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1. Prevalência de fibrilação atrial sem diagnóstico ou tratamento na Atenção Primária à Saúde em Joinville, Brasil

Author

Marcelo Pitombeira de Lacerda, Cristianne Confessor Castilho Lopes, Henrique Diegoli, João Pedro Ribeiro Baptista, Clovis Hoepfner, Aline Gabrielle de Souza Berkenbrock, Juliana Safanelli, Tamires Almeida Moraes, Kendra Lys Calixto Machado, Iohana Vitória Dalri, Gabriela da Costa Werlang, and Paulo Henrique Condeixa de França

Subjects
fibrilação atrial, Atenção Primária à Saúde, controle de população, saúde do idoso, Acidente vascular cerebral, Medicine
Abstract

Introdução: A estimativa da prevalência de fibrilação atrial (FA) sem diagnóstico ou tratamento é crucial para a prevenção do acidente vascular cerebral isquêmico (AVCI) relacionado à FA. Objetivo: Avaliar a prevalência de FA sem diagnóstico ou tratamento na Atenção Primária à Saúde. Métodos: Realizamos um estudo prospectivo transversal não randomizado em Joinville, Brasil, entre indivíduos idosos em Unidades Básicas de Saúde (UBS). Resultados: Foram incluídos mil indivíduos, com idade média de 69 ± 7 anos, 57% dos quais eram mulheres. A prevalência de FA foi de 3%, com 50% dos pacientes com FA não-diagnosticada e 33% dos pacientes diagnosticados previamente sem receber anticoagulação oral apesar de indicação clínica. Usando prevalências padronizadas por idade, estimamos 68 e 27.342 AVCI por ano devido à FA sem diagnóstico ou tratamento em Joinville e no Brasil, respectivamente. Conclusão: A observação de que dois em cada três pacientes com FA estavam sem diagnóstico ou tratamento é muito alarmante. Estratégias de rastreamento para alcançar esta população são urgentemente necessárias.

Published
2024
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2. Assessment of Quality of Life and Respiratory Functional Capacity in Individuals Recovered from COVID-19

Author

Cristianne Confessor Castilho Lopes, Daniela dos Santos, Gizele Locatelli, Tulio Gamio Dias, Ana Paula de Oliveira Barbosa, Eduardo Barbosa Lopes, Lucas Castilho Lopes, Vanessa da Silva Barros, Paulo Sergio Silva, Fábio Herget Pitanga, Liamara Basso Dala Costa, and Youssef Elias Ammar

Subjects
General Medicine
Abstract

Covid-19 is an infectious disease that causes inflammation in the respiratory system, is contagious and spreads rapidly. The sequelae caused after infection and treatment of Covid-19 are not fully known. The study aims to evaluate the quality of life and respiratory capacity of individuals who have been contaminated by the Covid-19 virus. This study is characterized as descriptive, with a cross-sectional design and a quantitative-qualitative approach. The sample consisted of 54 participants, of both sexes, diagnosed with Covid-19, who were hospitalized or not. Data collection was carried out through a mixed online questionnaire, developed on the Google Docs® platform. The results pointed to a worse quality of life in the domains Limitations due to physical aspects, Pain, Vitality, Limitations due to emotional aspects and a better quality of life for the domains Functional Capacity, General State of Health and Mental Health. And a worse quality of life assessed from the respiratory disease. It is concluded that the quality of life was affected and impaired after being affected by Covid-19 and that Physiotherapy helps to improve the sequelae and resumption of day-to-day activities, generating a good recovery.

Published
2022
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3. Relationship between Ischemic Stroke and Atrial Fibrillation, Systematic Review

Author

Cristianne Confessor Castilho Lopes

Subjects
Stroke, Cardiovascular diseases, Atrial fi brillation, Primary care
Abstract

