Search

Your search keyword '"Davidson, Andrew J."' showing total 203 results
Start Over Author "Davidson, Andrew J." Search Limiters Full Text
203 results on '"Davidson, Andrew J."'

3. Estimating pediatric general anesthesia exposure: Quantifying duration and risk

Author

Bartels, Devan Darby, McCann, Mary Ellen, Davidson, Andrew J, Polaner, David M, Whitlock, Elizabeth L, and Bateman, Brian T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Clinical Research, Patient Safety, Anesthesia, General, Child, Child, Preschool, Cohort Studies, Female, Humans, Infant, Male, Pediatrics, Retrospective Studies, Risk, Time Factors, adolescent, child, general anesthesia, infant, neonate, neurodevelopment, Paediatrics and Reproductive Medicine, Anesthesiology, Clinical sciences, Paediatrics
Abstract

INTRODUCTION:Understanding the duration of pediatric general anesthesia exposure in contemporary practice is important for identifying groups at risk for long general anesthesia exposures and designing trials examining associations between general anesthesia exposure and neurodevelopmental outcomes. METHODS:We performed a retrospective cohort analysis to estimate pediatric general anesthesia exposure duration during 2010-2015 using the National Anesthesia Clinical Outcomes Registry. RESULTS:A total of 1 548 021 pediatric general anesthetics were included. Median general anesthesia duration was 57 minutes (IQR: 28-86) with 90th percentile 145 minutes. Children aged 3 hours. High ASA physical status and care at a university hospital were associated with longer exposure times. CONCLUSION:While the vast majority (94%) of children undergoing general anesthesia are exposed for

Published
2018

6. The role of WASP family members in Dictyostelium discoideum cell migration

Author

Davidson, Andrew J.

Subjects
572, QH301 Biology, QH426 Genetics
Abstract

The WASP family of proteins are nucleation-promoting factors that dictate the temporal and spatial dynamics of Arp2/3 complex recruitment, and hence actin polymerisation. Consequently, members of the WASP family, such as SCAR/WAVE and WASP, drive processes such as pseudopod formation and clathrin-mediated endocytosis, respectively. However, the nature of functional specificity or overlap of WASP family members is controversial and also appears to be contextual. For example, some WASP family members appear capable of assuming each other’s roles in cells that are mutant for certain family members. How the activity of each WASP family member is normally limited to promoting the formation of a specific subset of actin-based structures and how they are able to escape these constraints in order to substitute for one another, remain unanswered questions. Furthermore, how the WASP family members collectively contribute to complex processes such as cell migration is yet to be addressed. To examine these concepts in an experimentally and genetically tractable system we have used the single celled amoeba Dictyostelium discoideum. The regulation of SCAR via its regulatory complex was investigated by dissecting the Abi subunit. Abi was found to be essential for complex stability but not for its recruitment to the cell cortex or its role in pseudopod formation. The roles of WASP A were examined by generating a wasA null strain. Our results contradicted previous findings suggesting that WASP A was essential for pseudopod formation and instead demonstrated that WASP A was required for clathrin-mediated endocytosis. Unexpectedly, WASP A – driven clathrin-mediated endocytosis was found to be necessary for efficient uropod retraction during cell migration and furrowing during cytokinesis. Finally, we created a double scrA/wasA mutant, and found that it was unable to generate pseudopodia. Therefore, we were able to confirm that SCAR is the predominant driver of pseudopod formation in wild-type Dictyostelium cells, and that only WASP A can assume its role in the scrA null. Surprisingly, the double mutant was also deficient in bleb formation, showing that these proteins are also necessary for this alternative, Arp2/3 complex-independent mode of motility. This implies that there exists interplay between the different types of actin-based protrusions and the molecular pathways that underlie their formation.

Published
2014

14. Anesthesia and Developing Brains: Unanswered Questions and Proposed Paths Forward

Author

Ing, Caleb, primary, Warner, David O., additional, Sun, Lena S., additional, Flick, Randall P., additional, Davidson, Andrew J., additional, Vutskits, Laszlo, additional, McCann, Mary Ellen, additional, O’Leary, James, additional, Bellinger, David C., additional, Rauh, Virginia, additional, Orser, Beverley A., additional, Suresh, Santhanam, additional, and Andropoulos, Dean B., additional

Published
2022
Full Text
View/download PDF

18. Authorship and Publication Matters: Credit and Credibility

Author

Kharasch, Evan D., primary, Avram, Michael J., additional, Bateman, Brian T., additional, Clark, J. David, additional, Culley, Deborah J., additional, Davidson, Andrew J., additional, Houle, Timothy T., additional, Jiang, Yandong, additional, Levy, Jerrold H., additional, London, Martin J., additional, Sleigh, Jamie W., additional, and Vutskits, Laszlo, additional

Published
2021
Full Text
View/download PDF

20. Peer Review Matters: Research Quality and the Public Trust

Author

Kharasch, Evan D., primary, Avram, Michael J., additional, Clark, J. David, additional, Davidson, Andrew J., additional, Houle, Timothy T., additional, Levy, Jerrold H., additional, London, Martin J., additional, Sessler, Daniel I., additional, and Vutskits, Laszlo, additional

Published
2020
Full Text
View/download PDF

21. Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo.

