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El desarrollo minero en Cuba es de vital importancia para el desarrollo del país, aunque ha generado pasivos ambientales producto de la incorrecta ejecución del plan de Cierre de Minas; entre las causas que se plantea se encuentran la falta de financiamiento para enfrentar este proceso. El propósito de este trabajo fue desarrollar una política contable para la creación y utilización de una provisión por cierre de minas lo que garantizará al concluir el ciclo de vida del proyecto minero, que las empresas cuenten con el financiamiento necesario para ejecutar el plan de cierre.

BackgroundSeveral single-site alcohol treatment clinical trials have demonstrated efficacy for immediate-release (IR) gabapentin in reducing drinking outcomes among individuals with alcohol dependence. The purpose of this study was to conduct a large, multisite clinical trial of gabapentin enacarbil extended-release (GE-XR) (HORIZANT® ), a gabapentin prodrug formulation, to determine its safety and efficacy in treating alcohol use disorder (AUD).MethodsMen and women (n = 346) who met DSM-5 criteria for at least moderate AUD were recruited across 10 U.S. clinical sites. Participants received double-blind GE-XR (600 mg twice a day) or placebo and a computerized behavioral intervention (Take Control) for 6 months. Efficacy analyses were prespecified for the last 4 weeks of the treatment period.ResultsThe GE-XR and placebo groups did not differ significantly on the primary outcome measure, percentage of subjects with no heavy drinking days (28.3 vs. 21.5, respectively, p = 0.157). Similarly, no clinical benefit was found for other drinking measures (percent subjects abstinent, percent days abstinent, percent heavy drinking days, drinks per week, drinks per drinking day), alcohol craving, alcohol-related consequences, sleep problems, smoking, and depression/anxiety symptoms. Common side-effects were fatigue, dizziness, and somnolence. A population pharmacokinetics analysis revealed that patients had lower gabapentin exposure levels compared with those in other studies using a similar dose but for other indications.ConclusionsOverall, GE-XR at 600 mg twice a day did not reduce alcohol consumption or craving in individuals with AUD. It is possible that, unlike the IR formulation of gabapentin, which showed efficacy in smaller Phase 2 trials at a higher dose, GE-XR is not effective in treating AUD, at least not at doses approved by the U.S. Food and Drug Administration for treating other medical conditions.

Brazil, the world's largest soybean producer, owes its success to the cultivation of glyphosate-resistant (GR) cultivars. However, the soybean yields lag behind those obtained in areas managed for high productivity. Glyphosate-induced hormesis holds promise for increasing crop yields, but the potential evolution of resistance in certain weed species poses a challenge to foliar applications under field conditions. This study assessed the effects of a hormesis-inducing glyphosate dose [90 g acid equivalent (ae) ha−1] on the agronomic characteristics and yield of four GR soybean cultivars. The evaluation was conducted in field settings across various Brazilian locations, considering foliar, seed, and seed + foliar treatments. The results showed variations in dry mass, root nodules, nutrient composition, plant height, pods, and yield, primarily influenced by environmental conditions, soil quality, and, ultimately, the interaction between GR cultivars and treatments. Total dry mass consistently increased with glyphosate, with seed and seed + foliar treatments showing the most substantial increases (7–21%). All three treatments increased nodulation by up to 36% across locations and cultivars, with seed + foliar treatment causing notable increases in nodule dry mass (up to 56%), followed by seed treatment (41%). Nutrient composition, especially for N, P, Br, and Fe, displayed location-dependent variations. Plant height varied among locations and cultivars, with minimal differences between treatments. Glyphosate treatments increased pod numbers (10 to 35%) and yields (11 to 42%) of soybean in seed and seed + foliar treatments. The findings highlight the potential of glyphosate hormesis as a viable tool for improving yields of GR soybean cultivars at the field level. However, the extent of benefits depends on the agronomic conditions of location, choice of cultivars, and herbicide application method. [ABSTRACT FROM AUTHOR]