Introduction:Atrial Fibrillation (AF) is not only one of the main causes of stroke, but it is also the most common sustained cardiac arrhythmia. As a result of population aging, an increase in the prevalence of AF and other associated chronic cardiovascular diseases, such as Systemic Arterial Hypertension (SAH) and Diabetes Mellitus (DM), is expected, contributing to a higher incidence of stroke. The magnitude of this fact reflects the reason why stroke is considered the second cause of death in the world, and the first cause of death in Brazil, in addition to being the second cause of cognitive losses. The main causes that favor the occurrence of ischemic stroke determine the situation of risk groups. Such factors can be classified as modifiable, non-modifiable and potential risk group. Objective:The aim of this study was to systematically review the public health literature on the relationship between ischemic stroke and atrial Fibrillation. Methods:Systematized literature review performed by searching the Web of Science database (Clarivates), Science Direct (Scopus), Wiley Online Library (John Wiley and Sons), Taylor and Francis (Taylor & Francis Group) and PubMed (NIH), using the descriptors Relationship between Ischemic Stroke and Atrial Fibrillation and other cardiovascular diseases in primary care, both in English and Portuguese. A total of 3860 articles were found, of which 64 were selected for the review by six evaluators independently. The articles surveyed are from the period 2015 to 2022. Results:In addition to the epidemiological magnitude, AF is important for its clinical consequences, including thromboembolic occurrences, with an increase, on average, of 4 times the probability of a stroke, in addition to being correlated with the high risk of all-cause mortality and other circumstantial determinants, such as heart failure. Conclusion: The analyzed studies demonstrated that there may be an adjusted incidence of ischemic stroke associated with AF and other cardiovascular diseases by stroke age, being age dependent in men. Social factors may contribute to the late discovery of the association between stroke, AF and other cardiovascular diseases.

Published
2023

4. Ischemic Stroke of Cardioembolic Origin - Systematic Review

Author

Cristianne Confessor Castilho Lopes

Subjects
Stroke, Cardioembolic vascular accident, Ischemic vascular accident
Abstract

Ischemic stroke corresponds to 80% of cases in Brazil, which demonstrates the epidemiological importance in Brazil. The magnitude of this fact reflects the reason why stroke is considered the second cause of death in the world, and the first cause of death in Brazil, in addition to being the second cause of cognitive losses. The main causes that favor the occurrence of ischemic stroke determine the situation of risk groups. Such factors can be classified as modifiable, non-modifiable and potential risk group.

Published
2023

5. Prevention of Melasma in Pregnant Women: Aspects of Approach in Aesthetic Treatment

Author

Cristianne Confessor Castilho Lopes

Subjects
Polymers and Plastics, General Environmental Science
Abstract

In the gestational period, several changes can occur in the woman's body, almost all the body's systems can undergo modifications, among them is the skin. One of the main changes that occur in the skin is melasma or pregnancy stain, which is the most common in the pigmentary changes of pregnancy. Hyperpigmentations are, in general, disorders distinguished by an increase in melanin and other pigments in the skin. The main triggers for the emergence of melasma are: sex hormones solar radiation and external agents, sources of free radicals. Melasma is characterized by irregularly shaped, brownish melanic pigmentation that appears mainly on the face, and may appear in the 1st or 2nd trimester of pregnancy, especially in women who are of childbearing age and also with phototypes IV and V. During pregnancy, the use of photoprotection correctly is essential for skin protection and to prevent the appearance of melasma, it is always recommended to use sunscreen daily, being applied 30 minutes before sun exposure and reapplying whenever necessary, avoiding the maximum sun exposure between the hours of 10 am to 4 pm. After pregnancy, there may be a large increase in hyperpigmentation, so some professionals indicate treatment after weaning, with some whitening substances such as glycolic acid, azelaic acid, and kojic acid, and can be associated with combined therapy, that is, in some cases, associate diamond pelling, which is a device with a sandpaper at the tip where it produces a sanding in the epidermis. , thus generating cell renewal. It is extremely important that pregnant women receive, at the beginning of pregnancy, all the information on prevention of melasma, and care with adequate photoprotection, thus avoiding psychological suffering and changes in their self-esteem.

Published
2022
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6. Relationship between Muscle Strength and Body Composition in Active Community Elderly

Author

Cristianne Confessor Castilho Lopes, Marilda Morais da Costa, Juliane Jesus Dos Santos, Antônio Vinicius Soares, Daniela dos Santos, Paulo Sérgio Silva, Tulio Gamio Dias, Eduardo Barbosa Lopes, Alessandra Novak, Laísa Zanatta, Vanessa da Silva Barros, Talitta Padilha Machado, Liamara Basso Dala Costa, Heliude de Quadros e Silva, and Youssef Elias Ammar

Subjects
Chemistry, Muscle strength, Composition (visual arts), Food science
Published
2021
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7. Analysis of physical therapy treatment in post-mastectomy sensitivity disorder

Author

Tatiane Caetano de Souza, Cristianne Confessor Castilho Lopes, Liamara Basso Dala Costa, Eduardo Barbosa Lopes, Laisa Zanatta, Youssef Elias Ammar, Marilda Morais da Costa, Daniela dos Santos, Tulio Gamio Dias, Vanessa da Silva Barros, Caroline Lehnen, Talitta Padilha Machado, Paulo Sérgio Silva, Joyce Kelly Busolin Jardim, Lucas Castilho Lopes, and Heliude de Quadros e Silva

