Search

Your search keyword '"Cheng, Shipeng"' showing total 43 results
Start Over Author "Cheng, Shipeng" Search Limiters Full Text
43 results on '"Cheng, Shipeng"'

3. The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation

Author

Gu, Wangpeng, Zhang, Jia, Li, Qing, Zhang, Yaguang, Lin, Xuan, Wu, Bingbing, Yin, Qi, Sun, Jinqiao, Lu, Yulan, Sun, Xiaoyu, Jia, Caiwei, Li, Chuanyin, Zhang, Yu, Wang, Meng, Yin, Xidi, Wang, Su, Xu, Jiefang, Wang, Ran, Zhu, Songling, Cheng, Shipeng, Chen, Shuangfeng, Liu, Lian, Zhu, Lin, Yan, Chenghua, Yi, Chunyan, Li, Xuezhen, Lian, Qiaoshi, Lin, Guomei, Ling, Zhiyang, Ma, Liyan, Zhou, Min, Xiao, Kuanlin, Wei, Haiming, Hu, Ronggui, Zhou, Wenhao, Ye, Lilin, Wang, Haikun, Li, Jinsong, and Sun, Bing

Published
2023
Full Text
View/download PDF

7. Cancer metabolism and tumor microenvironment: fostering each other?

Author

Yuan, Yiyuan, Li, Huimin, Pu, Wang, Chen, Leilei, Guo, Dong, Jiang, Hongfei, He, Bo, Qin, Siyuan, Wang, Kui, Li, Na, Feng, Jingwei, Wen, Jing, Cheng, Shipeng, Zhang, Yaguang, Yang, Weiwei, Ye, Dan, Lu, Zhimin, Huang, Canhua, Mei, Jun, Zhang, Hua-Feng, Gao, Ping, Jiang, Peng, Su, Shicheng, Sun, Bing, and Zhao, Shi-Min

Published
2022
Full Text
View/download PDF

21. Cancer metabolism and tumor microenvironment: fostering each other?

Author

Yuan, Yiyuan, primary, Li, Huimin, additional, Pu, Wang, additional, Chen, Leilei, additional, Guo, Dong, additional, Jiang, Hongfei, additional, He, Bo, additional, Qin, Siyuan, additional, Wang, Kui, additional, Li, Na, additional, Feng, Jingwei, additional, Wen, Jing, additional, Cheng, Shipeng, additional, Zhang, Yaguang, additional, Yang, Weiwei, additional, Ye, Dan, additional, Lu, Zhimin, additional, Huang, Canhua, additional, Mei, Jun, additional, Zhang, Hua-Feng, additional, Gao, Ping, additional, Jiang, Peng, additional, Su, Shicheng, additional, Sun, Bing, additional, and Zhao, Shi-Min, additional

Published
2021
Full Text
View/download PDF

22. Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO

Author

Linzhu Ren, Yucheng Zhou, Lianjiang Qiao, Cheng Shipeng, Jing Qian, Yanling Yang, Cheng Yuening, Xinglong Wang, Zhaoyang Bu, and Sen Yang

Subjects
UTP-Glucose-1-Phosphate Uridylyltransferase, Veterinary medicine, Brucellosis, chemistry.chemical_compound, Mice, Ubiquitin, Western blot, Bacterial Proteins, SF600-1100, medicine, Brucella melitensis, Animals, UTP-glucose-1-phosphate uridylyltransferase (UGPase), General Veterinary, biology, medicine.diagnostic_test, Chemistry, Kinase, Ubiquitination, NF-kappa B, Nuclear factor-kappa enhancer-binding protein (NF-κB), NF-κB, General Medicine, biology.organism_classification, Cell biology, I-kappa B Kinase, IκBα, RAW 264.7 Cells, Gene Expression Regulation, biology.protein, Phosphorylation, Signal transduction, Research Article, Signal Transduction
Abstract

Background UTP-glucose-1-phosphoryl transferase (UGPase) catalyzes the synthesis of UDP-glucose, which is essential for generating the glycogen needed for the synthesis of bacterial lipopolysaccharide (LPS) and capsular polysaccharide, which play important roles in bacterial virulence. However, the molecular function of UGPase in Brucella is still unknown. Results In this study, the ubiquitination modification of host immune-related protein in cells infected with UGPase-deleted or wild-type Brucella was analyzed using ubiquitination proteomics technology. The ubiquitination modification level and type of NF-κB Essential Modulator (NEMO or Ikbkg), a molecule necessary for NF-κB signal activation, was evaluated using Coimmunoprecipitation, Western blot, and dual-Luciferase Assay. We found 80 ubiquitin proteins were upregulated and 203 ubiquitin proteins were downregulated in cells infected with B. melitensis 16 M compared with those of B. melitensis UGPase-deleted strain (16 M-UGPase−). Moreover, the ubiquitin-modified proteins were mostly enriched in the categories of regulation of kinase/NF-κB signaling and response to a bacterium, suggesting Brucella UGPase inhibits ubiquitin modification of related proteins in the host NF-κB signaling pathway. Further analysis showed that the ubiquitination levels of NEMO K63 (K63-Ub) and Met1 (Met1-Ub) were significantly increased in the 16 M-UGPase−-infected cells compared with that of the 16 M-infected cells, further confirming that the ubiquitination levels of NF-κB signaling-related proteins were regulated by the bacterial UGPase. Besides, the expression level of IκBα was decreased, but the level of p-P65 was significantly increased in the 16 M-UGPase−-infected cells compared with that of the 16 M- and mock-infected cells, demonstrating that B. melitensis UGPase can significantly inhibit the degradation of IκBα and the phosphorylation of p65, and thus suppressing the NF-κB pathway. Conclusions The results of this study showed that Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO, which will provide a new scientific basis for the study of immune mechanisms induced by Brucella.

