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27 results on '"Chu, Tongsheng"'

1. Genome‐wide meta‐analysis and fine‐mapping prioritize potential causal variants and genes related to leprosy

Author

Wang, Zhenzhen, primary, Liu, Tingting, additional, Li, Wenchao, additional, Yu, Gongqi, additional, Mi, Zihao, additional, Wang, Chuan, additional, Liao, Xiaojie, additional, Huai, Pengcheng, additional, Chu, Tongsheng, additional, Liu, Dianchang, additional, Sun, Lele, additional, Fu, Xi'an, additional, Sun, Yonghu, additional, Wang, Honglei, additional, Wang, Na, additional, Liu, Jianjun, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2023
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2. Exploring Parallelism in Learning Belief Networks

Author

Chu, TongSheng and Xiang, Yang

Subjects
Computer Science - Artificial Intelligence, Computer Science - Learning
Abstract

It has been shown that a class of probabilistic domain models cannot be learned correctly by several existing algorithms which employ a single-link look ahead search. When a multi-link look ahead search is used, the computational complexity of the learning algorithm increases. We study how to use parallelism to tackle the increased complexity in learning such models and to speed up learning in large domains. An algorithm is proposed to decompose the learning task for parallel processing. A further task decomposition is used to balance load among processors and to increase the speed-up and efficiency. For learning from very large datasets, we present a regrouping of the available processors such that slow data access through file can be replaced by fast memory access. Our implementation in a parallel computer demonstrates the effectiveness of the algorithm., Comment: Appears in Proceedings of the Thirteenth Conference on Uncertainty in Artificial Intelligence (UAI1997)

Published
2013

3. Genome-Wide Analysis of Protein-Coding Variants in Leprosy

Author

Liu, Hong, Wang, Zhenzhen, Li, Yi, Yu, Gongqi, Fu, Xi’an, Wang, Chuan, Liu, Wenting, Yu, Yongxiang, Bao, Fangfang, Irwanto, Astrid, Liu, Jian, Chu, Tongsheng, Andiappan, Anand Kumar, Maurer-Stroh, Sebastian, Limviphuvadh, Vachiranee, Wang, Honglei, Mi, Zihao, Sun, Yonghu, Sun, Lele, Wang, Ling, Wang, Chaolong, You, Jiabao, Li, Jinghui, Foo, Jia Nee, Liany, Herty, Meah, Wee Yang, Niu, Guiye, Yue, Zhenhua, Zhao, Qing, Wang, Na, Yu, Meiwen, Yu, Wenjun, Cheng, Xiujun, Khor, Chiea Chuen, Sim, Kar Seng, Aung, Tin, Wang, Ningli, Wang, Deyun, Shi, Li, Ning, Yong, Zheng, Zhongyi, Yang, Rongde, Li, Jinlan, Yang, Jun, Yan, Liangbin, Shen, Jianping, Zhang, Guocheng, Chen, Shumin, Liu, Jianjun, and Zhang, Furen

Published
2017
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6. Prevalence, risk factors, and medical costs of Chlamydia trachomatis infections in Shandong Province, China: a population-based, cross-sectional study

Author

Huai, Pengcheng, Li, Furong, Li, Zhen, Sun, Lele, Fu, Xi’an, Pan, Qing, Yu, Gongqi, Chai, Zemin, Chu, Tongsheng, Mi, Zihao, Bao, Fangfang, Wang, Honglei, Zhou, Bingni, Wang, Chuan, Sun, Yonghu, Niu, Guiye, Zhang, Yuan, Fu, Fanghui, Lang, Xiaoqiao, Wang, Xiaoling, Zhao, Hui, Liu, Daina, Liu, Hong, Liu, Dianchang, Liu, Jian, Xu, Aiqiang, and Zhang, Furen

Published
2018
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8. The role of an active surveillance strategy of targeting household and neighborhood contacts related to leprosy cases released from treatment in a low-endemic area of China

Author

Wang, Na, primary, Chu, Tongsheng, additional, Li, Furong, additional, Wang, Zhenzhen, additional, Liu, Dianchang, additional, Chen, Mingfei, additional, Wang, Honglei, additional, Niu, Guiye, additional, Liu, Dan, additional, Zhang, Mingkai, additional, Xu, Yuanyuan, additional, Zhang, Yan, additional, Li, Jinghui, additional, Li, Zhen, additional, You, Jiabao, additional, Mao, Liguo, additional, Li, Huaizhang, additional, Chen, Yongjin, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2020
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10. Gender difference in the characteristics of and high-risk behaviours among non-injecting heterosexual methamphetamine users in Qingdao, Shandong Province, China

