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3. GBDTMO: as new option for early-stage breast cancer detection and classification using machine learning

Author

Vibith A. S. and Jobin Christ M C

Subjects
Breast cancer, machine learning, accuracy, classification, ensemble, Mayfly search, Control engineering systems. Automatic machinery (General), TJ212-225, Automation, T59.5
Abstract

Breast cancer is the second leading cause of disease death in women, after lung and bronchus cancer. According to measurements, mammography misses breast cancer in 10% to 15% of cases for women aged 50 to 69 years. In the current study, we used the Wisconsin breast cancer dataset to develop a two-stage model for breast cancer diagnosis. The main goal of this study effort is to effectively carry out feature selection and classification tasks. Gradient Boosting Decision Tree-based Mayfly Optimisation (GBDTMO), an innovative and efficient breast cancer diagnostic machine learning system, is provided. In the second stage, we employ a Mayfly search to determine which subset of traits is the best. Two more well-known datasets on breast cancer, the ICCR and the Cancer Corpus, were also compared for classification accuracy. The accuracy of the suggested GBDTMO model was higher than that of the existing GBDT and Practical Federated Gradient Boosting Decision Tree (PFGBDT), which had accuracy values of 93.25% and 94.25%, respectively. Similarly, the recall, F-measure, and ROC area values were 98.52%, 97.52%, and 96.32%, respectively. Furthermore, it demonstrated a lower RMSE of 0.98 than the existing GBDT and PFGBDT.

Published
2023
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4. Production of Sigma{\pm}pi?pK+ in p+p reactions at 3.5 GeV beam energy

Author

Agakishiev, G., Balanda, A., Belver, D., Belyaev, A., Berger-Chen, J. C., Blanco, A., Boehmer, M., Boyard, J. L., Cabanelas, P., Castro, E., Chernenko, S., Destefanis, T. Christ M., Dohrmann, F., Dybczak, A., Epple, E., Fabbietti, L., Fateev, O., Finocchiaro, P., Fonte, P., Friese, J., Fröhlich, I., Galatyuk, T., Garzon, J. A., Gernhäuser, R., Gilardi, C., Golubeva, M., Gonza'lez-Di'az, D., Guber, F., Gumberidze, M., Heinz, T., Hennino, T., Holzmann, R., Ierusalimov, A., Iori, I., Ivashkin, A., Jurkovic, M., Kämpfer, B., Kanaki, K., Karavicheva, T., Koenig, I., Koenig, W., Kolb, B. W., Kotte, R., Kr'asa, A., Krizek, F., Krücken, R., Kuc, H., Kuehn, W., Kugler, A., Kurepin, A., Lalik, R., Lang, S., Lange, J. S., Lapidus, K., Liu, T., Lopes, L., Lorenz, M., Maier, L., Mangiarotti, A., Markert, J., Metag, V., Michalska, B., Michel, J., Morinie're, E., Mousa, J., Müntz, C., Naumann, L., Otwinowski, J., Pachmayer, Y. C., Palka, M., Parpottas, Y., Pechenov, V., Pechenova, O., Pietraszko, J., Przygoda, W., Ramstein, B., Reshetin, A., Rustamov, A., Sadovsky, A., Salabura, P., Schmah, A., Schwab, E., Siebenson, J., Sobolev, Yu. G., Spataro, S., Spruck, B., Ströbele, H., Stroth, J., Sturm, C., Tarantola, A., Teilab, K., Tlusty, P., Traxler, M., Trebacz, R., Tsertos, H., Wagner, V., Weber, M., Wendisch, C., Wüstenfeld, J., Yurevich, S., and Zanevsky, Y.

Subjects
Nuclear Experiment
Abstract

We study the production of Sigma^+-pi^+-pK^+ particle quartets in p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the HADES experiment at GSI. This report evaluates the contribution of resonances like Lambda(1405$, Sigma(1385)^0, Lambda(1520), Delta(1232), N^* and K^*0 to the Sigma^+- pi^-+ p K+ final state. The resulting simulation model is compared to the experimental data in several angular distributions and it shows itself as suitable to evaluate the acceptance corrections properly., Comment: 15 pages, 5 figures

Published
2012
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7. Chest pain in patients with cancer: prevalence of myocardial infarction and diagnostic performance of high-sensitivity cardiac troponin T/I

Author

Bima, P, primary, Lopez-Ayala, P, additional, Koechlin, L, additional, Boeddinghaus, J, additional, Nestelberger, T, additional, Okamura, B, additional, Muench-Gerber, T S, additional, Rubini Gimenez, M, additional, Miro, O, additional, Martin-Sanchez, F J, additional, Christ, M, additional, Keller, D, additional, Lindhal, B, additional, Giannitsis, E, additional, and Mueller, C, additional

Published
2023
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8. Absolutely continuous spectrum of Stark operators

Author

Christ, M. and Kiselev, A.

Subjects
Mathematics - Spectral Theory, Mathematical Physics, 34L40, 81Q10
Abstract

We prove several new results on the absolutely continuous spectra of perturbed one-dimensional Stark operators. First, we find new classes of perturbations, characterized mainly by smoothness conditions, which preserve purely absolutely continuous spectrum. Then we establish stability of the absolutely continuous spectrum in more general situations, where imbedded singular spectrum may occur. We present two kinds of optimal conditions for the stability of absolutely continuous spectrum: decay and smoothness. In the decay direction, we show that a sufficient (in the power scale) condition is $|q(x)| \leq C(1+|x|)^{-{1/4}-\epsilon};$ in the smoothness direction, a sufficient condition in H\"older classes is $q \in C^{{1/2}+\epsilon}(\reals)$. On the other hand, we show that there exist potentials which both satisfy $|q(x)| \leq C(1+|x|)^{-1/4}$ and belong to $C^{1/2}(\reals)$ for which the spectrum becomes purely singular on the whole real axis, so that the above results are optimal within the scales considered., Comment: 29 pages

Published
2001

9. Scattering and wave operators for one-dimensional Schr\'odinger operators with slowly decaying nonsmooth potentials

Author

Christ, M. and Kiselev, A.

Subjects
Mathematics - Spectral Theory, Mathematical Physics, 34L40, 35P25, 42B20, 81Q10
Abstract

We prove existence of modified wave operators for one-dimensional Schr\"odinger equations with potential in $L^p(\reals)$, $p<2$. If in addition the potential is conditionally integrable, then the usual M\"oller wave operators exist. We also prove asymptotic completeness of these wave operators for some classes of random potentials, and for almost every boundary condition for any given potential., Comment: 46 pages

Published
2001

10. External Validation of the SMART Medical Clearance Form for Emergency Patients With Psychiatric Manifestations.

Author

Festini, D., Wthrich, F., and Christ, M.

Abstract

Background: The SMART Medical Clearance Form, developed in the USA, is used to standardize the medical evaluation of emergency patients with primarily psychiatric manifestations. The goal of this study was external validation of the use of this form. Methods: Data were collected retrospectively on emergency patients with psychiatric manifestations. The combined primary clinical endpoint consisted of hospitalization, repeated presentation to the emergency room, and/or death within 30 days. Results: From September 2019 to June 2022, 2404 patients presented with psychiatric manifestations to the emergency room of the Cantonal Hospital of Lucerne, Switzerland, of whom 674 were included in the study. 134 did not satisfy any of the parameters of the SMART Medical Clearance Form (the nSMART group), while 540 satisfied at least one parameter (the pSMART group). In the nSMART group, there were no hospitalizations for a medical indication, no repeated presentations for medical reasons, and no deaths within 30 days. In the pSMART group, there were 90 hospitalizations, 4 repeated presentations, and 4 deaths within 30 days. Although 44% of the patients in the nSMART group underwent further diagnostic studies, such as imaging or laboratory tests, none of these studies led to any change in these patients further clinical management. Conclusion: Use of the SMART Medical Clearance Form apparently enables safe standardized processing of patients with psychiatric manifestations in the emergency room. [ABSTRACT FROM AUTHOR]

Published
2024
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11. GBDTMO: as new option for early-stage breast cancer detection and classification using machine learning.

Author

A. S., Vibith and Christ M C, Jobin

Subjects
MACHINE learning, BREAST cancer, TUMOR classification, EARLY detection of cancer, CANCER diagnosis, FEATURE selection
Abstract

Breast cancer is the second leading cause of disease death in women, after lung and bronchus cancer. According to measurements, mammography misses breast cancer in 10% to 15% of cases for women aged 50 to 69 years. In the current study, we used the Wisconsin breast cancer dataset to develop a two-stage model for breast cancer diagnosis. The main goal of this study effort is to effectively carry out feature selection and classification tasks. Gradient Boosting Decision Tree-based Mayfly Optimisation (GBDTMO), an innovative and efficient breast cancer diagnostic machine learning system, is provided. In the second stage, we employ a Mayfly search to determine which subset of traits is the best. Two more well-known datasets on breast cancer, the ICCR and the Cancer Corpus, were also compared for classification accuracy. The accuracy of the suggested GBDTMO model was higher than that of the existing GBDT and Practical Federated Gradient Boosting Decision Tree (PFGBDT), which had accuracy values of 93.25% and 94.25%, respectively. Similarly, the recall, F-measure, and ROC area values were 98.52%, 97.52%, and 96.32%, respectively. Furthermore, it demonstrated a lower RMSE of 0.98 than the existing GBDT and PFGBDT. [ABSTRACT FROM AUTHOR]

Published
2023
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12. On multilinear oscillatory integrals, nonsingular and singular

Author

Christ, M, Li, X C, Tao, T, and Thiele, C

Abstract

Basic questions concerning nonsingular multilinear operators with oscillatory factors are posed and partially answered. L-p norm inequalities are established for multilinear integral operators of Calderon-Zygmund type which incorporate oscillatory factors e(iP), where P is a real-valued polynomial.

