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2. An Atypical Presentation of Acute Cholecystitis with Left Sided Chest Pain and ST Elevation – A Case Report

Author

Meyer HG, Fäh K, and Christ M

Subjects
electrocardiography, ecg, stemi, cope’s sign, chest pain, case report, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Helene G Meyer,1,2 Kristina Fäh,2 Michael Christ2 1Department of Internal Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland; 2Emergency Department, Lucerne Cantonal Hospital and University of Lucerne, Lucerne, SwitzerlandCorrespondence: Michael Christ, Email michael.christ@luks.chBackground: ST elevation combined with typical chest pain is an indication for acute coronary vascularization and is usually associated with acute myocardial infarction. Herein, we present an unusual case of ST elevation.Case Presentation: A 57-year-old male patient presented to the emergency department with chest pain radiating to both arms and the back. Typical clinical presentation and inferolateral ST elevations were suggestive of ST elevation myocardial infarction. Interestingly, coronary occlusion was excluded by coronary angiography. Despite extensive diagnostic workup, no underlying diagnosis was made. Four days later, the patient returned and reported pain in the right upper abdomen. Clinical presentation, laboratory analysis, and imaging features led to a diagnosis of calculous acute cholecystitis. Laparoscopic cholecystectomy was performed, and the diagnosis was confirmed. Electrocardiographic changes and pain resolved completely.Conclusion: Acute calculous cholecystitis is initiated by gallbladder distension due to biliary duct occlusion caused by gallstones. ST elevations in response to gallbladder distension have been demonstrated in animal models. We hypothesize that the ST elevations observed in this patient with chest pain were linked to stone-mediated distension of the gallbladder, leading to reflex coronary vasoconstriction.Keywords: electrocardiography, ECG, STEMI, cope’s sign, chest pain, case report

Published
2024

4. Historische Obstsorten neu entdeckt: Citizen Science an der Universitätsbibliothek Kiel.

Author

Christ M. A., M. Sc., Andreas and Vetter, Angila

Subjects
*CITIZEN science, *ACADEMIC libraries, *CITIZENS, *FRUIT, *DATA management
Abstract

The project connected to "Obstbuch" from 1859 at Kiel's university library combines historical research with a contemporary digital approach based on citizen science. The involvement of citizen scientists facilitates the botanical analysis of historic fruit varieties to gain insights into the maintenance of varieties. The article introduces methodological approaches, illustrates the significance of botanical research, and discusses aspects of good scientific practice. "Obstbuch" serves as a starting point for the investigation of current issues and relevant societal questions that are researched using citizen science's modern digital methods. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Dengue Fever: Diagnosis, risk stratification, and treatment.

Author

Witte, P., Venturini, S., Meyer, H., Zeller, A., and Christ, M.

Abstract

Background: Dengue fever is a common infectious disease in the tropical and subtropical zones, with more than 100 million symptomatic cases per year. Mosquitoes of the genus Aedes (Aedes aegypti, Aedes albopticus) are vectors of the disease, a spread has led to rising case numbers around the world. Physicians in Europe, too, are increasingly being confronted by this challenge. Methods: This review is based on the findings of a selective search in international publication databases, as well as on the W guideline of 2009 and the current recommendations of the Robert Koch Institute. Results: Dengue fever takes a mild course in more than 90% of cases. Severe dengue fever, up to and including shock and/or mucosal hemorrhages, is rare and carries a mortality of 15%. The disease characteristically takes a triphasic course (febrile p critical phase, recovery phase). I t is diagnosed by the direct demonstration of the pathogen (e.g., with the reverse transcriptas polymerase chain reaction [RT-PCR] up to day 5 of the illness) or by serology. Patients are classified into one of three risk gro depending on their findings and comorbidities and are then treated either as outpatients or in the hospital. The treatment is symptomatic, as no treatment directed against the cause of the disease is available. The key measures are adequate volume replacement and, in patients with hemorrhage, the transfusion of blood products. Preventive steps include vaccination after a documented initial infection and the meticulous avoidance of mosquito bites. Conclusion: Climate change and global mobility have led to a worldwide increase in dengue fever. The disease only rarely takes severe course. In such cases, rapid symptomatic treatment as needed is the key to the avoidance of severe complications. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Production of Sigma{\pm}pi?pK+ in p+p reactions at 3.5 GeV beam energy

Author

Agakishiev, G., Balanda, A., Belver, D., Belyaev, A., Berger-Chen, J. C., Blanco, A., Boehmer, M., Boyard, J. L., Cabanelas, P., Castro, E., Chernenko, S., Destefanis, T. Christ M., Dohrmann, F., Dybczak, A., Epple, E., Fabbietti, L., Fateev, O., Finocchiaro, P., Fonte, P., Friese, J., Fröhlich, I., Galatyuk, T., Garzon, J. A., Gernhäuser, R., Gilardi, C., Golubeva, M., Gonza'lez-Di'az, D., Guber, F., Gumberidze, M., Heinz, T., Hennino, T., Holzmann, R., Ierusalimov, A., Iori, I., Ivashkin, A., Jurkovic, M., Kämpfer, B., Kanaki, K., Karavicheva, T., Koenig, I., Koenig, W., Kolb, B. W., Kotte, R., Kr'asa, A., Krizek, F., Krücken, R., Kuc, H., Kuehn, W., Kugler, A., Kurepin, A., Lalik, R., Lang, S., Lange, J. S., Lapidus, K., Liu, T., Lopes, L., Lorenz, M., Maier, L., Mangiarotti, A., Markert, J., Metag, V., Michalska, B., Michel, J., Morinie're, E., Mousa, J., Müntz, C., Naumann, L., Otwinowski, J., Pachmayer, Y. C., Palka, M., Parpottas, Y., Pechenov, V., Pechenova, O., Pietraszko, J., Przygoda, W., Ramstein, B., Reshetin, A., Rustamov, A., Sadovsky, A., Salabura, P., Schmah, A., Schwab, E., Siebenson, J., Sobolev, Yu. G., Spataro, S., Spruck, B., Ströbele, H., Stroth, J., Sturm, C., Tarantola, A., Teilab, K., Tlusty, P., Traxler, M., Trebacz, R., Tsertos, H., Wagner, V., Weber, M., Wendisch, C., Wüstenfeld, J., Yurevich, S., and Zanevsky, Y.

Subjects
Nuclear Experiment
Abstract

We study the production of Sigma^+-pi^+-pK^+ particle quartets in p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the HADES experiment at GSI. This report evaluates the contribution of resonances like Lambda(1405$, Sigma(1385)^0, Lambda(1520), Delta(1232), N^* and K^*0 to the Sigma^+- pi^-+ p K+ final state. The resulting simulation model is compared to the experimental data in several angular distributions and it shows itself as suitable to evaluate the acceptance corrections properly., Comment: 15 pages, 5 figures

Published
2012
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7. Absolutely continuous spectrum of Stark operators

Author

Christ, M. and Kiselev, A.

Subjects
Mathematics - Spectral Theory, Mathematical Physics, 34L40, 81Q10
Abstract

We prove several new results on the absolutely continuous spectra of perturbed one-dimensional Stark operators. First, we find new classes of perturbations, characterized mainly by smoothness conditions, which preserve purely absolutely continuous spectrum. Then we establish stability of the absolutely continuous spectrum in more general situations, where imbedded singular spectrum may occur. We present two kinds of optimal conditions for the stability of absolutely continuous spectrum: decay and smoothness. In the decay direction, we show that a sufficient (in the power scale) condition is $|q(x)| \leq C(1+|x|)^{-{1/4}-\epsilon};$ in the smoothness direction, a sufficient condition in H\"older classes is $q \in C^{{1/2}+\epsilon}(\reals)$. On the other hand, we show that there exist potentials which both satisfy $|q(x)| \leq C(1+|x|)^{-1/4}$ and belong to $C^{1/2}(\reals)$ for which the spectrum becomes purely singular on the whole real axis, so that the above results are optimal within the scales considered., Comment: 29 pages

Published
2001

8. Scattering and wave operators for one-dimensional Schr\'odinger operators with slowly decaying nonsmooth potentials

Author

Christ, M. and Kiselev, A.

