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Background Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) have been met. Methodology/Principal findings A cross-sectional study was conducted from September 2016 to January 2017. Participants were 5- to 9-year-old school children. Onchocerciasis/lymphatic Filariasis (LF, only in endemic districts) rapid diagnostic tests (RDTs) were performed. Blood spots were collected from RDT positive children and 10 percent of the RDT negatives to determine Ov16 and Wb123 IgG4 antibodies through enzyme-linked immunosorbent assay (ELISA). Skin snips were collected from RDT positives. Filarial detection was performed by PCR in positives and indeterminate sera. Black fly collection was carried out in traditional breeding sites. A total of 7,052 children, ranging from 5 to 9 years of age, were included in the study. Four children (0.06%) were Ov16 IgG4 RDT positives, but negative by ELISA Ov16, while 6 RDT negative children tested positive by ELISA. A total of 1,230 children from the Riaba and Baney districts were tested for LF. One child was Wb123 RDT positive (0.08%), but ELISA negative, while 3 RDT negative children were positive by Wb123 ELISA. All positive samples were negative by PCR for onchocerciasis and LF (in blood spot and skin snip). All fly collections and larval prospections in the traditional catching and prospection sites were negative. Conclusions/Significance WHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection., Author summary Onchocerciasis, commonly called river blindness, is a chronic parasitic disease particularly prevalent in Africa. It is transmitted through the bites of infected Simulium blackflies. Onchocerciasis is endemic in Equatorial Guinea. Huge achievements have been made in human and vector control during the last two decades, especially on Bioko Island. Eliminating onchocerciasis transmission on Bioko is feasible given its isolation from other landmasses, which also reduces the risk of reinvasion by the disease vector. Recently updated WHO guidelines for stopping mass drug administration (MDA) and verifying elimination of human onchocerciasis (2016) established a new critical threshold to verify elimination of onchocerciasis transmission based on novel serological tests. We applied these techniques in a representative sample of 5- to 9-year-old school children. An entomological assessment was also carried out. We found no evidence of current infection or recent transmission. There was no evidence of onchocerciasis vectors, and our results from the sample population meet the current WHO serologic criteria for stopping MDA. Based on these results, we recommended to the Ministry of Health and Social Welfare of Equatorial Guinea that MDA on Bioko Island be stopped and that 3 years of post-treatment surveillance should be undertaken to identify any new occurrences of exposure or infection.

OBJECTIVE: The measurement of patient satisfaction is considered an essential outcome indicator to evaluate health care quality. Patient satisfaction is considered a multi-dimensional construct, which would include a variety of domains. Although a large number of studies have proposed scales to measure patient satisfaction, there is a lack of psychometric information on them. This study aims to describe the psychometric properties of the Primary Care Satisfaction Scale (PCSS) of the EUprimecare project. DESIGN: A cross-sectional survey of patient satisfaction with primary care was carried out by telephone interview. SETTING: Primary care services of Estonia, Finland, Germany, Hungary, Lithuania, Italy and Spain. PARTICIPANTS: A total of 3020 adult patients aged 18-65 years old attending primary care services. METHOD: Classic psychometric properties were analysed and Rasch analysis was used to assess the following measurement properties: fit to the Rasch model; uni-dimensionality; reliability; differential item functioning (DIF) by gender, age, civil status, area of residency and country; local independency; adequacy of response scale; and scale targeting. RESULTS: To achieve good fit to the Rasch model, the original response scales of three items (1, 2 and 6) were rescored and Item 3 (waiting time in the room) was removed. The scale was uni-dimensional and Person Separation Index was 0.79, indicating a good reliability. All items were free from bias. PCSS linear measure displayed satisfactory convergent validity with overall satisfaction with primary care. CONCLUSIONS: PCSS, as a reliable and valid scale, could be used to measure patient satisfaction in primary care in Europe. This work was supported by EUprimecare project that was funded under the European Commission's 7th Framework Programme (grant no. 241595).