1. Maternal HBV Viremia and Association With Adverse Infant Outcomes in Women Living With HIV and HBV.
- Author
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Bhattacharya, Debika, Guo, Rong, Tseng, Chi-Hong, Emel, Lynda, Sun, Ren, Chiu, Shih-Hsin, Stranix-Chibanda, Lynda, Chipato, Tsungai, Mohtashemi, Neaka Z, Kintu, Kenneth, Manji, Karim P, Moodley, Dhayendre, Thio, Chloe L, Maldonado, Yvonne, and Currier, Judith S
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Pediatric AIDS ,Hepatitis ,Hepatitis - B ,HIV/AIDS ,Clinical Trials and Supportive Activities ,Infant Mortality ,Perinatal Period - Conditions Originating in Perinatal Period ,Prevention ,Pediatric ,Infectious Diseases ,Clinical Research ,Liver Disease ,Digestive Diseases ,Aetiology ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,2.2 Factors relating to the physical environment ,Infection ,Reproductive health and childbirth ,Good Health and Well Being ,Anti-HIV Agents ,Birth Weight ,Coinfection ,Double-Blind Method ,Female ,HIV Infections ,HIV-1 ,Hepatitis B ,Hepatitis B virus ,Humans ,Infectious Disease Transmission ,Vertical ,Nevirapine ,Pregnancy ,Viral Load ,Viremia ,pregnancy ,low birth weight ,hepatitis B virus viral load ,HIV/hepatitis B virus coinfection ,Sub-saharan Africa ,Paediatrics and Reproductive Medicine ,Public Health and Health Services ,Pediatrics ,Clinical sciences ,Paediatrics - Abstract
BackgroundThere is limited information on perinatal outcomes in HIV-hepatitis B virus (HBV) coinfection.MethodsHIV Prevention Trials Network (HPTN) 046 was a randomized double-blind placebo-controlled trial of perinatal transmission that evaluated 6 months of infant nevirapine versus placebo among breast-fed infants. Women living with HIV and their infants enrolled in sub-Saharan Africa from 2007 to 2010; 78% received antiretroviral therapy (ART). Maternal samples were tested for hepatitis B surface antigen (HBsAg). High and low HBV viral load (VL) was defined as ≥106 IU/mL and
- Published
- 2021