Published
2021

23. Group 2 innate lymphoid cells boost CD8+ T-cell activation in anti-tumor immune responses.

Author

Wen, Jing, Cheng, Shipeng, Wang, Ran, Huang, Yuying, Xu, Long, Ma, Liyan, Ling, Zhiyang, Xu, Jinfu, Zhao, Deping, Zhang, Yaguang, and Sun, Bing

Subjects
*INNATE lymphoid cells, *IMMUNE response, *T cells, *CELL physiology, *ANTIGEN processing
Abstract

Group 2 innate lymphoid cells (ILC2s) are essential for orchestrating type 2 immune responses during allergic airway inflammation and infection. ILC2s have been reported to play a regulatory role in tumors; however, this conclusion is controversial. In this study, we showed that IL-33-activated ILC2s could boost CD8+ T-cell function through direct antigen cross-presentation. After activation by IL-33, ILC2s showed an enhanced potential to process antigens and prime CD8+ T cell activation. Activated ILC2s could phagocytose exogenous antigens in vivo and in vitro, promoting antigen-specific CD8+ T cell function to enhance antitumor immune responses. Administration of OVA-loaded ILC2s induces robust antitumor effects on the OVA-expressing tumor model. These findings suggested that the administration of tumor antigen-loaded ILC2s might serve as a potential strategy for cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

28. Evidence for natural recombination between mink enteritis virus and canine parvovirus

Author

Wang Jianke, Cheng Shipeng, Yi Li, Cheng Yuening, Yang Shen, Xu Hongli, Zhao Hang, Yan Xijun, and Wu Hua

Subjects
Parvovirus, Mink enteritis virus, Recombination, Infectious and parasitic diseases, RC109-216
Abstract

Abstract A virus was isolated from mink showing clinical and pathological signs of enteritis in China. This virus, designated MEV/LN-10, was identified as mink enteritis virus (MEV) based on its cytopathic effect in the feline F81 cell line, the hemagglutination (HA) and hemagglutination inhibition (HI) assay, electron microscopy (EM) and animal infection experiments. The complete viral genome was cloned and sequenced. Phylogenetic and recombination analyses on the complete MEV/LN-10 genome showed evidence of recombination between MEV and canine parvovirus (CPV). The genome was composed of the NS1 gene originating from CPV while the VP1 gene was of MEV origin. This is the first demonstration of recombination between a CPV and MEV in nature. Our findings not only provide valuable evidence indicating that recombination is an important genetic mechanism contributing to the variation and evolution of MEV, but also that heterogeneous recombination can occur in the feline parvovirus subspecies.

Published
2012
Full Text
View/download PDF

29. Mink Circovirus Can Infect Minks, Foxes and Raccoon Dogs

Author

Nan Li, Haiwei Zhang, Yang Yanling, Guo Li, Cheng Yuening, Xinyuan Zhang, Yucheng Zhou, Linzhu Ren, and Cheng Shipeng

Subjects
0301 basic medicine, Circovirus, Diarrhea, medicine.medical_specialty, China, Letter, Immunology, Foxes, Mink circovirus, 03 medical and health sciences, Medical microbiology, Virology, biology.animal, medicine, Animals, Mink, Circoviridae Infections, biology, Coinfection, Raccoon Dogs, medicine.disease, 030104 developmental biology, Molecular Medicine
Published
2018

32. Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates

Author

Yi, Li, primary, Cao, Zhigang, additional, Tong, Mingwei, additional, Cheng, Yuening, additional, Yang, Yong, additional, Li, Shuang, additional, Wang, Jianke, additional, Lin, Peng, additional, Sun, Yaru, additional, Zhang, Miao, additional, and Cheng, Shipeng, additional