Author

Raymond, Michael H., Davidson, Andrew J., Yi Shen, Tudor, Daniel R., Lucas, Christopher D., Sho Morioka, Perry, Justin S. A., Krapivkina, Julia, Perrais, David, Schumacher, Linus J., Campbell, Robert E., Wood, Will, and Ravichandran, Kodi S.

Subjects
*MACROPHAGES, *DROSOPHILA, *MOLECULAR biology, *EMBRYOS, *EMBRYOLOGY
Abstract

The article discusses known and unexpected features of apoptosis and macrophage efferocytosis during Drosophila embryo development in vivo. A genetically encoded fluorescent reporter Caspase and pH Activated Reporter, Fluorescence ON, was developed to track emerging apoptotic cells and their efferocytic clearance by phagocytes. The macrophages displayed heterogeneity in engulfment behaviors, leading to some efferocytic macrophages carrying a high corpse burden.

Published
2022
Full Text
View/download PDF

22. Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis

Author

Davidson, Andrew J., Millard, Tom H., Evans, Iwan R., and Wood, Will

Subjects
Inflammation, Wound Healing, Macrophage, Chemotaxis, Macrophages, Microfilament Proteins, Short Report, Formins, Hemocyte, macromolecular substances, Ena, Animals, Genetically Modified, DNA-Binding Proteins, Actin Cytoskeleton, Multiprotein Complexes, Animals, Drosophila Proteins, Drosophila, Pseudopodia, Carrier Proteins, Actin, Migration, Protein Binding
Abstract

The actin cytoskeleton is the engine that powers the inflammatory chemotaxis of immune cells to sites of tissue damage or infection. Here, we combine genetics with live in vivo imaging to investigate how cytoskeletal rearrangements drive macrophage recruitment to wounds in Drosophila. We find that the actin-regulatory protein Ena is a master regulator of lamellipodial dynamics in migrating macrophages, where it remodels the cytoskeleton to form linear filaments that can then be bundled together by the cross-linker Fascin (also known as Singed in flies). In contrast, the formin Dia generates rare, probing filopods for specialised functions that are not required for migration. The role of Ena in lamellipodial bundling is so fundamental that its overexpression increases bundling even in the absence of Fascin by marshalling the remaining cross-linking proteins to compensate. This reorganisation of the lamellipod generates cytoskeletal struts that push against the membrane to drive leading edge advancement and boost cell speed. Thus, Ena-mediated remodelling extracts the most from the cytoskeleton to power robust macrophage chemotaxis during their inflammatory recruitment to wounds., Summary: Macrophages must migrate to a variety of stimuli, including inflammatory wounds. We identify the actin-regulatory protein Ena as a master remodeller of the cytoskeleton within migrating macrophages in vivo.

Published
2019
Full Text
View/download PDF

24. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

Author

Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, Williams, Robert, Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, and Williams, Robert

Abstract

Background In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have found no evidence for an association. We aimed to establish whether general anaesthesia in early infancy affects neurodevelopmental outcomes. Methods In this international, assessor-masked, equivalence, randomised, controlled trial conducted at 28 hospitals in Australia, Italy, the USA, the UK, Canada, the Netherlands, and New Zealand, we recruited infants of less than 60 weeks' postmenstrual age who were born at more than 26 weeks' gestation and were undergoing inguinal herniorrhaphy, without previous exposure to general anaesthesia or risk factors for neurological injury. Patients were randomly assigned (1:1) by use of a web-based randomisation service to receive either awake-regional anaesthetic or sevoflurane-based general anaesthetic. Anaesthetists were aware of group allocation, but individuals administering the neurodevelopmental assessments were not. Parents were informed of their infants group allocation upon request, but were told to mask this information from assessors. The primary outcome measure was full-scale intelligence quotient (FSIQ) on the Wechsler Preschool and Primary Scale of Intelligence, third edition (WPPSI-III), at 5 years of age. The primary analysis was done on a per-protocol basis, adjusted for gestational age at birth and country, with multiple imputation used to account for missing data. An intention-to-treat analysis was also done. A difference in means of 5 points was predefined as the clinical equivalence margin. This completed trial is registered with ANZCTR, number ACTRN12606000441516, and ClinicalTrials.gov, number NCT00756600. Findings Between F