Published
2005

13. GBDTMO: as new option for early-stage breast cancer detection and classification using machine learning

Author

Vibith, A. S., Jobin Christ, M. C., Vibith, A. S., and Jobin Christ, M. C.

Abstract

Breast cancer is the second leading cause of disease death in women, after lung and bronchus cancer. According to measurements, mammography misses breast cancer in 10% to 15% of cases for women aged 50 to 69 years. In the current study, we used the Wisconsin breast cancer dataset to develop a two-stage model for breast cancer diagnosis. The main goal of this study effort is to effectively carry out feature selection and classification tasks. Gradient Boosting Decision Tree-based Mayfly Optimisation (GBDTMO), an innovative and efficient breast cancer diagnostic machine learning system, is provided. In the second stage, we employ a Mayfly search to determine which subset of traits is the best. Two more well-known datasets on breast cancer, the ICCR and the Cancer Corpus, were also compared for classification accuracy. The accuracy of the suggested GBDTMO model was higher than that of the existing GBDT and Practical Federated Gradient Boosting Decision Tree (PFGBDT), which had accuracy values of 93.25% and 94.25%, respectively. Similarly, the recall, F-measure, and ROC area values were 98.52%, 97.52%, and 96.32%, respectively. Furthermore, it demonstrated a lower RMSE of 0.98 than the existing GBDT and PFGBDT.

Published
2023

14. 0/1h-algorithm using a new high-sensitivity cardiac troponin I assay for early diagnosis of myocardial infarction

Author

Koechlin, L, primary, Boeddinghaus, J, additional, Lopez-Ayala, P, additional, Nestelberger, T, additional, Wussler, D, additional, Twerenbold, R, additional, Zimmermann, T, additional, Wildi, K, additional, Miro, O, additional, Martin-Sanchez, J, additional, Keller, D, additional, Christ, M, additional, Buser, A, additional, Rubini Gimenez, M, additional, and Mueller, C, additional

Published
2022
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17. Performance of high-sensitivity cardiac troponin T versus I for the early diagnosis of myocardial infarction

Author

Koechlin, L, primary, Boeddinghaus, J, additional, Lopez-Ayala, P, additional, Nestelberger, T, additional, Miro, O, additional, Wussler, D, additional, Zimmermann, T, additional, Strebel, I, additional, Christ, M, additional, Wildi, K, additional, Rubini Gimenez, M, additional, Martin-Sanchez, J, additional, Keller, D, additional, Twerenbold, R, additional, and Mueller, C, additional

Published
2022
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18. Clinical risk scores versus simple integrated clinical judgment in patients with suspected acute coronary syndromes

Author

Boeddinghaus, J, primary, Meier, M, additional, Nestelberger, T, additional, Koechlin, L, additional, Lopez-Ayala, P, additional, Rubini Gimenez, M, additional, Miro, O, additional, Martin-Sanchez, J, additional, Kawecki, D, additional, Keller, D, additional, Nickel, C, additional, Bingisser, R, additional, Christ, M, additional, and Mueller, C, additional

Published
2022
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19. Extending the no objective testing rules to patients triaged by the ESC 0/1-hour algorithms

Author

Boeddinghaus, J, primary, Ratmann, P D, additional, Nestelberger, T, additional, Lopez-Ayala, P, additional, Koechlin, L, additional, Wildi, K, additional, Miro, O, additional, Martin-Sanchez, J, additional, Christ, M, additional, Gualandro, D, additional, Rubini Gimenez, M, additional, Keller, D, additional, Buser, A, additional, and Mueller, C, additional

Published
2022
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20. Cardiac arrest teams and time of day: effects on surviving in-hospital resuscitation

Author

Christ M, Dierschke W, von Auenmueller KI, van Bracht M, Grett M, and Trappe HJ

Subjects
Medicine (General), R5-920
Abstract

Martin Christ, Wolfgang Dierschke, Katharina Isabel von Auenmueller, Marc van Bracht, Martin Grett, Hans-Joachim Trappe Department of Cardiology and Angiology, Marienhospital Herne, Ruhr – University Bochum, Herne, Germany Objectives: Little is known about the factors that influence survival following in-hospital resuscitation, but previous investigations have suggested that in-hospital resuscitations outside of regular working hours are associated with worse survival rates. Material and methods: In-hospital cardiac arrest teams at our hospital were instructed to complete a questionnaire following every emergency call between July 2011 and June 2013. Data on all resuscitation attempts were collected and analyzed. Results: A total of 65 in-hospital resuscitations were recorded in 42 males (64.6%) and 23 females (35.4%) (mean age 72.0±14.3 years). A total of 54 (83.1%) cardiac arrests were witnessed; seven (10.8%) showed a shockable rhythm at the time of the first ECG. Resuscitation attempts lasted 29.3±41.3 minutes, and 4.1±3.1 mg epinephrine was given. Return of spontaneous circulation could be achieved in 38 patients (58.5%); 29 (44.6%) survived the first day, 23 (35.4%) the seventh day, and 15 patients (23.1%) were discharged alive. Significantly more in-hospital resuscitations were obtained for those performed during non-regular working hours (P

Published
2014

24. Epidemiology, treatment and outcome of patients with lower respiratory tract infection presenting to emergency departments with dyspnoea (AANZDEM and EuroDEM studies).

Author

Golea A., Garcia-Castrillo L., Laribi S., Kelly A.-M., Body R., Kuan W.S., Harjola V.-P., Jones P., Verschuren F., Holdgate A., Christ M., Graham C.A., Barletta C., Capsec J., Rousseau G., Keijzers G., van Meer O., Craig S., Karamercan M., Klim S., Golea A., Garcia-Castrillo L., Laribi S., Kelly A.-M., Body R., Kuan W.S., Harjola V.-P., Jones P., Verschuren F., Holdgate A., Christ M., Graham C.A., Barletta C., Capsec J., Rousseau G., Keijzers G., van Meer O., Craig S., Karamercan M., and Klim S.

Abstract

Objective: Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania/South-East Asia (SEA) cohorts. Method(s): We conducted a prospective cohort study with three time points in Europe and Oceania/SEA. We included in this manuscript patients presenting to EDs with dyspnoea and a diagnosis of LRTI in ED. We collected comorbidities, chronic medication, clinical signs at arrival, laboratory parameters, ED management and patient outcomes. Result(s): A total of 1389 patients were included, 773 in Europe and 616 in SEA. The European cohort had more comorbidities including chronic heart failure, obesity, chronic obstructive pulmonary disease and smoking. Levels of inflammatory markers were higher in Europe. There were more patients with inflammatory markers in Europe and more hypercapnia in Oceania/SEA. The use of antibiotics was higher in SEA (72.2% vs 61.8%, P < 0.001) whereas intravenous diuretics, non-invasive and invasive ventilation were higher in Europe. Intensive care unit admission rate was 9.9% in Europe cohort and 3.4% in Oceania/SEA cohort. ED mortality was 1% and overall in-hospital mortality was 8.7% with no differences between regions. Conclusion(s): More patients with LRTI in Europe presented with cardio-respiratory comorbidities, they received more adjunct therapies and had a higher intensive care unit admission rate than patients from Oceania/SEA, although mortality was similar between the two cohorts.Copyright © 2020 Australasian College for Emergency Medicine

Published
2021

25. Early standardized clinical judgement for syncope diagnosis in the emergency department

Author

du Fay de Lavallaz, J., Badertscher, P., Zimmermann, T., Nestelberger, T., Walter, J., Strebel, I., Coelho, C., Miró, Salgado, E., Christ, M., Geigy, N., Cullen, L., Than, M., Javier Martin-Sanchez, F., Di Somma, S., Frank Peacock, W., Morawiec, B., Wussler, D., Keller, D. I., Gualandro, D., Michou, E., Kühne, M., Lohrmann, J., Reichlin, T., Mueller, C., Flores, Dayana, Widmer, Velina, Breidthardt, Tobias, Bustamante Mandrión, José, Poepping, Imke, Kawecki, Damian, Muzyk, Piotr, Belkin, Maria, Puelacher, Christian, Lopez Ayala, Pedro, Freese, Michael, Boeddinghaus, Jasper, Diebold, Matthias, Koechlin, Luca, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Campodarve, Isabel, Gea, Joachim, Cruz, Helena Mañé, Calderon, Sofìa, Fuenzalida Inostroza, Carolina Isabel, Briñón, Miguel Angel García, Suárez Cadenas, María, Bingisser, Roland, Osswald, Stefan, other, and, du Fay de Lavallaz, J., Badertscher, P., Zimmermann, T., Nestelberger, T., Walter, J., Strebel, I., Coelho, C., Miró, Salgado, E., Christ, M., Geigy, N., Cullen, L., Than, M., Javier Martin-Sanchez, F., Di Somma, S., Frank Peacock, W., Morawiec, B., Wussler, D., Keller, D. I., Gualandro, D., Michou, E., Kühne, M., Lohrmann, J., Reichlin, T., Mueller, C., Flores, Dayana, Widmer, Velina, Breidthardt, Tobias, Bustamante Mandrión, José, Poepping, Imke, Kawecki, Damian, Muzyk, Piotr, Belkin, Maria, Puelacher, Christian, Lopez Ayala, Pedro, Freese, Michael, Boeddinghaus, Jasper, Diebold, Matthias, Koechlin, Luca, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Campodarve, Isabel, Gea, Joachim, Cruz, Helena Mañé, Calderon, Sofìa, Fuenzalida Inostroza, Carolina Isabel, Briñón, Miguel Angel García, Suárez Cadenas, María, Bingisser, Roland, Osswald, Stefan, and other, and

