48 results on '"Competitive Model"'
Search Results
2. A time-resolved fluorescence microsphere-lateral flow immunochromatographic strip for quantitative detection of Pregnanediol-3-glucuronide in urine samples
- Author
-
Jiasheng Lin, Sanhua Li, Benchen Ye, Weigang Zheng, Huihui Wang, Ying Liu, Dong Wang, Zaihui Wu, Wen-Fei Dong, and Minghui Zan
- Subjects
time-resolved fluorescence microspheres ,Pregnanediol-3-glucuronide ,lateral flow immunochromatographic ,urine sample ,competitive model ,Biotechnology ,TP248.13-248.65 - Abstract
Introduction: Pregnanediol-3-glucuronide (PdG), as the main metabolite of progesterone in urine, plays a significant role in the prediction of ovulation, threatened abortion, and menstrual cycle maintenance.Methods: To achieve a rapid and sensitive assay, we have designed a competitive model-based time-resolved fluorescence microsphere-lateral flow immunochromatography (TRFM-LFIA) strip.Results: The optimized TRFM-LFIA strip exhibited a wonderful response to PdG over the range of 30–2,000 ng/mL, the corresponding limit of detection (LOD) was calculated as low as 8.39 ng/mL. More importantly, the TRFM-LFIA strip was innovatively used for the quantitative detection of PdG in urine sample, and excellent recovery results were also obtained, ranging from 97.39% to 112.64%.Discussion: The TRFMLFIA strip possessed robust sensitivity and selectivity in the determination of PdG, indicating the great potential of being powerful tools in the biomedical and diagnosis region.
- Published
- 2023
- Full Text
- View/download PDF
3. Exploration on dynamics in a discrete predator–prey competitive model involving feedback controls
- Author
-
Changjin Xu, Xiaohan Cui, Peiluan Li, Jinling Yan, and Lingyun Yao
- Subjects
Competitive model ,permanence ,feedback control ,delay ,global attractivity ,34K20 ,Environmental sciences ,GE1-350 ,Biology (General) ,QH301-705.5 - Abstract
In this work, we set up a new discrete predator–prey competitive model with time-varying delays and feedback controls. By virtue of the difference inequality knowledge, a sufficient condition which guarantees the permanence of the established discrete predator–prey competitive model with time-varying delays and feedback controls is derived. Under some appropriate parameter conditions, we have proved that the periodic solution of the system without delay exists and globally attractive. To verify the correctness of the derived theoretical fruits, we give two examples and execute computer simulations. Our obtained results are novel and complement previous known results.
- Published
- 2023
- Full Text
- View/download PDF
4. Monotonicity properties arising in a simple model of Wolbachia invasion for wild mosquito populations
- Author
-
Diego Vicencio, Olga Vasilieva, and Pedro Gajardo
- Subjects
wolbachia symbiont ,monotone dynamics ,competitive model ,minimum viable population size ,Biotechnology ,TP248.13-248.65 ,Mathematics ,QA1-939 - Abstract
In this paper, we propose a simplified bidimensional Wolbachia infestation model in a population of Aedes aegypti mosquitoes, preserving the main features associated with the biology of this species that can be found in higher-dimensional models. Namely, our model represents the maternal transmission of the Wolbachia symbiont, expresses the reproductive phenotype of cytoplasmic incompatibility, accounts for different fecundities and mortalities of infected and wild insects, and exhibits the bistable nature leading to the so-called principle of competitive exclusion. Using tools borrowed from monotone dynamical system theory, in the proposed model, we prove the existence of an invariant threshold manifold that allows us to provide practical recommendations for performing single and periodic releases of Wolbachia-carrying mosquitoes, seeking the eventual elimination of wild insects that are capable of transmitting infections to humans. We illustrate these findings with numerical simulations using parameter values corresponding to the wMelPop strain of Wolbachia that is considered the best virus blocker but induces fitness loss in its carriers. In these tests, we considered multiple scenarios contrasting a periodic release strategy against a strategy with a single inundative release, comparing their effectiveness. Our study is presented as an expository and mathematically accessible tool to study the use of Wolbachia-based biocontrol versus more complex models.
- Published
- 2023
- Full Text
- View/download PDF
5. DEVELOPING A COMPETITIVE MODEL FOR HEALTH AND WELL-BEING TOURISM DESTINATIONS IN THAILAND: CONFIRMATORY FACTOR ANALYSIS APPROACH
- Author
-
Thadathibesra PHUTHONG
- Subjects
competitive model ,health destination ,well-being destination ,health tourism ,confirmatory factor analysis ,Geography. Anthropology. Recreation ,Geography (General) ,G1-922 - Abstract
This study assesses the consistency of the structural components of a model for developing a competitive health and well-being destination as viewed by health and well-being tourism entrepreneurs in an emerging Thai market. The sample consisted of 216 health and well-being tourism entrepreneurs recruited by purposive sampling. A questionnaire formatted using a five-point Likert scale was used. The questionnaire’s Index of Item-Objective Congruence (IOC) varied from 0.60 to 1.00, and its reliability ranged from 0.711 to 0.938. Statistical analysis, frequencies, percentages, means, standard deviations, exploratory factor analysis and confirmatory factor analysis were utilised. The findings revealed the following seven model components: 1) health and well-being tourism resources and attractions, 2) infrastructure and facilities, 3) service design and development, 4) policy, planning and destination management, 5) knowledge management and learning organisation, 6) destination management and 7) innovative capacity. Governors, entrepreneurs, destination managers and stakeholders can use the discovered variables to evaluate a competitive health and well-being destination’s expected performance, strengths, weaknesses and development opportunities. Further, this research should enable continuing support through the critical variable factors.
- Published
- 2021
- Full Text
- View/download PDF
6. Dynamics and Bifurcations in Filippov Type of Competitive and Symbiosis Systems.
- Author
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Cao, Nanbin, Zhang, Yue, and Liu, Xia
- Subjects
- *
SYMBIOSIS , *LINEAR systems , *HARVESTING , *COMPUTER simulation - Abstract
Filippov systems have found applications in various fields. This paper mainly studies five Lotka–Volterra models of Filippov type, including a competitive system with linear interaction between two species, a competitive system with Holling type II or type III functional response and a symbiosis system with Holling type II or type III functional response. We investigate the stability of all equilibria and the boundary equilibrium bifurcations of these systems, either a persistence bifurcation or a nonsmooth fold bifurcation. We present the numerical simulation results for each case. Consequently, based on both theory and simulation, we analyze the ecological aspects under the intervention of harvesting at different prescribed thresholds. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
7. Optimal harvesting strategies of a stochastic competitive model with S-type distributed time delays and Lévy jumps
- Author
-
Hong Qiu, Wenmin Deng, and Mingqi Xiang
- Subjects
Optimal harvesting ,Competitive model ,White noise ,S-type distributed time delays ,Lévy jumps ,Stability in distribution ,Analysis ,QA299.6-433 - Abstract
Abstract The aim of this paper is to investigate the optimal harvesting strategies of a stochastic competitive Lotka–Volterra model with S-type distributed time delays and Lévy jumps by using ergodic method. Firstly, the sufficient conditions for extinction and stable in the time average of each species are established under some suitable assumptions. Secondly, under a technical assumption, the stability in distribution of this model is proved. Then the sufficient and necessary criteria for the existence of optimal harvesting policy are established under the condition that all species are persistent. Moreover, the explicit expression of the optimal harvesting effort and the maximum of sustainable yield are given.
- Published
- 2021
- Full Text
- View/download PDF
8. Stability and Hopf bifurcation for a delayed diffusive competition model with saturation effect
- Author
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Changyong Xu, Qiang Li, Tonghua Zhang, and Sanling Yuan
- Subjects
competitive model ,time delay ,diffusion ,stability ,hopf bifurcation ,Biotechnology ,TP248.13-248.65 ,Mathematics ,QA1-939 - Abstract
This paper presents an investigation on the dynamics of a delayed diffusive competition model with saturation effect. We first perform the stability analysis of the positive equilibrium and the existence of Hopf bifurcations. It is shown that the positive equilibrium is asymptotically stable under some conditions, and that there exists a critical value of delay, when the delay increases across it, the positive equilibrium loses its stability and a spatially homogeneous or inhomogeneous periodic solution emerges from the positive equilibrium. Then, we derive the formulas for the determination of the direction of Hopf bifurcation and the properties of the bifurcating periodic solutions. Finally, some numerical simulations are performed to illustrate the obtained results.
