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3. Long-Term Results of Tinnitus Retraining Therapy in Patients Who Failed to Complete the Program.

Author

Lapenn, Ruggero, Molini, Egisto, Cipriani, Laura, Del Zompo, Maria Rita, Giommett, Giorgia, Faralli, Mario, and Ricci, Giampietro

Subjects
TINNITUS, OCCUPATIONAL retraining, TELEPHONE surveys, COUNSELING, QUESTIONNAIRES
Abstract

Purpose: We aimed to evaluate the results of Tinnitus Retraining Therapy (TRT) in patients who did not complete the program. Methods: We divided 9Q patients who failed to complete the TRT program were into 3 groups: 36 patients who only completed the first phase of the TRT program (Missing group; M), 34 patients who attended counselling for less than 6 months (Noncompliant group; NC) and 2Q patients who attended counselling for more than 6 months but did not complete the TRT program (Compliant group; C). The Tinnitus Handicap Inventory (THI), tinnitus Visual Analogue Scales (VAS) and a questionnaire regarding the reasons for dropout were obtained through a telephone survey. Results: Telephonic THI and VAS scores were significantly lower than the initial scores in the M and C groups but not in the NC group. Patients who were unsure about the effectiveness of TRT were prevalent in the NC group, and the poorest long-term THI results were registered in those patients. Conclusions: A fundamental cause of very poor TRT results was when patients were unsure about TRT. On the other hand, a single counselling session could be effective in reducing tinnitus annoyance in patients who accepted the TRT approach and trusted its efficacy. [ABSTRACT FROM AUTHOR]

Published
2021
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4. Shared genetic contribution to ischemic stroke and Alzheimer's disease