Subjects
Mathematics - Spectral Theory, Mathematical Physics, 34L40, 35P25, 42B20, 81Q10
Abstract

We prove existence of modified wave operators for one-dimensional Schr\"odinger equations with potential in $L^p(\reals)$, $p<2$. If in addition the potential is conditionally integrable, then the usual M\"oller wave operators exist. We also prove asymptotic completeness of these wave operators for some classes of random potentials, and for almost every boundary condition for any given potential., Comment: 46 pages

Published
2001

11. Chest pain in patients with cancer: prevalence of myocardial infarction and diagnostic performance of high-sensitivity cardiac troponin T/I

Author

Bima, P, primary, Lopez-Ayala, P, additional, Koechlin, L, additional, Boeddinghaus, J, additional, Nestelberger, T, additional, Okamura, B, additional, Muench-Gerber, T S, additional, Rubini Gimenez, M, additional, Miro, O, additional, Martin-Sanchez, F J, additional, Christ, M, additional, Keller, D, additional, Lindhal, B, additional, Giannitsis, E, additional, and Mueller, C, additional

Published
2023
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12. On multilinear oscillatory integrals, nonsingular and singular

Author

Christ, M, Li, X C, Tao, T, and Thiele, C

Abstract

Basic questions concerning nonsingular multilinear operators with oscillatory factors are posed and partially answered. L-p norm inequalities are established for multilinear integral operators of Calderon-Zygmund type which incorporate oscillatory factors e(iP), where P is a real-valued polynomial.

Published
2005

13. GBDTMO: as new option for early-stage breast cancer detection and classification using machine learning

Author

Vibith, A. S., Jobin Christ, M. C., Vibith, A. S., and Jobin Christ, M. C.

Abstract

Breast cancer is the second leading cause of disease death in women, after lung and bronchus cancer. According to measurements, mammography misses breast cancer in 10% to 15% of cases for women aged 50 to 69 years. In the current study, we used the Wisconsin breast cancer dataset to develop a two-stage model for breast cancer diagnosis. The main goal of this study effort is to effectively carry out feature selection and classification tasks. Gradient Boosting Decision Tree-based Mayfly Optimisation (GBDTMO), an innovative and efficient breast cancer diagnostic machine learning system, is provided. In the second stage, we employ a Mayfly search to determine which subset of traits is the best. Two more well-known datasets on breast cancer, the ICCR and the Cancer Corpus, were also compared for classification accuracy. The accuracy of the suggested GBDTMO model was higher than that of the existing GBDT and Practical Federated Gradient Boosting Decision Tree (PFGBDT), which had accuracy values of 93.25% and 94.25%, respectively. Similarly, the recall, F-measure, and ROC area values were 98.52%, 97.52%, and 96.32%, respectively. Furthermore, it demonstrated a lower RMSE of 0.98 than the existing GBDT and PFGBDT.

Published
2023

14. External Validation of the SMART Medical Clearance Form for Emergency Patients With Psychiatric Manifestations.

Author

Festini, D., Wthrich, F., and Christ, M.

Abstract

Background: The SMART Medical Clearance Form, developed in the USA, is used to standardize the medical evaluation of emergency patients with primarily psychiatric manifestations. The goal of this study was external validation of the use of this form. Methods: Data were collected retrospectively on emergency patients with psychiatric manifestations. The combined primary clinical endpoint consisted of hospitalization, repeated presentation to the emergency room, and/or death within 30 days. Results: From September 2019 to June 2022, 2404 patients presented with psychiatric manifestations to the emergency room of the Cantonal Hospital of Lucerne, Switzerland, of whom 674 were included in the study. 134 did not satisfy any of the parameters of the SMART Medical Clearance Form (the nSMART group), while 540 satisfied at least one parameter (the pSMART group). In the nSMART group, there were no hospitalizations for a medical indication, no repeated presentations for medical reasons, and no deaths within 30 days. In the pSMART group, there were 90 hospitalizations, 4 repeated presentations, and 4 deaths within 30 days. Although 44% of the patients in the nSMART group underwent further diagnostic studies, such as imaging or laboratory tests, none of these studies led to any change in these patients further clinical management. Conclusion: Use of the SMART Medical Clearance Form apparently enables safe standardized processing of patients with psychiatric manifestations in the emergency room. [ABSTRACT FROM AUTHOR]

Published
2024
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15. GBDTMO: as new option for early-stage breast cancer detection and classification using machine learning.

Author

A. S., Vibith and Christ M C, Jobin

Subjects
MACHINE learning, BREAST cancer, TUMOR classification, EARLY detection of cancer, CANCER diagnosis, FEATURE selection
Abstract

Breast cancer is the second leading cause of disease death in women, after lung and bronchus cancer. According to measurements, mammography misses breast cancer in 10% to 15% of cases for women aged 50 to 69 years. In the current study, we used the Wisconsin breast cancer dataset to develop a two-stage model for breast cancer diagnosis. The main goal of this study effort is to effectively carry out feature selection and classification tasks. Gradient Boosting Decision Tree-based Mayfly Optimisation (GBDTMO), an innovative and efficient breast cancer diagnostic machine learning system, is provided. In the second stage, we employ a Mayfly search to determine which subset of traits is the best. Two more well-known datasets on breast cancer, the ICCR and the Cancer Corpus, were also compared for classification accuracy. The accuracy of the suggested GBDTMO model was higher than that of the existing GBDT and Practical Federated Gradient Boosting Decision Tree (PFGBDT), which had accuracy values of 93.25% and 94.25%, respectively. Similarly, the recall, F-measure, and ROC area values were 98.52%, 97.52%, and 96.32%, respectively. Furthermore, it demonstrated a lower RMSE of 0.98 than the existing GBDT and PFGBDT. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Cardiac arrest teams and time of day: effects on surviving in-hospital resuscitation

Author

Christ M, Dierschke W, von Auenmueller KI, van Bracht M, Grett M, and Trappe HJ

Subjects
Medicine (General), R5-920
Abstract

Martin Christ, Wolfgang Dierschke, Katharina Isabel von Auenmueller, Marc van Bracht, Martin Grett, Hans-Joachim Trappe Department of Cardiology and Angiology, Marienhospital Herne, Ruhr – University Bochum, Herne, Germany Objectives: Little is known about the factors that influence survival following in-hospital resuscitation, but previous investigations have suggested that in-hospital resuscitations outside of regular working hours are associated with worse survival rates. Material and methods: In-hospital cardiac arrest teams at our hospital were instructed to complete a questionnaire following every emergency call between July 2011 and June 2013. Data on all resuscitation attempts were collected and analyzed. Results: A total of 65 in-hospital resuscitations were recorded in 42 males (64.6%) and 23 females (35.4%) (mean age 72.0±14.3 years). A total of 54 (83.1%) cardiac arrests were witnessed; seven (10.8%) showed a shockable rhythm at the time of the first ECG. Resuscitation attempts lasted 29.3±41.3 minutes, and 4.1±3.1 mg epinephrine was given. Return of spontaneous circulation could be achieved in 38 patients (58.5%); 29 (44.6%) survived the first day, 23 (35.4%) the seventh day, and 15 patients (23.1%) were discharged alive. Significantly more in-hospital resuscitations were obtained for those performed during non-regular working hours (P

Published
2014

17. 0/1h-algorithm using a new high-sensitivity cardiac troponin I assay for early diagnosis of myocardial infarction

Author

Koechlin, L, primary, Boeddinghaus, J, additional, Lopez-Ayala, P, additional, Nestelberger, T, additional, Wussler, D, additional, Twerenbold, R, additional, Zimmermann, T, additional, Wildi, K, additional, Miro, O, additional, Martin-Sanchez, J, additional, Keller, D, additional, Christ, M, additional, Buser, A, additional, Rubini Gimenez, M, additional, and Mueller, C, additional

Published
2022
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20. Performance of high-sensitivity cardiac troponin T versus I for the early diagnosis of myocardial infarction

Author

Koechlin, L, primary, Boeddinghaus, J, additional, Lopez-Ayala, P, additional, Nestelberger, T, additional, Miro, O, additional, Wussler, D, additional, Zimmermann, T, additional, Strebel, I, additional, Christ, M, additional, Wildi, K, additional, Rubini Gimenez, M, additional, Martin-Sanchez, J, additional, Keller, D, additional, Twerenbold, R, additional, and Mueller, C, additional

Published
2022
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21. Clinical risk scores versus simple integrated clinical judgment in patients with suspected acute coronary syndromes

Author

Boeddinghaus, J, primary, Meier, M, additional, Nestelberger, T, additional, Koechlin, L, additional, Lopez-Ayala, P, additional, Rubini Gimenez, M, additional, Miro, O, additional, Martin-Sanchez, J, additional, Kawecki, D, additional, Keller, D, additional, Nickel, C, additional, Bingisser, R, additional, Christ, M, additional, and Mueller, C, additional

Published
2022
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22. Extending the no objective testing rules to patients triaged by the ESC 0/1-hour algorithms

Author

Boeddinghaus, J, primary, Ratmann, P D, additional, Nestelberger, T, additional, Lopez-Ayala, P, additional, Koechlin, L, additional, Wildi, K, additional, Miro, O, additional, Martin-Sanchez, J, additional, Christ, M, additional, Gualandro, D, additional, Rubini Gimenez, M, additional, Keller, D, additional, Buser, A, additional, and Mueller, C, additional

Published
2022
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28. This title is unavailable for guests, please login to see more information.