- Published
- 2020
- Full Text
- View/download PDF
9. Dynamics of a diffusive competitive model on a periodically evolving domain
- Author
-
Jiazhen Zhu, Jiazheng Zhou, and Zhigui Lin
- Subjects
competitive model ,diffusion ,evolving domain ,ecological reproduction indexes ,Mathematics ,QA1-939 - Abstract
This article concerns a two-species competitive model with diffusive terms in a periodically evolving domain and study the impact of the spatial periodic evolution on the dynamics of the model. The Lagrangian transformation approach is adopted to convert the model from a changing domain to a fixed domain with the assumption that the evolution of habitat is uniform and isotropic. The ecological reproduction indexes of the linearized model are given as thresholds to reveal the dynamic behavior of the competitive model. Our theoretical results show that a lager evolving rate benefits the persistence of competitive populations for both sides in the long run. Numerical experiments illustrate that two competitive species, one of which survive and the other vanish in a fixed domain, both survive in a domain with a large evolving rate, and both vanish in a domain with a small evolving rate.
- Published
- 2020
10. Dynamics of two-species delayed competitive stage-structured model described by differential-difference equations
- Author
-
Han Sufang, Li Yaqin, Liu Guoxin, Xiong Lianglin, and Zhang Tianwei
- Subjects
stage structure ,almost periodic solution ,coincidence degree ,competitive model ,stability ,34k13 ,34k20 ,92b05 ,92d25 ,Mathematics ,QA1-939 - Abstract
Overf the last few years, by utilizing Mawhin’s continuation theorem of coincidence degree theory and Lyapunov functional, many scholars have been concerned with the global asymptotical stability of positive periodic solutions for the non-linear ecosystems. In the real world, almost periodicity is usually more realistic and more general than periodicity, but there are scarcely any papers concerning the issue of the global asymptotical stability of positive almost periodic solutions of non-linear ecosystems. In this paper we consider a kind of delayed two-species competitive model with stage structure. By means of Mawhin’s continuation theorem of coincidence degree theory, some sufficient conditions are obtained for the existence of at least one positive almost periodic solutions for the above model with nonnegative coefficients. Furthermore, the global asymptotical stability of positive almost periodic solution of the model is also studied. The work of this paper extends and improves some results in recent years. An example and simulations are employed to illustrate the main results of this paper.
- Published
- 2019
- Full Text
- View/download PDF
11. Optimal harvesting strategies of a stochastic competitive model with S-type distributed time delays and Lévy jumps.
- Author
-
Qiu, Hong, Deng, Wenmin, and Xiang, Mingqi
- Subjects
- *
HARVESTING , *STOCHASTIC models , *OIL & fat extraction , *WHITE noise - Abstract
The aim of this paper is to investigate the optimal harvesting strategies of a stochastic competitive Lotka–Volterra model with S-type distributed time delays and Lévy jumps by using ergodic method. Firstly, the sufficient conditions for extinction and stable in the time average of each species are established under some suitable assumptions. Secondly, under a technical assumption, the stability in distribution of this model is proved. Then the sufficient and necessary criteria for the existence of optimal harvesting policy are established under the condition that all species are persistent. Moreover, the explicit expression of the optimal harvesting effort and the maximum of sustainable yield are given. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
12. Planning of multi-hub energy system by considering competition issue.
- Author
-
Farshidian, Behzad, Rajabi-Ghahnavieh, Abbas, and Haghi, Ehsan
- Subjects
ENERGY industries ,ELECTRIC power transmission ,ELECTRICITY ,ENERGY storage ,ECONOMIC competition - Abstract
Energy hub concept has been emerged as a suitable tool to analyze multi-carrier energy systems. Deregulation and increasing competition in the energy industry have provided a suitable platform for developing the multi-agent energy systems. Planning of energy hubs considering the competition between the hubs has not been sufficiently addressed, yet. A model has been proposed in this study for planning of a multi-hub energy system considering the competition between the hubs. The hubs are interconnected via an electric transmission system. A linear model has been developed to determine the optimal planning/operation strategy for energy hubs in a multi-period planning horizon to meet the heat and electricity demand for the defined load zone. The problem has been formulated and solved using Karush-Kuhn-Tucker (KKT) conditions. The proposed model has been applied to 3-Hub and 5-Hub energy systems. The effect of renewable generation and storage system has also been evaluatedIt has also been observed that inclusion of renewable generation or storage technologies can reduce the conventional electricity generation capacity by 63 percent in HUB2. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
13. A Discrete Competitive Facility Location Model with Minimal Market Share Constraints and Equity-Based Ties Breaking Rule.
- Author
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FERNÁNDEZ, Pascual, LANČINSKAS, Algirdas, PELEGRÍN, Blas, and ŽILINSKAS, Julius
- Subjects
- *
MARKET share , *HEURISTIC algorithms , *FACILITY location problems , *MARKETING models - Abstract
Abstract. We consider a geographical region with spatially separated customers, whose demand is currently served by some pre-existing facilities owned by different firms. An entering firm wants to compete for this market locating some new facilities. Trying to guarantee a future satisfactory captured demand for each new facility, the firm imposes a constraint over its possible locations (a finite set of candidates): a new facility will be opened only if a minimal market share is captured in the short-term. To check that, it is necessary to know the exact captured demand by each new facility. It is supposed that customers follow the partially binary choice rule to satisfy its demand. If there are several new facilities with maximal attraction for a customer, we consider that the proportion of demand captured by the entering firm will be equally distributed among such facilities (equity-based rule). This ties breaking rule involves that we will deal with a nonlinear constrained discrete competitive facility location problem. Moreover, minimal attraction conditions for customers and distances approximated by intervals have been incorporated to deal with a more realistic model. To solve this nonlinear model, we first linearize the model, which allows to solve small size problems because of its complexity, and then, for bigger size problems, a heuristic algorithm is proposed, which could also be used to solve other constrained problems. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
14. Dynamical behavior for a stochastic two-species competitive model
- Author
-
Xu Changjin and Liao Maoxin
- Subjects
competitive model ,global stability ,stochastic perturbation ,60h30 ,60h10 ,92d25 ,Mathematics ,QA1-939 - Abstract
This paper deals with a stochastic two-species competitive model. Some very verifiable criteria on the global stability of the positive equilibrium of the deterministic system are established. An example with its computer simulations is given to illustrate our main theoretical findings.
- Published
- 2017
- Full Text
- View/download PDF
15. Discrete Competitive Lotka–Volterra Model with Controllable Phase Volume
- Author
-
Anzhelika Voroshilova and Jeff Wafubwa
- Subjects
Lotka–Volterra ,competitive model ,adaptive discrete maps ,discrete nonlinear systems ,reproductive behavior simulation ,stable marital problem ,Systems engineering ,TA168 ,Technology (General) ,T1-995 - Abstract
The simulation of population dynamics and social processes is of great interest in nonlinear systems. Recently, many scholars have paid attention to the possible applications of population dynamics models, such as the competitive Lotka–Volterra equation, in economic, demographic and social sciences. It was found that these models can describe some complex behavioral phenomena such as marital behavior, the stable marriage problem and other demographic processes, possessing chaotic dynamics under certain conditions. However, the introduction of external factors directly into the continuous system can influence its dynamic properties and requires a reformulation of the whole model. Nowadays most of the simulations are performed on digital computers. Thus, it is possible to use special numerical techniques and discrete effects to introduce additional features to the digital models of continuous systems. In this paper we propose a discrete model with controllable phase-space volume based on the competitive Lotka–Volterra equations. This model is obtained through the application of semi-implicit numerical methods with controllable symmetry to the continuous competitive Lotka–Volterra model. The proposed model provides almost linear control of the phase-space volume and, consequently, the quantitative characteristics of simulated behavior, by shifting the symmetry of the underlying finite-difference scheme. We explicitly show the possibility of introducing almost arbitrary law to control the phase-space volume and entropy of the system. The proposed approach is verified through bifurcation, time domain and phase-space volume analysis. Several possible applications of the developed model to the social and demographic problems’ simulation are discussed. The developed discrete model can be broadly used in modern behavioral, demographic and social studies.
- Published
- 2020
- Full Text
- View/download PDF
16. A time-resolved fluorescence microsphere-lateral flow immunochromatographic strip for quantitative detection of Pregnanediol-3-glucuronide in urine samples.