Abstract

Background: The diagnosis of cardiac syncope remains a challenge in the emergency department (ED). Objective: Assessing the diagnostic accuracy of the early standardized clinical judgement (ESCJ) including a standardized syncope-specific case report form (CRF) in comparison with a recommended multivariable diagnostic score. Methods: In a prospective international observational multicentre study, diagnostic accuracy for cardiac syncope of ESCJ by the ED physician amongst patients ≥ 40 years presenting with syncope to the ED was directly compared with that of the Evaluation of Guidelines in Syncope Study (EGSYS) diagnostic score. Cardiac syncope was centrally adjudicated independently of the ESCJ or conducted workup by two ED specialists based on all information available up to 1-year follow-up. Secondary aims included direct comparison with high-sensitivity cardiac troponin I (hs-cTnI) and B-type natriuretic peptide (BNP) concentrations and a Lasso regression to identify variables contributing most to ESCJ. Results: Cardiac syncope was adjudicated in 252/1494 patients (15.2%). The diagnostic accuracy of ESCJ for cardiac syncope as quantified by the area under the curve (AUC) was 0.87 (95% CI: 0.84–0.89), and higher compared with the EGSYS diagnostic score (0.73 (95% CI: 0.70–0.76)), hs-cTnI (0.77 (95% CI: 0.73–0.80)) and BNP (0.77 (95% CI: 0.74–0.80)), all P < 0.001. Both biomarkers (alone or in combination) on top of the ESCJ significantly improved diagnostic accuracy. Conclusion: ESCJ including a standardized syncope-specific CRF has very high diagnostic accuracy and outperforms the EGSYS score, hs-cTnI and BNP.

Published
2021

26. Epidemiology, treatment and outcome of patients with lower respiratory tract infection presenting to emergency departments with dyspnoea (AANZDEMandEuroDEMstudies)

Author

Rousseau, G, Keijzers, G, van Meer, O, Craig, S, Karamercan, M, Klim, S, Body, R, Kuan, WS, Harjola, V-P, Jones, P, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Capsec, J, Barletta, C, Graham, CA, Garcia-Castrillo, L, Laribi, S, Kelly, A-M, Rousseau, G, Keijzers, G, van Meer, O, Craig, S, Karamercan, M, Klim, S, Body, R, Kuan, WS, Harjola, V-P, Jones, P, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Capsec, J, Barletta, C, Graham, CA, Garcia-Castrillo, L, Laribi, S, and Kelly, A-M

Abstract

OBJECTIVE: Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania/South-East Asia (SEA) cohorts. METHODS: We conducted a prospective cohort study with three time points in Europe and Oceania/SEA. We included in this manuscript patients presenting to EDs with dyspnoea and a diagnosis of LRTI in ED. We collected comorbidities, chronic medication, clinical signs at arrival, laboratory parameters, ED management and patient outcomes. RESULTS: A total of 1389 patients were included, 773 in Europe and 616 in SEA. The European cohort had more comorbidities including chronic heart failure, obesity, chronic obstructive pulmonary disease and smoking. Levels of inflammatory markers were higher in Europe. There were more patients with inflammatory markers in Europe and more hypercapnia in Oceania/SEA. The use of antibiotics was higher in SEA (72.2% vs 61.8%, P < 0.001) whereas intravenous diuretics, non-invasive and invasive ventilation were higher in Europe. Intensive care unit admission rate was 9.9% in Europe cohort and 3.4% in Oceania/SEA cohort. ED mortality was 1% and overall in-hospital mortality was 8.7% with no differences between regions. CONCLUSIONS: More patients with LRTI in Europe presented with cardio-respiratory comorbidities, they received more adjunct therapies and had a higher intensive care unit admission rate than patients from Oceania/SEA, although mortality was similar between the two cohorts.

Published
2021

30. Erratum to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC‐GLOSSARI): a multicenter, multinational, 14-day inception cohort study (Intensive Care Medicine, (2016), 42, 5, (953), 10.1007/s00134-016-4317-4)