Author

Nickel, S., Vlaic, S., Christ, M., Schubert, Kristin, Henschler, R., Tautenhahn, F., Burger, C., Kühne, H., Erler, S., Roth, A., Wild, C., Brach, J., Hammad, S., Gittel, C., Baunack, M., Lange, U., Broschewitz, J., Stock, P., Metelmann, I., Bartels, M., Pietsch, U.-C., Krämer, S., Eichfeld, U., von Bergen, Martin, Dooley, S., Tautenhahn, H.-M., Christ, B., Nickel, S., Vlaic, S., Christ, M., Schubert, Kristin, Henschler, R., Tautenhahn, F., Burger, C., Kühne, H., Erler, S., Roth, A., Wild, C., Brach, J., Hammad, S., Gittel, C., Baunack, M., Lange, U., Broschewitz, J., Stock, P., Metelmann, I., Bartels, M., Pietsch, U.-C., Krämer, S., Eichfeld, U., von Bergen, Martin, Dooley, S., Tautenhahn, H.-M., and Christ, B.

Published
2021

29. Epidemiology, treatment and outcome of patients with lower respiratory tract infection presenting to emergency departments with dyspnoea (AANZDEM and EuroDEM studies).

Author

Golea A., Garcia-Castrillo L., Laribi S., Kelly A.-M., Body R., Kuan W.S., Harjola V.-P., Jones P., Verschuren F., Holdgate A., Christ M., Graham C.A., Barletta C., Capsec J., Rousseau G., Keijzers G., van Meer O., Craig S., Karamercan M., Klim S., Golea A., Garcia-Castrillo L., Laribi S., Kelly A.-M., Body R., Kuan W.S., Harjola V.-P., Jones P., Verschuren F., Holdgate A., Christ M., Graham C.A., Barletta C., Capsec J., Rousseau G., Keijzers G., van Meer O., Craig S., Karamercan M., and Klim S.

Abstract

Objective: Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania/South-East Asia (SEA) cohorts. Method(s): We conducted a prospective cohort study with three time points in Europe and Oceania/SEA. We included in this manuscript patients presenting to EDs with dyspnoea and a diagnosis of LRTI in ED. We collected comorbidities, chronic medication, clinical signs at arrival, laboratory parameters, ED management and patient outcomes. Result(s): A total of 1389 patients were included, 773 in Europe and 616 in SEA. The European cohort had more comorbidities including chronic heart failure, obesity, chronic obstructive pulmonary disease and smoking. Levels of inflammatory markers were higher in Europe. There were more patients with inflammatory markers in Europe and more hypercapnia in Oceania/SEA. The use of antibiotics was higher in SEA (72.2% vs 61.8%, P < 0.001) whereas intravenous diuretics, non-invasive and invasive ventilation were higher in Europe. Intensive care unit admission rate was 9.9% in Europe cohort and 3.4% in Oceania/SEA cohort. ED mortality was 1% and overall in-hospital mortality was 8.7% with no differences between regions. Conclusion(s): More patients with LRTI in Europe presented with cardio-respiratory comorbidities, they received more adjunct therapies and had a higher intensive care unit admission rate than patients from Oceania/SEA, although mortality was similar between the two cohorts.Copyright © 2020 Australasian College for Emergency Medicine

Published
2021

30. Early standardized clinical judgement for syncope diagnosis in the emergency department

Author

du Fay de Lavallaz, J., Badertscher, P., Zimmermann, T., Nestelberger, T., Walter, J., Strebel, I., Coelho, C., Miró, Salgado, E., Christ, M., Geigy, N., Cullen, L., Than, M., Javier Martin-Sanchez, F., Di Somma, S., Frank Peacock, W., Morawiec, B., Wussler, D., Keller, D. I., Gualandro, D., Michou, E., Kühne, M., Lohrmann, J., Reichlin, T., Mueller, C., Flores, Dayana, Widmer, Velina, Breidthardt, Tobias, Bustamante Mandrión, José, Poepping, Imke, Kawecki, Damian, Muzyk, Piotr, Belkin, Maria, Puelacher, Christian, Lopez Ayala, Pedro, Freese, Michael, Boeddinghaus, Jasper, Diebold, Matthias, Koechlin, Luca, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Campodarve, Isabel, Gea, Joachim, Cruz, Helena Mañé, Calderon, Sofìa, Fuenzalida Inostroza, Carolina Isabel, Briñón, Miguel Angel García, Suárez Cadenas, María, Bingisser, Roland, Osswald, Stefan, other, and, du Fay de Lavallaz, J., Badertscher, P., Zimmermann, T., Nestelberger, T., Walter, J., Strebel, I., Coelho, C., Miró, Salgado, E., Christ, M., Geigy, N., Cullen, L., Than, M., Javier Martin-Sanchez, F., Di Somma, S., Frank Peacock, W., Morawiec, B., Wussler, D., Keller, D. I., Gualandro, D., Michou, E., Kühne, M., Lohrmann, J., Reichlin, T., Mueller, C., Flores, Dayana, Widmer, Velina, Breidthardt, Tobias, Bustamante Mandrión, José, Poepping, Imke, Kawecki, Damian, Muzyk, Piotr, Belkin, Maria, Puelacher, Christian, Lopez Ayala, Pedro, Freese, Michael, Boeddinghaus, Jasper, Diebold, Matthias, Koechlin, Luca, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Campodarve, Isabel, Gea, Joachim, Cruz, Helena Mañé, Calderon, Sofìa, Fuenzalida Inostroza, Carolina Isabel, Briñón, Miguel Angel García, Suárez Cadenas, María, Bingisser, Roland, Osswald, Stefan, and other, and

Abstract

Background: The diagnosis of cardiac syncope remains a challenge in the emergency department (ED). Objective: Assessing the diagnostic accuracy of the early standardized clinical judgement (ESCJ) including a standardized syncope-specific case report form (CRF) in comparison with a recommended multivariable diagnostic score. Methods: In a prospective international observational multicentre study, diagnostic accuracy for cardiac syncope of ESCJ by the ED physician amongst patients ≥ 40 years presenting with syncope to the ED was directly compared with that of the Evaluation of Guidelines in Syncope Study (EGSYS) diagnostic score. Cardiac syncope was centrally adjudicated independently of the ESCJ or conducted workup by two ED specialists based on all information available up to 1-year follow-up. Secondary aims included direct comparison with high-sensitivity cardiac troponin I (hs-cTnI) and B-type natriuretic peptide (BNP) concentrations and a Lasso regression to identify variables contributing most to ESCJ. Results: Cardiac syncope was adjudicated in 252/1494 patients (15.2%). The diagnostic accuracy of ESCJ for cardiac syncope as quantified by the area under the curve (AUC) was 0.87 (95% CI: 0.84–0.89), and higher compared with the EGSYS diagnostic score (0.73 (95% CI: 0.70–0.76)), hs-cTnI (0.77 (95% CI: 0.73–0.80)) and BNP (0.77 (95% CI: 0.74–0.80)), all P < 0.001. Both biomarkers (alone or in combination) on top of the ESCJ significantly improved diagnostic accuracy. Conclusion: ESCJ including a standardized syncope-specific CRF has very high diagnostic accuracy and outperforms the EGSYS score, hs-cTnI and BNP.