- Author
-
Lin J, Li S, Ye B, Zheng W, Wang H, Liu Y, Wang D, Wu Z, Dong WF, and Zan M
- Abstract
Introduction: Pregnanediol-3-glucuronide (PdG), as the main metabolite of progesterone in urine, plays a significant role in the prediction of ovulation, threatened abortion, and menstrual cycle maintenance. Methods: To achieve a rapid and sensitive assay, we have designed a competitive model-based time-resolved fluorescence microsphere-lateral flow immunochromatography (TRFM-LFIA) strip. Results: The optimized TRFM-LFIA strip exhibited a wonderful response to PdG over the range of 30-2,000 ng/mL, the corresponding limit of detection (LOD) was calculated as low as 8.39 ng/mL. More importantly, the TRFM-LFIA strip was innovatively used for the quantitative detection of PdG in urine sample, and excellent recovery results were also obtained, ranging from 97.39% to 112.64%. Discussion: The TRFMLFIA strip possessed robust sensitivity and selectivity in the determination of PdG, indicating the great potential of being powerful tools in the biomedical and diagnosis region., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Lin, Li, Ye, Zheng, Wang, Liu, Wang, Wu, Dong and Zan.)
- Published
- 2023
- Full Text
- View/download PDF
17. A liner shipping competitive model with consideration of service quality management.
- Author
-
Han, Shuihua, Cao, Bin, Fu, Yufang, and Luo, Zongwei
- Subjects
- *
MARITIME shipping , *QUALITY of service , *BIG data , *DATA analytics , *SUPPLY chain management - Abstract
Under current competitive liner shipping market, it is crucial to explore the optimal shipping strategy for the subsistence and development of liner companies. In order to establish a liner shipping competitive model, we choose service quality, which can be measured by a range of unstructured data of relative items (such as delivery service, security, processing speed, user-friendliness) with big data analytics, as a key factor in the utility function and analyze the impact of service quality on the pricing strategy for container liner shipping context. By using the analytic hierarchy process, fuzzy comprehensive evaluation and time series forecasting method, the concrete data from South America container liner shipping market is analyzed via empirical study. The finding has demonstrated the model could yield management value for liner companies, and could provide theoretical guidance to formulate the optimal liner shipping strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
18. Competetive potential in the regional management
- Author
-
Olga Vladimirovna Komelina and Vita Vladimirovna Rzhepishevskaya
- Subjects
region ,competitive potential ,competitive model ,competitive advantages ,competitiveness ,structure ,assessment ,monitoring ,regional management ,Regional economics. Space in economics ,HT388 - Abstract
Modern regional management needs special regional policy aimed at making the competitive potential of the region as a factor of its sustainable development. In this regard, the main task of this study is to base the nature, structure and destination of competitive potential for regional management, as well as the development of its grade methodology. It is proposed to consider the competitive potential of the region as a set of available resources, tools, and sources of various properties, which belong to the territory and which help to attract attention of aimed customers (investors, entrepreneurs, residents, tourists, etc.) at it, increase of the demand for some of its elements, which can be used in competition, making unique resources and capabilities into competitive advantages. Along with the traditional elements of the competitive potential of the region some elements were offered to include in its structure. Those elements show modern organizational and economic relations of the regional productive forces. The assessing technique of the competitive potential level of the region was developed. One of its most important areas of practical use the results are the organization of the formation potential monitoring for local, regional, and national governance.
- Published
- 2014
- Full Text
- View/download PDF
19. The effect of Lévy noise on the survival of a stochastic competitive model in an impulsive polluted environment.
- Author
-
Zhao, Yu, Yuan, Sanling, and Zhang, Qimin
- Subjects
- *
POLLUTION , *SOUND , *ECOLOGY , *CONSCIENTIOUSNESS ,PERSISTENCE - Abstract
Lévy noise, accounting for sudden catastrophic shocks, exists widely in the natural world. However, the effect of Lévy noise on the survival of a population is not well understood. In this paper, we develop and investigate a stochastic competitive model of two species with Lévy noise in an impulsive polluted environment. The threshold between weak persistence in the mean and extinction is established for each species. Sufficient conditions for strong persistence in the mean, stability in the mean and stochastic permanence are obtained. These results show that Lévy noise can change the persistence and extinction of each species significantly. Numerical simulations is carried out to illustrate the theoretical results. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
20. A Discrete Competitive Facility Location Model with Minimal Market Share Constraints and Equity-Based Ties Breaking Rule
- Author
-
Julius Žilinskas, Pascual Fernández, Algirdas Lančinskas, and Blas Pelegrín
- Subjects
Microeconomics ,Location ,Competitive model ,Heuristic algorithms ,Applied Mathematics ,Equity (finance) ,Business ,Market share ,Facility location problem ,Information Systems - Abstract
We consider a geographical region with spatially separated customers, whose demand is currently served by some pre-existing facilities owned by different firms. An entering firm wants to compete for this market locating some new facilities. Trying to guarantee a future satisfactory captured demand for each new facility, the firm imposes a constraint over its possible locations (a finite set of candidates): a new facility will be opened only if a minimal market share is captured in the short-term. To check that, it is necessary to know the exact captured demand by each new facility. It is supposed that customers follow the partially binary choice rule to satisfy its demand. If there are several new facilities with maximal attraction for a customer, we consider that the proportion of demand captured by the entering firm will be equally distributed among such facilities (equity-based rule). This ties breaking rule involves that we will deal with a nonlinear constrained discrete competitive facility location problem. Moreover, minimal attraction conditions for customers and distances approximated by intervals have been incorporated to deal with a more realistic model. To solve this nonlinear model, we first linearize the model, which allows to solve small size problems because of its complexity, and then, for bigger size problems, a heuristic algorithm is proposed, which could also be used to solve other constrained problems.
- Published
- 2020
- Full Text
- View/download PDF
21. Dynamics of two-species delayed competitive stage-structured model described by differential-difference equations
- Author
-
Guoxin Liu, Sufang Han, Yaqin Li, Lianglin Xiong, and Tianwei Zhang
- Subjects
lcsh:Mathematics ,General Mathematics ,010102 general mathematics ,Dynamics (mechanics) ,almost periodic solution ,Differential difference equations ,34k20 ,stability ,92b05 ,92d25 ,lcsh:QA1-939 ,stage structure ,01 natural sciences ,coincidence degree ,010101 applied mathematics ,34k13 ,competitive model ,Applied mathematics ,Stage (hydrology) ,0101 mathematics ,Structured model ,Mathematics - Abstract
Overf the last few years, by utilizing Mawhin’s continuation theorem of coincidence degree theory and Lyapunov functional, many scholars have been concerned with the global asymptotical stability of positive periodic solutions for the non-linear ecosystems. In the real world, almost periodicity is usually more realistic and more general than periodicity, but there are scarcely any papers concerning the issue of the global asymptotical stability of positive almost periodic solutions of non-linear ecosystems. In this paper we consider a kind of delayed two-species competitive model with stage structure. By means of Mawhin’s continuation theorem of coincidence degree theory, some sufficient conditions are obtained for the existence of at least one positive almost periodic solutions for the above model with nonnegative coefficients. Furthermore, the global asymptotical stability of positive almost periodic solution of the model is also studied. The work of this paper extends and improves some results in recent years. An example and simulations are employed to illustrate the main results of this paper.