Author

Auer J., Auer, J, Schatzl, G, Mach, K, Gruber, H, Schreurs, E, Vander Laenen, M, Ceunen, H, Wauters, J, Francois, G, Deschamps, P, Castanares, D, Debels, D, Pierrakos, C, Vincent, J, Taccone, F, Vymazal, T, Gornik, I, Vujiaklija Brajkovic, A, Medici, R, Nielsen, J, Bendtsen, A, Siegel, H, Suonsyrja, T, Hraech, S, Chiche, J, Daviaux, F, Guillot, M, Castelain, V, Losser, R, Novy, E, Timsit, J, Bouadma, L, Misset, B, Philippart, F, Mallat, J, Zogheib, E, Miclo, M, Teboul, J, Anguel, N, Darmon, M, Pham, T, Barberet, G, Plantefeve, G, Floccard, B, Kheladze, Z, Reinhart, K, Sakr, Y, Bloos, F, Faltlhauser, A, Helmes, T, Zacharowski, K, Meybohm, P, Schwarzkopf, K, Christ, M, Baumgaertel, M, John, S, Nentwich, J, Deja, M, Goldmann, A, Gottschalk, A, Honig, F, Siepe, B, Goebel, U, Lehmke, J, Behrens, S, Fiedler, K, Sagoschen, I, Riessen, R, Haap, M, Simon, P, Kaisers, U, Niesen, M, Jaschinski, U, Hoersch, S, Jung, A, Allgaeuer, S, Haake, H, Lange, A, Papanikolaou, M, Balla, M, Giannakou, M, Soultati, I, Nikos, G, Koulouras, V, Kyriazopoulos, G, Gkika, D, Vlachogianni, G, Psaroulis, K, Mouloudi, E, Massa, E, Nichol, A, Meany, E, Motherway, C, Bellani, G, Pota, V, Schiavone, V, Girardis, M, Busani, S, Petrucci, N, Di Pasquale, R, Mazzini, P, Molin, A, Pellerano, G, Volta, C, Spadaro, S, Guarracino, F, Savioli, M, Pellis, T, Chinellato, N, Gatta, A, Cecchini, F, Raineri, S, Cortegiani, A, Kekstas, G, Karosas, V, Anguseva, T, Mitrev, Z, Beck, O, Cimic, N, Janssen, G, Bormans, L, Kuiper, M, Koopmans, K, Den Boer, S, de Groot, M, Dennesen, P, van den Bosch, J, Kluge, G, Mikaszewska-Sokolewicz, M, Lazowski, T, Chruscikowski, M, Machon, J, Adamik, B, Kubler, A, Wieczorek, A, Afonso, S, Matos, R, Catorze, N, Araujo, A, Costa, Z, Pais-de-Lacerda, A, Martins, I, Cardiga, R, Fernandes, L, Serra, I, Martinho, A, Tomescu, D, Popescu, M, Scarlatescu, E, Stoica, R, Macri, A, Filipescu, D, Rupnik, E, Tomic, V, Sifrer, F, Sole Violan, J, Ferrer Aguero, J, Izura, B, Monedero, P, Munos de Cabo, C, Aguilar, G, Belda, F, Blanquer, J, Nives Carbonell, E, Lopez-Delgado, J, Aragon, C, Joya, C, Ortiz-Leyba, C, Fernandez Gonzalez, C, de la Torre-Prados, M, Puerto-Morlan, A, Araujo Aguilar, P, Tomas Marsilla, J, Vera Aratcoz, P, Olmo, A, Ferrer Roca, R, Catalan, R, Garcia Olivares, P, Albis, A, Alvarez, M, Corcoles Gonzalez, V, Gutierrez Rubio, J, Montoiro Allue, R, Rubio Mateo-Sidron, J, Hobrok, M, Cecconi, M, Di Tomasso, N, Raj, A, Szakmany, T, Srinivasa, L, Mathew, S, Ferguson, A, Blahut-Zugaj, M, Watters, M, Henderson, S, Sim, M, Csabi, P, O'Neill, O, Nutt, C, Humphreys, S, Bhowmick, K, Donnelly, A, O'Kane, S, Garfield, M, Jha, R, Unni, N, Gordon, A, Rubulotta, F, Ravi, K, Lunch, G, Franco, F, Higgs, D, Strandvik, G, Jonas, A, Hopkins, P, Hurst, T, Bellini, A, Balogun, O, Srinivasan, R, Ostermann, M, Alexander, P, Mccalman, K, Bedford, J, Fulop, M, Brescia, G, Strachan, J, Meyer, J, Stotz, M, Brett, S, Zand, F, Nikandish, R, Hashemian, S, Jamaati, H, Alsheikhly, A, Almekhlafi, G, Albarrak, M, Maghrabi, A, Salahuddin, N, Aisa, T, Atalan, H, Sungur, M, Hegazi, M, Bauer, P, Mukkera, S, Fried, J, Barger, M, Gueret, R, Gonzalez, C, Lovesio, C, Dellera, C, Barrios, D, Leite Mendes, C, Gottardo, P, Caser, E, Santos, C, Carvalho, A, Teixeira, C, Samaniego, W, Whittle, S, Molano, D, Rojas, A, Guerra, K, Villamagua, B, Salgado-Yepez, E, Morocho, D, Remache-Vargas, N, Namendys-Silva, S, Rodriguez, D, Dominguez, G, Barraza, G, Bermudez-Aceves, E, Sanchez-Hurtado, L, Baltazar-Torres, J, Quispe Sierra, R, Chavez, C, von Osten, I, Van Haren, C, Smalley, N, Kol, M, Wong, H, Smith, R, Yu, L, Wu, X, Chao, L, Zhai, Q, Wu, D, Zhang, X, Jing, X, Bigornia, R, Ikeda-Maquiling, Y, Robles, J, Palo, J, Nguyen, T, Dao, C, Dixit, S, Gurjar, M, Reddy, P, Pravin, A, Simran, S, Ramakrishnan, N, Shetty, R, Udwadia, F, Faraz, M, Indraratna, K, Rajasinhe, J, Auer J., Schatzl G., Mach K., Gruber H., Schreurs E., Vander Laenen M., Ceunen H., Wauters J., Francois G., Deschamps P., Castanares D., Debels D., Pierrakos C., Vincent J. L., Taccone F., Vymazal T., Gornik I., Vujiaklija Brajkovic A., Medici R., Nielsen J., Bendtsen A., Siegel H., Suonsyrja T., Hraech S., Chiche J. -D., Daviaux F., Guillot M., Castelain V., Losser R. -R., Novy E., Timsit J. -F., Bouadma L., Misset B., Philippart F., Mallat J., Zogheib E., Miclo M., Teboul J. -L., Anguel N., Darmon M., Pham T., Barberet G., Plantefeve G., Floccard B., Kheladze Z., Reinhart K., Sakr Y., Bloos F., Faltlhauser A., Helmes T., Zacharowski K., Meybohm P., Schwarzkopf K., Christ M., Baumgaertel M., John S., Nentwich J., Deja M., Goldmann A., Gottschalk A., Honig F., Siepe B., Goebel U., Lehmke J., Behrens S., Fiedler K., Sagoschen I., Riessen R., Haap M., Simon P., Kaisers U., Niesen M., Jaschinski U., Hoersch S., Jung A., Allgaeuer S., Haake H., Lange A., Papanikolaou M., Balla M., Giannakou M., Soultati I., Nikos G., Koulouras V., Kyriazopoulos G., Gkika D., Vlachogianni G., Psaroulis K., Mouloudi E., Massa E., Nichol A., Meany E., Motherway C., Bellani G., Pota V., Schiavone V., Girardis M., Busani S., Petrucci N., Di Pasquale R., Mazzini P., Molin A., Pellerano G., Volta C., Spadaro S., Guarracino F., Savioli M., Pellis T., Chinellato N., Gatta A., Cecchini F., Raineri S. M., Cortegiani A., Kekstas G., Karosas V., Anguseva T., Mitrev Z., Beck O., Cimic N., Janssen G., Bormans L., Kuiper M., Koopmans K., Den Boer S., de Groot M., Dennesen P., van den Bosch J., Kluge G., Mikaszewska-Sokolewicz M., Lazowski T., Chruscikowski M., Machon J., Adamik B., Kubler A., Wieczorek A., Afonso S., Matos R., Catorze N., Araujo A., Costa Z., Pais-de-Lacerda A., Martins I., Cardiga R., Fernandes L., Serra I., Martinho A., Tomescu D., Popescu M., Scarlatescu E., Stoica R., Macri A., Filipescu D., Rupnik E., Tomic V., Sifrer F., Sole Violan J., Ferrer Aguero J. M., Izura B. J., Monedero P., Munos de Cabo C., Aguilar G., Belda F. J., Blanquer J., Nives Carbonell E., Lopez-Delgado J. -C., Aragon C., Joya C., Ortiz-Leyba C., Fernandez Gonzalez C. J., de la Torre-Prados M. -V., Puerto-Morlan A., Araujo Aguilar P., Tomas Marsilla J. I., Vera Aratcoz P., Olmo A., Ferrer Roca R., Catalan R. M., Garcia Olivares P., Albis A., Alvarez M., Corcoles Gonzalez V., Gutierrez Rubio J. M., Montoiro Allue R., Rubio Mateo-Sidron J., Hobrok M., Cecconi M., Di Tomasso N., Raj A., Szakmany T., Srinivasa L., Mathew S., Ferguson A., Blahut-Zugaj M., Watters M., Henderson S., Sim M., Csabi P., O'Neill O., Nutt C., Humphreys S., Bhowmick K., Donnelly A., O'Kane S., Garfield M., Jha R., Unni N., Gordon A., Rubulotta F., Ravi K., Lunch G., Franco F., Higgs D., Strandvik G., Jonas A., Hopkins P., Hurst T., Bellini A., Balogun O., Srinivasan R., Ostermann M., Alexander P., McCalman K., Bedford J., Fulop M., Brescia G., Strachan J., Meyer J., Stotz M., Brett S., Zand F., Nikandish R., Hashemian S., Jamaati H., Alsheikhly A. S., Almekhlafi G., Albarrak M., Maghrabi A., Salahuddin N., Aisa T., Atalan H. K., Sungur M., Hegazi M., Bauer P., Mukkera S., Fried J., Barger M., Gueret R., Gonzalez C., Lovesio C., Dellera C., Barrios D., Leite Mendes C., Gottardo P., Caser E., Santos C., Carvalho A., Teixeira C., Samaniego W., Whittle S., Molano D., Rojas A., Guerra K., Villamagua B., Salgado-Yepez E., Morocho D., Remache-Vargas N., Namendys-Silva S., Rodriguez D., Dominguez G., Barraza G., Bermudez-Aceves E., Sanchez-Hurtado L. A., Baltazar-Torres J. A., Quispe Sierra R., Chavez C., von Osten I., Van Haren C., Smalley N., Kol M., Wong H., Smith R., Yu L., Wu X., Chao L., Zhai Q., Wu D., Zhang X., Jing X., Bigornia R., Ikeda-Maquiling Y., Robles J., Palo J. E., Nguyen T., Dao C., Dixit S., Gurjar M., Reddy P., Pravin A., Simran S., Ramakrishnan N., Shetty R., Udwadia F., Faraz M., Indraratna K., Rajasinhe