Subjects
medicine.medical_specialty, business.industry, Post mastectomy, Medicine, Radiology, Sensitivity (control systems), business
Published
2021
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8. Relation between Age and Body Composition of Institutionalized Fragiles Elderly Women

Author

Stefany da Rocha Kaiser, Youssef Elias Ammar, Daniela dos Santos, Antônio Vinicius Soares, Heliude de Quadros e Silva, Cristianne Confessor Castilho Lopes, Paulo Sérgio Silva, Laisa Zanatta, Marilda Morais da Costa, Luís Fernando da Rosa, Eduardo Barbosa Lopes, Vanessa da Silva Barros, and Tulio Gamio Dias

Subjects
Relation (history of concept), Psychology, Composition (language), Demography
Published
2021
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9. Comparative Analysis of Covid-19 Cases in the World According to their Human Development Index (HDI)

Author

Laisa Zanatta, Marilda Morais da Costa, Eduardo Barbosa Lopes, João Vitor Freitas Bertuci, Lucas Castilho Lopes, Ana Paula de Oliveira Barbosa, Eliana Rezende Adami, Cristianne Confessor Castilho Lopes, Liamara Basso Dala Costa, Fabio KoppVanuzzi, Youssef Elias Ammar, Vanessa da Silva Barros, Daniela dos Santos, Tulio Gamio Dias, and Heliude de Quadros e Silva

Subjects
Geography, Coronavirus disease 2019 (COVID-19), Regional science, Human Development Index
Published
2021
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11. Quality of life and health profile in individuals with Parkinson's

Author

Joyce Kelly Busoli Jardim, Youssef Elias Ammar, Laisa Zanatta, Marilda Morais da Costa, Lucas Castilho Lopes, Thaine Andressa Ruschel, Liamara Basso Dala Costa, Daniela dos Santos, Tulio Gamio Dias, Vanessa da Silva Barros, Eduardo Barbosa Lopes, Cristianne Confessor Castilho Lopes, Heliude de Quadros e Silva, Paulo Sérgio Silva, and Caroline Lehnen

Subjects
Gerontology, Quality of life (healthcare), business.industry, Medicine, Health profile, business
Published
2021
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12. Preventive Respiratory Physiotherapy with Incentive in spirometer assistance in School Teachers EBI Adventist Education Center

Author

Marivane Lemos, Leonardo Felipe Meirelles Tenfen, Lucas Castilho Lopes, Eduardo Barbosa Lopes, Daniela dos Santos, Amanda Gallina, and Cristianne Confessor Castilho Lopes

Subjects
medicine.medical_specialty, Relaxation (psychology), business.industry, education, Cardiorespiratory fitness, law.invention, School teachers, Incentive, Breathing exercises, law, Physical therapy, Breathing, Medicine, Respiratory physiotherapy, business, Spirometer
Abstract

There are several factors that can cause us to have any disease, with those of the cardiorespiratory system is no different. They can arise by genetic inheritance, viroses and bacteria. Prevention in such cases is essential. Directly with the speech, the cardiorespiratory system of the teachers must be worked, be it of rehabilitative or preventive form. The objective of this work was to preempt the activities with respiratory exercises to strengthen and stretch the muscles responsible for breathing. Materials and methods: stretches, exercises, Respiron® and explanatory folders of how to perform the breathing exercises were used in a closed room with a maximum of 5 teachers at a time, so that there was relaxation. Results: The entire group of teachers performed the exercises, and they reported that there was a significant decrease in stress in the classroom, and improved sleep. Conclusion: it was concluded that with the exercises and stretches, the improvement occurred in the cardiorespiratory system, in the quality of life, as well as in the classroom.

Published
2020
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13. Risk Factors and Sociodemographic Characteristics of Ischemic Stroke in Brazil – A Systematic Review

Author

Youssef Elias Ammar, Viviane Dorgievicz, Marivane Lemos, Vanessa da Silva Barros, Lucas Castilho Lopes, Norberto Luiz Cabral, Marcelo Pitombeira de Lacerda, Paulo Henrique Condeixa de França, Heliude de Quadros, Cristianne Confessor Castilho Lopes, Daniela dos Santos, Eduardo Barbosa Lopes, and Paulo Sérgio Silva

Subjects
medicine.medical_specialty, business.industry, Emergency medicine, Ischemic stroke, medicine, business
Published
2020
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15. Alicerces e Adversidades das Ciências da Saúde no Brasil 2