Author

Liu Dianchang, Wang Zhenhong, Chu Tongsheng, and Chen Shumin

Subjects
Methamphetamines, Heterosexual, High-risk behaviour, Gender, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Despite the increasing risk of HIV infections, few studies concerning the characteristics of non-injecting heterosexual methamphetamine (MA) users and related risk behaviours have been conducted in China. Methods Gender differences in socio-demographic characteristics, perception of MA and STD/HIV, MA use practices, and sexual behaviours related to MA use were examined among 398 non-injecting heterosexual MA users (288 males, 110 females). Results Male MA users were more likely to be married, local, and self-employed; female MA users were more likely to be young, single, engaged in commercial service or unemployed. Female MA users usually start MA use at an earlier age than males (24.3 vs. 31.3 years old), with shorter abuse durations (2.6 vs. 2.9 years), higher frequency of MA use (3.6 vs. 2.4 times per week), and higher likelihood of using MA with heterosexual partners (100% vs. 78.1%). More male MA users have had multiple sex partners (96.9% vs. 77.3%) and sex exchanges (72.9% vs. 46.4%). Among 277 males who had had sex with commercial sex workers (CSW), 69.4% never used condoms, and among 77 males who had had sex with multiple partners who are commercial sex workers and always or usually used condoms, 87.0% never changed condoms when changing partners. Conclusion There may be gender difference in the characteristics of high-risk behaviours among non-injecting heterosexual MA users. The findings suggest the integration of specific risk reduction strategies into intervention programs for non-injecting heterosexual MA user populations may significantly improve program goals.

Published
2013
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11. Seroprevalence and associated factors of HSV-2 infection among general population in Shandong Province, China

Author

Huai, Pengcheng, primary, Li, Furong, additional, Li, Zhen, additional, Sun, Lele, additional, Fu, Xi’an, additional, Pan, Qing, additional, Yu, Gongqi, additional, Chai, Zemin, additional, Chu, Tongsheng, additional, Mi, Zihao, additional, Bao, Fangfang, additional, Wang, Honglei, additional, Zhou, Bingni, additional, Wang, Chuan, additional, Sun, Yonghu, additional, Niu, Guiye, additional, Zhang, Yuan, additional, Fu, Fanghui, additional, Lang, Xiaoqiao, additional, Wang, Xiaoling, additional, Zhao, Hui, additional, Liu, Daina, additional, Liu, Hong, additional, Liu, Dianchang, additional, Liu, Jian, additional, Xu, Aiqiang, additional, and Zhang, Furen, additional

Published
2019
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12. Prediction of leprosy in the Chinese population based on a weighted genetic risk score

Author

Wang, Na, primary, Wang, Zhenzhen, additional, Wang, Chuan, additional, Fu, Xi'an, additional, Yu, Gongqi, additional, Yue, Zhenhua, additional, Liu, Tingting, additional, Zhang, Huimin, additional, Li, Lulu, additional, Chen, Mingfei, additional, Wang, Honglei, additional, Niu, Guiye, additional, Liu, Dan, additional, Zhang, Mingkai, additional, Xu, Yuanyuan, additional, Zhang, Yan, additional, Li, Jinghui, additional, Li, Zhen, additional, You, Jiabao, additional, Chu, Tongsheng, additional, Li, Furong, additional, Liu, Dianchang, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2018
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13. Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population

Author

Chu Tongsheng, Zhang Lin, Zhu Chuanfu, Wang Changyuan, Chen Shumin, Liu Hong, Zhang Furen, Liu Dianchang, Yan Xiaoxiao, and Liu Jianjun

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to Mycobacterium leprae. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population. Methods The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals. Results The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease. Conclusion HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.

Published
2009
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14. Evaluation of ProspectiveHLA-B*13:01Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy

Author

Liu, Hong, Wang, Zhenzhen, Bao, Fangfang, Wang, Chuan, Sun, Lele, Zhang, Huimin, Yu, Gongqi, Mi, Zihao, Li, Jianke, Li, Lulu, Zhao, Qing, Yue, Zhenhua, Zhao, Wei, Yu, Wenjun, Cao, Jing, Xiong, Fei, Wang, Yaru, Chai, Zemin, Cheng, Xiujun, Zhang, Yuan, Fu, Fanghui, Lang, Xiaoqiao, Wang, Xiaoling, Irwanto, Astrid, Krismawati, Hana, Fu, Xi’an, Sun, Yonghu, You, Jiabao, Liu, Jian, Pan, Qing, Chu, Tongsheng, Liu, Dianchang, Chen, Shumin, Shen, Jianping, Yan, Liangbin, Zhang, Guocheng, Liu, Jianjun, Zhang, Furen, Xiong, Li, Yang, Jun, Li, Jinlan, Ke, Wei, Li, Ming, Ning, Yong, Xiong, Junhao, Xiong, Mingzhou, Yang, Bin, Duan, Qizhi, Wang, Hong, Li, Wei, Kuang, Yanfei, Li, Junhua, Wang, Lamei, Cao, Qiuyang, Xiao, Peng, Xiao, Bangzhong, Zhang, Lianhua, Lin, Zhaoxing, Wang, Yaofei, Shen, Yunliang, Yan, Liying, Wu, Wenbin, Zheng, Hu, Zhan, Xianfa, Li, Wanghua, Shang, Xiujian, Xu, Yujun, and Liu, Qiao

