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15 results on '"Cheng, Yuxia"'

1. A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC

Author

Li, Zhuoqi, primary, Zheng, Chunning, additional, Liu, Hongtao, additional, Lv, Jiling, additional, Wang, Yuanyuan, additional, Zhang, Kai, additional, Kong, Shuai, additional, Chen, Feng, additional, Kong, Yongmei, additional, Yang, Xiaowei, additional, Cheng, Yuxia, additional, Yang, Zhensong, additional, Zhang, Chi, additional, and Tian, Yuan, additional

Published
2023
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8. Differences in initial versus recurrent diabetic foot ulcers at a specialized tertiary diabetic foot care center in China

Author

Lintao Shi, Jie Zhao, Ping Zu, Mei Zhang, Aihong Wang, Cheng Yuxia, and Hongyan Shi

Subjects
medicine.medical_specialty, Medicine (General), China, recurrence, medicine.medical_treatment, 030209 endocrinology & metabolism, Diabetic foot ulcer, 030204 cardiovascular system & hematology, Biochemistry, Amputation, Surgical, 03 medical and health sciences, 0302 clinical medicine, R5-920, Risk Factors, Internal medicine, callus, amputation, medicine, Diabetes Mellitus, Humans, Risk factor, business.industry, Biochemistry (medical), Diabetic foot care, vascular intervention, Cell Biology, General Medicine, medicine.disease, Diabetic foot, Diabetic Foot, Amputation, risk factor, business, Retrospective Clinical Research Report
Abstract

Objective To investigate the characteristics of diabetic foot ulcer (DFU) recurrence. Methods A total of 573 patients with DFUs were recruited and divided into an initial group (395 patients) and a recurrence group (178 patients). The factors related to recurrence were analyzed using multivariate regression. Results The recurrence group had longer diabetes duration (odds ratio [OR] 192; 95% confidence interval 120, 252 vs. 156; 96, 240); lower glycated hemoglobin levels (OR 8.1; 95% CI 6.8, 9.6 vs. 9.1; 7.4, 10.5), and higher rates than the initial group of amputation (37.5% vs. 2.0%), history of vascular intervention (21.3% vs. 3.9%), retinopathy (77.7% vs. 64.7%), callus (44.4% vs. 20.8%), foot deformity (51.2% vs. 24.6%), and outdoor sports shoe wearing (34.0% vs. 21.2%). Multiple factor logistic regression analysis showed that diabetes duration (OR 1.004), callus (OR 2.769), vascular intervention (OR 2.824) and amputation (OR 22.256) were independent risk factors for DFU recurrence. Conclusion Diabetes duration, callus, history of vascular intervention, and amputation were independent risk factors for recurrent DFUs in a cohort of Chinese patients with active DFU. The prevention and treatment of DFUs, especially callus treatment, foot care, and blood glucose control, should be improved in China.

Published
2021

13. Development and validation of a brief diabetic foot ulceration risk checklist among diabetic patients: a multicenter longitudinal study in China

Author

Zhou, Qiuhong, primary, Peng, Min, additional, Zhou, Lihuan, additional, Bai, Jiaojiao, additional, Tong, Ao, additional, Liu, Min, additional, Ng, In I, additional, Cheng, Yuxia, additional, Cai, Yunmin, additional, Yang, Yujin, additional, Chen, Yilian, additional, Gao, Suwen, additional, Li, Zhong, additional, Fu, Xiaoai, additional, Shen, Minxue, additional, Zhang, Jianglin, additional, and Chen, Xiang, additional

Published
2018
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15. The lipid peroxidation-derived DNA adduct γ-OHPdG as a diagnostic and prognostic biomarker in hepatocellular carcinoma.

Author

Cao Q, Zhang Y, Liu H, Cheng Y, Liu M, Zhao H, Tang R, Sun J, Xu S, Sun B, and Sun Q

Subjects
Humans, DNA Adducts, Prognosis, Lipid Peroxidation, Prospective Studies, Liver Cirrhosis diagnosis, Liver Cirrhosis complications, Biomarkers, Biomarkers, Tumor genetics, Carcinoma, Hepatocellular genetics, Liver Neoplasms genetics
Abstract

Purpose: Chronic inflammation and lipid peroxidation (LPO) are associated with the pathogenesis of hepatocellular carcinoma (HCC), and γ-hydroxy-1, N 2 -propanodeoxyguanosine (γ-OHPdG) is a promutagenic DNA adduct derived from LPO. This study aimed to examine the relationship between γ-OHPdG and the progression of liver carcinogenesis., Methods: Primary HCC specimens were obtained from 228 patients and cirrhosis specimens from 46 patients. The patients were followed up with after surgery via outpatient visits and telephone calls. The levels of γ-OHPdG were determined by immunohistochemical analysis in the carcinomatous tissues together with adjacent and cirrhosis tissues., Results: γ-OHPdG levels in the cancerous tissues were significantly higher compared to adjacent tissues (P < 0.001) and also higher than the ones from the tissues of cirrhosis patients. Along with tumor size, histological grade, MVI grade, T stage, the percentage of ki67-positive cells and HCC progression, γ-OHPdG levels in cancerous tissues showed a gradually increasing trend. Moreover, prognostic analysis showed that higher γ-OHPdG levels in cancerous tissues were strongly correlated with lower overall survival (P < 0.001), lower intrahepatic recurrence-free survival (P < 0.001) and lower distant metastasis-free survival (P < 0.05). There was a trend, although not statistically significant, of increased levels of γ-OHPdG in cirrhosis cases that advanced to HCC, whereas γ-OHPdG levels reversely correlated with the period of time observed for cirrhosis advanced to HCC., Conclusions: These results suggest that γ-OHPdG is a prognostic biomarker for predicting outcomes in HCC, and may serve as a prospective indicator for predicting HCC in cirrhosis patients.

Published
2023
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