Author

Yolanda Gomes Duarte, Jocelio Matos Amaral, Katianne Wanderley Rocha, Eduarda Correia Dos Santos, Marília Cunha Maroneze, Janayle Kéllen Duarte De Sales, Cristiane Silva De Oliveira, Milena Silva Costa, Renata Vilar Bernardo, Martina Caroline Stapenhorst, Mauro Mccarthy De Oliveira Silva, Daiane Dal Pai, Suelen Marçal Nogueira, Renata Da Rocha Soares Leão, Rachel De Sá Barreto Luna Callou Cruz, Angelica Nakamura, Eguimara De Souza Borges Fernandes, Fellipe Batista De Oliveira, Tainá Araújo Rocha, Paloma De Souza Melo, Tamyris Pinheiro Gouveia, Willma José De Santana, Lairton Batista De Oliveira, Israel Sobreira Machado, Gabrielle Cavalcante Barbosa Lopes, Raphaela Farias Teixeira, Lorena Alencar Sousa, Camila Amato Montalbano, Letícia Barbieri Caus, Maria Da Consolação Pitanga De Sousa, Paula Suene Pereira Dos Santos, Natácia Élem Felix Silva, Chancarlyne Vivian, Joilane Alves Pereira Freire, Matheus Dos Santos Coelho, Brunna Rafaella Do Carmo Silva, Deyna Francélia Andrade Próspero, Monalisa Salgado Bittar, Aliéren Honório Oliveira, Milena D’Avila Nascimento Barbosa, Iannaele Oliveira Do Vale Batista, Raíssa Oliveira De Almeida, Grazielle Aurelina Fraga De Sousa, Karluza Araújo Moreira Dantas, Thereza Maria Magalhães Moreira, Maria Auxiliadora Macedo Callou, Mônica De Oliveira Santos, Luciano Moreira Alencar, Gabriel Henrique De Souza Silva, Sara Pinto Teixeira, Christofer Da Silva Christofoli, Ozeias Pereira De Oliveira, Thayane Gomes De Almeida, Ana Beatriz Linard De Carvalho, Manuele Miranda Mafra Oliveira, Rubens Alex De Oliveira Menezes, Gelbcke Félix Nogueira, Viviane Da Silva Alves, Giovanna Carello Collar, Heloiza Dias Lopes Lago, Antonia Samara Pedrosa De Lima, Dalmo De Santana Simões, Kênia Alves Barcelos, Francisco Leonardo Da Silva Feitosa, Mauricio Avelar Fernandes, Lucas Cadmio Silveira Loureiro, Sobia Kanwal, Lindiane Lopes De Souza, Maria Aparecida Nunes De Carvalho, Gefersson Matias De Lima Silva, Claudenisia De Freitas Lima Andrade, Sara Beatriz Feitoza Ricardino, Tereza D’Ávila De Araújo Gomes Silva, Fabiana Ferreira Koopmans, José Edson Ferreira Da Costa, Ana Cristina Da Silva Pinto, Grasiele Fatima Busnello, Ranilde Cristiane Cavalcante Costa, Ilka Kassandra Pereira Belfort, Cinthia Kelly Campos Sabadini, Kethelyn Nayara De Almeida Pereira, Joanderson Nunes Cardoso, Mariana Nóbrega Marcon, Silvio Leonardo Nunes De Oliveira, Athanara Alves De Sousa, Yaskara Santos Lôbo, Néliton Da Costa Silva, Andréa Couto Feitosa, Carmen Weber Dalazen, Edilma Gomes Rocha Cavalcante, Aline Tenório Lins Carnaúba, Luzianne Clemente De Meneses, Tatiana Do Socorro Dos Santos Calandrini, Sammara Luizza De Oliveira Costa, Wochimann De Melo Lima Pinto, Ana Paula Ribeiro De Castro, Paula Rayanne Amorim Correia, Franc-Lane Sousa Carvalho Do Nascimento, Tamiris Ramos Silva, Crystianne Samara Barbosa Araújo, Deise Cristina Pereira De Oliveira, Cicera Emanuele Do Monte Simão, Maria Do Socorro Da Silva, Isabelly Rayane Alves Dos Santos, Marlene Gomes De Farias, Maria Joseneide De Sousa Santiago, Klinger Vagner Teixeira Da Costa, Matheus Araújo Medeiros, Lorrany Terezinha Oliveira De Souza, Mariane