Published
2019

25. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, Williams, Robert, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Mccann, Mary Ellen, De Graaff, Jurgen C, Dorris, Liam, Disma, Nicola, Withington, Davinia, Bell, Graham, Grobler, Anneke, Stargatt, Robyn, Hunt, Rodney W, Sheppard, Suzette J, Marmor, Jacki, Giribaldi, Gaia, Bellinger, David, Hartmann, Penelope L, Hardy, Pollyanna, Frawley, Geoff, Izzo, Francesca, Von Ungern-sternberg, Britta, Lynn, Anne, Wilton, Niall, Mueller, Martin, Polaner, David M, Absalom, Anthony R, Szmuk, Peter, Morton, Neil S, Berde, Charles, Soriano, Sulpicio, Davidson, Andrew J, Arnup, Sarah, Lee, Katherine, Hunt, Rod W, Ormond, Gillian D, Takagi, Michael J, Taylor, Kaitlyn, Malarbi, Stephanie, Doyle, Melissa, Ragg, Philip, Costi, David, Wilton, Niall C, Knottenbelt, Graham, Furue, Koto, Gagnon, Hélène, Mameli, Leila, Pini Prato, Alessio, Mattioli, Girolamo, Wolfler, Andrea, Bova, Stefania M, Krachmalnicoff, Arianna, Guuva, Claudia, Van Der Werff, Desiree Bm, Van Gool, Jose Tdg, Van Loon, Kim, Kalkman, Cor J, Van Baar, Anneloes L, Hoekstra, Frouckje M, Volkers, Martin, Oostra, Martine, Pownall, Jaycee, Waldman, Jack, Hind, Ruth, Symonds, Joseph D, Bagshaw, Oliver, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Haret, Denisa, Steiner, Jeffrey, Kravitz, Brian, Farrow-gillespie, Alan, Suresh, Santhanam, Hays, Stephen, Taenzer, Andreas, Maxwell, Lynne, and Williams, Robert

Published
2019

28. Unravelling the Actin Cytoskeleton:A New Competitive Edge?

Author

Davidson, Andrew J. and Wood, Will

Subjects
ENA/VASP PROTEINS, CAPPING PROTEIN, cytoskeleton, FISSION YEAST, IN-VITRO, Cell Biology, macromolecular substances, CELL-MIGRATION, WAVE-COMPLEX, ARP2/3 COMPLEX, PROFILIN, FILAMENT NUCLEATION, filopod, MACROPHAGE-MIGRATION, chemotaxis, lamellipod, actin, competition
Abstract

Dynamic rearrangements in the actin cytoskeleton underlie a wide range of cell behaviours, which in turn contribute to many aspects of human health including embryogenesis, cancer metastasis, wound healing, and inflammation. Precise control of the actin cytoskeleton requires the coordinated activity of a diverse set of different actin regulators. However, our current understanding of the actin cytoskeleton has focused on how individual actin regulatory pathways function in isolation from one another. Recently, competition has emerged as a means by which different actin assembly factors can influence each other's activity at the cellular level. Here such findings will be used to explore the possibility that competition within the actin cytoskeleton confers cellular plasticity and the ability to prioritise multiple conflicting stimuli.

Published
2016
Full Text
View/download PDF

29. Protocol for a double blind, randomised placebo-controlled trial using ondansetron to reduce vomiting in children receiving intranasal fentanyl and inhaled nitrous oxide for procedural sedation in the emergency department (the FON trial)

Author

Fauteux-Lamarre, Emmanuelle, primary, Babl, Franz E, additional, Davidson, Andrew J, additional, Legge, Donna, additional, Lee, Katherine J, additional, Palmer, Greta M, additional, and Hopper, Sandy M, additional

Published
2018
Full Text
View/download PDF

32. Predictors of Failure of Awake Regional Anesthesia for Neonatal Hernia Repair : Data from the General Anesthesia Compared to Spinal Anesthesia Study--Comparing Apnea and Neurodevelopmental Outcomes

Author

Frawley, Geoff, Bell, Graham, Disma, Nicola, Withington, Davinia E, de Graaff, Jurgen C, Morton, Neil S, McCann, Mary Ellen, Arnup, Sarah J, Bagshaw, Oliver, Wolfler, Andrea, Bellinger, David, Davidson, Andrew J, Absalom, Anthony, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
Male, Internationality, Apnea, Research Support, Non-U.S. Gov't, Infant, Newborn, Research Support, U.S. Gov't, P.H.S, Infant, Hernia, Inguinal, Anesthesia, General, Anesthesia, Spinal, Cohort Studies, Multicenter Study, Child Development, Treatment Outcome, Research Support, N.I.H., Extramural, Anesthesia, Conduction, Predictive Value of Tests, Randomized Controlled Trial, Journal Article, Humans, Female, Single-Blind Method, Comparative Study, Prospective Studies, Treatment Failure
Abstract

BACKGROUND: Awake regional anesthesia (RA) is a viable alternative to general anesthesia (GA) for infants undergoing lower abdominal surgery. Benefits include lower incidence of postoperative apnea and avoidance of anesthetic agents that may increase neuroapoptosis and worsen neurocognitive outcomes. The General Anesthesia compared to Spinal anesthesia study compares neurodevelopmental outcomes after awake RA or GA in otherwise healthy infants. The aim of the study is to describe success and failure rates of RA and report factors associated with failure. METHODS: This was a nested cohort study within a prospective, randomized, controlled, observer-blind, equivalence trial. Seven hundred twenty-two infants 60 weeks or less postmenstrual age scheduled for herniorrhaphy under anesthesia were randomly assigned to receive RA (spinal, caudal epidural, or combined spinal caudal anesthetic) or GA with sevoflurane. The data of 339 infants, where spinal or combined spinal caudal anesthetic was attempted, were analyzed. Possible predictors of failure were assessed including patient factors, technique, experience of site and anesthetist, and type of local anesthetic. RESULTS: RA was sufficient for the completion of surgery in 83.2% of patients. Spinal anesthesia was successful in 86.9% of cases and combined spinal caudal anesthetic in 76.1%. Thirty-four patients required conversion to GA, and an additional 23 patients (6.8%) required brief sedation. Bloody tap on the first attempt at lumbar puncture was the only risk factor significantly associated with block failure (odds ratio = 2.46). CONCLUSIONS: The failure rate of spinal anesthesia was low. Variability in application of combined spinal caudal anesthetic limited attempts to compare the success of this technique to spinal alone.