Published
2021

31. Epidemiology, treatment and outcome of patients with lower respiratory tract infection presenting to emergency departments with dyspnoea (AANZDEMandEuroDEMstudies)

Author

Rousseau, G, Keijzers, G, van Meer, O, Craig, S, Karamercan, M, Klim, S, Body, R, Kuan, WS, Harjola, V-P, Jones, P, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Capsec, J, Barletta, C, Graham, CA, Garcia-Castrillo, L, Laribi, S, Kelly, A-M, Rousseau, G, Keijzers, G, van Meer, O, Craig, S, Karamercan, M, Klim, S, Body, R, Kuan, WS, Harjola, V-P, Jones, P, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Capsec, J, Barletta, C, Graham, CA, Garcia-Castrillo, L, Laribi, S, and Kelly, A-M

Abstract

OBJECTIVE: Lower respiratory tract infection (LRTI) is a frequent cause of dyspnoea in EDs, and is associated with considerable morbidity and mortality. We described and compared the management of this disease in Europe and Oceania/South-East Asia (SEA) cohorts. METHODS: We conducted a prospective cohort study with three time points in Europe and Oceania/SEA. We included in this manuscript patients presenting to EDs with dyspnoea and a diagnosis of LRTI in ED. We collected comorbidities, chronic medication, clinical signs at arrival, laboratory parameters, ED management and patient outcomes. RESULTS: A total of 1389 patients were included, 773 in Europe and 616 in SEA. The European cohort had more comorbidities including chronic heart failure, obesity, chronic obstructive pulmonary disease and smoking. Levels of inflammatory markers were higher in Europe. There were more patients with inflammatory markers in Europe and more hypercapnia in Oceania/SEA. The use of antibiotics was higher in SEA (72.2% vs 61.8%, P < 0.001) whereas intravenous diuretics, non-invasive and invasive ventilation were higher in Europe. Intensive care unit admission rate was 9.9% in Europe cohort and 3.4% in Oceania/SEA cohort. ED mortality was 1% and overall in-hospital mortality was 8.7% with no differences between regions. CONCLUSIONS: More patients with LRTI in Europe presented with cardio-respiratory comorbidities, they received more adjunct therapies and had a higher intensive care unit admission rate than patients from Oceania/SEA, although mortality was similar between the two cohorts.

Published
2021

35. Validation of the FAINT risk score in a large prospective international multicenter study

Author

Du Fay De Lavallaz, J, primary, Zimmermann, T, additional, Badertscher, P, additional, Flores, D, additional, Widmer, V, additional, Walter, J, additional, Belkin, M, additional, Boeddinghaus, J, additional, Nestelberger, T, additional, Reichlin, T, additional, Kuehne, M, additional, Christ, M, additional, Miro, O, additional, Martin-Sanchez, J, additional, and Mueller, C, additional

Published
2020
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37. Incidence, characteristics and prognosis of different cardiac etiologies underlying cardiac syncope

Author

Lopez Ayala, P, primary, Flores, D, additional, Zimmermann, T, additional, Du Fay De Lavallaz, J, additional, Nestelberger, T, additional, Strebel, I, additional, Gualandro, D.M, additional, Badertscher, P, additional, Miro, O, additional, Martin-Sanchez, F.J, additional, Geigy, N, additional, Christ, M, additional, Keller, D, additional, Than, M, additional, and Mueller, C, additional

Published
2020
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38. Erratum to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC‐GLOSSARI): a multicenter, multinational, 14-day inception cohort study (Intensive Care Medicine, (2016), 42, 5, (953), 10.1007/s00134-016-4317-4)