Camila Da Silveira, Mira Raya Paula De Lima, Bárbara Rocha Lima Mello, Ilza Iris Dos Santos, Rayanne De Sousa Barbosa, Francielton De Amorim Marçal, Maria Elisa Regina Benjamin De Moura, Fernanda Calheiros Peixoto Tenório, Cid Gonzaga Gomes, Herta Gonçalves Parente Pinheiro Teles, Daniela Dos Santos, Maria Fernanda Larcher De Almeida, Antonio Alberto Ibiapina Costa Filho, Natália Carvalho Barros Franco, Thaynara Cristina Oliveira Braga Gonçalves, Paloma Soares Dos Santos, Helder Matheus Alves Fernandes, Patrícia Pasquali Dotto, Eduardo Barbosa Lopes, Vânia Terezinha Rigo Segalin, Francisca Alessandra Lima Da Silva, Mônica Maria Siqueira Damasceno, Ricardo Souza Heinzelmann, Rosana Cabral Pinheiro, Eduarda Brennda Ferreira Gonçalves De Lima, Maria Aparecida Muniz Farias, Clarissa Cotrim Dos Anjos, Graciano Almeida Sudré, Wanessa Alves Carneiro Azevedo De Lima, Mariangela Braga Pereira Nielsen, Bruna Araujo De Menezes, Régila Santos Pinheiro, Ana Carla Gomes Canário, Eliane Maria Fleury Seidl, Ticyanne Soares Barros, Guilherme Pioli Resende, Kelly Cristina Lira De Andrade, Carliana Kattwlly Oliveira, Maria Naqve, Denise De Souza Ribeiro, José Erivan Lima De Carvalho, Thaís Rodrigues De Albuquerque, Fabiana Pereira Da Silva, Janaina Farias Rebouças, Emanuel Messias Silva Feitosa, Rafael Mondego Fontenele, Carlos Vinícius Moreira Lima, Simone D' Ambros, Kelly Ferreira, Janice Alves Trajano, Irani Rodrigues Maldonade, Valdênia Guimarães E Silva Menegon, Andressa Karina Leitão Da Encarnação, Rosane De Almeida Andrade, Liane Beatriz Righi, Maria Eduarda Correia Dos Santos, Arthur Wagner Da Silva Rodrigues, Priscyla Tavares Almeida, Thaís Nobre Uchôa Souza, Natália Dos Santos Almeida, Murilo Marques Costa, Renata Sampaio Rodrigues Soutinho, Rafael De Carvalho Mendes, Lucas Santana, Juliana Ariádina De Vasconcelos, Igor Lucas Figueredo De Melo, Thainá Emí Barreto Gomes, Taline Alves Nobre, Beatriz Da Silva Nicácio, Nirlande Rodrigues Da Silva, Vitória De Oliveira Batista, Silmara Alves De Souza, João Vitor De Andrade Barreto Lopes, Janainna Maria Maia, Rose Daiana Cunha Dos Santos, Renata Evaristo Rodrigues Da Silva, Kaienat Asghar Ali, José Alexandre Alves Do Nascimento, Danilo De Sousa Rodrigues, José Roberto Jordão Rodrigues, Sandra Adriana Zimpel, Izadora Soares Pedro Macêdo, Maria Alyne Lima Dos Santos, Ágna Retyelly Sampaio De Souza, João Matheus Ferreira Do Nascimento, Ana Karênina Sá Fernandes, Cicero Rafael Lopes Da Silva, Ronizia Ramalho Almeida, Ágata De Vargas Dupont, Ana Cibele Pereira Sousa, Aroldo Vieira De Moraes Filho, Lucio Mauro Braga Machado, Mabel Maria Sousa Figueiredo, Ítalo Colaço De Souza, Ana Patrícia Fonseca Coelho Galvão, Ayrton Silva Brito, João Pedro Ferrari Souza, Luciana Carrupt Machado Sogame, Míriam Silva Rafael, Bárbara Mariño Dal Magro, Lya Raquel Oliveira Dos Santos, Amarildo Canevaroli Júnior, Itamara Da Costa Sousa, Victor Hamilton Da Silva Freitas, Letícia De Lima Trindade, Elga Gering, Diana Alves Ferreira, Amanda Cristina Araújo Cavalcante, Genaína Alves De Oliveira, Francisco Elves De Lima Silva, Marcilene Barbosa De Oliveira Dos Santos, Helenicy Nogueira Holanda