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1. Assessing the communication gap between AI models and healthcare professionals: explainability, utility and trust in AI-driven clinical decision-making

Author

Wysocki, Oskar, Davies, Jessica Katharine, Vigo, Markel, Armstrong, Anne Caroline, Landers, Dónal, Lee, Rebecca, and Freitas, André

Subjects
Computer Science - Artificial Intelligence, Computer Science - Human-Computer Interaction, Computer Science - Machine Learning
Abstract

This paper contributes with a pragmatic evaluation framework for explainable Machine Learning (ML) models for clinical decision support. The study revealed a more nuanced role for ML explanation models, when these are pragmatically embedded in the clinical context. Despite the general positive attitude of healthcare professionals (HCPs) towards explanations as a safety and trust mechanism, for a significant set of participants there were negative effects associated with confirmation bias, accentuating model over-reliance and increased effort to interact with the model. Also, contradicting one of its main intended functions, standard explanatory models showed limited ability to support a critical understanding of the limitations of the model. However, we found new significant positive effects which repositions the role of explanations within a clinical context: these include reduction of automation bias, addressing ambiguous clinical cases (cases where HCPs were not certain about their decision) and support of less experienced HCPs in the acquisition of new domain knowledge., Comment: supplementary information in the main pdf

Published
2022
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3. PhET Simulations in Undergraduate Physics: Constructivist Learning Theory in Practice

Author

Saudelli, Mary Gene, Kleiv, Robin, Davies, Jessica, Jungmark, Martin, and Mueller, Rebecca

Abstract

Simulation educational technologies provide a convenient way to augment classroom learning in higher education. The University of Colorado Boulder has created many Physics Education Technology (PhET) computer simulations relevant to concepts in Sciences and Mathematics. There is a notable gap in the literature of simulation-based technologies, learning theories, and Physics pedagogy in higher education. This action research study addresses that gap by exploring the role of the intentional inclusion of PhETs in the teaching practice of an undergraduate Physics class in a Canadian university. The professor of PHYS 105 taught a class of 80 students (primarily non-Physics majors) and integrated PhETs throughout his lesson plans during the semester to see if they supported students' learning of the Physics concepts. Findings indicate that PhETs have value as a "more capable peer" in Vygotsky's (1978) zone of proximal development. Findings indicate that PhETs are a valuable bridge between classroom learning and the laboratory learning experiences in a Physics higher education course.

Published
2021

4. Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS

Author

Pallett, Laura J., Swadling, Leo, Diniz, Mariana, Maini, Alexander A., Schwabenland, Marius, Gasull, Adrià Dalmau, Davies, Jessica, Kucykowicz, Stephanie, Skelton, Jessica K., Thomas, Niclas, Schmidt, Nathalie M., Amin, Oliver E., Gill, Upkar S., Stegmann, Kerstin A., Burton, Alice R., Stephenson, Emily, Reynolds, Gary, Whelan, Matt, Sanchez, Jenifer, de Maeyer, Roel, Thakker, Clare, Suveizdyte, Kornelija, Uddin, Imran, Ortega-Prieto, Ana M., Grant, Charlotte, Froghi, Farid, Fusai, Giuseppe, Lens, Sabela, Pérez-del-Pulgar, Sofia, Al-Akkad, Walid, Mazza, Giuseppe, Noursadeghi, Mahdad, Akbar, Arne, Kennedy, Patrick T. F., Davidson, Brian R., Prinz, Marco, Chain, Benjamin M., Haniffa, Muzlifah, Gilroy, Derek W., Dorner, Marcus, Bengsch, Bertram, Schurich, Anna, and Maini, Mala K.

Published
2023
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5. The use of registry data to extrapolate overall survival results from randomised controlled trials

Author

Martina, Reynaldo, Abrams, Keith, Bujkiewicz, Sylwia, Jenkins, David, Dequen, Pascale, Lees, Michael, Corvino, Frank A., and Davies, Jessica

Subjects
Statistics - Applications, Statistics - Methodology
Abstract

Background: Pre-marketing authorisation estimates of survival are generally restricted to those observed directly in randomised controlled trials (RCTs). However, for regulatory and Health Technology Assessment (HTA) decision-making a longer time horizon is often required than is studied in RCTs. Therefore, extrapolation is required to estimate long-term treatment effect. Registry data can provide evidence to support extrapolation of treatment effects from RCTs, which are considered the main sources of evidence of effect for new drug applications. A number of methods are available to extrapolate survival data, such as Exponential, Weibull, Gompertz, log-logistic or log-normal parametric models. The different methods have varying functional forms and can result in different survival estimates. Methods: The aim of this paper was to use registry data to supplement the relatively short term RCT data to obtain long term estimates of effect. No formal hypotheses were tested. We explore the above parametric regression models as well as a nonparametric regression model based on local linear (parametric) regression. We also explore a Bayesian model constrained to the long term estimate of survival reported in literature, a Bayesian power prior approach on the variability observed from published literature, and a Bayesian Model Averaging (BMA) approach. The methods were applied to extrapolate overall survival of a RCT in metastatic melanoma. Results: The results showed that the BMA approach was able to fit the RCT data well, with the lowest variability of the area under the curve up to 72 months with or without the SEER Medicare registry. Conclusion: the BMA approach is a viable approach to extrapolate overall survival in the absence of long term data., Comment: 21 Pages, 7 named figures, 3 tables

Published
2019

12. Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Author

Kaur, Gurman, Porter, Caroline B. M., Ashenberg, Orr, Lee, Jack, Riesenfeld, Samantha J., Hofree, Matan, Aggelakopoulou, Maria, Subramanian, Ayshwarya, Kuttikkatte, Subita Balaram, Attfield, Kathrine E., Desel, Christiane A. E., Davies, Jessica L., Evans, Hayley G., Avraham-Davidi, Inbal, Nguyen, Lan T., Dionne, Danielle A., Neumann, Anna E., Jensen, Lise Torp, Barber, Thomas R., Soilleux, Elizabeth, Carrington, Mary, McVean, Gil, Rozenblatt-Rosen, Orit, Regev, Aviv, and Fugger, Lars

Published
2022
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14. Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Author

Swadling, Leo, Diniz, Mariana O., Schmidt, Nathalie M., Amin, Oliver E., Chandran, Aneesh, Shaw, Emily, Pade, Corinna, Gibbons, Joseph M., Le Bert, Nina, Tan, Anthony T., Jeffery-Smith, Anna, Tan, Cedric C. S., Tham, Christine Y. L., Kucykowicz, Stephanie, Aidoo-Micah, Gloryanne, Rosenheim, Joshua, Davies, Jessica, Johnson, Marina, Jensen, Melanie P., Joy, George, McCoy, Laura E., Valdes, Ana M., Chain, Benjamin M., Goldblatt, David, Altmann, Daniel M., Boyton, Rosemary J., Manisty, Charlotte, Treibel, Thomas A., Moon, James C., van Dorp, Lucy, Balloux, Francois, McKnight, Áine, Noursadeghi, Mahdad, Bertoletti, Antonio, and Maini, Mala K.