Author

Auer J., Auer, J, Schatzl, G, Mach, K, Gruber, H, Schreurs, E, Vander Laenen, M, Ceunen, H, Wauters, J, Francois, G, Deschamps, P, Castanares, D, Debels, D, Pierrakos, C, Vincent, J, Taccone, F, Vymazal, T, Gornik, I, Vujiaklija Brajkovic, A, Medici, R, Nielsen, J, Bendtsen, A, Siegel, H, Suonsyrja, T, Hraech, S, Chiche, J, Daviaux, F, Guillot, M, Castelain, V, Losser, R, Novy, E, Timsit, J, Bouadma, L, Misset, B, Philippart, F, Mallat, J, Zogheib, E, Miclo, M, Teboul, J, Anguel, N, Darmon, M, Pham, T, Barberet, G, Plantefeve, G, Floccard, B, Kheladze, Z, Reinhart, K, Sakr, Y, Bloos, F, Faltlhauser, A, Helmes, T, Zacharowski, K, Meybohm, P, Schwarzkopf, K, Christ, M, Baumgaertel, M, John, S, Nentwich, J, Deja, M, Goldmann, A, Gottschalk, A, Honig, F, Siepe, B, Goebel, U, Lehmke, J, Behrens, S, Fiedler, K, Sagoschen, I, Riessen, R, Haap, M, Simon, P, Kaisers, U, Niesen, M, Jaschinski, U, Hoersch, S, Jung, A, Allgaeuer, S, Haake, H, Lange, A, Papanikolaou, M, Balla, M, Giannakou, M, Soultati, I, Nikos, G, Koulouras, V, Kyriazopoulos, G, Gkika, D, Vlachogianni, G, Psaroulis, K, Mouloudi, E, Massa, E, Nichol, A, Meany, E, Motherway, C, Bellani, G, Pota, V, Schiavone, V, Girardis, M, Busani, S, Petrucci, N, Di Pasquale, R, Mazzini, P, Molin, A, Pellerano, G, Volta, C, Spadaro, S, Guarracino, F, Savioli, M, Pellis, T, Chinellato, N, Gatta, A, Cecchini, F, Raineri, S, Cortegiani, A, Kekstas, G, Karosas, V, Anguseva, T, Mitrev, Z, Beck, O, Cimic, N, Janssen, G, Bormans, L, Kuiper, M, Koopmans, K, Den Boer, S, de Groot, M, Dennesen, P, van den Bosch, J, Kluge, G, Mikaszewska-Sokolewicz, M, Lazowski, T, Chruscikowski, M, Machon, J, Adamik, B, Kubler, A, Wieczorek, A, Afonso, S, Matos, R, Catorze, N, Araujo, A, Costa, Z, Pais-de-Lacerda, A, Martins, I, Cardiga, R, Fernandes, L, Serra, I, Martinho, A, Tomescu, D, Popescu, M, Scarlatescu, E, Stoica, R, Macri, A, Filipescu, D, Rupnik, E, Tomic, V, Sifrer, F, Sole Violan, J, Ferrer Aguero, J, Izura, B, Monedero, P, Munos de Cabo, C, Aguilar, G, Belda, F, Blanquer, J, Nives Carbonell, E, Lopez-Delgado, J, Aragon, C, Joya, C, Ortiz-Leyba, C, Fernandez Gonzalez, C, de la Torre-Prados, M, Puerto-Morlan, A, Araujo Aguilar, P, Tomas Marsilla, J, Vera Aratcoz, P, Olmo, A, Ferrer Roca, R, Catalan, R, Garcia Olivares, P, Albis, A, Alvarez, M, Corcoles Gonzalez, V, Gutierrez Rubio, J, Montoiro Allue, R, Rubio Mateo-Sidron, J, Hobrok, M, Cecconi, M, Di Tomasso, N, Raj, A, Szakmany, T, Srinivasa, L, Mathew, S, Ferguson, A, Blahut-Zugaj, M, Watters, M, Henderson, S, Sim, M, Csabi, P, O'Neill, O, Nutt, C, Humphreys, S, Bhowmick, K, Donnelly, A, O'Kane, S, Garfield, M, Jha, R, Unni, N, Gordon, A, Rubulotta, F, Ravi, K, Lunch, G, Franco, F, Higgs, D, Strandvik, G, Jonas, A, Hopkins, P, Hurst, T, Bellini, A, Balogun, O, Srinivasan, R, Ostermann, M, Alexander, P, Mccalman, K, Bedford, J, Fulop, M, Brescia, G, Strachan, J, Meyer, J, Stotz, M, Brett, S, Zand, F, Nikandish, R, Hashemian, S, Jamaati, H, Alsheikhly, A, Almekhlafi, G, Albarrak, M, Maghrabi, A, Salahuddin, N, Aisa, T, Atalan, H, Sungur, M, Hegazi, M, Bauer, P, Mukkera, S, Fried, J, Barger, M, Gueret, R, Gonzalez, C, Lovesio, C, Dellera, C, Barrios, D, Leite Mendes, C, Gottardo, P, Caser, E, Santos, C, Carvalho, A, Teixeira, C, Samaniego, W, Whittle, S, Molano, D, Rojas, A, Guerra, K, Villamagua, B, Salgado-Yepez, E, Morocho, D, Remache-Vargas, N, Namendys-Silva, S, Rodriguez, D, Dominguez, G, Barraza, G, Bermudez-Aceves, E, Sanchez-Hurtado, L, Baltazar-Torres, J, Quispe Sierra, R, Chavez, C, von Osten, I, Van Haren, C, Smalley, N, Kol, M, Wong, H, Smith, R, Yu, L, Wu, X, Chao, L, Zhai, Q, Wu, D, Zhang, X, Jing, X, Bigornia, R, Ikeda-Maquiling, Y, Robles, J, Palo, J, Nguyen, T, Dao, C, Dixit, S, Gurjar, M, Reddy, P, Pravin, A, Simran, S, Ramakrishnan, N, Shetty, R, Udwadia, F, Faraz, M, Indraratna, K, Rajasinhe, J, Auer J., Schatzl G., Mach K., Gruber H., Schreurs E., Vander Laenen M., Ceunen H., Wauters J., Francois G., Deschamps P., Castanares D., Debels D., Pierrakos C., Vincent J. L., Taccone F., Vymazal T., Gornik I., Vujiaklija Brajkovic A., Medici R., Nielsen J., Bendtsen A., Siegel H., Suonsyrja T., Hraech S., Chiche J. -D., Daviaux F., Guillot M., Castelain V., Losser R. -R., Novy E., Timsit J. -F., Bouadma L., Misset B., Philippart F., Mallat J., Zogheib E., Miclo M., Teboul J. -L., Anguel N., Darmon M., Pham T., Barberet G., Plantefeve G., Floccard B., Kheladze Z., Reinhart K., Sakr Y., Bloos F., Faltlhauser A., Helmes T., Zacharowski K., Meybohm P., Schwarzkopf K., Christ M., Baumgaertel M., John S., Nentwich J., Deja M., Goldmann A., Gottschalk A., Honig F., Siepe B., Goebel U., Lehmke J., Behrens S., Fiedler K., Sagoschen I., Riessen R., Haap M., Simon P., Kaisers U., Niesen M., Jaschinski U., Hoersch S., Jung A., Allgaeuer S., Haake H., Lange A., Papanikolaou M., Balla M., Giannakou M., Soultati I., Nikos G., Koulouras V., Kyriazopoulos G., Gkika D., Vlachogianni G., Psaroulis K., Mouloudi E., Massa E., Nichol A., Meany E., Motherway C., Bellani G., Pota V., Schiavone V., Girardis M., Busani S., Petrucci N., Di Pasquale R., Mazzini P., Molin A., Pellerano G., Volta C., Spadaro S., Guarracino F., Savioli M., Pellis T., Chinellato N., Gatta A., Cecchini F., Raineri S. M., Cortegiani A., Kekstas G., Karosas V., Anguseva T., Mitrev Z., Beck O., Cimic N., Janssen G., Bormans L., Kuiper M., Koopmans K., Den Boer S., de Groot M., Dennesen P., van den Bosch J., Kluge G., Mikaszewska-Sokolewicz M., Lazowski T., Chruscikowski M., Machon J., Adamik B., Kubler A., Wieczorek A., Afonso S., Matos R., Catorze N., Araujo A., Costa Z., Pais-de-Lacerda A., Martins I., Cardiga R., Fernandes L., Serra I., Martinho A., Tomescu D., Popescu M., Scarlatescu E., Stoica R., Macri A., Filipescu D., Rupnik E., Tomic V., Sifrer F., Sole Violan J., Ferrer Aguero J. M., Izura B. J., Monedero P., Munos de Cabo C., Aguilar G., Belda F. J., Blanquer J., Nives Carbonell E., Lopez-Delgado J. -C., Aragon C., Joya C., Ortiz-Leyba C., Fernandez Gonzalez C. J., de la Torre-Prados M. -V., Puerto-Morlan A., Araujo Aguilar P., Tomas Marsilla J. I., Vera Aratcoz P., Olmo A., Ferrer Roca R., Catalan R. M., Garcia Olivares P., Albis A., Alvarez M., Corcoles Gonzalez V., Gutierrez Rubio J. M., Montoiro Allue R., Rubio Mateo-Sidron J., Hobrok M., Cecconi M., Di Tomasso N., Raj A., Szakmany T., Srinivasa L., Mathew S., Ferguson A., Blahut-Zugaj M., Watters M., Henderson S., Sim M., Csabi P., O'Neill O., Nutt C., Humphreys S., Bhowmick K., Donnelly A., O'Kane S., Garfield M., Jha R., Unni N., Gordon A., Rubulotta F., Ravi K., Lunch G., Franco F., Higgs D., Strandvik G., Jonas A., Hopkins P., Hurst T., Bellini A., Balogun O., Srinivasan R., Ostermann M., Alexander P., McCalman K., Bedford J., Fulop M., Brescia G., Strachan J., Meyer J., Stotz M., Brett S., Zand F., Nikandish R., Hashemian S., Jamaati H., Alsheikhly A. S., Almekhlafi G., Albarrak M., Maghrabi A., Salahuddin N., Aisa T., Atalan H. K., Sungur M., Hegazi M., Bauer P., Mukkera S., Fried J., Barger M., Gueret R., Gonzalez C., Lovesio C., Dellera C., Barrios D., Leite Mendes C., Gottardo P., Caser E., Santos C., Carvalho A., Teixeira C., Samaniego W., Whittle S., Molano D., Rojas A., Guerra K., Villamagua B., Salgado-Yepez E., Morocho D., Remache-Vargas N., Namendys-Silva S., Rodriguez D., Dominguez G., Barraza G., Bermudez-Aceves E., Sanchez-Hurtado L. A., Baltazar-Torres J. A., Quispe Sierra R., Chavez C., von Osten I., Van Haren C., Smalley N., Kol M., Wong H., Smith R., Yu L., Wu X., Chao L., Zhai Q., Wu D., Zhang X., Jing X., Bigornia R., Ikeda-Maquiling Y., Robles J., Palo J. E., Nguyen T., Dao C., Dixit S., Gurjar M., Reddy P., Pravin A., Simran S., Ramakrishnan N., Shetty R., Udwadia F., Faraz M., Indraratna K., Rajasinhe