Subjects
medicine.medical_specialty, business.industry, Standard treatment, Incidence (epidemiology), Dermatology, Dapsone, medicine.disease, Clofazimine, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, Leprosy, Prospective cohort study, Adverse effect, business, Rifampicin, Original Investigation, medicine.drug
Abstract

IMPORTANCE: Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine. Although the HLA-B*13:01 polymorphism has been identified as the genetic determinant of DHS in the Chinese population, no studies to date have been done to evaluate whether prospective HLA-B*13:01 screening could prevent DHS by identifying patients who should not receive dapsone. OBJECTIVE: To evaluate the clinical use of prospective HLA-B*13:01 screening for reduction of the incidence of DHS by excluding dapsone from the treatment for patients with HLA-B*13:01–positive leprosy. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted from February 15, 2015, to April 30, 2018, in 21 provinces throughout China. A total of 1539 patients with newly diagnosed leprosy were enrolled who had not received dapsone previously. After excluding patients who had a history of allergy to sulfones or glucose-6-phosphate dehydrogenase deficiency, 1512 individuals underwent HLA-B*13:01 genotyping. All of the patients were followed up weekly for the first 8 weeks after treatment to monitor for adverse events. EXPOSURES: Patients who were HLA-B*13:01 carriers were instructed to eliminate dapsone from their treatment regimens, and noncarrier patients received standard MDT. MAIN OUTCOMES AND MEASURES: The primary outcome was the incidence of DHS. The historical incidence rate of DHS (1.0%) was used as a control. RESULTS: Among 1512 patients (1026 [67.9%] men, 486 [32.1%] women; mean [SD] age, 43.1 [16.2] years), 261 (17.3%) were identified as carriers of the HLA-B*13:01 allele. A total of 714 adverse events in 384 patients were observed during the follow-up period. Dapsone hypersensitivity syndrome did not develop in any of the 1251 patients who were HLA-B*13:01–negative who received dapsone, while approximately 13 patients would be expected to experience DHS, based on the historical incidence rate of 1.0% per year (P = 2.05 × 10(−5)). No significant correlation was found between other adverse events, including dermatologic or other events, and HLA-B*13:01 status. CONCLUSIONS AND RELEVANCE: Prospective HLA-B*13:01 screening and subsequent elimination of dapsone from MDT for patients with HLA-B*13:01–positive leprosy may significantly reduce the incidence of DHS in the Chinese population.

Published
2019

15. The syphilis epidemic in Shandong province, China: An analysis based on surveillance data from 2004 to 2011

Author

Liu, Dianchang, Chu, Tongsheng, and Chen, Shumin

Subjects
Epidemics -- Analysis -- Usage -- China, Syphilis -- Analysis -- Diagnosis -- Distribution -- Research, Company distribution practices, Health
Abstract

Byline: Dianchang. Liu, Tongsheng. Chu, Shumin. Chen Sir, Since syphilis re-emerged in China in the 1970s, the disease has been spreading widely over the country, with an accelerating speed. [sup][1] [...]

Published
2013

20. Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases

Author

Liu, Hong, primary, Irwanto, Astrid, additional, Tian, Hongqing, additional, Fu, Xi'an, additional, Yu, Yongxiang, additional, Yu, Gongqi, additional, Low, Huiqi, additional, Chu, Tongsheng, additional, Li, Yi, additional, Shi, Benqing, additional, Chen, Mingfei, additional, Sun, Yonghu, additional, Yuan, Chunying, additional, Lu, Nan, additional, You, Jiabao, additional, Bao, Fangfang, additional, Li, Jinghui, additional, Liu, Jian, additional, Liu, Huaxu, additional, Liu, Dianchang, additional, Yu, Xiulu, additional, Zhang, Lin, additional, Yang, Qing, additional, Wang, Na, additional, Niu, Guiye, additional, Ma, Shanshan, additional, Zhou, Yan, additional, Wang, Chuan, additional, Chen, Shumin, additional, Zhang, Xuejun, additional, Liu, Jianjun, additional, and Zhang, Furen, additional

Published
2012
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26. Association study of the single nucleotide polymorphisms of PARK2 and PACRG with leprosy susceptibility in Chinese population.

Author

Li, Jinghui, Liu, Hong, Liu, Jian, Fu, Xi'an, Yu, Yongxiang, Yu, Gongqi, Chen, Shumin, Chu, Tongsheng, Lu, Nan, Bao, Fangfang, Yuan, Chunying, and Zhang, Furen

Subjects
HANSEN'S disease, SINGLE nucleotide polymorphisms, HETEROGENEITY, CHINESE people, POPULATION genetics
Abstract

The article focuses on the Genome-Wide Association Study of single nucleotide polymorphisms (SNP) of association of PARK2 and PACRG with leprosy in Chinese population. The study found no remarkable association of Chinese population with the risk SNPs within the PARK2 and PACRG leprosy region. It is noted that there may be a suggestive association of SNPs with ethnic heterogeneity of susceptibility to leprosy.

Published
2012
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