Published
2017
Full Text
View/download PDF

34. Phylogenetic features of hemagglutin gene in canine distemper virus strains from different genetic lineages

Author

Liao, Peng, Guo, Li, Wen, Yongjun, Yang, Yangling, and Cheng, Shipeng

Subjects
Original Article
Abstract

In the present study, the genotype of two Canine distemper virus (CDV) strains, namely, ZJJ-SD and ZJJ-LN, were investigated, based on the whole hemagglutinin (HA) gene. The CDV strains were obtained from two foxes in Shandong Province and Liaoning Province in 2011. Phylogenetic analyses were carried out for 260 CDV strains worldwide, and a statistical analysis was performed in the amino acid substitutions at positions 530 and 549 of the HA protein. Phylogenetic analyses revealed that the two strains, ZJJ-SD and ZJJ-LN, belonged to the CDV Asia I lineage. Site 530 of HA protein was found to be relatively conserved within CDV lineages in different host species by combining the genetic sequence data with the published data from 260 CDV strains worldwide. The data analysis showed a bias toward the predicted substitution Y549H for the non-dog strains in Asia I and Europe lineages. The ratio of site 549 genetic drift in the HA gene were significantly different between dogs and non-dogs in the two lineages. The strain ZJJ-SD, from wild canid, has an Y549H substitution. It is one of three Y549H substitution for wild canids in Asia I lineages. Site 530 of HA protein was not immediately relative to CDV genetic drift from dogs to non-dogs. Statistical analysis indicated that non-dog strains have a high probability to contain Y549H than dog strains in Asia I and Europe lineages. Thus, site 549 is considered important in genetic drift from dogs to non-dogs, at least in Asia I and Europe lineages.

Published
2015

35. Group 2 innate lymphoid cells boost CD8+T-cell activation in anti-tumor immune responses

Author

Wen, Jing, Cheng, Shipeng, Wang, Ran, Huang, Yuying, Xu, Long, Ma, Liyan, Ling, Zhiyang, Xu, Jinfu, Zhao, Deping, Zhang, Yaguang, and Sun, Bing

Abstract

ABSTRACTGroup 2 innate lymphoid cells (ILC2s) are essential for orchestrating type 2 immune responses during allergic airway inflammation and infection. ILC2s have been reported to play a regulatory role in tumors; however, this conclusion is controversial. In this study, we showed that IL-33-activated ILC2s could boost CD8+T-cell function through direct antigen cross-presentation. After activation by IL-33, ILC2s showed an enhanced potential to process antigens and prime CD8+T cell activation. Activated ILC2s could phagocytose exogenous antigens in vivoand in vitro, promoting antigen-specific CD8+T cell function to enhance antitumor immune responses. Administration of OVA-loaded ILC2s induces robust antitumor effects on the OVA-expressing tumor model. These findings suggested that the administration of tumor antigen-loaded ILC2s might serve as a potential strategy for cancer treatment.

Published
2023
Full Text
View/download PDF

42. Group 2 innate lymphoid cells boost CD8 + T-cell activation in anti-tumor immune responses.

Author

Wen J, Cheng S, Wang R, Huang Y, Xu L, Ma L, Ling Z, Xu J, Zhao D, Zhang Y, and Sun B

Subjects
Humans, Interleukin-33, Inflammation, CD8-Positive T-Lymphocytes, Immunity, Innate, Lymphocytes
Abstract

Group 2 innate lymphoid cells (ILC2s) are essential for orchestrating type 2 immune responses during allergic airway inflammation and infection. ILC2s have been reported to play a regulatory role in tumors; however, this conclusion is controversial. In this study, we showed that IL-33-activated ILC2s could boost CD8 + T-cell function through direct antigen cross-presentation. After activation by IL-33, ILC2s showed an enhanced potential to process antigens and prime CD8 + T cell activation. Activated ILC2s could phagocytose exogenous antigens in vivo and in vitro , promoting antigen-specific CD8 + T cell function to enhance antitumor immune responses. Administration of OVA-loaded ILC2s induces robust antitumor effects on the OVA-expressing tumor model. These findings suggested that the administration of tumor antigen-loaded ILC2s might serve as a potential strategy for cancer treatment., Competing Interests: No potential conflict of interest was reported by the authors., (© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.)

Published
2023
Full Text
View/download PDF

43. Complete genome sequence of a highly pathogenic porcine reproductive and respiratory syndrome virus NM1 strain from northern China.

Author

Li Z, Leng X, Qi Q, Wang F, Wen Y, Tan B, He Y, Xia M, Lu W, Chen L, Cheng S, and Wu H

Subjects
Animals, China, Molecular Sequence Data, Porcine respiratory and reproductive syndrome virus pathogenicity, Sequence Deletion, Genome, Viral, Porcine respiratory and reproductive syndrome virus genetics
Abstract

NM1 is a highly pathogenic North American-type porcine reproductive and respiratory syndrome virus (PRRSV). The complete genome sequence shows that NM1 shares high sequence identity (99.2 to 99.4%) to other HP-PRRSV isolates, containing two discontinuous deletions, a 1-amino-acid deletion at position 481 and a 29-amino-acid deletion at positions 533 to 651, in nonstructural protein 2.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results