Published
2015

33. Apnea after Awake Regional and General Anesthesia in Infants: The General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes, a Randomized Controlled Trial

Author

Davidson, Andrew J, Morton, Neil S, Arnup, Sarah J, de Graaff, Jurgen C, Disma, Nicola, Withington, Davinia E, Frawley, Geoff, Hunt, Rodney W, Hardy, Pollyanna, Khotcholava, Magda, von Ungern Sternberg, Britta S, Wilton, Niall, Tuo, Pietro, Salvo, Ida, Ormond, Gillian, Stargatt, Robyn, Locatelli, Bruno Guido, McCann, Mary Ellen, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
RISK, COMPLICATIONS, CAFFEINE, CHILDREN, FORMER PRETERM INFANTS, POSTOPERATIVE APNEA, INGUINAL HERNIORRHAPHY
Abstract

BACKGROUND: Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia. METHODS: Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apnea up to 12 h postoperatively. Apnea assessment was unblinded. RESULTS: Three hundred sixty-three patients were assigned to RA and 359 to GA. Overall, the incidence of apnea (0 to 12 h) was similar between arms (3% in RA and 4% in GA arms; odds ratio [OR], 0.63; 95% CI, 0.31 to 1.30, P = 0.2133); however, the incidence of early apnea (0 to 30 min) was lower in the RA arm (1 vs. 3%; OR, 0.20; 95% CI, 0.05 to 0.91; P = 0.0367). The incidence of late apnea (30 min to 12 h) was 2% in both RA and GA arms (OR, 1.17; 95% CI, 0.41 to 3.33; P = 0.7688). The strongest predictor of apnea was prematurity (OR, 21.87; 95% CI, 4.38 to 109.24), and 96% of infants with apnea were premature. CONCLUSIONS: RA in infants undergoing inguinal herniorrhaphy reduces apnea in the early postoperative period. Cardiorespiratory monitoring should be used for all ex-premature infants.

Published
2015

34. Differences in Blood Pressure in Infants after General Anesthesia Compared to Awake Regional Anesthesia (GAS Study - A Prospective Randomized Trial)

Author

McCANN, M.E., Withington, Davinia E., Arnup, Sarah J., Davidson, Andrew J., DISMA, N., FRAWLEY, G., Morton, Neil S., BELL, G., Hunt, Rodney W., Bellinger, David C, Polaner, D. M., Leo-Macias, Alejandra, Absalom, Anthony R., Von Ungern-Sternberg, Britta S., Izzo, Francesca, Szmuk, Peter, Young, Vanessa, Soriano, S. G., De Graaff, J. C., McCANN, M.E., Withington, Davinia E., Arnup, Sarah J., Davidson, Andrew J., DISMA, N., FRAWLEY, G., Morton, Neil S., BELL, G., Hunt, Rodney W., Bellinger, David C, Polaner, D. M., Leo-Macias, Alejandra, Absalom, Anthony R., Von Ungern-Sternberg, Britta S., Izzo, Francesca, Szmuk, Peter, Young, Vanessa, Soriano, S. G., and De Graaff, J. C.

Published
2017

35. Differences in Blood Pressure in Infants after General Anesthesia Compared to Awake Regional Anesthesia (GAS Study - A Prospective Randomized Trial)

Author

UMC Utrecht, Brain, Medische staf Anesthesiologie, McCANN, M.E., Withington, Davinia E., Arnup, Sarah J., Davidson, Andrew J., DISMA, N., FRAWLEY, G., Morton, Neil S., BELL, G., Hunt, Rodney W., Bellinger, David C, Polaner, D. M., Leo-Macias, Alejandra, Absalom, Anthony R., Von Ungern-Sternberg, Britta S., Izzo, Francesca, Szmuk, Peter, Young, Vanessa, Soriano, S. G., De Graaff, J. C., UMC Utrecht, Brain, Medische staf Anesthesiologie, McCANN, M.E., Withington, Davinia E., Arnup, Sarah J., Davidson, Andrew J., DISMA, N., FRAWLEY, G., Morton, Neil S., BELL, G., Hunt, Rodney W., Bellinger, David C, Polaner, D. M., Leo-Macias, Alejandra, Absalom, Anthony R., Von Ungern-Sternberg, Britta S., Izzo, Francesca, Szmuk, Peter, Young, Vanessa, Soriano, S. G., and De Graaff, J. C.

