G. Grasso, Harald Trummer, Seiji Yano, P A McArdle, Nicolas Barry Delongchamps, Rafael Villamón-Fort, Yoshiaki Yamamoto, Ulrich H. Vogel, John Brusky, Aurélien Descazeaud, C. Magno, Klaus G. Fink, N. Buchholz, J. Zanow, Johan Lundin, L. Macchione, G. Romano, T. Briggs, Jocelyn M. Rieder, H. Wunderlich, O.W. Hakenberg, Karen Stern, Yoshihisa Kawai, Rany Shamloul, N. Kroeger, and A. Di Benedetto

Subjects
business.industry, Urology, Medicine, Engineering ethics, business
Published
2010
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