Published
2022
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15. Exploring the role of L-selectin shedding in regulating neutrophil polarity and chemotaxis

Author

Davies, Jessica Ellen and Ivetic, Aleksandar

Subjects
616.1
Abstract

Inflammation is a biological response to injury – a fundamental part of which involves the influx of leukocytes to the affected area. Circulating neutrophils are typically the first responders to an inflammatory insult. Orchestrated interactions between neutrophils and the underlying endothelium and occurs in a process termed the “multi-step leukocyte adhesion cascade”. L-selectin, a cell adhesion molecule, expressed on all circulating neutrophils, and facilitates the initial tethering and rolling events. Previously, L-selectin on CD14-positive (“inflammatory”) monocytes was shown to undergo ectodomain “shedding”, exclusively during transendothelial migration (TEM) and not before. The consequence of this was to establish monocyte polarity within the subendothelial space. The primary aim of this project was to determine if L-selectin shedding during TEM was exclusive to monocytes or extended to neutrophils. Perfusion of primary human neutrophils over activated endothelial monolayers revealed that L-selectin shedding was also activated specifically during TEM. Ectopic expression of L-selectin tagged to green fluorescent protein (GFP) in HL-60 cells (a neutrophil-like cell line that does not express endogenous L-selectin) significantly increased their invasive potential across activated endothelial cells under flow. Blocking L-selectin shedding (either pharmacologically in primary neutrophils or genetically in HL60 cells) promoted cell elongation in fully transmigrated cells, which significantly impacted cell polarity and directional persistence in 2D and 3D collagen scaffolds. Additionally, manufacturing bespoke microfluidic flow chamber devices revealed that blocking L-selectin shedding impacted the neutrophil chemotaxis towards classic “end-stage chemoattractants”, such as fMLP. Taken together, L-selectin shedding ensures that fully transmigrated neutrophils can establish front-back polarity so that they can home optimally to their inflamed targets. As fMLP is secreted during sterile injury, the potential therapeutic targeting of L-selectin shedding in the setting of myocardial infarction is discussed.

Published
2017

16. A Symbolic SAT-based Algorithm for Almost-sure Reachability with Small Strategies in POMDPs

Author

Chatterjee, Krishnendu, Chmelik, Martin, and Davies, Jessica

Subjects
Computer Science - Artificial Intelligence
Abstract

POMDPs are standard models for probabilistic planning problems, where an agent interacts with an uncertain environment. We study the problem of almost-sure reachability, where given a set of target states, the question is to decide whether there is a policy to ensure that the target set is reached with probability 1 (almost-surely). While in general the problem is EXPTIME-complete, in many practical cases policies with a small amount of memory suffice. Moreover, the existing solution to the problem is explicit, which first requires to construct explicitly an exponential reduction to a belief-support MDP. In this work, we first study the existence of observation-stationary strategies, which is NP-complete, and then small-memory strategies. We present a symbolic algorithm by an efficient encoding to SAT and using a SAT solver for the problem. We report experimental results demonstrating the scalability of our symbolic (SAT-based) approach., Comment: Full version of "A Symbolic SAT-based Algorithm for Almost-sure Reachability with Small Strategies in POMDPs" AAAI 2016

Published
2015

18. Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Author

Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., and Jones, Joanne L.

Published
2021
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22. Eliminating the Weakest Link: Making Manipulation Intractable?

Author

Davies, Jessica, Narodytska, Nina, and Walsh, Toby

Subjects
Computer Science - Artificial Intelligence, Computer Science - Computational Complexity, Computer Science - Computer Science and Game Theory, I.2.11
Abstract

Successive elimination of candidates is often a route to making manipulation intractable to compute. We prove that eliminating candidates does not necessarily increase the computational complexity of manipulation. However, for many voting rules used in practice, the computational complexity increases. For example, it is already known that it is NP-hard to compute how a single voter can manipulate the result of single transferable voting (the elimination version of plurality voting). We show here that it is NP-hard to compute how a single voter can manipulate the result of the elimination version of veto voting, of the closely related Coombs' rule, and of the elimination versions of a general class of scoring rules., Comment: To appear in Proceedings of Twenty-Sixth Conference on Artificial Intelligence (AAAI-12)

Published
2012

23. Complexity of and Algorithms for Borda Manipulation

Author

Davies, Jessica, Katsirelos, George, Narodytska, Nina, and Walsh, Toby

Subjects
Computer Science - Artificial Intelligence
Abstract

We prove that it is NP-hard for a coalition of two manipulators to compute how to manipulate the Borda voting rule. This resolves one of the last open problems in the computational complexity of manipulating common voting rules. Because of this NP-hardness, we treat computing a manipulation as an approximation problem where we try to minimize the number of manipulators. Based on ideas from bin packing and multiprocessor scheduling, we propose two new approximation methods to compute manipulations of the Borda rule. Experiments show that these methods significantly outperform the previous best known %existing approximation method. We are able to find optimal manipulations in almost all the randomly generated elections tested. Our results suggest that, whilst computing a manipulation of the Borda rule by a coalition is NP-hard, computational complexity may provide only a weak barrier against manipulation in practice.