Author

Traylor, Matthew, Adib Samii, Poneh, Harold, Denise, Dichgans, Martin, Williams, Julie, Lewis, Cathryn M., Markus, Hugh S., Fornage, Myriam, Holliday, Elizabeth G., Sharma, Pankaj, Bis, Joshua C., Psaty, Bruce M., Seshadri, Sudha, Nalls, Mike A., Devan, William J., Boncoraglio, Giorgio, Malik, Rainer, Mitchell, Braxton D., Kittner, Steven J., Ikram, M. Arfan, Clarke, Robert, Rosand, Jonathan, Meschia, James F., Sudlow, Cathie, Rothwell, Peter M., Levi, Christopher, Bevan, Steve, Kilarski, Laura L., Walters, Matthew, Thijs, Vincent, Slowik, Agnieszka, Lindgren, Arne, De Bakker, Paul I. W., Lambert, Jean Charles, Ibrahim Verbaas, Carla A., Naj, Adam C., Sims, Rebecca, Bellenguez, Céline, Jun, Gyungah, Destefano, Anita L., Beecham, Gary W., Grenier Boley, Benjamin, Russo, Giancarlo, Thornton Wells, Tricia A., Jones, Nicola, Smith, Albert V., Chouraki, Vincent, Thomas, Charlene, Zelenika, Diana, Vardarajan, Badri N., Kamatani, Yoichiro, Lin, Chiao Feng, Gerrish, Amy, Schmidt, Helena, Kunkle, Brian, Dunstan, Melanie L., Ruiz, Agustin, Bihoreau, Marie Thçrèse, Choi, Seung Hoan, Reitz, Christiane, Pasquier, Florence, Hollingworth, Paul, Ramirez, Alfredo, Hanon, Olivier, Fitzpatrick, Annette L, Buxbaum, Joseph D, Campion, Dominique, Crane, Paul K, Baldwin, Clinton, Becker, Tim, Gudnason, Vilmundur, Cruchaga, Carlos, Craig, David, Amin, Najaf, Berr, Claudine, Lopez, Oscar L, De Jager, Philip L, Deramecourt, Vincent, Johnston, Janet A, Evans, Denis, Lovestone, Simon, Letenneur, Luc, Morón, Francisco J, Rubinsztein, David C, Eiriksdottir, Gudny, Sleegers, Kristel, Goate, Alison M, Fiçvet, Nathalie, Huentelman, Matthew J, Gill, Michael, Brown, Kristelle, Kamboh, M. Ilyas, Keller, Lina, Barberger Gateau, Pascale, Mcguinness, Bernadette, Larson, Eric B, Green, Robert, Myers, Amanda J, Dufouil, Carole, Todd, Stephen, Wallon, David, Love, Seth, Rogaeva, Ekaterina, Gallacher, John, St George Hyslop, Peter, Clarimon, Jordi, Lleo, Alberto, Bayer, Anthony, Tsuang, Debby W, Lei, Yu, Tsolaki, Magda, Bossù, Paola, Spalletta, Gianfranco, Proitsi, Petroula, Collinge, John, Sorbi, Sandro, Sanchez Garcia, Florentino, Fox, Nick C, Hardy, John, Deniz Naranjo, Maria Candida, Bosco, Paolo, Brayne, Carol, Galimberti, Daniela, Mancuso, Michelangelo, Matthews, Fiona, Moebus, Susanne, Mecocci, Patrizia, DEL ZOMPO, MARIA RITA, Maier, Wolfgang, Hampel, Harald, Pilotto, Alberto, Bullido, Maria, Panza, Francesco, Caffarra, Paolo, Nacmias, Benedetta, Gilbert, John R, Mayhaus, Manuel, Lannfelt, Lars, Hakonarson, Hakon, Pichler, Sabrina, Carrasquillo, Minerva M, Ingelsson, Martin, Beekly, Duane, Alvarez, Victoria, Zou, Fanggeng, Valladares, Otto, Younkin, Steven G, Coto, Eliecer, Hamilton Nelson, Kara L, Wei, Gu, Razquin, Cristina, Pastor, Pau, Mateo, Ignacio, Owen, Michael J, Faber, Kelley M, Jonsson, Palmi V, Combarros, Onofre, O'Donovan, Michael C, Cantwell, Laura B, Soininen, Hilkka, Blacker, Deborah, Mead, Simon, Mosley, Thomas H, Bennett, David A, Harris, Tamara B, Fratiglioni, Laura, Holmes, Clive, De Bruijn, Renee F. A. G, Passmore, Peter, Montine, Thomas J, Bettens, Karolien, Rotter, Jerome I, Brice, Alexis, Morgan, Kevin, Foroud, Tatiana M, Kukull, Walter A, Hannequin, Didier, Powell, John F, Nalls, Michael A, Ritchie, Karen, Lunetta, Kathryn L, Kauwe, John S. K, Boerwinkle, Eric, Riemenschneider, Matthias, Boada, Mercè, Hiltunen, Mikko, Martin, Eden R, Schmidt, Reinhold, Rujescu, Dan, Wang, Li San, Dartigues, Jean François, Mayeux, Richard, Tzourio, Christophe, Hofman, Albert, Nöthen, Markus M, Graff, Caroline, Jones, Lesley, Haines, Jonathan L, Holmans, Peter A, Lathrop, Mark, Pericak Vance, Margaret A, Launer, Lenore J, Farrer, Lindsay A, Van Duijn, Cornelia M, Van Broeckhoven, Christine, Moskvina, Valentina, Schellenberg, Gerard D, and Amouyel, Philippe

Subjects
Neurology, Neurology (clinical), Research Articles, Research Article
Abstract

Objective Increasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases. Methods Using genome‐wide association study (GWAS) data from METASTROKE + (15,916 IS cases and 68,826 controls) and the International Genomics of Alzheimer's Project (IGAP; 17,008 AD cases and 37,154 controls), we evaluated known associations with AD and IS. On the subset of data for which we could obtain compatible genotype‐level data (4,610 IS cases, 1,281 AD cases, and 14,320 controls), we estimated the genome‐wide genetic correlation (rG) between AD and IS, and the three subtypes (cardioembolic, small vessel, and large vessel), using genome‐wide single‐nucleotide polymorphism (SNP) data. We then performed a meta‐analysis and pathway analysis in the combined AD and small vessel stroke data sets to identify the SNPs and molecular pathways through which disease risk may be conferred. Results We found evidence of a shared genetic contribution between AD and small vessel stroke (rG [standard error] = 0.37 [0.17]; p = 0.011). Conversely, there was no evidence to support shared genetic factors in AD and IS overall or with the other stroke subtypes. Of the known GWAS associations with IS or AD, none reached significance for association with the other trait (or stroke subtypes). A meta‐analysis of AD IGAP and METASTROKE + small vessel stroke GWAS data highlighted a region (ATP5H/KCTD2/ICT1) associated with both diseases (p = 1.8 × 10−8). A pathway analysis identified four associated pathways involving cholesterol transport and immune response. Interpretation Our findings indicate shared genetic susceptibility to AD and small vessel stroke and highlight potential causal pathways and loci. Ann Neurol 2016;79:739–747

Published
2016

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