Veras, Janaina Patrocinio De Souza, Josivaldo Macêdo Silva, Francisco Ronaldo Caliman Filho, Rivaldo Venâncio Da Cunha, Fabiane Pertille, Ivana Paula Ferraz De Andrade, Breno De Oliveira Ferreira, Adriana Sousa Carvalho De Aguiar, Mary Lee Dos Santos, Adriana Bos-Mikich, Rejane Ferreira Da Silva, Karoline Feitosa Sobreira, Letícia Briany De Carvalho Lessa, Camila Maria Do Nascimento, Carolina Fajardo Valente Pagliarin Brüggemann, Clemilson Da Silva Barros, Karina Morais Borges, Isadora Almeida De Sousa, Edirlene De Melo Nogueira, Marília Costa Cavalcante, Lany Leide De Castro Rocha Campelo, Cicera Leticia Da Silva, Amanda Gallina, Pedro De Lemos Menezes, Mônica Santiago Barbosa, Ariana Teresa Mateus Ventura, Cícero Bruno Moura De Souza, Cícera Janielly De Matos Cassiano Pinheiro, Leonardo Coelho Rodrigues, Mariza Aparecida Alves Araújo, Alyce Brito Barros, Maria Larissa De Oliveira, Gabriella Gonçalves Feitosa, Pamella Rosena De Oliveira Mota, Maria Rute Gonçalves Moraes, Virgínia Gadelha Dos Santos, Luciana Castelo Branco Camurça Fernandes, Ingrid Lima Felix De Carvalho, Luiz Carlos Soares Marcelino, Ana Luiza Caldeira, Fabiana De Souza, Katriny Guimarães Couto, Dayanne Rakelly De Oliveira, Diêgo De Oliveira Lima, Flávia Vitória Pereira De Moura, Emanuel Osvaldo De Sousa, Romero Sales Frazão, Beatriz Araujo Dos Santos, Karen Soares Trinta, Izabel Cristina Bruno Bacellar Zaneti, Lara Anísia Menezes Bonates, Paulo Germano Sousa, Diogo Henrique Meneguelli, Paloma Ingrid Dos Santos, Elane Da Silva Barbosa, Maria Leni Alves Silva, Edison Luis Santana Carvalho, Daniel Luís Viana Cruz, Flávia Sonaria Da Silva, Pallysson Paulo Da Silva, Korina Maria Cappelletti Cardoso, Joseline Pereira Lima, Rosilane Da Silva Soares, Adnan Malik, Marina Gonçalves Assis, Diego Ravelly Dos Santos Callou, Nely Dayse Santos Da Mata, Sarah Isabela Magalhães Costa, Michel Vergne Félix Sucupira, Andréa Rose De Albuquerque Sarmento-Omena, Anderson Ramom Amaral Leite, Eduardo Duarte Machado, Uilna Natercia Soares Feitosa, Carla Afonso Da Silva Bitencourt Braga, Cícero Johnny Alves Mota, Marcella Dias Mazolini Mendes, Rosana Oliveira Do Nascimento, Patricia Riddell Millar, Menandes Alves De Souza Neto, Sílvia Furtado De Barros, Cleiber Marcio Flores, Nathalia Aiello Montoro, Mayara Fernandes Pereira, Ana Amália Gomes De Barros Torres Faria, João Paulo Duarte Witusk, Daiana Brancalione, Sarah Brena Aparecida Rosa, Edna Regina Silva Pereira, Josi Nunes Barreto, Priscilla Inocêncio Rodrigues Ribeiro, Diogo Magalhães Da Costa Galdino, Cristianne Confessor Castilho Lopes, Simone Soares Damasceno, Ydléia Félix Dos Santos, Mariana Mendes, Liana De Andrade Esmeraldo Pereira, Victor Hugo Oliveira Brito, Guthierris Luciano Alves, Cíntia Maria De Melo Mendes, Eveline Naiara Nuvens Oliveira, Jeane Lima Cavalcante, Danielle Silva Araújo, Cláudio Silva Teixeira, Suelen Rayanne Moreira Da Silva, Luis Rafael Leite Sampaio, Ana Luiza Rodrigues Santos, Ali Raza, Bruno Pinheiro Maximo, João Oliveira Alves, Gilberto Dos Santos Dias De Sousa, Daisy Machado, Leonardo Ferreira Silva, Hernágila Costa Freitas, Viviane Moreira Dos Santos Teixeira, Laiz Aparecida