Published
2011

24. An Empirical Study of Borda Manipulation

Author

Davies, Jessica, Katsirelos, George, Narodystka, Nina, and Walsh, Toby

Subjects
Computer Science - Artificial Intelligence, I.2.4
Abstract

We study the problem of coalitional manipulation in elections using the unweighted Borda rule. We provide empirical evidence of the manipulability of Borda elections in the form of two new greedy manipulation algorithms based on intuitions from the bin-packing and multiprocessor scheduling domains. Although we have not been able to show that these algorithms beat existing methods in the worst-case, our empirical evaluation shows that they significantly outperform the existing method and are able to find optimal manipulations in the vast majority of the randomly generated elections that we tested. These empirical results provide further evidence that the Borda rule provides little defense against coalitional manipulation., Comment: To appear in Proceedings of the Third International Workshop on Computational Social Choice

Published
2010

25. SARS-CoV-2-specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies

Author

Jeffery-Smith, Anna, Burton, Alice R., Lens, Sabela, Rees-Spear, Chloe, Davies, Jessica, Patel, Monika, Gopal, Robin, Muir, Luke, Aiano, Felicity, Doores, Katie J., Chow, J. Yimmy, Ladhani, Shamez N., Zambon, Maria, McCoy, Laura E., and Maini, Mala K.

Subjects
Aged -- Health aspects -- Physiological aspects, Immunologic memory -- Research, Immunological research, Viral antibodies -- Health aspects -- Physiological aspects, B cells -- Health aspects -- Physiological aspects, Antibodies -- Health aspects -- Physiological aspects, Health care industry
Abstract

Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median age of 87 years and 56 years, respectively), who had survived COVID-19 outbreaks with only mild or asymptomatic infection. The cohort was selected because of its high proportion of individuals who had lost neutralizing antibodies (nAbs), thus allowing us to specifically investigate the reserve immunity from SARS-CoV-2-specific MBCs in this setting. Classswitched spike and receptor-binding domain (RBD) tetramer-binding MBCs persisted 5 months after mild or asymptomatic SARS-CoV-2 infection, irrespective of age. The majority of spike- and RBD-specific MBCs had a classical phenotype, but we found that activated MBCs, indicating possible ongoing antigenic stimulation or inflammation, were expanded in the elderly group. Spike- and RBD-specific MBCs remained detectable in the majority of individuals who had lost nAbs, although at lower frequencies and with a reduced IgG/IgA isotype ratio. Functional spike-, S1 subunit of the spike protein- (S1-), and RBDspecific recall was also detectable by enzyme-linked immune absorbent spot (ELISPOT) assay in some individuals who had lost nAbs, but was significantly impaired in the elderly. Our findings demonstrate that a reserve of SARS-CoV-2- specific MBCs persists beyond the loss of nAbs but highlight the need for careful monitoring of functional defects in spike- and RBD- specific B cell immunity in the elderly., Introduction The human coronavirus SARS-CoV-2 has had a particularly devastating impact on the elderly, who are at much greater risk of morbidity and mortality (1, 2). Understanding the nature of [...]

Published
2022
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27. Modelling, control and monitoring of high redundancy actuation

Author

Davies, Jessica

Subjects
621, Control, Fault tolerant systems, Fault detection and diagnosis, Active fault-tolerant control, Multi-agent systems, Actuation systems
Abstract

The High Redundancy Actuator (HRA) project investigates a novel approach to fault tolerant actuation, which uses a high number of small actuation elements, assembled in series and parallel in order to form a single intrinsically fault tolerant actuator. Element faults affect the maximum capability of the overall actuator, but through control techniques, the required performance can be maintained. This allows higher levels of reliability to be attained in exchange for less over-dimensioning in comparison to conventional redundancy techniques. In addition, the combination of both serial and parallel elements provides intrinsic accommodation of both lock-up and loose faults. Research to date has concentrated on HRAs based on electromechanical technology, of relatively low order, controlled through passive Fault Tolerant Control (FTC) methods. The objective of this thesis is to expand upon this work. HRA configurations of higher order, formed from electromagnetic actuators are considered. An element model for a moving coil actuator is derived from first principles and verified experimentally. This element model is then used to form high-order, non-linear HRA models for simulation, and reduced-order representations for control design. A simple, passive FTC law is designed for the HRA configurations, the results of which are compared to a decentralised, active FTC approach applied through a framework based upon multi-agent concepts. The results indicate that limited fault tolerance can be achieved through simple passive control, however, performance degradation occurs, and requirements are not met under theoretically tolerable fault levels. Active FTC offers substantial performance improvements, meeting the requirements of the system under the vast majority of theoretically tolerable fault scenarios. However, these improvements are made at the cost of increased system complexity and a reliance on fault detection. Fault Detection (FD) and health monitoring of the HRA is explored. A simple rule-based FD method, for use within the active FTC, is described and simulated. An interacting multiple model FD method is also examined, which is more suitable for health monitoring in a centralised control scheme. Both of these methods provide the required level of fault information for their respective purposes. However, they achieve this through the introduction of complexity. The rule-based method increases system complexity, requiring high levels of instrumentation, and conversely the interacting multiple model approach involves complexity of design and computation. Finally, the development of a software demonstrator is described. Experimental rigs at the current project phase are restricted to relatively low numbers of elements for practical reasons such as cost, space and technological limitations. Hence, a software demonstrator has been developed in Matlab/Simulink which provides a visual representation of HRAs with larger numbers of elements, and varied configuration for further demonstration of this concept.

