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222 results on '"Chen, Chunhong"'

12. Colistin Induces Oxidative Stress and Apoptotic Cell Death through the Activation of the AhR/CYP1A1 Pathway in PC12 Cells.

Author

Xie, Baofu, Liu, Yue, Chen, Chunhong, Velkov, Tony, Tang, Shusheng, Shen, Jianzhong, and Dai, Chongshan

Subjects
REACTIVE oxygen species, MEMBRANE potential, GENE expression, COLISTIN, CELL death
Abstract

Colistin is commonly regarded as the "last-resort" antibiotic for combating life-threatening infections caused by multidrug-resistant (MDR) gram-negative bacteria. Neurotoxicity is a potential adverse event associated with colistin application in clinical settings, yet the exact molecular mechanisms remain unclear. This study examined the detrimental impact of colistin exposure on PC12 cells and the associated molecular mechanisms. Colistin treatment at concentrations of 0–400 μM decreased cell viability and induced apoptotic cell death in both time- and concentration-dependent manners. Exposure to colistin triggered the production of reactive oxygen species (ROS) and caused oxidative stress damage in PC12 cells. N-acetylcysteine (NAC) supplementation partially mitigated the cytotoxic and apoptotic outcomes of colistin. Evidence of mitochondrial dysfunction was observed through the dissipation of membrane potential. Additionally, colistin treatment upregulated the expression of AhR and CYP1A1 mRNAs in PC12 cells. Pharmacological inhibition of AhR (e.g., using α-naphthoflavone) or intervention with the CYP1A1 gene significantly decreased the production of ROS induced by colistin, subsequently lowering caspase activation and cell apoptosis. In conclusion, our findings demonstrate, for the first time, that the activation of the AhR/CYP1A1 pathway contributes partially to colistin-induced oxidative stress and apoptosis, offering insights into the cytotoxic effects of colistin. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Influence of Nano-SiO 2 Content on Cement Paste and the Interfacial Transition Zone.

Author

Zhang, Shaofeng, Liu, Ronggui, Lu, Chunhua, Hong, Junqing, Chen, Chunhong, and Xu, Jiajing

Subjects
DIGITAL image correlation, CEMENT, PASTE, ELASTIC modulus
Abstract

Nano-SiO2 (NS) is widely used in cement-based materials due to its excellent physical properties. To study the influence of NS content on a cement paste and the interfacial transition zone (ITZ), cement paste samples containing nano content ranging from 0 to 2% (by weight of cement) were prepared, and digital image correlation (DIC) technology was applied to test the mechanical properties. Finally, the optimal NS content was obtained with statistical analysis. The mini-slump cone test showed that, with the help of superplasticizer and ultrasonic treatment, the flowability decreased continuously, as the NS content increased. The DIC experimental results showed that NS could effectively improve the mechanical properties of the cement paste and the ITZ. Specifically, at the content level of 1%, the elastic modulus of cement paste and ITZ was 20.95 GPa and 3.20 GPa, respectively. When compared to that without nanomaterials, the increased amplitude was 73.50% and 90.50%, respectively. However, with the further increase in NS content, the mechanical properties decreased, which was mainly caused by the agglomeration of nanomaterials. Additionally, the NS content did not exhibit a significant effect on the thickness of the ITZ, and its value was maintained at 76.91–91.38 μm. SEM confirmed that NS would enhance the microstructure of both cement paste and ITZ. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Reversible hydrogen spillover in Ru-WO₃₋ₓ enhances hydrogen evolution activity in neutral pH water splitting

Author

Chen, Jiadong, Chen, Chunhong, Qin, Minkai, Li, Ben, Lin, Binbin, Mao, Qing, Yang, Hongbin, Liu, Bin, Wang, Yong, School of Physical and Mathematical Sciences, and School of Chemical and Biomedical Engineering

Subjects
Electrokinesis, Chemical engineering [Engineering], Hydrogen
Abstract

Noble metal electrocatalysts (e.g., Pt, Ru, etc.) suffer from sluggish kinetics of water dissociation for the electrochemical reduction of water to molecular hydrogen in alkaline and neutral pH environments. Herein, we found that an integration of Ru nanoparticles (NPs) on oxygen-deficient WO3-x manifested a 24.0-fold increase in hydrogen evolution reaction (HER) activity compared with commercial Ru/C electrocatalyst in neutral electrolyte. Oxygen-deficient WO3-x is shown to possess large capacity for storing protons, which could be transferred to the Ru NPs under cathodic potential. This significantly increases the hydrogen coverage on the surface of Ru NPs in HER and thus changes the rate-determining step of HER on Ru from water dissociation to hydrogen recombination. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Published version We are grateful for the financial support from the National Key R&D Program of China (2021YFB3801600), the National Natural Science Foundation of China (21872121, 21908189), the Fundamental Research Funds for the Central Universities (2017XZZX002−16), Ministry of Education of Singapore (Tier 1: RG4/20 and Tier 2: MOET2EP10120-0002), and Agency for Science, Technology and Research (AME IRG: A20E5c0080).

Published
2022

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