J., Auer J., Auer, J, Schatzl, G, Mach, K, Gruber, H, Schreurs, E, Vander Laenen, M, Ceunen, H, Wauters, J, Francois, G, Deschamps, P, Castanares, D, Debels, D, Pierrakos, C, Vincent, J, Taccone, F, Vymazal, T, Gornik, I, Vujiaklija Brajkovic, A, Medici, R, Nielsen, J, Bendtsen, A, Siegel, H, Suonsyrja, T, Hraech, S, Chiche, J, Daviaux, F, Guillot, M, Castelain, V, Losser, R, Novy, E, Timsit, J, Bouadma, L, Misset, B, Philippart, F, Mallat, J, Zogheib, E, Miclo, M, Teboul, J, Anguel, N, Darmon, M, Pham, T, Barberet, G, Plantefeve, G, Floccard, B, Kheladze, Z, Reinhart, K, Sakr, Y, Bloos, F, Faltlhauser, A, Helmes, T, Zacharowski, K, Meybohm, P, Schwarzkopf, K, Christ, M, Baumgaertel, M, John, S, Nentwich, J, Deja, M, Goldmann, A, Gottschalk, A, Honig, F, Siepe, B, Goebel, U, Lehmke, J, Behrens, S, Fiedler, K, Sagoschen, I, Riessen, R, Haap, M, Simon, P, Kaisers, U, Niesen, M, Jaschinski, U, Hoersch, S, Jung, A, Allgaeuer, S, Haake, H, Lange, A, Papanikolaou, M, Balla, M, Giannakou, M, Soultati, I, Nikos, G, Koulouras, V, Kyriazopoulos, G, Gkika, D, Vlachogianni, G, Psaroulis, K, Mouloudi, E, Massa, E, Nichol, A, Meany, E, Motherway, C, Bellani, G, Pota, V, Schiavone, V, Girardis, M, Busani, S, Petrucci, N, Di Pasquale, R, Mazzini, P, Molin, A, Pellerano, G, Volta, C, Spadaro, S, Guarracino, F, Savioli, M, Pellis, T, Chinellato, N, Gatta, A, Cecchini, F, Raineri, S, Cortegiani, A, Kekstas, G, Karosas, V, Anguseva, T, Mitrev, Z, Beck, O, Cimic, N, Janssen, G, Bormans, L, Kuiper, M, Koopmans, K, Den Boer, S, de Groot, M, Dennesen, P, van den Bosch, J, Kluge, G, Mikaszewska-Sokolewicz, M, Lazowski, T, Chruscikowski, M, Machon, J, Adamik, B, Kubler, A, Wieczorek, A, Afonso, S, Matos, R, Catorze, N, Araujo, A, Costa, Z, Pais-de-Lacerda, A, Martins, I, Cardiga, R, Fernandes, L, Serra, I, Martinho, A, Tomescu, D, Popescu, M, Scarlatescu, E, Stoica, R, Macri, A, Filipescu, D, Rupnik, E, Tomic, V, Sifrer, F, Sole Violan, J, Ferrer Aguero, J, Izura, B, Monedero, P, Munos de Cabo, C, Aguilar, G, Belda, F, Blanquer, J, Nives Carbonell, E, Lopez-Delgado, J, Aragon, C, Joya, C, Ortiz-Leyba, C, Fernandez Gonzalez, C, de la Torre-Prados, M, Puerto-Morlan, A, Araujo Aguilar, P, Tomas Marsilla, J, Vera Aratcoz, P, Olmo, A, Ferrer Roca, R, Catalan, R, Garcia Olivares, P, Albis, A, Alvarez, M, Corcoles Gonzalez, V, Gutierrez Rubio, J, Montoiro Allue, R, Rubio Mateo-Sidron, J, Hobrok, M, Cecconi, M, Di Tomasso, N, Raj, A, Szakmany, T, Srinivasa, L, Mathew, S, Ferguson, A, Blahut-Zugaj, M, Watters, M, Henderson, S, Sim, M, Csabi, P, O'Neill, O, Nutt, C, Humphreys, S, Bhowmick, K, Donnelly, A, O'Kane, S, Garfield, M, Jha, R, Unni, N, Gordon, A, Rubulotta, F, Ravi, K, Lunch, G, Franco, F, Higgs, D, Strandvik, G, Jonas, A, Hopkins, P, Hurst, T, Bellini, A, Balogun, O, Srinivasan, R, Ostermann, M, Alexander, P, Mccalman, K, Bedford, J, Fulop, M, Brescia, G, Strachan, J, Meyer, J, Stotz, M, Brett, S, Zand, F, Nikandish, R, Hashemian, S, Jamaati, H, Alsheikhly, A, Almekhlafi, G, Albarrak, M, Maghrabi, A, Salahuddin, N, Aisa, T, Atalan, H, Sungur, M, Hegazi, M, Bauer, P, Mukkera, S, Fried, J, Barger, M, Gueret, R, Gonzalez, C, Lovesio, C, Dellera, C, Barrios, D, Leite Mendes, C, Gottardo, P, Caser, E, Santos, C, Carvalho, A, Teixeira, C, Samaniego, W, Whittle, S, Molano, D, Rojas, A, Guerra, K, Villamagua, B, Salgado-Yepez, E, Morocho, D, Remache-Vargas, N, Namendys-Silva, S, Rodriguez, D, Dominguez, G, Barraza, G, Bermudez-Aceves, E, Sanchez-Hurtado, L, Baltazar-Torres, J, Quispe Sierra, R, Chavez, C, von Osten, I, Van Haren, C, Smalley, N, Kol, M, Wong, H, Smith, R, Yu, L, Wu, X, Chao, L, Zhai, Q, Wu, D, Zhang, X, Jing, X, Bigornia, R, Ikeda-Maquiling, Y, Robles, J, Palo, J, Nguyen, T, Dao, C, Dixit, S, Gurjar, M, Reddy, P, Pravin, A, Simran, S, Ramakrishnan, N, Shetty, R, Udwadia, F, Faraz, M, Indraratna, K, Rajasinhe, J, Auer J., Schatzl G., Mach K., Gruber H., Schreurs E., Vander Laenen M., Ceunen H., Wauters J., Francois G., Deschamps P., Castanares D., Debels D., Pierrakos C., Vincent J. L., Taccone F., Vymazal T., Gornik I., Vujiaklija Brajkovic A., Medici R., Nielsen J., Bendtsen A., Siegel H., Suonsyrja T., Hraech S., Chiche J. -D., Daviaux F., Guillot M., Castelain V., Losser R. -R., Novy E., Timsit J. -F., Bouadma L., Misset B., Philippart F., Mallat J., Zogheib E., Miclo M., Teboul J. -L., Anguel N., Darmon M., Pham T., Barberet G., Plantefeve G., Floccard B., Kheladze Z., Reinhart K., Sakr Y., Bloos F., Faltlhauser A., Helmes T., Zacharowski K., Meybohm P., Schwarzkopf K., Christ M., Baumgaertel M., John S., Nentwich J., Deja M., Goldmann A., Gottschalk A., Honig F., Siepe B., Goebel U., Lehmke J., Behrens S., Fiedler K., Sagoschen I., Riessen R., Haap M., Simon P., Kaisers U., Niesen M., Jaschinski U., Hoersch S., Jung A., Allgaeuer S., Haake H., Lange A., Papanikolaou M., Balla M., Giannakou M., Soultati I., Nikos G., Koulouras V., Kyriazopoulos G., Gkika D., Vlachogianni G., Psaroulis K., Mouloudi E., Massa E., Nichol A., Meany E., Motherway C., Bellani G., Pota V., Schiavone V., Girardis M., Busani S., Petrucci N., Di Pasquale R., Mazzini P., Molin A., Pellerano G., Volta C., Spadaro S., Guarracino F., Savioli M., Pellis T., Chinellato N., Gatta A., Cecchini F., Raineri S. M., Cortegiani A., Kekstas G., Karosas V., Anguseva T., Mitrev Z., Beck O., Cimic N., Janssen G., Bormans L., Kuiper M., Koopmans K., Den Boer S., de Groot M., Dennesen P., van den Bosch J., Kluge G., Mikaszewska-Sokolewicz M., Lazowski T., Chruscikowski M., Machon J., Adamik B., Kubler A., Wieczorek A., Afonso S., Matos R., Catorze N., Araujo A., Costa Z., Pais-de-Lacerda A., Martins I., Cardiga R., Fernandes L., Serra I., Martinho A., Tomescu D., Popescu M., Scarlatescu E., Stoica R., Macri A., Filipescu D., Rupnik E., Tomic V., Sifrer F., Sole Violan J., Ferrer Aguero J. M., Izura B. J., Monedero P., Munos de Cabo C., Aguilar G., Belda F. J., Blanquer J., Nives Carbonell E., Lopez-Delgado J. -C., Aragon C., Joya C., Ortiz-Leyba C., Fernandez Gonzalez C. J., de la Torre-Prados M. -V., Puerto-Morlan A., Araujo Aguilar P., Tomas Marsilla J. I., Vera Aratcoz P., Olmo A., Ferrer Roca R., Catalan R. M., Garcia Olivares P., Albis A., Alvarez M., Corcoles Gonzalez V., Gutierrez Rubio J. M., Montoiro Allue R., Rubio Mateo-Sidron J., Hobrok M., Cecconi M., Di Tomasso N., Raj A., Szakmany T., Srinivasa L., Mathew S., Ferguson A., Blahut-Zugaj M., Watters M., Henderson S., Sim M., Csabi P., O'Neill O., Nutt C., Humphreys S., Bhowmick K., Donnelly A., O'Kane S., Garfield M., Jha R., Unni N., Gordon A., Rubulotta F., Ravi K., Lunch G., Franco F., Higgs D., Strandvik G., Jonas A., Hopkins P., Hurst T., Bellini A., Balogun O., Srinivasan R., Ostermann M., Alexander P., McCalman K., Bedford J., Fulop M., Brescia G., Strachan J., Meyer J., Stotz M., Brett S., Zand F., Nikandish R., Hashemian S., Jamaati H., Alsheikhly A. S., Almekhlafi G., Albarrak M., Maghrabi A., Salahuddin N., Aisa T., Atalan H. K., Sungur M., Hegazi M., Bauer P., Mukkera S., Fried J., Barger M., Gueret R., Gonzalez C., Lovesio C., Dellera C., Barrios D., Leite Mendes C., Gottardo P., Caser E., Santos C., Carvalho A., Teixeira C., Samaniego W., Whittle S., Molano D., Rojas A., Guerra K., Villamagua B., Salgado-Yepez E., Morocho D., Remache-Vargas N., Namendys-Silva S., Rodriguez D., Dominguez G., Barraza G., Bermudez-Aceves E., Sanchez-Hurtado L. A., Baltazar-Torres J. A., Quispe Sierra R., Chavez C., von Osten I., Van Haren C., Smalley N., Kol M., Wong H., Smith R., Yu L., Wu X., Chao L., Zhai Q., Wu D., Zhang X., Jing X., Bigornia R., Ikeda-Maquiling Y., Robles J., Palo J. E., Nguyen T., Dao C., Dixit S., Gurjar M., Reddy P., Pravin A., Simran S., Ramakrishnan N., Shetty R., Udwadia F., Faraz M., Indraratna K., and Rajasinhe J.