- Published
- 2019
- Full Text
- View/download PDF
22. Analysis of a Stochastic Competitive Model with Regime Switching.
- Author
-
Meiling Deng
- Subjects
- *
STOCHASTIC analysis , *MARKOV processes - Abstract
This paper is concerned with a stochastic competitive model with Markov switching. Sufficient conditions for stochastic permanence, extinction, global attractivity and stability in distribution are established. Some numerical figures are introduced to validate the theoretical results. [ABSTRACT FROM AUTHOR]
- Published
- 2015
23. Remanufacturer-Manufacturer Collaboration in a Supply Chain: The Manufacturer Plays the Leader Role.
- Author
-
Wang, Kai, Xiong, Zhongkai, Xiong, Yu, and Yan, Wei
- Subjects
MANUFACTURING processes ,SUPPLY chains ,COMPARATIVE studies ,ECONOMIC competition ,CLOSED loop systems - Abstract
This paper adds to the growing remanufacturing literature by investigating a collaborative model in which the manufacturer serves as the remanufacturer's distributor while selling its own product. The paper extends the collaborative model that we have studied previously by characterizing it as a channel power structure under which the manufacturer plays the leader role in the collaboration. Furthermore, the paper compares this collaborative model with a competitive model in which the manufacturer competes with the remanufacturer in the market on pricing, sales volume and profit and finds that even if the manufacturer chooses to collaborate with the remanufacturer, it does not give up its market position; the manufacturer keeps the price of its product unchanged as the remanufactured product becomes increasingly acceptable to the consumer, and its product's sales volume remains unchanged in both models. Finally, this paper observes that the collaborative model benefits the manufacturer more than the competitive model, whereas the competitive model benefits the remanufacturer more than the collaborative model. Obviously, if collaboration benefits both of the manufacturer and remanufacturer, they will choose to collaborate, and the manufacturer will transfer part of its profit to the remanufacturer, but if competition brings them more profit, they will choose to compete in the market, and the remanufacturer will transfer part of its profit to the manufacturer. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
24. Monotonicity properties arising in a simple model of Wolbachia invasion for wild mosquito populations.
- Author
-
Vicencio D, Vasilieva O, and Gajardo P
- Subjects
- Animals, Humans, Reproduction, Fertility, Population Dynamics, Wolbachia, Aedes
- Abstract
In this paper, we propose a simplified bidimensional Wolbachia infestation model in a population of Aedes aegypti mosquitoes, preserving the main features associated with the biology of this species that can be found in higher-dimensional models. Namely, our model represents the maternal transmission of the Wolbachia symbiont, expresses the reproductive phenotype of cytoplasmic incompatibility, accounts for different fecundities and mortalities of infected and wild insects, and exhibits the bistable nature leading to the so-called principle of competitive exclusion . Using tools borrowed from monotone dynamical system theory, in the proposed model, we prove the existence of an invariant threshold manifold that allows us to provide practical recommendations for performing single and periodic releases of Wolbachia -carrying mosquitoes, seeking the eventual elimination of wild insects that are capable of transmitting infections to humans. We illustrate these findings with numerical simulations using parameter values corresponding to the wMelPop strain of Wolbachia that is considered the best virus blocker but induces fitness loss in its carriers. In these tests, we considered multiple scenarios contrasting a periodic release strategy against a strategy with a single inundative release, comparing their effectiveness. Our study is presented as an expository and mathematically accessible tool to study the use of Wolbachia-based biocontrol versus more complex models.
- Published
- 2023
- Full Text
- View/download PDF
25. Discrete competitive lotka–volterra model with controllable phase volume
- Author
-
Voroshilova, A., Wafubwa, J., Voroshilova, A., and Wafubwa, J.
- Abstract
The simulation of population dynamics and social processes is of great interest in nonlinear systems. Recently, many scholars have paid attention to the possible applications of population dynamics models, such as the competitive Lotka–Volterra equation, in economic, demographic and social sciences. It was found that these models can describe some complex behavioral phenomena such as marital behavior, the stable marriage problem and other demographic processes, possessing chaotic dynamics under certain conditions. However, the introduction of external factors directly into the continuous system can influence its dynamic properties and requires a reformulation of the whole model. Nowadays most of the simulations are performed on digital computers. Thus, it is possible to use special numerical techniques and discrete effects to introduce additional features to the digital models of continuous systems. In this paper we propose a discrete model with controllable phase-space volume based on the competitive Lotka–Volterra equations. This model is obtained through the application of semi-implicit numerical methods with controllable symmetry to the continuous competitive Lotka–Volterra model. The proposed model provides almost linear control of the phase-space volume and, consequently, the quantitative characteristics of simulated behavior, by shifting the symmetry of the underlying finite-difference scheme. We explicitly show the possibility of introducing almost arbitrary law to control the phase-space volume and entropy of the system. The proposed approach is verified through bifurcation, time domain and phase-space volume analysis. Several possible applications of the developed model to the social and demographic problems’ simulation are discussed. The developed discrete model can be broadly used in modern behavioral, demographic and social studies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Published
- 2020
26. A note on a delay Lotka–Volterra competitive system with random perturbations
- Author
-
Liu, Meng and Wang, Ke
- Subjects
- *
LOTKA-Volterra equations , *RANDOM fields , *PERTURBATION theory , *TIME delay systems , *PRESUPPOSITION (Logic) , *STABILITY theory - Abstract
Abstract: This note is concerned with a stochastic competitive system with time delays. Under a simple assumption, almost sufficient and necessary conditions for stability in time average and extinction of each population are established. Some numerical simulations are introduced to illustrate the main results. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
27. The Collaborative Enterprise.
- Author
-
Tencati, Antonio and Zsolnai, Laszlo
- Subjects
COOPERATIVE societies ,COLLECTIVISM (Social psychology) ,ECONOMIC competition ,MUTUALISM ,CORPORATE governance ,SOCIAL responsibility of business - Abstract
Instead of the currently prevailing competitive model, a more collaborative strategy is needed to address the concerns related to the sustainability of today’s business. This article aims to explore collaborative approaches where enterprises seek to build long-term, mutually beneficial relationships with all stakeholders and want to produce sustainable values for their whole business ecosystem. Cases here analyzed demonstrate that alternative ways of doing business are possible. These enterprises share more democratic ownership structures, more balanced and broader governance systems, and a more comprehensive view of organizational goals and performance – which goes beyond the narrow concept of financial bottom line and into a stronger and systematic care of the needs and requirements of the different stakeholder groups. Thanks to this evidence and different theoretical and empirical contributions, we suggest that the strength and sustainability of enterprises come from their ability to fit into the environmental, social, and cultural context in which they operate. By creating values for all stakeholders, enterprises can involve them and gain deep support based on their commitment. This may lead to superior performance from a multiple-bottom-line perspective. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
28. Competitive dynamics of e-commerce web sites
- Author
-
Yanhui, Li and Siming, Zhu
- Subjects
- *
INTERNET industry , *INTERNET , *DIFFERENTIAL equations , *INTERNET fraud - Abstract
Abstract: The characteristic of “rich gets richer” is much more conspicuous on the Internet, which is the important cause of “power-law” characteristic of the “winner-takes-all” markets. A competitive model of e-commerce web sites is presented in order to explore the effects of competition and the characteristic of “rich gets richer” on Internet economy, and also to investigate how the “winner-takes-all” phenomenon comes forth. Then these ordinary differential equations are qualitatively analyzed and numerically simulated to study the dynamics of competition. The effects of parameters on the dynamic behavior in the model are also discussed. [Copyright &y& Elsevier]
- Published
- 2007
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29. Dynamical behavior for a stochastic two-species competitive model
- Author
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Changjin Xu and Maoxin Liao
- Subjects
General Mathematics ,010103 numerical & computational mathematics ,stochastic perturbation ,92d25 ,01 natural sciences ,global stability ,010101 applied mathematics ,competitive model ,QA1-939 ,60h10 ,Statistical physics ,0101 mathematics ,60h30 ,Mathematics - Abstract
This paper deals with a stochastic two-species competitive model. Some very verifiable criteria on the global stability of the positive equilibrium of the deterministic system are established. An example with its computer simulations is given to illustrate our main theoretical findings.