Published
2010

28. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Author

Global Health Research Unit on Global Surgery, National Institute for Health and Care Research, Adisa, Adewale, Bahrami-Hessari, Michael, Bhangu, Aneel, George, Christina, Ghosh, Dhruv, Glasbey, James, Haque, Parvez, Ingabire, J C Allen, Kamarajah, Sivesh Kathir, Kudrna, Laura, Ledda, Virginia, Li, Elizabeth, Lillywhite, Robert, Mittal, Rohin, Nepogodiev, Dmitri, Ntirenganya, Faustin, Picciochi, Maria, Simões, Joana Filipa Ferreira, Booth, L, Elliot, R, Kennerton, A S, Pettigrove, K L, Pinney, L, Richard, H, Tottman, R, Wheatstone, P, Wolfenden, John W D, Smith, A, Sayed, A Emad, Goswami, Aakansha Giri, Malik, Aamer, Mclean, Aaron Lawson, Hassan, Abbas, Nazimi, Abd Jabar, Aladna, Abdallah, Abdelgawad, Abdalrahman, Saed, Abdel, Abdelmageed, Abdelfatah, Ghannam, Abdelilah, Mahmoud, Abdelrahman, Alvi, Abdul, Ismail, Abdulaziz, Adesunkanmi, Abdulhafiz, Ebrahim, Abdulla, Al-Mallah, Abdullah, Alqallaf, Abdullah, Durrani, Abdullah, Gabr, Abdullah, Kirfi, Abdullahi Musa, Altaf, Abdulmalik, Almutairi, Abdulmjeed, Sabbagh, Abdulrahman J, Ajiya, Abdulrazak, Haddud, Abdurrahman, Alnsour, Abed Alfattah Mahmoud, Singh, Abhinav, Mittal, Abhishek, Semple, Abigail, Adeniran, Abiodun, Negussie, Abraham, Oladimeji, Abraham, Muhammad, Abubakar Bala, Yassin, Abubaker, Gungor, Abuzer, Tarsitano, Achille, Soibiharry, Adaiah, Dyas, Adam, Frankel, Adam, Peckham-Cooper, Adam, Truss, Adam, Issaka, Adamu, Ads, Adel Mohamed, Aderogba, Adeleke Akeem, Adeyeye, Ademola, Ademuyiwa, Adesoji, Sleem, Adham, Papa, Adrian, Cordova, Adriana, Appiah-Kubi, Adu, Meead, Adullah, Nacion, Aeris Jane D, Michael, Afieharo, Forneris, Agustin Albani, Duro, Agustin, Gonzalez, Agustin Rodriguez, Altouny, Ahmad, Ghazal, Ahmad, Khalifa, Ahmad, Ozair, Ahmad, Quzli, Ahmad, Haddad, Ahmad, Othman, Ahmad Faidzal, Yahaya, Ahmad Shuib, Elsherbiny, Ahmed, Nazer, Ahmed, Tarek, Ahmed, Abu-Zaid, Ahmed, Al-Nusairi, Ahmed, Azab, Ahmed, Elagili, Ahmed, Elkazaz, Ahmed, Kedwany, Ahmed, Nuhu, Ahmed Mohammed, Sakr, Ahmed, Shehta, Ahmed, Shirazi, Ahmed, Mohamed, Ahmed Mohamed Ibrahim, Sherif, Ahmed Elshawadfy, Awad, Ahmed K, Abbas, Ahmed M, Abdelrahman, Ahmed Saber, Ammar, Ahmed Siddique, Azzam, Ahmed Y, Ciftci, Ahmet Burak, Dural, Ahmet Cem, Sanli, Ahmet Necati, Rahy-Martín, Aida Cristina, Tantri, Aida Rosita, Khan, Aimal, Al-Touny, Aiman, Tariq, Aiman, Gmati, Aimen, Costas-Chavarri, Ainhoa, Auerkari, Aino, Landaluce-Olavarria, Aitor, Puri, Ajay, Radhakrishnan, Ajay, Ubom, Akaninyene Eseme, Pradhan, Akhilesh, Turna, Akif, Adepiti, Akinfolarin, Kuriyama, Akira, Kassam, Al-Faraaz, Hassouneh, Ala, El-Hussuna, Alaa, Habeebullah, Alaa, Ads, Alaa Mohamed, Mousli, Alaa, Biloslavo, Alan, Hoang, Alan, Kirk, Alan, Santini, Alasdair, Melero, Alba Vazquez, Calvache, Albaro José Nieto, Baduell, Albert, Chan, Albert, Abrate, Alberto, Balduzzi, Alberto, Sánchez, Alberto Cabañero, Navarrete-Peón, Alberto, Porcu, Alberto, Brolese, Alberto, Barranquero, Alberto G, Saibene, Alberto Maria, Adam, Albushra Altayeb, Vagge, Aldo, Maquilón, Alejandra Jara, Leon-Andrino, Alejandro, Sekulić, Aleksandar, Trifunovski, Aleksandar, Mako, Aleksandro, Bedada, Alemayehu Ginbo, Broglia, Alessandro, Coppola, Alessandro, Giani, Alessandro, Grandi, Alessandro, Iacomino, Alessandro, Moro, Alessandro, D’amico, Alessia, Malagnino, Alessia, Tang, Alethea, Doyle, Alex, Alfieri, Alex, Haynes, Alex, Wilkins, Alex, Baldwin, Alexander, Heriot, Alexander, Laird, Alexander, Lazarides, Alexander, O'connor, Alexander, Trulson, Alexander, Rokohl, Alexander Christopher, Caziuc, Alexandra, Triantafyllou, Alexandra, Anesi, Alexandre, Nikova, Alexandrina, Andrianakis, Alexandros, Charalabopoulos, Alexandros, Tsolakidis, Alexandros, Chirca, Alexandru, Arnaud, Alexis P, Narvaez-Rojas, Alexis Rafael, Kavalakat, Alfie, Spina, Alfio, Recordare, Alfonso, Annicchiarico, Alfredo, Conti, Alfredo, Mohammed, Alhassan Datti, Kocataş, Ali, Almhimid, Ali, Arnaout, Ali, Fahmy, Ali, Mangi, Ali, Modabber, Ali, Ulas, Ali Bilal, Mohamedahmed, Ali Yasen Y, Frontali, Alice, Moynihan, Alice, Yunus, Alif, Ahmad, Aline, Kent, Alistair J, Khamees, Almu'atasim, Ugwu, Aloy Okechukwu, Turan, Alparslan, Mohammed, Alsnosy Abdullah Khalefa, Navarro-Barrios, Alvaro, Yebes, Alvaro, De Sousa, Álvaro Francisco Lopes, Moreno, Amabelle, Sethi, Aman, Dawson, Amanda Caroline, Othman, Amani Alsayd Abdulsalam, Kaur, Amanjot, Wolde, Amanuel, Antonelli, Amedeo, Scifo, Amedeo, Alhamad, Ameen, Davis, Amelia, Alderazi, Amer, Harky, Amer, Mohammed-Durosinlorun, Amina, Seguya, Amina, Okhakhu, Amina, Chamakhi, Amine, Sebai, Amine, Souadka, Amine, Asla, Amir, Agrawal, Amit, Persad, Amit, Gupta, Amit, Elgazar, Amr, Kulkarni, Amruta, Coates, Amy, Bellés, Ana Ciscar, Hadzibegovic, Ana Danic, Jotic, Ana, Kowark, Ana, Martins, Ana, Pineda, Ana Mejía, Peral, Ana, Gollarte, Ana Sánchez, Senent-Boza, Ana, Camarena, Ana Isabel Avellaneda, Castaño-Leon, Ana M, Bravo, Ana Maria Minaya, Moro, Ana María Gimeno, Musina, Ana-Maria, Tapia-Herrero, Ana-María, Kothari, Anai, Gupta, Anand, Raja, Anand, Aljaiuossi, Anas, Taha, Anas, Majbar, Anass Mohammed, Prodromidou, Anastasia, Kanatas, Anastasios, Gupte, Anaya, Zakaria, Andee Dzulkarnaen, Balla, Andrea, Barberis, Andrea, Bondurri, Andrea, Bottari, Andrea, Costantino, Andrea, Figus, Andrea, Lauretta, Andrea, Mingoli, Andrea, Romanzi, Andrea, Sagnotta, Andrea, Scacchi, Andrea, Picchetto, Andrea, Valadez, Andrea Estefania Cueto, Luzzi, Andrea-Pierre, Älgå, Andreas, Fontalis, Andreas, Hecker, Andreas, Demetriades, Andreas K, Serban, Andreea-Madalina, Văcărașu, Andrei Bogdan, Cokan, Andrej, Isaza-Restrepo, Andres, Beamish, Andrew, Schache, Andrew, Stevenson, Andrew, Yiu, Andrew, Cockbain, Andrew J, Litvin, Andrey, Abad-Motos, Ane, Becerra, Angel, Ramos, Ángel Cilleruelo, Chiaradia, Angela, Dell, Angela, Romano, Angela, Pascale, Angelo, Marra, Angelo