Abstract

In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to list the members of the groups here: (Table presented.).

Published
2018

31. Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicentre single-arm clinical trial

Author

Schmidtmann, I. (Irene), Ageno, W. (Walter), Bauersachs, R.M. (Rupert M.), Becattini, C. (Cecilia), Bernardi, E. (Enrico), Beyer-Westendorf, J. (Jan), Bonacchini, L. (Luca), Brachmann, J. (Johannes), Christ, M. (Michael), Czihal, M. (Michael), Duerschmied, D. (Daniel), Empen, K. (Klaus), Espinola-Klein, C. (Christine), Ficker, J.H. (Joachim H.), Fonseca, C. (Candida), Genth-Zotz, S. (Sabine), Jiménez, D. (David), Harjola, V.P. (Veli-Pekka), Held, M. (Matthias), Iogna-Prat, L. (Lorenzo), Lange, T.J. (Tobias J.), Manolis, A. (Athanasios), Meyer, A. (Andreas), Mustonen, P. (Pirjo), Rauch-Kroehnert, U. (Ursula), Ruiz-Artacho, P. (Pedro), Schellong, S. (Sebastian), Schwaiblmair, M. (Martin), Stahrenberg, R. (Raoul), Westerweel, P.E. (Peter), Wild, P.S. (Philipp S.), Konstantinides, S.V. (Stavros V.), and Lankeit, M. (Mareike)

Subjects
Rivaroxaban, Pulmonary embolism, Home treatment, Management trial, Right ventricular dysfunction, Risk stratification
Abstract

Aims To investigate the efficacy and safety of early transition from hospital to ambulatory treatment in low-risk acute PE, using the oral factor Xa inhibitor rivaroxaban. Methods and results We conducted a prospective multicentre single-arm investigator initiated and academically sponsored management trial in patients with acute low-risk PE (EudraCT Identifier 2013-001657-28). Eligibility criteria included absence of (i) haemodynamic instability, (ii) right ventricular dysfunction or intracardiac thrombi, and (iii) serious comorbidities. Up to two nights of hospital stay were permitted. Rivaroxaban was given at the approved dose for PE for >_3 months. The primary outcome was symptomatic recurrent venous thromboembolism (VTE) or PE-related death within 3 months of enrolment. An interim analysis was planned after the first 525 patients, with prespecified early termination of the study if the null hypothesis could be rejected at the level of a = 0.004 (

Published
2020

32. Get with the guidelines: management of chronic obstructive pulmonary disease in emergency departments in Europe and Australasia is sub-optimal.

Author

Furyk J., Stuart P., Bament J., Brown M., Greven-Garcia R., Scott M., Cheri T., Nguyen M., Wong C.-P., Wong T.W., Leung L.-P., Man C.K., Bryant M., MacDonald S., Lee T., Mahlangu M., Mountain D., Rogers I., Otto T., Saiboon I.M., Rahman N.H., Lee W.Y., Lee F.C.Y., Russell S., Lawoko C., Laribi S., Al Dandachi G., Maignan M., Hermand D., Tessier C., Roy P.-M., Bucco L., Carbone G., Cosentini R., Truta S., Hrihorisan N., Cimpoesu D., Rotaru L., Petrica A., Cojocaru M., Nica S., Tudoran R., Vecerdi C., Puticiu M., Schonberger T., Coolsma C., Baggelaar M., Fransen N., van den Brand C., Idzenga D., Maas M., Franssen M., Mackaij-Staal C., Schutte L., de Kubber M., Mignot-Evers L., Penninga-Puister U., Jansen J., Kuijten J., Bouwhuis M., Reuben A., Smith J., Ramlakhan S., Darwent M., Gagg J., Keating L., Bongale S., Hardy E., Keep J., Jarman H., Crane S., Lawal O., Hassan T., Corfield A., Reed M., Smolarsky Y., Blaschke S., Jerrentrup C., Hohenstein C., Brunnler F., Ghuysen A., Vranckx M., Ergin M., Dundar Z.D., Altuncu Y.A., Arziman I., Avcil M., Katirci Y., Kokkonen L., Valli J., Kiljunen M., Tolonen J., Kaye S., Makela J., Metsaniitty J., Vaula E., Duytsche N., Garmilla P., Kelly A.-M., Van Meer O., Keijzers G., Motiejunaite J., Jones P., Body R., Craig S., Karamercan M., Klim S., Harjola V.-P., Verschuren F., Holdgate A., Christ M., Golea A., Graham C.A., Capsec J., Barletta C., Garcia-Castrillo L., Kuan W.S., McNulty R., Tan C., Cowell D.L., Jain N., Devillecourt T., Forrester A., Lee K., Chalkley D., Gillett M., Lozzi L., Asha S., Duffy M., Watkins G., Stone R., Rosengren D., Thone J., Martin S., Orda U., Thom O., Kinnear F., Eley R., Ryan A., Morel D., May C., Thomson G., Smith S., Smith R., Maclean A., Grummisch M., Meyer A., Meek R., Rosengarten P., Chan B., Haythorne H., Archer P., Wilson K., Knott J., Ritchie P., Furyk J., Stuart P., Bament J., Brown M., Greven-Garcia R., Scott M., Cheri T., Nguyen M., Wong C.-P., Wong T.W., Leung L.-P., Man C.K., Bryant M., MacDonald S., Lee T., Mahlangu M., Mountain D., Rogers I., Otto T., Saiboon I.M., Rahman N.H., Lee W.Y., Lee F.C.Y., Russell S., Lawoko C., Laribi S., Al Dandachi G., Maignan M., Hermand D., Tessier C., Roy P.-M., Bucco L., Carbone G., Cosentini R., Truta S., Hrihorisan N., Cimpoesu D., Rotaru L., Petrica A., Cojocaru M., Nica S., Tudoran R., Vecerdi C., Puticiu M., Schonberger T., Coolsma C., Baggelaar M., Fransen N., van den Brand C., Idzenga D., Maas M., Franssen M., Mackaij-Staal C., Schutte L., de Kubber M., Mignot-Evers L., Penninga-Puister U., Jansen J., Kuijten J., Bouwhuis M., Reuben A., Smith J., Ramlakhan S., Darwent M., Gagg J., Keating L., Bongale S., Hardy E., Keep J., Jarman H., Crane S., Lawal O., Hassan T., Corfield A., Reed M., Smolarsky Y., Blaschke S., Jerrentrup C., Hohenstein C., Brunnler F., Ghuysen A., Vranckx M., Ergin M., Dundar Z.D., Altuncu Y.A., Arziman I., Avcil M., Katirci Y., Kokkonen L., Valli J., Kiljunen M., Tolonen J., Kaye S., Makela J., Metsaniitty J., Vaula E., Duytsche N., Garmilla P., Kelly A.-M., Van Meer O., Keijzers G., Motiejunaite J., Jones P., Body R., Craig S., Karamercan M., Klim S., Harjola V.-P., Verschuren F., Holdgate A., Christ M., Golea A., Graham C.A., Capsec J., Barletta C., Garcia-Castrillo L., Kuan W.S., McNulty R., Tan C., Cowell D.L., Jain N., Devillecourt T., Forrester A., Lee K., Chalkley D., Gillett M., Lozzi L., Asha S., Duffy M., Watkins G., Stone R., Rosengren D., Thone J., Martin S., Orda U., Thom O., Kinnear F., Eley R., Ryan A., Morel D., May C., Thomson G., Smith S., Smith R., Maclean A., Grummisch M., Meyer A., Meek R., Rosengarten P., Chan B., Haythorne H., Archer P., Wilson K., Knott J., and Ritchie P.

Published
2020

33. Epidemiology of patients presenting with dyspnea to emergency departments in Europe and the Asia-Pacific region.

Author

Klim S., Graham C., Verschuren F., Capsec J., Christ M., Grammatico-Guillon L., Barletta C., Garcia-Castrillo L., Kelly A.-M., Holdgate A., Harjola V.-P., Craig S., Karamercan M., Jones P., Van Meer O., Motiejunaite J., Body R., Golea A., Kuan W.S., Laribi S., Keijzers G., Klim S., Graham C., Verschuren F., Capsec J., Christ M., Grammatico-Guillon L., Barletta C., Garcia-Castrillo L., Kelly A.-M., Holdgate A., Harjola V.-P., Craig S., Karamercan M., Jones P., Van Meer O., Motiejunaite J., Body R., Golea A., Kuan W.S., Laribi S., and Keijzers G.

Abstract

Objective The primary objective of this study was to describe the epidemiology and management of dyspneic patients presenting to emergency departments (EDs) in an international patient population. Our secondary objective was to compare the EURODEM and AANZDEM patient populations. Patients and methods An observational prospective cohort study was carried out in Europe and the Asia-Pacific region. The study included consecutive patients presenting to EDs with dyspnea as the main complaint. Data were collected on demographics, comorbidities, chronic treatment, clinical signs and investigations, treatment in the ED, diagnosis, and disposition from ED. Results A total of 5569 patients were included in the study. The most common ED diagnoses were lower respiratory tract infection (LRTI) (24.9%), heart failure (HF) (17.3%), chronic obstructive pulmonary disease (COPD) exacerbation (15.8%), and asthma (10.5%) in the overall population. There were more LRTI, HF, and COPD exacerbations in the EURODEM population, whereas asthma was more frequent in the AANZDEM population. ICU admission rates were 5.5%. ED mortality was 0.6%. The overall in-hospital mortality was 5.0%. In-hospital mortality rates were 8.7% for LRTI, 7.6% for HF, and 5.6% for COPD patients. Conclusion Dyspnea as a symptom in the ED has high ward and ICU admission rates. A variety of causes of dyspnea were observed in this study, with chronic diseases accounting for a major proportion.Copyright © 2019 Lippincott Williams and Wilkins. All rights reserved.