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- 2017
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30. Dynamics of a diffusive competitive model on a periodically evolving domain
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Jiazhen Zhu, Jiazheng Zhou, and Zhigui Lin
- Subjects
evolving domain ,Mathematics - Analysis of PDEs ,lcsh:Mathematics ,35K57, 35K55, 92D25 ,competitive model ,diffusion ,ecological reproduction indexes ,FOS: Mathematics ,lcsh:QA1-939 ,Analysis of PDEs (math.AP) - Abstract
In this paper, we are concerned with a two-species competitive model with diffusive terms on a periodically evolving domain and study the impact of the spatial periodic evolution on the dynamics of the model. The Lagrangian transformation approach is adopted to convert the model from a changing domain to a fixed one with the assumption that the evolution of habitat is uniform and isotropic. The ecological reproduction indexes of the linearized model are given as thresholds to reveal the dynamic behaviour of the competitive model by discussing the relations between the initial boundary value problem and its corresponding periodic problem. Our theoretical results show that a lager evolving rate benefits the persistence of competitive populations for both sides in the long run. Numerical experiments illustrate that two competitive species, one of which survive and the other vanish on a fixed domain, both survive on a domain with a large evolving rate and both vanish on a domain with a small evolving rate., 15 pages, 20 figures
- Published
- 2019
31. Art, Ethics, and Economics.
- Author
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Rider, Christine
- Subjects
- *
ECONOMICS , *ART , *ETHICS , *PRODUCT safety , *NATURAL resources ,COMPETITION - Abstract
A comparison of the neoclassical and the social economics paradigms, showing that the explicit inclusion of values enhances the explanatory value of social economics. This is illustrated by using literary examples to explain the difficulty the competitive model has in providing analyses and solutions for modem problems of product safety, natural resource overexploitation, urban congestion, and stakeholder rights. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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- View/download PDF
32. Investigation of the electrical energy market of ukraine: economic aspect
- Subjects
монополістична модель ,енергоефективність ,competitive model ,monopolistic model ,energy intensity of products ,electric power market ,балансуючий ринок ,competitive advantages ,енергомісткість продукції ,конкурентні переваги ,balancing market ,конкурентна модель ,energy efficiency - Abstract
Аналіз економічної складової нового ринку електричної енергії дозволяє визначити можливість забезпечення конкурентних переваг підприємства за рахунок зменшення енергомісткості продукції, що є актуальною проблемою дослідження. Мета статті – дослідити можливості нового ринку електричної енергії для підприємств та визначити напрями нарощування їх конкурентних переваг. Новий ринок електричної енергії розглядається як можливість інтегрування енергетичного ринку України в загальноєвропейський простір. Перешкодами на шляху нового ринку електричної енергії є незадовільний стан мереж, небезпека кібератак, залежність від постачальників ресурсів, значний рівень заборгованості на оптовому ринку електричної енергії. В умовах нового ринку електроенергії підприємству доцільно розробляти стратегію в галузі організації електропостачання як частину його стратегічного набору. Лімітування концентрації ризиків та диверсифікація портфелю угод з енергопостачаючими компаніями розглядаються як найбільш ефективні заходи з мінімізації ризиків в системі управління ризиками підприємства на новому ринку електричної енергії. Виділені кон’юнктуроутворюючі фактори на ринку електричної енергії: конкурентна ситуація на ринку, платоспроможність споживачів електричної енергії, інвестиційна привабливість енергетичної галузі, інтенсивність використання альтернативних джерел енергії. Забезпечення конкурентних переваг підприємства в умовах нового ринку електричної енергії досліджується з позиції ресурсного та поведінкового підходів. Оптимізація структури собівартості продукції підприємства за рахунок зменшення енергетичної складової розглядається як частина організаційних заходів з удосконалення управління ресурсним потенціалом підприємства. Зроблено висновок про сприятливий вплив нової конкурентної моделі ринку електричних послуг на суб’єкти цього ринку. Analysis of the economic component of the new electric power market allows determining the possibility of ensuring the competitive advantages of an enterprise by reducing the energy intensity of products, which is a pressing issue of the study. The purpose of the article is to explore the possibilities of a new electric power market for enterprises and to determine the directions for increasing their competitive advantages. A new electricity market is seen as an opportunity to integrate the energy market of Ukraine into the pan-European space. Obstacles to the new electricity market are the unsatisfactory condition of networks, the danger of cyber-attacks, dependence on resource providers, and a significant level of debt on the wholesale electricity market. Under the conditions of a new electricity market, an enterprise should develop a strategy in the field of power supply organization as part of its strategic set. Limiting risk concentrations and diversifying the portfolio of contracts with energy supplying companies are considered as the most effective measures to minimize risks in the enterprise’s risk management system in the new electricity market. Dedicated conjuncture factors in the electricity market are the competitive situation in the market, the solvency of consumers of electricity, the investment attractiveness of the energy field, the intensity of use of alternative energy sources. Ensuring the competitive advantages of the enterprise in the new electricity market is investigated from the perspective of the resource and behavioral approaches. Optimization of the cost structure of the enterprise’s products, by reducing the energy component, is considered as part of the organizational measures to improve the management of its resource potential. The conclusion is made about the favorable influence of the new competitive model of the market of electric services on the subjects of this market.
- Published
- 2019
33. Application of the Nullcline Method to a Certain Model of Competitive Species
- Author
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Vahidin Hadžiabdić, Midhat Mehuljić, Jasmin Bektešević, and Isad Šarić
- Subjects
Competitive model ,Growth rate ,lcsh:T ,lcsh:L ,Equilibrium Point ,lcsh:Technology ,Stability ,lcsh:Education ,Nullcline - Abstract
TEM Journal; Vol 8, No 1, 2019. ISSN 2217-8309, In this paper we will observe the model of competitive types and it will be analyzed using the nullcline method. It will be shown that this model has four points of equilibria, which are stable or unstable depending on the parameters a and b. The local stability of these points was investigated and global dynamics was determined using nullcline methods, that is, the bases of attraction of these points were shown.
- Published
- 2019
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- View/download PDF
34. Factores estratégicos que influyen en el desarrollo del proceso asociativo empresarial de los productores de pisco del valle de Lunahuana, provincia de Cañete
- Author
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Chavez Gallo, Rodolfo Marcial and Cuadra Rodríguez, Orlando
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Asociatividad empresarial ,Management model producers network ,Capital social ,Organizational culture ,Business association ,Modelo de gestión ,Public policies ,Cadena de valor ,Modelo competitivo ,Competitive model ,Social capital ,Value chain ,Strategic alliances ,Cultura organizacional ,Políticas públicas ,Red de productores ,Alianzas estratégicas - Abstract
En las etapas previas, al inicio del proceso formal de la presente investigación, se observó que los productores de pisco del distrito de Lunahuaná, distrito de Cañete, no obstante la calidad de su producto, afrontaban problemas para la estandarización de la producción y la comercialización rentable del mismo, aspecto que resulta muy importante en una comunidad cuyo 60% es altamente dependiente de la agricultura. El tipo de investigación fue aplicada y el diseño descriptivo-correlativo, no experimental y transversal. La población estuvo conformada por 33 productores (11 formales y 22 no formales). In the previous stages, at the beginning of the formal process of the present investigation, it was observed that the producers of pisco of the district of Lunahuaná, province of Cañete, despite the quality of their product, faced problems for the standardization of production and commercialization, which is very important in a community whose 60% is highly dependent on agriculture. The type of research was applied and the descriptive-correlative, non- experimental and transversal design. The population consisted of 33 producers (11 formalized producers and 22 non formalized producers). Tesis
- Published
- 2018
35. Discrete Competitive Lotka–Volterra Model with Controllable Phase Volume.
- Author
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Voroshilova, Anzhelika and Wafubwa, Jeff
- Subjects
LOTKA-Volterra equations ,SOCIAL sciences education ,VOLTERRA equations ,PHASE space ,POPULATION dynamics ,NONLINEAR systems ,SOCIAL dynamics - Abstract
The simulation of population dynamics and social processes is of great interest in nonlinear systems. Recently, many scholars have paid attention to the possible applications of population dynamics models, such as the competitive Lotka–Volterra equation, in economic, demographic and social sciences. It was found that these models can describe some complex behavioral phenomena such as marital behavior, the stable marriage problem and other demographic processes, possessing chaotic dynamics under certain conditions. However, the introduction of external factors directly into the continuous system can influence its dynamic properties and requires a reformulation of the whole model. Nowadays most of the simulations are performed on digital computers. Thus, it is possible to use special numerical techniques and discrete effects to introduce additional features to the digital models of continuous systems. In this paper we propose a discrete model with controllable phase-space volume based on the competitive Lotka–Volterra equations. This model is obtained through the application of semi-implicit numerical methods with controllable symmetry to the continuous competitive Lotka–Volterra model. The proposed model provides almost linear control of the phase-space volume and, consequently, the quantitative characteristics of simulated behavior, by shifting the symmetry of the underlying finite-difference scheme. We explicitly show the possibility of introducing almost arbitrary law to control the phase-space volume and entropy of the system. The proposed approach is verified through bifurcation, time domain and phase-space volume analysis. Several possible applications of the developed model to the social and demographic problems' simulation are discussed. The developed discrete model can be broadly used in modern behavioral, demographic and social studies. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
36. Competetive potential in the regional management
- Author
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O. V. Komelina and V. V. Rzhepishevskaya
- Subjects
assessment ,lcsh:Regional economics. Space in economics ,Competitive advantage ,Regional policy ,Competition (economics) ,competitive potential ,structure ,competitive advantages ,Set (psychology) ,Industrial organization ,Shift-share analysis ,General Environmental Science ,Sustainable development ,region ,competitiveness ,business.industry ,Corporate governance ,Environmental resource management ,General Social Sciences ,General Business, Management and Accounting ,lcsh:HT388 ,monitoring ,competitive model ,regional management ,Productive forces ,Business ,General Economics, Econometrics and Finance - Abstract
Modern regional management needs special regional policy aimed at making the competitive potential of the region as a factor of its sustainable development. In this regard, the main task of this study is to base the nature, structure and destination of competitive potential for regional management, as well as the development of its grade methodology. It is proposed to consider the competitive potential of the region as a set of available resources, tools, and sources of various properties, which belong to the territory and which help to attract attention of aimed customers (investors, entrepreneurs, residents, tourists, etc.) at it, increase of the demand for some of its elements, which can be used in competition, making unique resources and capabilities into competitive advantages. Along with the traditional elements of the competitive potential of the region some elements were offered to include in its structure. Those elements show modern organizational and economic relations of the regional productive forces. The assessing technique of the competitive potential level of the region was developed. One of its most important areas of practical use the results are the organization of the formation potential monitoring for local, regional, and national governance.
