10 results on '"De-Chun Jiang"'
Search Results
2. Genomic adaptations for arboreal locomotion in Asian flying treefrogs
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Wei Wu, Yue-Dong Gao, De-Chun Jiang, Juan Lei, Jin-Long Ren, Wen-Bo Liao, Cao Deng, Zeng Wang, David M. Hillis, Ya-Ping Zhang, and Jia-Tang Li
- Subjects
Multidisciplinary ,Animals ,Humans ,Genomics ,Anura ,Adaptation, Physiological ,Biological Evolution ,Locomotion ,Biomechanical Phenomena ,Trees - Abstract
Significance To adapt to arboreal lifestyles, treefrogs have evolved a suite of complex traits that support vertical movement and gliding, thus presenting a unique case for studying the genetic basis for traits causally linked to vertical niche expansion. Here, based on two de novo-assembled Asian treefrog genomes, we determined that genes involved in limb development and keratin cytoskeleton likely played a role in the evolution of their climbing systems. Behavioral and morphological evaluation and time-ordered gene coexpression network analysis revealed the developmental patterns and regulatory pathways of the webbed feet used for gliding in Rhacophorus kio .
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- 2022
3. High-Dose Tigecycline in Elderly Patients with Pneumonia Due to Multidrug-Resistant Acinetobacter baumannii in Intensive Care Unit
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Xiang-Rong Bai, De-Chun Jiang, and Su-Ying Yan
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0301 basic medicine ,medicine.medical_specialty ,medicine.drug_class ,030106 microbiology ,Antibiotics ,Drug resistance ,Tigecycline ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Pharmacology ,biology ,business.industry ,Hazard ratio ,Retrospective cohort study ,biology.organism_classification ,medicine.disease ,Intensive care unit ,Acinetobacter baumannii ,Pneumonia ,Infectious Diseases ,business ,medicine.drug - Abstract
Purpose The association between clinical and microbiological outcomes and high-dose tigecycline (TGC) was assessed in elderly (≥60 years old) patients with hospital-acquired and ventilator-associated pneumonia due to multidrug-resistant Acinetobacter baumannii(A. baumannii). This study also assessed tigecycline combination with different antibiotics and its influence on the outcome. Patients and methods An observational retrospective cohort study was conducted. Patients over 60 years old were treated with standard-dose (SD) TGC (100-mg intravenous TGC initially, followed by 50-mg doses administered intravenously twice daily) and high-dose (HD) TGC (200-mg intravenous TGC initially, followed by 100-mg doses administered intravenously twice daily) for a microbially confirmed infection. The outcome was 30-day crude mortality, co-administered antimicrobial agent and the microbial eradication percentage in both groups. Results A total of 48 multidrug-resistant A. baumannii respiratory patients were identified. Tigecycline was administered to 85% of ventilation-associated pneumonia (VAP) patients (28/33) in the SD group and 80% of VAP patients (12/15) in the HD group. Combined therapy was the major treatment option in both groups, accounting for 85% and 87%, respectively. Median treatment duration in both groups was 7.36 vs 8.6 days, respectively. Survival days were 13.61 vs 12.4 days (P=0.357), respectively. The 30-day crude mortality was 39.4% (13/33) for the SD group and 14% (2/15) for the HD group (P=0.098). The microbial eradication rate of respiratory specimens in the SD group was higher than that in the HD group (P=0.02). The variables associated with 30-day crude mortality were chronic obstructive pulmonary disease (hazard ratio [HR] 11.63, 95% CI 1.094-123.058; P=0.042), tigecycline treatment duration (HR 0.690, 95% CI 0.515-0.926; P=0.013), and surgery before infection (HR 79.276, 95% CI 6.983-899.979; P=0.000). High-dose tigecycline was not associated with 30-day crude mortality (adjusted HR 0.329, 95% CI 0.074-1.460; P=0.145). Combined antibiotics was also not different between the two groups. Conclusions High-dose tigecycline was not associated with 30-day crude mortality in elderly patients with pneumonia due to multidrug-resistant A. baumannii, although the microbial eradication rate was high.
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- 2020
4. Next-generation sequencing yields the complete mitochondrial genome of the Shangrila hot-spring snakes (
- Author
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Wei, Wu, De-Chun, Jiang, and Feng-Hui, Sun
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Mitogenome ,next-generation sequencing ,Thermophis shangrila ,Mitogenome Announcement ,Research Article - Abstract
In this study, we sequenced the complete mitochondrial genome of Thermophis shangrila by using the next-generation sequencing technique. The total length of the mitogenome was 17,407 bp, which was composed of 13 protein coding genes, two rRNA genes (12s and 16s rRNA), 22 tRNA genes, and two control regions (CRI and CRII). The base composition was 32.6% for A, 23.9% for T, 30.0% for C, and 13.5% for G. We added a fragment about 150 bp in length at control region I, which Peng et al. failed to obtain using Sanger dideoxy sequencing.