Published
2017

37. The GAS trial - Authors' reply

Author

Davidson, Andrew J., Disma, Nicola, De Graaff, Jurgen C., Withington, Davinia E., McCann, Mary Ellen, Davidson, Andrew J., Disma, Nicola, De Graaff, Jurgen C., Withington, Davinia E., and McCann, Mary Ellen

Published
2016

38. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS) : an international multicentre, randomised controlled trial

Author

Davidson, Andrew J, Disma, Nicola, de Graaff, Jurgen C, Withington, Davinia E, Dorris, Liam, Bell, Graham, Stargatt, Robyn, Bellinger, David C, Schuster, Tibor, Arnup, Sarah J, Hardy, Pollyanna, Hunt, Rodney W, Takagi, Michael J, Giribaldi, Gaia, Hartmann, Penelope L, Salvo, Ida, Morton, Neil S, von Ungern Sternberg, Britta S, Locatelli, Bruno Guido, Wilton, Niall, Lynn, Anne, Thomas, Joss J, Polaner, David, Bagshaw, Oliver, Szmuk, Peter, Absalom, Anthony R, Frawley, Geoff, Berde, Charles, Ormond, Gillian D, Marmor, Jacki, McCann, Mary Ellen, GAS consortium, Davidson, Andrew J, Disma, Nicola, de Graaff, Jurgen C, Withington, Davinia E, Dorris, Liam, Bell, Graham, Stargatt, Robyn, Bellinger, David C, Schuster, Tibor, Arnup, Sarah J, Hardy, Pollyanna, Hunt, Rodney W, Takagi, Michael J, Giribaldi, Gaia, Hartmann, Penelope L, Salvo, Ida, Morton, Neil S, von Ungern Sternberg, Britta S, Locatelli, Bruno Guido, Wilton, Niall, Lynn, Anne, Thomas, Joss J, Polaner, David, Bagshaw, Oliver, Szmuk, Peter, Absalom, Anthony R, Frawley, Geoff, Berde, Charles, Ormond, Gillian D, Marmor, Jacki, McCann, Mary Ellen, and GAS consortium

Published
2016

39. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

Author

Development and Treatment of Psychosocial Problems, Davidson, Andrew J, Disma, Nicola, De Graaff, Jurgen C, Withington, Davinia E, Dorris, Liam, Bell, Graham, Stargatt, Robyn, Bellinger, David C, Schuster, Tibor, Arnup, Sarah J, Hardy, Pollyanna, Hunt, Rodney W, Takagi, Michael J, Giribaldi, Gaia, Hartmann, Penelope L, Salvo, Ida, Morton, Neil S, Von Ungern Sternberg, Britta S, Locatelli, Bruno Guido, Wilton, Niall, Lynn, Anne, Thomas, Joss J, Polaner, David, Bagshaw, Oliver, Szmuk, Peter, Absalom, Anthony R, Frawley, Geoff, Berde, Charles, Ormond, Gillian D, Marmor, Jacki, Mccann, Mary Ellen, Development and Treatment of Psychosocial Problems, Davidson, Andrew J, Disma, Nicola, De Graaff, Jurgen C, Withington, Davinia E, Dorris, Liam, Bell, Graham, Stargatt, Robyn, Bellinger, David C, Schuster, Tibor, Arnup, Sarah J, Hardy, Pollyanna, Hunt, Rodney W, Takagi, Michael J, Giribaldi, Gaia, Hartmann, Penelope L, Salvo, Ida, Morton, Neil S, Von Ungern Sternberg, Britta S, Locatelli, Bruno Guido, Wilton, Niall, Lynn, Anne, Thomas, Joss J, Polaner, David, Bagshaw, Oliver, Szmuk, Peter, Absalom, Anthony R, Frawley, Geoff, Berde, Charles, Ormond, Gillian D, Marmor, Jacki, and Mccann, Mary Ellen

Published
2016

40. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

Author

Medische staf Anesthesiologie, Brain, Davidson, Andrew J, Disma, Nicola, de Graaff, Jurgen C, Withington, Davinia E, Dorris, Liam, Bell, Graham, Stargatt, Robyn, Bellinger, David C, Schuster, Tibor, Arnup, Sarah J, Hardy, Pollyanna, Hunt, Rodney W, Takagi, Michael J, Giribaldi, Gaia, Hartmann, Penelope L, Salvo, Ida, Morton, Neil S, von Ungern Sternberg, Britta S, Locatelli, Bruno Guido, Wilton, Niall, Lynn, Anne, Thomas, Joss J, Polaner, David, Bagshaw, Oliver, Szmuk, Peter, Absalom, Anthony R, Frawley, Geoff, Berde, Charles, Ormond, Gillian D, Marmor, Jacki, McCann, Mary Ellen, GAS consortium, Medische staf Anesthesiologie, Brain, Davidson, Andrew J, Disma, Nicola, de Graaff, Jurgen C, Withington, Davinia E, Dorris, Liam, Bell, Graham, Stargatt, Robyn, Bellinger, David C, Schuster, Tibor, Arnup, Sarah J, Hardy, Pollyanna, Hunt, Rodney W, Takagi, Michael J, Giribaldi, Gaia, Hartmann, Penelope L, Salvo, Ida, Morton, Neil S, von Ungern Sternberg, Britta S, Locatelli, Bruno Guido, Wilton, Niall, Lynn, Anne, Thomas, Joss J, Polaner, David, Bagshaw, Oliver, Szmuk, Peter, Absalom, Anthony R, Frawley, Geoff, Berde, Charles, Ormond, Gillian D, Marmor, Jacki, McCann, Mary Ellen, and GAS consortium

Published
2016

42. The GAS trial - Authors' reply

Author

Medische staf Anesthesiologie, Brain, Davidson, Andrew J., Disma, Nicola, De Graaff, Jurgen C., Withington, Davinia E., McCann, Mary Ellen, Medische staf Anesthesiologie, Brain, Davidson, Andrew J., Disma, Nicola, De Graaff, Jurgen C., Withington, Davinia E., and McCann, Mary Ellen

Published
2016

43. WASP family proteins and formins compete in pseudopod- and bleb-based migration.

Author

Davidson, Andrew J., Amato, Clelia, Thomason, Peter A., and Insall, Robert H.