Alessandro, Dimas, Angelos, Kolias, Angelos, Cerovac, Anis, Koneru, Anish, Tidjane, Anisse, Agbeko, Anita Eseenam, Bajaj, Ankur, Gosain, Ankush, Allan, Anna, Carreras-Castañer, Anna, D'amore, Anna, Dare, Anna, Maffioli, Anna, Palepa, Anna, Paspala, Anna, Konney, Anna, Gatta, Anna Nunzia Della, Ezanno, Anne-Cecile, Yiallourou, Anneza, Kinnair, Anthony, Rayner, Anthony, Scafa, Anthony Kevin, Bowan, Antoinette Bediako, Veglia, Antonella, Russo, Antonino, Maniaci, Antonino, Castaldi, Antonio, Gil-Moreno, Antonio, Maffuz-Aziz, Antonio, Meola, Antonio, Nenna, Antonio, Ferrer, Antonio Perez, Bonilla, Antonio Ramos, Ramos-De La Medina, Antonio, Infante, Antonio Rodriguez, Santoro, Antonio, Laganà, Antonio Simone, Bateman, Antony, Michael, Antony Louis Rex, Abozid, Anwaar, Seidu, Anwar Sadat, Lowery, Aoife, Tantraworasin, Apichat, Rasheed, Aqsa, Picciariello, Arcangelo, Isik, Arda, Saif, Areeba, Anjum, Arfa, Ioannidis, Argyrios, Abeldaño, Ariel, Hussain, Arif, Nathan, Arjun, Bedzhanyan, Arkady, Perfecto, Arkaitz, De Virgilio, Armando, Galvan, Armando, Sablotzki, Armin, Böttcher, Arne, Pellacani, Arrigo, Gatti, Arthur, Ibrahimli, Arturan, Menon, Arun, Sahni, Arun, Mwenda, Aruyaru Stanley, Choudhry, Asad, Jayawardane, Asanka, Gupta, Ashish, Ramasamy, Ashok, Mitul, Ashrarur Rahman, Bawa, Ashvind, Nugur, Ashwani, Rammohan, Ashwin, Sachdeva, Ashwin, Mehraj, Asif, Yildirim, Asif, Alqaseer, Asma, Radwan, Asmaa, Sallam, Asser, Syllaios, Athanasios, Tampakis, Athanasios, Alwael, Athari, Samara, Athina, Eroglu, Atilla, Rahman, Atiqur, Ulkucu, Attila, Zaránd, Attila, Dulskas, Audrius, Tawiah, Augustine, Zani, Augusto, Vas, Aurelia, Lukosiute-Urboniene, Ausra, Adamu, Auwal, Aujayeb, Avinash, Malik, Awais Amjad, İplikçi, Ayberk, Mahmud, Ayesha, Cil, Aylin Pelin, Makanjuola, Ayomide, Akwaisah, Ayoub, Galandarova, Aysuna, Saracoglu, Ayten, Regan, Azel, Barlas, Aziz Mutlu, Alhassan, Baba Alhaji Bin, Mostafa, Badr, Hamida, Baha Ben, Torun, Bahar Canbay, Abdullah, Bahiyah, Balagobi, Balasingam, Banky, Balazs, Singh, Baljit, Alegbeleye, Bamidele, Yigit, Banu, Hajjaj, Baraa Nabil, Burgos-Blasco, Barbara, Seeliger, Barbara, Alayande, Barnabas, 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S, Katorkin, S, Valladares, S, Contreras, S, Meriç, S, Zenger, S, Safi, S, Leventoğlu, S, Elsalhawy, S, Shaikh, S, Sheik, S, Islam, S, Shamim, S, Waqar, S, Farid, S, Seraj, S, Sundarraju, S, Karandikar, S, Sambhwani, S, Chopra, S, Chowdhury, S, Laura, S, Ahmed, S, Wason, S, Tan, S, Fraser, S, Williams, S, Ghozy, S, Abdelmawgoud, S, Shehata, S, Sharma, S, Al-Touny, S, Ramzanali, S, Nah, S, Jansen, S, Rajan, S, Dindyal, S, Amin, S, Shoukrie, S, Karar, S, Patkar, S, Abdulsalam, S, Lin, S, Hegde, S, Fiorelli, S, Quaresima, S, Redondo, S, Palmisano, S, Ruggiero, S, Balogun, S, Cais, S, Cole, S, Federer, S, Le Roux, S, Ippoliti, S, Meneghini, S, Viola, S, Manfredelli, S, Novello, S, Gananadha, S, Mesli, S, Tani, S, Malik, S, Anastasiadou, S, Boligo, S, Esposito, S, Valanci, S, Xenaki, S, Pejkova, S, Trungu, S, Basu, S, Alkhatib, S, Pérez-Bertólez, S, Flores, S, Donoghue, S, Lunca, S, Orsoo, S, Potamianos, S, Devarakonda, S, Suresh, S, Croghan, S, Turi, S, Capella, S, Lucchini, S, Magnone, S, Salizzoni, S, Scabini, S, Scaringi, S, Cioffi, S, Seyfried, S, Degener, S, Potten, S, Taha-Mehlitz, S, Ali, S, Angamuthu, S, Mcaleer, S, Knight, S, White, S, Mantziari, S, Kykalos, S, Goh, S, Ibrahim, S, Elzwai, S, Bansal, S, Tripathy, S, Amrayev, S, Anwar, S, Banerjee, S, Thakar, S, Saeed, S, Venkatappa, S, Das, S, Techapongsatorn, S, Dube, S, Lee, S, González-Suárez, S, Henriques, S, Konjevoda, S, Gisbertz, S, Bravo, S, Mannan, S, Bukhari, S, Zafar, S, Batista, S, Chin, S, Arif, T, Lawal, T, Aktokmakyan, T, Osborn, T, Szakmany, T, Sztipits, T, Triantafyllou, T, Valadez, T, Singh, T, Khaliq, T, Patel, T, Fadalla, T, Jichi, T, Sammour, T, Al-Shaiji, T, Naggs, T, Barišić, T, Nikolouzakis, T, Bisgin, T, Perra, T, Uprak, T, Dagklis, T, Liakakos, T, Sidiropoulos, T, Adjeso, T, Dölker, T, Oung, T, Aherne, T, Diehl, T, Pinkney, T, Raymond, T, Rhomberg, T, Schmitz-Rixen, T, Madhuri, T, Lohmann, T, Yeoh, T, Zaimis, T, Bright, T, Vilz, T, Glowka, T, Board, T, Hardcastle, T, Cohnert, T, Mahečić, T, William, T, Klatte, T, Abbott, T, Watcyn-Jones, T, Mendes, T, Kulis, T, Sečan, T, Campagnaro, T, Frisoni, T, Simoncini, T, Violante, T, Safranovs, T, Risteski, T, Pang, T, Akinyemi, T, Yotsov, T, Laeke, T, Kochiyama, T, Sholadoye, T, Alekberli, T, Ezomike, U, Giustizieri, U, Grossi, U, Köksoy, Ü, Bork, U, Kisser, U, Ronellenfitsch, U, Saeed, U, Bracale, U, Jayarajah, U, Rauf, U, Bumbasirevic, U, Ferrer, U, Ahmed, U, Bello, U, Jogiat, U, Sadia, U, Galandarov, V, Narayanan, V, Calu, V, Bianchi, V, Ciniero, V, Tonini, V, Silvestri, V, Vijay, V, Dewan, V, Lohsiriwat, V, Thuduvage, V, Mousafeiris, V, Dragisic, V, Sasireka, V, Santric, V, Kusuma, V, Kolli, V, Alonso, V, De Simone, V, Picotti, V, Martínez, V, Panduro-Correa, V, Kakotkin, V, Angulo, V, Turrado-Rodriguez, V, Krishnamoorthy, V, Ban, V, Shah, V, Maiola, V, Giordano, V, La Vaccara, V, Lizzi, V, Papagni, V, Schiavone, V, Satchithanantham, V, Garcia-Virto, V, Jimenez, V, Kumar, V, Shelat, V, Bhat, V, Sodhai, V, Graziadei, V, Kutuzov, V, Stoyanov, V, Oktseloglou, V, Flis, V, Elhassan, W, Yang, W, Soon, W, Tashkandi, W, Al-Khyatt, W, Mabood, W, Bijou, W, Wijenayake, W, D, W, Krawczyk, W, Atkins, W, Bolton, W, White, W, Ceelen, W, Vagena, X, Gozal, Y, Baba, Y, Subramani, Y, Jansen, Y, Mittal, Y, Kara, Y, Zwain, Y, Noureldin, Y, Alawneh, Y, Aydin, Y, Lam, Y, Tang, Y, Lim, Y, Dean, Y, Tanas, Y, Su, Y, Fujimoto, Y, Altinel, Y, Frolova, Y, Oshodi, Y, Fadel, Z, Zahid, Z, Elahi, Z, Djama, Z, Zaheen, Z, Jawad, Z, Demetrashvili, Z, Gebremeskel, Z, Gudisa, Z, Alyami, Z, Garoufalia, Z, Li, Z, Zimak, Z, Radin, Z, and Balogh, Z