J., Auer J., Auer, J, Schatzl, G, Mach, K, Gruber, H, Schreurs, E, Vander Laenen, M, Ceunen, H, Wauters, J, Francois, G, Deschamps, P, Castanares, D, Debels, D, Pierrakos, C, Vincent, J, Taccone, F, Vymazal, T, Gornik, I, Vujiaklija Brajkovic, A, Medici, R, Nielsen, J, Bendtsen, A, Siegel, H, Suonsyrja, T, Hraech, S, Chiche, J, Daviaux, F, Guillot, M, Castelain, V, Losser, R, Novy, E, Timsit, J, Bouadma, L, Misset, B, Philippart, F, Mallat, J, Zogheib, E, Miclo, M, Teboul, J, Anguel, N, Darmon, M, Pham, T, Barberet, G, Plantefeve, G, Floccard, B, Kheladze, Z, Reinhart, K, Sakr, Y, Bloos, F, Faltlhauser, A, Helmes, T, Zacharowski, K, Meybohm, P, Schwarzkopf, K, Christ, M, Baumgaertel, M, John, S, Nentwich, J, Deja, M, Goldmann, A, Gottschalk, A, Honig, F, Siepe, B, Goebel, U, Lehmke, J, Behrens, S, Fiedler, K, Sagoschen, I, Riessen, R, Haap, M, Simon, P, Kaisers, U, Niesen, M, Jaschinski, U, Hoersch, S, Jung, A, Allgaeuer, S, Haake, H, Lange, A, Papanikolaou, M, Balla, M, Giannakou, M, Soultati, I, Nikos, G, Koulouras, V, Kyriazopoulos, G, Gkika, D, Vlachogianni, G, Psaroulis, K, Mouloudi, E, Massa, E, Nichol, A, Meany, E, Motherway, C, Bellani, G, Pota, V, Schiavone, V, Girardis, M, Busani, S, Petrucci, N, Di Pasquale, R, Mazzini, P, Molin, A, Pellerano, G, Volta, C, Spadaro, S, Guarracino, F, Savioli, M, Pellis, T, Chinellato, N, Gatta, A, Cecchini, F, Raineri, S, Cortegiani, A, Kekstas, G, Karosas, V, Anguseva, T, Mitrev, Z, Beck, O, Cimic, N, Janssen, G, Bormans, L, Kuiper, M, Koopmans, K, Den Boer, S, de Groot, M, Dennesen, P, van den Bosch, J, Kluge, G, Mikaszewska-Sokolewicz, M, Lazowski, T, Chruscikowski, M, Machon, J, Adamik, B, Kubler, A, Wieczorek, A, Afonso, S, Matos, R, Catorze, N, Araujo, A, Costa, Z, Pais-de-Lacerda, A, Martins, I, Cardiga, R, Fernandes, L, Serra, I, Martinho, A, Tomescu, D, Popescu, M, Scarlatescu, E, Stoica, R, Macri, A, Filipescu, D, Rupnik, E, Tomic, V, Sifrer, F, Sole Violan, J, Ferrer Aguero, J, Izura, B, Monedero, P, Munos de Cabo, C, Aguilar, G, Belda, F, Blanquer, J, Nives Carbonell, E, Lopez-Delgado, J, Aragon, C, Joya, C, Ortiz-Leyba, C, Fernandez Gonzalez, C, de la Torre-Prados, M, Puerto-Morlan, A, Araujo Aguilar, P, Tomas Marsilla, J, Vera Aratcoz, P, Olmo, A, Ferrer Roca, R, Catalan, R, Garcia Olivares, P, Albis, A, Alvarez, M, Corcoles Gonzalez, V, Gutierrez Rubio, J, Montoiro Allue, R, Rubio Mateo-Sidron, J, Hobrok, M, Cecconi, M, Di Tomasso, N, Raj, A, Szakmany, T, Srinivasa, L, Mathew, S, Ferguson, A, Blahut-Zugaj, M, Watters, M, Henderson, S, Sim, M, Csabi, P, O'Neill, O, Nutt, C, Humphreys, S, Bhowmick, K, Donnelly, A, O'Kane, S, Garfield, M, Jha, R, Unni, N, Gordon, A, Rubulotta, F, Ravi, K, Lunch, G, Franco, F, Higgs, D, Strandvik, G, Jonas, A, Hopkins, P, Hurst, T, Bellini, A, Balogun, O, Srinivasan, R, Ostermann, M, Alexander, P, Mccalman, K, Bedford, J, Fulop, M, Brescia, G, Strachan, J, Meyer, J, Stotz, M, Brett, S, Zand, F, Nikandish, R, Hashemian, S, Jamaati, H, Alsheikhly, A, Almekhlafi, G, Albarrak, M, Maghrabi, A, Salahuddin, N, Aisa, T, Atalan, H, Sungur, M, Hegazi, M, Bauer, P, Mukkera, S, Fried, J, Barger, M, Gueret, R, Gonzalez, C, Lovesio, C, Dellera, C, Barrios, D, Leite Mendes, C, Gottardo, P, Caser, E, Santos, C, Carvalho, A, Teixeira, C, Samaniego, W, Whittle, S, Molano, D, Rojas, A, Guerra, K, Villamagua, B, Salgado-Yepez, E, Morocho, D, Remache-Vargas, N, Namendys-Silva, S, Rodriguez, D, Dominguez, G, Barraza, G, Bermudez-Aceves, E, Sanchez-Hurtado, L, Baltazar-Torres, J, Quispe Sierra, R, Chavez, C, von Osten, I, Van Haren, C, Smalley, N, Kol, M, Wong, H, Smith, R, Yu, L, Wu, X, Chao, L, Zhai, Q, Wu, D, Zhang, X, Jing, X, Bigornia, R, Ikeda-Maquiling, Y, Robles, J, Palo, J, Nguyen, T, Dao, C, Dixit, S, Gurjar, M, Reddy, P, Pravin, A, Simran, S, Ramakrishnan, N, Shetty, R, Udwadia, F, Faraz, M, Indraratna, K, Rajasinhe, J, Auer J., Schatzl G., Mach K., Gruber H., Schreurs E., Vander Laenen M., Ceunen H., Wauters J., Francois G., Deschamps P., Castanares D., Debels D., Pierrakos C., Vincent J. L., Taccone F., Vymazal T., Gornik I., Vujiaklija Brajkovic A., Medici R., Nielsen J., Bendtsen A., Siegel H., Suonsyrja T., Hraech S., Chiche J. -D., Daviaux F., Guillot M., Castelain V., Losser R. -R., Novy E., Timsit J. -F., Bouadma L., Misset B., Philippart F., Mallat J., Zogheib E., Miclo M., Teboul J. -L., Anguel N., Darmon M., Pham T., Barberet G., Plantefeve G., Floccard B., Kheladze Z., Reinhart K., Sakr Y., Bloos F., Faltlhauser A., Helmes T., Zacharowski K., Meybohm P., Schwarzkopf K., Christ M., Baumgaertel M., John S., Nentwich J., Deja M., Goldmann A., Gottschalk A., Honig F., Siepe B., Goebel U., Lehmke J., Behrens S., Fiedler K., Sagoschen I., Riessen R., Haap M., Simon P., Kaisers U., Niesen M., Jaschinski U., Hoersch S., Jung A., Allgaeuer S., Haake H., Lange A., Papanikolaou M., Balla M., Giannakou M., Soultati I., Nikos G., Koulouras V., Kyriazopoulos G., Gkika D., Vlachogianni G., Psaroulis K., Mouloudi E., Massa E., Nichol A., Meany E., Motherway C., Bellani G., Pota V., Schiavone V., Girardis M., Busani S., Petrucci N., Di Pasquale R., Mazzini P., Molin A., Pellerano G., Volta C., Spadaro S., Guarracino F., Savioli M., Pellis T., Chinellato N., Gatta A., Cecchini F., Raineri S. M., Cortegiani A., Kekstas G., Karosas V., Anguseva T., Mitrev Z., Beck O., Cimic N., Janssen G., Bormans L., Kuiper M., Koopmans K., Den Boer S., de Groot M., Dennesen P., van den Bosch J., Kluge G., Mikaszewska-Sokolewicz M., Lazowski T., Chruscikowski M., Machon J., Adamik B., Kubler A., Wieczorek A., Afonso S., Matos R., Catorze N., Araujo A., Costa Z., Pais-de-Lacerda A., Martins I., Cardiga R., Fernandes L., Serra I., Martinho A., Tomescu D., Popescu M., Scarlatescu E., Stoica R., Macri A., Filipescu D., Rupnik E., Tomic V., Sifrer F., Sole Violan J., Ferrer Aguero J. M., Izura B. J., Monedero P., Munos de Cabo C., Aguilar G., Belda F. J., Blanquer J., Nives Carbonell E., Lopez-Delgado J. -C., Aragon C., Joya C., Ortiz-Leyba C., Fernandez Gonzalez C. J., de la Torre-Prados M. -V., Puerto-Morlan A., Araujo Aguilar P., Tomas Marsilla J. I., Vera Aratcoz P., Olmo A., Ferrer Roca R., Catalan R. M., Garcia Olivares P., Albis A., Alvarez M., Corcoles Gonzalez V., Gutierrez Rubio J. M., Montoiro Allue R., Rubio Mateo-Sidron J., Hobrok M., Cecconi M., Di Tomasso N., Raj A., Szakmany T., Srinivasa L., Mathew S., Ferguson A., Blahut-Zugaj M., Watters M., Henderson S., Sim M., Csabi P., O'Neill O., Nutt C., Humphreys S., Bhowmick K., Donnelly A., O'Kane S., Garfield M., Jha R., Unni N., Gordon A., Rubulotta F., Ravi K., Lunch G., Franco F., Higgs D., Strandvik G., Jonas A., Hopkins P., Hurst T., Bellini A., Balogun O., Srinivasan R., Ostermann M., Alexander P., McCalman K., Bedford J., Fulop M., Brescia G., Strachan J., Meyer J., Stotz M., Brett S., Zand F., Nikandish R., Hashemian S., Jamaati H., Alsheikhly A. S., Almekhlafi G., Albarrak M., Maghrabi A., Salahuddin N., Aisa T., Atalan H. K., Sungur M., Hegazi M., Bauer P., Mukkera S., Fried J., Barger M., Gueret R., Gonzalez C., Lovesio C., Dellera C., Barrios D., Leite Mendes C., Gottardo P., Caser E., Santos C., Carvalho A., Teixeira C., Samaniego W., Whittle S., Molano D., Rojas A., Guerra K., Villamagua B., Salgado-Yepez E., Morocho D., Remache-Vargas N., Namendys-Silva S., Rodriguez D., Dominguez G., Barraza G., Bermudez-Aceves E., Sanchez-Hurtado L. A., Baltazar-Torres J. A., Quispe Sierra R., Chavez C., von Osten I., Van Haren C., Smalley N., Kol M., Wong H., Smith R., Yu L., Wu X., Chao L., Zhai Q., Wu D., Zhang X., Jing X., Bigornia R., Ikeda-Maquiling Y., Robles J., Palo J. E., Nguyen T., Dao C., Dixit S., Gurjar M., Reddy P., Pravin A., Simran S., Ramakrishnan N., Shetty R., Udwadia F., Faraz M., Indraratna K., and Rajasinhe J.