Subjects
*WISKOTT-Aldrich syndrome protein, *INTERNAL migration, *FILOPODIA, *PSYCHOLOGY
Abstract

Actin pseudopods induced by SCAR/WAVE drive normal migration and chemotaxis in eukaryotic cells. Cells can also migrate using blebs, in which the edge is driven forward by hydrostatic pressure instead of actin. In Dictyostelium discoideum, loss of SCAR is compensated by WASP moving to the leading edge to generate morphologically normal pseudopods. Here we use an inducible double knockout to show that cells lacking both SCAR and WASP are unable to grow, make pseudopods or, unexpectedly, migrate using blebs. Remarkably, amounts and dynamics of actin polymerization are normal. Pseudopods are replaced in double SCAR/WASP mutants by aberrant filopods, induced by the formin dDia2. Further disruption of the gene for dDia2 restores cells' ability to initiate blebs and thus migrate, though pseudopods are still lost. Triple knockout cells still contain near-normal F-actin levels. This work shows that SCAR, WASP, and dDia2 compete for actin. Loss of SCAR and WASP causes excessive dDia2 activity, maintaining F-actin levels but blocking pseudopod and bleb formation and migration. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

44. SCAR/WAVE

Author

Davidson, Andrew J. and Insall, Robert H.

Abstract

The SCAR/WAVE complex drives the actin polymerisation that underlies protrusion of the front of the cell and thus drives migration. However, it is not understood how the activity of SCAR/WAVE is regulated to generate the infinite range of cellular shape changes observed during cell motility. What are the relative roles of the subunits of the SCAR/WAVE complex? What signaling molecules do they interact with? And how does the complex integrate all this information in order to control the temporal and spatial polymerisation of actin during protrusion formation? Unfortunately, the interdependence of SCAR complex members has made genetic dissection hard. In our recent paper,1 we describe stabilization of the Dictyostelium SCAR complex by a small fragment of Abi. Here we summarize the main findings and discuss how this approach can help reveal the inner workings of this impenetrable complex.

Published
2013

45. Erratum : Anesthesia and the developing brain: A way forward for clinical research (Pediatric Anesthesia (2015) 25 (447-452)

Author

Davidson, Andrew J., Becke, Karin, De Graaff, Jurgen, Giribaldi, Gaia, Habre, Walid, Hansen, Tom, Hunt, Rodney W., Ing, Caleb, Loepke, Andreas, McCann, Mary Ellen, Ormond, Gillian D., Prato, Alessio Pini, Salvo, Ida, Sun, Lena, Vutskits, Laszlo, Walker, Suellen, Disma, Nicola, Davidson, Andrew J., Becke, Karin, De Graaff, Jurgen, Giribaldi, Gaia, Habre, Walid, Hansen, Tom, Hunt, Rodney W., Ing, Caleb, Loepke, Andreas, McCann, Mary Ellen, Ormond, Gillian D., Prato, Alessio Pini, Salvo, Ida, Sun, Lena, Vutskits, Laszlo, Walker, Suellen, and Disma, Nicola

Published
2015

46. Apnea after Awake Regional and General Anesthesia in Infants : The General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes, a Randomized Controlled Trial