Subjects
general surgery, acute care surgery, Settore MED/18 - CHIRURGIA GENERALE, climate change, trauma, Settore MED/40 - Ginecologia E Ostetricia, environmental impact, surgery, Settore MED/31 - Otorinolaringoiatria, None, Medicine and Health Sciences, Surgery, operating theatre, environment
Abstract

Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.

Published
2023

30. Paving the way towards future‐proofing our crops

Author

Baekelandt, Alexandra, primary, Saltenis, Vandasue L. R., additional, Nacry, Philippe, additional, Malyska, Aleksandra, additional, Cornelissen, Marc, additional, Nanda, Amrit Kaur, additional, Nair, Abhishek, additional, Rogowsky, Peter, additional, Pauwels, Laurens, additional, Muller, Bertrand, additional, Collén, Jonas, additional, Blomme, Jonas, additional, Pribil, Mathias, additional, Scharff, Lars B., additional, Davies, Jessica, additional, Wilhelm, Ralf, additional, Rolland, Norbert, additional, Harbinson, Jeremy, additional, Boerjan, Wout, additional, Murchie, Erik H., additional, Burgess, Alexandra J., additional, Cohan, Jean‐Pierre, additional, Debaeke, Philippe, additional, Thomine, Sébastien, additional, Inzé, Dirk, additional, Lankhorst, René Klein, additional, and Parry, Martin A. J., additional

Published
2023
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31. Crop improvements for future‐proofing European food systems: A focus‐group‐driven analysis of agricultural production stakeholder priorities and viewpoints

Author

Stetkiewicz, Stacia, primary, Menary, Jonathan, additional, Nair, Abhishek, additional, Rufino, Mariana C., additional, Fischer, Arnout R.H., additional, Cornelissen, Marc, additional, Duchesne, Remi, additional, Guichaoua, Adrien, additional, Jorasch, Petra, additional, Lemarié, Stephane, additional, Nanda, Amrit K., additional, Wilhelm, Ralf, additional, and Davies, Jessica A.C., additional