Published
2020

34. Get with the guidelines: management of chronic obstructive pulmonary disease in emergency departments in Europe and Australasia is sub-optimal

Author

Kelly, AM, Van Meer, O, Keijzers, G, Motiejunaite, J, Jones, P, Body, R, Craig, S, Karamercan, M, Klim, S, Harjola, VP, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Graham, CA, Capsec, J, Barletta, C, Garcia-Castrillo, L, Kuan, WS, Laribi, S, McNulty, R, Tan, C, Cowell, DL, Jain, N, Devillecourt, T, Forrester, A, Lee, K, Chalkley, D, Gillett, M, Lozzi, L, Asha, S, Duffy, M, Watkins, G, Stone, R, Rosengren, D, Thone, J, Martin, S, Orda, U, Thom, O, Kinnear, F, Eley, R, Ryan, A, Morel, D, May, C, Furyk, Jeremy, Thomson, G, Smith, S, Smith, R, Maclean, A, Grummisch, M, Meyer, A, Meek, R, Rosengarten, P, Chan, B, Haythorne, H, Archer, P, Wilson, K, Knott, J, Ritchie, P, Bryant, M, MacDonald, S, Lee, T, Mahlangu, M, Mountain, D, Rogers, I, Otto, T, Stuart, P, Bament, J, Brown, M, Greven-Garcia, R, Scott, M, Cheri, T, Nguyen, M, Wong, CP, Wong, TW, Leung, LP, Man, CK, Saiboon, IM, Rahman, NH, Lee, WY, Lee, FCY, Russell, SK, Lawoko, C, Al Dandachi, G, Maignan, M, Hermand, DC, Tessier, C, Roy, PM, Bucco, L, Duytsche, N, Garmilla, P, Carbone, G, Cosentini, R, Truță, S, Hrihorișan, N, Cimpoeșu, D, Rotaru, L, Petrică, A, Cojocaru, M, Kelly, AM, Van Meer, O, Keijzers, G, Motiejunaite, J, Jones, P, Body, R, Craig, S, Karamercan, M, Klim, S, Harjola, VP, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Graham, CA, Capsec, J, Barletta, C, Garcia-Castrillo, L, Kuan, WS, Laribi, S, McNulty, R, Tan, C, Cowell, DL, Jain, N, Devillecourt, T, Forrester, A, Lee, K, Chalkley, D, Gillett, M, Lozzi, L, Asha, S, Duffy, M, Watkins, G, Stone, R, Rosengren, D, Thone, J, Martin, S, Orda, U, Thom, O, Kinnear, F, Eley, R, Ryan, A, Morel, D, May, C, Furyk, Jeremy, Thomson, G, Smith, S, Smith, R, Maclean, A, Grummisch, M, Meyer, A, Meek, R, Rosengarten, P, Chan, B, Haythorne, H, Archer, P, Wilson, K, Knott, J, Ritchie, P, Bryant, M, MacDonald, S, Lee, T, Mahlangu, M, Mountain, D, Rogers, I, Otto, T, Stuart, P, Bament, J, Brown, M, Greven-Garcia, R, Scott, M, Cheri, T, Nguyen, M, Wong, CP, Wong, TW, Leung, LP, Man, CK, Saiboon, IM, Rahman, NH, Lee, WY, Lee, FCY, Russell, SK, Lawoko, C, Al Dandachi, G, Maignan, M, Hermand, DC, Tessier, C, Roy, PM, Bucco, L, Duytsche, N, Garmilla, P, Carbone, G, Cosentini, R, Truță, S, Hrihorișan, N, Cimpoeșu, D, Rotaru, L, Petrică, A, and Cojocaru, M

Published
2020

35. Get with the guidelines: management of chronic obstructive pulmonary disease in emergency departments in Europe and Australasia is sub-optimal

Author

Kelly, A-M, Van Meer, O, Keijzers, G, Motiejunaite, J, Jones, P, Body, R, Craig, S, Karamercan, M, Klim, S, Harjola, V-P, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Graham, CA, Capsec, J, Barletta, C, Garcia-Castrillo, L, Kuan, WS, Laribi, S, Kelly, A-M, Van Meer, O, Keijzers, G, Motiejunaite, J, Jones, P, Body, R, Craig, S, Karamercan, M, Klim, S, Harjola, V-P, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Graham, CA, Capsec, J, Barletta, C, Garcia-Castrillo, L, Kuan, WS, and Laribi, S

Abstract

Background Exacerbations of chronic obstructive pulmonary disease (COPD) are common in emergency departments (ED). Guidelines recommend administration of inhaled bronchodilators, systemic corticosteroids and antibiotics along with non-invasive ventilation (NIV) for patients with respiratory acidosis. Aim To determine compliance with guideline recommendations for patients treated for COPD in ED in Europe (EUR) and South East Asia/Australasia (SEA) and to compare management and outcomes. Methods In each region, an observational prospective cohort study was performed that included patients presenting to ED with the main complaint of dyspnoea during three 72-h periods. This planned sub-study included those with an ED primary discharge diagnosis of COPD. Data were collected on demographics, clinical features, treatment, disposition and in-hospital mortality. We determined overall compliance with guideline recommendations and compared treatments and outcome between regions. Results A total of 801 patients was included from 122 ED (66 EUR and 46 SEA). Inhaled bronchodilators were administered to 80.3% of patients, systemic corticosteroids to 59.5%, antibiotics to 44 and 60.6% of patients with pH <7.3 received NIV. The proportion administered systemic corticosteroids was higher in SEA (EUR vs SEA for all comparisons; 52 vs 66%, P < 0.001) as was administration of antibiotics (40 vs 49%, P = 0.02). Rates of NIV and mechanical ventilation were similar. Overall in-hospital mortality was 4.2% (SEA 3.9% vs EUR 4.5%, P = 0.77). Conclusion Compliance with guideline recommended treatments, in particular administration of corticosteroids and NIV, was sub-optimal in both regions. Improved compliance has the potential to improve patient outcome.

Published
2020

36. Seasonal variations of patients presenting dyspnea to emergency departments in Europe: Results from the EURODEM Study

Author

Karamercan, MA, Dundar, ZD, Ergin, M, Van Meer, O, Body, R, Harjola, V-P, Verschuren, F, Christ, M, Golea, A, Capsec, J, Barletta, C, Garcia-Castrillo, L, Altunci, YA, Katirci, Y, Kelly, A-M, Laribi, S, Karamercan, MA, Dundar, ZD, Ergin, M, Van Meer, O, Body, R, Harjola, V-P, Verschuren, F, Christ, M, Golea, A, Capsec, J, Barletta, C, Garcia-Castrillo, L, Altunci, YA, Katirci, Y, Kelly, A-M, and Laribi, S

Abstract

BACKGROUND/AIM: To describe seasonal variations in epidemiology, management, and short-term outcomes of patients in Europe presenting to an emergency department (ED) with a main complaint of dyspnea. MATERIALS AND METHODS: Anobservational prospective cohort study was performed in 66 European EDs which included consecutive patients presenting to EDs with dyspnea as the main complaint during 3 72-h study periods. Data were collected on demographics, comorbidities, chronic treatment, prehospital treatment, mode of arrival of patient to ED, clinical signs at admission, treatment in the ED, ED diagnosis, discharge from ED, and in-hospital outcome. RESULTS: The study included 2524 patients with a median age of 69 (53–80) years old. Of the patients presented, 991 (39.3%) were in autumn, 849 (33.6%) were in spring, and 48 (27.1%) were in winter. The winter population was significantly older (P < 0.001) and had a lower rate of ambulance arrival to ED (P < 0.001). In the winter period, there was a higher rate for lower respiratory tract infection (35.1%), and patients were more hypertensive, more hypoxic, and more hyper/hypothermic compared to other seasons. The ED mortality was about 1% and, in hospital, mortality for admitted patients was 7.4%. CONCLUSION: The analytic method and the outcome of this study may help to guide the allocation of ED resources more efficiently and to recommend seasonal ED management protocols based on the seasonal trend of dyspneic patients.

Published
2020

37. Mitochondrial transfer by human mesenchymal stromal cells ameliorates hepatocyte lipid load in a mouse model of NASH

Author

Hsu, M.-J., Karkossa, Isabel, Schäfer, I., Christ, M., Kühne, H., Schubert, Kristin, Rolle-Kampczyk, Ulrike, Kalkhof, Stefan, Nickel, S., Seibel, P., von Bergen, Martin, Christ, B., Hsu, M.-J., Karkossa, Isabel, Schäfer, I., Christ, M., Kühne, H., Schubert, Kristin, Rolle-Kampczyk, Ulrike, Kalkhof, Stefan, Nickel, S., Seibel, P., von Bergen, Martin, and Christ, B.

Abstract

Mesenchymal stromal cell (MSC) transplantation ameliorated hepatic lipid load; tissue inflammation; and fibrosis in rodent animal models of non-alcoholic steatohepatitis (NASH) by as yet largely unknown mechanism(s). In a mouse model of NASH; we transplanted bone marrow-derived MSCs into the livers; which were analyzed one week thereafter. Combined metabolomic and proteomic data were applied to weighted gene correlation network analysis (WGCNA) and subsequent identification of key drivers. Livers were analyzed histologically and biochemically. The mechanisms of MSC action on hepatocyte lipid accumulation were studied in co-cultures of hepatocytes and MSCs by quantitative image analysis and immunocytochemistry. WGCNA and key driver analysis revealed that NASH caused the impairment of central carbon; amino acid; and lipid metabolism associated with mitochondrial and peroxisomal dysfunction; which was reversed by MSC treatment. MSC improved hepatic lipid metabolism and tissue homeostasis. In co-cultures of hepatocytes and MSCs; the decrease of lipid load was associated with the transfer of mitochondria from the MSCs to the hepatocytes via tunneling nanotubes (TNTs). Hence; MSCs may ameliorate lipid load and tissue perturbance by the donation of mitochondria to the hepatocytes. Thereby; they may provide oxidative capacity for lipid breakdown and thus promote recovery from NASH-induced metabolic impairment and tissue injury.