Author

Davidson, Andrew J., Morton, Neil S., Arnup, Sarah J., De Graaff, Jurgen C., Disma, Nicola, Withington, Davinia E., Frawley, Geoff, Hunt, Rodney W., Hardy, Pollyanna, Khotcholava, Magda, Von Ungern Sternberg, Britta S., Wilton, Niall, Tuo, Pietro, Salvo, Ida, Ormond, Gillian, Stargatt, Robyn, Locatelli, Bruno Guido, McCann, Mary Ellen, Lee, Katherine, Sheppard, Suzette, Hartmann, Penelope, Ragg, Philip, Backstrom, Marie, Costi, David, Von Ungern-Sternberg, Britta S., Knottenbelt, Graham, Montobbio, Giovanni, Mameli, Leila, Giribaldi, Gaia, Prato, Alessio Pini, Mattioli, Girolamo, Wolfler, Andrea, Izzo, Francesca, Sonzogni, Valter, Van Gool, Jose T D G, Numan, Sandra C., Kalkman, Cor J., Hagenaars, J. H M, Absalom, Anthony R., Hoekstra, Frouckje M., Volkers, Martin J., Furue, Koto, Gaudreault, Josee, Berde, Charles, Soriano, Sulpicio, Young, Vanessa, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph P., Bellinger, David, Marmor, Jacki, Lynn, Anne, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Meuller, Martin, Haret, Denisa, Szmuk, Peter, Steiner, Jeffery, Kravitz, Brian, Suresh, Santhanam, Hays, Stephen R., Taenzer, Andreas H., Maxwell, Lynne G., Williams, Robert K., Bell, Graham T., Dorris, Liam, Adey, Claire, Bagshaw, Oliver, Chisakuta, Anthony, Eissa, Ayman, Stoddart, Peter, Davis, Annette, Myles, Paul, Wolf, Andy, McIntosh, Neil, Carlin, John, Leslie, Kate, De Lima, Jonathan, Hammer, Greg, Field, David, Gebski, Val, Tibboel, Dick, Davidson, Andrew J., Morton, Neil S., Arnup, Sarah J., De Graaff, Jurgen C., Disma, Nicola, Withington, Davinia E., Frawley, Geoff, Hunt, Rodney W., Hardy, Pollyanna, Khotcholava, Magda, Von Ungern Sternberg, Britta S., Wilton, Niall, Tuo, Pietro, Salvo, Ida, Ormond, Gillian, Stargatt, Robyn, Locatelli, Bruno Guido, McCann, Mary Ellen, Lee, Katherine, Sheppard, Suzette, Hartmann, Penelope, Ragg, Philip, Backstrom, Marie, Costi, David, Von Ungern-Sternberg, Britta S., Knottenbelt, Graham, Montobbio, Giovanni, Mameli, Leila, Giribaldi, Gaia, Prato, Alessio Pini, Mattioli, Girolamo, Wolfler, Andrea, Izzo, Francesca, Sonzogni, Valter, Van Gool, Jose T D G, Numan, Sandra C., Kalkman, Cor J., Hagenaars, J. H M, Absalom, Anthony R., Hoekstra, Frouckje M., Volkers, Martin J., Furue, Koto, Gaudreault, Josee, Berde, Charles, Soriano, Sulpicio, Young, Vanessa, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph P., Bellinger, David, Marmor, Jacki, Lynn, Anne, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Meuller, Martin, Haret, Denisa, Szmuk, Peter, Steiner, Jeffery, Kravitz, Brian, Suresh, Santhanam, Hays, Stephen R., Taenzer, Andreas H., Maxwell, Lynne G., Williams, Robert K., Bell, Graham T., Dorris, Liam, Adey, Claire, Bagshaw, Oliver, Chisakuta, Anthony, Eissa, Ayman, Stoddart, Peter, Davis, Annette, Myles, Paul, Wolf, Andy, McIntosh, Neil, Carlin, John, Leslie, Kate, De Lima, Jonathan, Hammer, Greg, Field, David, Gebski, Val, and Tibboel, Dick

Published
2015

47. Anesthesia and the developing brain : A way forward for clinical research

Author

Davidson, Andrew J., Becke, Karin, De Graaff, Jurgen, Giribaldi, Gaia, Habre, Walid, Hansen, Tom, Hunt, Rodney W., Ing, Caleb, Loepke, Andreas, McCann, Mary Ellen, Ormond, Gillian D., Pini Prato, Alessio, Salvo, Ida, Sun, Lena, Vutskits, Laszlo, Walker, Suellen, Disma, Nicola, Davidson, Andrew J., Becke, Karin, De Graaff, Jurgen, Giribaldi, Gaia, Habre, Walid, Hansen, Tom, Hunt, Rodney W., Ing, Caleb, Loepke, Andreas, McCann, Mary Ellen, Ormond, Gillian D., Pini Prato, Alessio, Salvo, Ida, Sun, Lena, Vutskits, Laszlo, Walker, Suellen, and Disma, Nicola

Published
2015

48. Predictors of Failure of Awake Regional Anesthesia for Neonatal Hernia Repair: Data from the General Anesthesia Compared to Spinal Anesthesia Study--Comparing Apnea and Neurodevelopmental Outcomes

Author

Medische staf Anesthesiologie, Frawley, Geoff, Bell, Graham, Disma, Nicola, Withington, Davinia E, de Graaff, Jurgen C, Morton, Neil S, McCann, Mary Ellen, Arnup, Sarah J, Bagshaw, Oliver, Wolfler, Andrea, Bellinger, David, Davidson, Andrew J, General Anesthesia compared to Spinal anesthesia (GAS) Consortium, Medische staf Anesthesiologie, Frawley, Geoff, Bell, Graham, Disma, Nicola, Withington, Davinia E, de Graaff, Jurgen C, Morton, Neil S, McCann, Mary Ellen, Arnup, Sarah J, Bagshaw, Oliver, Wolfler, Andrea, Bellinger, David, Davidson, Andrew J, and General Anesthesia compared to Spinal anesthesia (GAS) Consortium

Published
2015

49. Erratum: Anesthesia and the developing brain: A way forward for clinical research (Pediatric Anesthesia (2015) 25 (447-452)