Abstract

In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to list the members of the groups here: (Table presented.).

Published
2018

41. Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicentre single-arm clinical trial

Author

Schmidtmann, I. (Irene), Ageno, W. (Walter), Bauersachs, R.M. (Rupert M.), Becattini, C. (Cecilia), Bernardi, E. (Enrico), Beyer-Westendorf, J. (Jan), Bonacchini, L. (Luca), Brachmann, J. (Johannes), Christ, M. (Michael), Czihal, M. (Michael), Duerschmied, D. (Daniel), Empen, K. (Klaus), Espinola-Klein, C. (Christine), Ficker, J.H. (Joachim H.), Fonseca, C. (Candida), Genth-Zotz, S. (Sabine), Jiménez, D. (David), Harjola, V.P. (Veli-Pekka), Held, M. (Matthias), Iogna-Prat, L. (Lorenzo), Lange, T.J. (Tobias J.), Manolis, A. (Athanasios), Meyer, A. (Andreas), Mustonen, P. (Pirjo), Rauch-Kroehnert, U. (Ursula), Ruiz-Artacho, P. (Pedro), Schellong, S. (Sebastian), Schwaiblmair, M. (Martin), Stahrenberg, R. (Raoul), Westerweel, P.E. (Peter), Wild, P.S. (Philipp S.), Konstantinides, S.V. (Stavros V.), and Lankeit, M. (Mareike)

Subjects
Rivaroxaban, Pulmonary embolism, Home treatment, Management trial, Right ventricular dysfunction, Risk stratification
Abstract

Aims To investigate the efficacy and safety of early transition from hospital to ambulatory treatment in low-risk acute PE, using the oral factor Xa inhibitor rivaroxaban. Methods and results We conducted a prospective multicentre single-arm investigator initiated and academically sponsored management trial in patients with acute low-risk PE (EudraCT Identifier 2013-001657-28). Eligibility criteria included absence of (i) haemodynamic instability, (ii) right ventricular dysfunction or intracardiac thrombi, and (iii) serious comorbidities. Up to two nights of hospital stay were permitted. Rivaroxaban was given at the approved dose for PE for >_3 months. The primary outcome was symptomatic recurrent venous thromboembolism (VTE) or PE-related death within 3 months of enrolment. An interim analysis was planned after the first 525 patients, with prespecified early termination of the study if the null hypothesis could be rejected at the level of a = 0.004 (

Published
2020

43. Integrated atomic quantum technologies in demanding environments: development and qualification of miniaturized optical setups and integration technologies for UHV and space operation

Author

Christ, M., Kassner, A., Smol, R., Bawamia, A., Peters, A., Wurz, M., Rasel, E., Wicht, A., Krutzik, M., Karafolas, Nikos, Sodnik, Zoran, and Cugny, Bruno

Subjects
Residual gas analysis, Materials science, Outgassing, Adhesive, Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau, Ultra-high vacuum, Space (mathematics), Micro-integration, Quantum technology, Quantum sensors, Development (topology), Systems engineering, Cold atoms, Qualification, ddc:620, Miniaturized optical setups, Konferenzschrift, Environmental testing
Abstract

Employing compact quantum sensors in field or in space (e.g., small satellites) implies demanding requirements on components and integration technologies. Within our work on integrated sensors, we develop miniaturized, ultra-stable optical setups for optical cooling and trapping of cold atomic gases. Besides challenging demands on alignment precision, and thermo-mechanical durability, we specifically address ultra-high vacuum (UHV) compatibility of our integration technologies and optical components. A prototype design of an UHV-compatible, crossed beam optical dipole trap setup and its application within a cold atomic quantum sensor is described. First qualification efforts on adhesive micro-integration technologies are presented. These tests are conducted in application-relevant geometries and material combinations common for micro-integrated optical setups. Adhesive aging will be investigated by thermal cycling or gamma radiation exposure. For vacuum compatibility testing, a versatile UHV testing system is currently being set up, enabling residual gas analysis and measurement of total gas rates down to 5•10-10mbar l/s at a base pressure of 10-11 mbar, exceeding the common ASTM E595 test.

Published
2019
Full Text
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47. Interaction of holmium laser radiation and cortical bone: ablation and thermal damage in a turbid medium

Author

Barton, T.G., Foth, H.-J., Christ, M., and Hormann, K.

Subjects
Tissues -- Analysis, Laser beams -- Analysis, Photons -- Scattering, Astronomy, Physics
Abstract

The ablation of cortical bone by holmium laser radiation is described by experimental values of the ablation rate, the depth of tissue damage, and the tissue temperature. An ablation model is presented on the basis of photon diffusion in a turbid medium. When this model is compared with experimental results for the ablation rate, the penetration depth is determined. The expansion of the laser-induced heat can be explained by a point heat source located in a distance beneath the surface equal to the ablation depth. The accumulation of heat as a function of the repetition rate of the laser leads to a limitation of the repetition rate. In order to avoid traumatic heat accumulation, a maximum repetition rate should not be exceeded. Key words: Bone ablation, Ho:YAG laser, turbid medium, penetration depth, thermal damage, heat accumulation.

Published
1997

48. Get with the guidelines: management of chronic obstructive pulmonary disease in emergency departments in Europe and Australasia is sub-optimal.

Author

Furyk J., Stuart P., Bament J., Brown M., Greven-Garcia R., Scott M., Cheri T., Nguyen M., Wong C.-P., Wong T.W., Leung L.-P., Man C.K., Bryant M., MacDonald S., Lee T., Mahlangu M., Mountain D., Rogers I., Otto T., Saiboon I.M., Rahman N.H., Lee W.Y., Lee F.C.Y., Russell S., Lawoko C., Laribi S., Al Dandachi G., Maignan M., Hermand D., Tessier C., Roy P.-M., Bucco L., Carbone G., Cosentini R., Truta S., Hrihorisan N., Cimpoesu D., Rotaru L., Petrica A., Cojocaru M., Nica S., Tudoran R., Vecerdi C., Puticiu M., Schonberger T., Coolsma C., Baggelaar M., Fransen N., van den Brand C., Idzenga D., Maas M., Franssen M., Mackaij-Staal C., Schutte L., de Kubber M., Mignot-Evers L., Penninga-Puister U., Jansen J., Kuijten J., Bouwhuis M., Reuben A., Smith J., Ramlakhan S., Darwent M., Gagg J., Keating L., Bongale S., Hardy E., Keep J., Jarman H., Crane S., Lawal O., Hassan T., Corfield A., Reed M., Smolarsky Y., Blaschke S., Jerrentrup C., Hohenstein C., Brunnler F., Ghuysen A., Vranckx M., Ergin M., Dundar Z.D., Altuncu Y.A., Arziman I., Avcil M., Katirci Y., Kokkonen L., Valli J., Kiljunen M., Tolonen J., Kaye S., Makela J., Metsaniitty J., Vaula E., Duytsche N., Garmilla P., Kelly A.-M., Van Meer O., Keijzers G., Motiejunaite J., Jones P., Body R., Craig S., Karamercan M., Klim S., Harjola V.-P., Verschuren F., Holdgate A., Christ M., Golea A., Graham C.A., Capsec J., Barletta C., Garcia-Castrillo L., Kuan W.S., McNulty R., Tan C., Cowell D.L., Jain N., Devillecourt T., Forrester A., Lee K., Chalkley D., Gillett M., Lozzi L., Asha S., Duffy M., Watkins G., Stone R., Rosengren D., Thone J., Martin S., Orda U., Thom O., Kinnear F., Eley R., Ryan A., Morel D., May C., Thomson G., Smith S., Smith R., Maclean A., Grummisch M., Meyer A., Meek R., Rosengarten P., Chan B., Haythorne H., Archer P., Wilson K., Knott J., Ritchie P., Furyk J., Stuart P., Bament J., Brown M., Greven-Garcia R., Scott M., Cheri T., Nguyen M., Wong C.-P., Wong T.W., Leung L.-P., Man C.K., Bryant M., MacDonald S., Lee T., Mahlangu M., Mountain D., Rogers I., Otto T., Saiboon I.M., Rahman N.H., Lee W.Y., Lee F.C.Y., Russell S., Lawoko C., Laribi S., Al Dandachi G., Maignan M., Hermand D., Tessier C., Roy P.-M., Bucco L., Carbone G., Cosentini R., Truta S., Hrihorisan N., Cimpoesu D., Rotaru L., Petrica A., Cojocaru M., Nica S., Tudoran R., Vecerdi C., Puticiu M., Schonberger T., Coolsma C., Baggelaar M., Fransen N., van den Brand C., Idzenga D., Maas M., Franssen M., Mackaij-Staal C., Schutte L., de Kubber M., Mignot-Evers L., Penninga-Puister U., Jansen J., Kuijten J., Bouwhuis M., Reuben A., Smith J., Ramlakhan S., Darwent M., Gagg J., Keating L., Bongale S., Hardy E., Keep J., Jarman H., Crane S., Lawal O., Hassan T., Corfield A., Reed M., Smolarsky Y., Blaschke S., Jerrentrup C., Hohenstein C., Brunnler F., Ghuysen A., Vranckx M., Ergin M., Dundar Z.D., Altuncu Y.A., Arziman I., Avcil M., Katirci Y., Kokkonen L., Valli J., Kiljunen M., Tolonen J., Kaye S., Makela J., Metsaniitty J., Vaula E., Duytsche N., Garmilla P., Kelly A.-M., Van Meer O., Keijzers G., Motiejunaite J., Jones P., Body R., Craig S., Karamercan M., Klim S., Harjola V.-P., Verschuren F., Holdgate A., Christ M., Golea A., Graham C.A., Capsec J., Barletta C., Garcia-Castrillo L., Kuan W.S., McNulty R., Tan C., Cowell D.L., Jain N., Devillecourt T., Forrester A., Lee K., Chalkley D., Gillett M., Lozzi L., Asha S., Duffy M., Watkins G., Stone R., Rosengren D., Thone J., Martin S., Orda U., Thom O., Kinnear F., Eley R., Ryan A., Morel D., May C., Thomson G., Smith S., Smith R., Maclean A., Grummisch M., Meyer A., Meek R., Rosengarten P., Chan B., Haythorne H., Archer P., Wilson K., Knott J., and Ritchie P.