- Published
- 2014
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- View/download PDF
37. Lexical selection and verbal self-monitoring: Effects of lexicality, context, and time pressure in picture-word interference
- Author
-
Robert J. Hartsuiker and Elisah Dhooge
- Subjects
Linguistics and Language ,Speech production ,Picture-word interference task ,Social Sciences ,Experimental and Cognitive Psychology ,Context (language use) ,LANGUAGE PRODUCTION ,Pseudowords ,Language and Linguistics ,SPEECH PRODUCTION ,Task (project management) ,Competitive model ,DISTRACTOR FREQUENCY ,Artificial Intelligence ,SPREADING-ACTIVATION THEORY ,ELICITED SLIPS ,INNER SPEECH ,Spreading activation ,RESPONSE EXCLUSION ,Lexical selection ,Language production ,Context effect ,SEMANTIC INTERFERENCE ,Pseudoword ,Neuropsychology and Physiological Psychology ,Verbal self-monitoring ,TASK ,Task analysis ,Psychology ,LEMMA RETRIEVAL ,Cognitive psychology - Abstract
Current views of lexical selection in language production differ in whether they assume lexical selection by competition or not. To account for recent data with the picture-word interference (PWI) task, both views need to be supplemented with assumptions about the control processes that block distractor naming. In this paper, we propose that such control is achieved by the verbal self-monitor. If monitoring is involved in the PWI task, performance in this task should be affected by variables that influence monitoring such as lexicality, lexicality of context, and time pressure. Indeed, pictures were named more quickly when the distractor was a pseudoword than a word (Experiment 1), which reversed in a context of pseudoword items (Experiment 3). Additionally, under time pressure, participants frequently named the distractor instead of the picture, suggesting that the monitor failed to exclude the distractor response. Such errors occurred more often with word than pseudoword distractors (Experiment 2); however, the effect flipped around in a pseudoword context (Experiment 4). Our findings argue for the role of the monitoring system in lexical selection. Implications for competitive and non-competitive models are discussed.
- Published
- 2012
- Full Text
- View/download PDF
38. Stability and Hopf bifurcation for a delayed diffusive competition model with saturation effect.
- Author
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Xu C, Li Q, Zhang T, and Yuan S
- Abstract
This paper presents an investigation on the dynamics of a delayed diffusive competition model with saturation effect. We first perform the stability analysis of the positive equilibrium and the existence of Hopf bifurcations. It is shown that the positive equilibrium is asymptotically stable under some conditions, and that there exists a critical value of delay, when the delay increases across it, the positive equilibrium loses its stability and a spatially homogeneous or inhomogeneous periodic solution emerges from the positive equilibrium. Then, we derive the formulas for the determination of the direction of Hopf bifurcation and the properties of the bifurcating periodic solutions. Finally, some numerical simulations are performed to illustrate the obtained results.
- Published
- 2020
- Full Text
- View/download PDF
39. The Collaborative Enterprise
- Author
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Antonio Tencati and Laszlo Zsolnai
- Subjects
Economics and Econometrics ,Knowledge management ,media_common.quotation_subject ,Stakeholder engagement ,Collaborative Enterprise ,Competitive Model ,Corporate Governance ,Shareholder Value ,Stakeholder Engagement ,Sustainable Values ,Arts and Humanities (miscellaneous) ,Economics ,Business and International Management ,media_common ,business.industry ,Corporate governance ,Stakeholder ,Public relations ,Business ecosystem ,General Business, Management and Accounting ,Shareholder value ,Democracy ,Sustainability ,Business ethics ,business ,Law - Abstract
Instead of the currently prevailing competitive model, a more collaborative strategy is needed to address the concerns related to the unsustainability of today’s business. This article aims to explore collaborative approaches where enterprises seek to build long-term, mutually beneficial relationships with all stakeholders and want to produce sustainable values for their whole business ecosystem. Cases here analyzed demonstrate that alternative ways of doing business are possible. These enterprises share more democratic ownership structures, more balanced and broader governance systems, and a more comprehensive view of organizational goals and performance – which goes beyond the narrow concept of financial bottom line and into a stronger and systematic care of the needs and requirements of the different stakeholder groups. Thanks to this evidence and different theoretical and empirical contributions, we suggest that the strength and sustainability of enterprises come from their ability to fit into the environmental, social, and cultural context in which they operate. By creating values for all stakeholders, enterprises can involve them and gain deep support based on their commitment. This may lead to superior performance from a multiple-bottom-line perspective.
- Published
- 2008
- Full Text
- View/download PDF
40. Cationic porphyrins are tunable gatekeepers of the 20S proteasome
- Author
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Anna Maria Santoro, Danilo Milardi, Grazia R. Tundo, Antonio Di Dato, Caterina Fattorusso, Marco Persico, Diego Sbardella, Massimiliano Coletta, Chiara Ciaccio, Alessandra Cunsolo, Roberto Fattorusso, Alessandro D'Urso, Donatella Diana, Roberto Purrello, Santoro, Anna M., Cunsolo, Alessandra, D'Urso, Alessandro, Sbardella, Diego, Tundo, Grazia R., Ciaccio, Chiara, Coletta, Massimiliano, Diana, Donatella, Fattorusso, Roberto, Persico, Marco, Di Dato, Antonio, Fattorusso, Caterina, Milardi, Danilo, Purrello, Roberto, and DI DATO, Antonio
- Subjects
0301 basic medicine ,chemistry.chemical_classification ,Chemistry ,Stereochemistry ,Chemistry (all) ,Cationic polymerization ,General Chemistry ,Gating ,allosteric inhibition ,cancer treatment ,03 medical and health sciences ,030104 developmental biology ,Enzyme ,Proteasome ,Docking (molecular) ,Proteome ,competitive model ,Molecule ,Enzyme kinetics ,Settore BIO/10 - Abstract
The 20S proteasome is a barrel-shaped enzymatic assembly playing a critical role in proteome maintenance. Access of proteasome substrates to the catalytic chamber is finely regulated through gating mechanisms which involve aromatic and negatively charged residues located at the N-terminal tails of α subunits. However, despite the importance of gates in regulating proteasome function, up to now very few molecules have been shown to interfere with the equilibrium by which the catalytic channel exchanges between the open and closed states. In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine experimental (enzyme kinetics, UV stopped flow and NMR) and computational (bioinformatic analysis and docking studies) approaches to inspect proteasome inhibition by meso-tetrakis(4-N-methylpyridyl)-porphyrin (H2T4) and its two ortho- and meta-isomers. We show that in a first, fast binding event H2T4 accommodates in a pocket made of negatively charged and aromatic residues present in α1 (Asp10, Phe9), α3 (Tyr5), α5 (Asp9, Tyr8), α6 (Asp7, Tyr6) and α7 (Asp9, Tyr8) subunits thereby stabilizing the closed conformation. A second, slower binding mode involves interaction with the grooves which separate the α- from the β-rings. Of note, the proteasome inhibition by ortho- and meta-H2T4 decreases significantly if compared to the parent compound, thus underscoring the role played by spatial distribution of the four peripheral positive charges in regulating proteasome-ligand interactions. We think that our results may pave the way to further studies aimed at rationalizing the molecular basis of novel, and more sophisticated, proteasome regulatory mechanisms. The 20S proteasome is a barrel-shaped enzymatic assembly playing a critical role in proteome maintenance. Access of proteasome substrates to the catalytic chamber is finely regulated through gating mechanisms which involve aromatic and negatively charged residues located at the N-terminal tails of α subunits. However, despite the importance of gates in regulating proteasome function, up to now very few molecules have been shown to interfere with the equilibrium by which the catalytic channel exchanges between the open and closed states. In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine experimental (enzyme kinetics, UV stopped flow and NMR) and computational (bioinformatic analysis and docking studies) approaches to inspect proteasome inhibition by meso-tetrakis(4-N-methylpyridyl)-porphyrin (H2T4) and its two ortho- and meta-isomers. We show that in a first, fast binding event H2T4 accommodates in a pocket made of negatively charged and aromatic residues present in α1 (Asp10, Phe9), α3 (Tyr5), α5 (Asp9, Tyr8), α6 (Asp7, Tyr6) and α7 (Asp9, Tyr8) subunits thereby stabilizing the closed conformation. A second, slower binding mode involves interaction with the grooves which separate the α- from the β-rings. Of note, the proteasome inhibition by ortho- and meta-H2T4 decreases significantly if compared to the parent compound, thus underscoring the role played by spatial distribution of the four peripheral positive charges in regulating proteasome-ligand interactions. We think that our results may pave the way to further studies aimed at rationalizing the molecular basis of novel, and more sophisticated, proteasome regulatory mechanisms.
