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2. [Myocardial ischemia without coronary obstructions: MINOCA-INOCA. Review for decision making]

Author

Cohen Arazi, H, Iglesias, R, Duronto, E, Lescano, A, Campisi, R, Deviggiano, A, Caroli, C, Nani, S, Mariani, J, Comtesse, D, Zanotti, S, Kaski, JC, and GREECO (Grupo de Estudio de Enfermedades Coronarias)

Abstract

One in every four coronarographies performed to study myocardial ischemia shows coronary angiographic stenosis less than 50%. This data triggered an increasing interest in the medical community. The American Society of Cardiology recently published a position paper about the pathophysiology, diagnosis and treatment of this entity. Our group performed a narrative review reflecting the opinion of cardiology experts from different centers in Argentina. It aims physiopatologic and diagnostic aspect to understand the current approach in patients with MINOCA (myocardial infarction with non-obstructive coronary arteries) e INOCA (demonstrated angina and ischemia but without coronary lesions that justify this syndrome).

Published
2020

3. [Vitamin D deficiency is associated with cardiovascular risk factors in a healthy population].

Author

Seropian IM, Perez Soriano ML, Kriemer H, Valdizan M, Seijo M, and Cohen Arazi H

Subjects
Adult, Age Factors, Blood Pressure physiology, Cholesterol, HDL blood, Female, Humans, Hypertriglyceridemia blood, Male, Middle Aged, Motor Activity physiology, Obesity blood, Prospective Studies, Risk Factors, Sex Factors, Vitamin D Deficiency blood, Vitamin D Deficiency epidemiology, Cardiovascular Diseases complications, Vitamin D Deficiency complications
Abstract

Vitamin D (VitD) deficiency is associated with increased morbidity and mortality. We evaluated the association of VitD deficiency (<50 mmol/l) and cardiovascular risk factors in a healthy population, from July-November 2012, in a private center at Buenos Aires province. 333 people were included, aged 41.6±12.4 years (58.6% men), 49.2% practiced no physical activity, 56.8% were overweight (70.3% man vs 37.7% women, p<0.001), 12.5% with systolic blood pressure (SBP) >140 mmHg and 6% diastolic blood pressure (DBP) >90 mmHg. VitD deficiency was observed in 29.1% (31.3% man vs 26.1% women, p=0.3), more frequent with obesity (OR 1.85, IC95:1.05-3.25, p=0.02), HDL-cholesterol (HDL-C)<50 mg/dl (OR 1.71, IC95:1.06-2.76, p=0.02) and triglycerides>150 mg/dl (OR 1.77, IC95:1.02-3.06, p=0.03). A trend towards VitD deficiency and SBP>140 mmHg (OR 1.88, IC95:0.93-3.77, p=0.07) or DBP>90 mmHg (OR 1.39, IC95:0.5-3.65, p=0.5) was observed. Lineal correlation between VitD and HDL-C (p<0.001) or triglycerides (p<0.001) was observed. Multiple logistic regression showed that VitD deficiency association with low HDL-C was independent of age, female sex, obesity and physical activity. Association of VitD deficiency with hypetriglyceridemia was independent of age, female sex and obesity. This study shows an association between VitD deficiency and cardiovascular risk factors like obesity, low HDL <50 mg/dl and hypertriglyceridemia. A trend toward higher SBP was also observed. Experimental studies are granted in order to establish a cause-effect relationship.

Published
2013

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