Published
2022
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32. A Transient Printed Soil Decomposition Sensor Based on a Biopolymer Composite Conductor

Author

Atreya, Madhur, primary, Desousa, Stacie, additional, Kauzya, John‐Baptist, additional, Williams, Evan, additional, Hayes, Austin, additional, Dikshit, Karan, additional, Nielson, Jenna, additional, Palmgren, Abigail, additional, Khorchidian, Sara, additional, Liu, Shangshi, additional, Gopalakrishnan, Anupam, additional, Bihar, Eloise, additional, Bruns, Carson J., additional, Bardgett, Richard, additional, Quinton, John N., additional, Davies, Jessica, additional, Neff, Jason C., additional, and Whiting, Gregory L., additional

Published
2022
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35. Food System Resilience: Concepts, Issues, and Challenges

Author

Zurek, Monika, primary, Ingram, John, additional, Sanderson Bellamy, Angelina, additional, Goold, Conor, additional, Lyon, Christopher, additional, Alexander, Peter, additional, Barnes, Andrew, additional, Bebber, Daniel P., additional, Breeze, Tom D., additional, Bruce, Ann, additional, Collins, Lisa M., additional, Davies, Jessica, additional, Doherty, Bob, additional, Ensor, Jonathan, additional, Franco, Sofia C., additional, Gatto, Andrea, additional, Hess, Tim, additional, Lamprinopoulou, Chrysa, additional, Liu, Lingxuan, additional, Merkle, Magnus, additional, Norton, Lisa, additional, Oliver, Tom, additional, Ollerton, Jeff, additional, Potts, Simon, additional, Reed, Mark S., additional, Sutcliffe, Chloe, additional, and Withers, Paul J.A., additional

Published
2022
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36. Correction: L-selectin regulates human neutrophil transendothelial migration

Author

Rahman, Izajur, primary, Sánchez, Aida Collado, additional, Davies, Jessica, additional, Rzeniewicz, Karolina, additional, Abukscem, Sarah, additional, Joachim, Justin, additional, Hoskins Green, Hannah L., additional, Killock, David, additional, Sanz, Maria Jesus, additional, Charras, Guillaume, additional, Parsons, Maddy, additional, and Ivetic, Aleksandar, additional

Published
2022
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37. European consumer and societal stakeholders' response to crop improvements and new plant breeding techniques

Author

Nair, Abhishek, primary, Fischer, Arnout R. H., additional, Moscatelli, Silvana, additional, Socaciu, Carmen, additional, Kohl, Christian, additional, Stetkiewicz, Stacia S., additional, Menary, Jonathan, additional, Baekelandt, Alexandra, additional, Nanda, Amrit K., additional, Jorasch, Petra, additional, Davies, Jessica A. C., additional, and Wilhelm, Ralf, additional

Published
2022
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42. Isolation of human intrahepatic leukocytes for phenotypic and functional characterization by flow cytometry

Author

Kucykowicz, Stephanie, primary, Amin, Oliver E., additional, Burton, Alice R., additional, Swadling, Leo, additional, Schmidt, Nathalie M., additional, Zakeri, Nekisa, additional, Davies, Jessica, additional, Aidoo-Micah, Gloryanne, additional, Stegmann, Kerstin A., additional, Easom, Nicholas J., additional, Jeffery-Smith, Anna, additional, Maini, Mala K., additional, and Pallett, Laura J., additional

Published
2022
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46. A Transient Printed Soil Decomposition Sensor Based on a Biopolymer Composite Conductor.

Author

Atreya, Madhur, Desousa, Stacie, Kauzya, John‐Baptist, Williams, Evan, Hayes, Austin, Dikshit, Karan, Nielson, Jenna, Palmgren, Abigail, Khorchidian, Sara, Liu, Shangshi, Gopalakrishnan, Anupam, Bihar, Eloise, Bruns, Carson J., Bardgett, Richard, Quinton, John N., Davies, Jessica, Neff, Jason C., and Whiting, Gregory L.

Subjects
BIOPOLYMERS, SOILS, ENVIRONMENTAL degradation, FARM supplies, DETECTORS
Abstract

Soil health is one of the key factors in determining the sustainability of global agricultural systems and the stability of natural ecosystems. Microbial decomposition activity plays an important role in soil health; and gaining spatiotemporal insights into this attribute is critical for understanding soil function as well as for managing soils to ensure agricultural supply, stem biodiversity loss, and mitigate climate change. Here, a novel in situ electronic soil decomposition sensor that relies on the degradation of a printed conductive composite trace utilizing the biopolymer poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) as a binder is presented. This material responds selectively to microbially active environments with a continuously varying resistive signal that can be readily instrumented with low‐cost electronics to enable wide spatial distribution. In soil, a correlation between sensor response and intensity of microbial decomposition activity is observed and quantified by comparison with respiration rates over 14 days, showing that devices respond predictably to both static conditions and perturbations in general decomposition activity. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS.

Author

Pallett, Laura J., Swadling, Leo, Diniz, Mariana, Maini, Alexander A., Schwabenland, Marius, Gasull, Adrià Dalmau, Davies, Jessica, Kucykowicz, Stephanie, Skelton, Jessica K., Thomas, Niclas, Schmidt, Nathalie M., Amin, Oliver E., Gill, Upkar S., Stegmann, Kerstin A., Burton, Alice R., Stephenson, Emily, Reynolds, Gary, Whelan, Matt, Sanchez, Jenifer, and de Maeyer, Roel