- Published
- 2016
- Full Text
- View/download PDF
41. Risk Sharing in Labour Markets
- Author
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Abena D. Oduro, Stefan Dercon, Måns Söderbom, Paul Collier, Bernard Gauthier, Albert Zeufack, Arne Bigsten, Jan Willem Gunning, Remco Oostendorp, Francis Teal, Marcel Fafchamps, Cathy Pattillo, and Economics
- Subjects
ECONOMIC PERFORMANCE ,EQUILIBRIUM UNEMPLOYMENT ,DEVELOPING COUNTRY ,VALUE ADDED ,WORKER HETEROGENEITY ,COMMERCIAL CONTRACTS ,TRANSACTION COSTS ,Efficiency wage ,FIRM SIZE ,Economics ,EMPLOYMENT ,STOCKS ,WAGE DIFFERENTIALS ,GOVERNMENT INTERVENTION ,IMPLICIT CONTRACTS ,RISK AVERSION ,MISSING MARKETS ,health care economics and organizations ,AVERAGE WAGES ,media_common ,UNEMPLOYMENT ,INCOME ,INSTRUMENT ,PRODUCTIVITY ,Risk aversion ,WORKERS ,COBB-DOUGLAS PRODUCTION FUNCTION ,Market liquidity ,EXOGENOUS SHOCKS ,OCCUPATION ,Profitability index ,COMPETITIVE MODEL ,NEGATIVE SHOCKS ,LABOR SUPPLY ,FINANCIAL MARKETS ,PRIMARY EDUCATION ,media_common.quotation_subject ,INVENTORIES ,HOLDING ,NEGATIVE SHOCK ,DEVELOPMENT ECONOMICS ,WORKER ,Development ,UNEMPLOYED ,WAGES ,OPTIMAL CONTRACT ,LABOR MARKET ,WAGE EFFECT ,ELASTICITY ,TOTAL OUTPUT ,LIQUIDITY ,CREDIT RATIONING ,EXPECTED VALUE ,CONTRACT ENFORCEMENT ,ECONOMIC DEVELOPMENT ,FIRM PERFORMANCE ,Panel data ,CRISES ,WAGE PREMIUM ,Labour economics ,BARGAINING POWER ,ECONOMIC RENTS ,RENTS ,WAGE RIGIDITY ,WAGE BILL ,TOTAL WAGE ,EMPLOYEE ,PERMANENT SHOCK ,WAGE LEVELS ,WAGE RATES ,POLITICAL ECONOMY ,RISK SHARING ,AVERAGE WAGE ,EXPORTS ,WAGE BARGAINING ,Empirical work ,PRODUCTION WORKERS ,LIQUIDITY CRISES ,Economic rent ,INSURANCE MARKET ,RISK PREMIUM ,CAPITAL STOCK ,SUPPLIERS ,Implicit contract theory ,EXCHANGE RATE ,LABOR ECONOMICS ,DISPUTE ¨ RESOLUTION ,HUMAN CAPITAL ,INSURANCE ,ECONOMETRIC ANALYSIS ,Bond market ,LABOR CONTRACTS ,LABOR TURNOVER ,BARGAINING ,Economics and Econometrics ,EFFICIENCY WAGES ,Risk premium ,BORROWING ,DUMMY VARIABLES ,INEFFICIENCY ,PRICE VOLATILITY ,WAGE RATE ,INFORMAL CREDIT ,INTERNATIONAL BANK ,Accounting ,RATES OF RETURN ,Risk sharing ,MONETARY FUND ,LABOR MARKETS ,SUPPLY CURVE ,CONTRACTUAL RELATIONS ,RISK AVERSE ,SDG 8 - Decent Work and Economic Growth ,CREDIT MARKETS ,WORK EXPERIENCE ,WAGE INCREASE ,LABOR FORCE ,PRODUCTION FUNCTION ,INSURANCE MARKETS ,LIQUID ASSETS ,PERMANENT SHOCKS ,HIGH WAGE ,IMPLICIT CONTRACT ,CREDIT MARKET ,Finance ,TRANSACTION - Abstract
Empirical work in labor economics has focused on rent sharing as an explanation for the observed correlation between wages and profitability. The alternative explanation of risk sharing between workers and employers has not been tested. Using a unique panel data set for four African countries, Authors find strong evidence of risk sharing. Workers in effect offer insurance to employers: when firms are hit by temporary shocks, the effect on profits is cushioned by risk sharing with workers. Rent sharing is a symptom of an inefficient labor market. Risk sharing; by contrast, can be seen as an efficient response to missing markets. Authors evidence suggests that risk sharing accounts for a substantial part of the observed effect of shocks on wages.
- Published
- 2003
- Full Text
- View/download PDF
42. Dynamic Analysis of a Two-Language Competitive Model with Control Strategies
- Author
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Il Hyo Jung, Lin-Fei Nie, Zhi-Dong Teng, Juan J. Nieto, and Universidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización
- Subjects
Mathematical optimization ,Article Subject ,General Mathematics ,lcsh:Mathematics ,General Engineering ,Stability (learning theory) ,Dynamic Analysis ,Dynamical system ,Optimal control ,lcsh:QA1-939 ,Qualitative analysis ,Competitive model ,Linearization ,lcsh:TA1-2040 ,Control Strategies ,Control (linguistics) ,lcsh:Engineering (General). Civil engineering (General) ,Differential inequalities ,Poincaré map ,Mathematics - Abstract
The dynamic behavior of a two-language competitive model is analyzed systemically in this paper. By the linearization and the Bendixson-Dulac theorem on dynamical system, some sufficient conditions on the globally asymptotical stability of the trivial equilibria and the existence and the stability of the positive equilibrium of this model are presented. Nextly, in order to protect the endangered language, an optimal control problem relative to this model is explored. We derive some necessary conditions to solve the optimal control problem and present some numerical simulations using a Runge-Kutta fourth-order method. Finally, the languages competitive model is extended to this model assessing the impact of state-dependent pulse control strategy. Using the Poincaré map, differential inequality, and method of qualitative analysis, we prove the existence and stability of positive order-1 periodic solution for this control model. Numerical simulations are carried out to illustrate the main results and the feasibility of state-dependent impulsive control strategy. This paper has been partially supported by the Scientific Research Programmes of Colleges in Xinjiang (Grant no. XJEDU2011S08), the Natural Science Foundation of Xinjiang (Grant no. 2011211B08), the National Natural Science Foundation of China (Grants nos. 11001235, 11271312, and 11261056), the China Postdoctoral Science Foundation (Grants nos. 20110491750 and 2012T50836), and the Ministerio de Economia y Competitividad (Spain), Project no. MTM2010-15314 and has been co-financed by the European Community Fund FEDER SI
- Published
- 2013
- Full Text
- View/download PDF
43. Distant Services as part of the competitive model of banking business
- Subjects
bank ,competitive model ,конкурентна модель ,банк - Abstract
Аналізується значення впровадження моделі дистанційного обслуговування та технологізації процесів комунікації з клієнтом на позиціонування банківської установи на ринку та підвищення її рейтингові показники. The significance of the implementation of the distance service model and the technological process of communication with the client on the positioning of the banking institution in the market and increase of its rating indicators is analyzed.