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- 2021
5. Geographical range evolution of the genus
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Li-Mei, Yuan, Xi-Ling, Deng, De-Chun, Jiang, Sebastian, Klaus, Nikolai L, Orlov, Kong, Yang, and Jia-Tang, Li
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Biogeography ,Paleoclimate ,parasitic diseases ,Animals ,Anura ,Letters to the Editor ,Animal Distribution ,Biological Evolution ,Southeast Asia ,Polypedates ,Phylogeny - Abstract
Currently, the genus Polypedates comprises 26 species distributed in South, Southeast, and East Asia. Because of their relatively low dispersal capability and intolerance to seawater, this genus is ideal for the study of terrestrial range evolution that extends into the island archipelagos of southeastern Asia. In this study, based on data compiled for Polypedatesfrom previous studies and partial mitochondrial and nuclear genes collected in this study, we performed systematic biogeographical analysis. We confirmed a Sundaland origin for the extant genus and showed northward dispersal into mainland Southeast Asia and Asia, which coincided with the timing of paleoclimatic change from the Oligocene to Middle Miocene. Climate fluctuations had a profound impact on species diversification within the genus Polypedates. Furthermore, the Red River did not mediate species exchange between Southeast Asia and mainland Asia until the end of the Miocene, with the sudden onset of northward dispersal in several clades independently at that time. Alternatively, the lineage of widespread insular P. leucomystaxstrongly supports the hypothesis of terrestrial connection between island archipelagos of Southeast Asia during the Mid-Pleistocene paleoclimate fluctuations. Our biogeographical analysis also supports the recent introduction of P. leucomystax to the Philippines and Ryukyus, as previously suggested.
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- 2020
6. Geographical range evolution of the genus Polypedates (Anura: Rhacophoridae) from the Oligocene to present
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Li-Mei Yuan, Xi-Ling Deng, De-Chun Jiang, Sebastian Klaus, Nikolai L. Orlov, Kong Yang, and Jia-Tang Li
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polypedates ,ddc:590 ,southeast asia ,paleoclimate ,lcsh:Zoology ,parasitic diseases ,lcsh:QL1-991 ,phylogeny ,biogeography - Abstract
Currently, the genus Polypedates comprises 26 species distributed in South, Southeast, and East Asia. Because of their relatively low dispersal capability and intolerance to seawater, this genus is ideal for the study of terrestrial range evolution that extends into the island archipelagos of southeastern Asia. In this study, based on data compiled for Polypedates from previous studies and partial mitochondrial and nuclear genes collected in this study, we performed systematic biogeographical analysis. We confirmed a Sundaland origin for the extant genus and showed northward dispersal into mainland Southeast Asia and Asia, which coincided with the timing of paleoclimatic change from the Oligocene to Middle Miocene. Climate fluctuations had a profound impact on species diversification within the genus Polypedates. Furthermore, the Red River did not mediate species exchange between Southeast Asia and mainland Asia until the end of the Miocene, with the sudden onset of northward dispersal in several clades independently at that time. Alternatively, the lineage of widespread insular P. leucomystax strongly supports the hypothesis of terrestrial connection between island archipelagos of Southeast Asia during the Mid-Pleistocene paleoclimate fluctuations. Our biogeographical analysis also supports the recent introduction of P. leucomystax to the Philippines and Ryukyus, as previously suggested.
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- 2020
7. Incidence, mortality and risk factors of drug-induced acute kidney injury: A multi-center study in China
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Xiaohui Cui, Yangxin Zhang, Li Yang, Chen Liu, Suying Yan, De-Chun Jiang, Qiang Jia, and Yuqin Wang
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Drug ,medicine.medical_specialty ,business.industry ,Applied Mathematics ,General Mathematics ,Incidence (epidemiology) ,media_common.quotation_subject ,Acute kidney injury ,medicine.disease ,Multi center study ,Internal medicine ,Medicine ,business ,media_common - Published
- 2018
8. Geographical range evolution of the genus Polypedates (Anura: Rhacophoridae) from the Oligocene to present.
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Li-Mei Yuan, Xi-Ling Deng, De-Chun Jiang, Klaus, Sebastian, Orlov, Nikolai L., Kong Yang, and Jia-Tang Li
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WHITE-lipped treefrog ,BIOGEOGRAPHY ,CLIMATE change ,SPECIES diversity ,BIOLOGICAL evolution - Abstract
The article discusses a study which performed systematic biogeographical analysis of the genus Polypedates. Topics covered include the impact of climate fluctuations on species diversification within the genus Polypedates, its geographical range evolution from the Oligocene to present, and the recent introduction of Polypedates leucomystax to the Philippines and the Ryukyu Islands, Japan.
