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14 results on '"Detrisac, Carol J."'

6. West Nile Virus encephalomyelitis in horses: 46 cases (2001)

Author

Porter, Michael B., primary, Long, Maureen T., additional, Getman, Liberty M., additional, Giguère, Steeve, additional, MacKay, Robert J., additional, Lester, Guy D., additional, Alleman, A. Richard, additional, Wamsley, Heather L., additional, Franklin, Robert P., additional, Jacks, Stephanie, additional, Buergelt, Claus D., additional, and Detrisac, Carol J., additional

Published
2003
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10. Clinicopathologic Findings Associated with Lagenidiumsp. Infection in 6 Dogs: Initial Description of an Emerging Oomycosis

Author

Grooters, Amy M., Hodgin, E. Clay, Bauer, Rudy W., Detrisac, Carol J., Znajda, Nadine R., and Thomas, Randall C.

Abstract

An oomycotic pathogen in the genus Lagenidiumwas isolated from tissues obtained from 6 dogs with progressive cutaneous disease. Initial clinical findings in 5 dogs included multifocal cutaneous lesions, subcutaneous lesions, or both associated with regional lymphadenopathy; the 6th dog initially was presented for evaluation of mandibular lymphadenopathy. Cutaneous lesions were ulcerated, exudative regions (often with necrosis and draining tracts) or multiple firm dermal or subcutaneous nodules. Two dogs subsequently developed hemoabdomen from great vessel rupture and died acutely. Four dogs were euthanized because of progression of subcutaneous lesions or lymphadenopathy. On postmortem examination, regional granulomatous lymphadenitis was found in all 6 dogs, great vessel invasion in 3 dogs, pulmonary lesions in 2 dogs, ureteral obstruction in 1 dog, mediastinal lymphadenitis in 1 dog, and hilar lymphadenitis with invasion of the distal esophagus and trachea in 1 dog. Histologically, lesions were similar to those associated with pythiosis and zygomycosis and were characterized by severe eosinophilic granulomatous inflammation (often with numerous large multinucleated giant cells) centered around broad (7–25 /L), infrequently septate hyphae. Immunoblot analysis of the serologic response of 4 dogs to a soluble mycelial extract of Lagenidium giganteumindicated that each dog's serum recognized at least 10 different antigens of L giganteum.Culture of infected tissues yielded rapid growth of colorless to white submerged colonies. Microscopically, mature hyphae in culture were broad (25–40 /L),segmented, and occasionally branching and produced motile laterally biflagellate zoospores in water culture. This report is the 1st description of infection caused by an oomycete other than Pythium insidiosumin any mammalian species.

Published
2003
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14. Evaluation of oxidative stress markers for the early diagnosis of allograft rejection in feline renal allotransplant recipients with normal renal function.

Author

Halling KB, Ellison GW, Armstrong D, Aoyagi K, Detrisac CJ, Graham JP, Newell SP, Martin FG, and Van Gilder JM

Subjects
Animals, Biomarkers blood, Cat Diseases surgery, Cats, Creatinine urine, Fever veterinary, Graft Rejection blood, Graft Rejection diagnosis, Kidney blood supply, Kidney diagnostic imaging, Kidney Failure, Chronic surgery, Kidney Failure, Chronic veterinary, Kidney Function Tests methods, Kidney Function Tests veterinary, Lactic Acid blood, Male, Oxidative Stress, Predictive Value of Tests, Specific Pathogen-Free Organisms, Ultrasonography, Creatinine analogs & derivatives, Creatinine blood, Graft Rejection veterinary, Kidney Transplantation veterinary, Thiobarbituric Acid Reactive Substances
Abstract

The purpose of this study was to identify oxidative damage to renal allografts during graft rejection by evaluating changes in oxidative markers and plasma lactate levels in feline renal allotransplant recipients. Heterotopic renal allotransplantations were performed between 8 adult feline cross-matched donors. Following 14 d of immunosuppression, the drugs were discontinued to allow allograft rejection. Baseline and serial postoperative evaluations of serum creatinine, plasma lactate, plasma thiobarbituate reactive substances (TBARS), plasma creatol, urine creatol, and renal sonographic cross-sectional area were performed. When sonographic evaluation revealed the absence of blood flow to the allograft, the rejected kidney was nephrectomized and evaluated histopathologically. Allograft rejection occurred in all cats by day 26. A significant elevation in body temperature occurred during the rejection period. No significant change was observed between any of the time periods for plasma TBARS, creatol, or urine creatol. There was a significant decrease in plasma lactate levels throughout the study. Markers of oxidative stress from venous blood did not reflect renal allograft rejection in cats with a normally functioning native kidney. Renal allograft rejection may be associated with significant increases in body temperature and warrants further investigation.

Published
2004

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