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La industria 4.0 está relacionada en cada lugar y con el uso y la implementación de nuevas tecnologías para la mejora continua de los procesos administrativos. Como parte del crecimiento de una organización, es importante que día a día se adapte a los cambios tecnológicos que afectan las operaciones de los trabajadores o la seguridad laboral. Algunos de los elementos que abarca esta industria son el uso de equipos autónomos, robótica, simuladores de procesos, impresoras 3D, inteligencia artificial y equipos que comparten información en tiempo real. El objetivo de este artículo consiste en valorar los procesos de digitalización de las organizaciones de la ciudad de Tampico, Tamaulipas (México), desde el punto de vista del usuario, para identificar los factores determinantes de la satisfacción laboral. Se emplea la técnica multivariante de regresión de mínimos cuadrados parciales, considerando como factores de análisis de digitalización y su relación con el modelo de relación y colaboración, habilidades y competencias profesionales, formación digital y procesos de digitalización. Los resultados muestran que el grado de motivación aumenta con el incremento en la digitalización de los procesos y que la formación digital y las competencias profesionales necesitan aumentar gradualmente para tener un impacto positivo en relación con los procesos de digitalización. || Industry 4.0 is related in each place and with the use and implementation of new technologies for the continuous improvement of administrative processes. As part of the growth of an organization, it is important that day by day it adapts to technological changes that affect worker operations or job security. Some of the elements that this industry encompasses are the use of autonomous equipment, robotics, process simulators, 3D printers, artificial intelligence and equipment that share information in real time. The objective of this article is to assess the digitization processes of organizations in the city of Tampico, Tamaulipas (Mexico), from the user's point of view, to identify the determining factors of job satisfaction. The multivariate technique of partial least squares regression (or PLS, by Partial Least Squares (or SEM, by Structural Equation Models) is used, considering as digitization analysis factors and their relationship with the relationship and collaboration model, skills and competencies professionals, digital training and digitization processes. The results show that the degree of motivation increases with the increase in the digitization of processes and that digital training and professional competencies need to increase gradually to have a positive impact in relation to the processes of digitization.

Straw from no-till cropping systems, in addition to increasing the soil organic matter content, may also impede the movement of applied herbicides into the soil and, thus, alter the behavior and fate of these compounds in the environment. Rain or irrigation before or after an herbicide treatment can either help or hinder its movement through the straw, influencing weed control. Our objective was to develop a system for herbicide application and rain simulation, enabling the evaluation of the movement of various herbicides either in dry or wet straw under different rainfall volumes (25, 50, 75, and 100 mm). The amount of the applied herbicides that moved through the straw were collected and measured using a liquid chromatograph with a tandem mass spectrometry system (LC-MS/MS). Measurements obtained with the developed system showed a high herbicide treatment uniformity across all replications. The movement of the active ingredients through the straw showed variability that was a function of the applied herbicide, ranging from 17% to 99%. In wet straw, the collected herbicide remained constant from 50 to 100 mm of simulated rainfall. For the wet straw, the decreasing percentages of the herbicide movement through straw to the soil were sulfentrazone (99%), atrazine and diuron (91% each), hexazinone (84%), fomesafen (80.4%), indaziflam (79%), glyphosate (63%), haloxyfop-p-methyl (45%), and S-metolachlor (27%). On the dry straw, the decreasing percentages of the herbicide movement were fomesafen (88%), sulfentrazone (74%), atrazine (69.4%), hexazinone (69%), diuron (68.4%), glyphosate (48%), indaziflam (34.4%), S-metolachlor (22%), and haloxyfop-p-methyl (18%). Overall, herbicide movement was higher in wet straw (with a previous 25 mm simulated rainfall layer) than in dry straw. Some herbicides, like haloxyfop-p-methyl and indaziflam, exhibited over 50% higher movement in wet straw than dry straw after 100 mm of simulated rain. The developed system can be adapted for various uses, serving as a valuable tool to evaluate the behavior of hazardous substances in different agricultural and environmental scenarios. [ABSTRACT FROM AUTHOR]

El trabajo recoge la propuesta de armonización de la norma de información financiera sobre Exploración y Evaluación de los recursos minerales, atemperada a las características de la economía cubana.

Recent discoveries of at least two heart fields and dynamic nature of cardiac development as well as controversies regarding the participation of heart fields in development of different heart structures led us to investigate the dynamics of incorporation of the first and second heart fields and prospective fate of the straight heart tube by labeling chicken embryos in vivo with the fluorescent lipophilic dye DiI. The cephalic and caudal limits of the anterior and posterior segments of the straight heart tube were labeled in two groups of embryos. Labels were tracked along the "C," "S," and "U" loops up to the tetracavitary or mature heart (n = 30 embryos/group; torsion and looping stage). To determine whether the atria and atrioventricular canal are derived from the first heart field the straight heart tube was cultured in vitro and immunodetection of Sox-9 and troponin I was performed to identify the mesenchymal and myocardial lineages respectively. Proliferating cell nuclear antigen (PCNA) immunodetection was used to determine the involvement of cell proliferation in heart tube development during torsion and looping. Embryological constitution of the straight heart tube and heart looping (C, S, and U) were not consistent with current descriptions. In fact, right ventricle precursors were absent in the straight heart tube derived from the first heart field. During torsion and looping, the cephalic segment of the straight heart tube gradually shifted into the heart tube until it was located at the myocardial interventricular septum in the tetracavitary heart. In contrast, the caudal segment of the straight heart tube was elongated and remodeled to become the first heart field derived left ventricle and the proximal part of the ventricular inlets. The ventricular outflows, right ventricle, distal part of the ventricular inlets, and atria developed from the second heart field.