Published
2020

38. Documenting topographic ecologies in Hong Kong: visual methods for hyper-dense and hyper-topographic urban spaces in landscape architecture

Author

Toland A, Cate Christ M, Toland A, and Cate Christ M

Abstract

© The Author(s) 2020. This article draws on experiments with techniques of visual documentation and representation in circumstances of topographic intensity in Hong Kong. Centrally, the authors ask: how can approaches to visual representation reveal or reframe assemblages of material and immaterial processes in hyper-dense and hyper-topographic urban landscapes? The shaping and reshaping of the ground are essential parts of the formation of recombinant ecosystems, especially in intensively built-up environments – the constant reconfiguration of materials and spaces continually brings into being new ecological conditions. However, the visualization and representation of these transformations are often absent from the repertoire of techniques used to map and understand urban processes. This article addresses how landscape architecture can continue to develop methods to record, represent, visualize and design recombinant ecosystems in our urban environments. It considers which tools and techniques might provide ‘thickened’ understandings of hyper-dense, small-scale and intensely topographic urban environments like Hong Kong, with the objective of assisting designers and planners develop new ways to understand and see public space that can address the human and more-than-human nuances of complex urban spaces over time.

Published
2020

41. Validation of the FAINT risk score in a large prospective international multicenter study

Author

Du Fay De Lavallaz, J, primary, Zimmermann, T, additional, Badertscher, P, additional, Flores, D, additional, Widmer, V, additional, Walter, J, additional, Belkin, M, additional, Boeddinghaus, J, additional, Nestelberger, T, additional, Reichlin, T, additional, Kuehne, M, additional, Christ, M, additional, Miro, O, additional, Martin-Sanchez, J, additional, and Mueller, C, additional

Published
2020
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43. Incidence, characteristics and prognosis of different cardiac etiologies underlying cardiac syncope

Author

Lopez Ayala, P, primary, Flores, D, additional, Zimmermann, T, additional, Du Fay De Lavallaz, J, additional, Nestelberger, T, additional, Strebel, I, additional, Gualandro, D.M, additional, Badertscher, P, additional, Miro, O, additional, Martin-Sanchez, F.J, additional, Geigy, N, additional, Christ, M, additional, Keller, D, additional, Than, M, additional, and Mueller, C, additional

Published
2020
Full Text
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47. Integrated atomic quantum technologies in demanding environments: development and qualification of miniaturized optical setups and integration technologies for UHV and space operation

Author

Christ, M., Kassner, A., Smol, R., Bawamia, A., Peters, A., Wurz, M., Rasel, E., Wicht, A., Krutzik, M., Karafolas, Nikos, Sodnik, Zoran, and Cugny, Bruno

Subjects
Residual gas analysis, Materials science, Outgassing, Adhesive, Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau, Ultra-high vacuum, Space (mathematics), Micro-integration, Quantum technology, Quantum sensors, Development (topology), Systems engineering, Cold atoms, Qualification, ddc:620, Miniaturized optical setups, Konferenzschrift, Environmental testing
Abstract

Employing compact quantum sensors in field or in space (e.g., small satellites) implies demanding requirements on components and integration technologies. Within our work on integrated sensors, we develop miniaturized, ultra-stable optical setups for optical cooling and trapping of cold atomic gases. Besides challenging demands on alignment precision, and thermo-mechanical durability, we specifically address ultra-high vacuum (UHV) compatibility of our integration technologies and optical components. A prototype design of an UHV-compatible, crossed beam optical dipole trap setup and its application within a cold atomic quantum sensor is described. First qualification efforts on adhesive micro-integration technologies are presented. These tests are conducted in application-relevant geometries and material combinations common for micro-integrated optical setups. Adhesive aging will be investigated by thermal cycling or gamma radiation exposure. For vacuum compatibility testing, a versatile UHV testing system is currently being set up, enabling residual gas analysis and measurement of total gas rates down to 5•10-10mbar l/s at a base pressure of 10-11 mbar, exceeding the common ASTM E595 test.

Published
2019

48. Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure The GALACTIC Randomized Clinical Trial

Author

Kozhuharov, N, Goudev, A, Flores, D, Maeder, MT, Walter, J, Shrestha, S, Gualandro, DM, de Oliveira, MT, Sabti, Z, Muller, B, Noveanu, M, Socrates, T, Ziller, R, Bayes-Genis, A, Sionis, A, Simon, P, Michou, E, Gujer, S, Gori, T, Wenzel, P, Pfister, O, Conen, D, Kapos, I, Kobza, R, Rickli, H, Breidthardt, T, Munzel, T, Erne, P, Mueller, C, Dimov, B, Herr, N, Isenrich, R, Mosimann, T, Twerenbold, R, Boeddinghaus, J, Nestelberger, T, Puelacher, C, Freese, M, Vogele, J, Meissner, K, Martin, J, Strebel, I, Wussler, D, Schumacher, C, Osswald, S, Vogt, F, Hilti, J, Schwarz, J, Fitze, B, Hartwiger, S, Arenja, N, Glatz, B, Rentsch, K, Bossa, A, Jallad, S, Soeiro, A, Jansen, T, Gebel, G, Bossard, M, and Christ, M

Abstract

IMPORTANCE Short-term infusions of single vasodilators, usually given in a fixed dose, have not improved outcomes in patients with acute heart failure (AHF). OBJECTIVE To evaluate the effect of a strategy that emphasized early intensive and sustained vasodilation using individualized up-titrated doses of established vasodilators in patients with AHF. DESIGN, SETTING, AND PARTICIPANTS Randomized, open-label blinded-end-point trial enrolling 788 patients hospitalized for AHF with dyspnea, increased plasma concentrations of natriuretic peptides, systolic blood pressure of at least 100mmHg, and plan for treatment in a general ward in 10 tertiary and secondary hospitals in Switzerland, Bulgaria, Germany, Brazil, and Spain. Enrollment began in December 2007 and follow-up was completed in February 2019. INTERVENTIONS Patients were randomized 1:1 to a strategy of early intensive and sustained vasodilation throughout the hospitalization (n = 386) or usual care (n = 402). Early intensive and sustained vasodilation was a comprehensive pragmatic approach of maximal and sustained vasodilation combining individualized doses of sublingual and transdermal nitrates, low-dose oral hydralazine for 48 hours, and rapid up-titration of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or sacubitril-valsartan. MAIN OUTCOMES AND MEASURES The primary end pointwas a composite of all-cause mortality or rehospitalization for AHF at 180 days. RESULTS Among 788 patients randomized, 781 (99.1%; median age, 78 years; 36.9% women) completed the trial and were eligible for primary end point analysis. Follow-up at 180 days was completed for 779 patients (99.7%). The primary end point, a composite of all-cause mortality or rehospitalization for AHF at 180 days, occurred in 117 patients (30.6%) in the intervention group (including 55 deaths [14.4%]) and in 111 patients (27.8%) in the usual care group (including 61 deaths [15.3%]) (absolute difference for the primary end point, 2.8% [95% CI, -3.7% to 9.3%]; adjusted hazard ratio, 1.07 [95% CI, 0.83-1.39]; P =.59). The most common clinically significant adverse events with early intensive and sustained vasodilation vs usual care were hypokalemia (23% vs 25%), worsening renal function (21% vs 20%), headache (26% vs 10%), dizziness (15% vs 10%), and hypotension (8% vs 2%). CONCLUSIONS AND RELEVANCE Among patients with AHF, a strategy of early intensive and sustained vasodilation, compared with usual care, did not significantly improve a composite outcome of all-cause mortality and AHF rehospitalization at 180 days.

Published
2019

49. Combined testing of copeptin and high-sensitivity cardiac troponin T at presentation in comparison to other algorithms for rapid rule-out of acute myocardial infarction

Author

Mueller-Hennessen, M, Lindahl, B, Giannitsis, E, Vafaie, M, Biener, M, Haushofer, AC, Seier, J, Christ, M, Alquezar-Arbe, A, DeFilippi, CR, McCord, J, Body, R, Panteghini, M, Jernberg, T, Plebani, M, Verschuren, F, French, JK, Christenson, RH, Dinkel, C, Katus, HA, Mueller, C, and TRAPID-AMI Investigators

Subjects
Rapid AMI rule-out, Copeptin, Dual-marker strategy, High-sensitivity cardiac troponin T
Abstract

Background: We aimed to directly compare the diagnostic and prognostic performance of a dual maker strategy (DMS) with combined testing of copeptin and high-sensitivity (hs) cardiac troponin T (cTnT) at time of presentation with other algorithms for rapid rule-out of acute myocardial infarction (AM1). Methods: 922 patients presenting to the emergency department with suspected AMI and available baseline copeptin measurements qualified for the present TRAPID-AMI substudy. Diagnostic measures using the DMS (copeptin

Published
2019

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