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- 2021
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9. Population pharmacokinetics of valproate in Chinese children with epilepsy
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Lin Li, Wei Lu, De-Chun Jiang, Li Wang, Yu-Qin Wang, and Xiang-Rong Bai
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Male ,China ,medicine.medical_specialty ,Adolescent ,Mean squared prediction error ,Population ,Population pharmacokinetics ,Pharmacology ,Models, Biological ,Gastroenterology ,Epilepsy ,Pharmacokinetics ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Child ,education ,education.field_of_study ,business.industry ,Valproic Acid ,Infant ,Bayes Theorem ,General Medicine ,Serum concentration ,medicine.disease ,Confidence interval ,NONMEM ,Child, Preschool ,Anticonvulsants ,Female ,business - Abstract
Aim: The aim of the present study is to establish a population pharmacokinetic (PPK) model of valproate (VPA) in Chinese epileptic children to promote the reasonable use of anti-epileptic drugs. Methods: Sparse data of VPA serum concentrations from 417 epileptic children were collected. These patients were divided into 2 groups: the PPK model group ( n =317) and the PPK valid group ( n =100). The PPK parameter values of VPA were calculated by NONMEM software using the data of the PPK model group. A basic model and a final model were set up. To validate the 2 models, the concentrations of PPK valid group were predicted by each model, respectively. The mean prediction error (MPE), mean squared prediction error (MSPE), root mean squared prediction error (RMSPE), weight residues (WRES), and the 95% confidence intervals (95% CI) were also calculated. Then, the values between the 2 models were compared. Results: The PPK of VPA was determined by a 1-compartment model with a first-order absorption process. The basic model was: Ka=3.09 (h -1 ), V/F=20.4 (L), CL/F=0.296 (L/h). The final model was: Ka=0.251+2.24dot(1-HS) (h -1 ), V/F=2.88+0.157dotWT (L), CL/F=0.106 0.98dotCO + 0.0157dotAGE (L/h). For the basic model, the MPE, MSPE, RMSPE, WRES, and the 95% CI were -23.53 (-30.36, -16.70), 3728.96 (2872.72, 4585.20), 39.62 (34.34, 44.90), and -0.06 (-0.14, 0.02), respectively. For the final model, the MPE, MSPE, RMSPE, WRES, and the 95% CI were -1.16 (-4.85, 2.53), 1002.83 (1050.64, 1143.61), 23.04 (21.12, 24.96), and 0.08 (-0.04, 0.20), respectively. The final model was more optimal than the basic model. Conclusion: The PPK model of VPA in Chinese epileptic children was successfully established. It will be valuable to facilitate individualized dosage regimens.
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- 2007
10. Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy
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De-chun, Jiang and Li, Wang
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Male ,Random Allocation ,Epilepsy ,Adolescent ,Child, Preschool ,Valproic Acid ,Humans ,Infant ,Bayes Theorem ,Female ,Models, Theoretical ,Child - Abstract
Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach.Two hundred epileptic children, whose VPA serum concentrations were collected, were divided randomly into two groups (A and B, n=100 each). The PPK parameter values of group A were calculated to establish a PPK Model by using the NPEM Program of USC*PACK software. Based on it, VPA serum concentrations of group B were predicted with the Bayesian Fitting Program of the USC*PACK software. To assess the accuracy and precision of prediction, a paired-comparisons t-test was run between predicted and observed concentrations, and then the mean prediction error (MPE), mean square prediction error (MSPE), root mean square prediction error (RMSPE), and coincidence rates for different percentages of prediction error were all calculated.Optimum PPK parameters were: Ka, 2.522+/-2.743 h(-1); Vs, 0.329+/-0.496 L/kg; and Kel, 0.0438+/-0.0384 h(-1). For group B, there was no significant difference between predicted and observed concentrations. MPE was -0.43 mg/L, MSPE was 115.40 (mg/L)2, and RMSPE was 5.47 mg/L. The coincidence rates for percentages of prediction error, which were less than 5 %, 10 %, 15 %, 20 %, 25 %, and 30 %, were 62 %, 74 %, 82 %, 85 %, 89 %, and 93 %, respectively.A PPK model of VPA in epileptic children was successfully established. Based on it, VPA serum concentrations can be predicted accurately with a Bayesian approach.
- Published
- 2004
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