Author

Medische staf Anesthesiologie, Brain, Davidson, Andrew J., Becke, Karin, De Graaff, Jurgen, Giribaldi, Gaia, Habre, Walid, Hansen, Tom, Hunt, Rodney W., Ing, Caleb, Loepke, Andreas, McCann, Mary Ellen, Ormond, Gillian D., Prato, Alessio Pini, Salvo, Ida, Sun, Lena, Vutskits, Laszlo, Walker, Suellen, Disma, Nicola, Medische staf Anesthesiologie, Brain, Davidson, Andrew J., Becke, Karin, De Graaff, Jurgen, Giribaldi, Gaia, Habre, Walid, Hansen, Tom, Hunt, Rodney W., Ing, Caleb, Loepke, Andreas, McCann, Mary Ellen, Ormond, Gillian D., Prato, Alessio Pini, Salvo, Ida, Sun, Lena, Vutskits, Laszlo, Walker, Suellen, and Disma, Nicola

Published
2015

50. Apnea after Awake Regional and General Anesthesia in Infants: The General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes, a Randomized Controlled Trial

Author

Medische staf Anesthesiologie, Circulatory Health, Brain, Davidson, Andrew J., Morton, Neil S., Arnup, Sarah J., De Graaff, Jurgen C., Disma, Nicola, Withington, Davinia E., Frawley, Geoff, Hunt, Rodney W., Hardy, Pollyanna, Khotcholava, Magda, Von Ungern Sternberg, Britta S., Wilton, Niall, Tuo, Pietro, Salvo, Ida, Ormond, Gillian, Stargatt, Robyn, Locatelli, Bruno Guido, McCann, Mary Ellen, Lee, Katherine, Sheppard, Suzette, Hartmann, Penelope, Ragg, Philip, Backstrom, Marie, Costi, David, Von Ungern-Sternberg, Britta S., Knottenbelt, Graham, Montobbio, Giovanni, Mameli, Leila, Giribaldi, Gaia, Prato, Alessio Pini, Mattioli, Girolamo, Wolfler, Andrea, Izzo, Francesca, Sonzogni, Valter, Van Gool, Jose T D G, Numan, Sandra C., Kalkman, Cor J., Hagenaars, J. H M, Absalom, Anthony R., Hoekstra, Frouckje M., Volkers, Martin J., Furue, Koto, Gaudreault, Josee, Berde, Charles, Soriano, Sulpicio, Young, Vanessa, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph P., Bellinger, David, Marmor, Jacki, Lynn, Anne, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Meuller, Martin, Haret, Denisa, Szmuk, Peter, Steiner, Jeffery, Kravitz, Brian, Suresh, Santhanam, Hays, Stephen R., Taenzer, Andreas H., Maxwell, Lynne G., Williams, Robert K., Bell, Graham T., Dorris, Liam, Adey, Claire, Bagshaw, Oliver, Chisakuta, Anthony, Eissa, Ayman, Stoddart, Peter, Davis, Annette, Myles, Paul, Wolf, Andy, McIntosh, Neil, Carlin, John, Leslie, Kate, De Lima, Jonathan, Hammer, Greg, Field, David, Gebski, Val, Tibboel, Dick, Medische staf Anesthesiologie, Circulatory Health, Brain, Davidson, Andrew J., Morton, Neil S., Arnup, Sarah J., De Graaff, Jurgen C., Disma, Nicola, Withington, Davinia E., Frawley, Geoff, Hunt, Rodney W., Hardy, Pollyanna, Khotcholava, Magda, Von Ungern Sternberg, Britta S., Wilton, Niall, Tuo, Pietro, Salvo, Ida, Ormond, Gillian, Stargatt, Robyn, Locatelli, Bruno Guido, McCann, Mary Ellen, Lee, Katherine, Sheppard, Suzette, Hartmann, Penelope, Ragg, Philip, Backstrom, Marie, Costi, David, Von Ungern-Sternberg, Britta S., Knottenbelt, Graham, Montobbio, Giovanni, Mameli, Leila, Giribaldi, Gaia, Prato, Alessio Pini, Mattioli, Girolamo, Wolfler, Andrea, Izzo, Francesca, Sonzogni, Valter, Van Gool, Jose T D G, Numan, Sandra C., Kalkman, Cor J., Hagenaars, J. H M, Absalom, Anthony R., Hoekstra, Frouckje M., Volkers, Martin J., Furue, Koto, Gaudreault, Josee, Berde, Charles, Soriano, Sulpicio, Young, Vanessa, Sethna, Navil, Kovatsis, Pete, Cravero, Joseph P., Bellinger, David, Marmor, Jacki, Lynn, Anne, Ivanova, Iskra, Hunyady, Agnes, Verma, Shilpa, Polaner, David, Thomas, Joss, Meuller, Martin, Haret, Denisa, Szmuk, Peter, Steiner, Jeffery, Kravitz, Brian, Suresh, Santhanam, Hays, Stephen R., Taenzer, Andreas H., Maxwell, Lynne G., Williams, Robert K., Bell, Graham T., Dorris, Liam, Adey, Claire, Bagshaw, Oliver, Chisakuta, Anthony, Eissa, Ayman, Stoddart, Peter, Davis, Annette, Myles, Paul, Wolf, Andy, McIntosh, Neil, Carlin, John, Leslie, Kate, De Lima, Jonathan, Hammer, Greg, Field, David, Gebski, Val, and Tibboel, Dick

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results