Published
2020

49. Epidemiology of patients presenting with dyspnea to emergency departments in Europe and the Asia-Pacific region.

Author

Klim S., Graham C., Verschuren F., Capsec J., Christ M., Grammatico-Guillon L., Barletta C., Garcia-Castrillo L., Kelly A.-M., Holdgate A., Harjola V.-P., Craig S., Karamercan M., Jones P., Van Meer O., Motiejunaite J., Body R., Golea A., Kuan W.S., Laribi S., Keijzers G., Klim S., Graham C., Verschuren F., Capsec J., Christ M., Grammatico-Guillon L., Barletta C., Garcia-Castrillo L., Kelly A.-M., Holdgate A., Harjola V.-P., Craig S., Karamercan M., Jones P., Van Meer O., Motiejunaite J., Body R., Golea A., Kuan W.S., Laribi S., and Keijzers G.

Abstract

Objective The primary objective of this study was to describe the epidemiology and management of dyspneic patients presenting to emergency departments (EDs) in an international patient population. Our secondary objective was to compare the EURODEM and AANZDEM patient populations. Patients and methods An observational prospective cohort study was carried out in Europe and the Asia-Pacific region. The study included consecutive patients presenting to EDs with dyspnea as the main complaint. Data were collected on demographics, comorbidities, chronic treatment, clinical signs and investigations, treatment in the ED, diagnosis, and disposition from ED. Results A total of 5569 patients were included in the study. The most common ED diagnoses were lower respiratory tract infection (LRTI) (24.9%), heart failure (HF) (17.3%), chronic obstructive pulmonary disease (COPD) exacerbation (15.8%), and asthma (10.5%) in the overall population. There were more LRTI, HF, and COPD exacerbations in the EURODEM population, whereas asthma was more frequent in the AANZDEM population. ICU admission rates were 5.5%. ED mortality was 0.6%. The overall in-hospital mortality was 5.0%. In-hospital mortality rates were 8.7% for LRTI, 7.6% for HF, and 5.6% for COPD patients. Conclusion Dyspnea as a symptom in the ED has high ward and ICU admission rates. A variety of causes of dyspnea were observed in this study, with chronic diseases accounting for a major proportion.Copyright © 2019 Lippincott Williams and Wilkins. All rights reserved.

Published
2020

50. Get with the guidelines: management of chronic obstructive pulmonary disease in emergency departments in Europe and Australasia is sub-optimal

Author

Kelly, AM, Van Meer, O, Keijzers, G, Motiejunaite, J, Jones, P, Body, R, Craig, S, Karamercan, M, Klim, S, Harjola, VP, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Graham, CA, Capsec, J, Barletta, C, Garcia-Castrillo, L, Kuan, WS, Laribi, S, McNulty, R, Tan, C, Cowell, DL, Jain, N, Devillecourt, T, Forrester, A, Lee, K, Chalkley, D, Gillett, M, Lozzi, L, Asha, S, Duffy, M, Watkins, G, Stone, R, Rosengren, D, Thone, J, Martin, S, Orda, U, Thom, O, Kinnear, F, Eley, R, Ryan, A, Morel, D, May, C, Furyk, Jeremy, Thomson, G, Smith, S, Smith, R, Maclean, A, Grummisch, M, Meyer, A, Meek, R, Rosengarten, P, Chan, B, Haythorne, H, Archer, P, Wilson, K, Knott, J, Ritchie, P, Bryant, M, MacDonald, S, Lee, T, Mahlangu, M, Mountain, D, Rogers, I, Otto, T, Stuart, P, Bament, J, Brown, M, Greven-Garcia, R, Scott, M, Cheri, T, Nguyen, M, Wong, CP, Wong, TW, Leung, LP, Man, CK, Saiboon, IM, Rahman, NH, Lee, WY, Lee, FCY, Russell, SK, Lawoko, C, Al Dandachi, G, Maignan, M, Hermand, DC, Tessier, C, Roy, PM, Bucco, L, Duytsche, N, Garmilla, P, Carbone, G, Cosentini, R, Truță, S, Hrihorișan, N, Cimpoeșu, D, Rotaru, L, Petrică, A, Cojocaru, M, Kelly, AM, Van Meer, O, Keijzers, G, Motiejunaite, J, Jones, P, Body, R, Craig, S, Karamercan, M, Klim, S, Harjola, VP, Verschuren, F, Holdgate, A, Christ, M, Golea, A, Graham, CA, Capsec, J, Barletta, C, Garcia-Castrillo, L, Kuan, WS, Laribi, S, McNulty, R, Tan, C, Cowell, DL, Jain, N, Devillecourt, T, Forrester, A, Lee, K, Chalkley, D, Gillett, M, Lozzi, L, Asha, S, Duffy, M, Watkins, G, Stone, R, Rosengren, D, Thone, J, Martin, S, Orda, U, Thom, O, Kinnear, F, Eley, R, Ryan, A, Morel, D, May, C, Furyk, Jeremy, Thomson, G, Smith, S, Smith, R, Maclean, A, Grummisch, M, Meyer, A, Meek, R, Rosengarten, P, Chan, B, Haythorne, H, Archer, P, Wilson, K, Knott, J, Ritchie, P, Bryant, M, MacDonald, S, Lee, T, Mahlangu, M, Mountain, D, Rogers, I, Otto, T, Stuart, P, Bament, J, Brown, M, Greven-Garcia, R, Scott, M, Cheri, T, Nguyen, M, Wong, CP, Wong, TW, Leung, LP, Man, CK, Saiboon, IM, Rahman, NH, Lee, WY, Lee, FCY, Russell, SK, Lawoko, C, Al Dandachi, G, Maignan, M, Hermand, DC, Tessier, C, Roy, PM, Bucco, L, Duytsche, N, Garmilla, P, Carbone, G, Cosentini, R, Truță, S, Hrihorișan, N, Cimpoeșu, D, Rotaru, L, Petrică, A, and Cojocaru, M

Published
2020

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