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Background: The use of 18 F-FDG Positron emission tomography/Computed tomography (PET/CT) in the initial staging of many cancers is clearly established. Most soft tissue sarcoma (STS) has a high affinity for 18 F-FDG, which is why 18 F-FDG PET/CT has been proposed as a non-invasive method, useful in diagnosis and follow-up. The standardized uptake value values (SUV), the volume-based metabolic parameters MTV (metabolic tumor volume), and TLG (total lesion glycolysis) determine tumor viability and provide its total volume and the total activity of metabolically active tumor cells. The histological grade is the most important predictor of metastases and mortality associated with STS, and a significant relationship between the metabolic parameters of 18 F-FDG PET/CT and the histological grade has been described., Methods: A retrospective study was conducted on STS patients, who had histological grade according to the FNCLCC (Fédération Nationale des Centres de Lutte Contre Le Cancer) criteria, as well as a baseline PET/CT. SUV (SUV max , SUV mean , and SUV peak ), MTV, and TLG were quantified. A T-student test was performed to establish the relationship between the metabolic biomarkers and the histological grade. Their usefulness as predictors of the histological grade was verified using receiver operator characteristic (ROC) curves. A survival function study was performed using the Kaplan-Meier method. To assess the prognostic utility of the metabolic biomarkers we use the Log-Rank method., Results: The SUV values were useful to discriminate high-grade STS. We found a significant relationship between the histological grade and the SUV values. SUV max , SUV peak , MTV, and TLG were predictors of overall survival (OS). There were no significant differences in the OS for the SUV mean , or in the disease-free survival (DFS) for SUV max , SUV mean , SUV peak , MTV, and TLG., Conclusions: The SUV max , SUV mean , and SUV peak values correlate with the HG and are useful to discriminate high-grade from low-grade STS. Patients with high SUV max , SUV peak , MTV, and TLG have a significantly lower OS., (© 2021. The Author(s).)