Azevedo Silva, Hanyelle Felix Cruz Landim, José Gerlucio Da Silva Morais, Cosmo Alexandro Da Silva De Aguiar, Nathalia Marques Santos, Renata Sousa Nunes, Emanuela Machado Silva Saraiva, Edina Silva Costa, Isabelle Cabral De Oliveira, Leticia Gomes De Pontes, Lilandra Mauryele Chaves, Heloísa Ribeiro Alves, Cristhiane Nathália Pontes De Oliveira, Katiele Hundertmarck, Aline Carla Araújo Carvalho, Eugenia Leopoldina Ferreira, Lucas Castilho Lopes, Janaína Carneiro Lima, Mayane Fiorot Simoni, Danilo Ferreira De Sousa, Vitória Alves De Moura, Fernanda Antônia De Albuquerque Melo, Janielle Cardoso Da Silva, Deborah Santana Pereira, Renata Brito Souza, Monyka Brito Lima Dos Santos, Francisca Thamilis Pereira Da Silva, João Lucas De Sena Cavalcante, Crystianne Samara Barbosa De Araújo, Conceição De Maria Lima Nascimento, Danilo Bastos Moreno, Maryam Liaqat, Bárbara Maciel De Pinho, Alex Miranda Rodrigues, Paulo Cilas De Carvalho Sousa, Emanuella Rodrigues Coelho, Olguimar Pereira Ivo, Ana Paula Cardoso Costa, Francisco Douglas Dias Barros, Shaukat Ali Shahid, Laís Lobo Pereira, Marislene Pulsena Da Cunha Nunes, Giselle Carvalho Maia, Narcélio Pinheiro Victor, Ana Paula Ribeiro Castro, Raízza Barbosa Elói Mendes, Cristian Souza Freitas, Leyla Andrade Barbosa, Thais Jessica Dos Santos Clementino, Glauce Albuquerque Alencar, Francisco Rodrigo Silva, Chesla De Alencar Ribeiro, Paulo Francisco De Almeida Neto, Saher Jabeen, Benedita Célia Leão Gomes, Edglê Pedro De Sousa Filho, Raimundo Monteiro Da Silva Neto, Mayara De Alencar Amorim, Meykson Alexandre Da Silva, Luzilena De Sousa Prudêncio, Elisângela Oliveira Da Silva, Messias Gomes Filho, Luana Cristina Rodrigues Venceslau, Mayara Dias De Araujo, Hercules Pereira Coelho, Jorge Costa Neto, Raquel Silva De Souza, Dennis Rodrigues De Sousa, Bruna Martins Nogueira Leal, Anna Karoline Pereira Macêdo, Ramiza Ali, Matheus Marques Da Silva Leite, Karine Guiot Araújo, Aline Raquel De Sousa Ibiapina, Gilberto Dolejal Zanetti, Rita Cristina Azevedo Martins, Daniele Cristina Alves Fernandes, Jackeline Kérollen Duarte De Sales, Rayane Silva Alves, Ana Maria Machado Borges, Wanderson Alves Martins, Cícera Dos Santos Moura, Marla Brenda Pires Coimbra, Juliana Rodrigues Da Silva, Emanuel Belarmino Dos Santos, José Leonardo Gomes Coelho, Sally Cristina Moutinho Monteiro, Karine Nascimento Da Silva, Cicera Thanise Pereira Alves, Elcilene Fernandes Da Silva Pereira, Maria Regina Reis Amendoeira, Juliana Maria Da Silva, Jordanna Mirelle Carvalho Pardinho, André Luís Do Nascimento Mont’ Alverne, Elvis Alves Oliveira, Karoline Cordeiro Silva, Cicera Ariane Rodrigues Bezerra, Maria Eugênia Novais De Araújo, Aldeiza Almeida Barros, Manoela Marciane Calderan, Márcia Jaínne Campelo Chaves, Ana Cristina De Almeida, Jesyskelly Duarte Dos Santos Tenório, Maria Jeanne De Alencar Tavares, Maria Do Desterro Da Costa E Silva, Karoliny Miranda Barata, Karolyn Oane Araújo Medeiros, Jane De Carlos Santana Capelli, Vithória Régia Teixeira Rodrigues, Maria Clara Feijó De Figueiredo, Micheline Keila De Oliveira Ferreira, Meyrian Luana Teles De Sousa Luz Soares, and Joseane Ferreira Parente