- Published
- 2010
44. Tirdzniecības uzņēmumu konkurētspējas modelis
- Author
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Žunna, K and Magidenko, A
- Subjects
Portugal ,quality ,Trading companies ,competitive model ,competition ,Latvia - Abstract
Lai tirdzniecības uzņēmumi izdzīvotu, tiem nepieciešams izcelties uz pārējo uzņēmumu fona. Tātad jebkuram tirdzniecības uzņēmumam nepieciešams saimnieciskās darbības konkurētspējīgs modelis, jo ekonomiskā ziņā konkurence kalpo kā progresa noteicošā svira. Turklāt ir labāk, ja šis modelis tendēts uz darbošanos ilgtermiņā. Latvijas uzņēmējiem trūkst vīzijas tirdzniecības uzņēmuma saimnieciskās darbības organizēšanā. Viņu uzskati ir pārāk konservatīvi, kas atbilst Latvijas iedzīvotāju temperamentam (cilvēki no valstīm, kas atrodas tālāk no ekvatora, ir vairāk intraverti un aizspriedumaini, turpretī cilvēki, kuri dzīvo tuvāk ekvatoram, ir komunikablāki, draudzīgāki un atvērtāki jaunām idejām), tāpēc tiek meklēts oriģināls veids, kā celt tirdzniecības uzņēmuma reitingu klienta acīs. Rakstā aplūkota tirdzniecības uzņēmumu loma tautsaimniecības attīstībā, pēc tam veikts Latvijas un Portugāles salīdzinājums pēc dažādām segmentācijas pazīmēm. Rakstu noslēdz nozares problēmu un plusu konstatējums. Rakstā apskatīta konkurence kā ekonomiskās uzvedības veids, un pēc konkurētspējas rādītāju analīzes izriet autoru trīs novitātes. Rakstā nolemts, kādas metodes tiks izmantotas. Rakstā autore attēlo tirdzniecības uzņēmumu konkurētspējas modeli, balstoties uz aptaujā iegūtajiem rezultātiem, parāda, kā tas varētu darboties praksē, sīki izskaidrojot katru apakšrādītāju. Raksta noslēgumā ar faktoru salīdzināšanas metodi novērtēts konkurētspējas līmenis par piemēru paņemtajam tirdzniecības uzņēmumam un parādīta darba efektivitāte.
- Published
- 2010
45. Dynamic Analysis of a Two-Language Competitive Model with Control Strategies
- Author
-
Universidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización, Nie, Lin-Fei, Teng, Zhi-Dong, Nieto Roig, Juan José, Jung, Il Hyo, Universidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización, Nie, Lin-Fei, Teng, Zhi-Dong, Nieto Roig, Juan José, and Jung, Il Hyo
- Abstract
The dynamic behavior of a two-language competitive model is analyzed systemically in this paper. By the linearization and the Bendixson-Dulac theorem on dynamical system, some sufficient conditions on the globally asymptotical stability of the trivial equilibria and the existence and the stability of the positive equilibrium of this model are presented. Nextly, in order to protect the endangered language, an optimal control problem relative to this model is explored. We derive some necessary conditions to solve the optimal control problem and present some numerical simulations using a Runge-Kutta fourth-order method. Finally, the languages competitive model is extended to this model assessing the impact of state-dependent pulse control strategy. Using the Poincaré map, differential inequality, and method of qualitative analysis, we prove the existence and stability of positive order-1 periodic solution for this control model. Numerical simulations are carried out to illustrate the main results and the feasibility of state-dependent impulsive control strategy.
- Published
- 2013
46. Exports, Foreign Direct Investment and the Costs of Corporate Taxation
- Author
-
Keuschnigg, Christian
- Subjects
Multinationales Unternehmen ,H25 ,FDI ,L22 ,foreign direct investment ,Körperschaftsteuer ,Monopolistischer Wettbewerb ,ComputingMilieux_LEGALASPECTSOFCOMPUTING ,effective marginal tax rate ,Internationale Markteintrittsstrategie ,ddc:330 ,effective tax rates ,corporate taxation ,exports ,business investment ,Excess Burden ,industry ,monopol ,L11 ,costs of public funds ,Direktinvestition ,elasticities of investment ,Competitiveness ,effective average tax rate ,competitive model ,tax rates ,capital stock ,extensive and intensive investment ,Export ,F23 ,D21 ,Theorie - Abstract
This paper develops a model of a monopolistically competitive industry with extensive and intensive business investment and shows how these margins respond to changes in average and marginal corporate tax rates. Intensive investment refers to the size of a firm's capital stock. Extensive investment refers to the firm's production location and reflects the trade-off between exports and foreign direct investment as alternative modes of foreign market access. The paper derives comparative static effects of the corporate tax and shows how the cost of public funds depends on the measures of effective marginal and average tax rates and on the behavioral elasticities of extensive and intensive investment.
- Published
- 2007
47. O Valor do Design para a Indústria Portuguesa e a Inovação e as Políticas Industriais dos anos 90
- Author
-
Maria Manuela Barros Maia and Ferreira, José Maria Carvalho
- Subjects
políticas industriais ,industrial politics ,PME's ,competitiveness ,inovação ,design ,competitive model ,competitividade ,SME's ,modelo competitivo ,innovation - Abstract
Mestrado em Sociologia Económica e das Organizações Abordam-se nesta dissertação quatro áreas de conhecimento: design, competitividade, inovação e políticas industriais. As políticas industrias portuguesas assumiram, para o período analisado, a existência de uma relação entre design e competitividade. Tendo como objecto as empresas industrias portuguesas (PME's), pretende-se discutir esta assunção através da reflexão sobre o valor do design para a inovação, tratando: desenvolvimento de produtos, tecnologia, I&D, organização e performance financeira. A compreensão dos traços mais determinantes da industrialização portuguesa e do desenvolvimento do design em Portugal, faz assentar esta discussão numa base que permite identificar e compreender o entendimento que foi feito do design nas políticas industriais. O design deterá um papel efectivo na construção da competitividade da industria portuguesa se for realizada a sua instrumentalização completa. Esta reflexão avança com perspectivas para um modelo competitivo para Portugal integrando design. Four areas of knowledge are approached In this essay: design, competitiveness, innovation and industrial politics. The Portuguese industrial politics have assumed, for the analysed period, the existence of a relation between design and competitiveness. Having in mind the industrial enterprises (SME's) as the main goal, it is important to discuss the assumption through the consideration of the value of the design regarding innovation, taking into account: product development, technology, R&D, organization and financial performance. The understanding of the most important facts of the Portuguese industrialization and development of the design in Portugal allow us to identify and perceive the role of design in the industrial policies. If the design's role is fully implemented. It will have an effective impact in the construction of competitiveness in the Portuguese industry. This consideration aims at the achieving a competitive model in/for Portugal wich would also include design.
- Published
- 2005
48. Tracking the invisible hand: Convergence of double auctions to competitive equilibrium
- Author
-
Bosch-Domènech, Antoni, Sunder, Shyam, and Universitat Pompeu Fabra. Departament d'Economia i Empresa
- Subjects
TheoryofComputation_MISCELLANEOUS ,leex ,double auction ,competitive model ,Microeconomics ,equilibrium ,experimental economics - Abstract
Economics is the science of want and scarcity. We show that want and scarcity, operating within a simple exchange institution (double auction), are sufficient for an economy consisting of multiple inter--related markets to attain competitive equilibrium (CE). We generalize Gode and Sunder's (1993a, 1993b) single--market finding to multi--market economies, and explore the role of the scarcity constraint in convergence of economies to CE. When the scarcity constraint is relaxed by allowing arbitrageurs in multiple markets to enter speculative trades, prices still converge to CE, but allocative efficiency of the economy drops. \\ Optimization by individual agents, often used to derive competitive equilibria, are unnecessary for an actual economy to approximately attain such equilibria. From the failure of humans to optimize in complex tasks, one need not conclude that the equilibria derived from the competitive model are descriptively irrelevant. We show that even in complex economic systems, such equilibria can be attained under a range of surprisingly weak assumptions about agent behavior.
- Published
- 1996
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