Abstract

The liver is bathed in bacterial products, including lipopolysaccharide transported from the intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent pathogens and tumours1–4. The cellular basis mediating this tolerance, yet allowing a switch to immunity or immunopathology, needs to be better understood for successful immunotherapy of liver diseases. Here we show that a variable proportion of CD8+ T cells compartmentalized in the human liver co-stain for CD14 and other prototypic myeloid membrane proteins and are enriched in close proximity to CD14high myeloid cells in hepatic zone 2. CD14+CD8+ T cells preferentially accumulate within the donor pool in liver allografts, among hepatic virus-specific and tumour-infiltrating responses, and in cirrhotic ascites. CD14+CD8+ T cells exhibit increased turnover, activation and constitutive immunomodulatory features with high homeostatic IL-10 and IL-2 production ex vivo, and enhanced antiviral/anti-tumour effector function after TCR engagement. This CD14+CD8+ T cell profile can be recapitulated by the acquisition of membrane proteins—including the lipopolysaccharide receptor complex—from mononuclear phagocytes, resulting in augmented tumour killing by TCR-redirected T cells in vitro. CD14+CD8+ T cells express integrins and chemokine receptors that favour interactions with the local stroma, which can promote their induction through CXCL12. Lipopolysaccharide can also increase the frequency of CD14+CD8+ T cells in vitro and in vivo, and skew their function towards the production of chemotactic and regenerative cytokines. Thus, bacterial products in the gut–liver axis and tissue stromal factors can tune liver immunity by driving myeloid instruction of CD8+ T cells with immunomodulatory ability.Bacterial products in the gut–liver axis and tissue stromal factors can tune liver immunity by driving myeloid instruction of CD8+ T cells with immunomodulatory ability. [ABSTRACT FROM AUTHOR]

Published
2023
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48. CropBooster‐P: Towards a roadmap for plant research to future‐proof crops in Europe.

Author

Baekelandt, Alexandra, Saltenis, Vandasue L. R., Pribil, Mathias, Nacry, Philippe, Harbinson, Jeremy, Rolland, Norbert, Wilhelm, Ralf, Davies, Jessica, Inzé, Dirk, Parry, Martin A. J., and Klein Lankhorst, René

Subjects
GREENHOUSE gases, PLANT breeding, AGRICULTURAL productivity, CROPS, CLIMATE change
Abstract

The world needs more than double its current agricultural productivity by 2050 to produce enough food and feed, as well as to provide feedstock for the bioeconomy. These future increases will not only need to be sustainable but without comprommising the nutritional quality, and ideally also need to decrease greenhouse gas emissions and increase carbon sequestration to help mitigate the consequences of global climate change. These challenges could be tackled by developing and integrating new future‐proof crops into our food system. The H2020 CropBooster‐P project sets out plant‐centered breeding approaches guided by a broad socio‐economic and societal support. First, the potential approaches for breeding crops with sustainably increased yields adapted to the future climate of Europe are identified. These crop‐breeding options are subsequently prioritized and their adoption considered by experts across the agri‐food system and the wider public, taking into account environmental, economic and other technical criteria. In this way, a specific research agenda to future‐proof our crops was developed, supported by an eventual implementation plan. [ABSTRACT FROM AUTHOR]

Published
2023
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49. European consumer and societal stakeholders' response to crop improvements and new plant breeding techniques.

Author

Nair, Abhishek, Fischer, Arnout R. H., Moscatelli, Silvana, Socaciu, Carmen, Kohl, Christian, Stetkiewicz, Stacia S., Menary, Jonathan, Baekelandt, Alexandra, Nanda, Amrit K., Jorasch, Petra, Davies, Jessica A. C., and Wilhelm, Ralf

Subjects
PLANT breeding, CROP improvement, CULTIVARS, CROP yields, CONSUMERS
Abstract

The global demand for providing nutritious, sustainable, and safe diets for a 10 billion population by 2050 while preserving affordability, reducing environmental impacts, and adapting to climate change will require accelerating the transition to sustainable agri‐food systems. A plausible way to help tackle these challenges is by developing new plant varieties that have improved crop yield, plant nutritional quality, and sustainability (or resilience) traits. However, stakeholders, consumers, and citizens' concerns and appreciation of future‐proofing crops and the acceptability of new plant breeding strategies are not well‐established. These groups are actors in the agri‐food systems, and their views, values, needs, and expectations are crucial in helping to co‐design fair, ethical, acceptable, sustainable, and socially desirable policies on new plant breeding techniques (NPBTs) and the transition to sustainable agri‐food systems. In this study, we engaged with consumer experts and societal stakeholders to consider their perceptions, expectations, and acceptability of improving crops and NPBTs for future‐proofing the agri‐food systems. Our analysis points to a need for governments to take a proactive role in regulating NPBTs, ensure openness and transparency in breeding new crop varieties, and inform consumers about the effects of these breeding programmes and the risks and benefits of the new crop varieties developed. Consumer experts and societal stakeholders considered these strategies necessary to instil confidence in society about NPBTs and accelerate the transition to sustainable agri‐food systems. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Crop improvements for future‐proofing European food systems: A focus‐group‐driven analysis of agricultural production stakeholder priorities and viewpoints.

Author

Stetkiewicz, Stacia, Menary, Jonathan, Nair, Abhishek, Rufino, Mariana C., Fischer, Arnout R.H., Cornelissen, Marc, Duchesne, Remi, Guichaoua, Adrien, Jorasch, Petra, Lemarié, Stephane, Nanda, Amrit K., Wilhelm, Ralf, and Davies, Jessica A.C.

Subjects
AGRICULTURAL productivity, CROP improvement, PLANT breeding, FOOD crops, COMMUNITIES
Abstract

Crop breeding is one of the main tools which can assist in future‐proofing food systems for more sustainable outcomes. In order to ensure priorities are aligned with the needs and wants of food system actors, it is essential to engage with key stakeholders to understand preferences on plant breeding solutions. This study presents results from a series of online focus groups conducted with agricultural production related stakeholders (i.e. farmers and farmer representatives, policymakers and NGOs) regarding the potential for crop improvement to future‐proof European food systems. Stakeholders shared concern around climate change and environmental impacts (particularly drought and heat stress), and general agreement about the need to develop resilient crops which combine multiple positive attributes, while reducing trade‐offs and negative externalities. Stakeholders also prioritized plant breeding solutions for areas where they felt they had little agency, and existing alternative solutions, such as improving input use efficiency, or altering diets to be considered where these are available. This highlights the need for the crop breeding community to focus its attentions on the 'most hard to fix' issues, where in‐field measures are currently not offering viable solutions, to maximize acceptance and adoption by agricultural production stakeholders. It also highlights that consideration of trade‐offs, within plant and within a broader agri‐food context, must be integrated into crop breeding research and development, with trade‐off analysis an explicit component of breeding research. Understanding broader agri‐food system knock‐on effects of plant innovation is a non‐trivial challenge requiring interdisciplinary research and close partnerships with food system stakeholders. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
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