Published
2019
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17. PB2120 THE IMPACT OF DEPTH OF RESPONSE BEFORE AND AFTER AUTOLOGOUS STEM CELL TRANSPLANT FOR MULTIPLE MYELOMA PATIENTS

Author

Raul Moreno, Graça Esteves, Helena Martins, Ana C. Alho, F. Lourenço, Blanca Polo, Conceição Garcia Martins, Joana Brioso Infante, S. Durão, João Raposo, Cristianne Confessor Castilho Lopes, Eduardo Espada, Joana Vieira, Manuel Neves, Maria Joao Costa, F. Velosa, J. Forjaz Lacerda, Sara Valle, and Daniela Alves

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, medicine, Hematology, Stem cell, medicine.disease, business, Multiple myeloma
Published
2019
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18. Estrogens Metabolism Associated with Polymorphisms: Influence of COMT G482a Genotype on Age at Onset of Canine Mammary Tumors

Author

P. Dias Pereira, Cristianne Confessor Castilho Lopes, A.J.F. Matos, Rui Medeiros, Célia Lopes, Daniela Pinto, and Fátima Gärtner

Subjects
medicine.medical_specialty, Genotype, Mammary Neoplasms, Animal, Single-nucleotide polymorphism, Kaplan-Meier Estimate, Catechol O-Methyltransferase, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Dogs, Breast cancer, Internal medicine, medicine, Animals, Genetic Predisposition to Disease, Dog Diseases, Age of Onset, Allele, Alleles, Mammary tumor, General Veterinary, business.industry, Case-control study, DNA, medicine.disease, Estrogens, Catechol, Endocrinology, Case-Control Studies, Female, Gene polymorphism, Age of onset, business
Abstract

Catechol-O-methyltransferase (COMT) is an important enzyme participating in inactivation of carcinogenic oestrogen metabolites. In humans there is a single nucleotide polymorphism in COMT gene (COMT va1158met) that has been associated with an increased risk for developing breast cancer. In dogs, there is a single nucleotide polymorphism in COMT gene (G482A), but its relation with mammary carcinogenesis has never been investigated. The aim of this study was to focus on the evaluation of such polymorphism as a risk factor for the development of mammary tumors in bitches and on the analysis of its relationship with some clinicopathologic features (dog's age and weight, number and histologic type of the lesions, lymph node metastasis) of canine mammary neoplasms. A case-control study was conducted analyzing 90 bitches with mammary tumors and 84 bitches without evidence of neoplastic disease. The COMT G482A polymorphism was analyzed by PCR-RFLP. We found a protective effect of the polymorphism in age of onset of mammary tumors, although we could not establish a significant association between COMT genotype and other clinicopathologic parameters nor with mammary tumor risk overall. Animals carrying the variant allele have a threefold likelihood of developing mammary tumors after 9 years of age in comparison with noncarriers. The Kaplan-Meier method revealed significant differences in the waiting time for onset of malignant disease for A allele carrier (12.46 years) and noncarrier (11.13 years) animals. This investigation constitutes the first case-control study designed to assess the relationship between polymorphic genes and mammary tumor risk in dogs. Our results point to the combined effect of COMT genotype with other genetic and/or environmental risk factors as important key factors for mammary tumor etiopathogenesis.

Published
2008
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19. E-cadherin expression in canine malignant mammary tumours: relationship to other clinico-pathological variables

Author

Fátima Gärtner, Gerard R. Rutteman, M. Santos, Júlio Carvalheira, A.J.F. Matos, Cristianne Confessor Castilho Lopes, Tissue Repair, and Geneeskunde van gezelschapsdieren

Subjects
Pathology, medicine.medical_specialty, Poor prognosis, Necrosis, Mammary Neoplasms, Animal, Malignancy, Pathology and Forensic Medicine, Infiltrative Growth, Immunoenzyme Techniques, Dogs, Mammary Glands, Animal, Carcinosarcoma, medicine, Biomarkers, Tumor, Animals, Fixation (histology), Neoplasm Staging, General Veterinary, Cadherin, business.industry, Carcinoma, medicine.disease, Cadherins, Lymphatic Metastasis, Immunohistochemistry, Clinico pathological, Female, Lymph Nodes, medicine.symptom, business
Abstract

The relationship between E-cadherin epithelial expression, as detected by immunohistochemical methods, and other clinico-pathological characteristics of canine malignant mammary tumours was studied in 77 tumours surgically removed from 45 female dogs. The immunohistochemical assessment was based on the estimated percentage of epithelial cells with membranous labelling. Reduction of E-cadherin expression was significantly related to size and ulceration of tumours but not to fixation to skin or underlying tissue; it was also related to lymph node metastasis, necrosis and infiltrative growth. Histological type (but not histological grade) was related to E-cadherin expression, with solid tumours more frequently lacking expression and tubulopapillary tumours showing increased expression as compared with the other types. The significant relationship between E-cadherin and other known factors of poor prognosis suggests that the loss of E-cadherin expression may have prognostic value in canine malignant mammary tumours.

Published
2005

20. Iron (De)Regulation in Breast Cancer: a Role for Stromal Inflammatory Cells in the Tumor Microenvironment

Author

Alexandra Rêma, Fátima Faria, Cristianne Confessor Castilho Lopes, Geciane Silveira Porto, B M da Silva, Oriana Marques, and J. E. B. P. Pinto

Subjects
Tumor microenvironment, Stromal cell, Breast cancer, Oncology, business.industry, Inflammatory cell, Cancer research, De regulation, Medicine, Social role, Hematology, business, medicine.disease
Published
2014
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