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Mengshi Zhong,1 Fei She,2 Weijie Wang,1 Lianshu Ding,1 Aifeng Wang1 1Department of Neurosurgery, Huai’an First Hospital Affiliated to Nanjing Medical University, Huai’an, 223300, People’s Republic of China; 2Department of Nursing Administration, Huai’an First Hospital Affiliated to Nanjing Medical University, Huai’an, 223300, People’s Republic of ChinaCorrespondence: Lianshu Ding; Aifeng Wang, Department of Neurosurgery, Huai’an First Hospital Affiliated to Nanjing Medical University, Huai’an, 223300, People’s Republic of China, Email dlshu@163.com; 13770483620@163.comObjective: To investigate the mediating effect of resilience on perceived social support and fear of cancer recurrence (FCR) in glioma patients.Methods: A total of 128 glioma patients were enrolled for the survey by Connor-Davidson resilience scale (CD-RISC), perceived social support scale (PSSS) and Chinese version of fear of progression questionnaire-short form (FoP-Q-SF). Structural equation model was used to analyze the effects of resilience.Results: The score of FCR in glioma patients was 29.52± 8.30. A total of 47 patients had FCR (total score ≥ 34), with an incidence of 36.7%. There was a correlation between FCR, resilience and social support (P< 0.01). The resilience between perceived social support and FCR in glioma patients had good fitting with the structural equation model. Resilience played a mediating role between perceived social support and FCR, with a mediating effect of 48.4%.Conclusion: The level of resilience can be improved by improving the perceived social support in patients with glioma to reduce the FCR of patients.Keywords: glioma, fear of cancer recurrence, resilience, perceived social support, mediating effect

The abnormal metabolic processes following traumatic brain injury (TBI) have been proposed to contribute to secondary injuries after TBI. Therefore, enteral nutrition (EN) support for TBI patients has received more attention. This study aimed to evaluate the complimentary effects of enteral nutrition with glutamine and hyperbaric oxygen (HBO) on the recovery of TBI. TBI model was established in SD rats, which were randomly divided into four groups: TBI, TBI + HBO, TBI + GLN, and TBI + HBO + GLN. Neuronal apoptosis in penumbra area was detected by TUNEL. Serum prealbumin level was detected by ELISA. Motor function was evaluated by beam-balance test. We found that the body weight of the rats had no significant differences in different groups before and after injury. Among the four groups, beam-balance test score was the lowest, serum prealbumin level was the highest, and neuronal apoptosis rate was the lowest in TBI + HBO + GLN group on day 3 and 7 after TBI. In conclusion, our data suggest that hyperbaric oxygen combined with enteral nutrition support with glutamine is effective in reducing neuronal apoptosis, increasing serum prealbumin concentration and improving neurological function after TBI injury.